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Possible role of mtDNA depletion and respiratory chain defects in aristolochic acid I-induced acute nephrotoxicity. | This report describes an investigation of the pathological mechanism of acute renal failure caused by toxic tubular necrosis after treatment with aristolochic acid I (AAI) in Sprague-Dawley (SD) rats. The rats were gavaged with AAI at 0, 5, 20, or 80 mg/kg/day for 7 days. The pathologic examination of the kidneys showe... | ['Acute Kidney Injury', 'Animals', 'Aristolochic Acids', 'Blood Urea Nitrogen', 'Creatinine', 'DNA, Mitochondrial', 'Dose-Response Relationship, Drug', 'Electron Transport Complex I', 'Electron Transport Complex II', 'Energy Metabolism', 'Kidney Tubular Necrosis, Acute', 'Mitochondrial Diseases', 'Rats', 'Rats, Sprague... | 22,820,421 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['B01.050'], ['D02.455.426.559.847.723.089', 'D02.640.139', 'D04.615.723.089'], ['E01.370.225.124.100.115', 'E01.370.390.400.100', 'E05.200.124.100.115'], ['D03.383.129.308.207'], ['D13.444.308.283.225'], ['G07.690.773.875', 'G07.690.936.500'], ['D05.500.562.249', 'D... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population: the Wakayama Spine Study. | OBJECTIVE: Many asymptomatic individuals have radiographic lumbar spinal stenosis (LSS), but the prevalence of symptoms among individuals with radiographic LSS has not yet been established. The purpose of this study was to clarify the association between radiographic LSS and clinical symptoms in the general population.... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cross-Sectional Studies', 'Female', 'Humans', 'Japan', 'Logistic Models', 'Lumbar Vertebrae', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Prevalence', 'Spinal Stenosis'] | 23,473,979 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Surveying Lactation Professionals Regarding Marijuana Use and Breastfeeding. | BACKGROUND: Breastfeeding is associated with substantial benefits for both the child and mother. Most guidelines state that women who use illicit drugs should not breastfeed. Although this recommendation has traditionally included marijuana, this drug's changing legal status and the limited scientific research regardin... | ['Adult', 'Breast Feeding', 'Cannabis', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Infant Nutritional Physiological Phenomena', 'Infant, Newborn', 'Lactation', 'Marijuana Smoking', 'Milk, Human', 'Mothers', 'New England', 'Pregnancy'] | 26,252,053 | [['M01.060.116'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['B01.650.940.800.575.912.250.859.937.055.500'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.203.650.220.500'], ['M01.060.703.520'], ['G08.686.523', 'G08.686.702... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Gene flow pattern among Aedes aegypti populations in Mexico. | Patterns of gene flow vary greatly among Aedes aegypti populations throughout Mexico. The populations are panmictic along the Pacific coast, isolated by distance in northeast Mexico, and exhibit moderate gene flow across the Yucatan peninsula. Nine Ae. aegypti collections from 6 cities in Oaxaca, Mexico, were taken to ... | ['Aedes', 'Animals', 'Cluster Analysis', 'DNA, Mitochondrial', 'Gene Flow', 'Genetic Variation', 'Geography', 'Haplotypes', 'Latin America', 'Mexico', 'Phylogeny'] | 23,687,850 | [['B01.050.500.131.617.720.500.500.750.712.500.875.100'], ['B01.050'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['D13.444.308.283.225'], ['G05.330.159'], ['G05.365'], ['H01.277.500'], ['G05.380.360'], ['Z01.107.424'], ['Z01.107.567.589'], ['G05.697', 'G16.075.605', 'L01.100.697']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Keratocystic odontogenic tumors: predictive factors of recurrence by Ki-67 and AgNOR labelling. | PURPOSE: The purpose of the present study was to investigate the possible role of Ki-67 and argyrophilic nucleolar organizing regions (AgNOR) between the recurrent and nonrecurrent keratocystic odontogenic tumors (KCOTs). Another aim was to compare the correlation between these two markers.MATERIALS AND METHODS: 22 KCO... | ['Adult', 'Aged', 'Female', 'Humans', 'Ki-67 Antigen', 'Male', 'Middle Aged', 'Nucleolus Organizer Region', 'Odontogenic Cysts', 'Odontogenic Tumors', 'Retrospective Studies', 'Young Adult'] | 22,639,545 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.660.625.500', 'D23.050.290.500', 'D23.101.140.400'], ['M01.060.116.630'], ['A11.284.430.106.279.345.190.160.650', 'G05.360.160.650', 'G05.360.340.024.380.875'], ['C04.182.089.530.690', 'C05.500.470.690', 'C07.320.450.670']... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mandibular thickness measurements in young dentate adults. | OBJECTIVE: To measure thicknesses in clinical landmark areas of the dentate mandibles of young men and women.DESIGN: Using standard radiologic software, we obtained mean (SD) thickness measurements at the inferior or posterior borders of the mandible at the following 7 surgically useful sites: (1) the symphysis, (2) a ... | ['Adolescent', 'Adult', 'Age Factors', 'Cohort Studies', 'Dentition', 'Female', 'Hospitals, University', 'Humans', 'Male', 'Mandible', 'Reference Values', 'Tomography, X-Ray Computed', 'Young Adult'] | 19,770,426 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['A03.556.500.379', 'A14.549.167'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', '... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The difference between activity when in bed and out of bed. II. Subjects on 27-hour "days". | Nine healthy subjects have been studied while exposed to the normal alternation of light and dark, but with their sleep and activity pattern adjusted to a 27-h "day" for 17 imposed "days." Rectal temperature showed clearly the competing influences of 27-h and 24-h components, and these were separated by the method of "... | ['Bed Rest', 'Body Temperature', 'Circadian Rhythm', 'Darkness', 'Humans', 'Light', 'Movement', 'Sleep', 'Time', 'Wakefulness'] | 8,874,981 | [['E02.075'], ['E01.370.600.875.374', 'G07.110'], ['G07.180.562.190'], ['G01.590.540.233'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G07.568', 'G11.427.410'], ['F02.830.855', 'G11.561.803'], ['G01.910'], ['F02.830.104.821', 'G11.561... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of lymphatic invasion in the prognosis of patients with clinical node-negative and pathologic node-positive lung adenocarcinoma. | OBJECTIVE: Some patients with clinical T1 N0 M0 lung adenocarcinoma have pathologic lymph node metastasis. However, neither the precise prognosis nor the factors predictive of the prognosis of such patients have yet been identified.METHODS: Our study included 609 patients with clinical T1 N0 M0 lung adenocarcinoma; 568... | ['Adenocarcinoma', 'Adenocarcinoma of Lung', 'Aged', 'Chi-Square Distribution', 'Disease-Free Survival', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Lung Neoplasms', 'Lymph Node Excision', 'Lymph Nodes', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Invasiveness', 'Neoplasm Recurre... | 24,507,979 | [['C04.557.470.200.025'], ['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['M01.060.116.100'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.3... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The in-hospital burden of hidradenitis suppurativa in patients with inflammatory bowel disease: a decade nationwide analysis from 2004 to 2014. | BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that significantly affects the patient's quality of life. Multiple studies have shown a strong association between HS and inflammatory bowel disease (IBD). Our primary goal was to explore the in-hospital burden of HS on patients with IBD. Our s... | ['Adult', 'Age Factors', 'Cohort Studies', 'Comorbidity', 'Cost of Illness', 'Databases, Factual', 'Female', 'Hidradenitis Suppurativa', 'Hospital Costs', 'Hospital Mortality', 'Hospitalization', 'Humans', 'Incidence', 'Inflammatory Bowel Diseases', 'Inpatients', 'Linear Models', 'Logistic Models', 'Male', 'Middle Aged... | 29,431,201 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N05.715.350.225', 'N06.850.490.687'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Fecal levels of short-chain fatty acids and bile acids as determinants of colonic mucosal cell proliferation in humans. | We studied the correlation between fecal levels of short-chain fatty acids (SCFA), bile acids (BA), and colonic mucosal proliferation in humans on a free diet. Subjects [n = 43: 27 men and 16 women; 61 +/- 7 and 59 +/- 6 (SE) yr old, respectively] were outpatients who previously underwent resection of at least two spor... | ['Aged', 'Bile Acids and Salts', 'Cell Division', 'Colon', 'Colonic Neoplasms', 'Diet', 'Fatty Acids', 'Feces', 'Female', 'Humans', 'Intestinal Mucosa', 'Male', 'Middle Aged'] | 12,416,258 | [['M01.060.116.100'], ['D04.210.500.105'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['G07.203.650.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Effect of clozapine and risperidone on serum cytokine levels in patients with first-episode paranoid schizophrenia]. | OBJECTIVE: To study the effects of clozapine and risperidone on serum cytokine levels in patients with first-episode paranoid schizophrenia, and explore the role of the cytokines in the psychopathological basis of the illness.METHOD: Fifty-eight patients with first-episode paranoid schizophrenia were treated with eithe... | ['Adolescent', 'Adult', 'Antipsychotic Agents', 'Clozapine', 'Cytokines', 'Female', 'Humans', 'Interleukin-18', 'Interleukin-2', 'Interleukin-6', 'Male', 'Risperidone', 'Schizophrenia, Paranoid', 'Tumor Necrosis Factor-alpha'] | 15,567,770 | [['M01.060.057'], ['M01.060.116'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['D03.633.300.240.220'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.518', 'D12.776.467.374.465.518', 'D23.529.