Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Laryngeal involvement in rheumatoid arthritis. | Twenty-nine female patients with definite or classical rheumatoid arthritis (RA) and 30 controls were studied in order to assess the prevalence of laryngeal involvement in patients with RA and the occurrence of extrathoracic airway obstruction. Laryngeal involvement was assessed by physical examination including direct... | ['Adult', 'Aged', 'Airway Obstruction', 'Arthritis, Rheumatoid', 'Female', 'Humans', 'Laryngeal Diseases', 'Laryngoscopy', 'Middle Aged', 'Physical Examination', 'Prevalence', 'Random Allocation', 'Respiratory Function Tests', 'Surveys and Questionnaires'] | 1,759,587 | [['M01.060.116'], ['M01.060.116.100'], ['C08.618.846.185'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.360', 'C09.400'], ['E01.370.386.460', 'E01.370.388.250.525', 'E04.502.250.525', 'E04.580.373'], ['M01.060.116.630'], ['E01.370.600'], [... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Adipose cellularity, serum glucose, insulin and cholesterol in polygenic obese mice fed high-fat or high-carbohydrate diets. | Polygenic obese (M16) and nonobese (ICR) mice were fed ad libitum either a high-fat (FAT) or high-carbohydrate (CHO) diet from 6 to 10 weeks of age. After this four-week period, M16 exceeded (P less than 0.01) ICR mice and FAT-fed exceeded (P less than 0.01) CHO-fed mice in body energy percent, body fat percent, and we... | ['Adipose Tissue', 'Animals', 'Blood Glucose', 'Body Weight', 'Cholesterol', 'Dietary Carbohydrates', 'Dietary Fats', 'Fatty Acid Synthases', 'Insulin', 'Lipoprotein Lipase', 'Mice', 'Mice, Obese', 'Obesity'] | 7,030,875 | [['A10.165.114'], ['B01.050'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D10.212.302', 'G07.... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Skeletal muscle contractile characteristics and fatigue resistance in patients with chronic heart failure. | Whole muscle contractile characteristics and fatigue resistance were studied in male patients with chronic heart failure (n = 6) and in healthy control subjects (n = 6). Maximum voluntary isometric strength in the major muscle groups of leg (plantar flexors and knee extensors) and arm (elbow extensors and elbow flexors... | ['Chronic Disease', 'Exercise', 'Fatigue', 'Hand Strength', 'Heart Failure', 'Humans', 'Male', 'Middle Aged', 'Muscle Contraction', 'Muscle, Skeletal', 'Reference Values'] | 8,781,829 | [['C23.550.291.500'], ['G11.427.410.698.277', 'I03.350'], ['C23.888.369'], ['E01.370.600.425.500', 'G11.427.560.500'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G11.427.494'], ['A02.633.567', 'A10.690.552.500'], ['E05.978.810']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Perinatal outcome of sacrococcygeal teratoma. | OBJECTIVE: To evaluate the outcome in a cohort of fetuses with isolated sacrococcygeal teratoma (SCT) in relation to the need for in utero intervention.METHODS: We retrospectively analyzed a cohort of fetuses prenatally diagnosed with SCT between September 2000 and December 2010. Postnatal outcomes were evaluated in re... | ['Abdominal Neoplasms', 'Catheter Ablation', 'Cohort Studies', 'Female', 'Fetal Diseases', 'Fetal Therapies', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Infant, Premature, Diseases', 'Male', 'Postoperative Complications', 'Pregnancy', 'Premature Birth', 'Retrospective Studies', 'Sacrococcygeal Region', 'Teratom... | 22,024,911 | [['C04.588.033'], ['E02.808.750.500', 'E04.014.760.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C13.703.277', 'C16.300'], ['E02.467'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['C16.614.521'], ['C23.550.767'], ['G08.686.784... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Health-related quality of life in adults with congenital unilateral upper limb deficiency in Norway. A cross-sectional study. | PURPOSE: To examine subjective health-related quality of life (HRQoL) in adults with congenital unilateral upper limb deficiency (UULD) in Norway and to explore the associations between demographic and clinical factors and HRQoL.METHOD: Cross-sectional study comparing HRQoL, measured by SF-36, among adults with UULD an... | ['Adult', 'Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Chronic Pain', 'Comorbidity', 'Cross-Sectional Studies', 'Emotions', 'Employment', 'Female', 'Humans', 'Linear Models', 'Male', 'Mental Health', 'Middle Aged', 'Norway', 'Psychiatric Status Rating Scales', 'Quality of Life', 'Surveys and Questionnaires', '... | 26,778,109 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.888.592.612.274'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.470'], ['N01.824.245'], ['B... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Role of neuronal and inducible nitric oxide synthases in the guinea pig ileum myenteric plexus during in vitro ischemia and reperfusion. | BACKGROUND: Intestinal ischemia and reperfusion (I/R) injury leads to abnormalities in motility, namely delay of transit, caused by damage to myenteric neurons. Alterations of the nitrergic transmission may occur in these conditions. This study investigated whether an in vitro I/R injury may affect nitric oxide (NO) pr... | ['Animals', 'Blotting, Western', 'Guinea Pigs', 'Ileum', 'Immunohistochemistry', 'Male', 'Myenteric Plexus', 'Nitric Oxide', 'Nitric Oxide Synthase Type I', 'Nitric Oxide Synthase Type II', 'RNA, Messenger', 'Real-Time Polymerase Chain Reaction', 'Reperfusion Injury', 'Reverse Transcriptase Polymerase Chain Reaction'] | 23,279,126 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.992.550'], ['A03.556.124.684.249', 'A03.556.249.124'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Atrazine toxicity on hydromineral balance of fish, Tilapia mossambicus. | The chronic effects of atrazine on total body weight, hydration level, and serum inorganic electrolytes in the tissues of freshwater fish, Tilapia mossambicus, were studied. Significant changes were observed in the tissues indicating the disturbances in the hydromineral balance of the fish as a consequence of atrazine. | ['Animals', 'Atrazine', 'Body Water', 'Body Weight', 'Electrolytes', 'Tilapia', 'Water Pollutants, Chemical'] | 7,525,225 | [['B01.050'], ['D03.383.931.247'], ['A12.207.200'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D01.248'], ['B01.050.150.900.493.602.200.800'], ['D27.888.284.903.655']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The influence of Parkinson's disease on the functional connectivity of the motor loop of human basal ganglia. | Current basal ganglia models integrate information obtained from humans and animals to explain motor disorders in Parkinson's disease. These models explain some motor disturbances of Parkinson's disease (PD), but different clinical observations which remain unexplained have promoted the development of new basal ganglia... | ['Adult', 'Aged', 'Basal Ganglia', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neural Pathways', 'Parkinson Disease'] | 30,833,228 | [['M01.060.116'], ['M01.060.116.100'], ['A08.186.211.200.885.287.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['A08.612'], ['C10.228.140.079.862.500', 'C10.228.662.600.400', 'C10.574.928.750']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Surgical management of congenital heart disease: correlation between hospital costs and the Aristotle complexity score. | BACKGROUND: Hospital costs are expected to correlate with clinical complexity. Do costs for congenital heart surgery correlate with Aristotle complexity scores?METHODS: 442 inpatient stays in 2008 were evaluated. Aristotle scores and levels were determined. Costs were estimated according to the German Institute for Hos... | ['Cardiac Surgical Procedures', 'Critical Care', 'Germany', 'Heart Defects, Congenital', 'Hospital Costs', 'Hospital Mortality', 'Humans', 'Infant', 'Infant, Newborn', 'Inpatients', 'Insurance, Health, Reimbursement', 'Length of Stay', 'Models, Economic', 'Respiration, Artificial', 'Risk Assessment', 'Risk Factors', 'S... | 20,824,582 | [['E04.100.376', 'E04.928.220'], ['E02.760.190', 'N02.421.585.190'], ['Z01.542.315'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['N03.219.151.400.687', 'N03.219.262.500', 'N05.300.375.500'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['B01.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
E. coli SSB activates N4 virion RNA polymerase promoters by stabilizing a DNA hairpin required for promoter recognition. | Bacteriophage N4 virion RNA polymerase transcription of double-stranded promoter-containing DNAs requires supercoiled template and E. coli single-stranded DNA-binding protein (EcoSSB); other single-stranded DNA-binding proteins cannot substitute. The DNA determinants of virion RNA polymerase binding at the promoter com... | ['Base Sequence', 'DNA Footprinting', 'DNA, Bacterial', 'DNA, Single-Stranded', 'DNA, Viral', 'DNA-Binding Proteins', 'DNA-Directed RNA Polymerases', 'Deoxyribonuclease I', 'Escherichia coli', 'Gene Expression Regulation, Bacterial', 'Gene Expression Regulation, Viral', 'Molecular Sequence Data', 'Nucleic Acid Conforma... | 8,548,819 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.300'], ['D13.444.308.212'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['D13.444.308.568'], ['D12.776.260'], ['D08.811.913.696.445.735.270'], ['D08.811.277.352.335.350.250'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.10... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Adolescent bisphenol-A exposure decreases dendritic spine density: role of sex and age. | Bisphenol-A (BPA), a common environmental endocrine disruptor, modulates estrogenic, androgenic, and antiandrogenic effects throughout the lifespan. We recently showed that low dose BPA exposure during adolescence increases anxiety and impairs spatial memory independent of sex. In this study, six week old Sprague Dawle... | ['Age Factors', 'Animals', 'Benzhydryl Compounds', 'CA1 Region, Hippocampal', 'Corticosterone', 'Dendritic Spines', 'Endocrine Disruptors', 'Female', 'Male', 'Phenols', 'Prefrontal Cortex', 'Pyramidal Cells', 'Rats', 'Rats, Sprague-Dawley', 'Sex Factors'] | 24,975,924 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['D02.455.426.559.389.115'], ['A08.186.211.180.405.099', 'A08.186.211.200.885.287.500.345.099'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['A08.675.256.200', 'A11.284.180.225.169', 'A11.671.240.169'], ['D27.505.696.353', 'D27.888.141'], ['D02.455.... | ['Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Three-dimensional changes of the upper airway in patients with Class II malocclusion treated with the Herbst appliance: A cone-beam computed tomography study. | INTRODUCTION: This study aimed to determine the volumetric effects on the upper airways of growing patients with Class II malocclusion treated with the Herbst appliance (HA).METHODS: Volumetric measurements of the upper airways of 42 skeletal Class II malocclusion patients (mean age: 13.8 ± 1.2 years; ranging from 12.0... | ['Adolescent', 'Cephalometry', 'Child', 'Cone-Beam Computed Tomography', 'Humans', 'Malocclusion, Angle Class II', 'Mandible', 'Mandibular Advancement', 'Oropharynx', 'Orthodontic Appliances, Functional'] | 32,005,472 | [['M01.060.057'], ['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['M01.060.406'], ['E01.370.350.700.810.810.490', 'E01.370.350.825.810.810.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C07.793.494.630'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['E04.545.500', 'E06.645.500', 'E06.