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Severity of hypertension predicts the generalized neurocognitive deficit in schizophrenia. | Individuals with schizophrenia have been found to display neurocognitive deficits on the order of 1 standard deviation below the mean of healthy controls on a range of cognitive domains, with no clear pattern of deficits that characterizes the majority of individuals with schizophrenia. Such findings have led some to s... | ['Cognition', 'Cognition Disorders', 'Humans', 'Hypertension', 'Neuropsychological Tests', 'Prognosis', 'Psychiatric Status Rating Scales', 'Schizophrenia', 'Schizophrenic Psychology', 'Severity of Illness Index'] | 27,397,721 | [['F02.463.188'], ['F03.615.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['F04.711.513'], ['E01.789'], ['F04.711.513.653'], ['F03.700.750'], ['F04.824'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Development of health risk appraisal functions in the presence of multiple indicators: the Framingham Study nursing home institutionalization model. | A health risk appraisal function is a mathematical model designed to estimate the risk or probability of a person's mortality or morbidity for various diseases based upon risk factors such as age, medical history and smoking behaviour. The Framingham Study has contributed substantially to the development and use of the... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Follow-Up Studies', 'Geriatric Assessment', 'Humans', 'Institutionalization', 'Male', 'Middle Aged', 'Models, Theoretical', 'Morbidity', 'Mortality', 'Nursing Homes', 'Probability', 'Risk'] | 7,481,208 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['B01.050.150.900.649.313.988.400... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
ã-Tocotrienol attenuates TNF-á-induced changes in secretion and gene expression of MCP-1, IL-6 and adiponectin in 3T3-L1 adipocytes. | Tocotrienols, members of the vitamin E family, have been shown to possess anti-inflammatory properties and display activity against a variety of chronic diseases, such as cancer, cardiovascular and neurological diseases. However, whether tocotrienols contribute to the prevention of inflammatory responses in adipose tis... | ['3T3-L1 Cells', 'Adipocytes', 'Adiponectin', 'Animals', 'Chemokine CCL2', 'Chromans', 'Gene Expression Regulation', 'I-kappa B Kinase', 'Interleukin-6', 'Mice', 'NF-kappa B', 'PPAR gamma', 'Phosphorylation', 'Tumor Necrosis Factor-alpha', 'Vitamin E', 'Vitamins'] | 22,293,775 | [['A11.251.210.100.775.800', 'A11.329.228.100.775.800'], ['A11.329.114'], ['D06.472.699.042.249', 'D12.644.276.024.249', 'D12.644.548.011.249', 'D12.776.467.024.249', 'D23.529.024.249'], ['B01.050'], ['D12.644.276.374.200.110.990.600', 'D12.776.467.374.200.110.990.600', 'D23.125.300.110.990.600', 'D23.469.200.110.990.6... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Natriuretic peptide system: a link between fat mass and cardiac hypertrophy and hypertension in fat-fed female rats. | The present study was designed to develop an animal model of hypertension and cardiac hypertrophy associated with obesity in female rats. Furthermore, we studied the involvement of the natriuretic peptide system in the mechanisms of these conditions. Obesity was induced in Wistar rats by a high fat diet and ovariectomy... | ['Animals', 'Atrial Natriuretic Factor', 'Blood Pressure', 'Cardiomegaly', 'Diet', 'Dietary Fats', 'Disease Models, Animal', 'Female', 'Gene Expression', 'Heart', 'Hypertension', 'Intra-Abdominal Fat', 'Obesity', 'Organ Size', 'Ovariectomy', 'Ovary', 'RNA, Messenger', 'Rats', 'Rats, Wistar', 'Receptors, Atrial Natriure... | 21,237,215 | [['B01.050'], ['D06.472.699.584.500', 'D12.644.548.585.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C14.280.195', 'C23.300.775.250'], ['G07.203.650.240'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.297'], ['A07.541'], ['C14.907.489'], ['A10.165.114.83... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Age differences in affective decision making as indexed by performance on the Iowa Gambling Task. | Contemporary perspectives on age differences in risk taking, informed by advances in developmental neuroscience, have emphasized the need to examine the ways in which emotional and cognitive factors interact to influence decision making. In the present study, a diverse sample of 901 individuals between the ages of 10 a... | ['Adolescent', 'Adult', 'Affect', 'Age Factors', 'Aging', 'Child', 'Decision Making', 'Female', 'Gambling', 'Humans', 'Intelligence', 'Male', 'Neuropsychological Tests', 'Surveys and Questionnaires', 'Young Adult'] | 20,053,017 | [['M01.060.057'], ['M01.060.116'], ['F01.470.047'], ['N05.715.350.075', 'N06.850.490.250'], ['G07.345.124'], ['M01.060.406'], ['F02.463.785.373'], ['F01.145.722.408', 'F03.250.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.543'], ['F04.711.513'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.52... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal carcinoma. | The long non-coding RNA (lncRNA) H19 has been recently shown to participate in the progression of cancer, including metastasis. However, the biological role of H19 and the underlying mechanisms mediating its functions in nasopharyngeal carcinoma (NPC) remain unclear. Herein, we found that H19 was overexpressed in NPC t... | ['Carcinoma', 'Cell Line, Tumor', 'Enhancer of Zeste Homolog 2 Protein', 'Gene Expression Regulation, Neoplastic', 'Humans', 'MicroRNAs', 'Nasopharyngeal Carcinoma', 'Nasopharyngeal Neoplasms', 'Neoplasm Invasiveness', 'RNA, Long Noncoding'] | 27,040,767 | [['C04.557.470.200'], ['A11.251.210.190', 'A11.251.860.180'], ['D05.500.781.750.250', 'D08.811.913.555.500.800.200.500.500.500', 'D12.776.660.235.600.200.250', 'D12.776.664.235.800.200.250', 'D12.776.930.780.890.200.250'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.73... | ['Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A rapid method for detecting protein-nucleic acid interactions by protein induced fluorescence enhancement. | Many fundamental biological processes depend on intricate networks of interactions between proteins and nucleic acids and a quantitative description of these interactions is important for understanding cellular mechanisms governing DNA replication, transcription, or translation. Here we present a versatile method for r... | ['Anisotropy', 'DNA', 'DNA Repair', 'DNA Replication', 'Deoxyribonuclease BamHI', 'Fluorescence', 'Fluorescent Dyes', 'Humans', 'Ions', 'Ku Autoantigen', 'Microscopy, Fluorescence', 'Nucleic Acids', 'Protein Binding', 'Protein Biosynthesis', 'Proteins', 'RNA', 'Spectrometry, Fluorescence', 'Transcription, Genetic'] | 28,008,962 | [['G01.590.040', 'G02.050'], ['D13.444.308'], ['G02.111.222', 'G05.219'], ['G02.111.225', 'G05.226'], ['D08.811.150.280.260.240', 'D08.811.277.352.335.350.300.260.240', 'D08.811.277.352.355.325.300.260.240'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.0... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Surface plasmon resonance biosensor based on Au nanoparticle in titania sol-gel membrane. | A novel surface plasmon resonance (SPR) biosensor for the determination of human IgG was introduced. The biosensor was prepared with three layers of titania sol-gel membrane by vapor deposition. The colloid Au nanoparticle (AuNP) was immobilized in the second layer of titania membrane and the AuNP coupled with rabbit a... | ['Biosensing Techniques', 'Gels', 'Gold', 'Humans', 'Immunoglobulin G', 'Membranes, Artificial', 'Metal Nanoparticles', 'Surface Plasmon Resonance', 'Surface Properties', 'Time Factors', 'Titanium'] | 19,846,285 | [['E05.601.043'], ['D20.280.320', 'D26.255.165.320'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A-Raf associates with and regulates platelet-derived growth factor receptor signalling. | Raf kinases are important intermediates in epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) mediated activation of the mitogen-activated protein kinase (MAPK) pathway. In this report, we show that the A-Raf kinase is associated with activated EGF receptor complexes and with PDGF receptor (PDGFR) ... | ['Animals', 'COS Cells', 'Chlorocebus aethiops', 'ErbB Receptors', 'Humans', 'Mice', 'Mutation', 'NIH 3T3 Cells', 'Organ Specificity', 'Phosphatidylinositol 3-Kinases', 'Phospholipase C gamma', 'Phosphorylation', 'Proto-Oncogene Proteins A-raf', 'Proto-Oncogene Proteins c-raf', 'Receptors, Platelet-Derived Growth Facto... | 15,763,428 | [['B01.050'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['G05.365.59... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Suppression of the avian sarcoma virus genome in 8-azaquanine-resistant, transformed, hamster cells. | The avian sarcoma virus genome (Schmidt-Ruppin strain) in transformed hamster cells resistant to 8-azaquanine [Ha(SR)AG-50] was strongly suppressed. The suppression was genetically stable and could not be overcome by attempts at induction with 5-iodo-2'-deoxyuridine. Fusion of hamster cells, which had suppressed virus ... | ['Animals', 'Avian Sarcoma Viruses', 'Azaguanine', 'Cell Fusion', 'Cells, Cultured', 'Cricetinae', 'Drug Resistance', 'Genes', 'Helper Viruses', 'Idoxuridine', 'Phenotype', 'Recombination, Genetic', 'Transformation, Genetic', 'Viral Proteins', 'Virus Replication'] | 187,768 | [['B01.050'], ['B04.613.807.070.120', 'B04.820.650.070.120'], ['D02.145.250', 'D03.633.100.759.758.399.454.300'], ['E05.242.307', 'G04.155'], ['A11.251'], ['B01.050.150.900.649.313.992.635.075.250'], ['G07.690.773.984'], ['G05.360.340.024.340'], ['B04.423'], ['D03.383.742.680.852.300.400', 'D13.570.230.430.609', 'D13.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The impact of recipient factors on the lower-than-expected hemoglobin increment in transfused outpatients with hematologic diseases. | BACKGROUND: Patients with cancer or chronic hematologic disorders frequently receive red blood cell (RBC) transfusions. Based on long-standing assumptions, each RBC unit is thought to increase recipient hemoglobin by 1 g/dL, but smaller increments can occur. A better understanding of recipient factors affecting hemoglo... | ['Aged', 'Cross-Sectional Studies', 'Erythrocyte Transfusion', 'Female', 'Hematologic Neoplasms', 'Hemoglobins', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies'] | 31,270,827 | [['M01.060.116.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E02.095.135.140.275'], ['C04.588.448', 'C15.378.400'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Improved post-ischemic ventricular recovery in the absence of changes in energy metabolism in working rat hearts following heat-shock. | We have previously demonstrated that induction of the heat-shock response in rats results in improved recovery of isolated Langendorff-perfused rat hearts subjected to low-flow ischemia followed by reperfusion (Currie et al., 1988). The mechanisms underlying this protective effect of heat-shock are uncertain although t... | ['Adenosine Diphosphate', 'Adenosine Monophosphate', 'Adenosine Triphosphate', 'Animals', 'Coronary Disease', 'Energy Metabolism', 'Heart Ventricles', 'Hot Temperature', 'Lactates', 'Male', 'Phosphocreatine', 'Physical Exertion', 'Rats', 'Rats, Inbred Strains', 'Ventricular Function'] | 2,231,733 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D03.633.100.759.646.138.180', 'D13.695.667.138.180', 'D13.695.827.068.180'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['C14.280.647.250', 'C14.907.585.250'], ['G03.295'], ['A07.541.560'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Chromosomal translocation involving the beta T cell receptor gene in acute leukemia. | DNA spanning a t(7;19) chromosomal translocation breakpoint was isolated from the human T cell line SUP-T7 established from an acute lymphoblastic leukemia. Nucleotide sequence analysis showed that the point of crossover on chromosome 7 occurred immediately adjacent to joining segment J beta 1.1 within the TCR-beta gen... | ['Base Sequence', 'Chromosomes, Human, Pair 19', 'Chromosomes, Human, Pair 7', 'Cloning, Molecular', 'Humans', 'Leukemia, Lymphoid', 'Molecular Sequence Data', 'Receptors, Antigen, T-Cell', 'Transcription, Genetic', 'Translocation, Genetic'] | 3,162,254 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.284.187.520.300.460.465', 'G05.360.162.520.300.460.465'], ['A11.284.187.520.300.325.335', 'G05.360.162.520.300.325.335'], ['E05.393.