Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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In vitro study on the impact of fish sera on the survival and fine structure of the eel-pathogenic acanthocephalan Paratenuisentis ambiguus. | The effects of fish sera on the growth and fine structure of infective larvae of the eel-pathogenic acanthocephalan Paratenuisentis ambiguus (Eoacanthocephala: Tenuisentidae) were studied under in vitro conditions using sera from the final host Anguilla anguilla and from two accidental fish hosts as well as fetal calf ... | ['Acanthocephala', 'Anguilla', 'Animals', 'Carps', 'Culture Media', 'Female', 'Fish Diseases', 'Helminthiasis', 'Helminthiasis, Animal', 'Immune Sera', 'Male', 'Microscopy, Electron', 'Species Specificity', 'Trout'] | 1,805,215 | [['B01.050.500.500.132'], ['B01.050.150.900.493.338.282'], ['B01.050'], ['B01.050.150.900.493.200.244.248'], ['D27.720.470.305', 'E07.206'], ['C22.362'], ['C01.610.335'], ['C01.610.335.349', 'C01.610.701.377', 'C22.674.377'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D12.776... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gastrulation and mesoderm morphogenesis in the white sturgeon. | This study presents a detailed description of gastrulation in the white sturgeon, Acipenser transmontanus, using scanning electron microscopy, histology, and time-lapse filming and video microscopy. This morphological analysis describes the similarity of gastrula structure in the sturgeon and the amphibian Xenopus laev... | ['Animals', 'Cell Movement', 'Female', 'Fishes', 'Gastrula', 'In Vitro Techniques', 'Male', 'Mesoderm', 'Microscopy, Electron, Scanning', 'Morphogenesis', 'Photomicrography', 'Videotape Recording', 'Xenopus laevis'] | 8,501,436 | [['B01.050'], ['G04.198', 'G07.568.500.180'], ['B01.050.150.900.493'], ['A16.441'], ['E05.481'], ['A16.504.660'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['G07.345.500'], ['E01.370.350.515.799', 'E01.370.350.600.635', 'E05.595.799'], ['J01.897.280.500.846.734', 'J01.897.280.500.898.840', 'L01.178.590.875.840', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Role of parasite transmission in promoting inbreeding: II. Pedigree reconstruction reveals sib-transmission and consequent kin-mating. | Even though parasitic flatworms are one of the most species-rich groups of hermaphroditic organisms, we know virtually nothing of their mating systems (selfing or kin-mating rates) in nature. Hence, we lack an understanding of the role of inbreeding in parasite evolution. The natural mating systems of parasitic flatwor... | ['Animals', 'Biological Evolution', 'Cestoda', 'Genetic Variation', 'Genetics, Population', 'Hermaphroditic Organisms', 'Inbreeding', 'Inbreeding Depression', 'Linkage Disequilibrium', 'Lizards', 'Microsatellite Repeats', 'Parasites', 'Pedigree', 'Reproduction'] | 28,626,973 | [['B01.050'], ['G05.045', 'G16.075'], ['B01.050.500.500.736.215'], ['G05.365'], ['H01.158.273.343.335'], ['B05.275'], ['E05.820.150.520', 'G05.090.403'], ['G05.410'], ['G05.348.500'], ['B01.050.150.900.833.393'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['B01.050.500.714'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Primary structure of rabbit skeletal muscle glycogen synthase deduced from cDNA clones. | The complete amino acid sequence of rabbit skeletal muscle glycogen synthase was deduced from cDNA clones with a composite length of 3317 bp. An mRNA of 3.6 kb was identified by Northern blot analysis of rabbit skeletal muscle RNA. The mRNA coded for a protein of 734 residues with a molecular weight of 83,480. The dedu... | ['Amino Acid Sequence', 'Animals', 'Base Composition', 'Base Sequence', 'Codon', 'DNA', 'Glycogen Synthase', 'Humans', 'Isoelectric Point', 'Molecular Sequence Data', 'Muscles', 'Nucleic Acid Hybridization', 'Rabbits', 'Sequence Homology, Nucleic Acid'] | 2,509,275 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.080'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['D13.444.308'], ['D08.811.913.400.450.460.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.301.30... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Pharmacological studies of stonefish (Synanceja trachynis) venom. | The present study was designed to examine some of the pharmacological properties of venom from the stonefish (Synanceja trachynis), with particular reference to the presence in the venom of pain-producing/enhancing substances. Stonefish venom (1-6 micrograms/ml) produced concentration-dependent contractile responses in... | ['Animals', 'Biphenyl Compounds', 'Blood Pressure', 'Captopril', 'Chromones', 'Dose-Response Relationship, Drug', 'Fish Venoms', 'Fishes', 'Guinea Pigs', 'Heptanoic Acids', 'Histamine', 'Ileum', 'Imidazoles', 'In Vitro Techniques', 'Indomethacin', 'Losartan', 'Male', 'Mecamylamine', 'Muscle Contraction', 'Muscle, Smoot... | 7,846,690 | [['B01.050'], ['D02.455.426.559.389.185'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D12.125.072.401.623.270'], ['D03.383.663.283.266', 'D03.633.100.150.266'], ['G07.690.773.875', 'G07.690.936.500'], ['D20.888.370', 'D23.946.580.370', 'D23.946.833.370'], ['B01.050.150.900.493'], ['B01.050.150.900.649.313.992.550'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Clinical analysis of transumbilical single-incision laparoscopic cholecystectomy with totally free umbilical ring by conventional instruments]. | Objective: To summarize the clinical experience of transumbilical single-port laparoscopic cholecystectomy, and evaluate its clinical utility and the feasibility of widely usage. Methods: Between April 2012 and June 2017, 500 cases who underwent transumbilical single-port laparoscopic cholecystectomy with totally free ... | ['Cholecystectomy, Laparoscopic', 'Gallbladder Diseases', 'Humans', 'Retrospective Studies', 'Treatment Outcome', 'Umbilicus'] | 30,669,800 | [['E04.210.120.172.140', 'E04.502.250.520.160'], ['C06.130.564'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E01.789.800', 'N04.761.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
High temperature environment reduces olive oil yield and quality. | Global warming is predicted to have a negative effect on plant growth due to the damaging effect of high temperatures. In order to address the effect of high temperature environments on olive oil yield and quality, we compared its effect on the fruit development of five olive cultivars placed in a region noted for its ... | ['Climate', 'Food Quality', 'Fruit', 'Genotype', 'Olea', 'Olive Oil', 'Temperature'] | 32,324,774 | [['G16.500.275.071', 'N06.230.300.100.250'], ['J01.576.423.850.730', 'N06.850.601'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['G05.380'], ['B01.650.940.800.575.912.250.583.640.666'], ['D10.212.302.380.580', 'D10.212.507.650', 'D10.627.700.728', 'G07.203.300.375.400.500', 'J02.500.375.400.500'], ['G01.906.595... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
The blood supply of early, late, and nonossifying cartilage: preliminary gray-scale and Doppler assessment and their implications. | BACKGROUND: Comparative gray-scale Doppler US studies of various cartilages have not been reported before.OBJECTIVE: To study gray-scale US and perfusion patterns of different cartilages.MATERIALS AND METHODS: Three groups of cartilages were studied in 42 normal neonates. Group A included the proximal femoral chondroep... | ['Adult', 'Cartilage', 'Epiphyses', 'Female', 'Femur Head', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Patella', 'Prospective Studies', 'Ribs', 'Tibia', 'Ultrasonography, Doppler'] | 18,040,678 | [['M01.060.116'], ['A02.165', 'A10.165.382'], ['A02.835.232.251'], ['A02.835.232.043.150.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['A02.835.232.043.650.624', 'A02.835.232.730.500'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.6... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Phase imaging of axonal integrity of cranial corticospinal tract in experimental spinal cord injury at 9.4T. | It was known that Spinal cord injury (SCI) leads to neuronal cell death, axonal damage and demyelination, and often results in severe functional loss. Noninvasive imaging of axonal integrity may hold great importance in clinic. This study evaluated the role of phase imaging in detection of axonal integrity of cranial c... | ['Animals', 'Axons', 'Brain', 'Diffusion Tensor Imaging', 'Pyramidal Tracts', 'Rats', 'Rats, Sprague-Dawley', 'Spinal Cord', 'Spinal Cord Injuries'] | 28,544,025 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.186.211'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['A08.186.854.300', 'A08.612.380.730'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.50... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of organic solvent mixtures on biological membranes. | A simple experimental model was used to study the influence of organic solvents and solvent mixtures on the integrity of biological membranes. Radiolabelled membranes were prepared biosynthetically by growing Escherichia coli in the presence of 14C-oleic acid; the bulk of the radioactivity was incorporated into 14C-pho... | ['Acetone', 'Alcohols', 'Animals', 'Butanones', 'Cell Membrane', 'Dimethylformamide', 'Drug Synergism', 'Escherichia coli', 'Ethanol', 'Ethylene Glycol', 'Ethylene Glycols', 'Solvents'] | 3,899,160 | [['D02.522.064'], ['D02.033'], ['B01.050'], ['D02.522.296'], ['A11.284.149'], ['D02.065.463.387', 'D02.241.081.420.500.387'], ['G07.690.773.968.477'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D02.033.375'], ['D02.033.455.250.268'], ['D02.033.455.250'], ['D27.720.844']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Changes and clinical significance of CD8(+) T cell subset in patients with aplastic anemia, myelodysplastic syndrome and acute myeloid leukemia]. | This study was purposed to detect the balance and the activity change of cytotoxic T cell subsets in aplastic anemia (AA) patients, myelodysplastic syndrome (MDS) patients and acute myeloid leukemia (AML) patients, and to explore the cellular immune mechanism for abnormal hematopoiesis of the three diseases, so as to p... | ['Adolescent', 'Adult', 'Aged', 'Anemia, Aplastic', 'CD8-Positive T-Lymphocytes', 'Case-Control Studies', 'Female', 'Flow Cytometry', 'Humans', 'Leukemia, Myeloid, Acute', 'Lymphocyte Count', 'Male', 'Middle Aged', 'Myelodysplastic Syndromes', 'Young Adult'] | 23,484,720 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C15.378.071.085', 'C15.378.190.223.250'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.225.500.363.342', 'E01.370.225.5... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The chromatin-remodelling factor PICKLE interacts with CONSTANS to promote flowering in Arabidopsis. | In many flowering plants, successful reproductive development depends on the plant's ability to sense seasonal photoperiodic changes and adjust its vegetative growth accordingly. In Arabidopsis thaliana, the day-length-dependent accumulation of CONSTANS (CO) is crucial for the rhythmic activation of FLOWERING LOCUS T (... | ['Arabidopsis', 'Arabidopsis Proteins', 'Chromatin Assembly and Disassembly', 'DNA Helicases', 'DNA-Binding Proteins', 'Flowers', 'Gene Expression Regulation, Plant', 'Transcription Factors'] | 30,965,386 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['G04.400.095', 'G05.213.095', 'G05.308.095'], ['D08.811.277.040.025.159', 'D08.811.399.340'], ['D12.776.260'], ['A18.024.249.500'], ['G05.308.375'], ['D12.776.930']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acanthocephalan Cystacanths from Flatfish (Order Pleuronectiformes) in Tropical Australian Waters. | Cystacanths of 4 species of Acanthocephala are reported for the first time from various species of fish belonging to the Order Pleuronectiformes from waters of the western Gulf of Carpentaria and the central coast of Queensland, Australia: Corynosoma cetaceum Johnston and Best, 1942 (Family Polymorphidae), Serrasentis ... | ['Acanthocephala', 'Animals', 'Female', 'Fish Diseases', 'Flatfishes', 'Helminthiasis, Animal', 'Male', 'Queensland', 'Seawater', 'Tropical Climate'] | 25,807,200 | [['B01.050.500.500.132'], ['B01.050'], ['C22.362'], ['B01.050.150.900.493.418'], ['C01.610.335.349', 'C01.610.701.377', 'C22.674.377'], ['Z01.639.100.937', 'Z01.678.100.373.937'], ['G16.500.275.725.500'], ['G16.500.275.071.600', 'N06.230.300.100.250.600']] | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Trichostrongylina (Nematoda) from Malagasy muridae. II--Description of two new species of Heligmonina (Heligmonellidae) in Nesomys rufus and Eliurus tanala. | Two new species of Heligmonellidae from Madagascar are described, Heligmonina madagascariensis n. sp. in Nesomys rufus and Heligmonina tanala n. sp. in Eliurus tanala. Both species belong to the Heligmonina species with a pattern of type 1-3-1 for the right lobe of the caudal bursa and 1-4 for the left lobe. In H. mada... | ['Animals', 'Female', 'Madagascar', 'Male', 'Muridae', 'Rodent Diseases', 'Species Specificity', 'Trichostrongyloidea', 'Trichostrongyloidiasis'] | 12,116,858 | [['B01.050'], ['Z01.639.520.500'], ['B01.050.150.900.649.313.992.635'], ['C22.795'], ['G16.824'], ['B01.050.500.500.294.400.968.746'], ['C01.610.335.508.700.775.825']] | ['Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Recombinant interleukin-2-activated intracavitary lymphocytes: phenotypic characteristics and effector function. | A preclinical study of intracavitary lymphocytes (ICL) from malignant effusions of cancer patients is described. The object of this study was to evaluate the antitumor potential of ICL as a baseline for developing adoptive immunotherapy trial for ovarian carcinoma patients. The main parameters studied were functional c... | ['Antigens, Surface', 'Antineoplastic Agents', 'Cells, Cultured', 'Cytotoxicity, Immunologic', 'Exudates and Transudates', 'Female', 'Humans', 'Interleukin-2', 'Kinetics', 'Lymphocyte Activation', 'Lymphocytes', 'Phenotype', 'Recombinant Proteins'] | 2,787,838 | [['D23.050.301'], ['D27.505.954.248'], ['A11.251'], ['G12.287'], ['A12.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.480.372', 'D23.529.374.465.155', 'D23.529.374.480.372'], ['G01.374.661', 'G02.111.490'], ['E01... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Localization of the human dihydropteridine reductase gene to band p15.3 of chromosome 4 by in situ hybridization. | We report the localization of the gene for dihydropteridine reductase (DHPR) to the human chromosome region 4p15.3 by in situ hybridization using a cDNA probe to the enzyme. The distal end of the short arm of chromosome 4 is of considerable interest because the gene responsible for Huntington's disease is located in th... | ['Base Sequence', 'Chromosome Banding', 'Chromosome Mapping', 'Chromosomes, Human, Pair 4', 'DNA', 'Dihydropteridine Reductase', 'Humans', 'Karyotyping', 'Molecular Sequence Data', 'NADH, NADPH Oxidoreductases', 'Nucleic Acid Hybridization'] | 3,666,748 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E01.370.225.500.385.130', 'E01.370.225.500.620.670.130', 'E01.370.225.750.600.670.130', 'E05.200.500.385.130', 'E05.200.500.620.670.130', 'E05.200.750.600.670.130', 'E05.242.385.130', 'E05.393.285.130'], ['E05.393.183'], ['A11.284.187.520.300.280.285', 'G05.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Evaluation of in vitro antioxidant, antiglycation and antimicrobial potential of indigenous Myanmar medicinal plants. | OBJECTIVE: Myanmar has a long history of using medicinal plants for treatment of various diseases. To the best of our knowledge there are no previous reports on antiglycation activities of medicinal plants from Myanmar. Therefore, this study was aimed to evaluate the antioxidant, antiglycation and antimicrobial propert... | ['Anti-Bacterial Agents', 'Anti-Infective Agents', 'Antioxidants', 'Bacteria', 'Biphenyl Compounds', 'Candida albicans', 'Fruit', 'Garcinia', 'Glycation End Products, Advanced', 'Humans', 'Magnoliopsida', 'Medicine, Traditional', 'Melia', 'Myanmar', 'Nitric Oxide', 'Oxidative Stress', 'Phenols', 'Phytotherapy', 'Picrat... | 30,120,077 | [['D27.505.954.122.085'], ['D27.505.954.122'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['B03'], ['D02.455.426.559.389.185'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.650.940.800.575.912.250.859.625.333'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 |
Relationship of IL-1 and TNF-á polymorphisms with Helicobacter pylori in gastric diseases in a Brazilian population. | It is well known that the risk of development of gastric cancer (GC) in Helicobacter pylori-infected patients depends on several factors. Thus, the aim of this study was to investigate the effect of proinflammatory cytokine gene polymorphisms for IL-1â, IL-1RN and TNF-á on the development of GC in a Brazilian populatio... | ['Adult', 'Aged', 'Aged, 80 and over', 'Alleles', 'Brazil', 'Chronic Disease', 'DNA, Bacterial', 'Female', 'Gastritis', 'Genetic Predisposition to Disease', 'Genotype', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Interleukin 1 Receptor Antagonist Protein', 'Interleukin-1beta', 'Male', 'Middle Aged', 'P... | 22,714,811 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G05.360.340.024.340.030'], ['Z01.107.757.176'], ['C23.550.291.500'], ['D13.444.308.212'], ['C06.405.205.697', 'C06.405.748.398'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['C01.150.252.400.466'], ['B03.440.500.550', 'B03.660.150.235.500.250.5... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
[Two cases of patients with hepatocellular carcinoma (HCC) that developed in cryptogenic cirrhosis suggestive of nonalcoholic steatohepatitis (NASH) as background liver disease after clinical courses of 26 years]. | We report two cases of patients with hepatocellular carcinoma (HCC) that developed in cryptogenic cirrhosis suggestive of nonalcoholic steatohepatitis (NASH) as background liver disease. Case 1 was a 68-year-old woman, and case 2 was a 46-year-old man. They were admitted to our department for evaluation and treatment o... | ['Aged', 'Carcinoma, Hepatocellular', 'Fat Necrosis', 'Fatty Liver', 'Female', 'Humans', 'Liver Cirrhosis', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Time Factors'] | 17,485,950 | [['M01.060.116.100'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['C23.550.717.365'], ['C06.552.241'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.630', 'C23.550.355.412'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['M01.060.116.630'], ['G01.910.857... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The reproductive effects of dietary heptachlor in mink (Mustela vison). | Adult female mink were fed diets containing 0 (control), 6.25, 12.5, and 25 ppm (micrograms/g) technical grade heptachlor prior to and throughout the reproductive period (181 days) to evaluate the effects of heptachlor consumption on reproduction and offspring viability and to assess the extent of placental and mammary... | ['Animals', 'Animals, Newborn', 'Body Burden', 'Body Weight', 'Eating', 'Female', 'Heptachlor', 'Lethal Dose 50', 'Male', 'Mink', 'Pregnancy', 'Reproduction'] | 8,466,297 | [['B01.050'], ['B01.050.050.282'], ['E05.799.638.231', 'N06.850.460.200'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G07.203.650.283', 'G10.261.330'], ['D02.455.526.439.516'], ['E05.940.402', 'G07.225.500', 'G07.690.773.875.750', 'G07.690.936.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Preclinical investigation of alpha 1-acid glycoprotein (orosomucoid)]. | The molecular properties of alpha 1-acid glycoprotein are briefly discussed. This molecule has been shown in in vitro experiments to have both a stabilizing effect on vascular permeability and antiinflammatory properties. We were able to demonstrate these two effects in vivo in guinea pigs (skin, Evan's Blue extravasat... | ['Animals', 'Anti-Inflammatory Agents', 'Brain', 'Capillary Permeability', 'Cerebrovascular Disorders', 'Drug Evaluation, Preclinical', 'Edema', 'Guinea Pigs', 'Neutrophils', 'Orosomucoid', 'Rats'] | 10,226,349 | [['B01.050'], ['D27.505.954.158'], ['A08.186.211'], ['G03.143.330', 'G09.330.165'], ['C10.228.140.300', 'C14.907.253'], ['E05.290.750', 'E05.337.550'], ['C23.888.277'], ['B01.050.150.900.649.313.992.550'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.583', 'A15.382.490.315.583', 'A15.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Injuries related to logging: epidemiology, etiology and implications for prevention. | This article describes our study of 36 male patients who were brought to Ruby Memorial Hospital in Morgantown for treatment of non-fatal logging-related injuries. The type and severity of their injuries is described, as well as the host, vehicular/mechanical and environmental factors contributing to the injuries. The s... | ['Accidents, Occupational', 'Adult', 'Aged', 'Aged, 80 and over', 'Craniocerebral Trauma', 'Extremities', 'Humans', 'Injury Severity Score', 'Male', 'Middle Aged', 'Trees', 'West Virginia'] | 8,993,196 | [['N06.850.135.240'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.900.300', 'C26.915.300'], ['A01.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.940.968.875.500', 'E05.944.600', 'N04.452.859.564.800.500', 'N05.715.360.300.715.500.800.400'], ['M01.060.116.630'], ['B01.650.... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Acute coronary vasospasm in a patient with eosinophilic granulomatosis with polyangiitis following NSAID administration: A case report. | Eosinophilic with polyangiitis (EGPA, formerly known as Churg-Strauss syndrome) is a rare systemic disease characterized by a small-vessel necrotizing vasculitis. Cardiac manifestations are broad-ranging and are associated with a poor prognosis. Coronary vasospasm is uncommon.Here, we report a case of an acute coronary... | ['Acute Disease', 'Adrenal Cortex Hormones', 'Adult', 'Anti-Inflammatory Agents, Non-Steroidal', 'Churg-Strauss Syndrome', 'Coronary Vasospasm', 'Electrocardiography', 'Humans', 'Male'] | 27,893,661 | [['C23.550.291.125'], ['D06.472.040'], ['M01.060.116'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['C14.907.940.897.249.249', 'C15.604.515.292.015', 'C20.111.193.500'], ['C14.280.647.250.295', 'C14.907.585.250.295'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Direct measurement of oligonucleotide binding stoichiometry of gene V protein by mass spectrometry. | The binding stoichiometry of gene V protein from bacteriophage f1 to several oligonucleotides was studied using electrospray ionization-mass spectrometry (ESI-MS). Using mild mass spectrometer interface conditions that preserve noncovalent associations in solution, gene V protein was observed as dimer ions from a 10 mM... | ['Base Sequence', 'DNA-Binding Proteins', 'Macromolecular Substances', 'Mass Spectrometry', 'Molecular Sequence Data', 'Oligodeoxyribonucleotides', 'Poly A', 'Poly T', 'Protein Binding', 'Structure-Activity Relationship', 'Viral Proteins'] | 8,692,937 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.260'], ['D05'], ['E05.196.566'], ['L01.453.245.667'], ['D13.695.578.424.450'], ['D13.695.578.550.500'], ['D13.695.578.500.600'], ['G02.111.679', 'G03.808'], ['G02.111.830', 'G07.690.773.997'], ['D12.776.964']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Differential activation of NF-kappa B and AP-1 in increased fibronectin synthesis in target organs of diabetic complications. | Increased extracellular matrix protein production leading to structural abnormalities is a characteristic feature of chronic diabetic complications. We previously showed that high glucose in endothelial cell culture leads to the upregulation of basement membrane protein fibronectin (FN) via an endothelin (ET)-dependent... | ['Actins', 'Animals', 'DNA, Complementary', 'Diabetes Mellitus, Experimental', 'Electrophoretic Mobility Shift Assay', 'Endothelin-1', 'Fibronectins', 'Kidney', 'Male', 'Myocardium', 'NF-kappa B', 'Nuclear Proteins', 'RNA', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Retina', 'Reverse Transcriptase Polymerase Ch... | 12,582,013 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['E05.196.401.500'], ['D12.644.276.400.225', 'D12.776.467.400.225', 'D23.529.400.225'], ['D12.776... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Separation and characterization of adjuvant oligosaccharide oleate ester derived from product mixture of mannitol-oleic acid esterification. | Nearly 30 years after intense investigations of mannide monooleates for use as vaccine adjuvants, a novel adjuvant-active saccharide oleate ester was isolated and identified from the product mixture synthesized from mannitol and oleic acid. The mixture, which contained many kinds of mannide mono- and dioleates and thei... | ['Adjuvants, Immunologic', 'Algorithms', 'Animals', 'Antigens', 'Body Weight', 'Chemical Phenomena', 'Chemistry, Physical', 'Chromatography, High Pressure Liquid', 'Chromatography, Liquid', 'Chromatography, Thin Layer', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Glycolipids', 'Immunoglobulin G', 'Lipopolysaccharid... | 15,246,616 | [['D27.505.696.477.067'], ['G17.035', 'L01.224.050'], ['B01.050'], ['D23.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G02'], ['H01.181.529'], ['E05.196.181.400.300'], ['E05.196.181.400'], ['E05.196.181.400.537'], ['E05.478.566.350.170', 'E... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Ultrasonographic parameters of fetal well-being and development in alpacas. | In this study, a database of fetal and maternal parameters was developed in pregnant alpacas from 120 days of gestation to term for evaluation of fetal well-being and development. Ten pregnancies were examined every 2 weeks from 120 to 300 days of gestation, then weekly until parturition. Five more pregnancies were eva... | ['Animals', 'Camelids, New World', 'Female', 'Fetal Development', 'Pregnancy', 'Ultrasonography, Prenatal'] | 23,598,153 | [['B01.050'], ['B01.050.150.900.649.313.500.190.090'], ['G07.345.500.325.235', 'G08.686.784.170.157'], ['G08.686.784.769'], ['E01.370.350.850.865', 'E01.370.378.630.865']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A Green Sequential Injection Spectrophotometric Approach Using Natural Reagent Extracts from Heartwood of Ceasalpinia sappan Linn. for Determination of Aluminium. | A cost-effective and environmentally friendly approach using a simple sequential injection spectrophotometric system with a non-synthetic reagent from plant extracts was proposed for a green analytical-chemistry methodology. The crude aqueous extracts from heartwood of Ceasalpinia sappan Linn. in acetate buffer pH 5.5 ... | ['Aluminum', 'Benzopyrans', 'Beverages', 'Caesalpinia', 'Green Chemistry Technology', 'Hydrogen-Ion Concentration', 'Indenes', 'Limit of Detection', 'Pharmaceutical Preparations', 'Plant Extracts', 'Spectrophotometry', 'Water Pollutants, Chemical', 'Wood'] | 26,960,614 | [['D01.268.557.050', 'D01.552.547.050'], ['D03.383.663.283', 'D03.633.100.150'], ['G07.203.100', 'J02.200'], ['B01.650.940.800.575.912.250.401.093'], ['J01.897.360'], ['G02.300'], ['D02.455.426.559.847.486', 'D04.615.486'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['D26'], ['D20.21... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Activation of the Ca(2+)-activated nonselective cation channel by diacylglycerol analogues in rat cardiomyocytes. | INTRODUCTION: Cardiac hypertrophy is associated with changes in electrophysiologic properties due to ionic channel modifications and increases in protein kinase C (PKC) activity and diacylglycerol (DAG) content. These changes may contribute to an increased propensity for arrhythmia. Similar electrophysiologic modificat... | ['Animals', 'Calcium Channels', 'Carcinogens', 'Cell Differentiation', 'Diglycerides', 'Enzyme Activation', 'Heart Ventricles', 'Male', 'Membrane Potentials', 'Models, Animal', 'Models, Cardiovascular', 'Myocardium', 'Myocytes, Cardiac', 'Potassium Channels, Calcium-Activated', 'Protein Kinase C', 'Rats', 'Rats, Wistar... | 15,030,426 | [['B01.050'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['D27.888.569.100'], ['G04.152'], ['D10.351.303'], ['G02.111.263', 'G03.328'], ['A07.541.560'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.598'], ['E05.599.395.161'], ['A02.633.580', 'A07.541.704', 'A10... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
A novel non-synonymous mutation in the melanocortin-4 receptor gene (MC4R) in a 2-year-old Austrian girl with extreme obesity. | BACKGROUND: Functionally relevant mutations in the melanocortin-4 receptor gene ( MC4R) currently display the most common major gene/allele effect on extreme obesity.OBJECTIVE: Mutation screen of the MC4R in consecutively ascertained Austrian children and adolescents with severe obesity, to analyse the phenotype of mut... | ['Adolescent', 'Adult', 'Animals', 'Anticarcinogenic Agents', 'Austria', 'Body Fat Distribution', 'Bone Density', 'COS Cells', 'Child', 'Child, Preschool', 'Chlorocebus aethiops', 'Female', 'Gene Expression', 'Glucose Tolerance Test', 'Humans', 'Male', 'Middle Aged', 'Mutation, Missense', 'Obesity, Morbid', 'Pedigree',... | 17,286,227 | [['M01.060.057'], ['M01.060.116'], ['B01.050'], ['D27.505.696.706.018', 'D27.505.954.248.125', 'D27.720.799.018'], ['Z01.542.088'], ['E01.370.600.115.100.062', 'G02.111.130.134', 'G03.180.134', 'G07.100.049.134'], ['G11.427.100'], ['A11.251.210.172.500', 'A11.329.228.220'], ['M01.060.406'], ['M01.060.406.448'], ['B01.0... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Communication: Electron ionization of DNA bases. | No reliable experimental data exist for the partial and total electron ionization cross sections for DNA bases, which are very crucial for modeling radiation damage in genetic material of living cell. We have measured a complete set of absolute partial electron ionization cross sections up to 500 eV for DNA bases for t... | ['Electrons', 'Hydrogen Cyanide', 'Ions', 'Oxidation-Reduction', 'Purines', 'Pyrimidinones'] | 27,131,520 | [['G01.249.335', 'G01.358.500.750'], ['D01.029.260.330', 'D01.625.400'], ['D01.248.497'], ['G02.700', 'G03.295.531'], ['D03.633.100.759'], ['D03.383.742.698']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Temperature-sensitive modification and restriction phenotypes of an Escherichia coli dnaD mutant. | A mutant of Escherichia coli temperature-sensitive for deoxyribonucleic acid synthesis, dnaD, was found to have temperature-sensitive modification and restriction phenotypes. In contrast to the original observation by Carl (1970), the mutant could support the growth of lambda phage at 41 C. However, the lambda phages t... | ['Coliphages', 'DNA Viruses', 'DNA, Bacterial', 'Escherichia coli', 'Lysogeny', 'Mutation', 'Phenotype', 'Temperature'] | 4,605,206 | [['B04.123.205'], ['B04.280'], ['D13.444.308.212'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.935.500', 'G06.920.877.500'], ['G05.365.590'], ['G05.695'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Improving cardiac resynchronization therapy response with multipoint left ventricular pacing: Twelve-month follow-up study. | BACKGROUND: Cardiac resynchronization therapy (CRT) with multipoint left ventricular (LV) pacing (MultiPoint™ Pacing [MPP], St. Jude Medical) improves acute LV function and LV reverse remodeling at 3 months.OBJECTIVE: The purpose of this study was to test the hypothesis that MPP can also improve LV function at 12 month... | ['Aged', 'Cardiac Pacing, Artificial', 'Cardiac Resynchronization Therapy', 'Echocardiography', 'Female', 'Follow-Up Studies', 'Heart Ventricles', 'Humans', 'Male', 'Ventricular Function, Left'] | 25,678,057 | [['M01.060.116.100'], ['E02.331.200'], ['E02.331.200.500'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.330.955.800']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Provirus integration at the 3' region of N-myc in cell lines established from thymic lymphomas spontaneously formed in AKR mice and a [(BALB/c x B6)F1----AKR] bone marrow chimera. | Among 18 thymic leukemia cell lines which have been established from spontaneous thymic lymphomas in AKR mice as well as in bone marrow chimeras which were constructed by transplanting allogeneic bone marrow cells into irradiated AKR mice, three proviral integration sites were identified; near c-myc, N-myc and pim-1 lo... | ['Antigens, Surface', 'Base Sequence', 'Blotting, Northern', 'Blotting, Southern', 'Cell Line', 'Chimera', 'DNA', 'Down-Regulation', 'Gene Rearrangement', 'Genes, myc', 'Lymphoma', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Proviruses', 'RNA, Messenger', 'Sequence Homology, Nucleic Acid', 'Thymus Neoplasm... | 1,900,822 | [['D23.050.301'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['A11.251.210'], ['B05.200'], ['D13.444.308'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.344'], ['G05.360.340.024.340.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. | Grancalcin is a recently described Ca(2+)-binding protein especially abundant in human neutrophils. Grancalcin belongs to the penta-EF-hand subfamily of EF-hand proteins, which also comprises calpain, sorcin, peflin, and ALG-2. Penta-EF-hand members are typified by two novel types of EF-hands: one that binds Ca(2+) alt... | ['Calcium', 'Calcium-Binding Proteins', 'Fluorescent Dyes', 'Humans', 'Membrane Glycoproteins', 'Microfilament Proteins', 'Neutrophils', 'Phosphoproteins', 'Protein Binding'] | 11,279,160 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.157.125'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550', 'D12.776.543.550'], ['D05.750.078.730', 'D12.776.220.525'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sudden natural death in driving: case studies in the western area of Kanagawa. | To assess their incidence and implications, we made a retrospective study of sudden unexpected natural deaths during driving that occurred in the five year-period between 1992 and 1997. During that period, 188 postmortem examinations were performed on driver victims of traffic accidents. Of these, 15 (8%) were found to... | ['Accidents, Traffic', 'Adult', 'Aged', 'Automobile Driving', 'Cause of Death', 'Death, Sudden', 'Female', 'Forensic Medicine', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Retrospective Studies'] | 10,077,978 | [['N06.850.135.392'], ['M01.060.116'], ['M01.060.116.100'], ['I03.125'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['C23.550.260.322'], ['H02.403.330', 'I01.198.780.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.63... | ['Health Care [N]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