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Placenta-breast cancer cell interactions promote cancer cell epithelial mesenchymal transition via TGFâ/JNK pathway. | Women diagnosed with pregnancy associated breast cancer often have advanced cancer with metastases and reduced expression of ERá compared to non-pregnant women. Nevertheless, metastases to the placenta are uncommon. Previously, we demonstrated that breast cancer cells (MCF-7/T47D) migrated from ex vivo human placental ... | ['Apoptosis', 'Blotting, Western', 'Breast Neoplasms', 'Cell Communication', 'Cell Cycle', 'Cell Movement', 'Cell Proliferation', 'Coculture Techniques', 'Epithelial-Mesenchymal Transition', 'Female', 'Flow Cytometry', 'Humans', 'Immunoenzyme Techniques', 'JNK Mitogen-Activated Protein Kinases', 'Placenta', 'Pregnancy'... | 25,316,285 | [['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C04.588.180', 'C17.800.090.500'], ['G04.085'], ['G04.144'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.481.500.374'], ['G04.356.500'], ['E01.370.225.500.363.342... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The impact of workplace factors on evidence-based speech-language pathology practice for children with autism spectrum disorders. | Although researchers have examined barriers to implementing evidence-based practice (EBP) at the level of the individual, little is known about the effects workplaces have on speech-language pathologists' implementation of EBP. The aim of this study was to examine the impact of workplace factors on the use of EBP among... | ['Attitude of Health Personnel', 'Child', 'Child Behavior', 'Child Development Disorders, Pervasive', 'Communication', 'Educational Status', 'Evidence-Based Practice', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Private Sector', 'Professional Competence', 'Professional-Patient Relations', 'Speech-Language Patho... | 22,967,045 | [['F01.100.050', 'N05.300.100'], ['M01.060.406'], ['F01.145.179'], ['F03.625.164'], ['F01.145.209', 'L01.143'], ['N01.824.196'], ['H02.249'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.791', 'N04.452.633.390'], ['I02.399.630'], ['F01.829.401.650', 'N05.300.660'], ['H0... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Erythropoiesis inhibitor in a patient with hereditary spherocytosis. | The studies dealt with the effect of plasma of a patient with congenital haemolytic anaemia on the erythropoiesis in mice. The materials included the plasma from the patient before and after splenctomy and the spleen homogenate and the spleen subcellular fractions. The effect of the materials was evaluated with the amo... | ['Adolescent', 'Animals', 'Erythropoiesis', 'Humans', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Spherocytosis, Hereditary', 'Splenectomy', 'Time Factors'] | 1,230,400 | [['M01.060.057'], ['B01.050'], ['G04.152.825.414', 'G09.188.343.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['C15.378.071.141.150.785', 'C16.320.070.785'], ['E04.726'], ['G01.910.... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Radiation-induced salivary gland dysfunction results from p53-dependent apoptosis. | PURPOSE: Radiotherapy for head-and-neck cancer causes adverse secondary side effects in the salivary glands and results in diminished quality of life for the patient. A previous in vivo study in parotid salivary glands demonstrated that targeted head-and-neck irradiation resulted in marked increases in phosphorylated p... | ['Animals', 'Apoptosis', 'Apoptosis Regulatory Proteins', 'Caspase 3', 'Dose-Response Relationship, Radiation', 'Enzyme Activation', 'Female', 'Genes, p53', 'Membrane Proteins', 'Mice', 'Mice, Knockout', 'Mice, Transgenic', 'Parotid Gland', 'Proto-Oncogene Proteins c-akt', 'RNA, Messenger', 'Salivary Glands', 'Tumor Su... | 19,147,016 | [['B01.050'], ['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Atomic force microscopy as a tool to study the proteasome assemblies. | Proteasome is an exceptional enzyme because of its essential physiological role, multiple activities, and structural complexity. It is, in fact, a family of enzymes sharing a common catalytic core and equipped with distinct protein attachments regulating the core and adding to its new functional capabilities. As a drug... | ['Enzymes, Immobilized', 'Humans', 'Ligands', 'Microscopy, Atomic Force', 'Proteasome Endopeptidase Complex', 'Protein Conformation', 'Protein Subunits', 'Saccharomyces cerevisiae'] | 19,195,545 | [['D08.811.180', 'D12.776.463.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.480'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['D05.500.562.500', 'D08.811.277.656.918', 'D08.811.600.730'], ['G02.111.570.820.709'], ['D12.776.813'], ['B01.300.107.795.785.800', 'B01.300.930.705.655']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immunofluorescence of mineralocorticoid receptors in peripheral lymphocytes: presence of receptor-like activity in patients with the autosomal dominant form of pseudohypoaldosteronism, and its absence in the recessive form. | Pseudohypoaldosteronism is a syndrome characterized by salt wasting and a failure to thrive due to the resistance towards the action of aldosterone. Aldosterone levels and plasma renin activity are extremely elevated and aldosterone binding sites in peripheral mononuclear leukocytes have regularly shown to be reduced o... | ['Adult', 'Child', 'Child, Preschool', 'Female', 'Fluorescent Antibody Technique', 'Genes, Dominant', 'Genes, Recessive', 'Humans', 'Infant', 'Lymphocytes', 'Male', 'Pseudohypoaldosteronism', 'Receptors, Mineralocorticoid'] | 7,826,888 | [['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.360.340.024.340.415', 'G05.420.325'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of two anti-Thy 1.1-abrin A-chain immunotoxins prepared with different cross-linking agents: antitumor effects, in vivo fate, and tumor cell mutants. | The A-chain of the plant toxin abrin was covalently linked to monoclonal anti-Thy 1.1 antibody (OX7) with the use of either N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP) or 2-iminothiolane hydrochloride (2IT). The SPDP reagent generates a linkage containing a disulfide bond and an amide bond, whereas the 2IT reag... | ['Abrin', 'Animals', 'Antigens, Surface', 'Cell Survival', 'Cross-Linking Reagents', 'Immunotoxins', 'Isoantibodies', 'Lymphoma', 'Metabolic Clearance Rate', 'Mice', 'Mice, Inbred AKR', 'Mice, Inbred BALB C', 'Neoplasms, Experimental', 'Plant Proteins', 'Thy-1 Antigens', 'Tumor Cells, Cultured'] | 2,890,786 | [['D08.811.277.450.430.700.750.111', 'D12.776.503.499.249', 'D12.776.765.678.906.111'], ['B01.050'], ['D23.050.301'], ['G04.346'], ['D27.720.470.410.210'], ['D12.776.124.790.651.114.580.450', 'D12.776.377.715.548.114.580.450', 'D27.888.569.257.500'], ['D12.776.124.486.485.114.664', 'D12.776.124.790.651.114.664', 'D12.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapidly growing mycobacteria infection in patients with cancer. | BACKGROUND: Rapidly growing mycobacteria (RGM) have been associated with various clinical syndromes in immunocompetent and immunocompromised hosts. The risk factors and outcomes of RGM infection in patients with cancer have not been clearly defined.METHODS: Data were derived from 2 distinct sources. Demographic and cli... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antitubercular Agents', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Mycobacterium Infections', 'Neoplasms', 'Prognosis', 'Risk Factors', 'Treatment Outcome'] | 20,617,902 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085.255'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.116.630'], ['C01.150.252.410.040.552'], ['C04'], ['E01.789'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
19p+ marker chromosome correlates with relapse in malignant fibrous histiocytoma. | In this study, we examined the relationship of 19p13 aberrations, usually leading to addition of unknown material (19p+), and ring chromosomes to clinical outcome in patients with malignant fibrous histiocytoma (MFH). Analysis of 69 MFHs revealed 19 tumors with 19p+ and 24 tumors with ring chromosomes. After a median f... | ['Adult', 'Aged', 'Aged, 80 and over', 'Chromosome Aberrations', 'Chromosomes, Human, Pair 19', 'Female', 'Follow-Up Studies', 'Head and Neck Neoplasms', 'Histiocytoma, Benign Fibrous', 'Humans', 'Karyotyping', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Prognosis', 'Retroperitoneal Neoplasms', 'Ring Chromoso... | 8,818,655 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.210', 'G05.365.590.175'], ['A11.284.187.520.300.460.465', 'G05.360.162.520.300.460.465'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C04.588.443'], ['C04.557.450.565.590.425.350'], ['B01.050.150.9... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Four-kilobase sequence of the mouse CNP gene directs spatial and temporal expression of lacZ in transgenic mice. | The gene encoding 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin genes to be expressed in the brain. It is expressed at basal levels in some non-neural tissues but at much higher levels in the nervous system, and its relevance and mechanism are unknown. Using transgenic mice, we examin... | ['Aging', 'Animals', 'Brain', 'Embryonic and Fetal Development', 'Exons', 'Gene Expression Regulation, Enzymologic', 'Genes, Reporter', 'Male', 'Mice', 'Mice, Transgenic', 'Natriuretic Peptide, C-Type', 'Oligodendroglia', 'Organ Specificity', 'Recombinant Fusion Proteins', 'Reverse Transcriptase Polymerase Chain Reacti... | 9,710,259 | [['G07.345.124'], ['B01.050'], ['A08.186.211'], ['G07.345.500.325', 'G08.686.784.170'], ['G05.360.340.024.340.137.232'], ['G05.308.320'], ['G05.360.340.024.340.435'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['D06.472.699.584.750', 'D12.644.548... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nanoparticle reinforced bacterial outer-membrane vesicles effectively prevent fatal infection of carbapenem-resistant Klebsiella pneumoniae. | Infection resulting from carbapenem-resistant Klebsiella pneumoniae (CRKP) is an intractable clinical problem. Outer membrane vesicles (OMVs) from CRKP are believed to be potential vaccine candidates. However, their immune response remains elusive due to low structural stability and poor size homogeneity. In this study... | ['Albumins', 'Animals', 'Bacterial Outer Membrane', 'Carbapenems', 'Cell Line', 'Dendritic Cells', 'Drug Resistance, Bacterial', 'Extracellular Vesicles', 'Hydrodynamics', 'Klebsiella pneumoniae', 'Mice', 'Microscopy, Electron, Transmission', 'Nanoparticles', 'RAW 264.7 Cells'] | 31,887,427 | [['D12.776.034'], ['B01.050'], ['A11.284.149.083', 'A20.484'], ['D02.065.589.099.124', 'D03.633.100.300.124'], ['A11.251.210'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['A11.284.295.588'], ['G01.342'], ['B03.440.450.425.425.600', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Inhaled corticosteroids in chronic obstructive pulmonary disease: new trials and old practices. | The practice of using inhaled steroids (ICS) in chronic obstructive pulmonary disease (COPD) is common but controversial. Four large randomized controlled trials provide an objective assessment of this practice. An examination of the design of these studies is useful to explaining some of the differences between their ... | ['Budesonide', 'Forced Expiratory Volume', 'Glucocorticoids', 'Humans', 'Pulmonary Disease, Chronic Obstructive', 'Randomized Controlled Trials as Topic', 'Spirometry', 'Treatment Outcome'] | 12,737,679 | [['D04.210.500.745.745.654.105'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.495.389'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500', 'N06.850.520.450.250.250.365.500'], ['E01.370.386.700... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Phase II Study of Modified Carboplatin Plus Weekly Nab-Paclitaxel in Elderly Patients with Non-Small Cell Lung Cancer: North Japan Lung Cancer Study Group Trial 1301. | LESSONS LEARNED: Weekly nanoparticle albumin-bound-paclitaxel (75 mg/m2) in combination with carboplatin (area under the curve 6 mg/mL/min) in elderly patients with previously untreated, advanced non-small cell lung cancer showed favorable efficacy, was well tolerated, and showed less neuropathic toxicity.This modified... | ['Aged', 'Aged, 80 and over', 'Albumins', 'Antineoplastic Combined Chemotherapy Protocols', 'Carboplatin', 'Carcinoma, Non-Small-Cell Lung', 'Disease-Free Survival', 'Drug-Related Side Effects and Adverse Reactions', 'Female', 'Humans', 'Japan', 'Male', 'Paclitaxel', 'Treatment Outcome'] | 28,526,722 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.034'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D02.257.125'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.80... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Synergistic cytotoxic effects of tamoxifen and black cohosh on MCF-7 and MDA-MB-231 human breast cancer cells: an in vitro study. | Breast cancer cell cultures were exposed to different concentrations of black cohosh, estradiol (E2), and tamoxifen to examine the effect on cell proliferation; cytotoxicity was assessed by using sulforhodamine B (SRB) dye solution. E2 (10(-10) - 10(-8) mol/L) markedly stimulated the proliferation of MCF-7 cells (p < 0... | ['Breast Neoplasms', 'Cell Line, Tumor', 'Cell Proliferation', 'Cimicifuga', 'Dose-Response Relationship, Drug', 'Drug Synergism', 'Estradiol', 'Humans', 'Phytotherapy', 'Tamoxifen'] | 18,066,117 | [['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['B01.650.940.800.575.912.250.836.750.182'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.968.477'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.988.400.112... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Extent of nasopharyngeal carcinoma involvement inside the nasopharynx. Lack of prognostic value on local control. | A study on the use of fiberscopic examination and multiple biopsy specimens taken from the nasopharynx in the assessment of the extent of nasopharyngeal carcinoma (NPC) involvement inside the nasopharynx found that the involvement often was more extensive than the detected with conventional methods. In the current stud... | ['Actuarial Analysis', 'Endoscopy', 'Fiber Optic Technology', 'Humans', 'Lymphatic Metastasis', 'Nasopharyngeal Neoplasms', 'Nasopharynx', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Prognosis', 'Prospective Studies'] | 1,735,076 | [['E05.318.740.100', 'N05.715.360.750.100', 'N06.850.520.830.100'], ['E01.370.388.250', 'E04.502.250'], ['H01.671.617.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['C04.588.443.665.710.650', 'C07.550.350.650', 'C07.550.745.650', 'C09.647.710.650', 'C09.775.350.650'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
The effect of interactions on the cellular uptake of nanoparticles. | We present a simple two-state model to understand the size-dependent endocytosis of nanoparticles. Using this model, we elucidate the relevant energy terms required to understand the size-dependent uptake mechanism and verify it by correctly predicting the behavior at large and small particle sizes. In the absence of i... | ['Endocytosis', 'Models, Biological', 'Models, Statistical', 'Nanoparticles', 'Particle Size', 'Thermodynamics'] | 21,508,440 | [['G04.417'], ['E05.599.395'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['J01.637.512.600'], ['G02.712'], ['G01.906']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Complex cystine kidney stones treated with combined robot-assisted laparoscopic pyelolithotomy and intraoperative renoscopy. | INTRODUCTION: Cystinuria, a rare autosomal recessive disease characterized by a defect in cystine renal reabsorption, can often determine complex cystine renal calculi, leading to important complications such as urinary obstruction, urinary infections, and impaired kidney function. Complex kidney stones can have a diff... | ['Combined Modality Therapy', 'Cystine', 'Endoscopy', 'Female', 'Humans', 'Intraoperative Care', 'Kidney Calculi', 'Laparoscopy', 'Nephrotomy', 'Robotic Surgical Procedures', 'Young Adult'] | 28,222,205 | [['E02.186'], ['D01.248.497.158.874.390.369', 'D01.875.350.850.150.369', 'D02.886.030.230.369', 'D02.886.520.150.087', 'D12.125.095.369', 'D12.125.119.369', 'D12.125.166.230.369'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.731.400', 'E04.604.249', 'N02.421.585.722.40... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Peroxisome proliferator-activated receptor gamma, coactivator 1á enhances local estrogen biosynthesis by stimulating aromatase activity in endometriosis. | CONTEXT: Endometriosis is an estrogen-dependent disease, and estrogen is overproduced by abnormally elevated aromatase in endometriotic tissues. Peroxisome proliferator-activated receptor gamma, coactivator 1á (PGC-1á) is a transcriptional coactivator-modulating steroid hormone.OBJECTIVE: To investigate the effect of P... | ['Adult', 'Aromatase', 'Cells, Cultured', 'Endometriosis', 'Endometrium', 'Estradiol', 'Female', 'Gene Expression Regulation', 'Humans', 'Middle Aged', 'Ovarian Diseases', 'Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha', 'Promoter Regions, Genetic', 'Transcription Factors', 'Up-Regulation'] | 24,654,751 | [['M01.060.116'], ['D08.244.453.489.500', 'D08.244.453.915.099', 'D08.811.682.690.708.170.447.500', 'D08.811.682.690.708.170.915.099', 'D12.776.422.220.453.489.500', 'D12.776.422.220.453.915.099'], ['A11.251'], ['C13.351.500.163'], ['A05.360.319.679.490'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['G05.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Edentulation alters material properties of cortical bone in the human mandible. | Ridge resorption following edentulation has been documented clinically, but the effects of tooth loss on the material properties of mandibular cortical bone have received little study. Material properties and their structural basis are essential for our understanding of bone quality in the edentulous mandible and are o... | ['Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Biomechanical Phenomena', 'Bone Density', 'Bone Resorption', 'Cadaver', 'Elasticity', 'Female', 'Humans', 'Jaw, Edentulous', 'Male', 'Mandible', 'Middle Aged', 'Poisson Distribution', 'Signal Processing, Computer-Assisted', 'Statistics as Topic', 'Stress, Mechanica... | 12,202,642 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['G01.154.090', 'G01.374.089'], ['G11.427.100'], ['C05.116.264', 'G11.427.213.150'], ['C23.550.260.224'], ['G01.374.590'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.500.480', 'C07.320.550', 'C0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Ventricular substrate identification using close-coupled paced electrogram feature analysis. | AIMS: Substrate based catheter ablation strategies are widely employed for treatment of scar-related ventricular tachycardia (VT). We analysed intracardiac electrograms (EGMs) from close-coupled paced extrastimuli extracted from the EnSite Precision mapping system. We sought to characterize EGM responses of ventricular... | ['Action Potentials', 'Aged', 'Cardiac Pacing, Artificial', 'Case-Control Studies', 'Catheter Ablation', 'Electrophysiologic Techniques, Cardiac', 'Female', 'Heart Rate', 'Heart Ventricles', 'Humans', 'Male', 'Predictive Value of Tests', 'Refractory Period, Electrophysiological', 'Tachycardia, Ventricular', 'Time Facto... | 30,481,301 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['M01.060.116.100'], ['E02.331.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E02.808.750.500', 'E04.014.760.500'], ['E01.370.370.380.245', 'E01.370.405.267'], ['E01.370.600.875.500', 'G09.330.380.500'], ['A07.541.560'], ['... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Production, characterization and control of a Neisseria meningitidis hexavalent class 1 outer membrane protein containing vesicle vaccine. | An experimental serogroup B meningococcal vaccine was prepared from two genetically engineered strains; each expressing three different class 1 outer membrane proteins (OMPs) (PorA). The two strains expressed the subtypes P1.7,16;P1.5,2;P1.19,15 and P1.5c,10;P1.12,13;P1.7h,4, respectively. Outer membrane vesicles (OMV)... | ['Animals', 'Bacterial Outer Membrane Proteins', 'Bacterial Vaccines', 'Female', 'Humans', 'Meningitis, Meningococcal', 'Mice', 'Microscopy, Electron', 'Neisseria meningitidis'] | 8,873,395 | [['B01.050'], ['D12.776.097.120', 'D12.776.543.100'], ['D20.215.894.135'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.150.252.223.500.750', 'C01.150.252.400.625.549.449', 'C01.207.180.500.750', 'C10.228.228.180.500.750', 'C10.228.614.280.505'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.350.515.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine. | 2',2'-Difluorodeoxycytidine (dFdC) is a new deoxycytidine analogue with good activity against human leukemic cell lines and murine solid tumors, while the activity of 1-beta-D-arabinofuranosylcytosine (ara-C) is established in experimental systems and for the treatment of human adult leukemia. This study compared the c... | ['Animals', 'Arabinofuranosylcytosine Triphosphate', 'Cell Line', 'Cell Survival', 'Clone Cells', 'Cytarabine', 'DNA Replication', 'Deoxycytidine', 'Deoxycytidine Kinase', 'Drug Evaluation, Preclinical', 'Kinetics'] | 3,383,195 | [['B01.050'], ['D03.383.742.686.246.050', 'D13.695.065.200', 'D13.695.740.246.050'], ['A11.251.210'], ['G04.346'], ['A11.251.353'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['G02.111.225', 'G05.226'], ['D03.383.742.680.245.500', 'D13.570.230.329', 'D13.570.685.245.500'], ['D08.811.913.696.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A sacred command of reason? Deceit, deception, and dishonesty in nurse education. | Kant (Grounding for the Metaphysics of Morals. Hackett, Indianapolis, 1797) described honesty as 'a sacred command of reason' which should be obeyed at all times and at any cost. This study inquires into the practice of dishonesty, deception, and deceit by universities in the UK in the pursuit of quality indicators suc... | ['Deception', 'Education, Nursing', 'Ethics, Professional', 'Humans', 'Quality Indicators, Health Care', 'United Kingdom', 'Universities'] | 27,222,358 | [['F01.145.813.157'], ['I02.358.462'], ['K01.752.566.479.171', 'N05.350.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.789', 'N05.715.760'], ['Z01.542.363'], ['I02.783.830', 'J03.832.830']] | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Hiatus hernia in healthy volunteers is associated with intrasphincteric reflux and cardiac mucosal lengthening without traditional reflux. | BACKGROUND AND AIMS: Hiatus hernia (HH) is a key mediator of gastro-oesophageal reflux disease but little is known about its significance in the general population. We studied the structure and function of the gastro-oesophageal junction in healthy volunteers with and without HH.METHODS: We compared 15 volunteers with ... | ['Adult', 'Aged', 'Biopsy', 'Cardia', 'Case-Control Studies', 'Endoscopy, Gastrointestinal', 'Esophageal Sphincter, Lower', 'Esophagogastric Junction', 'Female', 'Fluoroscopy', 'Gastric Acidity Determination', 'Gastroesophageal Reflux', 'Healthy Volunteers', 'Hernia, Hiatal', 'Humans', 'Magnetic Resonance Imaging', 'Ma... | 27,196,581 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A03.556.875.875.163'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.372.250.250', 'E01.370.