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Insulin inhibits growth hormone signaling via the growth hormone receptor/JAK2/STAT5B pathway. | Insulin is important for maintaining the responsiveness of the liver to growth hormone (GH). Insulin deficiency results in a decrease in liver GH receptor (GHR) expression, which can be reversed by insulin administration. In osteoblasts, continuous insulin treatment decreases the fraction of cellular GHR localized to t... | ['Animals', 'DNA-Binding Proteins', 'Diabetes Mellitus, Type 2', 'Growth Hormone', 'Hyperinsulinism', 'Insulin', 'Iodine Radioisotopes', 'Janus Kinase 2', 'Milk Proteins', 'Obesity', 'Phosphorylation', 'Protein-Tyrosine Kinases', 'Proto-Oncogene Proteins', 'Radioligand Assay', 'Rats', 'Receptors, Somatotropin', 'STAT5 ... | 10,224,108 | [['B01.050'], ['D12.776.260'], ['C18.452.394.750.149', 'C19.246.300'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['C18.452.394.968'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['D08.811.913.696.620.682.725.124.200', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[The pathogenetic basis for using antiestrogens in treating patients with hyperplastic processes of the endometrium in the postmenopause]. | Estradiol and progesterone cytosol receptors, tamoxifen relative binding capacity in endometrial tissue samples, serum estradiol and progesterone levels were studied in 60 postmenopausal patients with hyperplastic processes in the endometrium. Estradiol and progesterone receptor levels were increased in glandular cysti... | ['Aged', 'Aged, 80 and over', 'Combined Modality Therapy', 'Cytosol', 'Endometrial Hyperplasia', 'Endometrium', 'Estradiol', 'Estrogen Antagonists', 'Female', 'Humans', 'Middle Aged', 'Postmenopause', 'Progesterone', 'Receptors, Estradiol', 'Receptors, Progesterone'] | 8,311,159 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.186'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['C13.351.500.852.228'], ['A05.360.319.679.490'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D06.347.295', 'D27.505.696.399.450.327'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Rectal application of a highly osmolar personal lubricant in a macaque model induces acute cytotoxicity but does not increase risk of SHIV infection. | BACKGROUND: Personal lubricant use is common during anal intercourse. Some water-based products with high osmolality and low pH can damage genital and rectal tissues, and the polymer polyquaternium 15 (PQ15) can enhance HIV replication in vitro. This has raised concerns that lubricants with such properties may increase... | ['Animals', 'Epithelium', 'Female', 'Hemorrhage', 'Hydrogen-Ion Concentration', 'Lubricants', 'Macaca fascicularis', 'Microbiota', 'Osmolar Concentration', 'Rectum', 'Risk', 'Simian Acquired Immunodeficiency Syndrome', 'Simian Immunodeficiency Virus', 'Time Factors', 'Viremia', 'Virus Shedding', 'Water'] | 25,853,710 | [['B01.050'], ['A10.272'], ['C23.550.414'], ['G02.300'], ['D27.720.556'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['G06.591', 'G16.500.275.157.049.100.500', 'N06.230.124.049.100.500'], ['G02.640'], ['A03.556.124.526.767', 'A03.556.249.249.767'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.6... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Purification and partial characterization of phosphatidylinositol-4-phosphate kinase from rat liver plasma membranes. Further evidence for a stimulatory G-protein. | Phosphatidylinositol 4-phosphate (PIP) kinase (E.C. 2.7.1.68) has been purified about 1200-fold from rat liver plasma membranes, taking advantage of affinity chromatography on quercetin-Sepharose as a novel step. The purified PIP kinase showed no contamination by the following enzyme activities: phosphatidylinositol (P... | ['Cell Membrane', 'Chromatography', 'Chromatography, Affinity', 'Chromatography, Ion Exchange', 'Durapatite', 'GTP-Binding Proteins', 'Hydroxyapatites', 'Kinetics', 'Liver', 'Phosphotransferases', 'Phosphotransferases (Alcohol Group Acceptor)'] | 2,157,497 | [['A11.284.149'], ['E05.196.181'], ['E05.196.181.400.170'], ['E05.196.181.400.383'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['D01.029.260.700.675.374.075.025.300', 'D01.146.360.... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 Iodine seed. | INTRODUCTION: The use of neo-adjuvant chemotherapy has increased in the treatment of loco-regionally advanced primarily operable breast cancer. As a result of improved neo-adjuvant chemotherapy regimes the number of clinical as well as radiological responses have increased. In case of a complete response it is difficul... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Breast Neoplasms', 'Combined Modality Therapy', 'Female', 'Humans', 'Iodine Radioisotopes', 'Mastectomy, Segmental', 'Middle Aged', 'Neoadjuvant Therapy', 'Neoplasm, Residual', 'Radioimmunodetection', 'Radiopharmaceuticals'] | 19,883,989 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.180', 'C17.800.090.500'], ['E02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['E04.466.701'], ['M01.060.116.630'], ['E02.186.450'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Opposing role of Notch1 and Notch2 in a Kras(G12D)-driven murine non-small cell lung cancer model. | Lung cancer is the leading cause of cancer-related deaths worldwide. Recently, we have shown that Notch1 inhibition resulted in substantial cell death of non-small cell lung cancer (NSCLC) cells in vitro. New compounds targeting Notch signal transduction have been developed and are now being tested in clinical trials. ... | ['Animals', 'Basic Helix-Loop-Helix Transcription Factors', 'Carcinoma, Non-Small-Cell Lung', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'Disease Models, Animal', 'Dual Specificity Phosphatase 1', 'Gene Expression Regulation, Neoplastic', 'Homeodomain Proteins', 'Humans', 'Mice', 'Proto-Oncogene Proteins ... | 24,509,876 | [['B01.050'], ['D12.776.260.103', 'D12.776.930.125'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D08.811.277.352.650.587.200', 'D08.811.277.352... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of trandolapril on cardiac angiotensin I converting enzyme activity in rats with chronic heart failure following myocardial infarction. | The effects of long-term treatment with a novel angiotensin I converting enzyme (ACE) inhibitor, trandolapril, on ACE activity and cardiac function in rats with chronic heart failure (CHF) were examined and compared with those of captopril and enalapril. Left coronary artery ligation of rats resulted in decreases in me... | ['Angiotensin-Converting Enzyme Inhibitors', 'Animals', 'Cardiac Output', 'Cardiac Output, Low', 'Hemodynamics', 'Indoles', 'Male', 'Myocardial Infarction', 'Myocardium', 'Peptidyl-Dipeptidase A', 'Rats', 'Rats, Wistar'] | 7,474,361 | [['D27.505.519.389.745.085'], ['B01.050'], ['E01.370.370.380.150', 'G09.330.380.124'], ['C14.280.148', 'C23.888.192'], ['G09.330.380'], ['D03.633.100.473'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D08.811.277.656.350.350.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Asymptomatic carotid stenosis: which preoperative diagnosis is necessary and adequate?]. | Operative correction of asymptomatic ICA stenosis requires only CCT and intraarterial DSA of all the common noninvasive procedures. Multiple vessel disease, however, must also be examined by quantitative cerebral blood flow measurements to determine the autoregulation reserve capacity; this can be done by transcranial ... | ['Angiography, Digital Subtraction', 'Brain Ischemia', 'Carotid Stenosis', 'Cerebral Angiography', 'Diagnostic Imaging', 'Echoencephalography', 'Humans', 'Tomography, Emission-Computed, Single-Photon', 'Tomography, X-Ray Computed'] | 1,983,605 | [['E01.370.350.600.350.700.060', 'E01.370.350.700.060.060', 'E01.370.350.700.700.060', 'E01.370.350.760.060', 'E01.370.370.050.060'], ['C10.228.140.300.150', 'C14.907.253.092'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vivo cholesteryl ester selective uptake of mildly and standardly oxidized LDL occurs by both parenchymal and nonparenchymal mouse hepatic cells but SR-BI is only responsible for standardly oxidized LDL selective uptake by nonparenchymal cells. | In blood circulation, low density lipoproteins (LDL) can undergo modification, such as oxidation, and become key factors in the development of atherosclerosis. Although the liver is the major organ involved in the elimination of oxidized LDL (oxLDL), the identity of the receptor(s) involved remains to be defined. Our w... | ['Animals', 'Cholesterol Esters', 'Cholesterol, LDL', 'Hepatocytes', 'Lipoproteins, LDL', 'Mice', 'Mice, Inbred Strains', 'Mice, Knockout', 'Oxidation-Reduction', 'Scavenger Receptors, Class B'] | 16,427,800 | [['B01.050'], ['D04.210.500.247.222.284.200', 'D04.210.500.247.808.197.200', 'D10.570.938.208.250'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['A11.436.348'], ['D10.532.515', 'D12.776.521.550'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Self-mutilation in antisocial personality (disorder). | In the present study, attempts were made to clarify the characteristics and the background information of persons with antisocial personality (disorder) who had resorted to slashings. These were compared with controls with a similar personality disorder who had not resorted to slashings. It appeared that the former had... | ['Adult', 'Age Factors', 'Antisocial Personality Disorder', 'Humans', 'Male', 'Prisoners', 'Self Mutilation', 'Sensory Deprivation', 'Social Environment', 'Time Factors'] | 1,007,938 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['F03.675.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.729'], ['C26.780', 'F01.145.126.980.750'], ['F02.463.593.696'], ['I01.880.853.500'], ['G01.910.857']] | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Application of a continuously stirred tank bioreactor (CSTR) for bioremediation of hydrocarbon-rich industrial wastewater effluents. | A continuously stirred tank bioreactor (CSTR) was used to optimize feasible and reliable bioprocess system in order to treat hydrocarbon-rich industrial wastewaters. A successful bioremediation was developed by an efficient acclimatized microbial consortium. After an experimental period of 225 days, the process was sho... | ['Bacteria', 'Biodegradation, Environmental', 'Bioreactors', 'Hydrocarbons', 'Industrial Waste', 'Microbial Consortia', 'Petroleum', 'Toxicity Tests', 'Waste Disposal, Fluid', 'Water Purification'] | 21,419,572 | [['B03'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['E07.115', 'J01.897.120.115'], ['D02.455'], ['D20.944.420', 'N06.850.460.710.420'], ['G06.591.750', 'G16.500.275.157.049.100.500.750', 'N06.230.124.049.100.500.500'], ['D20.345.630', 'N06.230.132.258.630'], ['E05.940'], ['N06.850.780.200.800.800.890', 'N06.850.... | ['Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Nuclear fragmentation in colon carcinoma cells. | The nuclei of the epithelial cells of well differentiated adenocarcinoma of the large intestine show characteristic appendages, the nucleotesimals, connected with the main nucleus by lamellar bridges. We interpret this phenomenon as being the result of a hitherto unknown type of amitosis that permits rapid cancer growt... | ['Adenocarcinoma', 'Cell Nucleus', 'Chromatin', 'Colonic Neoplasms', 'Humans', 'Nuclear Envelope'] | 730,149 | [['C04.557.470.200.025'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['B01.050.150.900.649.... | ['Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of the BioPlex 2200 syphilis system as a first-line method of reverse-sequence screening for syphilis diagnosis. | Despite recent technological advances, the diagnosis of syphilis remains a challenging enterprise. Actually, most high-volume laboratories have adopted the "reverse algorithm" due several factors, including the potential to automate testing. Recently, immunoassays processed on random-access systems have been proposed a... | ['Aged', 'Aged, 80 and over', 'Antibodies, Bacterial', 'Automation, Laboratory', 'Clinical Laboratory Techniques', 'Female', 'Humans', 'Immunoglobulin G', 'Immunoglobulin M', 'Male', 'Mass Screening', 'Pregnancy', 'Retrospective Studies', 'Sensitivity and Specificity', 'Syphilis', 'Treponema pallidum'] | 23,697,575 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['E05.064', 'J01.897.104.416'], ['E01.370.225', 'E05.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Point mutations of the connexin32 (GJB1) gene in X-linked dominant Charcot-Marie-Tooth neuropathy. | Ten families with X-linked dominant CMT neuropathy (CMTX1) were screened for point mutations of the connexin32 (Cx32, GJB1) gene. Two families showed missense mutations, respectively an A-->G transition at amino acid 102 (glutamate to glycine) and a C-->T transition at amino acid 142 (arginine to tryptophan). Three fam... | ['Amino Acid Sequence', 'Base Sequence', 'Charcot-Marie-Tooth Disease', 'Connexins', 'Female', 'Genes', 'Genes, Dominant', 'Humans', 'Male', 'Molecular Sequence Data', 'Pedigree', 'Point Mutation', 'X Chromosome'] | 8,004,109 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C10.500.300.200', 'C10.574.500.495.200', 'C10.668.829.800.300.200', 'C16.131.666.300.200', 'C16.320.400.375.200'], ['D12.776.543.585.250'], ['G05.360.340.024.340'], ['G05.360.340.024.340.240', 'G05.420.320'], ['B01... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Determination of specific activity of (226)Ra, (232)Th and (40)K for assessment of radiation hazards from Turkish pumice samples. | The specific activity of (226)Ra, (232)Th and (40)K in 52 Turkish pumice samples collected from 11 geographical areas located in Central Anatolia, Eastern Anatolia, Mediterranean and Aegean regions was determined by gamma-ray spectrometry with a high-purity germanium (HPGe) detector. The specific activity of (226)Ra, (... | ['Potassium Radioisotopes', 'Radiometry', 'Radium', 'Silicates', 'Thorium', 'Turkey'] | 17,913,315 | [['D01.268.549.550.500.700', 'D01.268.557.575.500.700', 'D01.496.705.700', 'D01.496.749.690', 'D01.552.528.652.500.700', 'D01.552.547.650.500.700'], ['E05.799'], ['D01.268.271.770', 'D01.268.552.775', 'D01.268.556.775', 'D01.496.749.305.770', 'D01.552.539.745', 'D01.552.544.775'], ['D01.578.725', 'D01.837.725.700.760']... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Desethylamiodarone prolongation of cardiac repolarization is dependent on gene expression: a novel antiarrhythmic mechanism. | Desethylamiodarone (DEA) is the major metabolite of amiodarone and has similar electrophysiologic effects with prolongation of the repolarization that is reversed by thyroid hormone (T3). Some of the electrophysiologic effects are probably due to antagonism of T3 at the receptor level. Such effects of T3 are mediated b... | ['Action Potentials', 'Amiodarone', 'Animals', 'Blotting, Western', 'Cycloheximide', 'Dactinomycin', 'Female', 'Gene Expression', 'Guinea Pigs', 'Heart', 'Homeostasis', 'Male', 'Protein Synthesis Inhibitors', 'Triiodothyronine'] | 9,781,936 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['D03.633.100.127.075'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D03.383.621.808.240'], ['D03.633.300.200', 'D04.345.566.252', 'D12.644.641.252'], ['G05.297'], ['B01.050.150.900.649.313.99... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effectiveness of Basic Life Support Training for Middle School Students. | Bystander cardiopulmonary resuscitation improves survival after out-of-hospital cardiac arrest. This study aimed to assess the effectiveness of a basic life support (BLS) educational course given to 110 middle school children, using a pretest posttest design. In the pretest, students were asked to demonstrate BLS on a ... | ['Adolescent', 'Cardiopulmonary Resuscitation', 'Female', 'Health Education', 'Heart Arrest', 'Humans', 'Male', 'Manikins', 'Students'] | 29,361,872 | [['M01.060.057'], ['E02.365.647.110'], ['I02.233.332', 'N02.421.726.407'], ['C14.280.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.280.500.545.129.400', 'L01.178.820.090.545.129.400'], ['M01.848']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
A microcomputed tomography evaluation of the shaping ability of three thermally-treated nickel-titanium rotary file systems in curved canals. | OBJECTIVE: To evaluate the shaping ability of three thermally-treated rotary nickel-titanium (NiTi) systems including ProTaper Next (PTN), HyFlex™ CM (HFCM) and HyFlex™ EDM (HFEDM) during root canal preparation in simulated root canals.METHODS: A total of 45 simulated root canals were divided into three groups ( n = 15... | ['Dental Pulp Cavity', 'Equipment Design', 'Humans', 'Models, Anatomic', 'Nickel', 'Resins, Synthetic', 'Root Canal Preparation', 'Titanium', 'X-Ray Microtomography'] | 30,282,507 | [['A14.549.167.900.265'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.280.500.545.129', 'L01.178.820.090.545.129'], ['D01.268.556.607', 'D01.268.956.625', 'D01.552.544.607'], ['D05.750.716.822', 'D25.339.816', 'D25.720.716.822', 'J01.637.051.339.816', 'J01.637.051.720.716.822'], ['E06.397.77... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Attachment pili from enterotoxigenic Escherichia coli pathogenic for humans. | Pili from enterotoxigenic Escherichia coli pathogenic for humans have been isolated by adsorption to the surface of erythrocytes followed by thermal elution. The pili are composed of two protein subunits with molecular weights of 13,100 and 12,500 as determined by sodium dodecyl sulfate-gel electrophoresis. These pili ... | ['Bacterial Proteins', 'Cheek', 'Enterotoxins', 'Erythrocytes', 'Escherichia coli', 'Fimbriae, Bacterial', 'Humans', 'Immunoglobulin G', 'Mouth Mucosa', 'Peptides'] | 40,882 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hsp90 facilitates acquired drug resistance of tumor cells through cholesterol modulation however independent of tumor progression. | Acquired multidrug resistance of cancer cells challenges the chemotherapeutic interventions. To understand the role of molecular chaperone, Hsp90 in drug adapted tumor cells, we have used in vitro drug adapted epidermoid tumor cells as a model system. We found that chemotherapeutic drug adaptation of tumor cells is med... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Angiogenesis Inducing Agents', 'Animals', 'Antineoplastic Agents', 'Apoptosis', 'Benzoquinones', 'Cell Line, Tumor', 'Cholesterol', 'Disease Progression', 'Drug Resistance, Multiple', 'Drug Resistance, Neoplasm', 'Gene Knockdown Techniques', 'HSP90 Heat-Shock... | 32,343,987 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['D27.505.696.377.077.077'], ['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['D02.806.250'], ['A11.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Time-responsive osteogenic niche of stem cells: A sequentially triggered, dual-peptide loaded, alginate hybrid system for promoting cell activity and osteo-differentiation. | The efficacy of stem cell-based bone tissue engineering has been hampered by cell death and limited fate control. A smart cell culture system with the capability of sequentially delivering multiple factors in specific growth stages, like the mechanism of the natural extracellular matrix modulating tissue formation, is ... | ['Alginic Acid', 'Animals', 'Bone Morphogenetic Protein 7', 'Cell Adhesion', 'Cell Differentiation', 'Cell Proliferation', 'Cell Survival', 'Drug Carriers', 'Female', 'Glycine', 'Humans', 'Hydrogels', 'Mesenchymal Stem Cells', 'Mice, Inbred BALB C', 'Nanoparticles', 'Oligopeptides', 'Osteogenesis', 'Particle Size', 'Pe... | 29,452,946 | [['D02.241.081.844.915.162.249.500', 'D02.241.081.844.915.400.250', 'D02.241.152.811.162.500.500', 'D02.241.152.811.400.250', 'D02.241.511.902.915.162.500.500', 'D02.241.511.902.915.400.250', 'D09.698.068.500', 'D09.811.922.162.500.500', 'D09.811.922.400.250'], ['B01.050'], ['D12.644.276.954.200.700', 'D12.776.467.942.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Protective effect of Hemidesmus indicus L. R. Br. against bromobenzene-induced mitochondrial dysfunction in rat kidney. | Hemidesmus indicus (HI) is used in ancient Indian traditional herbal medicine to treat hepatic and renal disorders. The present study was designed to investigate the protective effect of HI aqueous extract against bromobenzene induced mitochondrial dysfunction in rat kidneys. Rats were administered bromobenzene with or... | ['Animals', 'Antioxidants', 'Bromobenzenes', 'Cell Respiration', 'Enzymes', 'Hemidesmus', 'Kidney', 'Kidney Diseases', 'Lipid Peroxidation', 'Male', 'Mitochondria', 'Oxidative Stress', 'Phytotherapy', 'Plant Extracts', 'Protein Carbonylation', 'Rats', 'Rats, Wistar', 'Vitamin E'] | 22,745,071 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D02.455.426.559.389.220', 'D02.455.526.368.150'], ['G03.197', 'G04.270'], ['D08.811'], ['B01.650.940.800.575.912.250.456.500.341'], ['A05.810.453'], ['C12.777.419', 'C13.351.968.419'], ['G02.111.515', 'G03.295.531.587'], ['A11.284.430.214.19... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Psychometric Properties of the Obstacles to Return-to-Work Questionnaire in a Brazilian context. | Purpose To evaluate the psychometric properties of the Obstacles to Return-to-Work Questionnaire (ORTWQ) among Brazilian workers on sick-leave due to musculoskeletal disorders. Methods Confirmatory factor analysis was conducted to evaluate the factor structure validity of the ORTWQ. Model fit indices and salience of fa... | ['Adult', 'Brazil', 'Depression', 'Disability Evaluation', 'Factor Analysis, Statistical', 'Female', 'Humans', 'Male', 'Middle Aged', 'Musculoskeletal Diseases', 'Pain', 'Psychometrics', 'Reproducibility of Results', 'Return to Work', 'Statistics, Nonparametric', 'Surveys and Questionnaires'] | 27,854,043 | [['M01.060.116'], ['Z01.107.757.176'], ['F01.145.126.350'], ['E01.370.400'], ['E05.318.740.400', 'N05.715.360.750.350', 'N06.850.520.830.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['F04.711.780'], ['E05.318.370.725', '... | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Allometric versus consensus guideline dosing in achieving target vancomycin trough concentrations. | PURPOSE: Results of a study comparing the performance of allometric versus consensus guideline-recommended vancomycin dosing in achieving initial trough concentrations within the desired range are reported.METHODS: A retrospective study was conducted to compare selected outcomes with 2 vancomycin dosing methods: (1) do... | ['Adult', 'Aged', 'Anti-Bacterial Agents', 'Body Size', 'Body Weight', 'Consensus', 'Dose-Response Relationship, Drug', 'Female', 'Hospitalization', 'Humans', 'Infusions, Intravenous', 'Male', 'Middle Aged', 'Obesity', 'Practice Guidelines as Topic', 'Retrospective Studies', 'Vancomycin'] | 28,522,643 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['F01.829.316.068', 'F02.463.785.373.433'], ['G07.690... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A coherent graph-based semantic clustering and summarization approach for biomedical literature and a new summarization evaluation method. | BACKGROUND: A huge amount of biomedical textual information has been produced and collected in MEDLINE for decades. In order to easily utilize biomedical information in the free text, document clustering and text summarization together are used as a solution for text information overload problem. In this paper, we intr... | ['Algorithms', 'Artificial Intelligence', 'Cluster Analysis', 'Database Management Systems', 'Information Storage and Retrieval', 'MEDLINE', 'Natural Language Processing', 'Pattern Recognition, Automated', 'Periodicals as Topic', 'Semantics', 'User-Computer Interface'] | 18,047,705 | [['G17.035', 'L01.224.050'], ['G17.035.250', 'L01.224.050.375'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['L01.224.068', 'L01.224.900.280', 'N04.452.515.110'], ['L01.313.500.750.280', 'L01.470'], ['L01.313.500.750.280.710.500', 'L01.313.500.750.280.750.500', 'L01.313.500.750.300.188.300.650.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