The slug mucosal irritation (SMI) assay: development of a screening tool for the evaluation of ocular discomfort caused by shampoos. | In this research, the slug mucosal irritation (SMI) assay was applied to predict ocular discomfort caused by shampoos to investigate the correlation between responses in slugs and humans. Several SMI experiments and a human eye irritation test (HEIT) were performed with 1 artificial tear solution (ArtTear) and 5 shampo... | ['Adult', 'Animals', 'Cross-Over Studies', 'Double-Blind Method', 'Eye', 'Female', 'Gastropoda', 'Hair Preparations', 'Humans', 'Irritants', 'Male', 'Middle Aged', 'Mucus', 'Predictive Value of Tests', 'Reproducibility of Results', 'Surface-Active Agents', 'Toxicity Tests', 'Young Adult'] | 21,741,469 | [['M01.060.116'], ['B01.050'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['A01.456.505.420', 'A09.371'], ['B01.050.500.644.400'], ['D27.720.269.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype. | Although clinical features, cytogenetics, and mutations are widely used to predict prognosis in patients with acute myeloid leukemia (AML), further refinement of risk stratification is necessary for optimal treatment, especially in cytogenetically normal (CN) patients. We sought to generate a simple gene expression sig... | ['Female', 'Humans', 'Karyotyping', 'Leukemia, Myeloid, Acute', 'Male', 'Middle Aged', 'Prognosis', 'RNA, Messenger', 'Survival Analysis'] | 26,517,675 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.475'], ['C04.557.337.539.275'], ['M01.060.116.630'], ['E01.789'], ['D13.444.735.544'], ['E05.318.740.998', 'N05.715.360.750.795', 'N06.850.520.830.998']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)? | We analyzed bone mineral density (BMD) in skulls of polar bears (Ursus maritimus) (n = 139) from East Greenland sampled during 1892-2002. Our primary goal was to detect possible changes in bone mineral content (osteopenia) due to elevated exposure to organochlorine [polychlorinated biphenyls (PCBs), dichlorodiphenyl tr... | ['Animals', 'Bone Density', 'Environmental Exposure', 'Female', 'Femur', 'Greenland', 'Hydrocarbons, Chlorinated', 'In Vitro Techniques', 'Male', 'Skull', 'Ursidae'] | 15,579,418 | [['B01.050'], ['G11.427.100'], ['N06.850.460.350'], ['A02.835.232.043.150'], ['Z01.107.567.403', 'Z01.542.816.124.500', 'Z01.639.400'], ['D02.455.526.439'], ['E05.481'], ['A02.835.232.781'], ['B01.050.150.900.649.313.750.250.761']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Interferon modulates glucose-sensitive neurons in the hypothalamus. | Interferon-alpha (IFN) therapy induces feeding suppression that resembles anorexia. The hypothalamic glucose-sensitive neurons engage in feeding behavior. Coronal sections of rat brains, containing both the lateral hypothalamus (LH) and the ventromedial hypothalamus (VMH), as well as single-cell recordings were used to... | ['Animals', 'Anorexia', 'Glucose', 'Hypothalamic Area, Lateral', 'Hypothalamus, Middle', 'In Vitro Techniques', 'Interferon-alpha', 'Neurons', 'Rats', 'Rats, Wistar'] | 9,372,301 | [['B01.050'], ['C23.888.821.108'], ['D09.947.875.359.448'], ['A08.186.211.180.497.300', 'A08.186.211.200.317.357.300'], ['A08.186.211.180.497.352', 'A08.186.211.200.317.357.352'], ['E05.481'], ['D12.644.276.374.440.890.250', 'D12.776.467.374.440.890.250', 'D23.529.374.440.890.250'], ['A08.675', 'A11.671'], ['B01.050.15... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Protein-energy malnutrition as the first manifestation of cystic fibrosis in infancy. | BACKGROUND: The protein-energy malnutrition (PEM) that is characterized by hypoproteinemia, edema, and anemia has been reported in 5-13% of infants with cystic fibrosis (CF). Due to the surprising higher incidence of PEM as the first presenting manifestation of CF in Macedonia, the aim of the present study was to evalu... | ['Comorbidity', 'Cystic Fibrosis', 'Female', 'Greece', 'Hospitals, University', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Protein-Energy Malnutrition', 'Risk Factors'] | 19,419,506 | [['N05.715.350.225', 'N06.850.490.687'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['Z01.542.383'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C18.654.521.500.708.626'], ['E05.318.740.600.800.725', 'N05.715... | ['Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Glucose diffusivity in multicellular tumor spheroids. | In order to understand the role of glucose limitations in controlling multicellular tumor spheroid growth, knowledge of the glucose diffusion coefficient is essential. The effective diffusivity of glucose in spheroids of rodent and human tumor cell lines has been determined by measuring the efflux of tritium labeled L-... | ['Algorithms', 'Animals', 'Carcinoma, Squamous Cell', 'Colonic Neoplasms', 'Diffusion', 'Glucose', 'Humans', 'Mammary Neoplasms, Experimental', 'Mice', 'Time Factors', 'Tumor Cells, Cultured'] | 3,383,189 | [['G17.035', 'L01.224.050'], ['B01.050'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['G01.202', 'G02.196'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.40... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Simultaneous determination of nicotine and cotinine in plasma using capillary column gas chromatography with nitrogen-sensitive detection. | A rapid and sensitive method is described for the stimultaneous determination of nicotine and its principal metabolite, cotinine, in plasma. A one-step extraction procedure is employed and the quantitative analyses are performed by capillary column gas chromatography using a thermionic specific detector. Other special ... | ['Chromatography, Gas', 'Cotinine', 'Humans', 'Nicotine', 'Pyrrolidinones', 'Reference Standards'] | 7,153,278 | [['E05.196.181.349'], ['D03.383.773.812.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.760.570', 'D03.383.725.518'], ['D03.383.773.812'], ['E05.978.808']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Survival strategies of yeast and filamentous fungi against the antifungal protein AFP. | The activities of signaling pathways are critical for fungi to survive antifungal attack and to maintain cell integrity. However, little is known about how fungi respond to antifungals, particularly if these interact with multiple cellular targets. The antifungal protein AFP is a very potent inhibitor of chitin synthes... | ['Antifungal Agents', 'Aspergillus', 'Calcium', 'Cell Wall', 'Chitin', 'Fungal Proteins', 'Fungi', 'Gene Deletion', 'Models, Genetic', 'Organic Chemicals', 'Phenotype', 'Polymers', 'Saccharomyces cerevisiae', 'Signal Transduction', 'Transcription, Genetic'] | 21,343,301 | [['D27.505.954.122.136'], ['B01.300.381.081'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.284.183'], ['D05.750.078.139', 'D09.698.211'], ['D12.776.354'], ['B01.300'], ['G05.365.590.762.320', 'G05.558.800.320'], ['E05.599.395.397'], ['D02'], ['G05.695'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['B01... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The natural history of congenital disease of the hip. | Fifty-four adults with eighty hips affected by congenital disease which had not been treated have been reviewed. Fifty-nine per cent of forty-two dislocated hips had fair or poor grading scores. The incidence of osteoarthritis was markedly increased in the presence of a well-developed false acetabulum. Unilateral dislo... | ['Acetabulum', 'Adult', 'Back Pain', 'Bone Diseases, Developmental', 'Female', 'Hip Dislocation, Congenital', 'Hip Joint', 'Humans', 'Indians, North American', 'Knee Joint', 'Lumbar Vertebrae', 'Osteoarthritis', 'Pain', 'Prognosis', 'Radiography', 'Spondylitis'] | 158,025 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Angiotensin type 1 receptor blockade prevents endocardial dysfunction of rapidly paced atria in rats. | INTRODUCTION: Atrial fibrillation (AF) per se causes atrial endocardial dysfunction leading to local coagulation imbalance on the internal surface of the atrium, which contributes to thrombus formation in the fibrillating left atrium.MATERIALS AND METHODS: To test a hypothesis that blockade of angiotensin II type 1 rec... | ['Angiotensin II Type 1 Receptor Blockers', 'Animals', 'Atrial Fibrillation', 'Cardiac Pacing, Artificial', 'Dose-Response Relationship, Drug', 'Down-Regulation', 'Endocardium', 'Heart Atria', 'Heart Diseases', 'Imidazoles', 'Immunohistochemistry', 'Lipoproteins', 'Myocardium', 'Nitric Oxide Synthase Type III', 'Plasmi... | 17,907,100 | [['D27.505.519.162.500'], ['B01.050'], ['C14.280.067.198', 'C23.550.073.198'], ['E02.331.200'], ['G07.690.773.875', 'G07.690.936.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A07.541.207'], ['A07.541.358'], ['C14.280'], ['D03.383.129.308'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Recurrent spontaneous compartment syndrome of the thigh. | Acute comparment syndrome (ACS) is a surgical emergency, in which tissue pressure becomes greater than perfusion pressure leading to tissue ischaemia. It is typically a consequence of trauma. We present a case in which a patient suffers blunt trauma to the thigh, but develops ACS 2 years after this injury and consequen... | ['Adult', 'Compartment Syndromes', 'Diagnosis, Differential', 'Fasciotomy', 'Follow-Up Studies', 'Humans', 'Magnetic Resonance Angiography', 'Male', 'Skin Transplantation', 'Thigh', 'Wounds, Nonpenetrating'] | 25,150,230 | [['M01.060.116'], ['C05.651.180', 'C14.907.303'], ['E01.171'], ['E04.321'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500.500', 'E01.370.370.050.500'], ['E02.095.147.725.700', 'E04.680.275.850', 'E04.936.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Germ-line contribution of embryonic stem cells in chimeric mice: influence of karyotype and in vitro differentiation ability. | The effect of the karyotype and the ability to differentiate in vitro upon germ-line transmission by A3-1 embryonic stem (ES) cells in chimeric mice were examined. Germ-line transmission was confirmed in ES cells exhibiting 38% and more of the normal karyotype, but no chimeric mice and/or germ-line transmitters were ob... | ['Animals', 'Cell Differentiation', 'Chimera', 'Embryo, Mammalian', 'Fertilization in Vitro', 'Germ Cells', 'Karyotyping', 'Mice', 'Mice, Inbred C57BL', 'Stem Cells'] | 9,027,467 | [['B01.050'], ['G04.152'], ['B05.200'], ['A16.254'], ['E02.875.800.750', 'E05.820.800.750'], ['A05.360.490', 'A11.497'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.475'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of cholesterol and protein content on membrane fluidity and 3 beta-hydroxysteroid dehydrogenase activity in mitochondrial inner membranes of bovine adrenal cortex. | The steroid biosynthetic enzymes in the adrenal cortex are localised in endoplasmic reticulum and mitochondrial membranes. For some of the enzymes in endoplasmic reticulum the activity appears to be modulated by lipid fluidity, (21-hydroxysteroid hydroxylase and 3 beta-hydroxysteroid dehydrogenase). A mechanism for the... | ['3-Hydroxysteroid Dehydrogenases', 'Adrenal Cortex', 'Animals', 'Chick Embryo', 'Cholesterol', 'Endoplasmic Reticulum', 'Intracellular Membranes', 'Kinetics', 'Liposomes', 'Membrane Fluidity', 'Membrane Lipids', 'Membrane Proteins', 'Mitochondria', 'Spectrometry, Fluorescence', 'Substrate Specificity'] | 6,586,204 | [['D08.811.682.047.436.350'], ['A06.300.071.140'], ['B01.050'], ['A13.350.150', 'A16.331.200'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['A11.284.430.214.190.875.248'], ['A11.284.149.450', 'A11.284.835.514'], ['G01.374.661', 'G02.111.490'], ['D25.479.517', 'D26.255.260.517', 'J01.637.