Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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The rhizomes of Alisma orientale and alisol derivatives inhibit allergic response and experimental atopic dermatitis. | The 70% ethanol extract of the rhizome of Alisma orientale (Alismatis rhizome) (AOE) was prepared and found to significantly inhibit 5-lipoxygenase (5-LOX)-catalyzed leukotriene (LT) production from rat basophilic leukemia (RBL)-1 cells and â-hexosaminidase release by antigen-stimulated RBL-2H3 cells. It also attenuate... | ['Alisma', 'Animals', 'Antigens', 'Arachidonate 5-Lipoxygenase', 'Cell Line, Tumor', 'Cholestenones', 'Dermatitis, Atopic', 'Disease Models, Animal', 'Haptens', 'Hypersensitivity, Delayed', 'Leukemia', 'Leukotrienes', 'Male', 'Mice', 'Mice, Inbred ICR', 'Mice, Inbred Strains', 'Phytotherapy', 'Plant Extracts', 'Rhizome... | 22,975,512 | [['B01.650.940.800.575.912.250.618.050.625.044'], ['B01.050'], ['D23.050'], ['D08.811.682.690.416.583.500.055', 'D12.776.556.579.374.568.500.020'], ['A11.251.210.190', 'A11.251.860.180'], ['D04.210.500.247.222.265'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['C22.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alamethicin-induced current-voltage curve asymmetry in lipid bilayers. | We have examined the causes of the asymmetry of the current-voltage curve induced by addition of alamethicin to one side of a black lipid membrane. We find that the alamethicin-induced current-voltage (I-V) curve has an inherent asymmetry. If it were possible to confine all alamethicin molecules to one side of the memb... | ['Alamethicin', 'Anti-Bacterial Agents', 'Lipid Bilayers', 'Mathematics', 'Membrane Potentials', 'Models, Biological'] | 6,838,983 | [['D04.345.566.040', 'D12.644.504.111', 'D12.644.641.040'], ['D27.505.954.122.085'], ['D10.570.510', 'J01.637.087.500.510'], ['H01.548'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.599.395']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Towards a solution of the wires' slippage problem of the Ilizarov external fixator. | Clinical experience has indicated that many complications during treatment with the Ilizarov method, and mainly tract infection, are related to decreased wire tension. The aim of this work was to evaluate biomechanically a novel wire tensioning and clamping system that will minimise or even diminish the reduction of th... | ['Bone Wires', 'Elasticity', 'Equipment Design', 'Equipment Failure', 'External Fixators', 'Humans', 'Ilizarov Technique', 'Materials Testing', 'Stress, Mechanical', 'Tensile Strength', 'Weight-Bearing'] | 25,139,115 | [['E07.695.370.468', 'E07.858.442.660.460.468', 'E07.858.690.725.460.468'], ['G01.374.590'], ['E05.320'], ['E05.325'], ['E07.858.442.660.430', 'E07.858.690.725.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.555.120.380', 'E04.555.300.380'], ['E05.570'], ['G01.374.835'], ['G01.374.850'], ['G01.374.965']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The developmental stage of the hematopoietic niche regulates lineage in MLL- | Leukemia phenotypes vary with age of onset. Delineating mechanisms of age specificity in leukemia could improve disease models and uncover new therapeutic approaches. Here, we used heterochronic transplantation of leukemia driven by MLL/KMT2A translocations to investigate the contribution of the age of the hematopoieti... | ['Aging', 'Animals', 'Animals, Newborn', 'B-Lymphocytes', 'Chemokine CCL5', 'Female', 'Gene Expression Regulation, Leukemic', 'Hematopoiesis', 'Hematopoietic Stem Cells', 'Histone-Lysine N-Methyltransferase', 'Leukemia', 'Leukocyte Common Antigens', 'Male', 'Mice, Inbred C57BL', 'Myeloid-Lymphoid Leukemia Protein', 'On... | 30,728,174 | [['G07.345.124'], ['B01.050'], ['B01.050.050.282'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D12.644.276.374.200.110.250', 'D12.776.467.374.200.110.250', 'D23.125.300.110.250', 'D23.469.200.110.250', 'D23.529.374.200.110.250'], ['G05.308.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association of the polymorphisms 292 C>T and 1304 G>A in the SLC38A4 gene with hyperglycaemia. | BACKGROUND: The SLC38A4 gene is related to system 'A' activity, which seems to be related to impaired gluconeogenesis. The objective of this study was to determine whether the 292 C>T and 1304 G>A polymorphisms of SLC38A4 gene are associated with hyperglycaemia in humans.METHODS: A total of 227 individuals were enrolle... | ['Adult', 'Aged', 'Alleles', 'Amino Acid Transport System A', 'Body Mass Index', 'Case-Control Studies', 'Female', 'Gene Frequency', 'Genetic Association Studies', 'Genetic Predisposition to Disease', 'Genotype', 'Haplotypes', 'Humans', 'Hyperglycemia', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide'] | 22,945,694 | [['M01.060.116'], ['M01.060.116.100'], ['G05.360.340.024.340.030'], ['D12.776.157.530.200.500.100', 'D12.776.543.585.200.500.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G05.330'], ['... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Solid-state NMR studies of biomineralization peptides and proteins. | Nature has evolved sophisticated strategies for engineering hard tissues through the interaction of proteins, and ultimately cells, with inorganic mineral phases. This process, called biomineralization, is how living organisms transform inorganic materials such as hydroxyapatite, calcite, and silica into highly intrica... | ['Calcium Carbonate', 'Durapatite', 'Humans', 'Magnetic Resonance Spectroscopy', 'Microscopy, Electron, Scanning', 'Models, Molecular', 'Peptides', 'Proteins', 'Salivary Proteins and Peptides', 'Silicon Dioxide'] | 23,932,180 | [['D01.146.275', 'D01.200.275.150.150', 'D01.578.200'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['E05.599.59... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of adipose-derived mesenchymal stem cell transplantation on cyclophosphamide-induced ovarian damage in rats]. | OBJECTIVE: To explore the effect of adipose-derived mesenchymal stem cells (ADMSCs) on ovarian damage induced by cyclophosphamide (CTX) and its mechanism.