R1 correction in amide proton transfer imaging: indication of the influence of transcytolemmal water exchange on CEST measurements. | Amide proton transfer (APT) imaging may potentially detect mobile proteins/peptides non-invasively in vivo, but its specificity may be reduced by contamination from other confounding effects such as asymmetry of non-specific magnetization transfer (MT) effects and spin-lattice relaxation with rate R1 (=1/T1). Previousl... | ['Amides', 'Animals', 'Artifacts', 'Biological Transport, Active', 'Body Water', 'Brain Neoplasms', 'Cell Line, Tumor', 'Extracellular Fluid', 'Humans', 'Intracellular Fluid', 'Magnetic Resonance Spectroscopy', 'Molecular Imaging', 'Protons', 'Rats', 'Rats, Inbred F344', 'Reproducibility of Results', 'Sensitivity and S... | 26,466,161 | [['D02.065'], ['B01.050'], ['E05.047'], ['G03.143.310'], ['A12.207.200'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.295.260', 'A12.207.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.429', 'A11.284.835.450', 'A12.207.515'], ['E... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nonalcoholic fatty liver disease and age are strong indicators for atherosclerosis in morbid obesity. | OBJECTIVE: Whether nonalcoholic fatty liver disease (NAFLD) can predict atherosclerosis in obese patients remains unclear. The aim of our study was to investigate the usefulness of NAFLD and other cardiometabolic parameters in predicting subclinical atherosclerosis in obese patients.DESIGN, PATIENTS AND MEASUREMENTS: W... | ['Adult', 'Age Factors', 'Anthropometry', 'Atherosclerosis', 'Biopsy', 'Body Mass Index', 'Carotid Intima-Media Thickness', 'Fatty Liver', 'Female', 'Humans', 'Liver', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Non-alcoholic Fatty Liver Disease', 'Obesity', 'Obesity, Morbid', 'Prevalence', 'Risk', 'Sensitivity an... | 25,510,350 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['C14.907.137.126.307'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.370.600.115.100.125', 'E05.041.12... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Multiple-dose evaluation of intravenous hydromorphone pharmacokinetics in normal human subjects. | We measured the pharmacokinetics of hydromorphone in normal volunteers given three doses of the drug (10, 20, and 40 micrograms/kg) as intravenous 45-s injections on different days. Concentrations of hydromorphone in plasma from serial blood samples were measured by a high-performance liquid chromatography method speci... | ['Adult', 'Analysis of Variance', 'Chromatography, High Pressure Liquid', 'Half-Life', 'Humans', 'Hydromorphone', 'Injections, Intravenous', 'Male'] | 1,704,690 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.196.181.400.300'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.577.249.562.450', 'D03.605.497.607.500', 'D03.633.400.686.607.500', 'D04.615.723.795.576.450'], ['E02.319.267.082.750', 'E02.319.267.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of individual ultrasound microbubble dynamics with a light-scattering system. | Ultrasound microbubbles are contrast agents used for diagnostic ultrasound imaging and as carriers for noninvasive payload delivery. Understanding the acoustic properties of individual microbubble formulations is important for optimizing the ultrasound imaging parameters for improved image contrast and efficient payloa... | ['Contrast Media', 'Fourier Analysis', 'Light', 'Microbubbles', 'Nonlinear Dynamics', 'Scattering, Radiation', 'Ultrasonography'] | 21,721,823 | [['D27.505.259.500', 'D27.720.259'], ['E05.377', 'G17.226', 'L01.224.800.625'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E07.553'], ['E05.599.850', 'H01.548.675'], ['E05.196.822', 'G01.867'], ['E01.370.350.850']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Drain placement in thyroidectomy is associated with longer hospital stay without preventing hematoma. | OBJECTIVE: To analyze the effect of drain placement on postoperative hematoma formation and other associated outcomes post-thyroid surgery in a large national cohort.METHODS: This was a retrospective study that analyzed data from the 2016-2017 National Surgical Quality Improvement Program (NSQIP) public use files. Base... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Cohort Studies', 'Drainage', 'Female', 'Hematoma', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Postoperative Complications', 'Retrospective Studies', 'Thyroidectomy', 'United States', 'Young Adult'] | 31,508,818 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.309', 'E04.237'], ['C23.550.414.838'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Psychological homelessness and enculturative stress among US-deported Salvadorans: a preliminary study with a novel approach. | The purpose of this study was to examine the construct psychological homelessness-feelings of not belonging in one's home country-within the context of deported Salvadorans' enculturation to El Salvador. Participants (n = 66) who had been deported from the United States completed a set of questionnaires related to thei... | ['Acculturation', 'Adult', 'Aged', 'El Salvador', 'Emigrants and Immigrants', 'Female', 'Humans', 'Male', 'Middle Aged', 'Stress, Psychological', 'Surveys and Questionnaires', 'Undocumented Immigrants', 'United States', 'Young Adult'] | 24,639,053 | [['I01.076.201.450.050', 'I01.880.853.100.079'], ['M01.060.116'], ['M01.060.116.100'], ['Z01.107.169.339'], ['M01.189'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.145.126.990', 'F02.830.900'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['M01.189.500'], ['Z01.107... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The relationship between acute psychiatric symptoms, diagnosis, and short-term risk of violence. | OBJECTIVE: Previous research on violence and mental disorder has typically focused on the relationship between diagnosis and risk of violence or between symptoms within a particular diagnostic category and risk of violence. The authors' goal was to evaluate whether the pattern of symptoms associated with short-term ris... | ['Acute Disease', 'Aggression', 'Bipolar Disorder', 'Dangerous Behavior', 'Humans', 'Mental Disorders', 'Neurocognitive Disorders', 'Patient Admission', 'Psychiatric Status Rating Scales', 'Risk Factors', 'Schizophrenia', 'Schizophrenic Psychology', 'Violence'] | 8,168,791 | [['C23.550.291.125'], ['F01.145.126.125', 'F01.145.813.045'], ['F03.084.500'], ['F01.145.263', 'I01.880.735.223'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F03.615'], ['E02.760.400.600', 'N02.421.585.400.600'], ['F04.711.513.653'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.6... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Telomerase inhibition, telomere attrition and proliferation arrest of cancer cells induced by phosphorothioate ASO-NLS conjugates targeting hTERC and siRNAs targeting hTERT. | Telomerase activity has been regarded as a critical step in cellular immortalization and carcinogenesis and because of this, regulation of telomerase represents an attractive target for anti-tumor specific therapeutics. Recently, one avenue of cancer research focuses on antisense strategy to target the oncogenes or can... | ['Cell Cycle Checkpoints', 'Cell Proliferation', 'Enzyme Activation', 'Enzyme Inhibitors', 'HeLa Cells', 'Humans', 'Nuclear Localization Signals', 'Oligonucleotides, Antisense', 'Peptides', 'Phosphates', 'RNA, Messenger', 'RNA, Small Interfering', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'Telo... | 32,310,030 | [['G04.144.109'], ['G04.161.750', 'G07.345.249.410.750'], ['G02.111.263', 'G03.328'], ['D27.505.519.389'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.770.610', 'G02.111.570.060.670.610'], ['D13.150.480', 'D13.444.600.150.640', 'D13.695.578.4... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Drug interactions. II. Formation of nitrosamines from therapeutic drugs. Properties and kinetics of the formation of N-nitrosopropranolol from nitrite and the secondary amine propranolol hydrochloride. | In the presence of hydrochloric acid, nitrosamines may be generated from amines and nitrite. Most nitrosamines are carcinogens and many commonly used drugs contain potentially nitrosatable amine groups. Beta-adrenergic blockers, which have such amine groups, are widely prescribed and are often ingested for the lifetime... | ['Chemical Phenomena', 'Chemistry', 'Drug Interactions', 'Gas Chromatography-Mass Spectrometry', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Mass Spectrometry', 'Nitrites', 'Nitrosamines', 'Propranolol', 'Sodium Nitrite'] | 6,864,529 | [['G02'], ['H01.181'], ['G07.690.773.968'], ['E05.196.181.349.500', 'E05.196.566.500'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['E05.196.566'], ['D01.248.497.158.635', 'D01.625.600.600', 'D02.633'], ['D02.654.442'], ['D02.033.100.624.698.711', 'D02.033.755.624.698.711', 'D02.092.063.624.698.711', 'D02.455... | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Selective sparing of topographical memory. | The case of a 61 year old patient with Pick's disease involving predominantly the left temporal lobe, who has been studied over a 5 year period, is reported. She presented with a grave impairment of both verbal and non-verbal memory functions. Her non-verbal memory deficits included profound impairments on the recognit... | ['Brain', 'Dementia', 'Female', 'Humans', 'Memory Disorders', 'Mental Recall', 'Middle Aged', 'Semantics', 'Severity of Illness Index', 'Space Perception', 'Wechsler Scales'] | 9,854,968 | [['A08.186.211'], ['C10.228.140.380', 'F03.615.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.525', 'C23.888.592.604.529', 'F01.700.625'], ['F02.463.425.540.641'], ['M01.060.116.630'], ['L01.559.598.745'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308... | ['Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Analysis of PAEs in semen of infertile men. | OBJECTIVES: Phthalates are environmental chemicals with reproductive toxicity and estrogenic effects in animals. They are of increasing concern to human health.AIM: To determine whether phthalate levels in semen were associated with infertility.METHODS: Using semen samples from 107 infertile and 94 fertile men, the pre... | ['Adult', 'China', 'Chromatography, High Pressure Liquid', 'Environmental Exposure', 'Environmental Pollutants', 'Humans', 'Infertility, Male', 'Male', 'Middle Aged', 'Phthalic Acids', 'Semen', 'Semen Analysis', 'Young Adult'] | 25,384,258 | [['M01.060.116'], ['Z01.252.474.164'], ['E05.196.181.400.300'], ['N06.850.460.350'], ['D27.888.284'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['M01.060.116.630'], ['D02.241.223.805'], ['A12.200.732'], ['E01.370.225.992', 'E05.200.992'], ['M01.060.116.815']] | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Palatal patch-grafts in post areas of subperiosteal implants. | Transplantation of palatal patch-grafts before insertion of subperiosteal implants can be helpful in producing a better stress-bearing area for a prosthesis. Careful use of the technique assures adequate attached mucosa around the implant posts and reduces the possibility of infection and wound dehiscence. | ['Dental Implantation, Endosseous', 'Mandible', 'Mouth Mucosa', 'Palate', 'Periosteum'] | 1,068,264 | [['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['A10.615.550.599', 'A14.549.512'], ['A14.521.658', 'A14.549.617'], ['A10.165.265.746']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The positive inotropic effect of endothelin-1 is mediated by mitochondrial reactive oxygen species. | We have previously demonstrated the participation of reactive oxygen species (ROS) in the positive inotropic effect of a physiological concentration of Angiotensin II (Ang II, 1 nM). The objective of the present work was to evaluate the role and source of ROS generation in the positive inotropic effect produced by an e... | ['Angiotensin II', 'Animals', 'Cardiotonic Agents', 'Cats', 'Cells, Cultured', 'Dose-Response Relationship, Drug', 'Endothelin-1', 'Enzyme Inhibitors', 'Free Radical Scavengers', 'Glycine', 'Heart Ventricles', 'Mitochondria, Heart', 'Myocardial Contraction', 'Myocytes, Cardiac', 'NADPH Oxidases', 'Potassium Channel Blo... | 18,625,248 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['D27.505.954.411.222', 'D27.720.799.080'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['A11.251'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.644.276.40... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration. | The small GTPase Arf6 plays pivotal roles in a wide variety of cellular events such as endocytosis, exocytosis, and actin cytoskeleton reorganization. However, the physiological functions of Arf6 at the whole animal level have not yet been thoroughly understood. Here, we show that Arf6 regulates developmental and tumor... | ['ADP-Ribosylation Factors', 'Animals', 'Biomarkers', 'Cell Movement', 'Endothelial Cells', 'Fluorescent Antibody Technique', 'Immunohistochemistry', 'Integrin beta1', 'Lymphangiogenesis', 'Lymphatic Vessels', 'Mice', 'Mice, Knockout', 'Vascular Endothelial Growth Factor C', 'Wound Healing'] | 28,900,118 | [['D08.811.277.040.330.300.400.100', 'D12.644.360.525.100', 'D12.776.157.325.515.100', 'D12.776.476.525.100'], ['B01.050'], ['D23.101'], ['G04.198', 'G07.568.500.180'], ['A11.436.275'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Note on the detection of hemoglobin lepore in a Senegalaise (author's transl)]. | After reviewing briefly the characteristic features of hemoglobins Lepore, their distribution and their clinical symptoms, the authors report on a senegalese case. | ['Blood Protein Electrophoresis', 'Hemoglobins', 'Hemoglobins, Abnormal', 'Humans', 'Male', 'Senegal'] | 7,339,428 | [['E01.370.225.124.100.110', 'E05.196.401.076', 'E05.200.124.100.110', 'E05.301.300.049'], ['D12.776.124.400', 'D12.776.422.316.762'], ['D12.776.124.400.463', 'D12.776.422.316.762.426'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.058.290.190.710']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma. | FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. This phase I study assessed safety, tolerability, maximum tolerated do... | ['Aged', 'Aged, 80 and over', 'Antineoplastic Agents, Immunological', 'Biomarkers', 'Drug Monitoring', 'Drug Resistance, Neoplasm', 'Female', 'Follow-Up Studies', 'Humans', 'Immunoconjugates', 'Immunophenotyping', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Receptors, Fc', 'Recurrence', 'Retreatment', 'Treatment Outcom... | 30,718,503 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248.384'], ['D23.101'], ['E01.370.520.200'], ['G07.690.773.984.395'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.790.651.114.580', 'D12.776.377.715.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Conformational study of alanine and alpha-aminoisobutyric psi [NHCO]-retroamide peptide analogues. | The minimum-energy conformations of N,N'-dimethyl-2-methylmalondiamide (2mMA) and N,N'-dimethyl-2-dimethylmalondiamide (2dmMA) have been computed using the AM1 method. The results show that molecules tend to form an intramolecular six-membered ring hydrogen-bond system. The same trend is observed in crystals of malonam... | ['Alanine', 'Aminoisobutyric Acids', 'Methylmalonic Acid', 'Peptides', 'Protein Conformation', 'Structure-Activity Relationship', 'Thermodynamics'] | 8,005,748 | [['D12.125.042'], ['D02.241.081.114.968.249', 'D12.125.070.075', 'D12.125.190.055'], ['D02.241.081.337.540.500'], ['D12.644'], ['G02.111.570.820.709'], ['G02.111.830', 'G07.690.773.997'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pathological validation of supracricoid partial laryngectomy in laryngeal cancer. | OBJECTIVES: To validate pathologically whether supracricoid partial laryngectomy is an oncologically sound procedure in cases with invasion of the thyroid cartilage, paraglottic space, pre-epiglottic space, anterior commissure, or subglottis.DESIGN: A retrospective review of case notes was performed.SETTING: Patients t... | ['Aged', 'Carcinoma, Squamous Cell', 'Combined Modality Therapy', 'Cricoid Cartilage', 'Epiglottis', 'Female', 'Follow-Up Studies', 'Glottis', 'Humans', 'Laryngeal Neoplasms', 'Laryngectomy', 'Larynx', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Prognosis', 'Radiot... | 19,413,611 | [['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.186'], ['A02.165.257.625.211', 'A02.165.407.500.211', 'A04.329.591.211'], ['A02.165.257.625.411', 'A02.165.407.500.411', 'A04.329.591.411'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A04.329.36... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
To breathe or not to breathe: optimal strategies for finding prey in a dark, three-dimensional environment. | The use of sophisticated telemetry logging devices has revealed that short-finned pilot whales employ energetic sprints to chase down their deep-dwelling prey. These sprints are costly in terms of energy, and therefore oxygen, which is a valuable resource for an animal that has to hold its breath while hunting. This fi... | ['Animals', 'Environment', 'Predatory Behavior', 'Respiration', 'Telemetry', 'Whales, Pilot'] | 18,844,756 | [['B01.050'], ['G16.500.275', 'N06.230'], ['F01.145.113.111.600', 'F01.145.113.252.520'], ['G09.772.705'], ['E01.370.520.750', 'E05.925', 'L01.178.847.675'], ['B01.050.150.900.649.313.875.267.920']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
[Extracorporeal membrane oxygenation in the treatment of acute respiratory failure in full-term neonates]. | OBJECTIVE OF STUDY: Evaluation of success of extracorporeal membrane oxygenation, EMCO) in the treatment of acute respiratory failure in mature neonates.TYPE OF STUDY: Clinical pilot study of the EMCO centre.SETTING: Institute for the Care of Mother and Child, Prague.MATERIAL AND METHOD: In 12 consecutive patients with... | ['Acute Disease', 'Extracorporeal Membrane Oxygenation', 'Humans', 'Infant, Newborn', 'Pilot Projects', 'Respiratory Insufficiency'] | 11,394,233 | [['C23.550.291.125'], ['E02.880.301', 'E04.292.451'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['C08.618.846']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ill-health retirement among healthcare workers in the Southern Health Board of the Republic of Ireland. | AIM: To determine the incidence rates, trends and medical causes of ill-health retirement (IHR) among different occupational classes in the Southern Health Board (SHB).METHODS: The 14 702 permanent employees of the SHB were divided into six occupational classes based on socio-economic status and occupational demands. T... | ['Female', 'Health Behavior', 'Health Personnel', 'Humans', 'Ireland', 'Male', 'Middle Aged', 'Pensions', 'Retirement', 'Sex Distribution'] | 16,040,769 | [['F01.145.488'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.467', 'Z01.639.587'], ['M01.060.116.630'], ['N01.824.417.510'], ['I03.702'], ['I01.240.800', 'N01.224.803', 'N06.850.505.400.850']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Perceptual learning incepted by decoded fMRI neurofeedback without stimulus presentation. | It is controversial whether the adult primate early visual cortex is sufficiently plastic to cause visual perceptual learning (VPL). The controversy occurs partially because most VPL studies have examined correlations between behavioral and neural activity changes rather than cause-and-effect relationships. With an onl... | ['Adult', 'Analysis of Variance', 'Brain Mapping', 'Female', 'Humans', 'Learning', 'Magnetic Resonance Imaging', 'Male', 'Neurofeedback', 'Neuronal Plasticity', 'Size Perception', 'Visual Cortex', 'Visual Perception', 'Young Adult'] | 22,158,821 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['E01.370.350.825.500'], ['E02.190.525.123.500', 'F02.830.131.500', 'F04.75... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Distribution and epidemiological value of Rhipicephalus turanicus. Ecology of the species in the South-Mediterranean part of France (author's transl)]. | Following a study of potential vectors of the boutonneuse Fever in the lower Rh?ne valley, the authors summarize knowledge concerning Rh. turanicus (biogeography, hosts, seasonal dynamics). Using their own work, they emphasize its distribution and ecology in the French mediterranean region: as an exophile species, freq... | ['Animals', 'Ecology', 'France', 'Humans', 'Insect Vectors', 'Seasons', 'Ticks'] | 7,332,198 | [['B01.050'], ['H01.158.273.248', 'H01.277.249'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.335.188.100.500', 'N06.850.520.203.375.100.500'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['B01.050.500.131.166.132.832']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Structure-function relations of the thyrotropin receptor. | The thyrotropin (thyroid-stimulating hormone or TSH) receptor is an amphiphilic membrane component with a relative molecular mass of about 200,000 as judged by gel filtration and an isoelectric point close to pH 5. Analyses with chemical, enzymic and affinity probes indicate that the receptor is a glycoprotein containi... | ['Antibody Specificity', 'Autoantibodies', 'Graves Disease', 'Humans', 'Lymphocytes', 'Macromolecular Substances', 'Receptors, Cell Surface', 'Receptors, Thyrotropin', 'Structure-Activity Relationship', 'Thyroid Gland'] | 6,291,879 | [['G12.100'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['C11.675.349.500', 'C19.874.283.605', 'C19.874.397.370', 'C20.111.555'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['D05'], ['D1... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Computer graphics of apatite crystals]. | Hydroxyapatite was studied by computer graphics. The data of structural coordinates of hydroxyapatite crystal was put into a protein graphics program in A units. The connection of each element, with what comes front and rear, was displayed by the shade-line erasing method, and the solid-image was expressed by the degre... | ['Computer Graphics', 'Crystallography', 'Durapatite', 'Hydroxyapatites'] | 2,557,682 | [['L01.224.108', 'L01.296.110'], ['E05.196.309', 'H01.181.529.240'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['D01.029.260.700.675.374.075.025.300', 'D01.146.360.050.300', 'D01.578.122.477', 'D01.695.625.675.650.075.025.300']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Hydatic cysts--echinococcosis]. | The case diagnosis and treatment of hydatic cyst in the right and left lobe of the liver in a 28 year old pregnant woman is described in the article. | ['Adult', 'Echinococcosis, Hepatic', 'Female', 'Humans', 'Pregnancy', 'Pregnancy Complications, Parasitic'] | 16,468,243 | [['M01.060.116'], ['C01.610.335.190.396.314', 'C01.610.518.314', 'C06.552.664.272'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['C01.610.718', 'C13.703.700.680']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Neomycin inhibits glycoprotein C (gC)-dependent binding of herpes simplex virus type 1 to cells and also inhibits postbinding events in entry. | Previous studies have identified requirements for the binding of herpes simplex virus type 1 (HSV-1) to cells, including the presence of particular glycoproteins in the virion envelope (gC or gB) and the presence of particular glycosaminoglycan chains (principally heparan sulfate) on cell surface proteoglycans. We show... | ['Animals', 'Cell Line', 'Cricetinae', 'Heparin', 'Heparitin Sulfate', 'Herpesvirus 1, Human', 'Mutation', 'Neomycin', 'Protein Binding', 'Viral Envelope Proteins', 'Viral Plaque Assay'] | 8,030,274 | [['B01.050'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['D09.698.373.400'], ['D09.698.373.425'], ['B04.280.382.100.750.390'], ['G05.365.590'], ['D09.408.051.623'], ['G02.111.679', 'G03.808'], ['D09.400.430.968', 'D12.776.395.550.993', 'D12.776.543.550.993', 'D12.776.964.970.880'], ['E01.370.225.875... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oligoclonal CD8+ T cells play a critical role in the development of hypertension. | Recent studies have emphasized a role of adaptive immunity, and particularly T cells, in the genesis of hypertension. We sought to determine the T-cell subtypes that contribute to hypertension and renal inflammation in angiotensin II-induced hypertension. Using T-cell receptor spectratyping to examine T-cell receptor u... | ['Adaptive Immunity', 'Angiotensin II', 'Animals', 'CD4 Antigens', 'CD4-Positive T-Lymphocytes', 'CD8 Antigens', 'CD8-Positive T-Lymphocytes', 'Disease Models, Animal', 'Endothelium, Vascular', 'Homeodomain Proteins', 'Hypertension', 'Kidney', 'Major Histocompatibility Complex', 'Male', 'Mice', 'Mice, Knockout', 'Oligo... | 25,259,750 | [['G12.450.050'], ['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['D12.776.543.750.705.852.420.810.500', 'D12.776.543.750.830.700.025', 'D23.050.301.264.894.100', 'D23.101.100.894.100'], ['A11.118.637.555.567.5... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Parasite infracommunities of Leporinus friderici : A comparison of three tributaries of the Jurumirim Reservoir in southeastern Brazil. | The degradation and homogenization of natural habitats is considered a major cause of biotic homogenization. Many studies have been undertaken on the effects of dams on aquatic wildlife, in particular fish assemblages. But how do dams affect the parasitic fauna of such fish? The aim of the present study was to examine ... | ['Animals', 'Biodiversity', 'Brazil', 'Characiformes', 'Host-Parasite Interactions', 'Population Dynamics', 'Rivers', 'Species Specificity', 'Statistics, Nonparametric', 'Water Movements'] | 28,489,196 | [['B01.050'], ['G16.500.275.157.049', 'N06.230.124.049'], ['Z01.107.757.176'], ['B01.050.150.900.493.130'], ['G16.527.200.400'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['G16.824'], ['E05.318.740.995', 'N05.715.360.750.760', 'N06.850.520.830.995'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Tumor suppressor miR-22 suppresses lung cancer cell progression through post-transcriptional regulation of ErbB3. | BACKGROUND: Development of efficient therapies of lung cancer and deep understanding of their anti-tumor mechanism are very important. The aim of the present study is to investigate the therapeutic effect of microRNA-22 (miR-22) on lung cancer using in vitro and in vivo methods.METHODS: Expression level of miR-22 in lu... | ["3' Untranslated Regions", 'Animals', 'Base Sequence', 'Binding Sites', 'Cell Line, Tumor', 'Disease Progression', 'Gene Expression Regulation, Neoplastic', 'Genes, Tumor Suppressor', 'Humans', 'Lung Neoplasms', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'MicroRNAs', 'Receptor, ErbB-3', 'Reverse Transcriptase Polyme... | 22,484,852 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['A11.251.210.190', 'A11.251.860.180'], ['C23.550.291.656'], ['G05.308.370'], ['G05.360.340.024.340.375.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of desferrioxamine therapy on chronic disease anemia associated with rheumatoid arthritis. | OBJECTIVE: To investigate the effects of desferrioxamine (DFO) infusion on chronic disease anemia (CDA) of rheumatoid arthritis (RA) by evaluating interleukin-6 (IL-6) and erythropoietin (EPO) production.PATIENTS AND METHODS: Five patients with RA and CDA (group I) were treated with DFO, 500 mg daily, through a continu... | ['Anemia', 'Arthritis, Rheumatoid', 'Chronic Disease', 'Deferoxamine', 'Dose-Response Relationship, Drug', 'Enzyme-Linked Immunosorbent Assay', 'Erythropoietin', 'Female', 'Ferritins', 'Follow-Up Studies', 'Humans', 'Infusions, Parenteral', 'Interleukin-6', 'Iron', 'Male', 'Middle Aged', 'Siderophores', 'Treatment Outc... | 8,853,224 | [['C15.378.071'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['C23.550.291.500'], ['D02.092.570.394.265', 'D02.241.511.372.265'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D12.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A stimulatory role for cGMP-dependent protein kinase in platelet activation. | It is currently accepted that cGMP-dependent protein kinase (PKG) inhibits platelet activation. Here, we show that PKG plays an important stimulatory role in platelet activation. Expression of recombinant PKG in a reconstituted cell model enhanced von Willebrand factor (vWF)-induced activation of the platelet integrin ... | ['Animals', 'Blood Platelets', 'CHO Cells', 'Cricetinae', 'Cyclic GMP', 'Cyclic GMP-Dependent Protein Kinases', 'Humans', 'Mice', 'Mice, Knockout', 'Phosphodiesterase Inhibitors', 'Piperazines', 'Platelet Activation', 'Platelet Aggregation Inhibitors', 'Platelet Glycoprotein GPIIb-IIIa Complex', 'Platelet Glycoprotein ... | 12,526,795 | [['B01.050'], ['A11.118.188', 'A15.145.229.188'], ['A11.251.210.200', 'A11.436.155'], ['B01.050.150.900.649.313.992.635.075.250'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['D08.811.913.696.620.682.700.150.150', 'D12.644.360.200.150', 'D12.776.476.200.150'], ['B0... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exergaming Through the Eyes of Patients with Heart Failure: A Qualitative Content Analysis Study. | OBJECTIVE: Exergaming appears to be a promising tool to increase exercise capacity in patients with chronic heart failure (HF). Therefore, it is important to obtain more in-depth knowledge about preferences, attitudes, use, and abilities in regard to exergaming. The aim of this study was to describe the experiences of ... | ['Aged', 'Aged, 80 and over', 'Exercise Therapy', 'Female', 'Heart Failure', 'Humans', 'Male', 'Middle Aged', 'Qualitative Research', 'Sweden', 'Video Games'] | 28,422,516 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H01.770.644.241.850'], ['Z01.542.816.500'], ['I03.450.642.693.930', 'L01.224.900.930']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 |
Systematic Analysis of Transcriptomic Profile of the Effects of Low Dose Atropine Treatment on Scleral Fibroblasts using Next-Generation Sequencing and Bioinformatics. | This study has two novel findings: it is not only the first to deduct potential genes involved in scleral growth repression upon atropine instillation from a prevention point of view, but also the first to demonstrate that only slight changes in scleral gene expression were found after atropine treatment as side effect... | ['Atropine', 'Circadian Rhythm', 'Computational Biology', 'Extracellular Matrix', 'Fibroblasts', 'G Protein-Coupled Inwardly-Rectifying Potassium Channels', 'Gene Expression Regulation', 'Gene Regulatory Networks', 'High-Throughput Nucleotide Sequencing', 'Humans', 'MicroRNAs', 'Myopia', 'RNA, Messenger', 'Sclera', 'Tr... | 31,839,753 | [['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['G07.180.562.190'], ['H01.158.273.180', 'L01.313.124'], ['A11.284.295.310'], ['A11.329.228'], ['D12.776.157.530.400.600.450.500', 'D12.776.543.550.450.750.450.500', 'D12.776.543.585... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
A superabsorbent polymer-containing wound dressing efficiently sequesters MMPs and inhibits collagenase activity in vitro. | Superabsorbent polymer (SAP)-containing wound dressings present a valuable and unique category of wound management products. An in vitro approach was used to assess the effects of a new SAP dressing in treatment of non-healing wounds. It was shown that the SAP dressing possesses a significant binding capacity for MMP-2... | ['Absorption', 'Bandages', 'Collagenases', 'Enzyme-Linked Immunosorbent Assay', 'Extracellular Matrix', 'Humans', 'Materials Testing', 'Matrix Metalloproteinase 2', 'Matrix Metalloproteinase 9', 'Matrix Metalloproteinase Inhibitors', 'Polymers', 'Protein Binding', 'Time Factors', 'Wound Healing'] | 23,797,827 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['E07.101'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.205'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A11.284.295.310'], ['B01.050.150.900.649.313.988.400.1... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Gaussian-mixture umbrella sampling. | We introduce the Gaussian-mixture umbrella sampling method (GAMUS) , a biased molecular dynamics technique based on adaptive umbrella sampling that efficiently escapes free energy minima in multidimensional problems. The prior simulation data are reweighted with a maximum likelihood formulation, and the new approximate... | ['Alanine', 'Computer Simulation', 'Models, Chemical', 'Oligopeptides'] | 19,284,746 | [['D12.125.042'], ['L01.224.160'], ['E05.599.495'], ['D12.644.456']] | ['Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Kinetics of reduction in viability of cultured leukemia L1210 cells exposed to purine analogs. | Rates of reduction in viability and degree of cell killing were relatively independent of concentrations when replicating cultured L1210 cells were exposed to increasing concentrations of 6-thioguanine, 6-methylthiopurine ribonucleoside, 9-beta-D-arabinofuranosyl-9H-purine-6-thiol, or 9-ethyl-6-thiopurine. The relative... | ['Animals', 'Bone Marrow', 'Bone Marrow Cells', 'Cell Division', 'Cell Line', 'Cell Survival', 'Cells, Cultured', 'Dose-Response Relationship, Drug', 'Leukemia L1210', 'Mercaptopurine', 'Mice', 'Purines', 'Ribonucleosides', 'Thioguanine'] | 402,255 | [['B01.050'], ['A15.382.216'], ['A11.148', 'A15.378.316'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['G04.346'], ['A11.251'], ['G07.690.773.875', 'G07.690.936.500'], ['C04.557.337.372.594', 'C04.619.531.594'], ['D02.886.489.534', 'D03.633.100.759.570'], ['B01.050.150.90... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of BDNF infusion on the regulation of TrkB protein and message in adult rat brain. | Exposure of embryonic CNS neurons to BDNF in vitro causes down-regulation of TrkB protein and mRNA, and an attenuation of functional responses to acute neurotrophin stimulation. In order to investigate ligand-mediated regulation of TrkB in vivo, we infused BDNF into the midbrain, near the periaquaductal grey-dorsal rap... | ['Age Factors', 'Animals', 'Behavior, Animal', 'Biological Transport', 'Blotting, Western', 'Brain Chemistry', 'Brain-Derived Neurotrophic Factor', 'Gene Expression Regulation', 'Immunohistochemistry', 'Male', 'Mesencephalon', 'Neurons', 'Nociceptors', 'Olfactory Bulb', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley',... | 9,184,109 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['F01.145.113'], ['G03.143'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G02.111.150', 'G03.185'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['G05.308'], ['E0... | ['Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Isolation of lipase producing Bacillus sp. from olive mill wastewater and improving its enzyme activity. | The bacteria that could grow on media containing olive mill wastewater (OMW) were isolated and their lipase production capacities were investigated. The strain possessing the highest lipase activity among 17 strains grown on tributyrin agar medium was identified as Bacillus sp. The effect of initial pH on the lipase ac... | ['Agar', 'Bacillus', 'Culture Media', 'Enzymes', 'Fatty Acids', 'Hydrogen-Ion Concentration', 'Industrial Microbiology', 'Industrial Waste', 'Lipase', 'Lipolysis', 'Olea', 'Temperature', 'Time Factors', 'Triglycerides', 'Waste Disposal, Fluid'] | 17,532,131 | [['D09.698.360.041'], ['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['D27.720.470.305', 'E07.206'], ['D08.811'], ['D10.251'], ['G02.300'], ['H01.158.273.540.460', 'J01.897.120.460'], ['D20.944.420', 'N06.850.460.710.420'], ['D08.811.277.