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Influence of octreotide and tamoxifen on tumor growth and liver metastasis in N-nitrosobis(2-oxopropyl)amine-induced pancreatic cancer in Syrian hamsters. | In prospective clinical trials single octreotide therapy or combined therapy with tamoxifen has improved the quality of life and survival time in patients with pancreatic cancer. In this study we analyzed the influence of octreotide and tamoxifen on tumor growth and liver metastases in chemically induced pancreatic ade... | ['Animals', 'Antineoplastic Agents, Hormonal', 'Carcinogens', 'Cricetinae', 'Incidence', 'Liver Neoplasms', 'Male', 'Mesocricetus', 'Nitrosamines', 'Octreotide', 'Pancreatic Neoplasms', 'Receptors, Estrogen', 'Receptors, Somatostatin', 'Tamoxifen'] | 11,251,370 | [['B01.050'], ['D27.505.954.248.169'], ['D27.888.569.100'], ['B01.050.150.900.649.313.992.635.075.250'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['B01.050.150.900.649.313.992.635.075.250.500'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Research of Improved Grey GM (1, 1) Model to Predict the Postprandial Glucose in Type 2 Diabetes. | Diabetes may result in some complications and increase the risk of many serious health problems. The purpose of clinical treatment is to carefully manage the blood glucose concentration. If the blood glucose concentration is predicted, treatments can be taken in advance to reduce the harm to patients. For this purpose,... | ['Blood Glucose', 'Blood Glucose Self-Monitoring', 'Computer Simulation', 'Diabetes Mellitus, Type 2', 'Diagnosis, Computer-Assisted', 'Humans', 'Least-Squares Analysis', 'Metabolic Clearance Rate', 'Models, Biological', 'Models, Statistical', 'Postprandial Period', 'Reproducibility of Results', 'Sensitivity and Specif... | 27,314,034 | [['D09.947.875.359.448.500'], ['E01.370.225.124.100.105', 'E01.370.374.100', 'E01.370.520.100', 'E02.900.950.500', 'E05.200.124.100.105'], ['L01.224.160'], ['C18.452.394.750.149', 'C19.246.300'], ['E01.158', 'L01.313.500.750.100.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.750.400', 'N05.715.36... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Sister chromatid exchanges in Down syndromes and normal human beings. | The BrdU-Giemsa method was used to analyze the frequency of SCEs in a group of five Down syndromes and in a group of five normal human beings. In total 25 second mitoses were scored for SCEs in each individual. Although Down syndromes exhibited a tendency to have higher rates of exchange than normal human beings the an... | ['Azure Stains', 'Bromodeoxyuridine', 'Chromatids', 'Crossing Over, Genetic', 'Down Syndrome', 'Female', 'Genetic Variation', 'Humans', 'Leukocytes', 'Male'] | 144,242 | [['D02.886.369.080', 'D03.633.300.783.080'], ['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['A11.284.430.106.279.345.190.160.175', 'G05.360.160.175'], ['G05.728.615.200'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['G05.365'], ['B01.050.150.90... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of fabrication parameters on the enzyme loading and sensor response of enzyme-carrying conductive polymer electrodes. | Hydrogen peroxide sensors where horseradish peroxidase (HRP) is incorporated into pyrrole/3-alkylsulfonate pyrrole copolymer films deposited on an SnO2 electrode (HRP/Py-PS electrode) were investigated with regard to the effects of the fabrication parameters (electropolymerization charge, deposition current density, an... | ['Electrodes', 'Enzymes, Immobilized', 'Hydrogen-Ion Concentration', 'Polymers'] | 12,769,361 | [['E07.305.250'], ['D08.811.180', 'D12.776.463.500'], ['G02.300'], ['D05.750', 'D25.720', 'J01.637.051.720']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Two diphosphonate-functionalized asymmetric polyoxomolybdates with catalytic activity for oxidation of benzyl alcohol to benzaldehyde. | Two asymmetric polyoxomolybdates Na(6){Mo(2)O(5)[(Mo(2)O(6))NH(3)CH(2)CH(2)CH(2)C(O)(PO(3))(2)](2)}·16H(2)O (1) and (NH(4))(7)Na{MoO(2)[(Mo(2)O(6))NH(3)CH(2)CH(2)CH(2)C(O)(PO(3))(2)]}(4)·H(2)O (2) have been synthesized by the reactions of alendronic acid with molybdate. Structure analysis revealed that the polyoxoanion... | ['Benzaldehydes', 'Benzyl Alcohol', 'Catalysis', 'Diphosphonates', 'Hydrogen Peroxide', 'Models, Molecular', 'Molecular Conformation', 'Molybdenum', 'Oxidation-Reduction', 'Spectroscopy, Fourier Transform Infrared'] | 21,773,601 | [['D02.047.222'], ['D02.033.160.100', 'D02.455.426.559.389.140.200.100'], ['G02.130'], ['D02.705.429.500'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['E05.599.595'], ['G02.111.570.820'], ['D01.268.556.555', 'D01.268.956.500', 'D01.552.544.555'], ['G02.700', 'G03.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Active immunization of broiler breeder cockerels against chicken inhibin accelerates puberty and prevents age-induced testicular involution. | Injection of quail and breeder hens with a recombinant protein antigen (MBP-cINA521)--a fusion of the bacterical maltose-binding protein (MBP) and a fragment of the alpha-subunit of chicken inhibin (cINA521)--accelerates puberty and enhances lay. Herein, the effects of this immunogen on reproductive responses in broile... | ['Aging', 'Animals', 'Body Weight', 'Carrier Proteins', 'Chickens', 'Inhibins', 'Male', 'Maltose-Binding Proteins', 'Organ Size', 'Recombinant Fusion Proteins', 'Reproduction', 'Sexual Maturation', 'Testis', 'Vaccination'] | 16,776,479 | [['G07.345.124'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D12.776.157'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D06.472.334.968', 'D06.472.699.337', 'D12.644.548.387', 'D12.776.395.439'], ['D12.776.097... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Management of a burn sustained as a result of contact with 2400 degrees F molten metal. | A case of burns of the right leg caused by immersion in molten metal at 2400 degrees F is presented. Management by standard excision and grafting yielded a good result. The importance of protective garments is stressed. | ['Accidents, Occupational', 'Adult', 'Burns', 'Debridement', 'Humans', 'Iron', 'Leg Injuries', 'Male', 'Metallurgy', 'Protective Clothing', 'Shoes', 'Skin Transplantation', 'Staphylococcal Infections', 'Wound Infection'] | 7,852,457 | [['N06.850.135.240'], ['M01.060.116'], ['C26.200'], ['E04.176'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['C26.558'], ['J01.576.655.875.400'], ['E07.700.600', 'J01.637.215.600', 'J01.637.708.560.875'], ['J01.637.215.800'], ['E02.095.147.725.700', 'E04.... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
The expansion and selection of T cell receptor alpha beta intestinal intraepithelial T cell clones. | In conventional mice, the T cell receptor (TCR) alpha beta+ CD8 alpha alpha+ and CD8 alpha beta+ subsets of the intestinal intraepithelial lymphocytes (IEL) constitute two subpopulations. Each comprise a few hundred clones expressing apparently random receptor repertoires which are different in individual genetically i... | ['Animals', 'Base Sequence', 'CD8-Positive T-Lymphocytes', 'Cell Division', 'Clone Cells', 'Epithelial Cells', 'Gene Rearrangement, beta-Chain T-Cell Antigen Receptor', 'Intestinal Mucosa', 'Lymphocyte Count', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C3H', 'Mice, Inbred DBA', 'Molecular Sequence Data', 'Polymerase ... | 8,625,988 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.353'], ['A11.436'], ['G05.344.801.211', 'G12.500.287.211'], ['A0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Significant frequency of MSH2/MSH6 abnormality in ovarian endometrioid carcinoma supports histotype-specific Lynch syndrome screening in ovarian carcinomas. | AIMS: Lynch syndrome screening in ovarian carcinoma is controversial. The aim of this study was to assess the frequency of deficient mismatch repair (dMMR) protein in a retrospective cohort enriched for non-high-grade serous carcinomas and its association with outcome within histological types.METHODS AND RESULTS: Tiss... | ['Adenocarcinoma, Clear Cell', 'Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Carcinoma, Endometrioid', 'Cohort Studies', 'Colorectal Neoplasms, Hereditary Nonpolyposis', 'DNA Mismatch Repair', 'DNA-Binding Proteins', 'Female', 'Gene Frequency', 'Humans', 'Immunohistochemistry', 'Kaplan-Meier Estimate', 'M... | 26,799,366 | [['C04.557.470.200.025.045'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['C04.557.470.200.025.240', 'C04.588.945.418.948.585.124', 'C13.351.500.056.630.705.331', 'C13.351.937.418.685.331', 'C13.351.937.418.875.200.124', 'C19.391.630.705.331'], ['E05.318.372.500.750', 'N05.715.360.3... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Effectiveness in learning complex problem solving and salivary ion indices of psychological stress and activation. | Following Hinton et al. (1992, Biol. Psychol. 33, 63-71) and Richter et al. (1995, Biol. Psychol. 39, 131-142) ionic concentration of [K+] in unstimulated saliva was predicted to rise with perceived challenge, while lowered [Na+] was expected when experiencing psychological stress (PS). Subjects had to learn an engagin... | ['Adult', 'Arousal', 'Female', 'Humans', 'Male', 'Mineralocorticoids', 'Potassium', 'Problem Solving', 'Saliva', 'Sodium', 'Stress, Psychological'] | 9,834,889 | [['M01.060.116'], ['F02.830.104', 'G11.561.035'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.399.472.673'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['F02.463.425.725', 'F02.463.785.810'], ['A12.200.666'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850',... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity. | Pyrido pyrimidinones are selective agonists of the human high affinity niacin receptor GPR109A (HM74A). They show no activity on the highly homologous low affinity receptor GPR109B (HM74). Starting from a high throughput screening hit the in vitro activity of the pyrido pyrimidinones was significantly improved providin... | ['Animals', 'Microsomes, Liver', 'Niacin', 'Pyrimidinones', 'Rats', 'Rats, Wistar', 'Receptors, G-Protein-Coupled', 'Receptors, Nicotinic', 'Structure-Activity Relationship'] | 20,724,150 | [['B01.050'], ['A11.284.835.540.541'], ['D03.066.515.475', 'D03.383.725.547.475'], ['D03.383.742.698'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D12.776.543.750.695'], ['D12.776.157.530.400.400.100.500', 'D12.776.543.550.450.500.100.500', 'D12.776.543.585.400.500.1... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Upstream and downstream cis-acting elements for cleavage at the L4 polyadenylation site of adenovirus-2. | A study of the cis-acting elements involved in the 3' end formation of the RNAs from the major late L4 family of adenovirus-2 was undertaken. Series of 5' or 3' end deletion mutants and mutants harboring either internal deletions or substitutions were prepared and assayed for in vitro cleavage. This first allowed the d... | ['Adenoviruses, Human', 'Base Sequence', 'Binding Sites', 'Enhancer Elements, Genetic', 'HeLa Cells', 'Humans', 'Molecular Sequence Data', 'Mutation', 'Poly A', 'RNA Splicing', 'RNA, Viral', 'Repetitive Sequences, Nucleic Acid', 'Transcription, Genetic'] | 8,121,807 | [['B04.280.030.500.350'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.360.340.024.340.137.750.249'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Preparative isolation and purification of zearalenone from rice culture by combined use of macroporous resin column and high-speed counter-current chromatography. | Zearalenone is one of the most harmful mycotoxins found in grains and there is a large demand for zearalenone substrate for research purposes. A new separation method was developed for the preparative purification of zearalenone from rice culture of Fusarium graminearum by utilizing macroporous resin column combined wi... | ['Adsorption', 'Cell Culture Techniques', 'Chromatography, High Pressure Liquid', 'Countercurrent Distribution', 'Ethanol', 'Fusarium', 'Oryza', 'Polystyrenes', 'Zearalenone'] | 30,776,614 | [['G01.030', 'G02.020'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['E05.196.181.400.300'], ['E05.196.181.400.555', 'E05.196.278'], ['D02.033.375'], ['B01.300.381.366'], ['B01.650.940.800.575.912.250.822.616'], ['D02.455.426.559.389.150.750.800.830', 'D05.750.716.579', 'D25.720.716.5... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Molecular cloning of goat Mannose 6-phosphate receptors, MPR 300 and 46. | Mannose 6-phosphate receptor proteins (MPR 300 and 46) are type 1 transmembrane glycoproteins that mediate transport of lysosomal enzymes to lysosomes. In a recent study we have purified both receptors from goat liver and raised antibodies. An ELISA method was developed that allowed quantification of both receptors in ... | ['Amino Acid Sequence', 'Animals', 'Biological Transport, Active', 'Cell Membrane', 'Chickens', 'Cloning, Molecular', 'Enzymes', 'Gene Library', 'Goats', 'Lysosomes', 'Molecular Sequence Data', 'Protein Structure, Tertiary', 'Receptor, IGF Type 2', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sequence Alignment'... | 15,115,910 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G03.143.310'], ['A11.284.149'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E05.393.220'], ['D08.811'], ['G05.360.325'], ['B01.050.150.900.649.313.500.380.513'], ['A11.284.430.214.190.875.190.550'], ['L01.453.245.667'], ['G02.111.570.820.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective study. | BACKGROUND: Hepatorenal syndrome (HRS) is a severe complication of cirrhosis and is associated with high mortality. Ornipressin and terlipressin are effective in treatment of HRS, but are not available in the USA. The efficacy of vasopressin (AVP) and octreotide (OCT) infusions, commonly utilized in the USA, in the tre... | ['Antidiuretic Agents', 'Arginine Vasopressin', 'Cohort Studies', 'Female', 'Hepatorenal Syndrome', 'Humans', 'Male', 'Middle Aged', 'Octreotide', 'Retrospective Studies'] | 15,956,066 | [['D27.505.696.560.249'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C06.552.465', 'C12.777.419.291', 'C13.351.968.419.291'], ['B01.050.150.900.6... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Daytime sleepiness: an epidemiological study of young adults. | OBJECTIVES: Although excessive daytime sleepiness is associated with increased risks for accidents, decreased productivity, and interpersonal difficulties, information on its epidemiology is scarce. This paper examines correlates of and suspected risk factors for daytime sleepiness from a longitudinal epidemiological s... | ['Adult', 'Circadian Rhythm', 'Depressive Disorder', 'Educational Status', 'Employment', 'Female', 'Humans', 'Male', 'Marital Status', 'Michigan', 'Random Allocation', 'Regression Analysis', 'Sleep', 'Sleep Wake Disorders', 'Snoring', 'Social Class'] | 9,357,347 | [['M01.060.116'], ['G07.180.562.190'], ['F03.600.300'], ['N01.824.196'], ['N01.824.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.315.500', 'I01.240.361.500', 'I01.880.853.150.423.500', 'N01.224.361.500', 'N01.824.308.500'], ['Z01.107.567.875.350.500', 'Z01.107.567.875.510.500'], ['E05.318.370.70... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Synchronous surgical removal of esophageal and pulmonary cancer by endoscopic mucosectomy and video-assisted lobectomy through minimal thoracotomy]. | Authors report a case of a 75 year old, male patient suffering from an early stage squamous esophageal cancer and a synchronous adenocarcinoma of the lung. The patient was operated on simultaneously at the same setting: the esophageal tumour was taken out by endoscopic mucosectomy, whereas the pulmonary cancer was remo... | ['Adenocarcinoma', 'Aged', 'Carcinoma, Squamous Cell', 'Endoscopy', 'Esophageal Neoplasms', 'Humans', 'Lung Neoplasms', 'Male', 'Neoplasms, Multiple Primary', 'Thoracoscopy', 'Thoracotomy', 'Video Recording'] | 9,254,373 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E01.370.388.250', 'E04.502.250'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', ... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Campylobacter jejuni infection associated with unpasteurized milk and cheese--Kansas, 2007. | On October 26, 2007, a family health clinic nurse informed the Kansas Department of Health and Environment (KDHE) that Campylobacter jejuni had been isolated from two ill persons from different families who were members of a closed community in a rural Kansas county. By October 29, 17 additional members of the communit... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Animals', 'Campylobacter Infections', 'Campylobacter jejuni', 'Cheese', 'Child', 'Child, Preschool', 'Dairying', 'Disease Outbreaks', 'Female', 'Food Contamination', 'Food Microbiology', 'Gastroenteritis', 'Humans', 'Infant', 'Kansas', 'Male', 'Middle Aged', 'Milk',... | 19,116,607 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['C01.150.252.400.177'], ['B03.440.180.425', 'B03.660.150.235.250.500.375'], ['G07.203.200.500.444', 'G07.203.300.350.300.444', 'J02.350.500.444', 'J02.500.350.300.444'], ['M01.060.406'], ['M01.060.406.448'], ['J01.040.246'], ... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
Assessing the role of tryptophan residues in the binding site. | Instead of looking at the interfacial area as a measure of the extent of a protein--protein recognition site, a new procedure has been developed to identify the importance of a specific residue, namely tryptophan, in the binding process. Trp residues which contribute more towards the free energy of binding have their a... | ['Amino Acid Sequence', 'Binding Sites', 'Crystallography, X-Ray', 'Molecular Structure', 'Protein Binding', 'Protein Structure, Secondary', 'Protein Structure, Tertiary', 'Structure-Activity Relationship', 'Tryptophan'] | 11,287,674 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['E05.196.309.742.225'], ['G02.111.570', 'G02.466'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709.600'], ['G02.111.570.820.709.610'], ['G02.111.830', 'G07.690.773.997'], ['D12.125.072.050.850', 'D12.125.142.875']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Imaging changes associated with cognitive abnormalities in Parkinson's disease. | The current study investigates both gray and white matter changes in non-demented Parkinson's disease (PD) patients with varying degrees of mild cognitive deficits and elucidates the relationships between the structural changes and clinical sequelae of PD. Twenty-six PD patients and 15 healthy controls (HCs) were enrol... | ['Aged', 'Analysis of Variance', 'Cerebral Cortex', 'Cognition Disorders', 'Diffusion Tensor Imaging', 'Executive Function', 'Female', 'Gray Matter', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Parkinson Disease', 'Psychiatric Status Rating Scales', 'White Matter... | 24,816,399 | [['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['A08.186.211.200.885.287.500'], ['F03.615.250'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['F02.463.217'], ['A08.186.211.168', 'A08.186.854.348'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
NMR studies of binding of 5-FdUDP and dCDP to ribonucleoside-diphosphate reductase from Escherichia coli. | 5-Fluoro-2'-deoxyuridine-5'-diphosphate (5-FdUDP) has been synthesised using an original route, previously applied to the synthesis of natural nucleoside diphosphates. The interaction between 5-FdUDP and the enzyme ribonucleoside-diphosphate reductase (EC 1.17.4.1) has been studied with 19F-NMR. The product analogue is... | ['Binding Sites', 'Deoxycytosine Nucleotides', 'Deoxyuracil Nucleotides', 'Escherichia coli', 'Floxuridine', 'Magnetic Resonance Spectroscopy', 'Ribonucleoside Diphosphate Reductase', 'Temperature'] | 7,696,321 | [['G02.111.570.120'], ['D03.383.742.686.246.425', 'D13.695.201.150', 'D13.695.740.246.425'], ['D03.383.742.686.850.210', 'D13.695.201.200', 'D13.695.740.850.210'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D03.383.742.680.852.300.350', 'D13.570.230.430.432', 'D13.570.685.852.300.350'], ['E05.196.867.519... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases. | Using a polyclonal antibody, a partial cDNA clone for rat aminopeptidase M was identified in a lambda gt11 library from rat kidney. A synthetic oligonucleotide probe derived from the sequence of the insert was used to screen a randomly primed lambda gt10 library. This allowed the identification of several overlapping c... | ['Amino Acid Sequence', 'Aminopeptidases', 'Animals', 'Base Sequence', 'Binding Sites', 'CD13 Antigens', 'Cloning, Molecular', 'Kidney', 'Metalloendopeptidases', 'Microbial Collagenase', 'Molecular Sequence Data', 'Multigene Family', 'Rats', 'Sequence Homology, Nucleic Acid', 'Thermolysin', 'Zinc'] | 2,567,164 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D08.811.277.656.350.100'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D08.811.277.656.350.100.160', 'D08.811.277.656.350.555.100', 'D08.811.277.656.675.555.100', 'D23.050.301.264.894.113', 'D23.101.100.894.113'], ['E05.39... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Acetabular and femoral reconstruction with impacted graft and cement. | Loosening of primary cemented and noncemented components of total hip arthroplasties always is accompanied by a loss of bone stock. There are several options for reconstruction of the acetabular and femoral defects. The authors' treatment of choice is a standardized cemented revision procedure with tight impaction of m... | ['Acetabulum', 'Adult', 'Aged', 'Bone Cements', 'Bone Substitutes', 'Female', 'Femur', 'Hip Prosthesis', 'Humans', 'Male', 'Middle Aged', 'Prosthesis Failure', 'Reoperation', 'Treatment Outcome'] | 8,595,745 | [['A02.835.232.043.825.108'], ['M01.060.116'], ['M01.060.116.100'], ['D05.750.716.822.300', 'D25.720.716.822.300', 'D27.720.102.158', 'J01.637.051.720.716.822.300'], ['D25.130.325', 'J01.637.051.130.325'], ['A02.835.232.043.150'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']... | ['Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. | OBJECTIVES: We sought to examine the hypothesis that a pharmacologic up-regulation of endothelial nitric oxide synthase (eNOS) combined with a reversal of eNOS uncoupling provides a protective effect against cardiovascular disease.BACKGROUND: Many cardiovascular diseases are associated with oxidant stress involving pro... | ['Animals', 'Endothelium, Vascular', 'Enzyme Inhibitors', 'Hypertension', 'Male', 'Nitric Oxide Synthase', 'Protein Kinase C', 'Rats', 'Rats, Inbred SHR', 'Rats, Inbred WKY', 'Staurosporine', 'Up-Regulation'] | 16,781,385 | [['B01.050'], ['A07.015.700.500', 'A10.272.491.355'], ['D27.505.519.389'], ['C14.907.489'], ['D08.811.682.664.500.772'], ['D08.811.913.696.620.682.700.725'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.300', 'B01.050.150.900.649.313.992.635.505.700.400.300'], ['B01.050.050.199.520.760.390', '... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early revision after hemiarthroplasty and osteosynthesis of cervical hip fracture: short-term function mortality unchanged in 102 patients. | BACKGROUND: There is no consensus on whether osteosynthesis or hemiarthroplasty is preferable in the treatment of cervical hip fractures. Osteosynthesis is associated with more reoperations than hemiarthroplasty but there is little information available on the consequences of these reoperations.PATIENTS AND METHODS: We... | ['Aged', 'Aged, 80 and over', 'Arthroplasty, Replacement, Hip', 'Female', 'Femoral Neck Fractures', 'Fracture Fixation, Internal', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Reoperation', 'Time Factors'] | 15,370,582 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['C26.404.061.425.500', 'C26.531.750.500', 'C26.558.276.425.500'], ['E04.555.300.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Search for microorganisms among collectable bacterial strains capable of transforming nucleosides into virazole]. | The ability of bacterial cultures to transform nucleosides to virazole, a riboside with antiviral activity, was studied. Qualitative and quantitative methods for estimation of the microbial activity in the biotransformation reaction were designed. A qualitative rapid method for analysis of a large number of cultures wa... | ['Adenosine', 'Antiviral Agents', 'Bacteria', 'Chromatography, Thin Layer', 'Culture Media', 'Guanosine', 'Hydrolysis', 'Inosine', 'Purine-Nucleoside Phosphorylase', 'Ribavirin', 'Ribose', 'Solutions', 'Spectrophotometry, Ultraviolet'] | 9,606,497 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D27.505.954.122.388'], ['B03'], ['E05.196.181.400.537'], ['D27.720.470.305', 'E07.206'], ['D03.633.100.759.590.454', 'D13.570.583.454', 'D13.570.800.453'], ['G02.380'], ['D03.633.100.759.590.616', 'D13.570.583.616', 'D13.570.800.573'], ['D08.811.913.