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Correlations of laboratory and instrumental method parameters in the diagnosis of acute ischemic lesion of the myocardium]. | The detection rate was examined for ECG (EchoECG) equivalents of clinical coronary heart disease (CHD) forms, such as angina pectoris, focal myocardial dystrophy, small and large myocardial infarction, at various levels of the peak activity of blood creatine phosphokinase in the acute period of the disease. A series of... | ['Aged', 'Angina Pectoris', 'Clinical Enzyme Tests', 'Coronary Disease', 'Creatine Kinase', 'Diagnosis, Differential', 'Echocardiography', 'Electrocardiography', 'Female', 'Humans', 'Isoenzymes', 'L-Lactate Dehydrogenase', 'Male', 'Myocardial Infarction', 'Myoglobin'] | 2,290,268 | [['M01.060.116.100'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['E01.370.225.124.200', 'E05.196.427.200', 'E05.200.124.200'], ['C14.280.647.250', 'C14.907.585.250'], ['D08.811.913.696.640.150'], ['E01.171'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E01.370.370.3... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Electrochemical detection of catecholamine release from rat carotid body in vitro. | Neurotransmitter secretion from carotid body glomus cells is hypothesized to be an essential element of chemotransduction. To address one aspect of this hypothesis, catecholamine release in response to hypoxic hypoxia and histotoxic hypoxia was examined using electrically treated carbon-fiber microelectrodes placed in ... | ['Action Potentials', 'Animals', 'Carotid Body', 'Catecholamines', 'Chemoreceptor Cells', 'Cyanides', 'Electrochemistry', 'Hypoxia', 'In Vitro Techniques', 'Microelectrodes', 'Neurons', 'Oxidation-Reduction', 'Rats', 'Stimulation, Chemical'] | 8,335,564 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['A08.675.650.915.500.600.150', 'A08.800.950.500.600.150', 'A11.671.650.915.500.600.150'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['A08.675.650.915.500', 'A08.800.950.500', 'A11.671.650.915.500'], ['D01.248.497.158.291', 'D01.625.400.100'... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-term mortality and pacing outcomes of patients with permanent pacemaker implantation after cardiac surgery. | BACKGROUND: Approximately 20,000 permanent pacemakers (PPMs) are implanted annually for bradycardia or atrioventricular (AV) block after cardiac surgery. Little is known about the long-term pacing and mortality outcomes and the temporal trends of these patients.METHODS: We examined 6,268 consecutive patients who underw... | ['Aged', 'Cardiac Pacing, Artificial', 'Cardiovascular Surgical Procedures', 'Combined Modality Therapy', 'Equipment Safety', 'Female', 'Humans', 'Italy', 'Longitudinal Studies', 'Male', 'Pacemaker, Artificial', 'Prevalence', 'Prosthesis Implantation', 'Risk Assessment', 'Risk Factors', 'Survival Analysis', 'Survival R... | 21,208,223 | [['M01.060.116.100'], ['E02.331.200'], ['E04.100'], ['E02.186'], ['E05.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['E07.305.250.750'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A hydrophilic polymer grafted with a histone tail peptide as an artificial gene regulator. | In chromatin, gene transcription is regulated through posttranslational modifications on the histone N-terminal tail sequences, typically an acetyl group modification on lysine residues. To realize a simple model of the gene regulation of chromatin, we designed a hydrophilic polymer grafted with histone H3 tail peptide... | ['Acetylation', 'Animals', 'Chromatin', 'DNA', 'Fireflies', 'Gene Expression Regulation', 'Histone Acetyltransferases', 'Histones', 'Humans', 'Hydrophobic and Hydrophilic Interactions', 'Luciferases, Firefly', 'Polylysine', 'Polymers', 'Protein Binding'] | 21,636,282 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['B01.050'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['D13.444.308'], ['B01.050.500.131.617.720.500.500.375.307'], ['G05.308'], ['D08.811.913.050.134.415.500'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The expression of p63 and p53 in keratoacanthoma and intraepidermal and invasive neoplasms of the skin. | p53 is a well-known tumor suppressor gene, and its mutation is a common event in intraepidermal and invasive neoplasms of the skin. p63 is a homologue of the tumor suppressor gene p53, which is expressed in human basal squamous epithelium, and despite its homology to p53, it is considered to act as an oncogene. We eval... | ['Biomarkers, Tumor', 'Carcinoma, Basal Cell', 'Carcinoma, Squamous Cell', 'Diagnosis, Differential', 'Humans', 'Immunohistochemistry', 'Keratoacanthoma', 'Keratosis, Actinic', 'Melanoma', 'Membrane Proteins', 'Paget Disease, Extramammary', 'Precancerous Conditions', 'Skin Diseases', 'Skin Neoplasms', 'Tumor Suppressor... | 19,577,853 | [['D23.101.140'], ['C04.557.470.200.165', 'C04.557.470.565.165'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', '... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Structure of the serotype f polysaccharide antigen of Streptococcus mutans. | The structure of the serotype f polysaccharide antigen of Streptococcus mutans was determined by methylation analysis, periodate oxidation, and partial methanolysis, and the configuration of the anomeric linkages by 13C-n.m.r. spectroscopy, indicating the trisaccharide repeating unit----3)-alpha-L-Rhap-(1----2)-[alpha-... | ['Carbohydrate Conformation', 'Carbohydrate Sequence', 'Indicators and Reagents', 'Magnetic Resonance Spectroscopy', 'Polysaccharides, Bacterial', 'Serotyping', 'Streptococcus mutans'] | 3,652,074 | [['G02.111.570.820.235'], ['G02.111.570.160', 'L01.453.245.667.160'], ['D27.720.470.410'], ['E05.196.867.519'], ['D09.698.718', 'D23.050.161.616'], ['E01.370.225.812.742', 'E01.370.225.875.150.125.890', 'E05.200.812.742', 'E05.200.875.150.125.890', 'E05.478.594.780'], ['B03.353.750.737.872.875.520', 'B03.510.400.800.87... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
S.E.M. study of urease-induced crystalluria in the presence of hydroxamic derivatives. | The effect of 3 hydroxamic acid derivatives on urease-induced crystalluria was studied in vitro. Acetohydroxamic acid is more effective than salicylhydroxamic and gentisohydroxamic acids in inhibiting the kinetic of urease enzymatic reaction and in retarding the formation of struvite and apatite. Crystal deposits studi... | ['Apatites', 'Calcium', 'Crystallization', 'Humans', 'Hydroxamic Acids', 'Kinetics', 'Magnesium', 'Magnesium Compounds', 'Microscopy, Electron, Scanning', 'Phosphates', 'Phosphorus', 'Salicylamides', 'Struvite', 'Urease', 'Urinary Calculi'] | 3,771,124 | [['D01.029.260.700.675.374.075.025', 'D01.146.360.050', 'D01.578.122', 'D01.695.625.675.650.075.025'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E05.196.300', 'G02.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.092.570.394', 'D02.241.511.372'], ['G01.374.661', 'G02.111.490'], ['D01.268.552... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasmic domain of E-selectin contains a non-tyrosine endocytosis signal. | E-selectin is an activation-dependent, endothelial cell-restricted adhesion molecule that is internalized and degraded rapidly once expressed on the cell surface. Tyrosine-containing structural motifs play an important role in the internalization of a number of integral proteins, and the membrane-proximal E-selectin cy... | ['Amino Acid Sequence', 'Animals', 'CHO Cells', 'Cell Membrane', 'Consensus Sequence', 'Cricetinae', 'Cytoplasm', 'E-Selectin', 'Endocytosis', 'Humans', 'Kinetics', 'Mice', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Rats', 'Recombinant Proteins', 'Sequence Alignment', 'Signal Transduction', 'Swine', 'Tra... | 9,312,078 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.251.210.200', 'A11.436.155'], ['A11.284.149'], ['G02.111.570.580.175'], ['B01.050.150.900.649.313.992.635.075.250'], ['A11.284.430.214'], ['D12.776.395.550.200.700.300', 'D12.776.503.843.300', 'D12.776.543.550.200.700.300', 'D23.050.301.350.700.300'], ['G0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Respiration and sleep in Parkinson's disease. | Sleep and respiration during sleep were studied in patients with idiopathic Parkinson's disease, patients with Parkinsonism with autonomic disturbance, and normal age and sex matched controls. Patients with idiopathic Parkinson's disease showed significantly reduced REM sleep, and more frequent and prolonged waking thr... | ['Adult', 'Aged', 'Airway Obstruction', 'Autonomic Nervous System Diseases', 'Female', 'Humans', 'Male', 'Middle Aged', 'Oxygen', 'Parkinson Disease', 'Respiration Disorders', 'Shy-Drager Syndrome', 'Sleep Apnea Syndromes', 'Sleep Initiation and Maintenance Disorders', 'Sleep Wake Disorders', 'Sleep, REM'] | 4,086,999 | [['M01.060.116'], ['M01.060.116.100'], ['C08.618.846.185'], ['C10.177'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D01.268.185.550', 'D01.362.670'], ['C10.228.140.079.862.500', 'C10.228.662.600.400', 'C10.574.928.750'], ['C08.618'], ['C10.177.575.550.750', 'C10.228.140.079.612.700', 'C10.2... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Transmission of Streptococcus pneumoniae in rural Gambian villages: a longitudinal study. | BACKGROUND. To prepare for national introduction of a pneumococcal vaccine of restricted valency, we studied the pattern of nasopharyngeal carriage of Streptococcus pneumoniae and its transmission in Gambian villages over time. METHODS. We collected nasopharyngeal swab specimens every 2 weeks from 158 villagers in 19 h... | ['Adolescent', 'Adult', 'Bacterial Typing Techniques', 'Carrier State', 'Child', 'Child, Preschool', 'Cluster Analysis', 'DNA Fingerprinting', 'Family Health', 'Female', 'Gambia', 'Genotype', 'Humans', 'Infant', 'Infant, Newborn', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Nasopharynx', 'Pneumococcal Infections', ... | 20,420,503 | [['M01.060.057'], ['M01.060.116'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['N06.850.520.169'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['N01.400.300'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effects of intraocular dapiprazole in the rabbit eye. | Dapiprazole produces miosis by blocking the alpha 1 receptors in the radial muscle of the iris; its intraocular effect has not yet been investigated. In this preliminary experimental animal study, we investigated the intracameral use of 0.2 ml of 0.005%, 0.0075%, 0.01%, and 0.05% dapiprazole to reverse mydriasis by 10%... | ['Animals', 'Anterior Chamber', 'Aqueous Humor', 'Dose-Response Relationship, Drug', 'Endothelium, Corneal', 'Female', 'Male', 'Phenylephrine', 'Piperazines', 'Pupil', 'Rabbits', 'Triazoles', 'Tropicamide'] | 2,614,713 | [['B01.050'], ['A09.371.060.067'], ['A09.371.060.067.070', 'A12.207.270.040'], ['G07.690.773.875', 'G07.690.936.500'], ['A09.371.060.067.318', 'A09.371.060.217.318', 'A10.272.491.318'], ['D02.033.100.291.617', 'D02.092.063.291.617'], ['D03.383.606'], ['A09.371.060.450.780', 'A09.371.894.513.780'], ['B01.050.150.900.649... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Visualization of layers lining the lung of the South American lungfish (Lepidosiren paradoxa) and a comparison with the frog and rat. | Comarisons have been made of the structure of layers lining the lungs of lungfish, frog and rat using material fixed by perfusion of the pulmonary circulation of physiological pressures and at normal air pressures within the lung. The lining consists of a thin densely osmiophilic surface layer which covers a much thick... | ['Animals', 'Anura', 'Capillaries', 'Cell Membrane', 'Endothelium', 'Epithelium', 'Fishes', 'Lung', 'Pulmonary Alveoli', 'Pulmonary Surfactants', 'Rana esculenta', 'Rats'] | 307,841 | [['B01.050'], ['B01.050.150.900.090.180'], ['A07.015.461.165'], ['A11.284.149'], ['A10.272.491'], ['A10.272'], ['B01.050.150.900.493'], ['A04.411'], ['A04.411.715'], ['D27.505.954.796.600'], ['B01.050.150.900.090.180.708.240'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Active variants of human parathyroid hormone (1-34) with multiple amino acid substitutions. | We used site-directed mutagenesis to construct 55 single-site variants of rhPTH, a recombinantly-expressed form of human parathyroid hormone (1-34) containing three amino acid changes compared to the natural sequence (ML8, ML18 and FY34). We identified several mutations, at residues Lys(13), Glu(19), Val(21), Glu(22), ... | ['Amino Acid Sequence', 'Amino Acid Substitution', 'Animals', 'Base Sequence', 'Cell Line', 'DNA, Recombinant', 'Genetic Variation', 'Humans', 'Kinetics', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Parathyroid Hormone', 'Peptide Fragments', 'Plasmids', 'Rats', 'Receptors, Parathyroid Hormone', 'Recombina... | 10,715,547 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['D13.444.308.460'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['L01.453.245.667'], ['E05.393.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Skin changes and lesions in our senior citizens: incidences. | One hundred and sixty-three community volunteers were interviewed and examined. After a decade, the 69 survivors were again interviewed and examined. The incidences of their skin changes and lesions were recorded and interrelationships sought relative to internal and external signs of aging. Asteatosis of moderate or s... | ['African Continental Ancestry Group', 'Aged', 'Aging', 'European Continental Ancestry Group', 'Female', 'Follow-Up Studies', 'Hair', 'Humans', 'Longevity', 'Male', 'Skin', 'Skin Diseases'] | 1,017,303 | [['M01.686.508.100'], ['M01.060.116.100'], ['G07.345.124'], ['M01.686.508.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A17.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.345.124.519', 'G07.540'], ['A17.815'], ['C17.800']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evaluation of insulin sensitivity in hyperprolactinemic subjects by euglycemic hyperinsulinemic clamp technique. | The background and aim of the study is to evaluate insulin sensitivity in hyperprolactinemic subjects via euglycemic hyperinsulinemic clamp technique. Sixteen hyperprolactinemic subjects and 12 healthy subjects were included in the study. HOMA-B and HOMA-IR values of groups were calculated. Euglycemic hyperinsulinemic ... | ['Adult', 'Blood Glucose', 'Female', 'Glucose Clamp Technique', 'Humans', 'Hyperprolactinemia', 'Immunoassay', 'Insulin Resistance', 'Lipids', 'Male', 'Prolactin', 'Reference Values', 'Young Adult'] | 19,408,128 | [['M01.060.116'], ['D09.947.875.359.448.500'], ['E01.370.225.124.100.350', 'E05.196.500', 'E05.200.124.100.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.617.738.250.450', 'C19.700.355.600'], ['E05.478.566', 'E05.601.470'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['D10'], ['D06.472.699.32... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Studies on the optimal conditions for inactivation of Bordetella pertussis organisms with glutaraldehyde for preparation of a safe and potent pertussis vaccine. | The optimal conditions for inactivation of Bordetella pertussis organisms with glutaraldehyde for the production of a safe and potent whole cell pertussis vaccine were investigated. Two bacterial harvests from B. pertussis strain 10536 were treated with glutaraldehyde, each with 0.025, 0.05 and 0.1% concentrations of g... | ['Aldehydes', 'Animals', 'Biomarkers', 'Bordetella pertussis', 'Glutaral', 'Histamine', 'Hot Temperature', 'Mice', 'Pertussis Vaccine', 'Vaccines, Inactivated', 'Weight Gain'] | 2,907,704 | [['D02.047'], ['B01.050'], ['D23.101'], ['B03.440.400.425.115.425.600', 'B03.660.075.090.344.425.600'], ['D02.047.532'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Comparative evaluation of corpus callosum DTI metrics in acute mild and moderate traumatic brain injury: its correlation with neuropsychometric tests. | PRIMARY OBJECTIVE: To look for differences in vulnerability of corpus callosum (CC) in patients of mild and moderate traumatic brain injury (TBI) in the acute stage using quantitative diffusion tensor imaging (DTI) and to correlate these with neuropsychometric tests (NPT) done at 6 months post-injury. RESEARCH DESIGN, ... | ['Adolescent', 'Adult', 'Brain Injuries', 'Corpus Callosum', 'Diffusion Magnetic Resonance Imaging', 'Diffusion Tensor Imaging', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nerve Fibers', 'Neuropsychological Tests', 'Reference Values', 'Young Adult'] | 19,557,571 | [['M01.060.057'], ['M01.060.116'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['A08.186.211.200.885.800.750'], ['E01.370.350.825.500.150'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Upper-limb pain in long-term poliomyelitis. | BACKGROUND: Late functional deterioration is common in long-term poliomyelitis patients. While upper-limb pain in individual functional regions is common, its overall prevalence and pattern in long-term poliomyelitis is poorly documented.AIM: To assess the nature of upper-limb pain in these patients and examine its ass... | ['Adult', 'Aged', 'Aged, 80 and over', 'Arm', 'Canes', 'Cross-Sectional Studies', 'Crutches', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pain', 'Poliomyelitis', 'Wheelchairs'] | 12,037,247 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A01.378.800.075'], ['E07.858.442.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E07.858.442.281'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.888.592.612', 'F02.830.816.444', 'G11.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Proteomic analysis of the major birch allergen Bet v 1 predicts allergenicity for 15 birch species. | Pollen of the European and Asian white birch (Betula pendula and B. platyphylla) causes hay fever in humans. The allergenic potency of other birch species is largely unknown. To identify birch trees with a reduced allergenicity, we assessed the immunochemical characteristics of 15 species and two hybrids, representing ... | ['Allergens', 'Amino Acid Sequence', 'Antigens, Plant', 'Betula', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'Molecular Sequence Data', 'Protein Isoforms', 'Proteomics'] | 21,459,169 | [['D23.050.063'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D23.050.291'], ['B01.650.940.800.575.912.250.859.750.200.750'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['D12.776.800'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.3... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Deepithelialized turnover flaps in burns. | Acute and chronic burns leave behind a full-thickness defect that always requires a flap cover. Such defects are common in electrical burn injuries of the limbs. This paper deals with 35 patients with full-thickness defects following burns in whom deepithelialized turnover dermis flaps and deepithelialized turnover fla... | ['Arm Injuries', 'Burns, Electric', 'Humans', 'Leg Injuries', 'Methods', 'Surgical Flaps'] | 3,254,694 | [['C26.088'], ['C26.200.239', 'C26.324.323'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.558'], ['E05.581'], ['A10.850.710', 'E07.862.710']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tungsten-catalyzed regio- and enantioselective aminolysis of trans-2,3-epoxy alcohols: an entry to virtually enantiopure amino alcohols. | The first catalytic enantioselective aminolysis of trans-2,3-epoxy alcohols has been accomplished. This stereospecific ring-opening process was efficiently promoted by a tungsten/bis(hydroxamic acid) catalytic system, furnishing various anti-3-amino-1,2-diols with excellent regiocontrol and high enantioselectivities (u... | ['Amino Alcohols', 'Catalysis', 'Tungsten'] | 25,328,028 | [['D02.033.100', 'D02.092.063'], ['G02.130'], ['D01.268.556.887', 'D01.268.956.882', 'D01.552.544.887']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Psychometric assessment of mental health in tinnitus patients, depressive and healthy controls. | Tinnitus describes the perception of a sound without external source and is characterized by high comorbidity, e.g. depression. In many studies, tinnitus patients were compared to healthy controls while a comorbid psychiatric diagnosis was an exclusion criterion. Consequently, patients with severe tinnitus and psychiat... | ['Adult', 'Aged', 'Depressive Disorder, Major', 'Female', 'Healthy Volunteers', 'Humans', 'Male', 'Mental Health', 'Middle Aged', 'Psychometrics', 'Surveys and Questionnaires', 'Tinnitus', 'Young Adult'] | 31,586,842 | [['M01.060.116'], ['M01.060.116.100'], ['F03.600.300.375'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.418', 'N01.400.500'], ['M01.060.116.630'], ['F04.711.780'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['C09.218.458.670', 'C10.597.751.418.670', 'C2... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase. | Sepsis may be modeled using lipopolysaccharide (LPS), which alters levels of nitric oxide (NO), synthesized via endothelial and inducible nitric oxide synthase (eNOS and iNOS). This study aimed to determine whether the Rho kinase (ROCK) inhibitor fasudil protected against LPS-induced (endotoxemia) macromolecular leak a... | ['1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine', 'Animals', 'Blood Pressure', 'Capillary Permeability', 'Cell Adhesion', 'Endothelial Cells', 'Endotoxemia', 'Inflammation', 'Leukocytes', 'Lipopolysaccharides', 'Male', 'Microcirculation', 'Microvessels', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Nitric Oxide Synthase T... | 21,354,186 | [['D02.886.590.700.545', 'D03.383.606.527', 'D03.633.100.531.400'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G03.143.330', 'G09.330.165'], ['G04.022'], ['A11.436.275'], ['C01.757.100.275', 'C01.861.375', 'C23.550.470.790.500.100.275'], ['C23.550.470'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of electrical stimulation of the inferior central raphe nucleus on spontaneous and induced thalamic neuron activity in awake cats]. | Using microelectrode technique in chronic experiments it was shown that electrical stimulation of the inferior raphe nucleus inhibited spontaneous activity of the thalamic neurons and that evoked by stimulation of radial nerves. Changes in the activity of the same neurons were absent in case of stimulation of the bulba... | ['Animals', 'Brain Stem', 'Cats', 'Electric Stimulation', 'Evoked Potentials', 'Pain', 'Radial Nerve', 'Raphe Nuclei', 'Thalamic Nuclei'] | 656,571 | [['B01.050'], ['A08.186.211.132'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.723.402'], ['G07.265.216.500', 'G11.561.200.500'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['A08.800.800.720.050.700'], ['A08.186.211.132.659.413.875.618', 'A08.186.211.132.810.428.600.650.562', 'A08.186.211.132... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Late Middle Eocene primate from Myanmar and the initial anthropoid colonization of Africa. | Reconstructing the origin and early evolutionary history of anthropoid primates (monkeys, apes, and humans) is a current focus of paleoprimatology. Although earlier hypotheses frequently supported an African origin for anthropoids, recent discoveries of older and phylogenetically more basal fossils in China and Myanmar... | ['Africa', 'Animals', 'Hominidae', 'Myanmar', 'Phylogeny', 'Primates'] | 22,665,790 | [['Z01.058'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.400'], ['Z01.252.145.570'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B01.050.150.900.649.313.988']] | ['Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
