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Measuring quality of life in palliative care for Parkinson's disease: A clinimetric comparison. | INTRODUCTION: Quality of life (QOL) assessments allow for more complete evaluation of patients' lived experiences in relation to chronic conditions, such as Parkinson's disease (PD). In palliative care, such instruments are vital to ensure QOL issues are catalogued and addressed for patients. However, little is known r... | ['Aged', 'Aged, 80 and over', 'Disease Progression', 'Female', 'Humans', 'Lewy Body Disease', 'Male', 'Middle Aged', 'Multiple System Atrophy', 'Outcome Assessment, Health Care', 'Palliative Care', 'Parkinson Disease', 'Parkinsonian Disorders', 'Patient Outcome Assessment', 'Psychometrics', 'Quality of Life', 'Reproduc... | 31,253,494 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.079.862.400', 'C10.228.140.380.422', 'C10.228.662.600.200', 'C10.574.928.500', 'F03.615.400.512'], ['M01.060.116.630'], ['C10.177.575.550', 'C10.228.140.079.612', 'C10.228.662.550', 'C10.57... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Effects of Cistanche deserticola on behavior and signs of cataract and retinopathy in senescence-accelerated OXYS rats. | ETHNOPHARMACOLOGICAL RELEVANCE: Cistanche deserticola (?D) has been traditionally used in the Chinese medicine as a tonic, vasodilator and neuroprotective agent.AIM OF THE STUDY: To investigate the effect of CD on the age-related behavior decline and cataract and retinopathy development in senescent accelerated OXYS ra... | ['Animals', 'Behavior, Animal', 'Cataract', 'Cistanche', 'Male', 'Maze Learning', 'Ophthalmoscopy', 'Plant Extracts', 'Rats', 'Rats, Wistar', 'Retinal Diseases'] | 22,020,276 | [['B01.050'], ['F01.145.113'], ['C11.510.245'], ['B01.650.940.800.575.912.250.583.670.175'], ['F02.463.425.874.500'], ['E01.370.380.560'], ['D20.215.784.500', 'D26.667'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['C11.768']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Acceleration of osmotic dehydration process through ohmic heating of foods: raspberries (Rubus idaeus)]. | Raspberries (Rubus idaeus) were osmotically dehydrated by applying a conventional method under the supposition of a homogeneous solution, all in a 62% glucose solution at 50 degrees C. Raspberries (Rubus idaeus) were also osmotically dehydrated by using ohmic heating in a 57% glucose solution at a variable voltage (to ... | ['Desiccation', 'Food Handling', 'Fruit', 'Hot Temperature', 'Osmosis', 'Rosaceae', 'Time Factors'] | 17,992,985 | [['E05.196.335', 'G02.176'], ['J01.576.423.200'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['G01.154.090.750', 'G02.111.655', 'G02.691', 'G02.723.495'], ['B01.650.940.800.57... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
The reaction of nitrogen monoxide and of nitrite with deoxyhaemocyanin and methaemocyanin of Helix pomatia. | Deoxyhaemocyanin, treated with NO under strictly anaerobic conditions, yielded methaemocyanin and N2O in a fast reaction. In a further slow reaction this methaemocyanin lost its triplet electron paramagnetic resonance (EPR) signal at g = 4 and yielded a nitrosyl derivative with a characteristic g = 2 Cu(II) EPR signal,... | ['Animals', 'Chemical Phenomena', 'Chemistry', 'Circular Dichroism', 'Copper', 'Electron Spin Resonance Spectroscopy', 'Ferric Compounds', 'Helix, Snails', 'Hemocyanins', 'Hydrogen-Ion Concentration', 'Nitric Oxide', 'Nitrites', 'Nitrous Oxide', 'Time Factors'] | 37,076 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A simple model for learning stereotactic skills in ultrasound-guided amniocentesis. | BACKGROUND: Amniocentesis is an important procedure for antenatal diagnosis but requires stereotactic skill acquisition that may be facilitated by the use of a model.TECHNIQUE: A model using a gelatin mold with "targets" within is created. The model is used to facilitate development of stereotactic skills and to demons... | ['Amniocentesis', 'Gynecology', 'Models, Biological', 'Obstetrics', 'Ultrasonography, Prenatal'] | 9,699,771 | [['E01.370.225.500.384.050', 'E01.370.225.998.329.309', 'E01.370.378.630.050', 'E04.665.600.309', 'E05.200.500.384.050', 'E05.200.998.329.309', 'E05.242.384.050'], ['H02.403.763.750', 'H02.403.810.310'], ['E05.599.395'], ['H02.403.810.450'], ['E01.370.350.850.865', 'E01.370.378.630.865']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of physiotherapy on regaining independent walking in patients with intensive-care-unit-acquired muscle weakness: A cohort study. | OBJECTIVES: To describe physiotherapeutic interventions used in the post-acute inpatient rehabilitation of chronic critically ill patients with intensive-care-unit-acquired muscle weakness, and to determine the influence of such interventions on patients' ability to walk.METHODS: Chronic critically ill patients with in... | ['Cohort Studies', 'Critical Illness', 'Humans', 'Intensive Care Units', 'Muscle Weakness', 'Physical Therapy Modalities', 'Walking'] | 31,544,216 | [['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C23.550.291.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['C05.651.515', 'C10.597.613.593', 'C23.550.695', 'C23.888.592.608.593'], ['E02.779', 'E02.831.535'], ['G11.427.410.568.900', 'G11.427.410.698.277.93... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex. | A critical step in V(D)J recombination is the synapsis of complementary (12/23) recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins to generate the paired complex (PC). Using a facilitated ligation assay and substrates that vary the helical phasing of the RSSs, we provide evidence that one particular ge... | ['Animals', 'Catalysis', 'Chromosome Pairing', 'Energy Transfer', 'Fluorescence Resonance Energy Transfer', 'Fluorescent Dyes', 'Homeodomain Proteins', 'Mice', 'Models, Biological', 'Nuclear Proteins', 'Nucleic Acid Conformation', 'Protein Sorting Signals', 'Recombination, Genetic'] | 17,470,556 | [['B01.050'], ['G02.130'], ['G04.144.220.220.687.883.250', 'G04.144.220.220.781.906.250', 'G05.113.220.687.883.250', 'G05.113.220.781.906.250'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['E05.196.712.516.600.676.500', 'G01.154.240.280', 'G02.111.255.280'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D12.776.260... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Concurrent validity of an isokinetic lift test used for admission to the Swedish Armed Forces. | The aim of this study was to assess the concurrent validity of the IsoKai isokinetic lift test peak force (IsoKaiPeak) in comparison to a submaximal 5-10RM deadlift test (5-10RMDL), and to develop an equation for converting the IsoKaiPeak in Newton (N) to an estimated 1RM (1RMest) deadlift load in kilograms (kg). The p... | ['Adult', 'Exercise Test', 'Female', 'Humans', 'Male', 'Middle Aged', 'Military Personnel', 'Reproducibility of Results', 'Sweden', 'Weight Lifting', 'Young Adult'] | 30,399,188 | [['M01.060.116'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.526.625'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['Z01.542.816.500'], ['I03.450.642.845.950'], ['M01.060.116.815']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
A multifaced DNA ploidy analysis to determine ovarian carcinoma aggressiveness. | A microfluorometric DNA study was conducted on isolated cells from 64 fragments of ovarian epithelial tumors. Data analysis considered the DNA content of the main stemline and the prevalence of cells in the different compartments of the DNA ploidy histogram in relation to the mitotic activity index and the histologic a... | ['Carcinoma', 'DNA, Neoplasm', 'Female', 'Humans', 'Mitotic Index', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Ovarian Neoplasms', 'Ploidies'] | 2,004,301 | [['C04.557.470.200'], ['D13.444.308.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.385.500', 'E05.200.500.385.500', 'E05.242.385.500'], ['C04.697.645', 'C23.550.727.645'], ['E01.789.625'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'],... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Diagnostics for Yaws Eradication: Insights From Direct Next-Generation Sequencing of Cutaneous Strains of Treponema pallidum. | Background: Yaws-like chronic ulcers can be caused by Treponema pallidum subspecies pertenue, Haemophilus ducreyi, or other, still-undefined bacteria. To permit accurate evaluation of yaws elimination efforts, programmatic use of molecular diagnostics is required. The accuracy and sensitivity of current tools remain un... | ['Child', 'Disease Eradication', 'Female', 'Genome, Bacterial', 'Ghana', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Male', 'Melanesia', 'Molecular Diagnostic Techniques', 'Real-Time Polymerase Chain Reaction', 'Sequence Analysis, DNA', 'Skin Ulcer', 'Treponema pallidum', 'Whole Genome Sequencing', 'Yaws'] | 29,045,605 | [['M01.060.406'], ['N06.850.275'], ['G05.360.340.358.207'], ['Z01.058.290.190.320'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.639.760.590'], ['E01.370.225.880', 'E05.200.880', 'E05.393.520'], ['E05.393.620.500.706'], ['E05.393.760.700'], ['C17.800.893'], ['B03.440.425.410.711.795.840'... | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Molecular cloning of the Pseudomonas putida glyoxalase I gene in Escherichia coli. | The glyoxalase I gene of Pseudomonas putida was cloned onto a vector plasmid pBR 322 as a 7.5 kilobase Sau 3AI fragment of chromosomal DNA and the hybrid plasmid was designated pGI 318. The gene responsible for the glyoxalase I activity in pGI 318 was recloned in pBR 322 as a 2.2 kilobase Hin dIII fragment and was desi... | ['Cell Division', 'Cloning, Molecular', 'DNA Restriction Enzymes', 'DNA, Bacterial', 'DNA, Recombinant', 'Escherichia coli', 'Lactoylglutathione Lyase', 'Lyases', 'Microscopy, Electron', 'Plasmids', 'Pseudomonas', 'Pyruvaldehyde', 'Transformation, Bacterial'] | 2,820,418 | [['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E05.393.220'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['D13.444.308.212'], ['D13.444.308.460'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D08.811.520.300.500'], ['D08.811.520'], ['E01... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ineffectiveness of continuous 5-fluorouracil as salvage therapy for ovarian cancer. | 5-Fluorouracil (5-FU) is an antimetabolite chemotherapy, which selectively functions at the S phase of the cell cycle. It is a short-acting agent with a serum half-life of approximately 11 minutes. Increased efficacy with this drug could theoretically be provided by sustained infusion over the doubling time of a tumor.... | ['Adult', 'Aged', 'Drug Administration Schedule', 'Female', 'Fluorouracil', 'Humans', 'Infusions, Intravenous', 'Middle Aged', 'Ovarian Neoplasms', 'Prospective Studies', 'Salvage Therapy', 'Survival Analysis'] | 7,977,166 | [['M01.060.116'], ['M01.060.116.100'], ['E02.319.283'], ['D03.383.742.698.875.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['M01.060.116.630'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['E05.318.37... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of absorption and coherent interference in the photoluminescence and electroluminescence spectra of SRO/SRN MIS capacitors. | In this paper we present a technique that can be used to study the effect of absorption and coherent interference in the luminescence of multilayer structures. We apply the technique to the measured photoluminescence and electroluminescence spectra of MIS capacitors where the insulator is composed of a silicon rich oxi... | ['Absorption', 'Electric Capacitance', 'Electric Conductivity', 'Electromagnetic Fields', 'Electronics', 'Light', 'Luminescent Measurements', 'Materials Testing', 'Spectrum Analysis'] | 23,609,716 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['G01.358.500.249.270'], ['G01.358.500.249.277'], ['G01.358.500.260', 'G01.358.750.500'], ['H01.671.293'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.196.712.516'], ['E05.570'], ['E05.196.867']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis. | Cathepsin B (CTSB) is a proteolytic enzyme potentially modulating angiogenic processes and extracellular matrix remodeling. While matrix metalloproteinases are shown to be implicated in tissue fibrosis and vasculopathy associated with systemic sclerosis (SSc), the role of cathepsins in this disease has not been well st... | ['Animals', 'Case-Control Studies', 'Cathepsin B', 'Endothelial Cells', 'Enzyme-Linked Immunosorbent Assay', 'Extracellular Matrix', 'Female', 'Gene Silencing', 'Humans', 'Male', 'Mice', 'Microcirculation', 'Scleroderma, Systemic', 'Skin', 'Transforming Growth Factor beta', 'Vascular Diseases'] | 22,384,200 | [['B01.050'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D08.811.277.656.224.125', 'D08.811.277.656.262.500.133', 'D08.811.277.656.300.200.133'], ['A11.436.275'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Facial flushing after alcohol intake as a predictor for a high risk of synchronous or metachronous cancer of the upper gastrointestinal tract. | Background: In Japan, there has been a lot of reports showing an association between facial flushing after light alcohol consumption and heterozygosity for inactive aldehyde dehydrogenase-2 (ALDH2). Persons with inactive ALDH2 may have a higher risk of alcohol-related oral, pharyngeal and esophageal cancers, compared w... | ['Aged', 'Alcohol Drinking', 'Female', 'Flushing', 'Gastrointestinal Neoplasms', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasms, Multiple Primary', 'Neoplasms, Second Primary', 'Proportional Hazards Models', 'Retrospective Studies', 'Risk Factors', 'Surveys and Questionnaires', 'Upper Gas... | 29,136,221 | [['M01.060.116.100'], ['F01.145.317.269'], ['C23.888.885.344'], ['C04.588.274.476', 'C06.301.371', 'C06.405.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['C04.651'], ['C04.6... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Involvement of RBP4 in Diabetic Atherosclerosis and the Role of Vitamin D Intervention. | The purposes of this study were to evaluate the expression of retinol-binding protein 4 (RBP4) in diabetic rats with atherosclerosis and to investigate the role of vitamin D intervention. Male Wistar rats were randomly divided into 4 groups, including the control group (NC), the diabetic rats (DM1), the untreated diabe... | ['Animals', 'Aorta, Thoracic', 'Aortic Diseases', 'Atherosclerosis', 'Biomarkers', 'Blood Glucose', 'Diabetes Mellitus, Experimental', 'Diabetic Angiopathies', 'Diet, High-Fat', 'Insulin', 'Insulin Resistance', 'Lipids', 'Male', 'Plaque, Atherosclerotic', 'Rats, Wistar', 'Retinol-Binding Proteins, Plasma', 'Vitamin D'] | 30,186,876 | [['B01.050'], ['A07.015.114.056.372'], ['C14.907.109'], ['C14.907.137.126.307'], ['D23.101'], ['D09.947.875.359.448.500'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C14.907.320', 'C19.246.099.500'], ['G07.203.650.240.267'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['C18.452.394... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Clinical processes in a high resolution clinic of specialist outpatient clinics]. | OBJECTIVES: The high resolution clinic (HRC) is an outpatient care process by which treatment and diagnosis are established, recorded, and completed in a single day. The aim of this study was to assess the extent to which patients with medical conditions may benefit from a single consultation system.MATERIAL AND METHOD... | ['Ambulatory Care', 'Ambulatory Care Facilities', 'Delivery of Health Care', 'Efficiency, Organizational', 'Female', 'Humans', 'Male', 'Middle Aged'] | 27,793,461 | [['E02.760.106', 'N02.421.585.106'], ['N02.278.035'], ['N04.590.374', 'N05.300'], ['N04.452.209.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak. | The skeletal muscle dihydropyridine receptor (DHPR) and ryanodine receptor (RyR1) are known to engage a form of conformation coupling essential for muscle contraction in response to depolarization, referred to as excitation-contraction coupling. Here we use WT and Ca(V)1.1 null (dysgenic) myotubes to provide evidence f... | ['Animals', 'Calcium', 'Calcium Channels, L-Type', 'Calcium Signaling', 'Halogenated Diphenyl Ethers', 'Ion Channel Gating', 'Mice', 'Mice, Mutant Strains', 'Muscle Contraction', 'Muscle Fibers, Skeletal', 'Ryanodine Receptor Calcium Release Channel', 'Sarcolemma'] | 21,482,776 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.157.530.400.150.400', 'D12.776.543.550.450.150.400', 'D12.776.543.585.400.150.400'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['D02.355.726.601', 'D02.455.426.559.389.657.654.601'], ['G02.111.820.400', 'G04.835.400', 'G... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cutaneous nocardiosis in a cat. | A 7-year-old cat was found to have multiple cutaneous lesions caused by Nocardia asteroides infection. The cat was treated successfully with potentiated sulfonamides and a combination of ampicillin and erythromycin. | ['Animals', 'Cat Diseases', 'Cats', 'Male', 'Nocardia Infections', 'Skin Diseases, Infectious'] | 3,700,231 | [['B01.050'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['C01.150.252.410.040.692'], ['C01.800', 'C17.800.838']] | ['Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Development of a water tank for X-ray dose measurement in stereotactic radiotherapy (X-knife)]. | This paper presents a novel x-ray dose testing water tank used for the stereotactic radiation therapy system, including its constitution, structure and the method of using it. The water tank has a simple structure of inner and outer sleeves which are connected through a drowned pump and a water pipe in order to control... | ['Equipment Design', 'Radiosurgery', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted'] | 18,581,873 | [['E05.320'], ['E02.815.530', 'E04.525.800.650', 'E05.873.500'], ['E02.815.639'], ['E02.950.825', 'L01.313.500.750.100.710.600.608']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Limitations on microalgal growth at very low photon fluence rates: the role of energy slippage. | The lower limits of photosynthetically useable radiation at which growth and photosynthesis can occur establish the lower boundaries for the extent of photolithotrophy in the biosphere. Photolithotrophic growth denotes the capacity to grow with photons as the sole energy input. Slippage in terms of photosynthetic energ... | ['Energy Transfer', 'Eukaryota', 'Fluorescence', 'Kinetics', 'Light', 'Oxygen', 'Photons', 'Photosynthesis'] | 16,691,367 | [['G01.154.240', 'G02.111.255', 'G02.216'], ['B01'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['G01.374.661', 'G02.111.490'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['D01.268.185.550', 'D01.362.670'], ['G01.249.705', 'G01.358.500.505.650.782', 'G01.590.540.782', 'G0... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Kidney sponge--treatment--case report]. | Medullary sponge kidney (MSK) is a benign asymptomatic developmental anomaly of the kidney mostly seen in adult females. Typical for this morphological abnormality is dilation of the collecting ducts. Intravenosus pyelogram shows accumulation of contrast in dilated ducts giving to the papillae the appearance of a bouqu... | ['Acidosis, Renal Tubular', 'Adult', 'Diagnosis, Differential', 'Female', 'Follow-Up Studies', 'Humans', 'Kidney', 'Kidney Calculi', 'Lithotripsy', 'Medullary Sponge Kidney', 'Radiography', 'Ureteroscopy', 'Urinary Calculi', 'Urinary Tract Infections'] | 16,708,564 | [['C12.777.419.815.093', 'C13.351.968.419.815.093', 'C16.320.831.093', 'C18.452.076.176.210'], ['M01.060.116'], ['E01.171'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419.600.500', 'C12.777.967.2... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The last frontier: rural emergency nurses' perceptions of end-of-life care obstacles. | INTRODUCTION: Caring for dying patients is part of working in a rural emergency department. Rural emergency nurses are prepared to provide life-saving treatments but find there are barriers or obstacles to providing end-of-life (EOL) care. This study was completed to discover the size, frequency, and magnitude of obsta... | ['Adult', 'Alaska', 'Attitude of Health Personnel', 'Cross-Sectional Studies', 'Emergency Nursing', 'Emergency Service, Hospital', 'Environment', 'Female', 'Hospitals, Rural', 'Humans', 'Interprofessional Relations', 'Male', 'Middle Aged', 'Needs Assessment', 'Nevada', 'Nurse-Patient Relations', 'Ohio', 'Perception', '... | 22,683,099 | [['M01.060.116'], ['Z01.107.567.875.580.100'], ['F01.100.050', 'N05.300.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['H02.478.676.200', 'N02.421.533.200'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['G16.500.275', 'N06.230'], ['N02.278.421.518']... | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Ovine myometrial cytosol inhibits phospholipase A activity, in vitro. | Myometrium obtained from pregnant ewes (30-80 days gestation) contains a factor which inhibits phospholipase A2 (PLA2) activity. The activity of this moiety was assessed using an in vitro porcine pancreatic PLA2 assay system. Inhibitory activity was associated with a 35-45000 dalton molecular weight fraction, heat-labi... | ['Animals', 'Chromatography, Thin Layer', 'Cytosol', 'Female', 'In Vitro Techniques', 'Myometrium', 'Phospholipases', 'Phospholipases A', 'Phospholipases A2', 'Pregnancy', 'Sheep'] | 3,432,559 | [['B01.050'], ['E05.196.181.400.537'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['E05.481'], ['A02.633.570.500', 'A05.360.319.679.690', 'A10.690.467.500'], ['D08.811.277.352.100.680', 'D08.811.277.352.640.700'], ['D08.811.277.352.100.680.750'], ['D08.811.277.352.100.680.750.937'], ['G08.68... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of trypanosome infections by polymerase chain reaction (PCR) amplification in wild tsetse flies in Cameroon. | The polymerase chain reaction (PCR) method was used to characterize trypanosome infections in tsetse flies from 3 sleeping sickness foci in Cameroon. The predominant tsetse species found was Glossina palpalis palpalis. An average infection rate of 12.1% was revealed by microscopical examination of 888 non-teneral tsets... | ['Animals', 'Cameroon', 'Insect Vectors', 'Polymerase Chain Reaction', 'Trypanosoma', 'Tsetse Flies'] | 9,651,938 | [['B01.050'], ['Z01.058.290.100.110'], ['N06.850.335.188.100.500', 'N06.850.520.203.375.100.500'], ['E05.393.620.500'], ['B01.268.475.868.887'], ['B01.050.500.131.617.720.500.500.750.400.700']] | ['Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Simultaneous measurement of reactions in microdroplets filled by concentration gradients. | This work describes a technology for performing and monitoring simultaneously several reactions confined in strings of microdroplets having identical volumes but different composition, and travelling with the same speed in parallel channels of a microfluidic device. This technology, called parallel microdroplets techno... | ['Alkaline Phosphatase', 'Equipment Design', 'Escherichia coli', 'Microfluidic Analytical Techniques', 'Protein Binding', 'Protein Denaturation', 'Time Factors', 'Titrimetry'] | 19,495,454 | [['D08.811.277.352.650.035'], ['E05.320'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E05.588.465'], ['G02.111.679', 'G03.808'], ['G01.154.651.750.500', 'G02.111.688.750.500'], ['G01.910.857'], ['E05.196.922']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stromal lamellar dissection of the donor disc: a technique to reduce complications secondary to eccentric trephination during descemet stripping automated endothelial keratoplasty. | PURPOSE: To describe a surgical technique to decrease the incidence and potential complications of an eccentric trephination and improve graft adherence during Descemet stripping automated endothelial keratoplasty.METHODS: Technique description.RESULTS: After resection of the anterior lamella with the microkeratome, th... | ['Corneal Stroma', 'Descemet Stripping Endothelial Keratoplasty', 'Endothelium, Corneal', 'Graft Survival', 'Humans', 'Intraoperative Complications', 'Microdissection', 'Postoperative Complications', 'Tissue Donors'] | 22,893,096 | [['A09.371.060.217.228'], ['E02.095.147.725.262', 'E04.540.825.374.112', 'E04.936.580.262'], ['A09.371.060.067.318', 'A09.371.060.217.318', 'A10.272.491.318'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['E01.370.225.500.620.520', 'E01.370.225.750.600.520', 'E01.370.225.998.2... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Analysis of phosphorus herbicides by ion-pairing reversed-phase liquid chromatography coupled to inductively coupled plasma mass spectrometry with octapole reaction cell. | A reversed phase ion-pairing high performance liquid chromatographic (RPIP-HPLC) method is developed for the separation of two phosphorus herbicides, Glufosinate and Glyphosate as well as Aminomethylphosphonic acid (AMPA), the major metabolite of Glyphosate. Tetrabutylammonium hydroxide is used as the ion-pairing reage... | ['Aminobutyrates', 'Chromatography, Ion Exchange', 'Fresh Water', 'Glycine', 'Helium', 'Herbicides', 'Indicators and Reagents', 'Mass Spectrometry', 'Organophosphorus Compounds', 'Phosphorus', 'Reference Standards', 'Water Pollutants, Chemical'] | 15,503,930 | [['D02.241.081.114.500', 'D12.125.190'], ['E05.196.181.400.383'], ['G16.500.275.280', 'N06.230.232'], ['D12.125.481'], ['D01.268.613.350', 'D01.362.641.352'], ['D27.720.031.700.366', 'D27.888.723.366'], ['D27.720.470.410'], ['E05.196.566'], ['D02.705'], ['D01.268.666'], ['E05.978.808'], ['D27.888.284.903.655']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Distinct development and functions of resident and recruited liver Kupffer cells/macrophages. | Although mouse liver F4/80(+) Kupffer cells consist of cytokine-producing CD11b(+) cells and phagocytic CD68(+) cells, an undefined CD11b(-) CD68(-) subset (30%) also exists. We herein demonstrate a more fundamental classification by adding CD32 (FcãRII), which covers most liver F4/80(+) cells and the distinct function... | ['Aged', 'Animals', 'Antigens, CD', 'Cell Line, Tumor', 'Female', 'Humans', 'Kupffer Cells', 'Liver Neoplasms', 'Male', 'Mice', 'Middle Aged', 'Staphylococcus aureus'] | 23,964,119 | [['M01.060.116.100'], ['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.372.588', 'A11.627.482.588', 'A11.733.397.588', 'A15.382.670.522.588', 'A15.382.680.397.588'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Follow-up of persons on long-term sick-leave. A cohort study in the city of Moss]. | Follow-up of people on long-term sickness leave has been a priority for central and local authorities for a number of years. In this study we have followed a cohort of such people from the city of Moss. We wanted to find out how many returned to work, and who these were. The cohort consisted of 1,975 persons. Median ag... | ['Adult', 'Cohort Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Insurance, Health', 'Male', 'Mental Disorders', 'Middle Aged', 'Musculoskeletal Diseases', 'Norway', 'Rehabilitation, Vocational', 'Sick Leave', 'Socioeconomic Factors'] | 7,998,036 | [['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', '... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene. | The phosphotyrosyl phosphatase activator (PTPA), a protein phosphatase 2A (PP2A) regulatory protein, specifically stimulates the phosphotyrosyl phosphatase activity of PP2A in vitro. Human PTPA is encoded by a single gene, the structure and chromosomal localization of which have been determined in our previous work. In... | ['Alternative Splicing', 'Amino Acid Sequence', 'Blotting, Northern', 'Blotting, Southern', 'Blotting, Western', 'Cell Line', 'DNA, Complementary', 'Dose-Response Relationship, Drug', 'Exons', 'Frameshift Mutation', 'Gene Library', 'Glutathione Transferase', 'Humans', 'Introns', 'Molecular Sequence Data', 'Phosphoprote... | 10,880,964 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Six-axis orthodontic force and moment sensing system for dentist technique training. | The purpose of this study is to develop a sensing system device that measures three-axis orthodontic forces and three-axis orthodontic moments for dentist training. The developed sensing system is composed of six-axis force sensors, action sticks, sliders, and tooth models. The developed system also simulates various t... | ['Biomechanical Phenomena', 'Dental Models', 'Dentists', 'Humans', 'Models, Biological', 'Orthodontics', 'Tooth'] | 28,268,769 | [['G01.154.090', 'G01.374.089'], ['E06.261', 'J01.897.280.500.545.129.200', 'L01.178.820.090.545.129.200'], ['M01.526.485.330', 'N02.360.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['E06.658', 'H02.163.876.439'], ['A14.549.167.860']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 |
Antiproliferative activity of king cobra (Ophiophagus hannah) venom L-amino acid oxidase. | King cobra (Ophiophagus hannah) venom L-amino acid oxidase (LAAO), a heat-stable enzyme, is an extremely potent antiproliferative agent against cancer cells when compared with LAAO isolated from other snake venoms. King cobra venom LAAO was shown to exhibit very strong antiproliferative activities against MCF-7 (human ... | ['Animals', 'Apoptosis', 'Caspase 3', 'Caspase 7', 'Cell Proliferation', 'Cell Survival', 'DNA Fragmentation', 'Elapid Venoms', 'Elapidae', 'Humans', 'Hydrogen Peroxide', 'L-Amino Acid Oxidase', 'MCF-7 Cells'] | 24,118,879 | [['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126.350.700', 'D08.811.277.656.300.200.126.350.700', 'D12.644.360.075.405.350.700', 'D12.776.476.075.405.350.700'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Prognostic analysis of clinicopathological factors in patients after radical resection of esophageal carcinoma]. | OBJECTIVE: To explore factors affecting the survival in patients after radical resection of esophageal carcinoma, and to provide a valuable reference for selecting treatment protocol after surgery.METHODS: Clinicopathological data of 618 esophageal cancer patients who underwent radical resection at the Fourth Hospital ... | ['Adenocarcinoma', 'Adult', 'Aged', 'Carcinoma, Small Cell', 'Carcinoma, Squamous Cell', 'Esophageal Neoplasms', 'Esophagectomy', 'Female', 'Humans', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Postoperative Care', 'Proportional Hazards Models', 'Radiotherapy, Adjuvant',... | 22,781,041 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200.380'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['E04.210.346'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.56... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Spectral parameters of heart rate variability in man under the acute normobaric hypoxia conditions]. | Spectral parameters (SP) of heart rate variability (HRV) and a duration of cardiointervals (RR) in 14 healthy male volunteers at the age of 23-36 years under the influence of acute normobaric hypoxia by respiratory gas oxygen-nitrogen mixture (9% O2, 25 min) were studied. The 300 cardiocycles at each of six experimenta... | ['Acute Disease', 'Adult', 'Electrocardiography', 'Heart Rate', 'Humans', 'Hypoxia', 'Male', 'Nitrogen', 'Oxygen'] | 25,868,331 | [['C23.550.291.125'], ['M01.060.116'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['D01.268.604', 'D01.362.625'], ['D01.268.185.550', 'D01.362.670']] | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lipoprotein N-acyl transferase (Lnt1) is dispensable for protein O-mannosylation by Streptomyces coelicolor. | A protein glycosylation system related to that for protein mannosylation in yeast is present in many actinomycetes. This system involves polyprenyl phosphate mannose synthase (Ppm), protein mannosyl transferase (Pmt), and lipoprotein N-acyl transferase (Lnt). In this study, we obtained a series of mutants in the ppm (s... | ['Acyltransferases', 'Bacterial Proteins', 'Genetic Complementation Test', 'Glycoproteins', 'Glycosylation', 'Lipoproteins', 'Mannose', 'Mannosyltransferases', 'Mycobacterium tuberculosis', 'Polyisoprenyl Phosphate Monosaccharides', 'Recombinant Fusion Proteins', 'Sequence Deletion', 'Species Specificity', 'Streptomyce... | 24,117,719 | [['D08.811.913.050'], ['D12.776.097'], ['E05.393.281.526'], ['D09.400.430', 'D12.776.395'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['D10.532', 'D12.776.521'], ['D09.947.875.359.588'], ['D08.811.913.400.450.560'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.552.552.702'], ['D02.455.849.690.700.700', 'D0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dissolution kinetics of a three-component solid I: ethylparaben, phenacetin, and salicylamide. | The dissolution rates of each component in compressed spheres consisting of three components were measured under sink conditions. A film diffusion model is discussed and presented diagrammatically to illustrate the 13 possible dissolution behaviors of a three-component solid. Experimental dissolution rates compare favo... | ['Kinetics', 'Models, Chemical', 'Parabens', 'Phenacetin', 'Salicylamides', 'Solubility', 'Spectrophotometry, Ultraviolet'] | 6,886,981 | [['G01.374.661', 'G02.111.490'], ['E05.599.495'], ['D02.241.223.100.300.460', 'D02.241.511.390.460', 'D02.455.426.559.389.127.281.460', 'D02.455.426.559.389.657.410.460'], ['D02.065.199.092.700', 'D02.092.146.113.092.700'], ['D02.065.793'], ['G02.805'], ['E05.196.712.726.802', 'E05.196.867.826.802']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
From image processing to classification: III. Matching patterns by shifting and stretching. | A method for the classification of electrophoretic patterns is described and tested on a data set representing ten wheat varieties. The method attempts to match each electropherogram to each variety by a transformation involving displacement and stretching along the x-axis. This is done essentially by the method of lea... | ['Algorithms', 'Isoelectric Focusing', 'Mathematics', 'Plant Proteins', 'Quality Control', 'Triticum'] | 8,529,602 | [['G17.035', 'L01.224.050'], ['E05.196.401.663', 'E05.301.300.663'], ['H01.548'], ['D12.776.765'], ['J01.897.608'], ['B01.650.940.800.575.912.250.822.918']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells. | This work investigates the role of NT-3 in peripheral myelination. Recent articles, based in vitro, propose that NT-3 acting through its high-affinity receptor TrkC may act to inhibit myelin formation by enhancing Schwann cell motility and/or migration. Here, we investigate this hypothesis in vivo by examining myelinat... | ['Animals', 'Animals, Newborn', 'Apoptosis', 'Axons', 'Caspase 3', 'Gene Expression Regulation, Developmental', 'Mice', 'Mice, Knockout', 'Microscopy, Electron, Transmission', 'Myelin P0 Protein', 'Myelin-Associated Glycoprotein', 'Nerve Growth Factors', 'Neurofilament Proteins', 'Peripheral Nerves', 'Schwann Cells', '... | 18,080,292 | [['B01.050'], ['B01.050.050.282'], ['G04.146.954.035'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['G05.308.310'], ['B01.050.150.900.649.313.992.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