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pharmacophoric features of Pseudomonas aeruginosa deacetylase LpxC inhibitors: an electronic and structural analysis. | Various electronic properties of structurally diverse synthetic LpxC inhibitors containing oxazoline, aroylserine and thiazoline rings were calculated and correlated with biological activity. These electronic features include the magnitude and locations of 3-dimensional molecular electrostatic potentials, hydrogen bond... | ['Amidohydrolases', 'Chemical Phenomena', 'Chemistry, Physical', 'Enzyme Inhibitors', 'Hydrogen Bonding', 'Models, Molecular', 'Pseudomonas aeruginosa', 'Structure-Activity Relationship'] | 17,188,864 | [['D08.811.277.087'], ['G02'], ['H01.181.529'], ['D27.505.519.389'], ['G02.282'], ['E05.599.595'], ['B03.440.400.425.625.625.100', 'B03.660.250.580.590.050'], ['G02.111.830', 'G07.690.773.997']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebo-controlled trial. | BACKGROUND: Diabetes is a leading cause of chronic kidney disease (CKD) worldwide. Optimum glycaemic control in patients with type 2 diabetes is important to minimise the risk of microvascular and macrovascular complications and to slow the progression of CKD. We assessed the efficacy and safety of empagliflozin as an ... | ['Benzhydryl Compounds', 'Diabetes Mellitus, Type 2', 'Double-Blind Method', 'Drug Therapy, Combination', 'Female', 'Glucosides', 'Humans', 'Hypoglycemic Agents', 'Male', 'Middle Aged', 'Renal Insufficiency, Chronic', 'Treatment Outcome'] | 24,795,251 | [['D02.455.426.559.389.115'], ['C18.452.394.750.149', 'C19.246.300'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.310'], ['D09.408.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['M01.060.116.630'], ['C12.777.419.780.750', 'C13.351.968.41... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Argyrophilic grain disease: synergistic component of dementia?]. | INTRODUCTION: Argyrophilic grain disease (AGD) is one cause of neurodegenerative dementia with a variable clinical spectrum. A neuropathology study is required for diagnosis.CASE REPORT: We report the case of a 68-year-old patient presenting with cognitive decline associating with frontal dysfunction and parkinsonism. ... | ['Aged', 'Basal Ganglia', 'Basal Ganglia Diseases', 'Cerebral Cortex', 'Cognition', 'Dementia', 'Fatal Outcome', 'Humans', 'Male', 'Neurodegenerative Diseases', 'Neurofibrillary Tangles', 'Parkinson Disease'] | 19,963,233 | [['M01.060.116.100'], ['A08.186.211.200.885.287.249'], ['C10.228.140.079'], ['A08.186.211.200.885.287.500'], ['F02.463.188'], ['C10.228.140.380', 'F03.615.400'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Determining appropriate healthcare bargaining units: NLRB's historic rule making move. | On August 25, 1974 the Taft-Hartley Amendments (Public Law 93-360) took effect and mandated that voluntary not-for-profit hospitals enter into the process of collective bargaining. The belated entrance of these hospitals into the process stems from a change in the Taft-Hartley Act of 1947 where the law specifically exe... | ['American Hospital Association', 'Collective Bargaining', 'Decision Making, Organizational', 'Government Agencies', 'Personnel Administration, Hospital', 'United States'] | 10,313,574 | [['N03.540.828.540.080'], ['N03.540.571.356', 'N04.452.677.356'], ['N04.452.190'], ['I01.409.418', 'N03.540.400'], ['N02.278.216.500.968.565', 'N04.452.442.452.422.565', 'N04.452.677.440'], ['Z01.107.567.875']] | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
A one-plate assay for macrophage bactericidal activity. | Human peripheral blood monocytes purified by counterflow centrifugal elutriation (CCE) showed an enhanced capacity to kill Listeria Monocytogenes and Staphylococcus aureus after activation with interferon-gamma (IFN gamma). Bactericidal activity was evaluated by a rapid colorimetric microassay based on the reduction of... | ['Blood Bactericidal Activity', 'Colorimetry', 'Coloring Agents', 'Humans', 'Immunologic Techniques', 'Interferon-gamma', 'Listeria monocytogenes', 'Macrophages', 'Oxidation-Reduction', 'Staphylococcus aureus', 'Tetrazolium Salts', 'Thiazoles'] | 3,928,761 | [['G09.188.100', 'G12.450.564.204'], ['E05.196.922.250'], ['D27.720.233'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', 'D23.529.374.480.615.350'], ['B03.353.500.5... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fusiform Gyrus Laterality in Writing Systems with Different Mapping Principles: An Artificial Orthography Training Study. | Writing systems vary in many ways, making it difficult to account for cross-linguistic neural differences. For example, orthographic processing of Chinese characters activates the mid-fusiform gyri (mFG) bilaterally, whereas the processing of English words predominantly activates the left mFG. Because Chinese and Engli... | ['Analysis of Variance', 'Brain Mapping', 'Female', 'Humans', 'Learning', 'Magnetic Resonance Imaging', 'Male', 'Neural Pathways', 'Neuropsychological Tests', 'Pattern Recognition, Visual', 'Photic Stimulation', 'Psycholinguistics', 'Reading', 'Temporal Lobe', 'Young Adult'] | 26,918,586 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['E01.370.350.825.500'], ['A08.612'], ['F04.711.513'], ['F02.463.593.524.500', 'F02.463.593.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Information Science [L]', 'Named Groups [M]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Adenosine receptor on human basophils: modulation of histamine release. | Adenosine, at physiologic concentrations, inhibits in vitro IgE-mediated human basophil histamine release in a dose-dependent fashion. The inhibition dose-response curve is paralleled by an adenosine-induced increase in cAMP levels of human leukocyte preparations. Further evidence that the adenosine effect is related t... | ['Adenosine', 'Adenylyl Cyclases', 'Basophils', 'Binding Sites', 'Cyclic AMP', 'Dose-Response Relationship, Immunologic', 'Histamine Release', 'Humans', 'Theophylline'] | 90,084 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Integrative FourD omics approach profiles the target network of the carbon storage regulatory system. | Multi-target regulators represent a largely untapped area for metabolic engineering and anti-bacterial development. These regulators are complex to characterize because they often act at multiple levels, affecting proteins, transcripts and metabolites. Therefore, single omics experiments cannot profile their underlying... | ['Carbon', 'Escherichia coli', 'Escherichia coli Proteins', 'Gene Expression Regulation', 'Gene Expression Regulation, Bacterial', 'Genomics', 'Metabolic Engineering', 'Metabolome', 'Metabolomics', 'Models, Biological', 'Proteome', 'Proteomics', 'RNA-Binding Proteins', 'Repressor Proteins', 'Stress, Physiological', 'Tr... | 28,126,921 | [['D01.268.150'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['G05.308'], ['G05.308.300'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['E05.393.420.526', 'E05.481.500.311.249', 'J01.293.069.249.249'], ['G03.500'], ['H01.158.201.586', 'H01.158.273.180.599', 'H01.181.122.638'], ['E0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
HaploSearch: a tool for haplotype-sequence two-way transformation. | Comparison of available mitochondrial DNA data is some times hindered by the data presentation format. HaploSearch is a simple tool for transforming DNA sequences into haplotype data and vice versa, speeding up the manipulation of large datasets. Although designed for mitochondrial DNA, HaploSearch could be used with a... | ['DNA, Mitochondrial', 'Haplotypes', 'Humans', 'Polymerase Chain Reaction', 'Sequence Analysis, DNA'] | 21,059,407 | [['D13.444.308.283.225'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.620.500'], ['E05.393.760.700']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Mr ZHENG Yugui's academic thoughts: in memory of the successor of Chengjiang acupuncture school in Shandong province]. | Mr ZHENG Yugui, a distinguished acupuncturist in Qilu area, is one of the successors of Chengjiang acupuncture school in Shandong province. Through collecting the papers and works concerning Mr ZHENG, the academic thoughts are summarized, including careful and clear differentiation of syndrome, specific and precise sel... | ['Acupuncture', 'Acupuncture Therapy', 'China', 'History, 20th Century', 'Humans', 'Schools'] | 27,344,842 | [['H02.004'], ['E02.190.044'], ['Z01.252.474.164'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.783', 'J03.832']] | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 |
Acute, subacute, and chronic myocardial infarction: quantitative comparison of 2D and 3D late gadolinium enhancement MR imaging. | PURPOSE: To assess a late gadolinium enhancement (LGE) single-breath-hold three-dimensional (3D) inversion recovery magnetic resonance (MR) imaging sequence for the quantification of myocardial scar mass and transmurality in comparison with a clinically established two-dimensional (2D) sequence.MATERIALS AND METHODS: A... | ['Acute Disease', 'Chi-Square Distribution', 'Chronic Disease', 'Contrast Media', 'Female', 'Humans', 'Image Enhancement', 'Imaging, Three-Dimensional', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Organometallic Compounds', 'Statistics, Nonparametric'] | 21,467,254 | [['C23.550.291.125'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['C23.550.291.500'], ['D27.505.259.500', 'D27.720.259'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Vitamin E and its effect on arterial stiffness in postmenopausal women--a randomized controlled trial. | INTRODUCTION: Arterial stiffness is emerging as a useful index of vascular health. Postmenopausal women have been shown to have stiffer arteries. Hormone replacement therapy and soy isoflavones improve arterial stiffness in these women. The aim of this study is to establish whether vitamin E improves arterial stiffness... | ['Antioxidants', 'Arteries', 'Blood Pressure', 'Cross-Over Studies', 'Dietary Supplements', 'Double-Blind Method', 'Female', 'Humans', 'Middle Aged', 'Placebos', 'Postmenopause', 'Treatment Outcome', 'Vascular Resistance', 'Vitamin E'] | 14,692,708 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A07.015.114'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['G07.203.300.456', 'J02.500.456'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Quantitative structure of the normal human placenta from 10 weeks of gestation to term. | Ninety five placentae from normal term and 'normal' preterm pregnancies have been analysed by morphometry. The growth of the whole placenta, of the microscopic placental constituents and of the villous surface area has been measured in placentae from uncomplicated pregnancies from 10 weeks of gestation to term to provi... | ['Chorionic Villi', 'Female', 'Fetus', 'Gestational Age', 'Growth', 'Humans', 'Placenta', 'Pregnancy'] | 6,745,150 | [['A10.615.284.473.200', 'A16.254.750.473.200', 'A16.710.189'], ['A16.378'], ['G07.345.500.325.235.968', 'G08.686.320'], ['G07.345.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A16.710'], ['G08.686.784.769']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of ethylene oxide in herbs, spices and other dried vegetables imported into Italy. | Gas chromatography-mass spectrometry was used to analyse ethylene oxide (EO) in 63 samples of dried vegetable materials for food use derived from import commodities and subjected to quality control for three food-transformation industries. EO residues were quantified through the determination of ethylene chlorohydrin (... | ['Commerce', 'Ethylene Chlorohydrin', 'Ethylene Oxide', 'Food Analysis', 'Food Handling', 'Italy', 'Spices', 'Vegetables'] | 24,320,017 | [['J01.219'], ['D02.033.260.350', 'D02.033.375.310'], ['D02.355.291.411.417'], ['E05.362', 'J01.576.423.850.100'], ['J01.576.423.200'], ['Z01.542.489'], ['G07.203.300.250.725', 'J02.500.250.725'], ['B01.650.160.956', 'B01.650.510.956', 'G07.203.300.850', 'J02.500.850']] | ['Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Ivor Lewis minimally invasive esophagectomy for esophageal cancer: An excellent operation that improves with experience. | OBJECTIVE: Esophagectomy is associated with major morbidity. In this study we sought to assess the learning curve of minimally invasive Ivor Lewis esophagectomy (MIILE) and to evaluate perioperative outcomes, including anastomotic leak and hospital readmission, as a function of graduated surgeon experience.METHODS: Dat... | ['Anastomotic Leak', 'Clinical Competence', 'Conversion to Open Surgery', 'Esophageal Neoplasms', 'Esophagectomy', 'Humans', 'Learning Curve', 'Patient Readmission', 'Reoperation', 'Retrospective Studies', 'Risk Factors', 'Time Factors', 'Treatment Outcome'] | 30,459,111 | [['C23.550.767.071'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E04.502.250.155'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['E04.210.346'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.784.629.529.274'], ['E02.760.400.620', 'N02.421.585.4... | ['Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Effects of glovebox gloves on grip and key pinch strength and contact forces for simulated manual operations with three commonly used hand tools. | UNLABELLED: This study examined the effects of glovebox gloves for 11 females on maximum grip and key pinch strength and on contact forces generated from simulated tasks of a roller, a pair of tweezers and a crescent wrench. The independent variables were gloves fabricated of butyl, CSM/hypalon and neoprene materials; ... | ['Adult', 'Biomechanical Phenomena', 'Female', 'Fingers', 'Gloves, Protective', 'Hand', 'Hand Strength', 'Humans', 'Pinch Strength', 'Task Performance and Analysis', 'Young Adult'] | 24,988,950 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['A01.378.800.667.430'], ['E07.700.600.400', 'J01.637.215.600.400', 'J01.637.708.560.875.400'], ['A01.378.800.667'], ['E01.370.600.425.500', 'G11.427.560.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.600.425.500.500', 'G11.427.560.500.500'], ['F02.78... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Estimation of total nitrogen transport and retention during flow in a catchment using a mass balance model incorporating the effects of land cover distribution and human activity information. | The load of total nitrogen (TN) in stream water was surveyed in the Nagara River Basin (2,000 km(2)), central Japan. Multivariate analysis placed the TN data in an environmental and social context, relating TN to land use conditions such as geologic features, population density, and percentage of the population using t... | ['Environmental Monitoring', 'Geological Phenomena', 'Humans', 'Japan', 'Models, Theoretical', 'Multivariate Analysis', 'Nitrogen', 'Population Density', 'Rivers', 'Socioeconomic Factors', 'Water Movements', 'Water Pollutants, Chemical'] | 20,962,399 | [['N06.850.460.350.080', 'N06.850.780.375'], ['G01.311'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['E05.599'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['D01.268.604', 'D01.362.625'], ['N01.224.600', 'N06.850.505.400.600'], ['G01.311.750... | ['Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Comparison between wait-and-see policy and elective neck dissection in clinically N0 cutaneous squamous cell carcinoma of head and neck. | To analyze the superiority of wait-and-see policy and elective neck dissection in treating cN0 patients with facial cutaneous cell carcinoma (cSCC).Patients with clinically negative parotid and neck metastasis disease were prospectively enrolled. Three groups were divided based on whether the patient received an operat... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Squamous Cell', 'Elective Surgical Procedures', 'Facial Neoplasms', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neck Dissection', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Parotid Gland', 'Parotid Neoplasms', ... | 29,851,784 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E04.249'], ['C04.588.443.392'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['E04.446.318', 'E04.580.411'], ['C04.697.6... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Modulation of tumoricidal function in alveolar macrophages from lung cancer patients by interleukin-6. | Previous studies have demonstrated that alveolar macrophages from lung cancer patients are impaired in their ability to develop tumoricidal function when stimulated by activators such as interferon gamma + lipopolysaccharide. However, these same macrophages have been shown to develop significant tumoricidal function wh... | ['Antibodies', 'Coculture Techniques', 'Cytokines', 'Cytotoxicity, Immunologic', 'Humans', 'Interferon-gamma', 'Interleukin-6', 'Lipopolysaccharides', 'Lung Neoplasms', 'Lymphocytes', 'Macrophage Activation', 'Macrophages, Alveolar', 'RNA, Messenger'] | 9,353,425 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['E05.481.500.374'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G12.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gene transfer of the costimulatory molecules B7-1 and B7-2 into human multiple myeloma cells by recombinant adeno-associated virus enhances the cytolytic T cell response. | Gene transfer of the costimulatory molecules B7-1 and B7-2 induces a potent antitumor immune response in a variety of tumor models. B cell neoplasms including multiple myeloma (MM) often show little or no expression of B7 antigens; they are therefore a potential target for this approach. To increase the expression of h... | ['Antigens, CD', 'B7-1 Antigen', 'B7-2 Antigen', 'Cells, Cultured', 'Combined Modality Therapy', 'Dependovirus', 'Gene Transfer Techniques', 'Genetic Therapy', 'Genetic Vectors', 'Humans', 'Immunotherapy', 'Interleukin-2', 'Kanamycin Kinase', 'Lymphocyte Activation', 'Membrane Glycoproteins', 'Multiple Myeloma', 'Phosp... | 9,282,174 | [['D23.050.301.264.035', 'D23.101.100.110'], ['D12.776.467.150.100', 'D12.776.543.095.100', 'D23.050.301.285.100', 'D23.529.168.100'], ['D12.776.465.500', 'D12.776.467.150.200', 'D12.776.543.095.200', 'D23.050.301.285.200', 'D23.529.168.200'], ['A11.251'], ['E02.186'], ['B04.280.580.650.170'], ['E05.393.350'], ['E02.09... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Purinergic signalling - a possible mechanism for KCNQ1 channel response to cell volume challenges. | AIM: A number of K(+) channels are regulated by small, fast changes in cell volume. The mechanisms underlying cell volume sensitivity are not known, but one possible mechanism could be purinergic signalling. Volume activated ATP release could trigger signalling pathways that subsequently lead to ion channel stimulation... | ['Adenosine', 'Adenosine Triphosphate', 'Animals', 'Aquaporin 1', 'Cell Size', 'Genes, Reporter', 'Humans', 'Ion Channel Gating', 'KCNQ1 Potassium Channel', 'Mechanotransduction, Cellular', 'Membrane Potentials', 'Oocytes', 'Osmotic Pressure', 'Patch-Clamp Techniques', 'Potassium Channels, Voltage-Gated', 'Purinergic A... | 22,805,606 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D12.776.157.530.400.500.040.374', 'D12.776.543.550.450.730.040.374', 'D12.776.543.585.400.730.040.436'], ['G04.325'], ['G05.360.340.024.340.435'], ['B01.050.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Purification and characterization of N-methylalanine dehydrogenase. | Cell free extracts of Pseudomonas MS previously have been shown to carry out the synthesis of a novel amino acid, N-methylalanine (Kung, H.F., and Wagner, C. (1970) Biochim. Biophys. Acta 201, 513-516). An enzyme has been isolated from this organism which is responsible for the synthesis of N-methylalanine. The stoichi... | ['Alanine', 'Amino Acid Oxidoreductases', 'Chromatography, DEAE-Cellulose', 'Chromatography, Gel', 'Hydrogen-Ion Concentration', 'Kinetics', 'Molecular Weight', 'NADP', 'Oxidation-Reduction', 'Pseudomonas', 'Structure-Activity Relationship'] | 236,301 | [['D12.125.042'], ['D08.811.682.664.500'], ['E05.196.181.400.383.349'], ['E05.196.181.400.250'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['G02.494'], ['D03.633.100.759.646.138.749', 'D08.211.625', 'D13.695.667.138.749', 'D13.695.827.068.749'], ['G02.700', 'G03.295.531'], ['B03.440.400.425.625.625', 'B03.660.250.58... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A comparison of the absorption of phenobarbitone given via the oral and the intramuscular route. | 6 patients were given 180mg phenobarbitone, and 1 patient 120mg, and the plasma levels measured within the first 4 hours or so. These doses of phenobarbitone were quite ineffective in achieving, in a reasonable time, the levels generally recognised as being protective against seizures. 5 patients were loaded with pheno... | ['Absorption', 'Administration, Oral', 'Adult', 'Epilepsy', 'Female', 'Humans', 'Injections, Intramuscular', 'Intestinal Absorption', 'Male', 'Middle Aged', 'Phenobarbital'] | 756,010 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['E02.319.267.100'], ['M01.060.116'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.460'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G10.261.353... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Association of digitalis treatment with outcomes following myocardial infarction in patients with heart failure or evidence of left ventricular dysfunction: an analysis from the High-Risk Myocardial Infarction Database Initiative. | BACKGROUND: Contradictory findings have been reported regarding the safety and efficacy of digitalis in patients recovering from acute myocardial infarction (MI). We studied the association of digitalis use with long-term and short-term prognosis in patients presenting with an acute MI complicated with heart failure (H... | ['Aged', 'Aged, 80 and over', 'Atrial Fibrillation', 'Cardiotonic Agents', 'Databases, Factual', 'Digitalis Glycosides', 'Female', 'Heart Failure', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Prognosis', 'Retrospective Studies', 'Time Factors', 'Treatment Outcome', 'Ventricular Dysfunction, Left'] | 28,455,597 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.067.198', 'C23.550.073.198'], ['D27.505.954.411.222', 'D27.720.799.080'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['D04.210.500.155.580.130.500', 'D09.408.180.261'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Design, synthesis and molecular docking of amide and urea derivatives as Escherichia coli PDHc-E1 inhibitors. | By targeting the ThDP binding site of Escherichia coli PDHc-E1, two new 'open-chain' classes of E. coli PDHc-E1 inhibitors, amide and urea derivatives, were designed, synthesized, and evaluated. The amide derivatives of compound 6d, with 4-NO2 in the benzene ring, showed the most potent inhibition of E. coli PDHc-E1. T... | ['Amides', 'Binding Sites', 'Catalytic Domain', 'Drug Design', 'Enzyme Inhibitors', 'Escherichia coli', 'Hydrogen Bonding', 'Models, Molecular', 'Molecular Docking Simulation', 'Molecular Structure', 'Pyruvate Dehydrogenase (Lipoamide)', 'Urea'] | 24,800,939 | [['D02.065'], ['G02.111.570.120'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D27.505.519.389'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G02.282'], ['E05.599.595'], ['E05.599.595.249', 'L01.224.160.249'], ['G02.111.5... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
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