[Detection of pulmonary embolisms by recording of the variations of thoracic impedance at each lung]. | It is possible to record changes of volume caused by variations of the blood supply to each lung by measuring the transthoracic electrical impedance. A theoretical study was performed beforehand to define the variations of the impedance of the deep-lying structures. The form, number and distribution of the electrodes w... | ['Adult', 'Aged', 'Cardiography, Impedance', 'Electrocardiography', 'Female', 'Humans', 'Male', 'Methods', 'Middle Aged', 'Phonocardiography', 'Pulmonary Embolism'] | 112,936 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Possible interaction between myxomatosis and calicivirosis related to rabbit haemorrhagic disease affecting the European rabbit. | Serological data on myxoma virus, rabbit haemorrhagic disease (RHD) virus and RHD-like viruses in juvenile rabbits (Oryctolagus cuniculus) trapped in 1995, 1996 and 1997 in two areas of France were analysed. For each disease, the effects of bodyweight, year, month and seropositivity for the other disease were modelled ... | ['Animals', 'Antibodies, Viral', 'Body Weight', 'Caliciviridae Infections', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'France', 'Hemorrhagic Disease Virus, Rabbit', 'Logistic Models', 'Male', 'Myxoma virus', 'Myxomatosis, Infectious', 'Rabbits', 'Seroepidemiologic Studies', 'Viral Structural Proteins'] | 15,573,951 | [['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C01.925.782.160'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Expression of breast cancer specific gene-1 (BCSG-1/gamma-synuclein) is associated with tumour grade but not with clinical outcome of patients with breast cancer. | This study examined the expression and distribution of BCSG-1 in human breast cancer tissue. IHC revealed that BCSG-1 was primarily seen as a cytosolic protein, weakly staining normal mammary epithelial cells but increased in breast tumour cells. Q-PCR revealed that node negative and positive tumours had similar levels... | ['Breast Neoplasms', 'DNA Primers', 'Disease-Free Survival', 'Female', 'Follow-Up Studies', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Neoplasm Metastasis', 'Prognosis', 'RNA, Messenger', 'Time Factors', 'Transglutaminases', 'Treatment Outcome', 'gamma-Synuclein'] | 16,786,148 | [['C04.588.180', 'C17.800.090.500'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Examining the association between emotion regulation difficulties and probable posttraumatic stress disorder within a sample of African Americans. | This study examined the associations between emotion dysregulation and probable posttraumatic stress disorder (PTSD) among 180 African American undergraduates enrolled in a historically black college in the southern United States. Trauma-exposed participants with probable PTSD reported significantly higher levels of ov... | ['Adult', 'Affective Symptoms', 'African Americans', 'Aged', 'Female', 'Humans', 'Life Change Events', 'Male', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Self Report', 'Stress Disorders, Post-Traumatic'] | 22,074,329 | [['M01.060.116'], ['F01.145.126.100'], ['M01.686.508.100.100', 'M01.686.754.100'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458.410'], ['M01.060.116.630'], ['F04.711.513.653'], ['E05.318.308.980.500', 'N05.715.360.300.800.500', 'N06.850.520.308.980.500'], ['F03.950.750.500']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Brain electric correlates of strong belief in paranormal phenomena: intracerebral EEG source and regional Omega complexity analyses. | The neurocognitive processes underlying the formation and maintenance of paranormal beliefs are important for understanding schizotypal ideation. Behavioral studies indicated that both schizotypal and paranormal ideation are based on an overreliance on the right hemisphere, whose coarse rather than focussed semantic pr... | ['Adult', 'Brain Mapping', 'Cerebral Cortex', 'Dominance, Cerebral', 'Electroencephalography', 'Evoked Potentials', 'Female', 'Fourier Analysis', 'Humans', 'Male', 'Parapsychology', 'Schizotypal Personality Disorder', 'Signal Processing, Computer-Assisted'] | 11,120,441 | [['M01.060.116'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['F02.830.297', 'G11.561.225'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500', 'G11.561.200.500'], ['E05.377', 'G17.226', 'L01.224.800.625'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Linguistic and Cultural Challenges in Communication and Translation in US-Sponsored HIV Prevention Research in Emerging Economies. | Linguistic and cultural differences can impede comprehension among potential research participants during the informed consent process, but how researchers and IRBs respond to these challenges in practice is unclear. We conducted in-depth interviews with 15 researchers, research ethics committee (REC) chairs and member... | ['Communication', 'Consent Forms', 'Cultural Characteristics', 'Developing Countries', 'Ethics Committees, Research', 'Ethics, Research', 'Female', 'HIV Infections', 'Humans', 'Informed Consent', 'Linguistics', 'Male', 'Translations'] | 26,225,759 | [['F01.145.209', 'L01.143'], ['I01.880.604.583.427.134', 'N03.706.535.489.134', 'N04.452.859.198', 'N05.715.360.300.715.245'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['I01.615.500.300'], ['K01.752.566.479.147.750', 'N04.452.758.788.300.750', 'N05.350.268.750', 'N05.700.685.300.750'], ['K01.752.566.479.173', 'N... | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Humanities [K]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Cross-talk between pRb/E2F and Wnt/beta-catenin pathways: E2F1 induces axin2 leading to repression of Wnt signalling and to increased cell death. | The pRb/E2F and Wnt/beta-catenin pathways are two of the most frequently deregulated pathways in human cancers. In this study, we show that E2F1 up-regulates the expression of axin2. Further, we show that axin2 can repress Wnt signalling leading to reduced cell growth and increased cell death. This represents cross-tal... | ['Animals', 'Cell Cycle Proteins', 'Cell Death', 'Cells, Cultured', 'Cloning, Molecular', 'Cytoskeletal Proteins', 'DNA-Binding Proteins', 'E2F Transcription Factors', 'E2F1 Transcription Factor', 'Intercellular Signaling Peptides and Proteins', 'Rats', 'Retinoblastoma Protein', 'Signal Transduction', 'Trans-Activators... | 15,572,025 | [['B01.050'], ['D12.776.167'], ['G04.146'], ['A11.251'], ['E05.393.220'], ['D12.776.220'], ['D12.776.260'], ['D12.776.930.211'], ['D12.644.360.024.328.049', 'D12.776.157.057.158.049', 'D12.776.476.024.420.049', 'D12.776.660.769.049', 'D12.776.930.211.500'], ['D12.644.276', 'D12.776.467', 'D23.529'], ['B01.050.150.900.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Morphological identification of simulium sanctipauli and S. yahense in Liberia and comparison of results with those of enzyme electrophoresis. | Simulium sanctipauli and S. yahense have been incriminated as the main vectors of Onchocerca volvulus in the rain-forest zone of Liberia. An accurate identification of the females of the two species which breed in different types of water-courses but are morphologically similar is essential for a proper study of their ... | ['Animals', 'Electrophoresis, Starch Gel', 'Female', 'Genetic Variation', 'Insect Vectors', 'Liberia', 'Phosphoglucomutase', 'Simuliidae', 'Species Specificity'] | 6,240,818 | [['B01.050'], ['E05.196.401.485', 'E05.301.300.402'], ['G05.365'], ['N06.850.335.188.100.500', 'N06.850.520.203.375.100.500'], ['Z01.058.290.190.425'], ['D08.811.399.520.750.625'], ['B01.050.500.131.617.720.500.500.750.712.500.937'], ['G16.824']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis. | Embryonic stem (ES) cells can differentiate in vitro to produce the endothelial and hematopoietic precursor, the hemangioblasts, which are derived from the mesoderm germ layer. Differentiation of Bry(GFP/+) ES cell to hemangioblasts can be followed by the expression of the Bry(GFP/+) and Flk1 genes. Proteomic and trans... | ['Animals', 'Cell Differentiation', 'Embryonic Stem Cells', 'Fetal Proteins', 'Gene Expression Profiling', 'Gene Expression Regulation, Developmental', 'Green Fluorescent Proteins', 'Hematopoiesis', 'Metabolic Networks and Pathways', 'Mice', 'Protein Array Analysis', 'Proteomics', 'RNA, Messenger', 'Reproducibility of ... | 18,045,800 | [['B01.050'], ['G04.152'], ['A11.872.700.250'], ['D12.776.320'], ['E05.393.332'], ['G05.308.310'], ['D12.776.532.265'], ['G04.152.825', 'G09.188.343'], ['G03.493'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.588.570.700', 'E05.601.680'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Differential regulation of phasic dopamine release in the forebrain by the VTA noradrenergic receptor signaling. | Phasic dopamine (DA) release from the ventral tegmental area (VTA) into forebrain structures is implicated in associative learning and conditional stimulus (CS)-evoked behavioral responses. Mounting evidence points to noradrenaline signaling in the VTA as an important regulatory input. Accordingly, adrenergic receptor ... | ['Animals', 'Dopamine', 'Male', 'Prosencephalon', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Adrenergic, alpha', 'Signal Transduction', 'Ventral Tegmental Area'] | 31,001,835 | [['B01.050'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['A08.186.211.200'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D12.776.543.750.670.300.300.300', 'D12.776.543.750.695.150.300.300', 'D12.776.543.750.720.330.300.300'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
STM investigation of temperature-dependent two-dimensional supramolecular architectures of C60 and amino-tetraphenylporphyrin on Ag(110). | Multicomponent supramolecular self-assemblies of exceptional long-range order and low defectivity are obtained if C(60) and 5-(4-aminophenyl)-10,15,20-triphenylporphyrin (TPP-NH2) are assembled on Ag(110) by sequential evaporation in the submonolayer range of TPP-NH2 and fullerene on the substrate surface and subsequen... | ['Fullerenes', 'Macromolecular Substances', 'Microscopy, Scanning Tunneling', 'Particle Size', 'Porphyrins', 'Silver', 'Surface Properties', 'Temperature'] | 19,810,724 | [['D01.268.150.250', 'J01.637.512.600.612.350'], ['D05'], ['E01.370.350.515.666.500', 'E05.595.666.500'], ['G02.712'], ['D03.383.129.578.840.500', 'D03.633.400.909.500', 'D04.345.783.500', 'D23.767.727'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812'], ['G02.860'], ['G01.906.595', 'G16.500.275.063.725.710', ... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Spatial Patterns of Inshore Marine Soundscapes. | Passive acoustic monitoring was employed to investigate spatial patterns of soundscapes within a marine reserve. High energy level broadband snaps dominated nearly all habitat soundscapes. Snaps, the principal acoustic feature of soundscapes, were primarily responsible for the observed spatial patterns, and soundscapes... | ['Acoustics', 'Ecosystem', 'Geography', 'Ireland', 'Seawater', 'Spatial Analysis'] | 26,611,021 | [['H01.671.031'], ['G16.500.275.157', 'N06.230.124'], ['H01.277.500'], ['Z01.542.467', 'Z01.639.587'], ['G16.500.275.725.500'], ['E05.318.740.933', 'N05.715.360.750.746', 'N06.850.520.830.933']] | ['Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Comparison of generalized phase contrast and computer generated holography for laser image projection. | Laser projection based on phase modulation promises several advantages over amplitude modulation. We examine and compare the merits of two phase modulation techniques; phase-only computer generated holography and generalized phase contrast, for the application of dynamic laser image projection. We adopt information the... | ['Data Display', 'Holography', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Lasers', 'Microscopy, Phase-Contrast', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 18,542,636 | [['F02.784.412.221', 'L01.296'], ['E01.370.350.400.500', 'E01.370.350.600.300'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E07.632.490', 'E07.710.520'], ['E01.370.350.515.513.569', 'E05.490.630.569', 'E05.595.513.569'], ['E05.318.370.725', 'E05.337.... | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
[Oestriol - its application to clinical practice in gynaecology (author's transl)]. | Oestriol preparations were applied to 107 patients with genital decent or genital prolapse. The treatment was both presurgical and postoperative. Oestriol was found to have strong effects on the vaginal epithelium, and the absence of any proliferative effect upon the endometrium was confirmed. The defence position of b... | ['Estriol', 'Female', 'Humans', 'Postoperative Care', 'Preoperative Care', 'Uterine Prolapse'] | 532,444 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Profile Likelihood-Based Confidence Intervals and Regions for Structural Equation Models. | Structural equation models (SEM) are widely used for modeling complex multivariate relationships among measured and latent variables. Although several analytical approaches to interval estimation in SEM have been developed, there lacks a comprehensive review of these methods. We review the popular Wald-type and lesser ... | ['Algorithms', 'Computer Simulation', 'Confidence Intervals', 'Humans', 'Likelihood Functions', 'Models, Statistical', 'Psychometrics'] | 25,925,009 | [['G17.035', 'L01.224.050'], ['L01.224.160'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.52... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
[Simplification of plaque index method of Quigley and Hein]. | It was tested to reduce the number of teeth surfaces to graduate plaque with the scale by Qugiley and Hein without loss of representation to total number of (all existing) teeth. Incisivi and canini (oral + vestibular surfaces) of lower jaw showed a high representation (over 80% of all cases) of total plaque value (all... | ['Dental Health Surveys', 'Dental Plaque Index', 'Humans'] | 2,815,170 | [['E05.318.308.980.438.300', 'E06.208', 'N05.715.360.300.800.438.300', 'N06.850.520.308.980.438.300', 'N06.890.160'], ['E05.318.308.980.438.300.300', 'E06.208.250', 'N05.715.360.300.800.438.300.325', 'N06.850.520.308.980.438.300.300', 'N06.890.160.090'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Rhabdomyoblastic pulmonary lesions in a patient with Wilms tumor: choristomas or metastases? | New lesions that occur while patients are receiving treatment for malignant tumors may represent not only difficulties in arriving at the correct diagnosis, but also impact on subsequent therapeutic options. We encountered a patient developing new pulmonary lesions during and after receiving treatment for Stage II Wilm... | ['Biopsy', 'Cell Differentiation', 'Choristoma', 'Humans', 'Kidney Neoplasms', 'Lung Neoplasms', 'Muscle Cells', 'Wilms Tumor'] | 15,926,167 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['G04.152'], ['C23.300.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Combined wear and ageing of ceramic-on-ceramic bearings in total hip replacement under edge loading conditions. | Ceramic-on-ceramic bearings in total hip replacement have shown the potential to provide low wear solutions in hip replacement. Assessing the tribological performance of these materials is important to predict their long-term performance in patients. In this study, a methodology was devised to assess the tribological i... | ['Aluminum Oxide', 'Arthroplasty, Replacement, Hip', 'Ceramics', 'Gait', 'Stress, Mechanical', 'Time Factors', 'Weight-Bearing', 'Zirconium'] | 31,185,443 | [['D01.056.050', 'D01.650.550.050'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['J01.637.153'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['G01.374.835'], ['G01.910.857'], ['G01.374.965'], ['D01.268.556.950', 'D01.268.956.937', 'D01.552.544.950']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Structure-function analysis of cell adhesion by neural (N-) cadherin. | To investigate the possible biological function of the lateral "strand dimer" observed in crystal structures of a D1 domain extracellular fragment from N-cadherin, we have undertaken site-directed mutagenesis studies of this molecule. Mutation of most residues important in the strand dimer interface abolish the ability... | ['Animals', 'Binding Sites', 'Cadherins', 'Calcium', 'Cell Adhesion', 'Cells, Cultured', 'Crystallography', 'Dimerization', 'Gene Expression', 'Image Processing, Computer-Assisted', 'Mice', 'Molecular Sequence Data', 'Mutagenesis', 'Nerve Tissue Proteins', 'Protein Conformation', 'Protein Structure, Tertiary', 'Recombi... | 9,655,503 | [['B01.050'], ['G02.111.570.120'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.022'], ['A11.251'], ['E05.196.309', 'H01.181.529.240'], ['G02.206', 'G03.230'], ['G05.297'], ['L01.224.308'], ['B01.050.150.900.649.313.992.635.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
The influence of ambient and viewbox light upon visual detection of low-contrast targets in a radiograph. | Thirty-one observers (five radiologists, five radiology residents, and 21 nonradiologists) examined low-contrast images of 13 polyvinylchloride cylinders. Image density ranged from 1.91 to 2.05 OD units with a background density of 2.09 OD units. The experiment tested visual performance under various clinically relevan... | ['Humans', 'Lighting', 'Radiographic Image Enhancement', 'Radiology', 'Visual Perception'] | 7,129,822 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.230.150.410'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.308.380.600'], ['H02.403.740'], ['F02.463.593.932']] | ['Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Intrahepatic hematoma requiring hepatic artery embolization: a rare complication of extracorporeal shock wave lithotripsy. | Extracorporeal shock wave lithotripsy is a well-established treatment modality for renal calculi since the 1980s (Urology 1984;23(5):59–66). In general, it is a safe and effective noninvasive therapeutic modality for treatment of urolithiasis. Bleeding complications of this procedure are rare and usually involve the ki... | ['Embolization, Therapeutic', 'Female', 'Hematoma', 'Hepatic Artery', 'Humans', 'Lithotripsy', 'Liver Diseases', 'Middle Aged', 'Radiography', 'Radiology, Interventional'] | 23,791,461 | [['E02.520.360', 'E02.926.500'], ['C23.550.414.838'], ['A07.015.114.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.600', 'E04.943.500'], ['C06.552'], ['M01.060.116.630'], ['E01.370.350.700'], ['H02.403.740.675']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Reliability and Validity of an Interviewer-Administered Adaptation of the Youth Self-Report for Mental Health Screening of Vulnerable Young People in Ethiopia. | OBJECTIVE: Evaluate the reliability and validity of the Youth Self-Report (YSR) as a screening tool for mental health problems among young people vulnerable to HIV in Ethiopia.DESIGN: A cross-sectional assessment of young people currently receiving social services.METHODS: Young people age 15-18 participated in a study... | ['Adolescent', 'Anxiety', 'Attention Deficit Disorder with Hyperactivity', 'Cross-Sectional Studies', 'Depression', 'Ethiopia', 'Ethnic Groups', 'Female', 'HIV Infections', 'Humans', 'Male', 'Mental Disorders', 'Observer Variation', 'Prevalence', 'Psychology, Adolescent', 'Reproducibility of Results', 'Risk', 'Self Rep... | 26,863,626 | [['M01.060.057'], ['F01.470.132'], ['F03.625.094.150'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.145.126.350'], ['Z01.058.290.120.310'], ['M01.686.754', 'N01.224.317'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400',... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Progress report from the International Bone Marrow Transplant Registry. | The International Bone Marrow Transplant Registry receives and analyses detailed information contributed by more than 200 transplant teams worldwide. This collaborative research program has grown rapidly; there are now more than 15,000 cases in the database. This progress report summarizes the current status of bone ma... | ['Anemia, Aplastic', 'Bone Marrow Transplantation', 'Graft vs Host Disease', 'Humans', 'Leukemia', 'Registries', 'T-Lymphocytes', 'Tissue Donors'] | 1,525,599 | [['C15.378.071.085', 'C15.378.190.223.250'], ['E02.095.147.725.040', 'E04.936.580.040'], ['C20.452'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.300.715.700', 'N06.850.520.308.970'], ['A11.118.637.555.567.569', 'A15.145.229.637.555.567.569', 'A1... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Minimally invasive transaortic edge-to-edge repair of the mitral valve. | Clinically significant mitral regurgitation is often found in conjunction with severe aortic valve stenosis. Adding mitral valve surgery to an aortic valve replacement (AVR) increases the operative risk. However, this increased operative risk may be reduced if, during AVR, a standard double-valve surgery is avoided and... | ['Aortic Valve Stenosis', 'Humans', 'Minimally Invasive Surgical Procedures', 'Mitral Valve', 'Mitral Valve Insufficiency'] | 23,610,982 | [['C14.280.484.048.750', 'C14.280.955.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.502'], ['A07.541.510.507'], ['C14.280.484.461']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structure of warfarin in solution. | Warfarin in solution is shown to consist of three interconverting tautomeric structures, two of which are cyclic diastereomeric hemiketals, while the third and minor component is the open-chain intermediate form. The configurations of all the tautomers as well as the major conformations of the cyclic tautomers are assi... | ['Chemical Phenomena', 'Chemistry', 'Isomerism', 'Magnetic Resonance Spectroscopy', 'Models, Molecular', 'Molecular Conformation', 'Solutions', 'Warfarin'] | 915,911 | [['G02'], ['H01.181'], ['G02.111.570.685', 'G02.607.445'], ['E05.196.867.519'], ['E05.599.595'], ['G02.111.570.820'], ['D26.776'], ['D03.383.663.283.446.520.914', 'D03.633.100.150.446.520.914']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Association of serum total iron-binding capacity and its changes over time with nutritional and clinical outcomes in hemodialysis patients. | Serum transferrin, estimated by total iron-binding capacity (TIBC), may be a marker of protein-energy wasting (PEW) in maintenance hemodialysis (MHD) patients. We hypothesized that low TIBC or its fall over time is associated with poor clinical outcomes. In 807 MHD patients in a prospective 5-year cohort, associations ... | ['Adult', 'Aged', 'Anthropometry', 'Body Composition', 'Female', 'Humans', 'Iron', 'Kidney Failure, Chronic', 'Los Angeles', 'Male', 'Middle Aged', 'Nutritional Status', 'Prospective Studies', 'Protein-Energy Malnutrition', 'Quality of Life', 'Renal Dialysis', 'Transferrin'] | 19,136,818 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['Z01.107.567.8... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Semihistone protein A24 replaces H2A as an integral component of the nucleosome histone core. | The semihistone protein, A24, was shown to be a stable minor component of purified salt-washed nucleosome core particles. A24 was also shown to become integrated into nucleohistone during reconstitution in a manner characteristic of the core histones. Purified A24 in solution was shown to exhibit the same specificity o... | ['Animals', 'Cattle', 'Cell Nucleus', 'Chromatin', 'Deoxyribonucleoproteins', 'Histones', 'Macromolecular Substances', 'Molecular Weight', 'Nucleoproteins', 'Sodium Chloride', 'Thymus Gland'] | 286,291 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An outbreak of joint and cutaneous infections caused by non-tuberculous mycobacteria after corticosteroid injection. | OBJECTIVES: An outbreak of joint and cutaneous infections among patients who had been injected at a single clinic in South Korea was investigated.METHODS: In this retrospective case-control study, 61 cases were diagnosed based on symptoms and signs of septic arthritis or cutaneous infection that developed after injecti... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Arthritis, Infectious', 'Child', 'Disease Outbreaks', 'Drug Contamination', 'Female', 'Humans', 'Injections', 'Male', 'Middle Aged', 'Mycobacterium Infections, Nontuberculous', 'Nontuberculous Mycobacteria', 'Republic of Korea', 'Retrospective Studies', 'Risk Factor... | 26,026,822 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C01.100', 'C05.550.114.099'], ['M01.060.406'], ['N06.850.290'], ['N06.850.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530'], ['M01.060.116.630'], ['C01.150.252.410.040.552.475'], ['B03.510.024.962.500.720', 'B03... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
In vitro and in vivo evaluation of progesterone implants based on new biodegradable poly(glutamic and glutamate esters) copolymers. | New biodegradable polypeptidic copolymers of glutamic acid and tert-butyloxycarbonylmethyl glutamate were evaluated as implantable drug delivery systems. Three copolymers varying in degrees of esterification, which is inversely proportional to the number of glutamic residues, were selected for their range of hydrophili... | ['Animals', 'Biocompatible Materials', 'Biodegradation, Environmental', 'Drug Implants', 'Evaluation Studies as Topic', 'Hydrogen-Ion Concentration', 'Models, Statistical', 'Molecular Structure', 'Oligopeptides', 'Polyglutamic Acid', 'Progesterone', 'Rats', 'Rats, Sprague-Dawley'] | 7,539,629 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['D26.255.210.315'], ['E05.337', 'N05.715.360.335'], ['G02.300'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['G02.111.570', 'G02.466'], ['D12.644.456'], ['D12.125.067.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
A splicing model-based DNA-computing approach on microfluidic chip. | DNA computing is a new computation form based on DNA biochemical reactions, which is mainly composed of sticker and splicing computation models. In this work, a microfluidic chip-based approach was established for splicing model-based DNA computing. A finite automaton with two input symbols (a, b) and three states (S0,... | ['Computers, Molecular', 'Microfluidic Analytical Techniques', 'Microfluidics', 'Pattern Recognition, Automated', 'RNA Splicing'] | 19,798,677 | [['L01.224.230.260.315', 'L01.224.300'], ['E05.588.465'], ['E05.830.666', 'H01.671.808.500', 'J01.897.520.500.500'], ['L01.399.750'], ['G02.111.760.700', 'G03.839.700', 'G05.308.700.700']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Cerebral protection during open-heart surgery. | To reduce the incidence of cerebral damage after open-heart surgery measures were undertaken based on physiological principles and consideration of the possible injury caused by microemboli. Intellectual function was measured by psychometric tests before and after operation. The results were compared with those of an e... | ['Adult', 'Blood Pressure', 'Brain Diseases', 'Cardiac Surgical Procedures', 'Cardiopulmonary Bypass', 'Filtration', 'Humans', 'Intracranial Embolism and Thrombosis', 'Middle Aged', 'Oxygenators', 'Psychological Tests', 'Time Factors'] | 594,930 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C10.228.140'], ['E04.100.376', 'E04.928.220'], ['E04.292.413'], ['E05.196.454', 'G01.280', 'G02.263'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.525', 'C14.907.253.566', 'C14.907.355.590.213'], ['M01.060.116.630'], ['E07.652'], ['F... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Multivisceral surgery in advanced gastric carcinoma. | From April 1986 to June 1994 a total of 284 patients with gastric carcinoma were admitted to the authors' department. Mainly advanced tumour stages were seen: stage I = = 23%, II = 13%, III = 22% and IV = 42%. In 256 tumour resections (resection rate = 90%) multivisceral surgery (mvs) was necessary in 146 patients (mvs... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Male', 'Middle Aged', 'Postoperative Complications', 'Prognosis', 'Stomach Neoplasms', 'Survival Rate', 'Viscera'] | 9,262,713 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.767'], ['E01.789'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.8... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Induction of meiotic maturation in Xenopus oocytes by 12-O-tetradecanoylphorbol 13-acetate. | Fully grown Xenopus oocytes are physiologically arrested at the G2/prophase border of the first meiotic division. Addition in vitro of progesterone or insulin causes release of the G2/prophase block and stimulates meiotic cell division of the oocyte, leading to maturation of the oocyte into an unfertilized egg. The pos... | ['Animals', 'Female', 'Fructosediphosphates', 'Inositol 1,4,5-Trisphosphate', 'Inositol Phosphates', 'Insulin', 'Kinetics', 'Meiosis', 'Oocytes', 'Progesterone', 'Tetradecanoylphorbol Acetate', 'Xenopus laevis'] | 3,549,336 | [['B01.050'], ['D09.894.417.313.300', 'D09.894.417.592.300'], ['D02.033.800.519.400.350', 'D09.853.519.400.350', 'D09.894.480.350'], ['D02.033.800.519.400', 'D09.853.519.400', 'D09.894.480'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['G01.374.661', 'G02.111.490'], ['G04.144.220.220.687', 'G05.113... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Crossbreds of Jersey x Holstein compared with pure Holsteins for body weight, body condition score, dry matter intake, and feed efficiency during the first one hundred fifty days of first lactation. | Jersey x Holstein crossbred (JxH) cows (n = 24) were compared with pure Holstein cows (n = 17) for body weight, body condition score, dry matter intake (DMI), and feed efficiency during the first 150 d of first lactation. Cows were housed in the University of Minnesota dairy facility at the St. Paul campus and calved f... | ['Animals', 'Body Constitution', 'Body Weight', 'Cattle', 'Eating', 'Energy Metabolism', 'Female', 'Hybridization, Genetic', 'Lactation', 'Least-Squares Analysis', 'Species Specificity', 'Time Factors'] | 18,765,631 | [['B01.050'], ['E01.370.600.115', 'G07.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['B01.050.150.900.649.313.500.380.271'], ['G07.203.650.283', 'G10.261.330'], ['G03.295'], ['E05.820.150.390', 'G05.090.390'], ['G08.686.523', 'G08.686.702.50... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Kveim induced lymphocyte reactivity in patients and household contacts of patients with Crohn's disease. | In vitro lymphocyte thymidine uptake in response to validated Kveim antigen CR-1 was studied in 18 patients with Crohn's disease and in 30 of their household contacts. Two of the patients and 3 of the contacts demonstrated a stimulation index of 2 or greater. None of 15 control subjects demonstrated such reactivity. Ly... | ['Adult', 'Crohn Disease', 'Environmental Exposure', 'Humans', 'Kveim Test', 'Lymphocyte Activation', 'Lymphocytes', 'Middle Aged', 'Skin Tests'] | 7,420,405 | [['M01.060.116'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812.871.300.540', 'E05.200.812.871.300.540', 'E05.478.594.890.300.540'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Tumor anti-angiogenic gene therapy with microencapsulated recombinant CHO cells. | Microencapsulation of recombinant cells is a novel promising approach to tumor therapy in which therapeutic protein is sustainable and long-term delivered by microencapsulated cells. The semi-permeable membrane of microcapsule can protect cell from host's immune rejection, increase the chemical stability of therapeutic... | ['Animals', 'CHO Cells', 'Capsules', 'Cells, Immobilized', 'Cricetinae', 'Cricetulus', 'Endostatins', 'Gene Expression', 'Genetic Therapy', 'Melanoma', 'Membranes, Artificial', 'Mice', 'Neovascularization, Pathologic', 'Time Factors'] | 17,277,990 | [['B01.050'], ['A11.251.210.200', 'A11.436.155'], ['D26.255.150'], ['A11.270'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['D12.644.276.100.450.750', 'D12.776.467.100.450.750', 'D12.776.860.300.250.400.537.500', 'D23.529.100.450.750'], ['G05.297'], ['E02.095.301', 'E0... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Biomimetic recognition and immunochemical assay of ligand binding to collagen. | PURPOSE: The objectives of this investigation were to analyze the adhesive interactions between type 1 collagen and two hydrophilic monomer primers (ligands) for dentin bonding through computer modeling and a novel immunochemical binding assay method.MATERIALS AND METHODS: The hydrophilic monomers studied included 2-hy... | ['Acrylates', 'Antibodies, Monoclonal', 'Binding Sites', 'Binding Sites, Antibody', 'Biomimetics', 'Collagen Type I', 'Computer Simulation', 'Dental Bonding', 'Dentin', 'Dentin-Bonding Agents', 'Electrochemistry', 'Humans', 'Ligands', 'Methacrylates', 'Models, Biological', 'Models, Chemical', 'Organophosphorus Compound... | 12,729,079 | [['D02.241.081.069'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.120'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.232', 'G12.125'], ['H01.158.550.100', 'J01.897.120.100'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['L0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
[A novel mutation in GCH1 gene causes dopa-responsive dystonia]. | OBJECTIVE: To identify potential mutation of the GCH1 gene in a Chinese family affected with dopa-responsive dystonia.METHODS: Genomic DNA of patients was extracted from peripheral blood samples. The 6 exons of the GCH1 gene and at least 100 bp of flanking intronic sequences were amplified with PCR. Potential mutations... | ['Adolescent', 'Adult', 'Base Sequence', 'Child', 'Dystonic Disorders', 'Exons', 'Female', 'Frameshift Mutation', 'GTP Cyclohydrolase', 'Humans', 'Male', 'Middle Aged', 'Molecular Sequence Data', 'Pedigree', 'Young Adult'] | 25,119,902 | [['M01.060.057'], ['M01.060.116'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['M01.060.406'], ['C10.228.662.300'], ['G05.360.340.024.340.137.232'], ['G05.365.590.265'], ['D08.811.277.151.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['L01.453.245.667'], ['E05.393.673'], [... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
DHPLC analysis of patients with Nevoid Basal Cell Carcinoma Syndrome reveals novel PTCH missense mutations in the sterol-sensing domain. | Nevoid Basal Cell Carcinoma Syndrome (NBCCS) is an autosomal dominant disorder characterised by multiple basal cell carcinomas, palmar and plantar pitting, odontogenic keratocysts of the jaws and bilamellar calcification of the falx. Mutations in the PTCH gene are responsible for NBCCS but most studies have found mutat... | ['Basal Cell Nevus Syndrome', 'Chromatography, High Pressure Liquid', 'DNA Mutational Analysis', 'Female', 'Genes, Dominant', 'Heterozygote', 'Humans', 'Male', 'Mutation, Missense', 'Patched Receptors', 'Patched-1 Receptor', 'Protein Structure, Tertiary', 'Receptors, Cell Surface', 'Skin Neoplasms', 'Sterols'] | 16,088,933 | [['C04.182.089.530.690.150', 'C04.557.470.200.165.150', 'C04.557.470.565.165.150', 'C04.700.175', 'C05.116.099.105', 'C05.500.470.690.150', 'C07.320.450.670.130', 'C16.131.077.130', 'C16.320.700.175'], ['E05.196.181.400.300'], ['E05.393.760.700.300'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.380.383'], ['B01.0... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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