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.428', 'C15.604.515.560', 'C20.683.515.528'], ['L01.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan. | Malaria, caused by parasites of the genus Plasmodium, leads to over half a million deaths per year, 90% of which are caused by Plasmodium falciparum. P. vivax usually causes milder forms of malaria; however, P. vivax can remain dormant in the livers of infected patients for weeks or years before re-emerging in a new bo... | ['Antimalarials', 'Binding Sites', 'Enzyme Activation', 'Folic Acid Antagonists', 'Models, Molecular', 'Molecular Conformation', 'Plasmodium', 'Protein Binding', 'Structure-Activity Relationship', 'Tetrahydrofolate Dehydrogenase', 'Triclosan'] | 29,348,637 | [['D27.505.954.122.250.100.085'], ['G02.111.570.120'], ['G02.111.263', 'G03.328'], ['D27.505.519.389.350'], ['E05.599.595'], ['G02.111.570.820'], ['B01.043.075.380.611'], ['G02.111.679', 'G03.808'], ['G02.111.830', 'G07.690.773.997'], ['D08.811.682.662.825'], ['D02.355.726.900', 'D02.455.426.559.389.657.654.900']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Corneal stromal demarcation line determined with anterior segment optical coherence tomography following a very high intensity corneal collagen cross-linking protocol. | PURPOSE: To evaluate corneal stromal demarcation line depth after very high intensity (18 mW/cm) ultraviolet-A irradiation for a 5-minute corneal collagen cross-linking (CXL) protocol with the use of anterior segment optical coherence tomography.METHODS: This prospective interventional study enrolled 14 patients (18 ey... | ['Adult', 'Cell Count', 'Collagen', 'Corneal Endothelial Cell Loss', 'Corneal Stroma', 'Corneal Topography', 'Cross-Linking Reagents', 'Endothelium, Corneal', 'Female', 'Follow-Up Studies', 'Humans', 'Keratoconus', 'Male', 'Photochemotherapy', 'Photosensitizing Agents', 'Prospective Studies', 'Riboflavin', 'Tomography,... | 25,811,721 | [['M01.060.116'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['D05.750.078.280', 'D12.776.860.300.250'], ['C11.204.278', 'C11.300.250', 'C23.550.767.093', 'C23.888.307.250'], ['A09.371.060.217.228'], ['E01.370.380.150'], ['D27.720.470.410.210'], ['A09.371.060.067.318', 'A09.371.060.217.318', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Two closely related genes of Arabidopsis encode plastidial cytidinediphosphate diacylglycerol synthases essential for photoautotrophic growth. | Cytidinediphosphate diacylglycerol synthase (CDS) catalyzes the formation of cytidinediphosphate diacylglycerol, an essential precursor of anionic phosphoglycerolipids like phosphatidylglycerol or -inositol. In plant cells, CDS isozymes are located in plastids, mitochondria, and microsomes. Here, we show that these iso... | ['Alleles', 'Arabidopsis', 'Autotrophic Processes', 'DNA, Bacterial', 'Diacylglycerol Cholinephosphotransferase', 'Genes, Plant', 'Genetic Complementation Test', 'Glycerophospholipids', 'Isoenzymes', 'Light', 'Membrane Lipids', 'Mutagenesis, Insertional', 'Mutation', 'Phenotype', 'Plastids', 'Protein Transport', 'Sacch... | 20,442,275 | [['G05.360.340.024.340.030'], ['B01.650.940.800.575.912.250.157.100'], ['G02.111.071', 'G03.087'], ['D13.444.308.212'], ['D08.811.913.696.900.200'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['E05.393.281.526'], ['D10.570.755.375.760.400'], ['D08.811.348', 'D12.776.800.300'], ['G01.358.500.505.650', 'G01.590.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Disruption of vascular Ca2+-activated chloride currents lowers blood pressure. | High blood pressure is the leading risk factor for death worldwide. One of the hallmarks is a rise of peripheral vascular resistance, which largely depends on arteriole tone. Ca2+-activated chloride currents (CaCCs) in vascular smooth muscle cells (VSMCs) are candidates for increasing vascular contractility. We analyze... | ['15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid', 'Animals', 'Anoctamin-1', 'Arterioles', 'Blood Pressure', 'Brain', 'Chloride Channels', 'Cloning, Molecular', 'DNA, Complementary', 'Electrophysiology', 'Estrogen Antagonists', 'HEK293 Cells', 'Humans', 'Hypertension', 'Membrane Potentials', 'Mesent... | 24,401,273 | [['D01.248.497.158.685.750.744.650.500.500', 'D01.339.431.374.744.650.500.500', 'D01.650.550.750.700.650.500.500', 'D02.389.338.638.650.500.500', 'D10.251.355.255.550.025.650.500.500', 'D23.469.050.175.725.025.650.500.500', 'D23.469.700.630.500'], ['B01.050'], ['D12.776.157.530.400.175.032.500', 'D12.776.543.550.450.17... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Community and state systems change associated with the healthy transitions initiative. | People engaged in efforts to improve services to emerging adults with serious mental health challenges have reached the conclusion that service change at the program or agency level is not sustainable without related changes at the systems or policy level. This article focuses on one set of efforts to create intentiona... | ['Adult', 'Community Mental Health Services', 'Delivery of Health Care', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Mental Health', 'Organizational Innovation', 'Organizational Objectives', 'Program Evaluation', 'Residence Characteristics', 'State Government', 'Systems Theory'] | 25,537,434 | [['M01.060.116'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['N04.590.374', 'N05.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F02.418', 'N01.400.500'], ['N04.452.610'], ['N04.452.615'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['N01.224.791', 'N06.850.505.400.800'], ['I01.40... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Family-Centered Communication and Acute Stress in Israeli Intensive Care Units. | BACKGROUND: Intensive care unit stays can be stressful for patients' family members. Family-centered communication has 6 components: fostering relationships, exchanging information, responding to emotions, managing uncertainty, making decisions, and enabling patient self-management. Whether these communication componen... | ['Adult', 'Communication', 'Critical Care', 'Cross-Sectional Studies', 'Emotions', 'Family', 'Female', 'Humans', 'Intensive Care Units', 'Israel', 'Length of Stay', 'Male', 'Middle Aged', 'Nursing Staff, Hospital', 'Patient Participation', 'Professional-Family Relations', 'Stress, Psychological', 'Tertiary Care Centers... | 31,263,010 | [['M01.060.116'], ['F01.145.209', 'L01.143'], ['E02.760.190', 'N02.421.585.190'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.470'], ['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['Z01.252.245.500.375'], ['E02.760.400.4... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis. | BACKGROUND: The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)-1â and IL-18 cytokine processing complex that is activated in inflammatory conditions. The role of the NLRP3 inflammasome in the pathogenesis of atherosclerosis and myocardial infarction is not fully understood.METHODS AND... | ['Atherosclerosis', 'CARD Signaling Adaptor Proteins', 'Caspase 1', 'Chemokine CCL2', 'Genotype', 'Humans', 'Immunohistochemistry', 'Inflammasomes', 'Interleukin-18', 'Interleukin-1beta', 'Leukocytes, Mononuclear', 'Myocardial Infarction', 'NLR Family, Pyrin Domain-Containing 3 Protein', 'Plaque, Atherosclerotic', 'Pol... | 27,207,962 | [['C14.907.137.126.307'], ['D12.644.360.024.131', 'D12.644.360.075.358', 'D12.776.157.057.006', 'D12.776.476.024.139', 'D12.776.476.075.358'], ['D08.811.277.656.262.500.126.550.100', 'D08.811.277.656.300.200.126.550.100', 'D12.644.360.075.405.550.100', 'D12.776.476.075.405.550.100'], ['D12.644.276.374.200.110.990.600',... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse. | Rod-specific cGMP phosphodiesterase (PDE) is a key enzyme of the phototransduction cascade, and mutations in its catalytic subunits have been associated with retinal degenerative diseases. The bovine delta-subunit solubilises the normally membrane-bound PDE and is the only subunit expressed in extraocular tissues. We i... | ["3',5'-Cyclic-GMP Phosphodiesterases", 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cattle', 'Chromosome Mapping', 'Cloning, Molecular', 'DNA Primers', 'DNA, Complementary', 'Exons', 'Humans', 'Introns', 'Mice', 'Molecular Sequence Data', 'Mutation', 'Polymorphism, Single-Stranded Conformational', 'RNA, Messeng... | 9,781,033 | [['D08.811.277.352.640.155', 'D12.644.360.009', 'D12.776.476.009'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.150.900.649.313.500.380.271'], ['E05.393.183'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Treatment of malaria in north-eastern and south-eastern Nigeria: a population study of mefloquine, sulphadoxine, pyrimethamine combination (MSP) vs chloroquine (CQ). | In a population-based study involving 4019 patients in 20 peripheral health facilities in Nigeria, the outcome of presumptive malaria treatment with MSP was compared to that of CQ. The study was conducted between January 1995 and January 1996. Patients aged 6 months or more with a clinical diagnosis of malaria based on... | ['Adult', 'Antimalarials', 'Chloroquine', 'Drug Combinations', 'Drug Resistance', 'Female', 'Fever', 'Humans', 'Malaria, Falciparum', 'Male', 'Mefloquine', 'Middle Aged', 'Nigeria', 'Prospective Studies', 'Pyrimethamine', 'Sulfadoxine', 'Treatment Outcome'] | 11,391,844 | [['M01.060.116'], ['D27.505.954.122.250.100.085'], ['D03.633.100.810.050.180'], ['D26.310'], ['G07.690.773.984'], ['C23.888.119.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.530.650', 'C01.920.875.650'], ['D03.633.100.810.410'], ['M01.060.116.630'], ['Z01.058.290.190.565'], ['E05.318.372.500.750... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Positive IgG Western blot for Borrelia burgdorferi in Colombia. | In order to evaluate the presence of specific IgG antibodies to Borrelia burgdorferi in patients with clinical manifestations associated with Lyme borreliosis in Cali, Colombia, 20 serum samples from patients with dermatologic signs, one cerebrospinal fluid (CSF) sample from a patient with chronic neurologic and arthri... | ['Antibodies, Bacterial', 'Blotting, Western', 'Borrelia burgdorferi Group', 'Colombia', 'Humans', 'Immunoglobulin G', 'Lyme Disease', 'Scleroderma, Localized'] | 10,446,009 | [['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B03.440.425.410.711.193.150', 'B03.851.595.193.150'], ['Z01.107.757.284'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Tumor heterogeneity and personalized cancer medicine: are we being outnumbered? | Tumor heterogeneity is regarded as a major obstacle to successful personalized cancer medicine. The lack of reliable response assays reflective of in vivo tumor heterogeneity and associated resistance mechanisms hampers identification of reliable biomarkers. By contrast, oncogene addiction and paracrine signaling enabl... | ['Animals', 'Antineoplastic Agents', 'Biomarkers, Tumor', 'Drug Resistance, Neoplasm', 'Humans', 'Neoplasms', 'Phenotype', 'Precision Medicine'] | 24,559,448 | [['B01.050'], ['D27.505.954.248'], ['D23.101.140'], ['G07.690.773.984.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['G05.695'], ['E02.782', 'H02.403.200.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of the Cobas Ampliprep/Cobas TaqMan HBV Test versus the Cobas Amplicor HBV monitor for HBV-DNA detection and quantification during antiviral therapy. | Performances of the new automatic system COBAS AmpliPrep/COBAS TaqMan 48 (CAP/CTM) (Roche, Branchburg, NJ) for HBV DNA extraction and real-time PCR quantification were assessed and compared with the endpoint PCR COBAS AMPLICOR HBV Monitor (CAHBM, Roche). Analytical evaluation with proficiency panels from UK National Ex... | ['Adenine', 'Antiviral Agents', 'Automation', 'DNA, Viral', 'Hepatitis B Surface Antigens', 'Hepatitis B virus', 'Hepatitis B, Chronic', 'Humans', 'Lamivudine', 'Organophosphonates', 'Polymerase Chain Reaction', 'Taq Polymerase'] | 18,437,839 | [['D03.633.100.759.138'], ['D27.505.954.122.388'], ['J01.897.104'], ['D13.444.308.568'], ['D23.050.327.495.500.475'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440.435.100', 'C06.552.380.350.100', 'C06.552.380.705.437.100'], ['B01.050.150.900.649.313.988... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effect of high pressure homogenisation of milk on cheese yield and microbiology, lipolysis and proteolysis during ripening of Caciotta cheese. | The principal aim of this work was to compare Caciotta cheeses obtained from cow milk previously subjected to high pressure homogenisation (HPH) at 100 MPa with those produced from raw (R) or heat-treated (P) cow milk. HPH had both direct and indirect effects on cheese characteristics and their evolution during ripenin... | ['Animals', 'Cattle', 'Cheese', 'Colony Count, Microbial', 'Fats', 'Female', 'Fermentation', 'Food Handling', 'Food Microbiology', 'Food Technology', 'Hydrostatic Pressure', 'Lipolysis', 'Milk', 'Milk Proteins', 'Taste', 'Time Factors'] | 16,476,182 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G07.203.200.500.444', 'G07.203.300.350.300.444', 'J02.350.500.444', 'J02.500.350.300.444'], ['E01.370.225.875.220', 'E05.200.875.220'], ['D10.212'], ['G02.111.158.249', 'G03.191.249'], ['J01.576.423.200'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Nucleotide sequence of the large terminal repeat of two different strains of gibbon ape leukemia virus. | Gibbon ape leukemia virus, SEATO strain (GaLV-SEATO), a virus that induces myeloid leukemia in gibbon apes, and GaLV, San Francisco strain (GaLV-SF), a virus associated etiologically with lymphocytic leukemia in gibbon apes, have been molecularly cloned. The complete nucleotide sequence of the large terminal repeats (L... | ['Animals', 'Base Sequence', 'Cloning, Molecular', 'DNA, Viral', 'Genes, Viral', 'Hylobates', 'Leukemia, Lymphoid', 'Repetitive Sequences, Nucleic Acid', 'Retroviridae', 'Species Specificity'] | 6,474,832 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.308.568'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['B01.050.150.900.649.313.988.400.112.420.390'], ['C04.557.337.428', 'C15.604.515.560', 'C20.683.515.528'], ['G02.111.570.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Flow cytometric method for quantifying viable Mycoplasma agassizii, an agent of upper respiratory tract disease in the desert tortoise (Gopherus agassizii). | AIMS: Mycoplasma agassizii can cause upper respiratory tract disease in the threatened desert tortoise of the Southwestern United States. Two technical challenges have impeded critical microbiological studies of this microorganism: (i) its small size limits the use of light microscopy for cell counting and (ii) its ext... | ['Animals', 'Flow Cytometry', 'Fluoresceins', 'Mycoplasma', 'Mycoplasma Infections', 'Respiratory Tract Diseases', 'Southwestern United States', 'Turtles'] | 20,132,436 | [['B01.050'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['B03.440.860.580.553.553'], ['C01.150.252.400.610.610'], ['C08'], ['Z01... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Comparison of first trimester, second trimester and integrated Down's syndrome screening results in unaffected pregnancies. | Our aim was to compare the results of first trimester combined test, second trimester triple test, and integrated test in the same pregnant population. We retrospectively studied 927 women, all giving birth to an unaffected baby except for two cases of Down's syndrome. The women underwent a nuchal translucency ultrasou... | ['Biomarkers', 'Chorionic Gonadotropin', 'Down Syndrome', 'Estriol', 'Female', 'Humans', 'Pregnancy', 'Pregnancy Trimester, First', 'Pregnancy Trimester, Second', 'Prenatal Diagnosis', 'Reproducibility of Results', 'alpha-Fetoproteins'] | 12,211,655 | [['D23.101'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['D04.210.500.365.415.331', 'D06.472.334.851.437.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['G08.68... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A pilot program for limited english proficiency high school immigrant students. | Limited English proficiency immigrant students have a high risk of dropping out of high school, resulting in significantly restricted employment opportunities. At the same time, the nursing profession is desperately in need of increased ethnic diversity in the workforce to better serve its diverse patient population. R... | ['Adolescent', 'Adult', 'Attitude', 'Career Choice', 'Cultural Diversity', 'Education, Nursing, Baccalaureate', 'Emigrants and Immigrants', 'Georgia', 'Health Services Needs and Demand', 'Humans', 'Multilingualism', 'Nursing Education Research', 'Pilot Projects', 'Program Development', 'Program Evaluation', 'Remedial T... | 17,828,019 | [['M01.060.057'], ['M01.060.116'], ['F01.100'], ['F02.463.785.373.346.400'], ['I01.076.201.450.350', 'I01.880.853.100.450'], ['I02.358.462.316'], ['M01.189'], ['Z01.107.567.875.075.250', 'Z01.107.567.875.750.370'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.559.423.452'],... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Systematic investigations of peak distortions due to additives in supercritical fluid chromatography. | The impact of eluent components added to improve separation performance in supercritical fluid chromatography was systematically, and fundamentally, investigated. The model system comprised basic pharmaceuticals as solutes and eluents containing an amine (i.e., triethylamine, diethylamine, or isopropylamine) as additiv... | ['Adsorption', 'Chromatography, Supercritical Fluid', 'Computer Simulation', 'Diethylamines', 'Ethylamines', 'Propylamines', 'Solvents'] | 32,204,879 | [['G01.030', 'G02.020'], ['E05.196.181.750'], ['L01.224.160'], ['D02.092.471.302'], ['D02.092.471'], ['D02.092.831'], ['D27.720.844']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Neurological symptoms and signs in Beh?et disease: a Western Turkey experience. | AIM: To assess the clinical patterns of neurologic involvement and the frequencies and characteristics of different types of headaches in patients with Beh?et disease.METHODS: Total 530 patients with Beh?et disease were evaluated for the presence of neurologic involvement and/or headache.RESULTS: Of the 54 patients (10... | ['Adult', 'Age of Onset', 'Behcet Syndrome', 'Female', 'Headache', 'Humans', 'Male', 'Retrospective Studies', 'Turkey', 'Young Adult'] | 21,532,383 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['C07.465.075', 'C11.941.879.780.880.200', 'C14.907.940.100', 'C16.320.382.250', 'C17.800.827.368.250', 'C17.800.862.150'], ['C23.888.592.612.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', '... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Circulating collagen metabolites, myocardial fibrosis and heart failure in aortic valve stenosis. | BACKGROUND AND AIM OF THE STUDY: Myocardial fibrosis predisposes to heart failure in aortic valve stenosis. The study aim was to determine the value of: (i) circulating collagen metabolites as biomarkers of left ventricular fibrosis and heart failure in aortic stenosis; and (ii) myocardial fibrosis as a predictor of po... | ['Adult', 'Aged', 'Aged, 80 and over', 'Aortic Valve Stenosis', 'Biomarkers', 'Case-Control Studies', 'Collagen Type I', 'Female', 'Fibrosis', 'Heart Failure', 'Heart Ventricles', 'Humans', 'Male', 'Middle Aged', 'Myocardium', 'Peptide Fragments', 'Peptides', 'Procollagen'] | 23,798,204 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.484.048.750', 'C14.280.955.249'], ['D23.101'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['C23.550.355'], ['C14.280.434'], ['A07.541.560'], ['B01.050... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The gap junction blocker carbenoxolone attenuates nociceptive behavior and medullary dorsal horn central sensitization induced by partial infraorbital nerve transection in rats. | Glial cells are being increasingly implicated in mechanisms underlying pathological pain, and recent studies suggest glial gap junctions involving astrocytes may contribute. The aim of this study was to examine the effect of a gap junction blocker, carbenoxolone (CBX), on medullary dorsal horn (MDH) nociceptive neurona... | ['Animals', 'Carbenoxolone', 'Facial Pain', 'Gap Junctions', 'Injections, Spinal', 'Male', 'Neuralgia', 'Pain Measurement', 'Posterior Horn Cells', 'Rats', 'Rats, Sprague-Dawley'] | 24,239,671 | [['B01.050'], ['D02.455.849.919.530.444.250'], ['C23.888.592.612.330'], ['A11.284.149.165.420.471'], ['E02.319.267.530.580'], ['C10.668.829.600', 'C23.888.592.612.664'], ['E01.370.600.550.324'], ['A08.186.854.697.500', 'A08.675.650.675', 'A11.671.650.675'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cold ischaemia, innate immunity and deterioration of the glomerular filtration barrier in antibody-mediated acute rejection. | BACKGROUND: In renal transplantation, cold ischaemia (CI) determines acute rejection through innate immunity among others. Acute rejection episodes are a risk factor for late allograft dysfunction and proteinuria. This implies some alteration of the glomerular filtration barrier (GFB). Besides its effects on acute reje... | ['Acute Disease', 'Adaptive Immunity', 'Animals', 'Cold Ischemia', 'Collagen Type IV', 'Disease Models, Animal', 'Gene Expression', 'Glomerular Filtration Barrier', 'Graft Rejection', 'Immunity, Innate', 'Isoantibodies', 'Kidney Transplantation', 'Male', 'Myeloid Differentiation Factor 88', 'Rats', 'Rats, Inbred BN', '... | 22,555,253 | [['C23.550.291.125'], ['G12.450.050'], ['B01.050'], ['E04.936.337', 'E05.760.833.445'], ['D12.776.860.300.250.400.100'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.297'], ['A05.810.453.324.359.372', 'A05.810.453.736.520.372', 'A07.500'], ['G12.875.545.328'], ['G12.450.564'], ['D12.776.124.486.485.114.664', 'D... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dynamic contrast enhanced MR imaging for evaluation of angiogenesis of hepatocellular nodules in liver cirrhosis in N-nitrosodiethylamine induced rat model. | PURPOSE: To investigate whether dynamic contrast -enhanced MRI (DCE-MRI) can distinguish the type of liver nodules in a rat model with N-nitrosodiethylamine- induced cirrhosis.METHODS: Liver nodules in cirrhosis were induced in 60 male Wistar rats via 0.01 % N-nitrosodiethylamine in the drinking water for 35-100 days. ... | ['Angiography', 'Animals', 'Carcinoma, Hepatocellular', 'Contrast Media', 'Diethylnitrosamine', 'Disease Models, Animal', 'Early Detection of Cancer', 'Humans', 'Liver Cirrhosis', 'Liver Neoplasms', 'Magnetic Resonance Imaging', 'Male', 'Neovascularization, Pathologic', 'ROC Curve', 'Rats', 'Rats, Wistar'] | 27,488,851 | [['E01.370.350.700.060', 'E01.370.370.050'], ['B01.050'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D27.505.259.500', 'D27.720.259'], ['D02.654.442.200'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.390.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Central foveal thickness before and after cataract surgery in normal and in diabetic patients without retinopathy. | BACKGROUND: This study aims to evaluate and compare central foveal thickness (CFT) changes after cataract surgery between normal and diabetic patients without retinopathy, using optical coherence tomography (OCT).PATIENTS AND METHODS: Ninety-eight patients (49 patients with type 2 diabetes and 49 healthy controls, sex-... | ['Aged', 'Aged, 80 and over', 'Cataract', 'Cataract Extraction', 'Diabetes Complications', 'Diabetic Retinopathy', 'Female', 'Fovea Centralis', 'Humans', 'Male', 'Middle Aged', 'Postoperative Period', 'Preoperative Care', 'Prognosis', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Tomography, Optical Coh... | 22,495,998 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C11.510.245'], ['E04.540.825.249'], ['C19.246.099'], ['C11.768.257', 'C14.907.320.382', 'C19.246.099.500.382'], ['A09.371.729.522.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.614.750', 'N02.421.585.753.750'], ['E02.760.795', 'E04.604... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Impact of enhancements in the local effect model (LEM) on the predicted RBE-weighted target dose distribution in carbon ion therapy. | Biological optimization for treatment planning in carbon ion therapy is currently based on the first version of the local effect model (LEM I). Further developments implemented in the latest version (LEM IV) allowed to predict more accurately the Relative Biological Effectiveness (RBE) in-vitro. The main goal of this s... | ['Carbon', 'Humans', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted', 'Relative Biological Effectiveness'] | 23,075,883 | [['D01.268.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.815.639'], ['E02.950.825', 'L01.313.500.750.100.710.600.608'], ['N06.850.810.250.275']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Are routine clinical chemistry analyses 'in control' according to Shewhart's technique? | The clinical laboratory routinely uses quality control (QC) procedures. The Shewhart technique of charting control data, introduced in 1950, is usually applied in a much simplified manner. This reduces its power to distinguish between random errors and errors due to assignable causes. In a comparison of one of our rout... | ['Diagnostic Tests, Routine', 'Humans', 'Quality Control', 'Reference Values'] | 4,059,723 | [['E01.370.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.608'], ['E05.978.810']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Pandemic influenza and major disease outbreak preparedness in US emergency departments: A selected survey of emergency health professionals. | OBJECTIVE: To assess the level of pandemic preparedness at emergency departments (EDs) around the country and to better understand current barriers to preparedness in the United States represented by health professionals in the American College of Emergency Physician (ACEP) Disaster Medicine Section (DMS). Methods, des... | ['Attitude of Health Personnel', 'Cross-Sectional Studies', 'Disaster Planning', 'Disease Outbreaks', 'Emergency Service, Hospital', 'Humans', 'Influenza, Human', 'Pandemics', 'Physicians', 'Surveys and Questionnaires', 'United States'] | 32,803,746 | [['F01.100.050', 'N05.300.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N06.230.100.035'], ['N06.850.290'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.748.310', 'C01.925.782.620.365', 'C08.73... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Permanent transvenous left ventricular endocardial pacing in a patient with univentricular atrioventricular connection. | Chronotropic incompetence is associated with poorer effort tolerance and worse mortality outcomes, not only in the general cardiac population but also in patients with congenital heart disease. When present in complex patients, pacing options may be limited by difficult pacing access, and an open surgical approach for ... | ['Adult', 'Arrhythmias, Cardiac', 'Cardiac Pacing, Artificial', 'Electrocardiography', 'Endocardium', 'Heart Defects, Congenital', 'Humans', 'Male', 'Palliative Care', 'Treatment Outcome'] | 21,545,465 | [['M01.060.116'], ['C14.280.067', 'C23.550.073'], ['E02.331.200'], ['E01.370.370.380.240', 'E01.370.405.240'], ['A07.541.207'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.666', 'N02.421.585.666'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Rapidly developing multimorbidity and disability in older adults: does social background matter? | BACKGROUND: Multimorbidity is among the most disabling geriatric conditions. In this study, we explored whether a rapid development of multimorbidity potentiates its impact on the functional independence of older adults, and whether different sociodemographic factors play a role beyond the rate of chronic disease accum... | ['Aged', 'Aged, 80 and over', 'Chronic Disease', 'Disabled Persons', 'Female', 'Humans', 'Male', 'Middle Aged', 'Multimorbidity', 'Sampling Studies', 'Sex Factors', 'Social Networking', 'Sweden', 'Time Factors'] | 29,415,323 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.291.500'], ['M01.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N05.715.350.225.500', 'N06.850.490.687.500'], ['E05.318.372.875', 'N05.715.360.330.875', 'N06.850.520.450.875'], ['N05.715.350.675', 'N06.850.490.875'], ['L01.143.910'... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
[Teratogenic and goitrogenic activity of propineb and propylenethiourea in the rat]. | The teratogenic and goitrogenic effects of Propineb, dithiocarbamate pesticide and Propylenthiourea (PLTU), its metabolite and degradation product have been studied. The aim of this study was to show the possible correlation between the two activities. Female Sprague-Dawley rats were treated with Propineb and PLTU star... | ['Animals', 'Antithyroid Agents', 'Female', 'Fungicides, Industrial', 'Pregnancy', 'Pregnancy Complications', 'Rats', 'Rats, Inbred Strains', 'Teratogens', 'Thiocarbamates', 'Thiourea', 'Zineb'] | 2,581,594 | [['B01.050'], ['D06.347.100', 'D27.505.696.399.450.100'], ['D27.720.031.700.288', 'D27.888.723.288'], ['G08.686.784.769'], ['C13.703'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D27.888.569.864'], ['D02.241.081.251.869', 'D02.886.706'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of a myeloid intrathymic pathway of dendritic cell development marked by expression of the granulocyte macrophage-colony-stimulating factor receptor. | In this study, the finding that a significant proportion of all dendritic cells (DCs) resident in vivo in the human postnatal thymus displayed a myeloid-related phenotype prompted us to re-examine the developmental origin of thymic DCs, a cell type hitherto considered to represent a homogeneous lymphoid-derived populat... | ['Antigens, CD', 'Antigens, CD34', 'Biomarkers', 'Cell Differentiation', 'Cell Lineage', 'Dendritic Cells', 'Gene Expression Regulation', 'Genes, T-Cell Receptor alpha', 'Humans', 'Immunophenotyping', 'Myeloid Progenitor Cells', 'Receptors, Granulocyte-Macrophage Colony-Stimulating Factor', 'Receptors, Interleukin-7', ... | 11,929,786 | [['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['D23.101'], ['G04.152'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['G05.308'], ['G05.360.340.024.340.475.050'],... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accuracy of simple plain radiographic signs and measures to diagnose acute scapholunate ligament injuries of the wrist. | OBJECTIVE: To determine the accuracy of common radiological indices for diagnosing ruptures of the scapholunate (SL) ligament, the most relevant soft tissue injury of the wrist.METHODS: This was a prospective diagnostic accuracy study with independent verification of index test findings by a reference standard (wrist a... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Humans', 'Ligaments, Articular', 'Male', 'Middle Aged', 'Observer Variation', 'Predictive Value of Tests', 'Prospective Studies', 'Radiography', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Wrist Injuries', 'Wrist Joint', 'Young Adult'] | 25,981,221 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.513.514', 'A02.835.583.512', 'A10.165.669.514'], ['M01.060.116.630'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.8... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pose prediction and virtual screening performance of GOLD scoring functions in a standardized test. | The performance of all four GOLD scoring functions has been evaluated for pose prediction and virtual screening under the standardized conditions of the comparative docking and scoring experiment reported in this Edition. Excellent pose prediction and good virtual screening performance was demonstrated using unmodified... | ['Algorithms', 'Binding Sites', 'Computer Simulation', 'Ligands', 'Models, Molecular', 'Protein Binding', 'Protein Conformation', 'Proteins', 'Software', 'Solutions'] | 22,371,207 | [['G17.035', 'L01.224.050'], ['G02.111.570.120'], ['L01.224.160'], ['D27.720.470.480'], ['E05.599.595'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709'], ['D12.776'], ['L01.224.900'], ['D26.776']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
An approximate likelihood for genetic data under a model with recombination and population splitting. | We describe a new approximate likelihood for population genetic data under a model in which a single ancestral population has split into two daughter populations. The approximate likelihood is based on the 'Product of Approximate Conditionals' likelihood and 'copying model' of Li and Stephens [Li, N., Stephens, M., 200... | ['Likelihood Functions', 'Linkage Disequilibrium', 'Models, Theoretical', 'Polymorphism, Single Nucleotide', 'Population Dynamics', 'Recombination, Genetic'] | 19,362,099 | [['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.520.830.600.400'], ['G05.348.500'], ['E05.599'], ['G05.365.795.598'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['G05.728']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Further studies on liver glyoxalase I and glyoxalase II. Activity in mice bearing sarcoma 180 and L1210 leukemia. | Determinations were made of glyoxalase I and glyoxalase II acitivity in the liver of mice (BDF1 and DBA2 strains) bearing sarcoma 180 and L1210 leukemia in ascites form. A progressive decrease in the both glyoxalase I and glyoxalase II activities to about 40--60% of that of the control groups was observed within the de... | ['Animals', 'Cell Division', 'Glutathione', 'Lactoylglutathione Lyase', 'Leukemia L1210', 'Liver', 'Lyases', 'Mice', 'Mice, Inbred Strains', 'Sarcoma 180', 'Thiolester Hydrolases', 'Time Factors'] | 692,805 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D12.644.456.448'], ['D08.811.520.300.500'], ['C04.557.337.372.594', 'C04.619.531.594'], ['A03.620'], ['D08.811.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.50... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of monohydroxylated metabolites of cannabidiol formed by rat liver. | Cannabidiol (CBD) was metabolized in vitro by rat liver enzymes. Unchanged CBD and eight monohydroxylated metabolites were isolated and positively identified. As previously reported, 7-hydroxy-CBD was the major metabolite. The second most abundant metabolite was 6alpha-hydroxy-CBD; whereas only a trace amount of 6beta-... | ['Animals', 'Cannabidiol', 'Cannabis', 'Chromatography, Thin Layer', 'Hydroxylation', 'In Vitro Techniques', 'Liver', 'Male', 'Mass Spectrometry', 'Rats'] | 6,714 | [['B01.050'], ['D02.455.849.090.100'], ['B01.650.940.800.575.912.250.859.937.055.500'], ['E05.196.181.400.537'], ['G02.111.385', 'G02.607.348', 'G03.425'], ['E05.481'], ['A03.620'], ['E05.196.566'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Unprecedented forms of vanadium observed within the blood cells of Phallusia nigra using K-edge X-ray absorption spectroscopy. | Fits to the vanadium K-edge X-ray absorption spectra (XAS) of five whole blood cell samples from the tunicate Phallusia nigra revealed unprecedented forms of intracellular vanadium. Endogenous vanadium was divided between the V(III) ion (74.2+/-5.1% of total V) and the vanadyl ion [V(IV)=O](2+) (25.2+/-5.4% of total V)... | ['Animals', 'Blood Cells', 'Electron Spin Resonance Spectroscopy', 'Spectrum Analysis', 'Urochordata', 'Vanadium', 'X-Rays'] | 11,583,781 | [['B01.050'], ['A11.118', 'A15.145.229'], ['E05.196.867.519.274'], ['E05.196.867'], ['B01.050.150.200.727', 'B01.050.500.272.727'], ['D01.268.556.920', 'D01.268.956.886', 'D01.552.544.920'], ['G01.358.500.505.970', 'G01.750.250.970', 'G01.750.750.918']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The arsenite oxidase genes (aroAB) in novel chemoautotrophic arsenite oxidizers. | Six novel bacterial strains were isolated from the environment which can oxidize arsenite [As(III)] to the less mobile form arsenate [As(V)] coupled to CO(2) fixation under either aerobic or denitrifying conditions. PCR primers were designed to the conserved molybdopterin domain of the large subunit of arsenite oxidase... | ['Agrobacterium tumefaciens', 'Amino Acid Sequence', 'Arsenites', 'Carbon Monoxide', 'Molecular Sequence Data', 'Oxidation-Reduction', 'Oxidoreductases', 'Phylogeny', 'Polymerase Chain Reaction'] | 17,257,587 | [['B03.440.400.425.700.024.050', 'B03.660.050.662.024.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D01.075.050', 'D01.248.497.158.055'], ['D01.200.250', 'D01.362.200', 'D01.650.550.250'], ['L01.453.245.667'], ['G02.700', 'G03.295.531'], ['D08.811.682'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.620.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The ectodermal dysplasia receptor represses the Lef-1/beta-catenin-dependent transcription independent of NF-kappaB activation. | EDAR plays a key role in the process of ectodermal differentiation via activation of the NF-kappaB pathway. We present evidence that EDAR also represses Lef-1/beta-catenin-dependent transcription and this ability is defective in EDAR mutants associated with anhidrotic ectodermal dysplasia. While IKK1/IKKalpha and IKK2/... | ['Animals', 'Cell Line', 'Cytoskeletal Proteins', 'DNA-Binding Proteins', 'Ectodermal Dysplasia', 'Edar Receptor', 'Genes, Reporter', 'Genetic Vectors', 'Humans', 'I-kappa B Kinase', 'Luciferases', 'Lymphoid Enhancer-Binding Factor 1', 'Membrane Proteins', 'Mice', 'NF-kappa B', 'Protein-Serine-Threonine Kinases', 'Rece... | 15,013,427 | [['B01.050'], ['A11.251.210'], ['D12.776.220'], ['D12.776.260'], ['C16.131.077.350', 'C16.131.831.350', 'C16.320.850.250', 'C17.800.804.350', 'C17.800.827.250'], ['D12.776.543.750.690.550', 'D12.776.543.750.705.852.760.347.500'], ['G05.360.340.024.340.435'], ['G05.360.337'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pentacyclic triterpenes from Chrysobalanaceae species: cytotoxicity on multidrug resistant and sensitive leukemia cell lines. | Plants are known as important source in the search for new anti-cancer agents. Cytotoxicity-guided fractionation of leaves and fruits from Licania tomentosa Bench and leaves from Chrysobalanus icaco L. resulted in the isolation of betulinic, oleanolic and pomolic acids. These triterpenoids inhibited the growth and indu... | ['Apoptosis', 'Cell Division', 'Drug Resistance, Neoplasm', 'Humans', 'K562 Cells', 'Leukemia', 'Plant Extracts', 'Rosales', 'Triterpenes', 'Tumor Cells, Cultured', 'Vincristine'] | 12,565,171 | [['G04.146.954.035'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G07.690.773.984.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.510', 'A11.251.860.180.510', 'A11.443.240.497.480'], ['C04.557.337'], ['D20.215.784.500', 'D26.667'], ['B01.650.940.800.575.912.250.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Juvenile psoriasis in European and Asian children: similarities and differences. | BACKGROUND: The first manifestations of psoriasis begin in childhood in more than one-third of patients. However, epidemiological data of juvenile psoriasis are lacking.OBJECTIVES: To compare Dutch (NL group) and Singaporean (SG group) children with psoriasis with the aim of studying the characteristics of juvenile pso... | ['Adolescent', 'Age of Onset', 'Asian Continental Ancestry Group', 'Child', 'Child, Preschool', 'European Continental Ancestry Group', 'Female', 'Humans', 'Male', 'Netherlands', 'Psoriasis', 'Risk Factors', 'Singapore'] | 21,418,172 | [['M01.060.057'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.686.508.200'], ['M01.060.406'], ['M01.060.406.448'], ['M01.686.508.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.651'], ['C17.800.859.675'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Dialectic of the daily life of patients with chronic kidney failure: the unavoidable and the casual]. | The objective of this study was to understand the social reality of patients' daily life with chronic renal failure in hemodialysis. To understand this phenomenon from the theoretical-methodological referential of the historic and dialectic materialism. The interviews were performed with 18 patients submitted to analys... | ['Humans', 'Kidney Failure, Chronic', 'Quality of Life', 'Renal Dialysis'] | 14,686,045 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E02.870.300', 'E02.912.800']] | ['Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Identification of sources contributing to PM2.5 and ozone at elevated sites in the western U.S. by receptor analysis: Lassen Volcanic National Park, California, and Great Basin National Park, Nevada. | The proposed revision of the United States (US) air quality standard for ozone will result in violations in sparsely populated remote rural areas in the Western US. Replicating air quality as measured at surface monitoring sites by modeling is particularly difficult in this region due to complex terrain, poorly represe... | ['Aerosols', 'Air Pollutants', 'Air Pollution', 'California', 'Environmental Monitoring', 'Models, Chemical', 'Nevada', 'Ozone', 'Particulate Matter'] | 25,864,796 | [['D20.280.055', 'D26.255.165.055'], ['D27.888.284.101'], ['N06.850.460.100'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['N06.850.460.350.080', 'N06.850.780.375'], ['E05.599.495'], ['Z01.107.567.875.760.550'], ['D01.362.670.600'], ['D20.633']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Hyper-insulinemia increases the glutamate-excitotoxicity in cortical neurons: A mechanistic study. | Insulin resistance in type-2 diabetic condition increases the risk of stroke and cognitive deficits in which involvement of glutamate has been postulated. It has been hypothesized that hyper-insulinemia in cortical neurons increases the vulnerability towards glutamate-induced excitotoxicity. To mimic insulin resistance... | ['Animals', 'Carrier Proteins', 'Cerebral Cortex', 'Cytoskeletal Proteins', 'Glutamic Acid', 'Glycogen Synthase Kinase 3 beta', 'Indoles', 'Insulin', 'Insulin Resistance', 'Maleimides', 'Models, Animal', 'Neuronal Plasticity', 'Neurons', 'Nuclear Proteins', 'Peptides', 'Phosphorylation', 'Proto-Oncogene Proteins c-akt'... | 30,017,861 | [['B01.050'], ['D12.776.157'], ['A08.186.211.200.885.287.500'], ['D12.776.220'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['D05.500.117.875.500', 'D08.811.913.696.620.682.700.429.500.500', 'D08.811.913.696.620.682.700.646.625.500', 'D12.644.360.300.500.500', 'D12.776.476.081.875.500', 'D12.776... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nanopore analysis of amyloid fibrils formed by lysozyme aggregation. | The measurement of single particle size distributions of amyloid fibrils is crucial for determining mechanisms of growth and toxicity. Nanopore sensing is an attractive solution for this problem since it gives information on aggregates' shapes with relatively high throughput for a single particle technology. In this pa... | ['Amyloid', 'Muramidase', 'Nanopores'] | 25,994,201 | [['D05.500.049', 'D12.776.049'], ['D08.811.277.450.642'], ['J01.637.512.650']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Assessing potential predisposition of elementary school children to heart disease. | Physical well-being has been designated a top priority for the children in the Clovis (California) Unified School District. In an effort to diminish coronary risk factors and encourage a healthy life style, a health assessment battery was developed for students in grades 1 through 6. The battery included measurements i... | ['Adult', 'Age Factors', 'Blood Pressure', 'Body Height', 'Body Weight', 'California', 'Child', 'Child, Preschool', 'Female', 'Heart Diseases', 'Humans', 'Hypertension', 'Male', 'Mass Screening', 'Obesity'] | 6,925,092 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'],... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Recognition of carboxylate anions and carboxylic acids by selenium-based new chromogenic fluorescent sensor: a remarkable fluorescence enhancement of hindered carboxylates. | A selenium metal-based new fluorescence sensor 5-pivaloylamino-1,2,5-selenodiazolo[3,4-d]pyrimidin-7-(6H)-one (receptor 1) has been reported for the recognition of monocarboxylic acids and carboxylate anions both by UV-vis and fluorescence methods. Receptor 1 recognizes carboxylate anions more than monocarboxylic acids... | ['Carboxylic Acids', 'Crystallography, X-Ray', 'Fluorescence', 'Fluorescent Dyes', 'Models, Molecular', 'Molecular Structure', 'Organoselenium Compounds'] | 19,728,733 | [['D02.241'], ['E05.196.309.742.225'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['D02.731']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Risk factors and impact of orthopaedic monitoring on the outcome of avascular necrosis of the femoral head in adults with sickle cell disease: 215 patients case study with control group. | INTRODUCTION: Sickle cell disease is a public health problem. The WHO has recommended that global management be implemented to reduce mortality and morbidity. Since no comprehensive care programme for bone and joint complications exists, the Caribbean Sickle Cell Disease Center added orthopaedic consultation to screen ... | ['Adolescent', 'Adult', 'Age Distribution', 'Anemia, Sickle Cell', 'Caribbean Region', 'Disease Progression', 'Female', 'Femur Head Necrosis', 'Follow-Up Studies', 'Hemoglobins', 'Humans', 'Incidence', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Orthopedic Procedures', 'Prognosis', 'Referral and Consultation'... | 22,079,613 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['Z01.107.084'], ['C23.550.291.656'], ['C05.116.852.175', 'C23.550.717.732.368'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N0... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The stress on the anterior lens surface during human in vivo accommodation. | PURPOSE: To determine the qualitative change in stress on the lens capsule during in vivo human accommodation.METHODS: Nine subjects (mean age: 30 years; range: 25-38 years) were studied, each of whom had undergone a phakic refractive intraocular lens (PRL) surgical procedure. The change, during accommodation, of stres... | ['Accommodation, Ocular', 'Adult', 'Female', 'Humans', 'Lens Capsule, Crystalline', 'Male', 'Stress, Mechanical', 'Tomography, Optical Coherence'] | 18,211,940 | [['G14.010'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.371.060.500.155'], ['G01.374.835'], ['E01.370.350.589.249.500', 'E01.370.350.825.805.500', 'E05.642.249.500']] | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Diverticulitis of the colon. Clinical review of acute presentations and management. | A series of 46 patients treated surgically for acute sequelae of diverticular disease of the colon was reviewed. Perforation of sigmoid diverticulitis and colon obstruction were the most common indications for surgical treatment. Resection of the involved colon was carried out in 44 of 46 patients. Primary resection wa... | ['Adult', 'Aged', 'Colonic Diseases', 'Diverticulitis, Colonic', 'Female', 'Humans', 'Intestinal Obstruction', 'Intestinal Perforation', 'Male', 'Middle Aged', 'Postoperative Complications', 'Retrospective Studies'] | 7,081,565 | [['M01.060.116'], ['M01.060.116.100'], ['C06.405.469.158'], ['C06.405.205.282.500.250', 'C06.405.469.158.587.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.531'], ['C06.405.469.557'], ['M01.060.116.630'], ['C23.550.767'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Colchicine attenuates renal injury in a model of hypertensive chronic kidney disease. | Hypertension is a risk factor for chronic kidney disease, particularly when associated with impaired renal autoregulation and thereby increased intraglomerular pressure (Pgc). Elevated Pgc can be modeled in vitro by exposing glomerular mesangial cells to mechanical strain. We previously showed that RhoA mediates strain... | ['Animals', 'Cells, Cultured', 'Colchicine', 'Collagen Type I', 'Connective Tissue Growth Factor', 'Cytoprotection', 'Disease Models, Animal', 'Enzyme Activation', 'Fibronectins', 'Fibrosis', 'Hypertension, Renal', 'Kidney', 'Male', 'Microtubules', 'Nephrectomy', 'Nephritis', 'Phosphorylation', 'Promoter Regions, Genet... | 23,946,291 | [['B01.050'], ['A11.251'], ['D03.132.225'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['D12.644.276.200.100', 'D12.776.467.200.100', 'D12.776.860.300.200.100', 'D23.529.237.100'], ['G07.690.773.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G02.111.263', 'G03.328'], ['D12.776.377.715.390', 'D... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The antithrombotic effect of heparin in deep venous thrombosis: relation to four heparin assays. | In a prospective study, 280 patients with phlebographically proven deep venous thrombosis received intravenous heparin infusion; 224 of the patients were subjected to control phlebography after 5-8 days of treatment. Females above 70 years showed least phlebographic improvement despite similar heparin dosage and hepari... | ['Aged', 'Blood Coagulation Tests', 'Female', 'Heparin', 'Humans', 'Male', 'Middle Aged', 'Phlebography', 'Prospective Studies', 'Pulmonary Embolism', 'Thrombophlebitis'] | 6,496,186 | [['M01.060.116.100'], ['E01.370.225.625.115', 'E05.200.625.115'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.700.060.600', 'E01.370.370.050.600'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['C08.381.746', 'C14... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Factors controlling drug reinforced behavior. | An overview is provided of factors controlling drug reinforced behavior. Drug reinforced behavior is defined, and control procedures for rigorously identifying such behavior are discussed. Factors affecting drug reinforced behavior include the drug itself, animal species, route of administration, current circumstance v... | ['Animals', 'Conditioning, Operant', 'Disease Models, Animal', 'Humans', 'Psychotropic Drugs', 'Reinforcement, Psychology', 'Self Administration', 'Self Medication', 'Substance-Related Disorders'] | 3,628,452 | [['B01.050'], ['F02.463.425.179.509'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.954.427.700'], ['F02.463.425.770'], ['E02.319.890', 'E02.900.890'], ['E02.319.900', 'E02.900.900'], ['C25.775', 'F03.900']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Level-specific amputations and resulting regenerative outcomes in the mouse distal phalanx. | Mouse digit tip regeneration involves an intricate coordinated regrowth of the terminal phalanx, nail, dermis and epidermis. During this time, regenerating digits undergo wound healing, blastema formation, and differentiation. However, the regenerative response of the digit is dependent on the level of the amputation. ... | ['Amputation', 'Animals', 'Apoptosis', 'Cell Differentiation', 'Disease Models, Animal', 'Hindlimb', 'Hoof and Claw', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Osteoclasts', 'Regeneration', 'Toe Phalanges', 'Wound Healing'] | 28,493,324 | [['E04.555.080'], ['B01.050'], ['G04.146.954.035'], ['G04.152'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A13.473'], ['A13.491'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['A11.329.372.700', 'A11.627.482.700'], ['G16.762'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Montanide IMS 1312 VG adjuvant enhances the efficacy of immersion vaccine of inactivated viral hemorrhagic septicemia virus (VHSV) in olive flounder, Paralichthys olivaceus. | Vaccination by immersion is suitable for mass vaccination of small size fish. However, no viral vaccine has been developed for immersion applications, because of low efficacy. In this study, we evaluated the efficacy and safety of immersion vaccine against viral hemorrhagic septicemia (VHS) containing Montanide IMS 131... | ['Adjuvants, Immunologic', 'Animals', 'Cytokines', 'Fish Proteins', 'Flatfishes', 'Hemorrhagic Septicemia, Viral', 'Novirhabdovirus', 'Toll-Like Receptors', 'Vaccination', 'Viral Vaccines'] | 27,965,163 | [['D27.505.696.477.067'], ['B01.050'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D12.776.325'], ['B01.050.150.900.493.418'], ['C01.925.782.580.830.450', 'C22.362.450', 'C23.550.470.790.500.900.400'], ['B04.820.480.937.750.600'], ['D12.776.543.750.705.910.500'], ['E02.095.465.425.400.530.890', 'E05.478.55... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Experimental observations of the hydrodynamic behavior of solvent systems in high-speed counter-current chromatography. I. Hydrodynamic distribution of two solvent phases in a helical column subjected to two types of synchronous planetary motion. | Hydrodynamic distribution of two-phase solvent systems in a rotating helical column subjected to centrifugal fields produced by two different types of synchronous planetary motion has been studied by the use of the combined horizontal flow-through coil planet centrifuge. With continuous elution of the mobile phase, the... | ['Chromatography, High Pressure Liquid', 'Solvents'] | 6,501,495 | [['E05.196.181.400.300'], ['D27.720.844']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Total glenohumeral joint replacement. | Some of the anatomical considerations of the glenohumeral joint with respect to prosthetic replacement have been discussed. One approach to prosthetic design has been presented along with the early clinical experience with this design. It is hoped that this information will serve as a reference point for future work to... | ['Adult', 'Aged', 'Arthropathy, Neurogenic', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Humeral Fractures', 'Humerus', 'Joint Prosthesis', 'Male', 'Metals', 'Middle Aged', 'Polyethylenes', 'Scapula', 'Shoulder', 'Shoulder Joint'] | 1,128,882 | [['M01.060.116'], ['M01.060.116.100'], ['C05.550.186'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.088.390', 'C26.404.500'], ['A02.835.232.087.090.400'], ['E07.695.400'], ['D01.552'], ['M01.060.116.630'], ['D02.455.326.271.665.550', 'D05.750.716.507', 'D25.720.716.507', 'J01.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
The ten-year pattern of hip diseases in Singapore. | PURPOSE: To review patients with hip diseases undergoing total hip arthroplasty (THA) during 2 different periods.METHODS: During the periods 1994 to 1996 and 2004 to 2006, 12 men and 28 women (mean age, 57 years) and 55 men and 78 women (mean age, 62 years) underwent THA for hip diseases, respectively. The aetiologies ... | ['Arthroplasty, Replacement, Hip', 'Asian Continental Ancestry Group', 'Cohort Studies', 'Female', 'Hip Joint', 'Humans', 'Incidence', 'Joint Diseases', 'Male', 'Middle Aged', 'Retrospective Studies', 'Singapore', 'Time Factors'] | 21,187,534 | [['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['M01.686.508.200'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Segment-directed mutagenesis: construction in vitro of point mutations limited to a small predetermined region of a circular DNA molecule. | A general method for efficiently mutagenizing a predetermined segment of a closed circular duplex DNA molecule was used to construct mutations in two specific regions of the beta-lactamase (bla) gene carried by the small plasmid pBR322. The principle of segment-directed mutagenesis is the use of a single-stranded homol... | ['Base Sequence', 'DNA Restriction Enzymes', 'DNA, Circular', 'DNA, Single-Stranded', 'Escherichia coli', 'Genetic Techniques', 'Micrococcal Nuclease', 'Mutation', 'Plasmids', 'Sulfites', 'beta-Lactamases'] | 6,254,078 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['D13.444.308.283', 'G02.111.570.820.486.212', 'G05.360.580.156'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['B03.440.450.425.325.300', 'B03.660.250.15... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Phlebitis induced by parenteral treatment with flucloxacillin and cloxacillin: a double-blind study. | Two studies were performed on a total of 54 patients with staphylococcal infections. Study I compares with phlebitogenic properties of flucloxacillin after intravenous infusions when either saline or sterile water was used as a solvent. No difference was observed between the two solvents, and the frequency of phlebitis... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Cloxacillin', 'Double-Blind Method', 'Female', 'Floxacillin', 'Humans', 'Infusions, Parenteral', 'Male', 'Middle Aged', 'Phlebitis', 'Staphylococcal Infections'] | 7,447,412 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['D02.065.589.099.750.625.150', 'D02.886.108.750.625.150', 'D03.633.100.300.750.625.150'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D02.065.589.099.750.625.150.250', 'D02.886.108.750.625.150.250', 'D0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hypermetropia-succeeded myopia after hyperbaric oxygen therapy. | A 58-year-old man presented with a change in vision during hyperbaric oxygen (HBO) therapy. Subsequent follow-up visits showed a hypermetropic shift, which succeeded the myopic shift after each of two series of HBO treatments. The maximal refractive amplitude was 3.00 D (range -1.37 D to +1.62 D) in the right eye and 2... | ['Follow-Up Studies', 'Humans', 'Hyperbaric Oxygenation', 'Hyperopia', 'Male', 'Middle Aged', 'Myopia', 'Refraction, Ocular'] | 16,534,462 | [['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.880.690.490'], ['C11.744.479'], ['M01.060.116.630'], ['C11.744.636'], ['E01.370.380.850.700', 'G01.590.775', 'G14.760']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Surgical repair of cleft palate in the horse. | Surgical repair of a cleft palate was carried out in three horses. Mandibular symphisotomy allowed adequate exposure of the defect. The first subject, a young foal died from inhalation pneumonia but the other two made satisfactory recoveries. The problems of closure of the lip and symphysis are discussed. | ['Anesthesia, Inhalation', 'Animals', 'Cleft Palate', 'Escherichia coli Infections', 'Female', 'Halothane', 'Horse Diseases', 'Horses', 'Infusions, Parenteral', 'Male', 'Oxygen', 'Pneumonia', 'Postoperative Complications', 'Sepsis', 'Sutures', 'Tracheotomy'] | 1,095,366 | [['E03.155.197.197'], ['B01.050'], ['C05.500.460.185', 'C05.660.207.540.460.185', 'C07.320.440.185', 'C07.465.525.185', 'C07.650.500.460.185', 'C07.650.525.185', 'C16.131.621.207.540.460.185', 'C16.131.850.500.460.185', 'C16.131.850.525.185'], ['C01.150.252.400.310.330'], ['D02.455.526.340'], ['C22.488'], ['B01.050.150... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ordered conformational changes in damaged DNA induced by nucleotide excision repair factors. | In response to genotoxic attacks, cells activate sophisticated DNA repair pathways such as nucleotide excision repair (NER), which consists of damage removal via dual incision and DNA resynthesis. Using permanganate footprinting as well as highly purified factors, we show that NER is a dynamic process that takes place ... | ['Adenosine Triphosphate', 'DNA', 'DNA Damage', 'DNA Repair', 'DNA Repair Enzymes', 'DNA-Binding Proteins', 'Endonucleases', 'Humans', 'Nuclear Proteins', 'Nucleic Acid Conformation', 'Replication Protein A', 'Transcription Factor TFIIH', 'Transcription Factors', 'Transcription Factors, TFII', 'Xeroderma Pigmentosum Gr... | 14,981,083 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D13.444.308'], ['G05.200'], ['G02.111.222', 'G05.219'], ['D08.811.074'], ['D12.776.260'], ['D08.811.277.352.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.660'], ['G02.111.570.820.486', 'G05.360.580'], ['D12.776.260.700... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression of a cDNA clone corresponding to the long open reading frame (XBL-I) of the bovine leukemia virus. | Nucleotide sequence analysis of a cDNA clone corresponding to the XBL-I open reading-frame of bovine leukemia virus (BLV) revealed that the AUG initiation codon was located 44 bases downstream from that of the env gene and was part of the p34x mRNA splice donor. . .ATGG/GTAA at the end of the pol gene sequence. RNA fro... | ['Base Sequence', 'DNA', 'DNA, Recombinant', 'Leukemia Virus, Bovine', 'RNA, Viral', 'Recombinant Proteins', 'Retroviridae', 'Viral Proteins'] | 2,820,139 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308'], ['D13.444.308.460'], ['B04.613.807.200.600', 'B04.820.650.200.600'], ['D13.444.735.828'], ['D12.776.828'], ['B04.613.807', 'B04.820.650'], ['D12.776.964']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Plasticity of lateralization: schooling predicts hand preference but not hand skill asymmetry in a non-industrial society. | Considerable variation in the frequency of left-handedness between cultures has been reported, ranging from 0.5 to 24%. This variation in hand preference may have evolved under natural or cultural selection. It has been suggested that schooling affects handedness but as in most human societies only a selected and minor... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Analysis of Variance', 'Child', 'Child, Preschool', 'Female', 'Functional Laterality', 'Hand', 'Hand Strength', 'Humans', 'Male', 'Middle Aged', 'Muscle Strength Dynamometer', 'Predictive Value of Tests', 'Psychomotor Performance', 'Reaction Time', 'Sex Factors', 'Young A... | 22,230,229 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['M01.060.406'], ['M01.060.406.448'], ['F02.830.297.425', 'G11.561.225.425'], ['A01.378.800.667'], ['E01.370.600.425.500', 'G11.427.560.500'], ['B01.050.150.... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Strategy Configurations Directly Linked to Higher Hepatitis C Virus Treatment Starts: An Applied Use of Configurational Comparative Methods. | BACKGROUND: The Department of Veterans Affairs (VA) cares for more patients with hepatitis C virus (HCV) than any other US health care system. We tracked the implementation strategies that VA sites used to implement highly effective new treatments for HCV with the aim of uncovering how combinations of implementation st... | ['Antiviral Agents', 'Critical Pathways', 'Hepatitis C', 'Humans', 'Medication Adherence', 'Program Evaluation', 'United States', 'United States Department of Veterans Affairs', 'Veterans Health Services'] | 32,187,105 | [['D27.505.954.122.388'], ['N04.590.233.624.625', 'N04.590.275'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.600.500', 'F01.145.488.887.500.600.500', 'N05.300.150.800.500.600.500'], ['E05.337.820', 'N04.761... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's disease. | BACKGROUND: Visual assessment rating scales for medial temporal lobe (MTL) atrophy have been used by neuroradiologists in clinical practice to aid the diagnosis of Alzheimer's disease (AD). Recently multivariate classification methods for magnetic resonance imaging (MRI) data have been suggested as alternative tools. I... | ['Aged', 'Alzheimer Disease', 'Cognition Disorders', 'Cohort Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Least-Squares Analysis', 'Likelihood Functions', 'Magnetic Resonance Imaging', 'Male', 'Multivariate Analysis', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Temporal Lobe'] | 21,811,624 | [['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['F03.615.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia. | Apolipoprotein E (apoE, protein; APOE, gene) is expressed as three isoforms in humans (E2, E3, E4). The APOE-epsilon4 allele is associated with a poor outcome in patients after head injury of which ischaemic brain damage is a contributor of mortality and morbidity. The aim of the study was to determine whether mice exp... | ['Alleles', 'Animals', 'Apolipoprotein E3', 'Apolipoprotein E4', 'Apolipoproteins E', 'Brain', 'Caudate Nucleus', 'Humans', 'Ischemic Attack, Transient', 'Mice', 'Mice, Transgenic', 'Neuroglia', 'Neurons', 'Promoter Regions, Genetic', 'Pyramidal Cells', 'Time Factors'] | 11,122,341 | [['G05.360.340.024.340.030'], ['B01.050'], ['D10.532.091.500.500', 'D12.776.070.400.500.500', 'D12.776.521.120.500.500'], ['D10.532.091.500.750', 'D12.776.070.400.500.750', 'D12.776.521.120.500.750'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['A08.186.211'], ['A08.186.211.200.885.287.249.487.5... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19. | Establishing signal transduction thresholds that regulate B lymphocyte responses to foreign Ags and tolerance to self Ags is critical for humoral immune responses. The effects of altered signaling thresholds in B lymphocytes were examined in CD19-deficient mice and transgenic mice that expressed human CD19 at varying d... | ['Animals', 'Antibody Formation', 'Antigens, CD19', 'B-Lymphocytes', 'Calcium', 'Genetic Complementation Test', 'Germinal Center', 'Humans', 'Immunoglobulin M', 'Lymphocyte Activation', 'Mice', 'Mice, Knockout', 'Signal Transduction'] | 9,144,478 | [['B01.050'], ['G12.450.050.370.250'], ['D23.050.301.264.035.119', 'D23.050.301.264.051.119', 'D23.050.301.500.600.200', 'D23.050.705.552.600.200', 'D23.101.100.110.119', 'D23.101.100.150.119'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distribution of the erm (B) gene, tetracycline resistance genes, and Tn1545-like transposons in macrolide- and lincosamide-resistant enterococci from pigs and humans. | The distribution of the erm (B) and the tetracycline resistance genes tet(K), tet(L), tet(M), tet(O), and tet(S) was investigated among macrolide- and lincosamide-resistant enterococci originating from humans, pigs, and pork carcasses. The presence of transposons of the Tn916/Tn1545 family was also traced in these isol... | ['Animals', 'DNA Transposable Elements', 'DNA, Bacterial', 'Drug Resistance, Bacterial', 'Enterococcus', 'Humans', 'Macrolides', 'Microbial Sensitivity Tests', 'Swine', 'Tetracycline Resistance'] | 15,650,380 | [['B01.050'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['D13.444.308.212'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['B03.353.750.250.250', 'B03.510.550.250.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.540.505', 'D02.54... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficiency of excitation energy trapping in the green photosynthetic bacterium Chlorobaculum tepidum. | During the millions of years of evolution, photosynthetic organisms have adapted to almost all terrestrial and aquatic habitats, although some environments are obviously more suitable for photosynthesis than others. Photosynthetic organisms living in low-light conditions require on the one hand a large light-harvesting... | ['Adaptation, Physiological', 'Bacteriochlorophyll A', 'Chlorobi', 'Energy Transfer', 'Fluorescence', 'Fluorometry', 'Light-Harvesting Protein Complexes', 'Photochemistry', 'Photosynthesis'] | 30,537,470 | [['G07.025', 'G16.012.500'], ['D12.776.752.249.500'], ['B03.250'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['E05.196.712.516.600'], ['D05.500.562.488.490', 'D08.811.600.710.490', 'D12.776.543.930.500.490', 'D12.776.765.199.750.750.490'], ['H01.181.529.711'], ['... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Monocytes treated with ciprofloxacin and oxyLDL express myristate, priming atherosclerosis. | Antibiotics are essential in many life-threatening diseases. On the other hand, improper use of antibiotics can be disastrous. Cell morphological changes were observed in the ciprofloxacin-treated cells starting at 48 hours. Changes in cell morphology were continuously observed up to 14 days, which showed gradual morph... | ['Atherosclerosis', 'Ciprofloxacin', 'Gene Expression Regulation', 'Humans', 'Lipoproteins, LDL', 'Monocytes', 'Myristic Acid', 'THP-1 Cells'] | 31,926,051 | [['C14.907.137.126.307'], ['D03.633.100.810.835.322.186'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532.515', 'D12.776.521.550'], ['A11.118.637.555.652', 'A11.148.580', 'A11.627.624', 'A11.733.547', 'A15.145.229.637.555.652', 'A15.378.316.580', 'A15.382.490.555.652', 'A15.382.670.547', 'A15.3... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Portacaval shunting attenuates portal hypertension and systemic hypotension in rat anaphylactic shock. | Anaphylactic shock in rats is characterized by antigen-induced hepatic venoconstriction and the resultant portal hypertension. We determined the role of portal hypertension in anaphylactic hypotension by using the side-to-side portacaval shunt- and sham-operated rats sensitized with ovalbumin (1 mg). We measured the me... | ['Anaphylaxis', 'Anesthesia', 'Animals', 'Antigens', 'Blood Pressure', 'Central Venous Pressure', 'Hypertension, Portal', 'Hypotension', 'Liver', 'Liver Circulation', 'Male', 'Ovalbumin', 'Portacaval Shunt, Surgical', 'Portal Pressure', 'Rats', 'Rats, Sprague-Dawley', 'Veins', 'Venous Pressure'] | 21,181,324 | [['C20.543.480.099'], ['E03.155'], ['B01.050'], ['D23.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.330.380.076.732.336'], ['C06.552.494'], ['C14.907.514'], ['A03.620'], ['G09.330.100.881.552'], ['D12.644.861.557', 'D12.776.034.614', 'D12.776.256.159.157.663', 'D12.776.290.663', 'D12.776.872.557'], ['E04.035... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Environmental effects on vibrational properties of carotenoids: experiments and calculations on peridinin. | Carotenoids are employed in light-harvesting complexes of dinoflagellates with the two-fold aim to extend the spectral range of the antenna and to protect it from radiation damage. We have studied the effect of the environment on the vibrational properties of the carotenoid peridinin in different solvents by means of v... | ['Acetonitriles', 'Carotenoids', 'Cyclohexanes', 'Hydrogen Bonding', 'Methanol', 'Molecular Dynamics Simulation', 'Quantum Theory', 'Spectrophotometry, Infrared', 'Spectrum Analysis, Raman'] | 21,946,923 | [['D02.626.080'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['D02.455.426.392.368.367'], ['G02.282'], ['D02.033.623'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['H01.671.579.800'], ['E05.196.712.726.676', 'E05.196.867.826.676'], ['E05.196.822.860... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Feeding dynamics, consumption rates and daily ration of wahoo Acanthocybium solandri in Indo-Pacific waters. | This study reports the diet composition of 363 wahoo Acanthocybium solandri captured from the Indo-Pacific. The study also provides the first estimates of consumption and daily ration for the species worldwide, which are important parameters for ecosystem models and may improve ecosystem-based fisheries management. Thi... | ['Animals', 'Diet', 'Ecosystem', 'Feeding Behavior', 'Fishes', 'Seasons'] | 28,217,894 | [['B01.050'], ['G07.203.650.240'], ['G16.500.275.157', 'N06.230.124'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.150.900.493'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Time trends in radiocaesium in the Japanese diet following nuclear weapons testing and Chernobyl: Implications for long term contamination post-Fukushima. | Estimation of time changes in radiocaesium in foodstuffs is key to predicting the long term impact of the Fukushima accident on the Japanese diet. We have modelled >4000 measurements, spanning 50 years, of 137Cs in foodstuffs and whole diet in Japan after nuclear weapons testing (NWT) and the Chernobyl accident. Broadl... | ['Cesium Radioisotopes', 'Chernobyl Nuclear Accident', 'Diet', 'Dietary Exposure', 'Fukushima Nuclear Accident', 'Humans', 'Japan', 'Nuclear Weapons', 'Radiation Monitoring', 'Time Factors'] | 28,605,864 | [['D01.268.549.125.500.300', 'D01.268.556.165.500.300', 'D01.496.180.300', 'D01.496.749.190', 'D01.552.528.160.500.300', 'D01.552.544.165.500.300'], ['K01.400.504.968.150', 'N06.850.135.848.500'], ['G07.203.650.240'], ['N06.850.460.350.040'], ['K01.400.504.984.186', 'N06.850.135.848.750'], ['B01.050.150.900.649.313.988... | ['Chemicals and Drugs [D]', 'Humanities [K]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Automatic detection of open and closed eye states in the electroencephalographic (EEG) record for background EEG interpretation by the trigger method. | Automatic detection of open and closed eye states in electroencephalographic (EEG) records was investigated in this study as a part of procedures for the precise interpretation of the background EEG to achieve a comprehensive automatic EEG interpretation system. The features of eye open and closure were extracted from ... | ['Adult', 'Aged', 'Automation', 'Brain', 'Electroencephalography', 'Humans', 'Image Processing, Computer-Assisted', 'Markov Chains', 'Middle Aged', 'Ocular Physiological Phenomena'] | 10,898,472 | [['M01.060.116'], ['M01.060.116.100'], ['J01.897.104'], ['A08.186.211'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E05.318.740.600.500', 'E05.318.740.996.500', 'G17.830.500', 'N05.715.360.750.625.500', 'N05.715.360.750.770.500', 'N06.850.520.830.600.500'... | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
Inclusion of cetaceans within the order Artiodactyla based on phylogenetic analysis of pancreatic ribonuclease genes. | Mammalian secretory ribonucleases (RNases 1) form a family of extensively studied homologous proteins that were already used for phylogenetic analyses at the protein sequence level previously. In this paper we report the determination of six ribonuclease gene sequences of Artiodactyla and two of Cetacea. These sequence... | ['Amino Acid Sequence', 'Animals', 'Artiodactyla', 'Base Sequence', 'Cetacea', 'DNA Primers', 'Molecular Sequence Data', 'Phylogeny', 'Ribonuclease, Pancreatic', 'Sequence Homology, Amino Acid', 'Sequence Homology, Nucleic Acid'] | 10,093,226 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.649.313.500'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.150.900.649.313.875'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D08.811.277... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Less is more: Negative income shock increases immediate preference in cross commodity discounting and food demand. | Negative income shock, or the rapid reduction in financial stability, has previously been shown to increase impulsive choice for money and demand for fast food. The interplay of these conditions for obesity is called reinforcer pathology. The present work examines the impact of negative income shock on monetary and fas... | ['Adult', 'Choice Behavior', 'Delay Discounting', 'Fast Foods', 'Female', 'Humans', 'Impulsive Behavior', 'Income', 'Male', 'Obesity', 'Stress, Psychological'] | 29,959,952 | [['M01.060.116'], ['F02.463.785.373.346'], ['F02.463.785.373.346.700'], ['G07.203.300.477', 'J02.500.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.527'], ['N01.824.417'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['F01.145.126.9... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Effects of 8h of eucapnic and poikilocapnic hypoxia on middle cerebral artery velocity and heart rate in humans. | This study examines the effects of prolonged hypoxia, with and without control of end-tidal CO2 partial pressure (PET,CO2), on the intensity-weighted mean velocity of blood flow in the middle cerebral artery (VIWM) and on heart rate (HR). Specifically, the time course of the responses, their reversibility with brief pe... | ['Blood Flow Velocity', 'Cerebral Arteries', 'Female', 'Heart Rate', 'Humans', 'Hypocapnia', 'Hypoxia', 'Male', 'Time Factors', 'Ultrasonography'] | 9,257,119 | [['E01.370.370.130', 'G09.330.380.630.080'], ['A07.015.114.228'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.614'], ['C23.888.852.079'], ['G01.910.857'], ['E01.370.350.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Center and other factor effects in recipients of living-donor kidney transplants. | UNLABELLED: 1.LIVING DONOR KIDNEY TRANSPLANTS: Using 1996-2001 UNOS Registry data, we assessed the joint influence of center, 19 pre- and 5 posttransplant factors on renal allograft function in 21,830 patients transplanted with living donor kidneys. During an initial risk period, 21,033 recipients were projected to kee... | ['Female', 'Graft Rejection', 'Graft Survival', 'Humans', 'Kidney Transplantation', 'Living Donors', 'Male', 'Time Factors', 'Treatment Outcome'] | 12,211,785 | [['G12.875.545.328'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.898.656'], ['G01.910.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Procedure- and Hospital-Level Variation of Deep Sternal Wound Infection From All-Japan Registry. | BACKGROUND: The outcome of cardiovascular surgery has been improving over time, but the treatment of postoperative complications such as deep sternal wound infection (DSWI) still needs critical attention. A nationwide surgical registry was analyzed for procedural details and hospital factors related to DSWI.METHODS: Th... | ['Aged', 'Aged, 80 and over', 'Aorta, Thoracic', 'Cardiac Surgical Procedures', 'Coronary Artery Bypass', 'Female', 'Heart Valves', 'Hospitals', 'Humans', 'Incidence', 'Japan', 'Male', 'Middle Aged', 'Registries', 'Sternum', 'Surgical Wound Infection'] | 31,336,072 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.015.114.056.372'], ['E04.100.376', 'E04.928.220'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['A07.541.510'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.50... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A novel concept in antiangiogenic and antitumoral therapy: multitarget destabilization of short-lived mRNAs by the zinc finger protein ZFP36L1. | Angiogenesis inhibitors have shown clinical benefits in patients with advanced cancer, but further therapeutic improvement is needed. We have previously shown that the zinc finger protein 36, C3H type-like 1 (ZFP36L1) enhances vascular endothelial growth factor (VEGF) mRNA decay through its interaction with AU-rich ele... | ['Adrenal Glands', 'Angiogenesis Inhibitors', 'Animals', 'Butyrate Response Factor 1', 'COS Cells', 'Carcinoma, Lewis Lung', 'Chlorocebus aethiops', 'Cytokines', 'Mice', 'Mice, Nude', 'Mice, SCID', 'Protein Structure, Tertiary', 'RNA Stability', 'RNA, Messenger', 'Recombinant Fusion Proteins', 'Vascular Endothelial Gro... | 20,802,528 | [['A06.300.071'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['D12.776.157.725.030', 'D12.776.260.114', 'D12.776.460.287', 'D12.776.664.962.061'], ['A11.251.210.172.500', 'A11.329.228.220'], ['C04.557.470.200.280', 'C04.619.230'], ['B01.050.150.900.649.313.988.400.112.19... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Risk factors associated with secondary enucleation after fractionated stereotactic radiotherapy in uveal melanoma. | PURPOSE: To evaluate risk factors for secondary enucleation after fractionated stereotactic radiotherapy (fSRT) in uveal melanoma.METHODS: In this retrospective study, clinical data of 118 consecutive patients who had initially been treated with fSRT between 1999 and 2009 were collected and analysed. The patients who h... | ['Adult', 'Aged', 'Aged, 80 and over', 'Chromosomes, Human, Pair 8', 'Dose Fractionation, Radiation', 'Eye Enucleation', 'Female', 'Follow-Up Studies', 'Humans', 'In Situ Hybridization, Fluorescence', 'Male', 'Melanoma', 'Middle Aged', 'Mitotic Index', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Radiosurgery', '... | 25,879,399 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A11.284.187.520.300.325.340', 'G05.360.162.520.300.325.340'], ['E02.815.639.200'], ['E04.540.429'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Paraplegia following removal of an epidural catheter]. | Acute paraplegia caused by an epidural hematoma developed in a patient following the removal of an epidural catheter. This catheter had been used for 3 days for postoperative pain relief with no apparent complications. Heparin (10,000 units/day) had been infused for thrombosis prophylaxis and was associated with a norm... | ['Analgesia, Epidural', 'Catheters, Indwelling', 'Hematoma, Epidural, Cranial', 'Humans', 'Male', 'Middle Aged', 'Pain, Postoperative', 'Paraplegia'] | 1,822,600 | [['E03.091.080'], ['E07.132.500'], ['C10.228.140.300.535.450.300', 'C10.900.300.837.300', 'C14.907.253.573.400.400', 'C23.550.414.838.349', 'C23.550.414.913.400', 'C26.915.300.490.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.767.700', 'C23.888.592.612.832'], ['C10.597.622.669',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Higher levels of hepatitis C virus RNA found in blood donors co-infected with HIV as compared to HCV mono-infected donors. | INTRODUCTION: Hepatitis C virus (HCV) infection and human immunodeficiency virus (HIV) infections are public health problems in sub-Saharan countries such as the Republic of Congo. HIV infection could impact the characteristics of HCV infection in co-infected people. We investigated HCV-HIV co-infection among blood don... | ['Adolescent', 'Adult', 'Blood Donors', 'Congo', 'Female', 'HIV Infections', 'Hepacivirus', 'Hepatitis C, Chronic', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'RNA, Viral', 'Transaminases', 'Viral Load', 'Young Adult'] | 25,116,677 | [['M01.060.057'], ['M01.060.116'], ['M01.898.313'], ['Z01.058.290.100.140'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Bacterial translocation in organ donors: clinical observations and potential risk factors. | Thirty-nine solid-organ donors were evaluated to determine the incidence of bacterial translocation to mesenteric lymph nodes. In addition, clinical variables from 59 local recipients of renal allografts from these donors were examined to assess whether translocation in donors was associated with increased morbidity in... | ['Bacterial Infections', 'Bacterial Translocation', 'Blood Transfusion', 'Cecum', 'Evaluation Studies as Topic', 'Follow-Up Studies', 'Graft Survival', 'Hospitalization', 'Humans', 'Hypotension', 'Ileum', 'Incidence', 'Kidney Transplantation', 'Length of Stay', 'Lymph Nodes', 'Mesentery', 'Postoperative Complications',... | 9,267,714 | [['C01.150.252'], ['G06.099.114'], ['E02.095.135'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['E05.337', 'N05.715.360.335'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G12.875.545.340'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.40... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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