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Electrical nerve stimulation to facilitate placement of an indwelling catheter for repeated brachial plexus block in a traumatized dog. | A 10-year-old, 7 kg, male mixed breed dog was presented, following a dog fight, with open fractures of the radius and ulna and extensive skin and muscle lesions. Using electric nerve stimulation, an indwelling catheter was positioned in the axillary space and 2 mg kg(-1) bupivacaine was injected. Complete sensory and m... | ['Anesthetics, Local', 'Animals', 'Brachial Plexus', 'Bupivacaine', 'Catheterization', 'Dogs', 'Electric Stimulation', 'Infusions, Intravenous', 'Male', 'Nerve Block', 'Orthopedic Procedures'] | 17,565,577 | [['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['B01.050'], ['A08.800.800.720.050'], ['D02.065.199.239', 'D02.092.146.113.239'], ['E02.148', 'E05.157'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.723.402'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['E03.155.086.71... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Microscale swimming: the molecular dynamics approach. | The self-propelled motion of microscopic bodies immersed in a fluid medium is studied using molecular dynamics simulation. The advantage of the atomistic approach is that the detailed level of description allows complete freedom in specifying the swimmer design and its coupling with the surrounding fluid. A series of t... | ['Biomimetic Materials', 'Computer Simulation', 'Models, Theoretical', 'Movement', 'Swimming'] | 18,233,414 | [['J01.637.087'], ['L01.224.160'], ['E05.599'], ['G07.568', 'G11.427.410'], ['G11.427.410.568.800', 'G11.427.410.698.277.875', 'I03.350.875', 'I03.450.642.845.945.500']] | ['Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 |
Aldo-keto reductase 1B10 protects human colon cells from DNA damage induced by electrophilic carbonyl compounds. | Electrophilic carbonyl compounds are highly cytotoxic and genotoxic. Aldo-keto reductase 1B10 (AKR1B10) is an enzyme catalyzing reduction of carbonyl compounds to less toxic alcoholic forms. This study presents novel evidence that AKR1B10 protects colon cells from DNA damage induced by electrophilic carbonyl compounds.... | ['Acrolein', 'Aldehyde Reductase', 'Aldehydes', 'Aldo-Keto Reductases', 'Cell Line, Tumor', 'Colon', 'Colorectal Neoplasms', 'DNA Damage', 'Gene Silencing', 'Humans', 'Mutagens', 'Rectum'] | 26,969,882 | [['D02.047.122'], ['D08.811.682.047.150.700.156.500', 'D08.811.682.047.820.284.500'], ['D02.047'], ['D08.811.682.047.150.700.156', 'D08.811.682.047.820.284'], ['A11.251.210.190', 'A11.251.860.180'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307',... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. | BACKGROUND AND PURPOSE: The relationship between middle cerebral artery (MCA) flow velocity (CFV) and cerebral blood flow (CBF) is uncertain because of unknown vessel diameter response to physiological stimuli. The purpose of this study was to directly examine the effect of a simulated orthostatic stress (lower body ne... | ['Adult', 'Blood Flow Velocity', 'Carbon Dioxide', 'Cerebrovascular Circulation', 'Consciousness', 'Female', 'Humans', 'Hypercapnia', 'Hypocapnia', 'Hypotension, Orthostatic', 'Magnetic Resonance Imaging', 'Male', 'Middle Cerebral Artery', 'Pressoreceptors', 'Sympathetic Nervous System', 'Ultrasonography, Doppler, Tran... | 10,884,472 | [['M01.060.116'], ['E01.370.370.130', 'G09.330.380.630.080'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['G09.330.100.159'], ['F02.463.188.409', 'F02.830.233'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.544'], ['C23.888.852.614'], ['C10.177.575.600.450', 'C14.907.514.482'], ['E01.370.350.8... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Changes in torque and electromyographic activity of the quadriceps femoris muscles following isometric training. | BACKGROUND AND PURPOSE: The purpose of this study was to examine the effect of isometric training of the quadriceps femoris muscles, at different joint angles, on torque production and electromyographic (EMG) activity.SUBJECTS: One hundred seven women were randomly assigned to one of four groups. Three groups trained w... | ['Adult', 'Analysis of Variance', 'Electromyography', 'Exercise', 'Female', 'Humans', 'Isometric Contraction', 'Knee', 'Muscles', 'Physical Therapy Modalities'] | 8,316,579 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.405.255', 'E01.370.530.255'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494.472'], ['A01.378.610.450'], ['A02.633', 'A10.690'], ['E02.779', 'E02.831.535']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Acid hydrolases in sera and plasma from patients with cystic fibrosis. | The enzyme activities of alpha-fucosidase (pH 4.0 and pH 5.5), alpha-galactosidase, beta-galactosidase, alpha-glucosidase (pH 4.5 and pH 6.0), beta-glucosidase, beta-glucuronidase, beta-hexosaminidase, and alpha-mannosidase (pH 4.5 and pH 5.5) were investigated in sera from cystic fibrosis (CF) patients. Several of the... | ['Acid Phosphatase', 'Cystic Fibrosis', 'Glucuronidase', 'Hexosaminidases', 'Hot Temperature', 'Humans', 'Hydrogen-Ion Concentration', 'Hydrolases', 'Isoenzymes', 'Mannosidases', 'alpha-Galactosidase', 'alpha-Glucosidases', 'alpha-L-Fucosidase', 'beta-Galactosidase', 'beta-Glucosidase'] | 6,263,520 | [['D08.811.277.352.650.025'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['D08.811.277.450.426'], ['D08.811.277.450.483'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis. | BACKGROUND: In 2007 the World Cancer Research Fund Report concluded that there was limited and inconsistent evidence for an effect of coffee and tea consumption on the risk of epithelial ovarian cancer (EOC).OBJECTIVE: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we aimed to investigate w... | ['Carcinoma, Ovarian Epithelial', 'Coffee', 'Endpoint Determination', 'Female', 'Follow-Up Studies', 'Humans', 'Interviews as Topic', 'Neoplasms, Glandular and Epithelial', 'Ovarian Neoplasms', 'Prevalence', 'Proportional Hazards Models', 'Prospective Studies', 'Risk Factors', 'Surveys and Questionnaires', 'Tea'] | 22,440,851 | [['C04.557.470.200.295', 'C04.588.322.455.199', 'C13.351.500.056.630.705.350', 'C13.351.937.418.685.350', 'C19.344.410.199', 'C19.391.630.705.350'], ['D20.215.784.249', 'G07.203.100.325', 'J02.200.325'], ['E05.315'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.15... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Novel human G-protein-coupled receptors. | G-protein-coupled receptors (GPCRs) are important mediators of signal transduction and targets for pharmacological therapeutics. Novel receptor-ligand systems have been discovered through the identification and analysis of orphan GPCRs (oGPCRs). Here we describe the discovery of seven novel human genes encoding oGPCRs.... | ['Amino Acid Sequence', 'Cloning, Molecular', 'Heterotrimeric GTP-Binding Proteins', 'Humans', 'Molecular Sequence Data', 'RNA, Messenger', 'Receptors, Odorant', 'Sequence Alignment', 'Tissue Distribution'] | 12,732,197 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.220'], ['D08.811.277.040.330.300.200', 'D12.644.360.360', 'D12.776.157.325.332', 'D12.776.476.375', 'D12.776.543.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['D13.444.735.544'], ['D12.776.543.750.695.600'], ['E05.393.751'], ['G03.78... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Electron-microscopic study of gamma-aminobutyric acid immunoreactivity in the chief cells of the mouse carotid body. | The present study shows gamma-aminobutyric acid (GABA) immunoreactivity in almost all chief cells of the mouse carotid body. GABA immunoreaction products were distributed diffusely in the cytoplasm as well as in the dense-cored granules. These findings suggest that GABA may be localized in the cytoplasm and granules, a... | ['Animals', 'Carotid Body', 'Cytoplasm', 'Cytoplasmic Granules', 'Immunohistochemistry', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Microscopy, Electron', 'Microscopy, Immunoelectron', 'gamma-Aminobutyric Acid'] | 8,722,514 | [['B01.050'], ['A08.675.650.915.500.600.150', 'A08.800.950.500.600.150', 'A11.671.650.915.500.600.150'], ['A11.284.430.214'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.6... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Establishing consistency across all regions in a multi-regional clinical trial. | In recent years, global collaboration has become a conventional strategy for new drug development. To accelerate the development process and shorten approval time, the design of multi-regional clinical trials (MRCTs) incorporates subjects from many countries/regions around the world under the same protocol. After showi... | ['Clinical Trials as Topic', 'Drug Approval', 'Drug Design', 'Humans', 'International Cooperation', 'Japan', 'Multicenter Studies as Topic', 'Research Design', 'Time Factors'] | 22,504,851 | [['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.290.250', 'E05.337.300', 'I01.880.604.605.250.250'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615.500'], ['Z01.252.474.463', 'Z01.639.595'], ['E05.318.37... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Spoken english language development among native signing children with cochlear implants. | Bilingualism is common throughout the world, and bilingual children regularly develop into fluently bilingual adults. In contrast, children with cochlear implants (CIs) are frequently encouraged to focus on a spoken language to the exclusion of sign language. Here, we investigate the spoken English language skills of 5... | ['Child', 'Child, Preschool', 'Cochlear Implants', 'Deafness', 'Humans', 'Language Development', 'Multilingualism', 'Persons With Hearing Impairments', 'Sign Language', 'Speech'] | 24,150,489 | [['M01.060.406'], ['M01.060.406.448'], ['E07.305.250.319.381.500.500', 'E07.695.150', 'E07.695.202.381.500.500', 'E07.814.458.150'], ['C09.218.458.341.186', 'C10.597.751.418.341.186', 'C23.888.592.763.393.341.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.525.200.310'], ['L01.559.423.452'], ['M01.150.750... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Cloning, purification and preliminary X-ray data analysis of the human ID2 homodimer. | The ID proteins are named for their role as inhibitors of DNA binding and differentiation. They contain a helix-loop-helix (HLH) domain but lack a basic DNA-binding domain. In complex with basic HLH (bHLH) transcription factors, gene expression is regulated by DNA-binding inactivation. Although the HLH domain is highly... | ['Amino Acid Motifs', 'Amino Acid Sequence', 'Binding, Competitive', 'Chromatography, Affinity', 'Cloning, Molecular', 'Conserved Sequence', 'Crystallization', 'Crystallography, X-Ray', 'DNA', 'Humans', 'Inhibitor of Differentiation Protein 2', 'Protein Binding', 'Protein Interaction Domains and Motifs', 'Protein Multi... | 23,143,248 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['E05.196.181.400.170'], ['E05.393.220'], ['G02.111.570.580'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D13.444.308'], ['B01.050.150.900.649.