Methods: ADMSCs isolated from adipose tissue of female SD rats were cultured and divided into a blank group and a CTX group (n=15 in each group). CTX (75 mg/kg) was... | ['Animals', 'Cyclophosphamide', 'Female', 'Mesenchymal Stem Cells', 'Ovary', 'Quality of Life', 'Rats', 'Rats, Sprague-Dawley'] | 31,413,210 | [['B01.050'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['A11.329.830.500', 'A11.872.590.500'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Mutant species of EF-Tu, altered at position 375, exhibit a reduced affinity for aminoacylated transfer-RNAs. | The interaction between EF-Tu X GTP and aminoacyl-tRNA is shown to be influenced by mutations at site 375 of this three-domain protein. Site 375 is located in domain II near the interface with domain I [(1984) EMBO J. 3, 113-120]. Replacement of the alanine at this site by a threonine or valine residue results in lower... | ['Amino Acid Sequence', 'Escherichia coli', 'Guanosine Triphosphate', 'Hydrolysis', 'Kinetics', 'Mutation', 'Peptide Elongation Factor Tu', 'Peptide Elongation Factors', 'RNA, Transfer, Amino Acyl', 'Structure-Activity Relationship'] | 3,888,672 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D03.633.100.759.646.454.504', 'D13.695.667.454.504', 'D13.695.827.426.504'], ['G02.380'], ['G01.374.661', 'G02.111.490'], ['G05.365.590'], ['D08.811.277.040.330.300.100.700', 'D12.776.157.325.150.700', 'D12.776.835.70... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Docetaxel (Taxotere) in advanced renal cell cancer. A phase II trial of the EORTC Early Clinical Trials Group. | Docetaxel (Taxotere), an analogue of paclitaxel, was tested in a phase II study in advanced renal cell carcinoma. Consenting patients with measurable lesions, adequate organ functions and no prior chemotherapy received 100 mg/m2 of docetaxel as a 1-h infusion every 3 weeks. No premedication to avoid hypersensitivity re... | ['Adult', 'Aged', 'Antineoplastic Agents, Phytogenic', 'Carcinoma, Renal Cell', 'Docetaxel', 'Female', 'Humans', 'Kidney Neoplasms', 'Male', 'Middle Aged', 'Paclitaxel', 'Taxoids'] | 7,654,430 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248.179'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['D02.455.426.392.368.242.888.389', 'D02.455.849.291.850.389'], ['B01.050.150.900.649.313.988.400.11... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Procalcitonin is a valuable prognostic marker in cardiac surgery but not specific for infection. | BACKGROUND: The prognostic value of elevated serum levels of procalcitonin (PCT) in patients early after cardiac surgery on cardiopulmonary bypass (CPB) remains unclear. In a prospective study, we investigated whether PCT is useful as a prognostic marker in cardiac surgery with respect to mortality, complications and i... | ['Aged', 'Biomarkers', 'Calcitonin', 'Calcitonin Gene-Related Peptide', 'Cardiac Surgical Procedures', 'Cardiopulmonary Bypass', 'Female', 'Glycoproteins', 'Humans', 'Male', 'Mediastinitis', 'Multiple Organ Failure', 'Pneumonia', 'Prognosis', 'Prospective Studies', 'Protein Precursors', 'Sensitivity and Specificity', '... | 14,669,128 | [['M01.060.116.100'], ['D23.101'], ['D06.472.699.150', 'D06.472.931.052', 'D12.644.400.095', 'D12.644.548.150', 'D12.776.631.650.095'], ['D12.644.400.097', 'D12.776.631.650.097'], ['E04.100.376', 'E04.928.220'], ['E04.292.413'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.846.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The evaluation of a semiautomated computer method to determine the effects of DMSO on Giardia lamblia-intestinal cell interaction. | In this work, we describe a semiautomated computer method to evaluate the activity of a common drug solvent, dimethyl sulfoxide (DMSO), on in vitro Giardia lamblia-host cell interaction. To compare the number of intestinal cells (IEC-6) and the adhered trophozoites over a specific area in control and treated coculture,... | ['Animals', 'Automation', 'Cell Adhesion', 'Cell Line', 'Dimethyl Sulfoxide', 'Epithelial Cells', 'Giardia lamblia', 'Image Processing, Computer-Assisted', 'Microscopy, Video', 'Rats', 'Solvents'] | 17,659,385 | [['B01.050'], ['J01.897.104'], ['G04.022'], ['A11.251.210'], ['D02.886.640.150'], ['A11.436'], ['B01.237.385.400'], ['L01.224.308'], ['E01.370.350.515.690', 'E05.595.690', 'J01.897.280.500.898.475', 'L01.178.820.090.898.475', 'L01.178.847.823.475'], ['B01.050.150.900.649.313.992.635.505.700'], ['D27.720.844']] | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Evaluation of the effects of 17beta-estradiol (17beta-e2) on gene expression in experimental autoimmune encephalomyelitis using DNA microarray. | The aim of this study was to identify immune-related genes affected by treatment with 17beta-estradiol (17beta-E2) that contribute to protection of T cell antigen receptor double transgenic mice from experimental autoimmune encephalomyelitis (EAE). The Affymetrix microarray system was used to screen more than 12,000 ge... | ['Animals', 'Encephalomyelitis, Autoimmune, Experimental', 'Estradiol', 'Female', "Freund's Adjuvant", 'Gene Expression', 'Mice', 'Mice, Transgenic', 'Nuclease Protection Assays', 'Oligonucleotide Array Sequence Analysis', 'Ribonucleases'] | 11,751,623 | [['B01.050'], ['C10.114.703.300', 'C10.228.140.695.562.250', 'C10.314.350.250', 'C20.111.258.625.300', 'E05.598.500.500.500'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D20.475'], ['G05.297'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.8... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CSF shunt infections in children. | The incidence of shunt infections and possible risk factors was investigated by chart analysis. From 1986 to 1989 350 shunt procedures were performed including 273 ventriculoperitoneal shunts and 75 ventriculoatrial shunts. Twenty-eight infectious episodes (8%) occurred in 25 patients during a median follow-up time of ... | ['Adolescent', 'Anti-Bacterial Agents', 'Cerebrospinal Fluid Shunts', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Gram-Negative Bacterial Infections', 'Gram-Positive Bacterial Infections', 'Heart Atria', 'Humans', 'Hydrocephalus', 'Infant', 'Infant, Newborn', 'Male', 'Recurrence', 'Reoperation', 'Risk ... | 8,491,526 | [['M01.060.057'], ['D27.505.954.122.085'], ['E04.035.188', 'E04.525.170'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C01.150.252.400'], ['C01.150.252.410'], ['A07.541.358'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.22... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of playing video games on perceptions of one's humanity. | According to self-perception theory, individuals infer their characteristics by observing their own behavior. In the present research, the hypothesis is examined whether helping behavior increases perceptions of one's own humanity even when help is given that does not benefit a real person. In fact, two studies reveale... | ['Adult', 'Aggression', 'Dehumanization', 'Female', 'Helping Behavior', 'Humans', 'Male', 'Play and Playthings', 'Self Concept', 'Video Games', 'Violence'] | 23,951,954 | [['M01.060.116'], ['F01.145.126.125', 'F01.145.813.045'], ['F01.145.813.191'], ['F01.145.813.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.450.642.693'], ['F01.752.747.792'], ['I03.450.642.693.930', 'L01.224.900.930'], ['I01.198.240.856', 'I01.880.735.900']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 |
Polycaprolactone electrospun fiber scaffold loaded with iPSCs-NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury. | Background: Spinal cord injury (SCI) is a traumatic disease of the central nervous system, accompanied with high incidence and high disability rate. Tissue engineering scaffold can be used as therapeutic systems to provide effective repair for SCI.Purpose: In this study, a novel tissue engineering scaffold has been syn... | ['Animals', 'Axons', 'Behavior, Animal', 'Cell Separation', 'Coculture Techniques', 'Fetal Blood', 'Induced Pluripotent Stem Cells', 'Leukocytes, Mononuclear', 'Mice', 'