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Shorter Mandibular Length is Associated with a Greater Fall in AHI with Weight Loss. | RATIONALE: Obesity is a major risk factor towards the development of obstructive sleep apnea, while significant weight loss (both conservatively managed and surgically assisted) has a variable effect upon its severity. Differences in the effect of weight loss on obstructive sleep apnea may be due to underlying craniofa... | ['Cephalometry', 'Female', 'Humans', 'Male', 'Mandible', 'Middle Aged', 'Obesity', 'Severity of Illness Index', 'Sleep Apnea, Obstructive', 'Weight Loss'] | 25,515,279 | [['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['M01.060.116.630'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['E05.318.308.980.43... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Suppression of rat hepatic cytochrome P450s by protein-calorie malnutrition: complete or partial restoration by cysteine or methionine supplementation. | Pharmacokinetic profiles of therapeutic agents are altered by protein-calorie malnutrition (PCM). The current study was designed to determine the expression of hepatic cytochrome P450s in rats after protein restriction and to investigate its molecular basis. Western blot analysis revealed that rats with protein restric... | ['Animals', 'Cysteine', 'Cytochrome P-450 CYP1A1', 'Cytochrome P-450 Enzyme System', 'Diuretics', 'Gene Expression', 'Liver', 'Male', 'Methionine', 'Protein-Energy Malnutrition', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Sulfanilamides'] | 10,562,428 | [['B01.050'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['D08.244.453.005.332', 'D08.244.453.100.500', 'D08.811.682.690.708.170.010.277', 'D08.811.682.690.708.170.020.500', 'D12.776.422.220.453.010.332', 'D12.776.422.220.453.100.500'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Transformation with the E1A + cHa-ras oncogenes enhances the trans-repressor function of the Elk-1 transcription factor]. | Rat embryo fibroblasts (REF) transformed with the complementing E1A and cHa-ras oncogenes show a down-regulation of the c-fos early response gene, which is transcribed with the participation of Elk-1. The role of Elk-1 was studied with constructs coding for the full-length factor or its N- or C-terminal fragment fused ... | ['Adenovirus E1A Proteins', 'Animals', 'Butyrates', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'DNA-Binding Proteins', 'Enzyme Inhibitors', 'Fibroblasts', 'Flavonoids', 'Genes, ras', 'Histone Deacetylases', 'Imidazoles', 'Mitogen-Activated Protein Kinases', 'Proto-Oncogene Proteins', 'Pyridines', 'Rats', 'Re... | 12,391,846 | [['D12.776.460.050.100', 'D12.776.624.664.520.045.050.100', 'D12.776.930.100', 'D12.776.964.700.045.050.100', 'D23.050.285.062.045', 'D23.050.327.062.045'], ['B01.050'], ['D02.241.081.114', 'D10.251.400.143'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['D12.776.260'], ['D27.505.519.389'], ['A11.329.228']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neuroleptics from the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole series. 3. Carboxamidoalkyl derivatives. | Substitution of position 2 of the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole nucleus with omega-carboxamidoalkyl substituents leads to compounds with exceedingly potent neuroleptic activity in in vitro and in vivo models. Although duration of activity is not as long as that of the analogous 4-hydroxy-4-... | ['Animals', 'Antipsychotic Agents', 'Carbolines', 'Hydrogen Bonding', 'Rats', 'Receptors, Dopamine', 'Structure-Activity Relationship'] | 2,876,105 | [['B01.050'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['D03.383.725.150', 'D03.633.100.473.155', 'D03.633.300.154'], ['G02.282'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.543.750.670.300.400', 'D12.776.543.750.695.150.400', 'D12.776.543.750.720.330.400'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort. | AIM: To examine the effect of the potential interaction between KIF1B variants (rs17401966 and rs3748578) and environmental factors on the risk of hepatocellular carcinoma (HCC) in a high-risk region in China.METHODS: Three hundred and six patients with HCC and 306 hospital-based control participants residing in the Sh... | ['Adult', 'Aged', 'Alcohol Drinking', 'Asian Continental Ancestry Group', 'Biomarkers, Tumor', 'Carcinoma, Hepatocellular', 'Case-Control Studies', 'Chi-Square Distribution', 'China', 'Female', 'Gene Frequency', 'Gene-Environment Interaction', 'Genetic Association Studies', 'Genetic Predisposition to Disease', 'Heteroz... | 27,122,668 | [['M01.060.116'], ['M01.060.116.100'], ['F01.145.317.269'], ['M01.686.508.200'], ['D23.101.140'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.7... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Evidence of synergistic relationships between HIV and Human Papillomavirus (HPV): systematic reviews and meta-analyses of longitudinal studies of HPV acquisition and clearance by HIV status, and of HIV acquisition by HPV status. | INTRODUCTION: Observational studies suggest HIV and human papillomavirus (HPV) infections may have multiple interactions. We reviewed the strength of the evidence for the influence of HIV on HPV acquisition and clearance, and the influence of HPV on HIV acquisition.METHODS: We performed meta-analytic systematic reviews... | ['Female', 'HIV Infections', 'Humans', 'Incidence', 'Longitudinal Studies', 'Male', 'Papillomavirus Infections', 'Papillomavirus Vaccines', 'Pregnancy', 'Vaccination'] | 29,873,885 | [['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['E05.318.372.500.750.500', 'N05... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Quantitation of carbohydrate monomers and dimers by liquid chromatography coupled with high-resolution mass spectrometry. | As remnants of plant wastes or plant secretions, carbohydrates are widely found in various environmental matrices. Carbohydrate-containing feedstocks represent important carbon sources for engineered bioproduction of commodity compounds. Routine monitoring and quantitation of heterogenous carbohydrate mixtures requires... | ['Carbohydrates', 'Chromatography, Liquid', 'Dimerization', 'Mass Spectrometry'] | 30,121,416 | [['D09'], ['E05.196.181.400'], ['G02.206', 'G03.230'], ['E05.196.566']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Targeting c-Met in melanoma: mechanism of resistance and efficacy of novel combinatorial inhibitor therapy. | Numerous tyrosine kinase inhibitors (TKIs) targeting c-Met are currently in clinical trials for several cancers. Their efficacy is limited due to the development of resistance. The present study aims to elucidate this mechanism of c-Met TKI resistance by investigating key mTOR and Wnt signaling proteins in melanoma cel... | ['Animals', 'Antineoplastic Combined Chemotherapy Protocols', 'Cell Line, Tumor', 'Drug Resistance, Neoplasm', 'Everolimus', 'Heterocyclic Compounds, 3-Ring', 'Heterografts', 'Human Growth Hormone', 'Humans', 'Indoles', 'Male', 'Melanoma', 'Mice, Inbred BALB C', 'Mice, Nude', 'Mutation', 'Phosphorylation', 'Piperazines... | 24,914,950 | [['B01.050'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['A11.251.210.190', 'A11.251.860.180'], ['G07.690.773.984.395'], ['D02.540.505.760.500'], ['D03.633.300'], ['A01.941.875'], ['D06.472.699.631.525.425.875', 'D12.644.548.691.525.425.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli. | Endogenous expression of human membrane type ganglioside sialidase (Neu3) was examined in various cell lines including NB-1, U87MG, SK-MEL-2, SK-N-MC, HepG2, Hep3B, Jurkat, HL-60, K562, ECV304, Hela and MCF-7. Expression was detected in the neuroblastoma cell lines NB-1 and SK-N-MC, and also in erythroleukemia K562 cel... | ['Amino Acid Sequence', 'Base Sequence', 'Cell Line', 'Escherichia coli', 'Gangliosides', 'Humans', 'Hydrogen-Ion Concentration', 'Hymecromone', 'Molecular Sequence Data', 'Neuraminidase', 'Recombinant Proteins'] | 15,179,041 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D09.400.410.420.025.475', 'D10.390.470.025.475', 'D10.570.877.360.025.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Riboflavin status among rural children in Southern Italy. | A sample of 107 boys aged 7-10 in a rural area of Southern Italy was studied for riboflavin deficiency and its association with milk consumption. The boys represented 74 per cent of the total male population of that age group in the study area. The nutritional status was assessed by means of anthropometric indicators, ... | ['Animals', 'Anthropometry', 'Child', 'Dairy Products', 'Diet', 'Erythrocytes', 'Glutathione Reductase', 'Humans', 'Italy', 'Male', 'Milk', 'Nutritional Physiological Phenomena', 'Riboflavin', 'Riboflavin Deficiency'] | 6,896,199 | [['B01.050'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['M01.060.406'], ['G07.203.300.350', 'J02.500.350'], ['G07.203.650.240'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D08.811.682.667.092'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['A12.200.455', 'A12.790', 'G07.203... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Orthostatic headache from spontaneous spinal cerebrospinal fluid leakage; diagnosed by heavily T2-weighted magnetic resonance myelography. | Orthostatic headache is derived from low cerebrospinal fluid (CSF) pressure as evidenced by cranial magnetic resonance myelography (MRM). This reports three cases of patients coming with orthostatic headache without previous obvious spine trauma. The first two cases had headache with radiating neck pain while the third... | ['Adult', 'Cerebrospinal Fluid', 'Female', 'Headache', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Myelography'] | 22,774,632 | [['M01.060.116'], ['A12.207.270.210'], ['C23.888.592.612.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E01.370.350.578.937.505', 'E01.370.350.700.560.505', 'E01.370.376.537.750.505', 'E05.629.937.505']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A compendium of familial relative risks of cancer among first degree relatives: a population-based study. | Familial clustering of cancer is expected to occur at practically all anatomical sites. However, few studies have had sufficient size to investigate different sites simultaneously and with adjustment for confounders. We evaluated familial clustering in the Netherlands Cohort Study in which 120,852 men and women, aged 5... | ['Cohort Studies', 'Female', 'Genetic Predisposition to Disease', 'Humans', 'Male', 'Neoplasms', 'Nuclear Family', 'Population Surveillance', 'Surveys and Questionnaires'] | 18,623,131 | [['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['F01.829.263.500', 'I01.880.853.150.500'], ['E05.318.308.980.438.700', 'N05.715.360.300.800.438.625', 'N06.850.520.308.980.438.700', 'N06.850... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Neurotrophins 3 and 4 differentially regulate NCAM, L1 and N-cadherin expression during peripheral nerve regeneration. | The addition of NT-3 (neurotrophin 3) or NT-4 to injured nerves improves their regeneration potential and may aid axon guidance. It is not well defined whether NTs (neurotrophins) influence other elements, such as the cell-adhesion molecules, which promote nerve guidance and regeneration. Using poly-3-hydroxybutyrate c... | ['Animals', 'Cadherins', 'Nerve Growth Factors', 'Nerve Regeneration', 'Neural Cell Adhesion Molecule L1', 'Neural Cell Adhesion Molecules', 'Neurotrophin 3', 'Rats', 'Rats, Sprague-Dawley', 'Sciatic Nerve', 'Sciatic Neuropathy'] | 17,640,175 | [['B01.050'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['D12.644.276.860', 'D12.776.467.860', 'D12.776.631.600', 'D23.529.850'], ['G11.561.585', 'G16.762.611'], ['D12.776.395.550.200.250.520.578', 'D12.776.543.550.200.250.520.578', 'D23.050.301.350.250.520.578'], ['D12.776.395.550.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of Myocardial (18)F-FDG Uptake by PET/CT in the Patients with Different Dialectically Classified Coronary Heart Diseases (CHD). | To quantify myocardial glucose metabolism by (18)F-FDG PET/CT in patients that have coronary heart disease (CHD) according to traditional Chinese medicine classification. Ninety patients with CHD were enrolled and were categorized into three groups. All patients underwent PET-CT examination for (18)F-FDG uptake quantif... | ['Adult', 'Coronary Artery Disease', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'International Classification of Diseases', 'Male', 'Middle Aged', 'Positron Emission Tomography Computed Tomography', 'Radiopharmaceuticals'] | 25,638,340 | [['M01.060.116'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.945.400'], ['M01.060.116.630'], ['E01.370.350.350.800.700.500', 'E01.370.350.350.810.645', 'E01.370.350.567.500', 'E01.370.350.600.350.700.810.490'... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Metabolic syndrome and endothelin-1 mediated vasoconstrictor tone in overweight/obese adults. | OBJECTIVE: To determine whether endothelin (ET)-1 vasoconstrictor tone is greater in overweight and obese adults with the metabolic syndrome (MetS).MATERIALS/METHODS: Forty overweight/obese middle-aged and older adults (age: 43-71 years; BMI: 25.1-36.9 kg/m²) were studied: 20 without MetS (13 M/7 F) and 20 with MetS (1... | ['Adult', 'Aged', 'Blood Vessels', 'Body Mass Index', 'Cross-Sectional Studies', 'Endothelin A Receptor Antagonists', 'Endothelin B Receptor Antagonists', 'Endothelin-1', 'Female', 'Forearm', 'Humans', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Obesity', 'Overweight', 'Prehypertension', 'Receptor, Endothelin A', 'Re... | 24,856,242 | [['M01.060.116'], ['M01.060.116.100'], ['A07.015'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D27.505.519.364.500'], ['D27.505.519.364.750'], ['D12.644.276.400.225', 'D12.776.467.400.225'... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
ASK1 promotes the contact hypersensitivity response through IL-17 production. | Contact hypersensitivity (CHS) is a form of delayed-type hypersensitivity triggered by the response to reactive haptens (sensitization) and subsequent challenge (elicitation). Here, we show that ASK1 promotes CHS and that suppression of ASK1 during the elicitation phase is sufficient to attenuate CHS. ASK1 knockout (KO... | ['Animals', 'CD4-Positive T-Lymphocytes', 'Dermatitis, Contact', 'Dinitrofluorobenzene', 'Disease Models, Animal', 'HEK293 Cells', 'Humans', 'Interferon-gamma', 'Interleukin-17', 'MAP Kinase Kinase Kinase 5', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'p38 Mitogen-Activated Protein Kinases'] | 24,736,726 | [['B01.050'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['C17.800.174.255', 'C17.800.815.255'], ['D02.455.426.559.389.565.280', 'D02.640.529.240.280'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.31... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative sensitivity of Histoplasma capsulatum conidiospores and blastospores to oxidative antifungal systems. | The comparative sensitivity of blastospores and conidiospores of Histoplasma capsulatum to hydrogen peroxide, to hydrogen peroxide and halides, and to a combination of hydrogen peroxide and halide with the enzyme myeloperoxidase was studied. Blastospores of different strains of H. capsulatum varied in their sensitivity... | ['Animals', 'Catalase', 'Chlorides', 'Cytoplasmic Granules', 'Guinea Pigs', 'Histoplasma', 'Hydrogen Peroxide', 'Iodides', 'Peroxidase', 'Peroxidases', 'Spores, Fungal'] | 6,260,684 | [['B01.050'], ['D08.811.682.732.332'], ['D01.210.450.150', 'D01.248.497.158.215'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['B01.050.150.900.649.313.992.550'], ['B01.300.381.440'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['D01.248.497.158... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reconstruction of bone defect using the bone transport technique for a case of osteosarcoma of the femur. | There are few reports on skeletal reconstruction using the bone transport technique to repair bone defects caused by resections of tumors associated with osteosarcoma. We attempted to reconstruct a 23 cm bone defect after resection of an osteosarcoma of the left femur, and succeeded in gaining 17 cm by bone transport. ... | ['Bone Regeneration', 'Bony Callus', 'Child', 'Female', 'Femoral Neoplasms', 'Humans', 'Ilizarov Technique', 'Osteosarcoma', 'Radiography'] | 9,548,997 | [['G11.427.213.140', 'G16.762.150.150'], ['A10.165.265.200'], ['M01.060.406'], ['C04.588.149.276', 'C05.116.231.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.555.120.380', 'E04.555.300.380'], ['C04.557.450.565.575.650', 'C04.557.450.795.620'], ['E01.370.350.700']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The scientific claims of British child guidance, 1918-45. | This article examines the British child guidance movement's claim to scientific status and what it sought to gain by the wider acceptance of such a claim. The period covered is from the movement's origins in the 1920s to the end of the Second World War, by which point it had been incorporated into the welfare state. Th... | ['Child', 'Child Guidance', 'Child Psychiatry', 'Child, Preschool', 'History, 20th Century', 'Humans', 'Mental Health', 'United Kingdom'] | 20,027,910 | [['M01.060.406'], ['F02.784.629.272', 'F04.408.192'], ['F04.096.544.193', 'H02.403.690.130'], ['M01.060.406.448'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.418', 'N01.400.500'], ['Z01.542.363']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Imaging predictors of clinical deterioration in cerebral venous thrombosis. | Cerebral venous thrombosis (CVT) is a rare stroke subtype with a highly variable clinical course. There is limited information on clinical deterioration in these patients, and imaging predictors of deterioration have not been studied adequately. Therefore, we aimed to investigate the radiological predictors of clinical... | ['Adult', 'Aged', 'Anticoagulants', 'Brain Edema', 'Cerebral Infarction', 'Demography', 'Diffusion Magnetic Resonance Imaging', 'Disease Progression', 'Female', 'Humans', 'Intracranial Hemorrhages', 'Intracranial Thrombosis', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neuroimaging', 'Predictive Value of Test... | 22,796,274 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.502.119'], ['C10.228.140.187'], ['C10.228.140.300.150.477.200', 'C10.228.140.300.775.200.200', 'C14.907.253.092.477.200', 'C14.907.253.855.200.200', 'C23.550.513.355.250.200', 'C23.550.717.489.250.200'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['E01.370.350.825.50... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma. | Asthma is a chronic inflammatory disease. Although many patients with asthma develop type-2 dominated eosinophilic inflammation, a number of individuals develop paucigranulocytic asthma, which occurs in the absence of eosinophilia or neutrophilia. The aetiology of paucigranulocytic asthma is unknown. However, both resp... | ['Agranulocytosis', 'Animals', 'Asthma', 'Genetic Predisposition to Disease', 'HMGB1 Protein', 'Mice', 'Murine pneumonia virus', 'Receptor for Advanced Glycation End Products', 'Viral Load'] | 28,099,113 | [['C15.378.553.546.184'], ['B01.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C23.550.291.687.500', 'G05.380.355'], ['D12.776.260.356.300', 'D12.776.660.235.400.600.300', 'D12.776.664.235.400.600.300'], ['B01.050.150.900.649.313.992.635.505.500'], ['B04.820.480.937.600.670.600.550']... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
25-hydroxyvitamin D, parathyroid hormone, and functional recovery after hip fracture in elderly patients. | There is increasing interest in the effects of vitamin D and parathyroid hormone (PTH) on extraskeletal tissues, including the muscle. These effects may explain impairment in functional ability found in vitamin D-deficient subjects. Our aim was to investigate the roles of vitamin D and PTH in affecting the ability to p... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Bone Density', 'Female', 'Hip Fractures', 'Humans', 'Linear Models', 'Male', 'Parathyroid Hormone', 'Prognosis', 'Recovery of Function', 'Statistics, Nonparametric', 'Vitamin D', 'Vitamin D Deficiency'] | 16,369,897 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G11.427.100'], ['C26.404.061.425', 'C26.531.750', 'C26.558.276.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Comparative analysis on the biological basis of blood stasis syndrome induced by qi-stagnation and qi-deficiency in patients with unstable angina pectoris]. | OBJECTIVE: To comparatively analyse the objective characteristics of different syndrome types of qi-disturbance-induced blood stasis syndrome (QDBS) in the pathogenetic evolution of unstable angina coronary heart disease (UA-CHD).METHODS: Seventy-eight patients with UA-CHD of QDBS were differentiated into 2 groups: 55 ... | ['Adult', 'Angina, Unstable', 'Coronary Disease', 'Diagnosis, Differential', 'Female', 'Humans', 'Male', 'Medicine, Chinese Traditional', 'Qi'] | 20,669,667 | [['M01.060.116'], ['C14.280.647.187.150', 'C14.907.585.187.150', 'C23.888.592.612.233.500.150'], ['C14.280.647.250', 'C14.907.585.250'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.488.585.520', 'I01.076.201.450.654.558.520'], ['I01.076.201.450.654.558.520.300', 'K01.752.730']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Polypharmacy and Crohn's disease. | BACKGROUND: Polypharmacy has not been defined for Crohn's disease.AIMS: To determine the prevalence of polypharmacy, factors associated with polypharmacy, and consequences of polypharmacy in a Crohn's disease population.METHODS: A review of 291 Crohn's disease patients was performed. Polypharmacy was defined as either ... | ['Adult', 'Age Factors', 'Aminosalicylic Acids', 'Anti-Inflammatory Agents, Non-Steroidal', 'Crohn Disease', 'Female', 'Humans', 'Male', 'Middle Aged', 'Polypharmacy', 'Quality of Life', 'Retrospective Studies', 'Risk Factors', 'Severity of Illness Index', 'Sex Factors'] | 15,882,241 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['D02.241.223.100.300.595.100', 'D02.241.511.390.595.100', 'D02.455.426.559.389.127.281.595.100', 'D02.455.426.559.389.657.410.595.100'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['C06.405.205.731.500', 'C06.405.469.432.... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease. | Apolipoprotein E (ApoE) epsilon4 allele, a risk factor for the development of Alzheimer's disease (AD), is associated with increased amyloid deposition. We examined cerebral cortex in 68 AD cases using antibodies to beta-amyloid (Abeta) peptides of different length (Abeta1-40 and Abeta1-42) and found that the increased... | ['Alzheimer Disease', 'Amyloid beta-Peptides', 'Apolipoproteins E', 'Carboxypeptidases', 'Cerebral Cortex', 'Genotype', 'Humans', 'Immunohistochemistry'] | 8,602,762 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['D08.811.277.656.350.245'], ['A08.186.211.200.885.287.500'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of endoscopic ultrasonography as an indicator for surgical treatment of gastric cancer. | BACKGROUND AND METHODS: Clinicopathological analysis of 346 patients with gastric cancer was made retrospectively and new criteria for the indication of a limited operation using endoscopic ultrasonography (EUS) was developed. Suggested new criteria for selecting gastric cancer patients for the limited operation were: ... | ['Adult', 'Aged', 'Endoscopy, Gastrointestinal', 'Endosonography', 'Evaluation Studies as Topic', 'Female', 'Gastrectomy', 'Humans', 'Male', 'Middle Aged', 'Pilot Projects', 'Predictive Value of Tests', 'Prognosis', 'Prospective Studies', 'Retrospective Studies', 'Stomach Neoplasms', 'Survival Rate'] | 10,385,062 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['E01.370.350.850.280'], ['E05.337', 'N05.715.360.335'], ['E04.210.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.750', 'E05.337.737', 'N05.715... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Utility of detailed preoperative cardiac testing and incidence of post-thoracotomy myocardial infarction. | OBJECTIVE: Recent literature has questioned the efficacy of routine detailed preoperative cardiac ischemia testing and preoperative cardiac intervention before noncardiac surgical procedures.METHODS: We performed a retrospective review of patients undergoing thoracotomy (n = 294) between January of 1999 and January of ... | ['Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Angioplasty, Balloon, Coronary', 'Cardiac Catheterization', 'Cohort Studies', 'Coronary Angiography', 'Echocardiography, Stress', 'Female', 'Follow-Up Studies', 'Heart Function Tests', 'Humans', 'Incidence', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Multivaria... | 18,329,488 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'],... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Hyperfractionated high-dose proton beam radiotherapy for clival chordomas after surgical removal. | OBJECTIVE: To evaluate the hyperfractionated high-dose proton beam therapy (PBT) for patients with clival chordomas.METHODS: Records for 19 patients with pathologically verified clival chordomas treated with surgery followed by hyperfractionated PBT were retrospectively reviewed. The first 9 consecutive patients were t... | ['Adolescent', 'Adult', 'Aged', 'Brain Neoplasms', 'Chordoma', 'Dose Fractionation, Radiation', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Proton Therapy', 'Retrospective Studies', 'Survival Analysis', 'Treatment Outcome', 'Young Adult'] | 27,097,665 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.557.465.220'], ['E02.815.639.200'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Analysis of the obstetrical situation in swine from the clinical point of view]. | In a study including 477 parturitions in sows the obstetrical situation of this species is analyzed from the clinical point of view. Obstetrical interventions before consulting the veterinary clinics led to partly severe lesions of soft tissues of the genital tract in 35.5% of all primiparous and in 12.6% of all plurip... | ['Animals', 'Animals, Newborn', 'Body Temperature', 'Cesarean Section', 'Creatine Kinase', 'Dystocia', 'Female', 'Genitalia, Female', 'Maternal Age', 'Obstetric Labor Complications', 'Parity', 'Pregnancy', 'Swine', 'Swine Diseases', 'Wounds and Injuries'] | 8,346,523 | [['B01.050'], ['B01.050.050.282'], ['E01.370.600.875.374', 'G07.110'], ['E04.520.252.500'], ['D08.811.913.696.640.150'], ['C13.703.420.288'], ['A05.360.319'], ['G08.686.560', 'N05.715.350.075.550', 'N06.850.490.250.550'], ['C13.703.420'], ['G08.686.677', 'G08.686.784.769.472', 'N06.850.490.812.600'], ['G08.686.784.769'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. | To examine the genetic basis of age-related macular degeneration (ARMD), a degenerative disease of the retinal pigment epithelium and neurosensory retina, we conducted a genomewide scan in 34 extended families (297 individuals, 349 sib pairs) ascertained through index cases with neovascular disease or geographic atroph... | ['Aged', 'Aging', 'Chromosome Mapping', 'Female', 'Genetic Markers', 'Genetic Predisposition to Disease', 'Genome, Human', 'Humans', 'Lod Score', 'Macular Degeneration', 'Male', 'Middle Aged', 'Phenotype', 'Siblings'] | 14,691,731 | [['M01.060.116.100'], ['G07.345.124'], ['E05.393.183'], ['D23.101.387', 'G05.695.450'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.348.750'], ['C11.768.585.439'], ['M01.060.116.630'], ['G05.695'], ['F01.829.263.500.490', 'I01.880.853.150.500.505',... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Alcohol intake and risk of acute coronary syndrome and mortality in men and women with and without hypertension. | Although a light to moderate alcohol intake is associated with a lower risk of acute coronary syndrome (ACS), alcohol is also associated with risk of hypertension, which in turn is a strong risk factor of ACS. We examined whether middle-aged men and women with hypertension also benefit from a light to moderate alcohol ... | ['Acute Coronary Syndrome', 'Alcohol Drinking', 'Blood Pressure Determination', 'Cohort Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Proportional Hazards Models', 'Prospective Studies', 'Risk Factors', 'Surveys and Questionnaires'] | 21,424,217 | [['C14.280.647.124', 'C14.907.585.124'], ['F01.145.317.269'], ['E01.370.370.140', 'E01.370.600.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Visual aftereffects for walking actions reveal underlying neural mechanisms for action recognition. | The results of this study illustrate a new high-level visual aftereffect: Observing actors walking forward, without horizontal translation, makes subsequent actors appear to walk backward, and the opposite effect is obtained after observing backward walking. We used this aftereffect, which cannot be explained by simple... | ['Adaptation, Physiological', 'Adult', 'Female', 'Figural Aftereffect', 'Humans', 'Male', 'Motion Perception', 'Photic Stimulation', 'Psychophysics', 'Recognition, Psychology', 'Social Perception', 'Students', 'Walking', 'Young Adult'] | 21,164,175 | [['G07.025', 'G16.012.500'], ['M01.060.116'], ['F02.463.593.932.401', 'G14.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.932.567'], ['E05.723.729'], ['E01.370.685', 'F04.096.753'], ['F02.463.425.540.706'], ['F02.463.593.752'], ['M01.848'], ['G11.427.410.568.900', 'G11.427.410.698.277.937', 'I03.... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
[Results of radiotherapy with cobalt 60 beads compared to surgery in 725 uterine neoplasms]. | From 1958 to 1970, in 435 cases (60%) out of 725 carcinomas of the uterus sole radiation therapy by cobalt-60 beads was performed; in 288 cases (39.7%) surgery was done (combined with tele-cobalt-irradiation in almost all cases, 5000 to 6000 rd TD). Two cases (0.3%) received no treatment. The unfavorable selection of t... | ['Adult', 'Aged', 'Cobalt Radioisotopes', 'Female', 'Humans', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Radiation Injuries', 'Uterine Neoplasms', 'Vesicovaginal Fistula'] | 1,209,670 | [['M01.060.116'], ['M01.060.116.100'], ['D01.268.556.185.500.354', 'D01.268.956.155.500.354', 'D01.496.239.354', 'D01.496.749.256', 'D01.552.544.185.500.354'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.655', 'C23.550.727.655'], ['C26.733', 'G01.750.748.500', 'N06.850.460.350.850.50... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Preventing postoperative haematomas in microvascular reconstruction of the head and neck: lessons learnt from 126 consecutive cases. | BACKGROUND: Free tissue transfer has become a safe and reliable means for repairing soft tissue and bony defects of the head and neck. Although operative success has reached 98%, the incidence of significant postoperative complications is also relatively high (32%). One common and significant complication is haematoma ... | ['Female', 'Head', 'Hematoma', 'Humans', 'Male', 'Microsurgery', 'Middle Aged', 'Neck', 'Reconstructive Surgical Procedures', 'Retrospective Studies', 'Risk Factors', 'Surgical Flaps', 'Treatment Outcome'] | 18,380,738 | [['A01.456'], ['C23.550.414.838'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.494', 'E05.591.580'], ['M01.060.116.630'], ['A01.598'], ['E04.680'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.... | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Associations between alcohol consumption and sleep-disordered breathing among Japanese women. | BACKGROUND: The associations between alcohol consumption and sleep-disordered breathing in women are uncertain.METHODS: We conducted a cross-sectional study of 3113 women aged 30-69 years. The 3% oxygen desaturation index (3% ODI), based on overnight pulse oximetry findings, was selected as an indicator of sleep-disord... | ['Adult', 'Aged', 'Alcohol Drinking', 'Asian Continental Ancestry Group', 'Body Mass Index', 'Cross-Sectional Studies', 'Female', 'Humans', 'Middle Aged', 'Odds Ratio', 'Oximetry', 'Sleep Apnea Syndromes'] | 21,277,183 | [['M01.060.116'], ['M01.060.116.100'], ['F01.145.317.269'], ['M01.686.508.200'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A de novo unbalanced translocation leading to partial monosomy 9p23-pter and partial trisomy 15q25.3-qter associated with 46,XY complete gonadal dysgenesis, tall stature and mental retardation. | Syndromic forms of disorders of sex development constitute a challenge for clinical and molecular investigations. We report on a 12-year-old girl presenting with lack of pubertal development, tall stature and moderate mental retardation. Conventional karyotyping at the age of 3 years revealed a male karyotype (46,XY). ... | ['Body Height', 'Child', 'Child, Preschool', 'Chromosomes, Human, Pair 15', 'Chromosomes, Human, Pair 9', 'Female', 'Gonadal Dysgenesis', 'Gonadal Dysgenesis, 46,XY', 'Humans', 'In Situ Hybridization, Fluorescence', 'Intellectual Disability', 'Karyotyping', 'Male', 'Translocation, Genetic'] | 20,671,549 | [['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['M01.060.406'], ['M01.060.406.448'], ['A11.284.187.520.300.370.385', 'G05.360.162.520.300.370.385'], ['A11.284.187.520.300.325.345', 'G05.360.162.520.300.325.345'], ['C12.706.316.309', 'C13.351.875.253.309', 'C16.131... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The diagnosis of problems after meniscectomy. | The causes of persistent symptoms after meniscectomy have been assessed clinically, radiologically and arthroscopically in 174 knees. The commonest finding was early degenerative arthritis (chondromalacia) of the femoral condyle (40 per cent). Retained fragments of meniscus were less common than expected (13 per cent),... | ['Adult', 'Arthritis', 'Endoscopy', 'Humans', 'Joint Diseases', 'Knee Injuries', 'Knee Joint', 'Ligaments, Articular', 'Middle Aged', 'Postoperative Complications', 'Radiography', 'Tissue Adhesions'] | 1,158,945 | [['M01.060.116'], ['C05.550.114'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550'], ['C26.558.554'], ['A02.835.583.475'], ['A02.513.514', 'A02.835.583.512', 'A10.165.669.514'], ['M01.060.116.630'], ['C23.550.767'], ['E01.370.350.700'], ['C23.550.355.274.840']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice. | OBJECTIVE: To determine whether functional suppression of the catalytic domain of activation-induced cytidine deaminase (AID) can suppress the hyperreactive germinal center (GC) responses in BXD2 mice.METHODS: We generated transgenic BXD2 mice expressing a dominant-negative (DN) form of Aicda at the somatic hypermutati... | ['Animals', 'Apoptosis', 'Autoantibodies', 'B-Lymphocytes', 'Catalytic Domain', 'Cytidine Deaminase', 'DNA Damage', 'Enzyme-Linked Immunosorbent Assay', 'Flow Cytometry', 'Germinal Center', 'Immunohistochemistry', 'Mice', 'Mice, Transgenic', 'Reverse Transcriptase Polymerase Chain Reaction'] | 21,305,519 | [['B01.050'], ['G04.146.954.035'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['D08.811... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma. | Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, especially in patients not amenable for curative treatments. The multi-kinase inhibitor sorafenib represents the first-line treatment option for advanced HCC; nevertheless, its effecti... | ['AC133 Antigen', 'Animals', 'Antineoplastic Agents', 'Carcinoma, Hepatocellular', 'Cell Cycle Checkpoints', 'Cell Line, Tumor', 'Cell Movement', 'DNA (Cytosine-5-)-Methyltransferases', 'Disease Models, Animal', 'Drug Resistance, Neoplasm', 'Epigenesis, Genetic', 'Humans', 'Liver Neoplasms', 'Mice', 'MicroRNAs', 'PTEN ... | 29,305,580 | [['D12.776.395.550.007', 'D12.776.543.550.023'], ['B01.050'], ['D27.505.954.248'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.144.109'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['D08.811.913.555.500.350.100.500'], ['C22.232', 'E05.598.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Parameter estimation with a novel gradient-based optimization method for biological lattice-gas cellular automaton models. | Lattice-gas cellular automata (LGCAs) can serve as stochastic mathematical models for collective behavior (e.g. pattern formation) emerging in populations of interacting cells. In this paper, a two-phase optimization algorithm for global parameter estimation in LGCA models is presented. In the first phase, local minima... | ['Algorithms', 'Cells', 'Computer Simulation', 'Models, Biological', 'Neovascularization, Physiologic'] | 20,886,214 | [['G17.035', 'L01.224.050'], ['A11'], ['L01.224.160'], ['E05.599.395'], ['G09.330.630']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Hyperbaric medicine: state of the art, 1979. | An attempt has been made to determine the clinical usage of hyperbaric oxygen therapy at 83 North American hyperbaric treatment centers from 1971 to 1978. Questions were asked about the conditions or diseases treated, yearly case load for each condition, location of functional hyperbaric chambers, types of chambers use... | ['Brain Ischemia', 'Burns', 'Carbon Monoxide Poisoning', 'Craniocerebral Trauma', 'Decompression Sickness', 'Embolism, Air', 'Gas Gangrene', 'Humans', 'Hyperbaric Oxygenation', 'Osteomyelitis', 'Osteoradionecrosis'] | 7,125,385 | [['C10.228.140.300.150', 'C14.907.253.092'], ['C26.200'], ['C25.723.455.245'], ['C10.900.300', 'C26.915.300'], ['C26.120.248'], ['C14.907.355.350.254'], ['C01.150.252.410.222.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.880.690.490'], ['C01.160.495', 'C05.116.165.495'], ['C26.733.579', 'G01.750.748.500... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mel-18 negatively regulates stem cell-like properties through downregulation of miR-21 in gastric cancer. | Mel-18, a polycomb group protein, has been reported to act as a tumor suppressor and be down-regulated in several human cancers including gastric cancer. It was also found that Mel-18 negatively regulates self-renewal of hematopoietic stem cells and breast cancer stem cells (CSCs). This study aimed to clarify its role ... | ['Animals', 'Apoptosis', 'Biomarkers, Tumor', 'Cell Movement', 'Cell Proliferation', 'Follow-Up Studies', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Mice', 'Mice, SCID', 'MicroRNAs', 'Neoplastic Stem Cells', 'Polycomb Repressive Complex 1', 'Prognosis', 'Stomach Neoplasms', 'Survival Rate', 'Tumor Cells, Cult... | 27,542,229 | [['B01.050'], ['G04.146.954.035'], ['D23.101.140'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Counselling in primary care: a randomised controlled trial. | A randomised controlled trial of the effectiveness of counselling (In-House Counselled (IHC) group) compared to routine advice from General Practitioners (Routine Treatment (RT) group) was conducted with three practices and a total of 188 patients in East Sussex. Changes in interpersonal problems using the 32 item Inve... | ['Counseling', 'Family Practice', 'Humans', 'Longitudinal Studies', 'Mental Disorders', 'Mental Health Services', 'Psychological Tests', 'Referral and Consultation', 'Stress, Psychological', 'Treatment Outcome'] | 9,423,503 | [['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['F03'], ['F04.408', 'N02.421.461'], ['F04.711'], ['N04.452.758.849'], ['F01.145.126.990... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Periodontitis is associated with an increased risk for proximal colorectal neoplasms. | Interval colorectal cancers detected after colonoscopy are known to be highly associated with proximal colorectal neoplasms (CRNs). This cross-sectional study investigated whether periodontitis could be a risk factor for proximal CRNs in healthy individuals. A total of 2504 subjects who received a colonoscopy and denta... | ['Adult', 'Colorectal Neoplasms', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Odds Ratio', 'Oral Health', 'Periodontitis', 'Prevalence', 'Republic of Korea', 'Retrospective Studies', 'Risk Factors', 'Smoking'] | 31,101,852 | [['M01.060.116'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA. | Pregnancy-associated malaria (PAM) is characterized by the placental sequestration of Plasmodium falciparum-infected erythrocytes (IEs) with the ability to bind to chondroitin sulfate A (CSA). VAR2CSA is a leading candidate for a pregnancy malaria vaccine, but its large size ( approximately 350 kDa) and extensive polym... | ['Amino Acid Sequence', 'Animals', 'Antibodies, Protozoan', 'Antigens, Protozoan', 'Cell Line', 'Cross Reactions', 'Epitopes', 'Female', 'Humans', 'Malaria Vaccines', 'Malaria, Falciparum', 'Molecular Sequence Data', 'Plasmodium falciparum', 'Polymorphism, Genetic', 'Pregnancy', 'Rabbits', 'Recombinant Proteins'] | 18,250,177 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['D23.050.293'], ['A11.251.210'], ['G12.122.281'], ['D23.050.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D20.215.894.582.500'], ['C01.610.752.530.650', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Comparison of neutralizing antibody and cell-mediated immune responses to pandemic H1N1 2009 influenza virus before and after H1N1 2009 influenza vaccination of elderly subjects and healthcare workers. | BACKGROUND: The recent H1N1 pandemic virus that emerged in 2009 resulted in high morbidity rates mainly in younger individuals, albeit with relatively low mortality. We investigated both humoral and cellular immune responses against the pandemic H1N1 2009 virus before and after immunization with inactivated H1N1 2009 v... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Antibodies, Neutralizing', 'Antibodies, Viral', 'Female', 'Humans', 'Immunity, Cellular', 'Influenza A Virus, H1N1 Subtype', 'Influenza Vaccines', 'Influenza, Human', 'Male', 'Middle Aged', 'Pandemics', 'Sex Factors', 'T-Lymphocytes', 'Young Adult'] | 22,704,721 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['B01.050.150.900.649.313.... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Biochemical and antiarrhythmic effects of three calcium channel antagonists in ischemic canine hearts. | The cardioprotective and antiarrhythmic effects of diltiazem, nilvadipine, and verapamil were evaluated in 33 dogs. The left anterior descending coronary artery (LAD) was occluded for two hours, 25 minutes after saline administration (controls); ten minutes after diltiazem (0.25 mg/kg); 15 minutes after nilvadipine (1 ... | ['Acetylglucosaminidase', 'Animals', 'Anti-Arrhythmia Agents', 'Blood Pressure', 'Calcium Channel Blockers', 'Coronary Disease', 'Diltiazem', 'Dogs', 'Female', 'Glucuronidase', 'Lysosomes', 'Male', 'Mitochondria, Heart', 'Myocardium', 'Nifedipine', 'Oxygen Consumption', 'Verapamil'] | 2,776,164 | [['D08.811.277.450.483.180.500'], ['B01.050'], ['D27.505.954.411.097'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['C14.280.647.250', 'C14.907.585.250'], ['D03.633.100.079.150'], ['B01.050.150.900.649.313.750.250.216.200'], ['D08.811.277.450.426']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolation of retro-transcribed RNA from in vitro Mycosphaerella fijiensis-infected banana leaves. | High polyphenol and polysaccharide levels in plant tissues such as banana fruit and leaves constitute a significant challenge to the extraction of sufficient amounts of high-quality RNA required for cDNA library synthesis and molecular analysis. To determine their comparative effectiveness at eliminating polyphenols, p... | ['Ascomycota', 'Flavonoids', 'Musa', 'Phenols', 'Plant Leaves', 'Polymerase Chain Reaction', 'Polyphenols', 'Polysaccharides', 'RNA, Plant'] | 20,677,135 | [['B01.300.107'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['B01.650.940.800.575.912.250.618.937.555.500'], ['D02.455.426.559.389.657'], ['A18.024.812'], ['E05.393.620.500'], ['D02.455.426.559.389.657.715', 'D03.633.100.150.266.450.260.777'], ['D09.698'], ['D13.444.735.635']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differentiation by imaging of superior segmental optic hypoplasia and normal-tension glaucoma with inferior visual field defects only. | PURPOSE: To differentiate superior segmental optic hypoplasia (SSOH) from normal-tension glaucoma (NTG) with inferior visual field defects only.METHODS: Eighteen eyes with SSOH (SSOH group) and 19 eyes with NTG (NTG group) were examined by optical coherence tomography (OCT), Heidelberg retina tomography (Heidelberg Ret... | ['Adult', 'Female', 'Humans', 'Intraocular Pressure', 'Low Tension Glaucoma', 'Male', 'Middle Aged', 'Nerve Fibers', 'Optic Disk', 'Optic Nerve Diseases', 'ROC Curve', 'Reproducibility of Results', 'Retrospective Studies', 'Scotoma', 'Tomography, Optical Coherence', 'Visual Field Tests', 'Visual Fields'] | 23,093,312 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['C11.525.381.703', 'C11.640.225'], ['M01.060.116.630'], ['A08.675.542', 'A11.671.501'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['C10.292.700', 'C11.640'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.680', '... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The Power of Interstimulus Interval for the Assessment of Temporal Processing in Rodents. | Temporal processing deficits have been implicated as a potential elemental dimension of higher-level cognitive processes, commonly observed in neurocognitive disorders. Despite the popularization of prepulse inhibition (PPI) in recent years, many current protocols promote using a percent of control measure, thereby pre... | ['Acoustic Stimulation', 'Age Factors', 'Animals', 'Female', 'Male', 'Mental Processes', 'Prepulse Inhibition', 'Rats'] | 31,058,895 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['F02.463'], ['G11.561.794.500'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The colour of the optic disc variation with location of illumination. | The variation of the colour of the optic disc was examined with a slit lamp and contact lens in 200 normal subjects simply by moving the image of the slit across the optic disc. This event was photographed in 15 subjects and colour densitometry was performed. The temporal part of the pale central excavation changes col... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Color', 'Colorimetry', 'Humans', 'Lighting', 'Middle Aged', 'Optic Disk', 'Photography'] | 7,331,771 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['G01.590.540.199'], ['E05.196.922.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.230.150.410'], ['M01.060.116.630'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['E01.370.350.600', 'E05.712']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Saponin-rich fraction from Agave sisalana | Astrocytic tumour cells derived from human (GL-15) and rat (C6) gliomas, as well as non-tumoural astrocytic cells, were exposed to the saponin-rich fraction (SF) from Agave sisalana waste and the cytotoxic effects were evaluated. Cytotoxicity assays revealed a reduction of cell viability that was more intensive in glio... | ['Agave', 'Animals', 'Antineoplastic Agents, Phytogenic', 'Astrocytes', 'Cell Line, Tumor', 'Chlorocebus aethiops', 'Cytoplasm', 'Glioma', 'Humans', 'Molecular Structure', 'Plant Extracts', 'Rats', 'Saponins', 'Spectrometry, Mass, Electrospray Ionization', 'Tandem Mass Spectrometry', 'Vacuoles', 'Vero Cells'] | 29,390,916 | [['B01.650.940.800.575.912.250.618.100.060.032'], ['B01.050'], ['D27.505.954.248.179'], ['A08.637.200', 'A11.650.200'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['A11.284.430.214'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['B... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metabolism of acetaminophen (paracetamol) in plants--two independent pathways result in the formation of a glutathione and a glucose conjugate. | BACKGROUND, AIM, AND SCOPE: Pharmaceuticals and their metabolites are detected in the aquatic environment and our drinking water supplies. The need for high quality drinking water is one of the most challenging problems of our times, but still only little knowledge exists on the impact of these compounds on ecosystems,... | ['Acetaminophen', 'Anti-Inflammatory Agents, Non-Steroidal', 'Armoracia', 'Cells, Cultured', 'Glucose', 'Glutathione', 'Kinetics', 'Molecular Structure', 'Plant Roots'] | 19,145,453 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['B01.650.940.800.575.912.250.157.175'], ['A11.251'], ['D09.947.875.359.448'], ['D12.644.456.448'], ['G01.374.661', 'G02.111.490'], ['G02.111.570', 'G02.466'], ['A18.400']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synergetic effects of nanoporous support and urea on enzyme activity. | We report synergetic effects of functionalized mesoporous silica (FMS) and urea to promote favorable protein conformational changes. The specific activity of glucose isomerase (GI) entrapped in FMS in the presence of urea was approximately double that of GI in solution in the absence of urea. Rather than losing all act... | ['Adsorption', 'Aldose-Ketose Isomerases', 'Enzyme Activation', 'Enzymes, Immobilized', 'Materials Testing', 'Nanostructures', 'Particle Size', 'Porosity', 'Protein Binding', 'Silicon Dioxide', 'Urea'] | 17,341,123 | [['G01.030', 'G02.020'], ['D08.811.399.475.200'], ['G02.111.263', 'G03.328'], ['D08.811.180', 'D12.776.463.500'], ['E05.570'], ['J01.637.512'], ['G02.712'], ['G01.374.710'], ['G02.111.679', 'G03.808'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725'], ['D02.065.950']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The paralogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis. | The redox-sensing MarR/DUF24-type repressor YodB controls expression of the azoreductase AzoR1 and the nitroreductase YodC that are involved in detoxification of quinones and diamide in Bacillus subtilis. In the present paper, we identified YodB and its paralog YvaP (CatR) as repressors of the yfiDE (catDE) operon enco... | ['Bacillus subtilis', 'Bacterial Proteins', 'Blotting, Northern', 'Blotting, Western', 'Catechol 2,3-Dioxygenase', 'DNA Footprinting', 'DNA-Binding Proteins', 'Electrophoresis, Polyacrylamide Gel', 'Electrophoretic Mobility Shift Assay', 'Gene Expression Regulation, Bacterial', 'Immunoprecipitation', 'Protein Binding',... | 20,639,328 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D12.776.097'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cellular Antisense Activity of PNA-Oligo(bicycloguanidinium) Conjugates Forming Self-Assembled Nanoaggregates. | A series of peptide nucleic acid-oligo(bicycloguanidinium) (PNA-BGn ) conjugates were synthesized and characterized in terms of cellular antisense activity by using the pLuc750HeLa cell splice correction assay. PNA-BG4 conjugates exhibited low micromolar antisense activity, and their cellular activity required the pres... | ['Base Sequence', 'Biological Transport', 'Guanidine', 'HeLa Cells', 'Humans', 'Nanoparticles', 'Oligonucleotides, Antisense', 'Peptide Nucleic Acids', 'RNA Splicing'] | 26,010,253 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G03.143'], ['D02.078.370.472'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.637.512.600'], ['D13.150.480', 'D13.444.600.150.640', 'D13.695.578.424.480', 'D27.720.470.530.600.150.640'],... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Glut1 promotes cell proliferation, migration and invasion by regulating epidermal growth factor receptor and integrin signaling in triple-negative breast cancer cells. | Elevated glucose levels in cancer cells can be attributed to increased levels of glucose transporter (GLUT) proteins. Glut1 expression is increased in human malignant cells. To investigate alternative roles of Glut1 in breast cancer, we silenced Glut1 in triple-negative breast-cancer cell lines using a short hairpin RN... | ['Apoptosis', 'Breast Neoplasms', 'Cell Culture Techniques', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'ErbB Receptors', 'Female', 'Gene Expression Regulation, Neoplastic', 'Gene Knockdown Techniques', 'Glucose Transporter Type 1', 'Humans', 'Integrins', 'RNA, Small I... | 27,931,517 | [['G04.146.954.035'], ['C04.588.180', 'C17.800.090.500'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['D08.811.913.696.620.682.72... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Profiling muscle-specific microRNA expression after peripheral denervation and reinnervation in a rat model. | MicroRNAs (miRNAs) are a class of highly conserved, non-coding RNAs involved in post-transcriptional gene regulation. The muscle-specific miRNAs, miR-1, miR-133a, and miR-206, are expressed in skeletal muscles and have been shown to contribute to muscle development. To profile their expression after sciatic nerve dener... | ['Animals', 'Disease Models, Animal', 'Down-Regulation', 'Gene Expression Regulation', 'MADS Domain Proteins', 'MEF2 Transcription Factors', 'Male', 'MicroRNAs', 'Muscle Denervation', 'Muscle Fibers, Slow-Twitch', 'Muscle Proteins', 'Muscle, Skeletal', 'Myogenic Regulatory Factors', 'Nerve Regeneration', 'Neuronal Plas... | 19,586,368 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308'], ['D12.776.260.400.249', 'D12.776.930.397'], ['D12.776.210.500.570.294', 'D12.776.260.103.750.294', 'D12.776.260.400.249.624', 'D12.776.930.125.750.294', 'D12.776.930.397.700'], ['D13.150.650.319'... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endothelial Cell mTOR Complex-2 Regulates Sprouting Angiogenesis. | Tumor neovascularization is targeted by inhibition of vascular endothelial growth factor (VEGF) or the receptor to prevent tumor growth, but drug resistance to angiogenesis inhibition limits clinical efficacy. Inhibition of the phosphoinositide 3 kinase pathway intermediate, mammalian target of rapamycin (mTOR), also i... | ['Actin Cytoskeleton', 'Actins', 'Carcinoma, Renal Cell', 'Cell Adhesion', 'Cell Line, Tumor', 'Cell Movement', 'Coculture Techniques', 'Focal Adhesion Kinase 1', 'Gene Expression Regulation', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Indoles', 'Mechanistic Target of Rapamycin Complex 1', 'Mechanistic Target... | 26,295,809 | [['A11.284.430.214.190.750.050'], ['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['G04.022'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chronic Diseases in High-Cost Users of Hospital, Primary Care, and Prescription Medication in the Capital Region of Denmark. | BACKGROUND: A small proportion of patients account for the majority of health care costs. This group is often referred to as high-cost users (HCU). A frequently described characteristic of HCU is chronic disease. Yet, there is a gap in understanding the economic burden of chronic diseases associated with HCU to differe... | ['Adult', 'Aged', 'Aged, 80 and over', 'Chronic Disease', 'Cost of Illness', 'Cross-Sectional Studies', 'Denmark', 'Female', 'Health Care Costs', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Multimorbidity', 'Prescription Drugs', 'Primary Health Care', 'Registries', 'Young Adult'] | 31,512,179 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.291.500'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['Z01.542.816.124'], ['N03.219.151.400', 'N05.300.375'], ['E02.76... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected]. | The large tumor suppressor 1 (LATS1) is a serine/threonine kinase and tumor suppressor found down-regulated in a broad spectrum of human cancers. LATS1 is a central player of the emerging Hippo-LATS suppressor pathway, which plays important roles in cell proliferation, apoptosis, and stem cell differentiation. Despite ... | ['Animals', 'Apoptosis', 'COS Cells', 'Cell Proliferation', 'Chlorocebus aethiops', 'Enzyme Stability', 'HEK293 Cells', 'HeLa Cells', 'Humans', 'Neoplasms', 'Proteasome Endopeptidase Complex', 'Protein Binding', 'Protein-Serine-Threonine Kinases', 'Repressor Proteins', 'Signal Transduction', 'Tumor Suppressor Proteins'... | 21,383,157 | [['B01.050'], ['G04.146.954.035'], ['A11.251.210.172.500', 'A11.329.228.220'], ['G04.161.750', 'G07.345.249.410.750'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['E05.916.360', 'G02.111.700.500'], ['A11.251.210.172.750', 'A11.436.334'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Urinary 2-thiothiazolidine-4-carboxylic acid (TTCA) as the major urinary marker of carbon disulfide vapor exposure in rats. | Male Sprague-Dawley rats (200-250 g; 60 per exposure group) were exposed to carbon disulfide (CS2) air concentrations of 0, 50, 150, and 500 ppm(v/v) for 6 hr/day, 5 days/week over six months. Following the exposures, nine rats from each exposure group had four sets of cumulated urines collected (between 0-8, 8-16, 16-... | ['Administration, Oral', 'Animals', 'Azides', 'Biomarkers', 'Carbon Disulfide', 'Dose-Response Relationship, Drug', 'Gases', 'Iodine', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Sulfides', 'Thiazoles', 'Thiazolidines', 'Time Factors'] | 8,713,716 | [['E02.319.267.100'], ['B01.050'], ['D01.625.100', 'D02.159'], ['D23.101'], ['D01.200.210', 'D01.875.350.850.074'], ['G07.690.773.875', 'G07.690.936.500'], ['D01.362'], ['D01.268.380.400'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D01.248.497.158.874', 'D01.875.350... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors affecting atrazine concentration and quantitative determination in chlorinated water. | Although the herbicide atrazine has been reported to not react measurably with free chlorine during drinking water treatment, this work demonstrates that at contact times consistent with drinking water distribution system residence times, a transformation of atrazine can be observed. Some transformation products detect... | ['Atrazine', 'Chlorine', 'Chromatography, High Pressure Liquid', 'Halogenation', 'Hydrogen-Ion Concentration', 'Kinetics', 'Oxidation-Reduction', 'Sensitivity and Specificity', 'Water', 'Water Supply'] | 20,022,012 | [['D03.383.931.247'], ['D01.268.380.150', 'D01.362.225'], ['E05.196.181.400.300'], ['G02.111.323', 'G03.360'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['G02.700', 'G03.295.531'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Salicylate as an in vivo free radical trap: studies on ischemic insult to the rat intestine. | Ischemia of rat intestine was induced in vivo by occlusion of the superior mesenteric artery (SMA) for 15 min. Sodium salicylate, 100 mg/kg, given IP, 30 min prior to the ischemic event served as a specific trap for hydroxyl radicals. Portions of the bowel were sequentially isolated and removed--2 min prior to ischemia... | ['Animals', 'Disease Models, Animal', 'Free Radicals', 'Gentisates', 'Hydroxides', 'Hydroxybenzoates', 'Hydroxyl Radical', 'Intestines', 'Male', 'Rats', 'Reperfusion Injury', 'Salicylates', 'Salicylic Acid'] | 1,646,748 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D01.339', 'D02.389'], ['D02.241.223.100.300.595.405', 'D02.241.511.390.595.405', 'D02.455.426.559.389.127.281.595.405', 'D02.455.426.559.389.657.410.595.405'], ['D01.045.250', 'D01.248.497.158.459'], ['D02.241.223.100.300', 'D02.241.511.390', 'D02.455.426.5... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anastomotic healing of small bowel with or without chronic radiation damage in protein-deficient malnourished rats. | OBJECTIVE: To assess the influence of protein malnutrition on anastomotic healing in rat small bowel with or without chronic radiation damage.DESIGN: Controlled laboratory study.SETTING: University hospital, Sweden.MATERIAL: 60 male Sprague-Dawley rats.INTERVENTION: A short segment of the distal ileum was exteriorised ... | ['Anastomosis, Surgical', 'Animals', 'Biomechanical Phenomena', 'Intestine, Small', 'Male', 'Protein Deficiency', 'Radiation Injuries, Experimental', 'Rats', 'Rats, Sprague-Dawley', 'Wound Healing'] | 8,679,763 | [['E04.035'], ['B01.050'], ['G01.154.090', 'G01.374.089'], ['A03.556.124.684'], ['C18.654.521.500.708'], ['C26.733.720', 'E05.598.500.750', 'G01.750.748.500.720', 'N06.850.460.350.850.500.285', 'N06.850.810.300.360.285'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['G1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Potentially inappropriate prescribing and associated factors in elderly patients at hospital discharge in Brazil: a cross-sectional study. | Background The Screening Tool of Older Persons' Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) criteria is used to identify instances of potentially inappropriate prescribing in a patient's medication regimen. Objective To determine the prevalence and predictors of potentially inappropri... | ['Aged', 'Aged, 80 and over', 'Brazil', 'Cross-Sectional Studies', 'Female', 'Humans', 'Inappropriate Prescribing', 'Male', 'Middle Aged', 'Patient Discharge', 'Potentially Inappropriate Medication List', 'Prevalence', 'Risk Factors'] | 28,188,508 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.107.757.176'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.490', 'N02.421.450.500.249'], ['M01.060.116.630'], ['E02.760.169.125', 'E02.760.400.610', 'N02.421.585.169.125', '... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Cocrystal structure of an editing complex of Klenow fragment with DNA. | High-resolution crystal structures of editing complexes of both duplex and single-stranded DNA bound to Escherichia coli DNA polymerase I large fragment (Klenow fragment) show four nucleotides of single-stranded DNA bound to the 3'-5' exonuclease active site and extending toward the polymerase active site. Melting of t... | ['Computer Simulation', 'DNA', 'DNA Polymerase I', 'DNA, Single-Stranded', 'Models, Molecular', 'Nucleic Acid Conformation', 'Protein Binding', 'Protein Conformation', 'X-Ray Diffraction'] | 3,194,400 | [['L01.224.160'], ['D13.444.308'], ['D08.811.913.696.445.308.300.225'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['E05.599.595'], ['G02.111.570.820.486', 'G05.360.580'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.965']] | ['Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Differential response of arteries and veins to bipolar vessel sealing: evaluation of a novel reusable device. | BACKGROUND: A variety of energy-based techniques for arterial and venous vessel ligation have recently been introduced. Using a porcine model we studied the efficacy of the novel reusable BiClamp versus the standard disposable LigaSure bipolar vessel sealing device. We also compared whether arteries respond differently... | ['Animals', 'Arteries', 'Equipment Reuse', 'Kidney', 'Ligation', 'Nephrectomy', 'Spleen', 'Splenectomy', 'Statistics, Nonparametric', 'Surgical Instruments', 'Swine', 'Vascular Surgical Procedures', 'Veins'] | 16,646,707 | [['B01.050'], ['A07.015.114'], ['E05.328', 'N06.850.585'], ['A05.810.453'], ['E04.426'], ['E04.950.774.435'], ['A10.549.700', 'A15.382.520.604.700'], ['E04.726'], ['E05.318.740.995', 'N05.715.360.750.760', 'N06.850.520.830.995'], ['E07.858.700'], ['B01.050.150.900.649.313.500.880'], ['E04.100.814'], ['A07.015.908']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Stimulation of non-alpha7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture. | Previous work has shown that nicotine treatment protects against nigrostriatal degeneration in rodents, findings that may be of relevance to the decreased incidence of Parkinson's disease in cigarette smokers. In the present studies, we investigated the effect of nicotine against 1-methyl-4-phenylpyridinium-induced tox... | ['1-Methyl-4-phenylpyridinium', 'Animals', 'Cell Death', 'Dopamine', 'Female', 'Immunohistochemistry', 'Neurons', 'Neuroprotective Agents', 'Nicotine', 'Organ Culture Techniques', 'Parkinson Disease', 'Pregnancy', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Nicotinic', 'Substantia Nigra', 'Tobacco Use Disorder', 'Tyros... | 11,801,364 | [['D03.383.725.762.550'], ['B01.050'], ['G04.146'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.51... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
FDA Benchmark Medical Device Flow Models for CFD Validation. | Computational fluid dynamics (CFD) is increasingly being used to develop blood-contacting medical devices. However, the lack of standardized methods for validating CFD simulations and blood damage predictions limits its use in the safety evaluation of devices. Through a U.S. Food and Drug Administration (FDA) initiativ... | ['Benchmarking', 'Heart-Assist Devices', 'Humans', 'Hydrodynamics', 'Models, Theoretical', 'Rheology', 'United States', 'United States Food and Drug Administration'] | 28,114,192 | [['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['E04.050.430', 'E07.695.300.300', 'E07.858.082.374.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.342'], ['E05.599'], ['E05.830', 'H01.671.808'], ['Z01.107.567.875'], ['I01.409.418.750.600.650.760', 'N03.54... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. | Neurofibromatosis type one (NF1) is a common genetic disorder affecting 1:4000 births and is characterized by benign and malignant tumors. Children with NF1 are predisposed to juvenile myelomonocytic leukemia. The Nf1 gene encodes neurofibromin, which can function as a Ras GTPase-activating protein. Neurofibromin defic... | ['Alleles', 'Animals', 'Child', 'Disease Models, Animal', 'Gene Silencing', 'Genes, Neurofibromatosis 1', 'Hematopoietic Stem Cells', 'Humans', 'Integrases', 'Leukemia, Myelomonocytic, Chronic', 'Leukocytes', 'Mice', 'Mice, Transgenic', 'Myeloproliferative Disorders', 'Receptor, TIE-2', 'Spleen'] | 14,739,366 | [['G05.360.340.024.340.030'], ['B01.050'], ['M01.060.406'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.308.203.374'], ['G05.360.340.024.340.375.249.340', 'G05.360.340.024.340.415.400.340'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.739.500'],... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Validating a 7-channel ambulatory polygraphy unit. 1: Operating instructions for the physician and patient]. | PURPOSE: For some time, the ambulatory diagnosis of sleep-related breathing disorders has included the use of seven-channel recording units. One such unit is the POLY-MESAM (MAP, Martinsried, FRG). The first part of the present study prospectively investigated the handling of the system for physicians and patients, its... | ['Adult', 'Aged', 'Ambulatory Care', 'Computer Systems', 'Equipment Design', 'Female', 'Humans', 'Male', 'Middle Aged', 'Polysomnography', 'Sensitivity and Specificity', 'Signal Processing, Computer-Assisted', 'Sleep Apnea Syndromes', 'Software'] | 10,407,729 | [['M01.060.116'], ['M01.060.116.100'], ['E02.760.106', 'N02.421.585.106'], ['L01.224.230'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.520.625'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Coronary score adds prognostic information for patients with acute coronary syndrome. | BACKGROUND: The aim of the present study was to explore the association of 3 coronary scores with major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS).METHODS AND RESULTS: The 958 consecutive patients with ACS were followed up until either MACE or 31(st) December 2008 occurred; 257 ... | ['Acute Coronary Syndrome', 'Aged', 'Coronary Angiography', 'Death, Sudden, Cardiac', 'Female', 'Follow-Up Studies', 'Heart Failure', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Patient Readmission', 'Prognosis', 'Proportional Hazards Models', 'ROC Curve', 'Risk Factors', 'Sensitivity ... | 20,057,158 | [['C14.280.647.124', 'C14.907.585.124'], ['M01.060.116.100'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.383.220', 'C23.550.260.322.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C14.280.434'], ['B01.05... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Synthesis of phosphatidylserine in carrot cells cultured under carbon-source starvation. | When carrot suspension cells were cultured on medium containing no carbon source (starvation), the levels of phosphatidylserine (PS) increased transiently 3-4 d after the initiation of starvation while levels of most other phospholipid (PL) species decreased. We previously reported that fatty acids of these PLs served ... | ['CDPdiacylglycerol-Serine O-Phosphatidyltransferase', 'Carbon', 'Cells, Cultured', 'Culture Media', 'Daucus carota', 'Phosphatidylserines', 'Plant Leaves', 'Serine'] | 11,148,273 | [['D08.811.913.696.900.150'], ['D01.268.150'], ['A11.251'], ['D27.720.470.305', 'E07.206'], ['B01.650.940.800.575.912.250.075.278'], ['D10.570.755.375.760.400.971'], ['A18.024.812'], ['D12.125.154.800']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolation and characterization of cadmium-resistant mutants of Neurospora crassa. | This study identified and characterized four cadmium-resistant mutants of Neurospora crassa. One of these mutants maps to linkage group II and the other three map to linkage group VII, whereas a naturally occurring resistant trait in a strain from Japan resides at a distinct but unmapped locus. Transport of cadmium int... | ['Biological Transport, Active', 'Cadmium', 'Drug Resistance, Microbial', 'Fungal Proteins', 'Heat-Shock Proteins', 'Mutation', 'Neurospora', 'Neurospora crassa'] | 2,525,066 | [['G03.143.310'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['G06.225', 'G07.690.773.984.269'], ['D12.776.354'], ['D12.776.580.216'], ['G05.365.590'], ['B01.300.107.800.629'], ['B01.300.107.800.629.564']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Electric field modulation in tissue electroporation with electrolytic and non-electrolytic additives. | Electroporation, cell membrane permeabilization with short electrical field pulses, is used in tissue for in vivo gene therapy, drug therapy and minimally invasive tissue ablation. For the electroporation to be successful, the electrical field that develops during the application of the pulses needs to be precisely con... | ['Animals', 'Computer Simulation', 'Electrolytes', 'Electromagnetic Fields', 'Electroporation', 'Finite Element Analysis', 'Gels', 'Liver', 'Male', 'Models, Biological', 'Rats', 'Rats, Sprague-Dawley'] | 17,350,351 | [['B01.050'], ['L01.224.160'], ['D01.248'], ['G01.358.500.260', 'G01.358.750.500'], ['E05.200.500.454', 'E05.242.448', 'E05.301.500'], ['E05.355'], ['D20.280.320', 'D26.255.165.320'], ['A03.620'], ['E05.599.395'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750']] | ['Organisms [B]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Affinity modulation of human placental insulin and insulin-like growth factor receptors by lectins. | The ability of plant lectins to modify the interactions of the insulin receptor (IR) and insulin-like growth factor (IGF) receptors (IGFRs) with their ligands was investigated. The lectins profoundly affected the competition-binding curves for (125)I-labelled IGF-I and insulin, causing an increase in the affinity of pl... | ['Animals', 'Binding, Competitive', 'Cell Membrane', 'Female', 'Humans', 'Insulin', 'Insulin-Like Growth Factor I', 'Insulin-Like Growth Factor II', 'Iodine Radioisotopes', 'Lectins', 'Placenta', 'Pregnancy', 'Radioligand Assay', 'Receptor, IGF Type 1', 'Receptor, IGF Type 2', 'Receptor, Insulin'] | 18,316,333 | [['B01.050'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['A11.284.149'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['D12.644.276.937.400', 'D12.776.124.862.400', 'D12.776.467.937.400', 'D23.529.937.400'], ['D12.644.276.937.420', 'D12.77... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[SIRS and ARDS as a result of drug injection in the shoulder region]. | Bacterial infections with local inflammation or hematogenous spreading may occur after joint punctures and intra- or periarticular injections. The risk of severe infections increases in patients with diseases accompanied by low immunity, e.g., gout, alcoholism, rheumatoid arthritis, and diabetes mellitus. Cases of sept... | ['Adult', 'Aged', 'Bacterial Infections', 'Female', 'Humans', 'Injections', 'Respiratory Distress Syndrome', 'Shoulder Joint', 'Systemic Inflammatory Response Syndrome'] | 18,043,902 | [['M01.060.116'], ['M01.060.116.100'], ['C01.150.252'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530'], ['C08.381.840', 'C08.618.840'], ['A02.835.583.748'], ['C23.550.470.790', 'C23.550.835.900']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Metastatic non-functional paraganglioma to the lung. | INTRODUCTION: Paragangliomas are rare endocrine tumors that arise from the extra-adrenal autonomic paraganglia and sympathetic paragangliomas usually secret catecholamines and are located in the sympathetic paravertebral ganglia of thorax, abdomen, and pelvis. In contrast, most parasympathetic paragangliomas are nonfun... | ['Adult', 'Brain', 'Humans', 'Lung Neoplasms', 'Magnetic Resonance Imaging', 'Male', 'Multiple Pulmonary Nodules', 'Neoplasm Metastasis', 'Neoplasm Recurrence, Local', 'Paraganglioma', 'Tomography, X-Ray Computed', 'Treatment Outcome'] | 32,393,294 | [['M01.060.116'], ['A08.186.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['E01.370.350.825.500'], ['C04.588.894.797.520.237', 'C08.381.540.148', 'C08.785.520.148'], ['C04.697.650', 'C23.550.727.650'], ['C04.697.655', 'C23.550.727.655'], ['C04.557.465.625... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study. | BACKGROUND: NUT carcinoma is a rare aggressive disease caused by BRD4/3-NUT fusion, and C-MYC upregulation plays a key role in the pathogenesis. Here, we report on the clinicopathological characteristics of Korean patients with NUT carcinoma and the in vitro efficacy of MYC-targeting agents against patient-derived NUT ... | ['Adolescent', 'Adult', 'Aged', 'Cell Line, Tumor', 'Cell Proliferation', 'Child', 'Female', 'Head and Neck Neoplasms', 'Heterocyclic Compounds, 2-Ring', 'Histone Deacetylase Inhibitors', 'Humans', 'Immunohistochemistry', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Morpholines', 'Nuclear Proteins', 'Oncogene Proteins, Fu... | 30,696,721 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['M01.060.406'], ['C04.588.443'], ['D03.633.100'], ['D27.505.519.389.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells. | Pleiotrophin (PTN) augments tumor growth by increasing proliferation of tumor cells and promoting vascular abnormalization, but its role in early gliomagenesis has not been evaluated. Through analysis of publically available datasets, we demonstrate that increased PTN mRNA expression is associated with amplification of... | ['Animals', 'Avian Proteins', 'Avian Sarcoma Viruses', 'Brain Neoplasms', 'Carrier Proteins', 'Cell Proliferation', 'Cells, Cultured', 'Chromosomes, Human, Pair 7', 'Cyclin-Dependent Kinase Inhibitor p16', 'Cytokines', 'Gene Amplification', 'Gene Expression Regulation, Neoplastic', 'Genetic Predisposition to Disease', ... | 27,806,344 | [['B01.050'], ['D12.776.095'], ['B04.613.807.070.120', 'B04.820.650.070.120'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['D12.776.157'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['A11.284.187.520.300.325.335', 'G05.360.162.520.300.325.335'], ['D12.644.360.225.200', 'D12.776.167.187.200... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Real-Time Visualization of Cysteine Metabolism in Living Cells with Ratiometric Fluorescence Probes. | Sulfite from cysteine metabolism in living cells plays a crucial role in improving the water solubility of metabolic xenobiotics for their easier excretion in urine or bile. However, an imbalance of sulfite in vivo would lead to oxidative stress or age-related diseases, and an effective strategy for real-time imaging o... | ['Cell Survival', 'Cysteine', 'Fluorescent Dyes', 'HeLa Cells', 'Humans', 'Microscopy, Confocal', 'Optical Imaging', 'Spectrometry, Fluorescence', 'Sulfites', 'Time Factors'] | 29,363,304 | [['G04.346'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.395', 'E05.595.395'], ['E01.370.350.589', 'E05.642... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neuropsychological predictors of powered wheelchair use: a prospective follow-up study. | OBJECTIVES: To investigate (1) rates of powered wheelchair use and level of user-rated functional performance at one-month follow-up, and (2) whether psychological variables were prospectively predictive of outcome.DESIGN: Prospective follow-up study.SETTING: UK hospital-based regional rehabilitation and mobility centr... | ['Aged', 'Cognition', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Multivariate Analysis', 'Neuropsychological Tests', 'Patient Acceptance of Health Care', 'Prospective Studies', 'ROC Curve', 'Regression Analysis', 'Wheelchairs'] | 18,728,137 | [['M01.060.116.100'], ['F02.463.188'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['F04.711.513'], ['F01.100.150.750.500', 'F01.145.488.887.500'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Designing misfolded proteins by energy landscaping. | Conformational fluctuations in the native state ensemble enhance the complexity in designing de novo protein sequences that may fold correctly into a desired target structure. In this work, the results of a self-consistent mean field theory are applied to a cubic lattice model of proteins and real nonhomologous protein... | ['Microfilament Proteins', 'Protein Folding', 'Protein Unfolding', 'Proteins', 'Temperature', 'Thermodynamics'] | 21,158,416 | [['D05.750.078.730', 'D12.776.220.525'], ['G01.154.651', 'G02.111.688'], ['G01.154.651.750', 'G02.111.688.750'], ['D12.776'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Taxonomic characterisation of Pseudomonas strain L48 and formal proposal of Pseudomonas entomophila sp. nov. | An entomopathogenic, Gram-negative bacterium isolated from a female specimen of the fruit fly Drosophila melanogaster was taxonomically characterised. Strain L48(T) was strictly aerobic, non-fermentative, oxidase and catalase positive, rod-shaped, and motile due to a polar inserted flagellum. Phylogenetic analysis of t... | ['Aerobiosis', 'Animals', 'Bacterial Typing Techniques', 'Catalase', 'Cluster Analysis', 'DNA, Bacterial', 'DNA, Ribosomal', 'Drosophila melanogaster', 'Flagella', 'Locomotion', 'Molecular Sequence Data', 'Nucleic Acid Hybridization', 'Oxidoreductases', 'Phylogeny', 'Pseudomonas', 'RNA, Ribosomal, 16S', 'Sequence Analy... | 22,326,814 | [['G02.111.017', 'G03.049'], ['B01.050'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['D08.811.682.732.332'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['D13.444.308.212'], ['D13.444.308.475'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['A11.284.180.290'], ['G07.568.500', 'G... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Characterization of [11C]vorozole binding in ovarian tissue in rats throughout estrous cycle in association with conversion of androgens to estrogens in vivo and in vitro. | Estrogen levels vary in a cyclic fashion during the rat estrous cycle, reaching peak concentrations during proestrus. Previously, it was suggested that the preovulatory peak in estrogen production in rats in vivo is regulated by other control mechanisms than concentration of precursor and amount of aromatase enzyme, ch... | ['Androstenedione', 'Animals', 'Aromatase', 'Aromatase Inhibitors', 'Binding Sites', 'Enzyme Inhibitors', 'Estradiol', 'Estrous Cycle', 'Estrus', 'Female', 'In Vitro Techniques', 'Luteinizing Hormone', 'Ovary', 'Radioimmunoassay', 'Rats', 'Rats, Sprague-Dawley', 'Triazoles'] | 14,643,875 | [['D04.210.500.054.079.329', 'D04.210.500.578.502.112', 'D06.472.040.502.112', 'D06.472.334.851.968.875'], ['B01.050'], ['D08.244.453.489.500', 'D08.244.453.915.099', 'D08.811.682.690.708.170.447.500', 'D08.811.682.690.708.170.915.099', 'D12.776.422.220.453.489.500', 'D12.776.422.220.453.915.099'], ['D27.505.519.389.87... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pseudomyxoma peritonei--experience from a tertiary referral centre. | Pseudomyxoma peritonei is a clinical diagnosis of massive abdominal swelling by a gelatinous material, produced usually from an ovarian or appendiceal primary. It is a rare entity that is usually histologically benign but behaves clinically in a malignant fashion with recurrent growth, although not demonstrating histol... | ['Adult', 'Aged', 'Cancer Care Facilities', 'Chemotherapy, Adjuvant', 'Combined Modality Therapy', 'Female', 'Humans', 'Middle Aged', 'Minnesota', 'Pelvic Exenteration', 'Pseudomyxoma Peritonei'] | 1,930,042 | [['M01.060.116'], ['M01.060.116.100'], ['N02.278.421.556.070'], ['E02.186.170', 'E02.319.170'], ['E02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.107.567.875.350.510', 'Z01.107.567.875.510.510'], ['E04.584'], ['C04.557.470.200.025.075.500', 'C04.557.470.590.075.500']] | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
An Unusual Case of Metastatic Seminoma in a Dog. | An 8 yr old, reportedly castrated male Boston terrier presented with a history of generalized hyperesthesia and intermittent shifting leg lameness. Physical examination revealed a caudal abdominal mass and bilateral shoulder pain. A complete blood count, serum biochemistry panel, and urinalysis were unremarkable. Thora... | ['Animals', 'Bone Neoplasms', 'Cryptorchidism', 'Dog Diseases', 'Dogs', 'Hyperesthesia', 'Lymphatic Metastasis', 'Male', 'Seminoma', 'Testicular Neoplasms'] | 26,535,460 | [['B01.050'], ['C04.588.149', 'C05.116.231'], ['C12.294.829.258', 'C12.706.258', 'C16.131.939.258', 'C19.391.829.258'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['C10.597.751.791.450', 'C23.888.592.763.770.450'], ['C04.697.650.560', 'C23.550.727.650.560'], ['C04.557.465.330.800'], ['C04.588.322.762', '... | ['Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The lateral femoral notch sign: a reliable diagnostic measurement in acute anterior cruciate ligament injury. | PURPOSE: To describe the validity and inter- and intra-observer reliability of the lateral femoral notch sign (LFNS) as measured on conventional radiographs for diagnosing acute anterior cruciate ligament (ACL) injury.METHODS: Patients (? 45 years) with a traumatic knee injury who underwent knee arthroscopy and had pre... | ['Adult', 'Anterior Cruciate Ligament Injuries', 'Anterior Cruciate Ligament Reconstruction', 'Arthroscopy', 'Athletic Injuries', 'Case-Control Studies', 'Female', 'Femur', 'Humans', 'Male', 'Observer Variation', 'Predictive Value of Tests', 'Radiography', 'Retrospective Studies'] | 30,317,524 | [['M01.060.116'], ['C26.558.554.213'], ['E04.555.110.026', 'E04.680.101.026'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['C26.115'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A02.835.232.043.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.354.753', ... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Preliminary design of a new degradable medical device to prevent the formation and recurrence of intrauterine adhesions. | Intrauterine adhesions lead to partial or complete obliteration of the uterine cavity and have life-changing consequences for women. The leading cause of adhesions is believed to be loss of stroma resulting from trauma to the endometrium after surgery. Adhesions are formed when lost stroma is replaced by fibrous tissue... | ['Adult', 'Animals', 'Cell Adhesion', 'Collagen', 'Endometrium', 'Equipment Design', 'Female', 'Humans', 'In Vitro Techniques', 'Magnetic Resonance Spectroscopy', 'Polyesters', 'Polyethylene Glycols', 'Random Allocation', 'Rats', 'Rats, Wistar', 'Recurrence', 'Tissue Adhesions', 'Uterine Diseases', 'Uterus', 'Viscosity... | 31,123,719 | [['M01.060.116'], ['B01.050'], ['G04.022'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A05.360.319.679.490'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['E05.196.867.519'], ['D05.750.728', 'D25.720.728', 'J01.637.051.720.728'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741', 'J... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Influence of ferrule preparation with or without glass fiber post on fracture resistance of endodontically treated teeth. | OBJECTIVE: This study evaluated the effect of ferrule preparation (Fp) on the fracture resistance of endodontically treated teeth, restored with composite resin cores with or without glass fiber posts.MATERIAL AND METHODS: Forty-four bovine teeth were sectioned 19 or 17 mm (2 mm ferrule) from the apex, endodontically t... | ['Animals', 'Cattle', 'Composite Resins', 'Crowns', 'Dental Alloys', 'Dental Materials', 'Dental Prosthesis Design', 'Dental Stress Analysis', 'Glass', 'Gutta-Percha', 'Post and Core Technique', 'Random Allocation', 'Root Canal Filling Materials', 'Root Canal Obturation', 'Root Canal Preparation', 'Stress, Mechanical',... | 20,835,570 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['E06.780.346.250', 'E07.695.190.088'], ['D25.339.208', 'J01.637.051.339.208'], ['D25.339', 'D27.720.102.339', 'J01.637.051.339'], ['E06.780... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Magnetic resonance imaging: a new diagnostic aid in the care of high-voltage electrical burns. | Magnetic resonance imaging (MRI) can detect and delineate alterations in the hydration properties of tissues such as oedema and necrosis. The distinction between living tissue oedema and frank necrosis is also possible with MRI, by use of a spin-echo (SE) sequence and a fast spin-echo (FSE) sequence with a 1.5 T imager... | ['Adult', 'Burns, Electric', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Muscles', 'Necrosis', 'Skin'] | 8,634,117 | [['M01.060.116'], ['C26.200.239', 'C26.324.323'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['A02.633', 'A10.690'], ['C23.550.717'], ['A17.815']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lack of evidence of Epstein-Barr virus infection in patients with Castleman's disease. Molecular genetic analysis. | OBJECTIVE: Epstein-Barr virus (EBV) infection is associated with a diverse group of malignancies and many lymphoproliferative disorders. Castleman's disease (CD) is atypical lymphoproliferative disorder. The role of EBV in the pathogenesis of CD is not clear yet. The objective of this study is to investigate the EBV st... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Canada', 'Castleman Disease', 'Female', 'Herpesviridae Infections', 'Herpesvirus 4, Human', 'Humans', 'Immunohistochemistry', 'Lymph Nodes', 'Male', 'Middle Aged', 'Molecular Biology', 'Polymerase Chain Reaction', 'Saudi Arabia', 'Tumor Virus Infections'] | 16,883,438 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.107.567.176'], ['C15.604.515.245', 'C20.683.515.250'], ['C01.925.256.466'], ['B04.280.210.400.500.450', 'B04.280.382.400.500.400', 'B04.613.204.500.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 |
In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. | The intramembrane aspartyl protease gamma-secretase plays a fundamental role in several signaling pathways involved in cellular differentiation and has been linked with a variety of human diseases, including Alzheimer's disease. Here, we describe a transgenic Drosophila model for in vivo-reconstituted gamma-secretase, ... | ['Amyloid Precursor Protein Secretases', 'Animals', 'Animals, Genetically Modified', 'Drosophila Proteins', 'Drosophila melanogaster', 'Humans', 'Membrane Glycoproteins', 'Membrane Proteins', 'Phenotype', 'Presenilins', 'Signal Transduction', 'Substrate Specificity'] | 20,421,416 | [['D08.811.277.656.300.032'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550', 'D12.776.543.550'], ['D12.776.543'], ['G05.695'], ['D12.776.543.696'], ['G02.111.820', 'G04.83... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hypertrophic lymphocytic gastritis with a gastric carcinoma. | Lymphocytic gastritis is a recently described gastric inflammation, characterized by an increased intraepithelial lymphocytic infiltrate mainly composed of T-lymphocytes. Endoscopically it correlates mainly with diffuse varioliform gastritis. M?n?trier's disease is a hypertrophic gastropathy with enlarged gastric folds... | ['Adenocarcinoma', 'Fatal Outcome', 'Gastritis, Hypertrophic', 'Humans', 'Lymphocytes', 'Male', 'Middle Aged', 'Stomach Neoplasms', 'Tomography, X-Ray Computed'] | 9,831,277 | [['C04.557.470.200.025'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['C06.405.205.697.410', 'C06.405.748.398.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['M01.06... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of corticosteroids on dendritic development in the rat brain. | Sprague-Dawley rats were given 0.02 ml of methylprednisolone (0.06 g/g body wt) 6, 9, or 12 days postnatally. When compared with saline-treated controls, the following effects on dendritic development in layers 3 and 5 of the parietal cortex were observed: (1) no significant alteration in number of basal dendrites; (2)... | ['Animals', 'Dendrites', 'Methylprednisolone', 'Parietal Lobe', 'Pyramidal Tracts', 'Rats', 'Sodium Chloride', 'Time Factors'] | 4,446,628 | [['B01.050'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['D04.210.500.745.432.769.795.539'], ['A08.186.211.200.885.287.500.670'], ['A08.186.854.300', 'A08.612.380.730'], ['B01.050.150.900.649.313.992.635.505.700'], ['D01.210.450.150.875', 'D01.857.650'], ['G01.910.857']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The mouse ovarian surface epithelium cells (MOSE) transformation induced by c-myc/K-ras in]. | OBJECTIVE: To study the function of c-myc and K-ras in tumorigenesis of ovarian cancer.METHODS: K-ras and/or c-myc cDNAs were introduced into mouse ovarian surface epithelium cells (MOSE) using recombinant Moloney retroviral vectors. The resulting MOSE cells were studied by cell proliferation assays, the ability to for... | ['Animals', 'Blotting, Western', 'Cell Movement', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Epithelial Cells', 'Female', 'Immunohistochemistry', 'Mice', 'Mice, Nude', 'Mice, Transgenic', 'Neoplasms, Experimental', 'Oncogene Protein p21(ras)', 'Ovarian Neoplasms', 'Ovary', 'Proto-Oncog... | 17,533,735 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['A11.436'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Aluminum-induced degeneration of astrocytes occurs via apoptosis and results in neuronal death. | The mechanisms by which aluminum interacts with the nervous system are only partly understood. In this study, we used cultured astrocytes and neurons to investigate the effects of long exposures to aluminum (1 mM). We found that aluminum accumulated both in neurons and astrocytes. After 8-12 days exposure, aluminum cau... | ['Aluminum', 'Animals', 'Apoptosis', 'Astrocytes', 'Cell Death', 'Cells, Cultured', 'Coculture Techniques', 'DNA Fragmentation', 'Nerve Degeneration', 'Neuroglia', 'Neurons', 'Rats'] | 10,415,367 | [['D01.268.557.050', 'D01.552.547.050'], ['B01.050'], ['G04.146.954.035'], ['A08.637.200', 'A11.650.200'], ['G04.146'], ['A11.251'], ['E05.481.500.374'], ['G05.200.230'], ['C23.550.737'], ['A08.637', 'A11.650'], ['A08.675', 'A11.671'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intussusception in southern Indian children: lack of association with diarrheal disease and oral polio vaccine immunization. | BACKGROUND: Intussusception is the most common cause of intestinal obstruction in young children and has been reported as a complication of a recently withdrawn tetravalent reassortant rotavirus vaccine.METHODS: We studied the history, clinical presentation, management and outcome of intussusception presenting to a ter... | ['Case-Control Studies', 'Child Welfare', 'Child, Preschool', 'Diarrhea', 'Female', 'Humans', 'Ileal Diseases', 'Ileocecal Valve', 'Immunization', 'India', 'Infant', 'Infant Welfare', 'Intussusception', 'Male', 'Poliomyelitis', 'Poliovirus Vaccine, Oral', 'Retrospective Studies', 'Treatment Outcome'] | 12,839,377 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['I01.880.787.293'], ['M01.060.406.448'], ['C23.888.821.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.420'], ['A03.556.124.684.249.400', 'A03.556.249.124.400'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Optimization of culture conditions for 1,3-propanediol production from glycerol using a mutant strain of Klebsiella pneumoniae. | In the present work, mutant strains of Klebsiella pneumoniae with deletions of the als gene encoding acetolactate synthase involved in synthesis of 2,3-butanediol, the ldhA gene encoding lactate dehydrogenase required for lactate synthesis, or both genes, were prepared. Production of 1,3-propanediol (1,3-PD) from glyce... | ['Acetolactate Synthase', 'Batch Cell Culture Techniques', 'Butylene Glycols', 'Fermentation', 'Glycerol', 'Hydrogen-Ion Concentration', 'Klebsiella pneumoniae', 'L-Lactate Dehydrogenase', 'Mutation', 'Propylene Glycols'] | 22,072,138 | [['D08.811.913.200.324', 'D12.776.331.049'], ['E05.481.500.249.124'], ['D02.033.455.125'], ['G02.111.158.249', 'G03.191.249'], ['D02.033.800.875.500', 'D09.853.875.500'], ['G02.300'], ['B03.440.450.425.425.600', 'B03.660.250.150.400.590'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['G05.365.590'], ['D02.0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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