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Halocycloalkenones as Diels-Alder dienophiles. Applications to generating useful structural patterns. | Halocycloalkenones are demonstrated to function as potent dienophiles in inter- and intramolecular Diels-Alder cycloadditions. We have found 2-brominated cycloalkenone dienophiles to be both highly endo selective and significantly more reactive than their nonhalogenated parent compounds. A method for the facile convers... | ['Cyclization', 'Cycloparaffins', 'Hydrocarbons, Halogenated', 'Stereoisomerism'] | 23,151,095 | [['G02.111.180', 'G02.607.133', 'G03.208'], ['D02.455.426.392.368', 'D04.345.133'], ['D02.455.526'], ['G02.607.445.682']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lifetime burden of mood swings and activation of brain norepinephrine turnover in patients with treatment-refractory depressive illness. | BACKGROUND: We tested if duration and intensity of episodes in treatment-resistant affectively ill patients were related to cerebrospinal fluid (CSF) concentrations of monoamine metabolites.METHOD: In retrospective life charts were recorded every previous episode of 37 patients with severe treatment-refractory affectiv... | ['Antidepressive Agents', 'Brain', 'Depressive Disorder', 'Drug Resistance', 'Female', 'Homovanillic Acid', 'Humans', 'Male', 'Methoxyhydroxyphenylglycol', 'Middle Aged', 'Mood Disorders', 'Norepinephrine', 'Retrospective Studies', 'Spinal Puncture'] | 12,706,520 | [['D27.505.954.427.700.122'], ['A08.186.211'], ['F03.600.300'], ['G07.690.773.984'], ['D02.241.223.601.521'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.455.250.610'], ['M01.060.116.630'], ['F03.600'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', 'D02.092.311.830', 'D02.455.426.559.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Immunogenicity characterization of genetically fused or chemically conjugated heat-stable toxin toxoids of enterotoxigenic Escherichia coli in mice and pigs. | Enterotoxigenic Escherichia coli (ETEC) producing type Ib heat-stable toxin (STa) are a main cause of children's diarrhea and travelers' diarrhea, thus STa needs to be targeted in ETEC vaccine development. However, because this 19-amino acid STa is poorly immunogenic, attempts to genetically fuse or chemically couple i... | ['Animals', 'Antibodies, Bacterial', 'Conjugation, Genetic', 'Enterotoxigenic Escherichia coli', 'Escherichia coli Infections', 'Gene Fusion', 'Immunogenicity, Vaccine', 'Mice', 'Swine', 'Toxoids'] | 30,772,899 | [['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['G05.728.200'], ['B03.440.450.425.325.300.340', 'B03.660.250.150.180.100.340'], ['C01.150.252.400.310.330'], ['G05.728.385'], ['G12.513'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells. | Although it is well established that immature B lymphocytes are exquisitely sensitive to tolerance induction compared with their mature counterparts, the molecular basis for this difference is unknown. We demonstrate that signaling by B cell antigen receptors leads to distinct and mutually exclusive biologic responses ... | ['Animals', 'Antigens, CD', 'Antigens, Differentiation, T-Lymphocyte', 'B-Lymphocytes', 'B7-2 Antigen', 'Cell Differentiation', 'Gene Expression Regulation', 'Histocompatibility Antigens Class II', 'Lectins, C-Type', 'Membrane Glycoproteins', 'Mice', 'Mice, Transgenic', 'RNA Editing', 'Receptors, Antigen, B-Cell', 'Up-... | 10,499,913 | [['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.894', 'D23.101.100.894'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D12.776.465.500', 'D12.776.467.150.200', 'D12.776.543.095.200', 'D23.050.301.285.200', 'D23.529... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cefotaxime and Amoxicillin-Clavulanate Synergism against Extended-Spectrum-â-Lactamase-Producing Escherichia coli in a Murine Model of Urinary Tract Infection. | We investigated the efficacies of cefotaxime (CTX) and amoxicillin (AMX)-clavulanate (CLA) (AMC) against extended-spectrum-â-lactamase (ESBL)-producing Escherichia coli in vitro and in a murine model of urinary tract infection (UTI). MICs, the checkerboard dilution method, and time-kill curves were used to explore the ... | ['Amoxicillin-Potassium Clavulanate Combination', 'Animals', 'Anti-Bacterial Agents', 'Cefotaxime', 'Disease Models, Animal', 'Drug Synergism', 'Drug Therapy, Combination', 'Female', 'Gene Expression', 'Humans', 'Imipenem', 'Mice', 'Mice, Inbred CBA', 'Microbial Sensitivity Tests', 'Plasmids', 'Pyelonephritis', 'Urinar... | 26,525,800 | [['D02.065.589.099.374.160.060', 'D02.065.589.099.750.750.050.050.060', 'D02.886.108.750.750.050.050.060', 'D03.633.100.300.374.160.060', 'D03.633.100.300.750.750.050.050.500', 'D26.310.102'], ['B01.050'], ['D27.505.954.122.085'], ['D02.065.589.099.249.190.190', 'D02.886.665.074.190.190', 'D03.633.100.300.249.190.190']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The reported incidence of work-related ill-health in Scotland (2002-2003). | BACKGROUND: Although incidence data for work-related ill-health in the UK are available, more detailed information for smaller geographical areas has hitherto been unpublished.AIMS: To estimate the incidence of work-related ill-health reported by clinical specialists in Scotland, 2002-2003.METHODS: THOR (The Health and... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Dermatitis, Occupational', 'Female', 'Humans', 'Incidence', 'Male', 'Mental Disorders', 'Middle Aged', 'Musculoskeletal Diseases', 'Occupational Diseases', 'Scotland', 'Sex Distribution'] | 15,982,973 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['C17.800.174.255.700', 'C17.800.815.255.700', 'C24.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.98... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Sexual orientation in the school environment: fact or eagerness?]. | This qualitative research aims to analyze how sexual orientation has been incorporated into pedagogic practices through the point of view of educators from public schools of fundamental teaching. Twenty three educators from Cajazeiras, Paralba, Brazil participated in the study. The focus group was elected as technique ... | ['Attitude', 'Faculty', 'Humans', 'Sex Education', 'Sexual Behavior'] | 21,888,210 | [['F01.100'], ['M01.526.702.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.096.837.500', 'I02.233.332.749'], ['F01.145.802']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems. | The question of how the cerebral cortex responds over time to changes in cortical neuronal number was addressed by inducing excitotoxic cortical neuronal loss, either alone or followed by homotypic fetal cortical cell suspension grafts, in adult rats. Following neuronal cell loss, rapid gliosis and inflammation tempora... | ['Afferent Pathways', 'Analysis of Variance', 'Animals', 'Axonal Transport', 'Cerebral Cortex', 'Choline O-Acetyltransferase', 'Female', 'Glutamate Decarboxylase', 'Glutamates', 'Glutamic Acid', 'Kainic Acid', 'N-Methylaspartate', 'Nerve Degeneration', 'Nerve Regeneration', 'Neurons', 'Neurotoxins', 'Norepinephrine', '... | 1,379,936 | [['A08.612.220'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['G03.143.355.040', 'G04.392.040', 'G11.561.050'], ['A08.186.211.200.885.287.500'], ['D08.811.913.050.134.180'], ['D08.811.520.224.125.250'], ['D12.125.067.625', 'D12.125.119.409'], ['D12.125.067.625.349', 'D12.125.119.409... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
CYP17 MspA1 polymorphism and age at menarche: a meta-analysis. | OBJECTIVE: Literature data on the effects of CYP17 MspA1 polymorphism on age at menarche (AAM) are inconsistent. To reexamine this controversy, we performed a meta-analysis.STUDY DESIGN: In total 16 studies containing more than 11000 individuals of various ethnicities were selected for the analyses. For 11 case-control... | ['Age Factors', 'Case-Control Studies', 'Female', 'Humans', 'Menarche', 'Polymorphism, Genetic', 'Risk Factors', 'Steroid 17-alpha-Hydroxylase'] | 18,957,719 | [['N05.715.350.075', 'N06.850.490.250'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.760.410', 'G08.686.841.374.410'], ['G05.365.795'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
In vivo quantification of T1ñ in lumbar spine disk spaces at 3 T using parallel transmission MRI. | OBJECTIVE: T1ñ MRI is an emerging, quantitative imaging modality that has been shown to correlate with proteoglycan content of disk material in vitro at 1.5 T. The purpose of this study is to quantify T1ñ values at all lumbar spine disk space levels at 3 T with parallel-transmission MRI in healthy adult volunteers.SUBJ... | ['Adult', 'Female', 'Humans', 'Intervertebral Disc', 'Linear Models', 'Lumbar Vertebrae', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged'] | 23,789,682 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.165.308.410', 'A02.835.232.834.432', 'A10.165.382.350.050'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['A02.835.2... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
First report of Legionella pneumophila in car cabin air filters. Are these a potential exposure pathway for professional drivers? | Recent findings have identified professional drivers as being at an increased risk of Legionnaires' disease. Our hypothesis was that used car cabin air filters represent a reservoir of Legionella bacteria, and thus a potential pathway for contamination. We analysed used cabin air filters from various types of car. The ... | ['Air Filters', 'Automobiles', 'Legionella pneumophila'] | 24,099,652 | [['E05.196.454.201', 'E07.039'], ['J01.937.500.100'], ['B03.440.400.425.450.450.500', 'B03.660.250.460.460.580']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Catalysis with phosphine-containing amino acids in various "turn" motifs. | We have been actively involved in the development of parallel approaches for the discovery of phosphine ligands. Our approach has been based on the incorporation of phosphine-containing amino acids into peptide sequences that are designed to have stable secondary structures. We have examined helical and turn secondary ... | ['Amino Acid Sequence', 'Amino Acids', 'Catalysis', 'Ligands', 'Models, Molecular', 'Oligopeptides', 'Phosphines', 'Protein Structure, Secondary', 'Stereoisomerism'] | 15,527,293 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.125'], ['G02.130'], ['D27.720.470.480'], ['E05.599.595'], ['D12.644.456'], ['D01.695.525', 'D02.705.621'], ['G02.111.570.820.709.600'], ['G02.607.445.682']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Subtype-specific regulatory network rewiring in acute myeloid leukemia. | Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. To determine how different mutant regulators establish AML subtype-specific transcriptional networks, we performed a comprehensive global analysis of cis-re... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Gene Expression Regulation, Leukemic', 'Gene Regulatory Networks', 'Humans', 'Leukemia, Myeloid, Acute', 'Male', 'Middle Aged', 'Signal Transduction', 'Transcription Factors', 'Young Adult'] | 30,420,649 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G05.308.370.500'], ['G05.360.080.689.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275'], ['M01.060.116.630'], ['G02.111.820', 'G04.835'], ['D12.776.930'], ['M01.060.116.815']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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