An evaluation of electrical stimulation for improving periprosthetic attachment. | Transcutaneous osseointegrated implants (TOI) have been shown to improve functionality for patients with limb loss by allowing direct skeletal attachment between an exoprosthesis and host bone. However, a lengthy rehabilitation period has limited the expansion of TOI and may be accelerated with electrical stimulation. ... | ['Animals', 'Bone Regeneration', 'Bone Substitutes', 'Electric Stimulation', 'Female', 'Femur', 'Hindlimb', 'Rabbits'] | 21,381,193 | [['B01.050'], ['G11.427.213.140', 'G16.762.150.150'], ['D25.130.325', 'J01.637.051.130.325'], ['E05.723.402'], ['A02.835.232.043.150'], ['A13.473'], ['B01.050.150.900.649.313.968.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Peroperative evaluation of pulmonary vascular resistance by cavo-pulmonary bypass. Value of atrio- and cavo-pulmonary diversions]. | Immediate and long-term results of the Fontan procedure depend on the value of the pulmonary vascular resistance. This parameter cannot always be quantified accurately during preoperative evaluation. Cavo-pulmonary bypass using an extra corporeal circulation allowed simulation a Fontan procedure in 5 patients, and pred... | ['Anastomosis, Surgical', 'Child', 'Child, Preschool', 'Extracorporeal Circulation', 'Heart Defects, Congenital', 'Humans', 'Intraoperative Care', 'Pulmonary Artery', 'Pulmonary Veins', 'Vascular Resistance', 'Vena Cava, Superior'] | 1,530,397 | [['E04.035'], ['M01.060.406'], ['M01.060.406.448'], ['E04.292'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.731.400', 'E04.604.249', 'N02.421.585.722.400'], ['A07.015.114.715'], ['A07.015.908.713'], ['G09.330.380.921'], ['A07.015.908.949.815']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Inherently chiral uranyl-salophen macrocycles: computer-aided design and resolution. | [structure: see text] A flipping motion rapidly inverts the bent structure of uranyl-salophen compounds and, consequently, causes fast enantiomerization of nonsymmetrically substituted derivatives. This process has been previously slowed by introducing bulky substituents in the imine bond region. Since the resulting co... | ['Computer-Aided Design', 'Crystallography, X-Ray', 'Macrocyclic Compounds', 'Models, Molecular', 'Molecular Structure', 'Organometallic Compounds', 'Salicylates', 'Stereoisomerism', 'Time Factors'] | 16,292,810 | [['L01.224.108.150', 'L01.296.110.150'], ['E05.196.309.742.225'], ['D04.345'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['D02.691'], ['D02.241.223.100.300.595', 'D02.241.511.390.595', 'D02.455.426.559.389.127.281.595', 'D02.455.426.559.389.657.410.595'], ['G02.607.445.682'], ['G01.910.857']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Superactive octapeptide somatostatin analogs containing tryptophan at position 1. | We synthesized a series of octapeptide analogs of somatostatin, containing N-terminal tryptophan or another amino acid followed by the hexapeptide sequences Cys-Phe-D-Trp-Lys-Thr-Cys or Cys-Tyr-D-Trp-Lys-Val-Cys and a C-terminal threoninamide or tryptophanamide. After purification by HPLC, the inhibitory activities of ... | ['Animals', 'Growth Hormone', 'Indicators and Reagents', 'Male', 'Oligopeptides', 'Peptides, Cyclic', 'Rats', 'Rats, Inbred Strains', 'Somatostatin', 'Structure-Activity Relationship'] | 2,882,520 | [['B01.050'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['D27.720.470.410'], ['D12.644.456'], ['D04.345.566', 'D12.644.641'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D06.472.699.327.700.875', 'D06.472.699.587.780', 'D12.644... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development. | A-kinase anchoring proteins (AKAPs) bind the regulatory subunits of protein kinase A (PKA) and localize the holoenzyme to discrete signaling microdomains in multiple subcellular compartments. Despite emerging evidence for a nuclear pool of PKA that rapidly responds to activation of the PKA signaling cascade, only a few... | ['Amino Acid Sequence', 'Animals', 'Carrier Proteins', 'Female', 'Heart', 'Humans', 'Immunoprecipitation', 'Microscopy, Confocal', 'Microscopy, Fluorescence', 'Molecular Sequence Data', 'Myocardium', 'Nuclear Proteins', 'Phosphorylation', 'Pregnancy', 'Rats', 'Rats, Sprague-Dawley', 'Reverse Transcriptase Polymerase Ch... | 23,071,553 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.157'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.150.639', 'E05.478.605'], ['E01.370.350.515.395', 'E05.595.395'], ['E01.370.350.515.458', 'E05.595.458'], ['L01.453.245.667'], ['A02.633.580', 'A07.541.704', 'A10.690.552.75... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A comparison of fluticasone propionate, 1 mg daily, with beclomethasone dipropionate, 2 mg daily, in the treatment of severe asthma. International Study Group. | We wanted to compare the efficacy and safety of fluticasone propionate, a new topically active inhaled corticosteroid, to that of high dose beclomethasone dipropionate, in severe adult asthma. Patients currently receiving between 1.5-2.0 mg.day-1 of an inhaled corticosteroid were treated for six weeks in a double-blind... | ['Administration, Topical', 'Adolescent', 'Adult', 'Aged', 'Androstadienes', 'Anti-Inflammatory Agents', 'Asthma', 'Beclomethasone', 'Chronic Disease', 'Double-Blind Method', 'Female', 'Fluticasone', 'Forced Expiratory Volume', 'Glucocorticoids', 'Humans', 'Male', 'Middle Aged', 'Peak Expiratory Flow Rate', 'Vital Capa... | 8,339,809 | [['E02.319.267.120'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D04.210.500.054.079.129'], ['D27.505.954.158'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['D04.210.500.745.432.769.125', 'D04.210.500.883.154'], ['C23.550.291.500'], ['E05.318.370.300', 'E05.581.500.300', 'N0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
177Lu-AMBA biodistribution, radiotherapeutic efficacy, imaging, and autoradiography in prostate cancer models with low GRP-R expression. | UNLABELLED: (177)Lu-DO3A-CH(2)CO-G-4-aminobenzoyl-Q-W-A-V-G-H-L-M-NH(2) ((177)Lu-AMBA) is a radiolabeled bombesin derivative that is bound and internalized by cells expressing the G-protein-coupled gastrin-releasing peptide receptor (GRP-R) and is currently in phase I clinical trials. In previous radiotherapy studies w... | ['Amino Acid Sequence', 'Animals', 'Autoradiography', 'Cell Line, Tumor', 'Cell Transformation, Neoplastic', 'Disease Models, Animal', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Immunohistochemistry', 'Male', 'Mice', 'Neoplasm Metastasis', 'Oligopeptides', 'Prostatic Neoplasms', 'Radiometry', 'Radionuclide Im... | 19,910,427 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['A11.251.210.190', 'A11.251.860.180'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants. | Trypanosomal all-alpha dUTPases are homodimeric enzymes that catalyze the hydrolysis of dUTP and dUDP to dUMP and PPi. Trypanosomes lack dCTP/dCMP deaminase and therefore strongly depend on dUDP/dUTP hydrolysis for dUMP production. Here we have addressed by gene replacement the consequences of elimination of dUTPase ac... | ['Cell Survival', 'Gene Knockout Techniques', 'Pyrimidines', 'Pyrophosphatases', 'Trypanosoma brucei brucei'] | 23,201,394 | [['G04.346'], ['E05.393.335.750'], ['D03.383.742'], ['D08.811.277.040.600'], ['B01.268.475.868.887.080']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sofosbuvir and daclatasvir combination therapy in a liver transplant recipient with severe recurrent cholestatic hepatitis C. | Recurrent HCV infection following liver transplantation can lead to accelerated allograft injury that is difficult to treat with interferon. The aim of this study is to describe the first ever use of an interferon-free, all oral regimen in a liver transplant recipient with severe recurrent HCV. A 54-year-old male with ... | ['Cholestasis', 'Dose-Response Relationship, Drug', 'Drug Therapy, Combination', 'Follow-Up Studies', 'Hepacivirus', 'Hepatitis C, Chronic', 'Humans', 'Imidazoles', 'Liver Transplantation', 'Male', 'Middle Aged', 'RNA, Viral', 'Recurrence', 'Sofosbuvir', 'Transplantation, Homologous', 'Uridine Monophosphate'] | 23,593,993 | [['C06.130.120.135'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.310'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.380.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expandable metal stents in the palliation of malignant dysphagia and oesophageal-respiratory fistulae. | The use of self expandable metal stents in the palliation of malignant dysphagia and oesophago-respiratory fistulae has increased in recent years. The aim of this study was to report a comprehensive 4 year audit of a Specialist Unit's experience with the expandable stent. 200 expandable metal stents were deployed for p... | ['Aged', 'Aged, 80 and over', 'Deglutition Disorders', 'Esophageal Fistula', 'Esophageal Neoplasms', 'Female', 'Humans', 'Male', 'Middle Aged', 'Palliative Care', 'Respiratory Tract Fistula', 'Stents', 'Treatment Outcome'] | 11,820,518 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C06.405.117.119', 'C09.775.174'], ['C06.267.250', 'C06.405.117.367', 'C23.300.575.185.250'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.7... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Freedom to innovate. | Clinicians discuss the benefits and challenges of the community foundation trust model for delivering healthcare services in England. | ['Attitude of Health Personnel', 'Community Health Nursing', 'Decision Making, Organizational', 'England', 'Entrepreneurship', 'Foundations', 'Humans', 'Models, Nursing', 'Nurse Administrators', 'Patient Discharge', 'State Medicine'] | 21,309,428 | [['F01.100.050', 'N05.300.100'], ['H02.478.676.150', 'N02.421.143.150'], ['N04.452.190'], ['Z01.542.363.300'], ['J01.219.375', 'N04.452.610.250'], ['N03.219.483.311', 'N03.540.630.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.645'], ['M01.526.070.670', 'M01.526.485.650.580', 'N02.360.650.580'], ['E0... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
A prospective study of the LMB regimen for diffuse large cell non Hodgkin's lymphoma in adults. | Although the CHOP regimen remains a standard first line chemotherapy for diffuse large cell lymphoma (DLCL) in adults, a majority of these patients will still experience disease progression after the completion of this treatment. The LMB protocol is an intensive chemotherapy regimen which yields high survival rates in ... | ['Adult', 'Antineoplastic Combined Chemotherapy Protocols', 'Cyclophosphamide', 'Cytarabine', 'Disease-Free Survival', 'Female', 'Humans', 'Lymphoma, Large B-Cell, Diffuse', 'Male', 'Methotrexate', 'Middle Aged', 'Prospective Studies', 'Survival Analysis'] | 10,784,397 | [['M01.060.116'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.75... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cannabinoid 1 receptor blockade in the dorsal hippocampus prevents the reinstatement but not acquisition of morphine-induced conditioned place preference in rats. | The cannabinoid 1 receptors (CB1Rs) signaling is strongly linked to conditioned rewarding effects of opiates. Learned associations between environmental contexts and discrete cues and drug use play an important role in the maintenance and/or relapse of morphine addiction. Although previous studies suggest that context-... | ['Animals', 'Blotting, Western', 'Cannabinoid Receptor Antagonists', 'Cerebral Cortex', 'Conditioning, Psychological', 'Extinction, Psychological', 'Gene Expression', 'Hippocampus', 'Male', 'Microinjections', 'Morphine', 'Narcotics', 'Piperidines', 'Pyrazoles', 'Random Allocation', 'Rats, Sprague-Dawley', 'Receptor, Ca... | 28,492,416 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D27.505.519.625.085.750', 'D27.505.696.399.472.188.750'], ['A08.186.211.200.885.287.500'], ['F02.463.425.179'], ['F02.463.425.770.232'], ['G05.297'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Concentrations of cefazolin sodium in ischemic extremities. | Patients with ischemic extremities were administered 2 g of cefazolin sodium (CEZ) intravenously from the unaffected extremity. Blood samples were periodically taken from both affected and unaffected extremities and concentrations of CEZ in both samples were compared. No statistically significant difference was observe... | ['Adult', 'Aged', 'Bacteria', 'Cefazolin', 'Extremities', 'Humans', 'Ischemia', 'Male', 'Middle Aged'] | 6,668,974 | [['M01.060.116'], ['M01.060.116.100'], ['B03'], ['D02.065.589.099.249.160', 'D02.886.665.074.160', 'D03.633.100.300.249.160'], ['A01.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.513'], ['M01.060.116.630']] | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Genotypic resistance profile in treatment-experienced HIV-infected individuals after abacavir and efavirenz salvage regimen. | Once highly active antiretroviral therapy (HAART) fails to suppress HIV replication and resistant viruses emerge, it is difficult to find a salvage regimen since cross-resistance is high among the available classes of antiretroviral drugs. In this retrospective analysis, genotypic resistance profiles were analysed in 2... | ['Alkynes', 'Anti-HIV Agents', 'Antiretroviral Therapy, Highly Active', 'Benzoxazines', 'Cyclopropanes', 'Dideoxynucleosides', 'Drug Resistance, Viral', 'Genotype', 'HIV Infections', 'HIV Protease', 'HIV Reverse Transcriptase', 'HIV-1', 'Humans', 'Mutation', 'Oxazines', 'Salvage Therapy', 'Time Factors'] | 14,670,587 | [['D02.455.326.397'], ['D27.505.954.122.388.077.088'], ['E02.319.310.075'], ['D03.383.533.249', 'D03.633.100.209'], ['D02.455.426.392.368.533'], ['D13.570.230.500'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['G05.380'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Confounders in the detection of minimal hepatic encephalopathy: a neuropsychological and quantified EEG study. | BACKGROUND & AIMS: Chronic alcohol misuse, HCV infection and cirrhosis may cause cognitive alterations. The aim of the present study was to assess the influence of alcohol misuse, HCV infection and cirrhosis per se on the neuropsychological and electroencephalogram (EEG) profile and to evaluate the role of alcohol misu... | ['Adult', 'Alcoholism', 'Cognition Disorders', 'Confounding Factors, Epidemiologic', 'Electroencephalography', 'Female', 'Hepatic Encephalopathy', 'Hepatitis C, Chronic', 'Humans', 'Liver Cirrhosis', 'Liver Cirrhosis, Alcoholic', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Psychometrics'] | 25,040,245 | [['M01.060.116'], ['C25.775.100.250', 'F03.900.100.350'], ['F03.615.250'], ['N05.715.350.240', 'N06.850.490.718'], ['E01.370.376.300', 'E01.370.405.245'], ['C06.552.308.500.356', 'C10.228.140.163.360', 'C18.452.132.360'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', '... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Current status and development of monitoring on adverse reaction of traditional Chinese medicine in China]. | With the wide usage of traditional Chinese medicine (TCM) and the diversity of its dosage-forms, the reports about adverse reaction (ADR) caused by TCM were gradually increased. As the cradle of TCM with tremendous manufacturing enterprise engaged for this purpose, to establish and perfect the TCM ADR monitoring is the... | ['Adverse Drug Reaction Reporting Systems', 'China', 'Drug Contamination', 'Drug Interactions', 'Drugs, Chinese Herbal', 'Humans', 'Legislation, Drug', 'Medicine, Chinese Traditional'] | 16,089,130 | [['E05.337.800.120', 'N02.421.668.320.120'], ['Z01.252.474.164'], ['N06.850.360'], ['G07.690.773.968'], ['D20.215.784.500.350', 'D26.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.605', 'N03.706.615.402'], ['E02.190.488.585.520', 'I01.076.201.450.654.558.520']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Immortalization of Syrian hamster embryo cells: probabilistic event or deterministic process. | Previous findings on the induction of immortalization in SHE cells have been explained with the activation/alteration hypothesis which postulates that treatment with a carcinogen results in the induction of a so-called "activated state" which enhances the rate of a probabilistic event in the progeny of the treated cell... | ['Animals', 'Benzo(a)pyrene', 'Cell Count', 'Cell Cycle', 'Cell Division', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Cellular Senescence', 'Cricetinae', 'Culture Techniques', 'Embryo, Mammalian', 'Kinetics', 'Mesocricetus', 'Models, Biological', 'Tetradecanoylphorbol Acetate', 'Time Factors'] | 8,402,664 | [['B01.050'], ['D02.455.426.559.847.799.306.300', 'D04.615.799.306.300'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.144'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['G04.043'], ['B01.050.150.900.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Organization and results of surgical care for ulcerative gastroduodenal bleeding in the hospitals of Central Federal District]. | AIM: To present treatment of 52 149 patients with ulcerative gastroduodenal bleeding (UGDB) who were treated in different regions of Central Federal District (CFD) for the period 2011-2014. It is noted that UGDB incidence per 100 thousands is increased proportionally from 32.9 to 77.8 according to population less than ... | ['Endoscopy, Gastrointestinal', 'Health Services Needs and Demand', 'Hemostasis, Surgical', 'Hospitals', 'Humans', 'Mortality', 'Peptic Ulcer Hemorrhage', 'Russia'] | 28,303,867 | [['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['N03.349.380.420', 'N05.300.450'], ['E02.520.490', 'E04.350'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Extreme individual flexibility of heterothermy in free-ranging Malagasy mouse lemurs (Microcebus griseorufus). | Flexibility in physiological processes is essential to adequately respond to changes in environmental conditions. Madagascar is a particularly challenging environment because climatic conditions seem less predictable than in comparative ecosystems in other parts of the world. We used the reddish-gray mouse lemur (Micro... | ['Adipose Tissue', 'Animals', 'Body Temperature Regulation', 'Cheirogaleidae', 'Climate', 'Ecosystem', 'Energy Metabolism', 'Hibernation', 'Mice', 'Rain', 'Temperature', 'Time Factors'] | 20,717,683 | [['A10.165.114'], ['B01.050'], ['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['B01.050.150.900.649.313.988.700.200'], ['G16.500.275.071', 'N06.230.300.100.250'], ['G16.500.275.157', 'N06.230.124'], ['G03.295'], ['G07.110.232.889.500', 'G07.410.421.889.500', 'G16.012.500.535.889.500'], ['B01.050.150.900.649.313.992... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Development of a new nomogram to predict insignificant prostate cancer in patients undergoing radical prostatectomy. | OBJECTIVE: The aim of this study was to develop a nomogram to predict the probability of insignificant prostate cancer.MATERIALS AND METHODS: A retrospective analysis was conducted of patients who underwent radical prostatectomy at a Korean hospital between January 2005 and December 2014. Patients with pathologically i... | ['Aged', 'Biopsy, Large-Core Needle', 'Humans', 'Kallikreins', 'Logistic Models', 'Magnetic Resonance Imaging', 'Male', 'Margins of Excision', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Grading', 'Neoplasm Staging', 'Nomograms', 'Organ Size', 'Prognosis', 'Prostate', 'Prostate-Specific Antigen', 'Prostatectomy',... | 28,168,924 | [['M01.060.116.100'], ['E01.370.225.500.384.100.119.750', 'E01.370.225.998.054.119.750', 'E01.370.388.100.100.750', 'E04.074.119.750', 'E04.665.100.750', 'E05.200.500.384.100.119.750', 'E05.200.998.054.119.750', 'E05.242.384.100.119.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.656.300.760.442',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
NMR characterization of three forms of ferredoxin from Desulphovibrio gigas, a sulphate reducer. | A NMR and magnetic susceptibility study of the oxidized and reduced states of three different oligomers (forms) of a [4Fe-4S] ferrodoxin protein from Desulphovibrio gigas, FdI, FdI', and FdII was carried out. FdI and FdI' are different trimers and FdII a tetramer of the same basic subunit. A probable assignment of the ... | ['Desulfovibrio', 'Ferredoxins', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Mathematics', 'Oxidation-Reduction', 'Protein Conformation', 'Temperature'] | 836,818 | [['B03.440.425.410.350', 'B03.660.125.144.500.875', 'B03.900.350'], ['D12.776.097.350', 'D12.776.157.427.374.375.275', 'D12.776.556.579.374.375.275', 'D12.776.765.319'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['H01.548'], ['G02.700', 'G03.295.531'], ['G02.111.570.820.709'], ['G01.906.595', 'G16.500.275.06... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Comparability of size measurements of the pancreas in magnetic resonance imaging and transabdominal ultrasound. | INTRODUCTION: Transabdominal ultrasound (US) and magnetic resonance imaging (MRI) are commonly used for the examination of the pancreas in clinical routine. We therefore were interested in the concordance of these two imaging methods for the size measurement of the pancreas and how age, gender, and body mass index (BMI... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Observer Variation', 'Organ Size', 'Pancreas', 'Reproducibility of Results', 'Ultrasonography'] | 31,883,163 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Is pleasantness of biscuits and cakes related to their actual or to their perceived sugar and fat contents? | Perceptions of sugar, fat and moisture contents, as well as their influences on pleasantness were investigated in commercial foods. One-hundred-and-two-normal-weight men rated the "pleasantness", "flavour intensity", "moisture", "sweetness" and "fatness" of 39 different biscuits and cakes. Sugar content was accurately ... | ['Adolescent', 'Adult', 'Dietary Fats', 'Dietary Sucrose', 'Food', 'Humans', 'Male', 'Perception', 'Regression Analysis', 'Taste', 'Water'] | 9,632,461 | [['M01.060.057'], ['M01.060.116'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D09.301.831.250', 'D09.698.629.305.770.200', 'D09.947.500.250', 'D09.947.750.770.200', 'D27.720.372.300.353.609.750.250', 'G07.203.300.362.831.250', 'G07.203.300.514.500.400.700.750.250', 'J02.500.362.831.250', 'J02.500.514.500.400.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Drug interaction and pharmacokinetic modeling of oxcarbazepine in korean patients with epilepsy. | OBJECTIVES: To determine first whether there was a clear relationship between concentrations of the active metabolite of oxcarbazepine (OXC), 10-hydroxycarbamazepine (OHC), and dose adjusted for weight, and second, whether the clearance of OHC was influenced by comedication with enzyme-inducing antiepileptic drugs (EIA... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anticonvulsants', 'Carbamazepine', 'Child', 'Child, Preschool', 'Chromatography, High Pressure Liquid', 'Dose-Response Relationship, Drug', 'Drug Interactions', 'Drug Monitoring', 'Drug Therapy, Combination', 'Epilepsy', 'Female', 'Humans', 'Male', 'Middle Aged', 'O... | 22,246,398 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.427.080'], ['D03.633.300.240.127'], ['M01.060.406'], ['M01.060.406.448'], ['E05.196.181.400.300'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.968'], ['E01.370.520.200'], ['E02.319.310'], ['C10.228.140.490'], ['B01.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Local immune response in the chicken Harderian gland to antigen given by different ocular routes. | The effectiveness of three ocular routes of antigen administration to produce a local immune response in the Harderian gland was studied. The routes were by eyedrop, injection into the ocular conjunctiva and injection into the nictitating membrane. The antigen was observed in the cytoplasm of macrophages located within... | ['Animals', 'Carbon', 'Chickens', 'Coloring Agents', 'Conjunctiva', 'Harderian Gland', 'Hemolytic Plaque Technique', 'Horseradish Peroxidase', 'Injections', 'Nictitating Membrane', 'O Antigens', 'Ophthalmic Solutions', 'Polysaccharides, Bacterial'] | 1,372,749 | [['B01.050'], ['D01.268.150'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D27.720.233'], ['A09.371.060.200', 'A09.371.337.168'], ['A13.445'], ['E01.370.225.812.375', 'E05.200.812.375', 'E05.478.594.375'], ['D08.811.682.732.512'], ['E02.319.267.530'], ['A13.660'], ['D09.698.718.450.600', 'D10.494.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of buffered lidocaine in bone marrow biopsies: a randomized, controlled trial. | PURPOSE/OBJECTIVES: To determine whether a difference exists in perceived pain during preprocedure anesthetic injection for bone marrow biopsy between buffered and unbuffered lidocaine, to determine whether pain levels change over time, and to investigate relationships between perceived pain scores and other variables.... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anesthetics, Local', 'Biopsy', 'Bone Marrow Examination', 'Buffers', 'Cross-Over Studies', 'Double-Blind Method', 'Female', 'Hematologic Neoplasms', 'Humans', 'Lidocaine', 'Male', 'Middle Aged', 'Pain', 'Pain Measurement', 'Sodium Bicarbonate', 'Young Adult'] | 19,136,338 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.370.225.625.135', 'E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Feasibility of Routine Assessment of Exercise Knowledge and Safety in Youth With Type 1 Diabetes. | PURPOSE: This pilot study assessed the feasibility and satisfaction of an electronic clinical tool to survey management of exercise in youth with type 1 diabetes (T1DM) for use in an outpatient diabetes clinic setting.METHODS: Fifty youth with T1DM were recruited (ages, 10-18 years; mean ± SD, 14.8 ± 2.4) and 11 diabet... | ['Adolescent', 'Child', 'Diabetes Mellitus, Type 1', 'Exercise', 'Exercise Therapy', 'Feasibility Studies', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Internet-Based Intervention', 'Male', 'Patient Education as Topic', 'Pilot Projects'] | 31,244,377 | [['M01.060.057'], ['M01.060.406'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['G11.427.410.698.277', 'I03.350'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Stromal cells in myeloid and lymphoid long-term bone marrow cultures can support multiple hemopoietic lineages and modulate their production of hemopoietic growth factors. | Hemopoiesis in long-term bone marrow cultures (LTBMC) is dependent on adherent stromal cells that form an in vitro hemopoietic microenvironment. Myeloid bone marrow cultures (MBMC) are optimal for myelopoiesis, while lymphoid bone marrow cultures (LBMC) only support B lymphopoiesis. The experiments reported here have m... | ['Animals', 'B-Lymphocytes', 'Bone Marrow', 'Bone Marrow Cells', 'Cells, Cultured', 'Colony-Forming Units Assay', 'Growth Substances', 'Hematopoiesis', 'Hematopoietic Stem Cells', 'Lymphocytes', 'Mice', 'Time Factors'] | 3,490,887 | [['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A15.382.216'], ['A11.148', 'A15.378.316'], ['A11.251'], ['E01.370.225.500.383', 'E05.200.500.383', 'E05.242.383'], ['D27.505.696.377'], ['G04.152.825', 'G09.188.343'], ['A11.148.378',... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Abdominal manifestations of cystic fibrosis in older children and adults. | OBJECTIVE: Cystic fibrosis (CF) is a disorder of exocrine gland function of which the gene mutation has been existing for thousands of years. With recent medical advances, neonates presently affected have a life expectancy of 40 years. The common gastrointestinal presentations of CF patients, including pancreatic, hepa... | ['Adolescent', 'Adult', 'Biliary Tract Diseases', 'Child', 'Cystic Fibrosis', 'Female', 'Humans', 'Intestinal Diseases', 'Liver Diseases', 'Male', 'Pancreatic Diseases', 'Radiography, Abdominal', 'Tomography, X-Ray Computed'] | 17,056,906 | [['M01.060.057'], ['M01.060.116'], ['C06.130'], ['M01.060.406'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469'], ['C06.552'], ['C06.689'], ['E01.370.350.700.715'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Ultrasound of the Achilles tendon after surgical repair: morphology and function. | Ultrasound is a well established method for the examination of the Achilles tendon. The objective of the study was to provide answers to the following questions: What ultrasonographic structural changes are long lasting after surgical repair? How important is ultrasound with regards to the functional evaluation of late... | ['Achilles Tendon', 'Adult', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Postoperative Period', 'Rupture', 'Treatment Outcome', 'Ultrasonography'] | 7,788,228 | [['A02.880.176'], ['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.614.750', 'N02.421.585.753.750'], ['C26.761'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['E0... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection. | LKM-1 antibody, which characterizes a subtype of autoimmune hepatitis (AIH), is also found in some patients with chronic hepatitis C virus (HCV) infection. It has been suggested that HCV initiates autoimmunity through molecular mimicry, because there is partial identity between HCV and cytochrome P4502D6 (CYP2D6), the ... | ['Adolescent', 'Adult', 'Aged', 'Antibody Specificity', 'Autoantibodies', 'Autoantigens', 'Autoimmune Diseases', 'B-Lymphocytes', 'Child', 'Child, Preschool', 'Cytochrome P-450 CYP2D6', 'Cytochrome P-450 Enzyme System', 'Female', 'Hepatitis', 'Hepatitis C', 'Hepatitis, Chronic', 'Humans', 'Infant', 'Male', 'Middle Aged... | 8,033,426 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G12.100'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D23.050.422'], ['C20.111'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['M01... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of estrogen on isoforms of nitric oxide synthase: possible mechanism of anti-atherosclerotic effect of estrogen. | While estrogen is known to prevent the development of atherosclerosis, the mechanism is not completely understood. We investigated the effects of superoxide dismutase, acetylcholine, and other compounds on the release of nitric oxide (NO) by measuring the relaxation responses of aortic rings, with and without intact en... | ['Animals', 'Aorta', 'Arteriosclerosis', 'Calmodulin', 'Cattle', 'Cells, Cultured', 'Cholesterol, Dietary', 'Cholesterol, HDL', 'Endothelium, Vascular', 'Estradiol', 'Female', 'Humans', 'Isoenzymes', 'Male', 'Nitric Oxide Synthase', 'Organ Culture Techniques', 'Progesterone', 'Rabbits', 'Sex Characteristics', 'Testoste... | 9,187,936 | [['B01.050'], ['A07.015.114.056'], ['C14.907.137.126'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['D04.210.500.247.808.197.225', 'D10.212.302.347', 'D10.570.938.208.222'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
18F-FDG uptake for prediction EGFR mutation status in non-small cell lung cancer. | Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) are a response to EGFR-tyrosine kinase inhibitor. However, a lack of sufficient tumor tissue has been a limitation for determining EGFR mutation status in clinical practice. The objective of this study was to predict EGFR mutation s... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Non-Small-Cell Lung', 'DNA Mutational Analysis', 'ErbB Receptors', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'Logistic Models', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Positron Emission Tomography Computed Tomography', 'Predictive Value of Tes... | 27,472,739 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['E05.393.760.700.300'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['D09.254.229.500'], ['B01.050.150.900.649.31... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Direct and indirect effects of interdental hygiene in a clinical trial. | Many randomized controlled trials (RCTs) in dental research test the efficacy of interventions on more than one outcome variable. Univariate methods, such as the t test or analysis of covariance, cannot evaluate the efficacy of interventions on multiple outcomes simultaneously. The aim of this study was to use structur... | ['Chi-Square Distribution', 'Dental Devices, Home Care', 'Dental Plaque', 'Dental Plaque Index', 'Gingivitis', 'Humans', 'Microscopy, Electron, Scanning', 'Models, Statistical', 'Multivariate Analysis', 'Oral Hygiene', 'Periodontal Index', 'Periodontal Pocket', 'Regression Analysis', 'Smoking', 'Toothbrushing', 'Treatm... | 18,946,011 | [['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E06.186.250', 'E06.761.726.292', 'E07.222.250'], ['C07.793.208.377'], ['E05.318.308.980.438.300.300', 'E06.208.250', 'N05.715.360.300.800.438.300.325', 'N06.850.520.308.980.438.300.300', 'N06.890.160.090'], ['C01.408', 'C07... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. | OBJECTIVE: This study investigated whether the functional abnormalities in prefrontal systems observed in adult bipolar disorder are manifested in adolescents with this illness.METHOD: Ten adolescents with bipolar disorder and 10 healthy comparison subjects participated in a color-naming Stroop task during event-relate... | ['Adolescent', 'Age Factors', 'Basal Ganglia', 'Bipolar Disorder', 'Child', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Neural Pathways', 'Neuropsychological Tests', 'Prefrontal Cortex'] | 12,832,254 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['A08.186.211.200.885.287.249'], ['F03.084.500'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['A08.612'], ['F04.711.513'], ['A08.186.211.200.885.287.500.270.700']] | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hemiconvulsion-hemiplegia syndrome in a patient with severe myoclonic epilepsy in infancy. | We report a 2-year-old girl who had repeated febrile or afebrile seizures since infancy. Prolonged left/right hemiconvulsions and myoclonus of the eyelids/extremities with generalization to tonic-clonic seizures, were refractory to antiepileptic agents. At age 1 year and 4 months, she contracted rotavirus infection, an... | ['Brain', 'Child, Preschool', 'DNA Mutational Analysis', 'Epilepsies, Myoclonic', 'Female', 'Functional Laterality', 'Hemiplegia', 'Humans', 'Magnetic Resonance Imaging', 'Mutation', 'NAV1.1 Voltage-Gated Sodium Channel', 'Nerve Tissue Proteins', 'Seizures', 'Seizures, Febrile', 'Sodium Channels', 'Syndrome'] | 19,563,349 | [['A08.186.211'], ['M01.060.406.448'], ['E05.393.760.700.300'], ['C10.228.140.490.375.130', 'C10.228.140.490.493.063'], ['F02.830.297.425', 'G11.561.225.425'], ['C10.597.622.295', 'C23.888.592.636.312'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['G05.365.590'], ['D12.776.157.530.400.875... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hyperactive boys almost grown up. V. Replication of psychiatric status. | We previously reported a prospective follow-up study of 101 young adult males whose conditions had been diagnosed as hyperactivity in childhood. Compared with controls, probands had significantly higher rates of attention-deficit, antisocial, and drug use disorders at follow-up (mean age, 18 years). The present study w... | ['Adolescent', 'Age Factors', 'Alcoholism', 'Antisocial Personality Disorder', 'Attention Deficit Disorder with Hyperactivity', 'Child', 'Child Behavior Disorders', 'Child, Preschool', 'Comorbidity', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Male', 'Mental Disorders', 'Prevalence', 'Psychiatric Status Rating ... | 1,984,764 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['C25.775.100.250', 'F03.900.100.350'], ['F03.675.050'], ['F03.625.094.150'], ['M01.060.406'], ['F03.625.141'], ['M01.060.406.448'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350']... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of acid inhibition on gastric endocrine cells. | There is increasing evidence that the numbers of antral G cells and of fundic argyrophil (ECL) cells are influenced by agents that inhibit gastric acid secretion. Antral G cells increase in states of achlorhydria in man and animals provided atrophic antral gastritis is absent. In rats, treatment with substituted benzim... | ['Animals', 'Antacids', 'Benzimidazoles', 'Dogs', 'Female', 'Gastric Acid', 'Gastric Fundus', 'Gastric Mucosa', 'Gastrins', 'Humans', 'Pyloric Antrum', 'Rats'] | 3,469,736 | [['B01.050'], ['D27.505.519.170', 'D27.505.954.483.080'], ['D03.633.100.103'], ['B01.050.150.900.649.313.750.250.216.200'], ['A12.200.307.603'], ['A03.556.875.875.419'], ['A03.556.875.875.440', 'A10.615.550.291'], ['D06.472.317.413', 'D06.472.699.280', 'D12.644.400.320', 'D12.644.548.280', 'D12.776.631.650.320'], ['B01... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Do emergency physicians and radiologists reliably interpret pelvic radiographs obtained as part of a trauma series? | INTRODUCTION: Interpretation of pelvic radiography is an important component of the primary survey and is commonly performed by emergency physicians. Radiologists bring unique skills to trauma care, including choice of imaging modality and image interpretation. It is not clear if this limited resource is most efficient... | ['Emergency Medicine', 'Emergency Service, Hospital', 'Hip Fractures', 'Humans', 'Prospective Studies', 'Radiography', 'Radiology', 'Sensitivity and Specificity'] | 22,411,598 | [['H02.403.250'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['C26.404.061.425', 'C26.531.750', 'C26.558.276.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.350.700'], ['H02.403.7... | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Protein tyrosine phosphorylation triggered by human Fc gamma RII. | The role of the cytoplasmic domain of human Fc gamma RII in cellular activation was studied by transfecting P815 cells with different isoforms or deletion mutants of this receptor and then assaying protein tyrosine phosphorylation after crosslinking with anti-CD32 monoclonal antibodies. Fc gamma RIIa, but not Fc gamma ... | ['Amino Acid Sequence', 'Animals', 'Antibodies, Monoclonal', 'Antigens, CD', 'B-Lymphocytes', 'Blotting, Western', 'Cell Line', 'Humans', 'Molecular Sequence Data', 'Monocytes', 'Phosphoproteins', 'Phosphorylation', 'Phosphotyrosine', 'Receptors, IgG', 'Recombinant Proteins', 'Transfection', 'Tyrosine'] | 7,516,160 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301.264.035', 'D23.101.100.110'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Glycemic Variability Is a Powerful Independent Predictive Factor of Midterm Major Adverse Cardiac Events in Patients With Diabetes With Acute Coronary Syndrome. | OBJECTIVE: Acute glucose fluctuations are associated with hypoglycemia and are emerging risk factors for cardiovascular outcomes. However, the relationship between glycemic variability (GV) and the occurrence of midterm major cardiovascular events (MACE) in patients with diabetes remains unclear. This study investigate... | ['Acute Coronary Syndrome', 'Blood Glucose', 'Cardiovascular Diseases', 'Diabetes Complications', 'Diabetes Mellitus', 'Hospitalization', 'Humans', 'Percutaneous Coronary Intervention', 'Prognosis', 'Registries', 'Risk Factors'] | 30,728,222 | [['C14.280.647.124', 'C14.907.585.124'], ['D09.947.875.359.448.500'], ['C14'], ['C19.246.099'], ['C18.452.394.750', 'C19.246'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.100.814.529.968', 'E04.502.382.968'], ['E01.789'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.36... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Loop formation of Meckel's diverticulum causing small bowel obstruction in adults: report of two cases. | Meckel's diverticulum is the most common congenital anomaly of the gastrointestinal tract, and in the majority of cases it remains asymptomatic. The total lifetime rate of complications is 4%. It is an uncommon cause of intestinal obstruction in adults. Loop formation of Meckel's diverticulum leading to small bowel obs... | ['Adult', 'Humans', 'Intestinal Obstruction', 'Male', 'Meckel Diverticulum', 'Radiography'] | 22,290,014 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.531'], ['A03.556.124.684.249.612', 'A03.556.249.124.612', 'C06.198.859', 'C06.405.205.282.750.750', 'C16.131.314.556', 'C23.300.415.750'], ['E01.370.350.700']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Vestibular projections to the temporal cortex in the cat]. | The exact borders of vestibular nerve projections in the temporal cortex of cat were investigated under chloralose-nembutal and chloralose anesthetics. The caudal border of the vestibular area coincided with the anterior ectosylvian gyrus. The focus of evoked potentials was located in the anterior suprasylvian sulcus o... | ['Afferent Pathways', 'Animals', 'Brain Mapping', 'Cats', 'Evoked Potentials', 'Medulla Oblongata', 'Pons', 'Reaction Time', 'Temporal Lobe', 'Vestibular Nerve'] | 6,855,975 | [['A08.612.220'], ['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['G07.265.216.500', 'G11.561.200.500'], ['A08.186.211.132.810.591.500'], ['A08.186.211.132.810.428.600'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and Cellular Labeling of Caged Phosphatidylinositol Derivatives. | Phosphatidylinositol (PI) is the biosynthetic precursor for seven phosphoinositides, important signaling lipids in cells. A membrane-permeant caged PI derivative featuring a photo-removable coumarinyl group masking the negative charge of the phosphate, as well as two enzymatically removable butyrate esters for increase... | ['Cell Membrane', 'Click Chemistry', 'HeLa Cells', 'Humans', 'Microscopy, Fluorescence', 'Phosphatidylinositols', 'Staining and Labeling'] | 31,550,056 | [['A11.284.149'], ['E05.197.124', 'J01.897.836.249.124'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.458', 'E05.595.458'], ['D10.570.755.375.760.400.942'], ['E01.370.225.500.620.670', 'E01.370.225.750.600.670', 'E05.200.500.620.670',... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Potassium currents in the inner segment of single retinal cone photoreceptors. | 1. The K+ currents of cone inner segments isolated from the retina of a lizard were studied with the use of tight-seal electrodes in the whole cell configuration. To conduct these studies other identified currents in the cell were blocked. Co2+ blocked a voltage-dependent Ca2+ current and a Ca2(+)-dependent Cl- current... | ['Action Potentials', 'Animals', 'Cesium', 'Cobalt', 'In Vitro Techniques', 'Kinetics', 'Lizards', 'Photoreceptor Cells', 'Potassium Channels', 'Retina', 'Solutions', 'Synapses', 'Tetraethylammonium', 'Tetraethylammonium Compounds'] | 2,074,473 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D01.268.549.125', 'D01.268.556.165', 'D01.552.528.160', 'D01.552.544.165'], ['D01.268.556.185', 'D01.268.956.155', 'D01.552.544.185'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.833.393'], ['A08.675.650.850.625', 'A08.675.650.915... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of electronic healthcare records to identify complex patients with atrial fibrillation for targeted intervention. | Background: Practice guidelines recommend anticoagulation therapy for patients with atrial fibrillation (AF) who have other risk factors putting them at an elevated risk of stroke. These patients remain undertreated, but, with increasing use of electronic healthcare records (EHRs), it may be possible to identify candid... | ['Algorithms', 'Anticoagulants', 'Atrial Fibrillation', 'Electronic Health Records', 'Hemorrhage', 'Humans', 'Natural Language Processing', 'Risk Assessment', 'Risk Factors', 'Stroke'] | 27,375,290 | [['G17.035', 'L01.224.050'], ['D27.505.954.502.119'], ['C14.280.067.198', 'C23.550.073.198'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.050.375.580'], ['E05... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Triblock copolymer-based microchip device for rapid analysis of stuffer-free multiplex ligation-dependent probe amplification products. | Recent improvements in the multiplex ligation-dependent probe amplification (MLPA) method promise successful multiplex analysis of various genetic markers. In particular, it has been demonstrated that elimination of the stuffer sequence included in MLPA probes for length-dependent analysis substantially simplifies the ... | ['Animals', 'Bacteria', 'DNA Probes', 'DNA, Bacterial', 'Electrophoresis, Microchip', 'Equipment Design', 'Milk', 'Molecular Typing', 'Multiplex Polymerase Chain Reaction', 'Polyethylene Glycols', 'Polymorphism, Single-Stranded Conformational', 'Propylene Glycols', 'Reproducibility of Results'] | 23,135,832 | [['B01.050'], ['B03'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['D13.444.308.212'], ['E05.196.401.190.500', 'E05.588.465.340'], ['E05.320'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J02.200.700', 'J02.500.350.525'], ['E01.370.225.875.150.125.457', 'E05.200... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Expectant fathers: influence of perinatal education on stress, coping, and spousal relations. | The purpose of this quasi-experimental study was to compare the effects of father-focused discussion perinatal classes with traditional childbirth classes on expectant fathers' stress/psychological symptom status, coping strategies, social support, and spousal relations (both supportive behavior toward their partners a... | ['Adaptation, Psychological', 'Adult', 'Curriculum', 'Fathers', 'Humans', 'Male', 'Marriage', 'Multivariate Analysis', 'Prenatal Care', 'Social Support', 'Stress, Psychological', 'Surveys and Questionnaires', 'Teaching'] | 9,256,875 | [['F01.058'], ['M01.060.116'], ['I02.158'], ['F01.829.263.500.320.100', 'I01.880.853.150.500.340.210', 'M01.620.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.315.500.500', 'I01.240.361.500.500', 'I01.880.853.150.423.500.500', 'N01.224.361.500.500', 'N01.824.308.500.500'], ['E05.318.740.150.500',... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
G9a orchestrates PCL3 and KDM7A to promote histone H3K27 methylation. | Methylation of histone H3-lysine 9 (H3K9) and H3K27 by the methyltransferase G9a and polycomb repressive complex 2 (PRC2) inhibits transcription of target genes. A crosstalk between G9a and PRC2 via direct physical interaction has been shown recently. Here, we demonstrate an alternative mechanism by which G9a promotes ... | ['Cadherins', 'Cell Line, Tumor', 'DNA-Binding Proteins', 'Gene Expression Regulation, Neoplastic', 'Histocompatibility Antigens', 'Histone-Lysine N-Methyltransferase', 'Humans', 'Jumonji Domain-Containing Histone Demethylases', 'Methylation', 'Nuclear Proteins', 'Pancreatic Neoplasms', 'Transcription Factors', 'Transc... | 26,688,070 | [['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.776.260'], ['G05.308.370'], ['D23.050.301.500', 'D23.050.705.552'], ['D08.811.913.555.500.800.200.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.662.582.475.500', 'D08.811... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Establishment and evaluation of a Chinese rhesus model of tuberculosis]. | OBJECTIVE: To establish and evaluate the Chinese rhesus model of tuberculosis.METHODS: Twelve Chinese rhesus macaques, randomly divided into 3 groups, were inoculated with 2 different doses of Mycobacterium tuberculosis H(37) Rv strain via both bronchoscopic and intratracheal instillation into the lungs. Clinical obser... | ['Animals', 'Bacterial Load', 'Blood Sedimentation', 'Disease Models, Animal', 'Granuloma', 'Lung', 'Macaca mulatta', 'Mycobacterium tuberculosis', 'Tuberculin Test', 'Tuberculosis'] | 23,290,041 | [['B01.050'], ['E01.370.225.875.150.115', 'E01.370.225.875.220.115', 'E05.200.875.150.115', 'E05.200.875.220.115', 'G06.099.100'], ['E01.370.225.625.125', 'E05.200.625.125'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C15.604.515.292', 'C23.550.382'], ['A04.411'], ['B01.050.150.900.649.313.988.400.112.199.120.510... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of the dithiocarbamate fungicide propineb in primary neuronal cell cultures and skeletal muscle cells of the rat. | After repeated-dose toxicity studies with the fungicide propineb, reversible effects on muscle functions were found. Therefore, mechanistic investigations should contribute to clarification of its mode of action in relation to disulfiram and diethyldithiocarbamate neurotoxicity or direct effects on muscle cells. In pri... | ['Animals', 'Carbon Disulfide', 'Cell Survival', 'Cells, Cultured', 'Cerebral Cortex', 'Chlorides', 'Cytoskeleton', 'Disulfiram', 'Ditiocarb', 'Dose-Response Relationship, Drug', 'Enzyme-Linked Immunosorbent Assay', 'Fungicides, Industrial', 'Glucose', 'Muscle, Skeletal', 'Neurons', 'Rats', 'Thiourea', 'Zinc Compounds'... | 12,111,006 | [['B01.050'], ['D01.200.210', 'D01.875.350.850.074'], ['G04.346'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['D01.210.450.150', 'D01.248.497.158.215'], ['A11.284.430.214.190.750'], ['D02.241.081.251.869.220.250', 'D02.886.520.150.175', 'D02.886.706.200.200'], ['D02.241.081.251.869.220', 'D02.886.706.200'], ['G07.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pheochromocytoma and paraganglioma in cyanotic congenital heart disease. | CONTEXT: Aberrant cellular oxygen sensing is a leading theory for development of pheochromocytoma (PHEO) and paraganglioma (PGL).OBJECTIVE: The objective of the study was to test the hypothesis that chronic hypoxia in patients with cyanotic congenital heart disease (CCHD) increases the risk for PHEO-PGL.DESIGN/SETTING/... | ['Adolescent', 'Adrenal Gland Neoplasms', 'Adult', 'Cross-Sectional Studies', 'Cyanosis', 'Female', 'Heart Defects, Congenital', 'Humans', 'Male', 'Middle Aged', 'Paraganglioma', 'Pheochromocytoma', 'Retrospective Studies', 'Young Adult'] | 25,581,599 | [['M01.060.057'], ['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C23.888.248'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.465.625... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ventricular fibrillation in a conscious canine model--its prevention by UM-272. | The antifibrillatory properties of UM-272 (dimethylpropranolol; Pranolium) were evaluated in a conscious canine model of sudden coronary death. The initial preparation of the animal model was carried out under surgical anesthesia and involved the intraluminal implantation of a Teflon-coated silver wire into the circumf... | ['Animals', 'Anti-Arrhythmia Agents', 'Disease Models, Animal', 'Dogs', 'Electrocardiography', 'Male', 'Myocardial Infarction', 'Propranolol', 'Ventricular Fibrillation'] | 6,852,097 | [['B01.050'], ['D27.505.954.411.097'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.370.380.240', 'E01.370.405.240'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['D02.033.100.624.698.711', 'D02.033.755.624.698.711', 'D02... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glomerular hypertension and injury in desoxycorticosterone-salt rats on antihypertensive therapy. | Uninephrectomized male Munich-Wistar rats received either weekly subcutaneous injections of vehicle and water for drinking; injections of desoxycorticosterone (DOC) and 1% saline (SALT) for drinking; or DOC and SALT with hydrochlorthiazide, hydralazine, reserpine and KCl added. All studies were performed six weeks afte... | ['Animals', 'Blood Pressure', 'Capillaries', 'Desoxycorticosterone', 'Hydralazine', 'Hydrochlorothiazide', 'Hypertension, Renal', 'Kidney Glomerulus', 'Male', 'Rats', 'Rats, Inbred Strains', 'Reserpine', 'Sodium Chloride'] | 3,573,536 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A07.015.461.165'], ['D04.210.500.745.745.654.339', 'D06.472.040.585.611'], ['D03.383.710.605.500'], ['D02.886.590.700.135.261.476', 'D02.886.655.500.261.476', 'D03.633.100.174.261.476'], ['C12.777.419.331', 'C13.351.968.419.331', 'C14.907.489.631'], ['A05.810.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Computer-aided semen analysis: sperm concentration assessment by the Str?mberg-Mika system. | The scope of this study was to evaluate the accuracy, precision and specificity of the sperm concentration measurements by the Str?mberg-Mika Cell Motion Analyser (SM-CMA). Our data show that the instrument generally underscores the sperm concentration and therefore the uncorrected measurements must be corrected by the... | ['Autoanalysis', 'Computers', 'Humans', 'Male', 'Reproducibility of Results', 'Semen', 'Sensitivity and Specificity', 'Sperm Count'] | 7,755,190 | [['E05.059'], ['L01.224.230.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['A12.200.732'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Mini Asymmetric Radial Keratotomy and Corneal Cross-linking for the Treatment of a Bilateral Stage IV Keratoconus in a 14-year-old Child. | AIM: To present the case of a 14-year-old boy with bilateral stage IV keratoconus, treated with a combined MARK + CXL intervention, without the need for a corneal transplantation.RESULTS: The left eye displays considerable improvements, with a follow-up of 13.5 years: Kmax is decreased by 5.53 D, Kmed is decreased by 1... | ['Adolescent', 'Anti-Inflammatory Agents, Non-Steroidal', 'Cornea', 'Cross-Linking Reagents', 'Follow-Up Studies', 'Humans', 'Keratoconus', 'Keratotomy, Radial', 'Male', 'Ophthalmic Solutions', 'Photosensitizing Agents', 'Riboflavin', 'Time Factors', 'Treatment Outcome', 'Visual Acuity'] | 28,428,679 | [['M01.060.057'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['A09.371.060.217'], ['D27.720.470.410.210'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.204.627'], ['E04.540.825.55... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Quantitative detection of respiratory Chlamydia pneumoniae infection by real-time PCR. | Real-time PCR was evaluated as a quantitative diagnostic method for Chlamydia pneumoniae infection using different respiratory samples. Real-time PCR had efficiency equal to or better than that of nested touchdown PCR. This study confirmed sputum as the best sampling material to detect an ongoing C. pneumoniae infectio... | ['Chlamydophila Infections', 'Chlamydophila pneumoniae', 'Culture Media', 'DNA, Bacterial', 'Humans', 'Nasopharynx', 'Pharynx', 'Pneumonia, Bacterial', 'Polymerase Chain Reaction', 'Respiratory Tract Infections', 'Sputum'] | 12,037,108 | [['C01.150.252.400.210.250'], ['B03.440.190.190.230.249'], ['D27.720.470.305', 'E07.206'], ['D13.444.308.212'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.623.557', 'A14.724.557'], ['A03.556.750', 'A04.623', 'A14.724'], ['C01.150.252.620', 'C01.748.610.540', 'C08.381.677.540', 'C08.730.610.540'], ['E05.393.... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Participation of macrophages in chloramphenicol-potentiated carrageenin-induced peritonitis in rats. | 1. We investigated the possible potentiating effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the response of polymorphonuclear neutrophils to carrageenin (150 micrograms, ip) or dextran (100 micrograms, ip) in the peritoneal cavity of male Wistar rats (180-230 g; N = 12 in each group). 2. C... | ['Animals', 'Carrageenan', 'Chloramphenicol', 'Drug Synergism', 'Leukocyte Count', 'Macrophages', 'Male', 'Neutrophils', 'Peritonitis', 'Rats', 'Rats, Wistar'] | 8,257,939 | [['B01.050'], ['D09.698.152'], ['D02.033.455.706.300', 'D02.455.426.559.389.565.175', 'D02.640.529.175'], ['G07.690.773.968.477'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.107.595', 'E05.242.195.107.595', 'G04.140.107.595', 'G09.188.105.595'], ['A11.329.372', 'A... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antibiotic use and resistance in emerging economies: a situation analysis for Viet Nam. | BACKGROUND: Antimicrobial resistance is a major contemporary public health threat. Strategies to contain antimicrobial resistance have been comprehensively set forth, however in developing countries where the need for effective antimicrobials is greatest implementation has proved problematic. A better understanding of ... | ['Anti-Bacterial Agents', 'Bacterial Infections', 'Developing Countries', 'Drug Resistance, Bacterial', 'Drug Utilization', 'Health Policy', 'Humans', 'Vietnam'] | 24,325,208 | [['D27.505.954.122.085'], ['C01.150.252'], ['I01.615.500.300'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['N04.452.706.477'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.145.945']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Predicting species diversity of benthic communities within turbid nearshore using full-waveform bathymetric LiDAR and machine learners. | Epi-macrobenthic species richness, abundance and composition are linked with type, assemblage and structural complexity of seabed habitat within coastal ecosystems. However, the evaluation of these habitats is highly hindered by limitations related to both waterborne surveys (slow acquisition, shallow water and low rea... | ['Animals', 'Biodiversity', 'Canada', 'Geography', 'Invertebrates', 'Marine Biology'] | 21,701,576 | [['B01.050'], ['G16.500.275.157.049', 'N06.230.124.049'], ['Z01.107.567.176'], ['H01.277.500'], ['B01.050.500'], ['H01.158.273.248.750.500', 'H01.277.249.750.500', 'H01.277.750.500']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
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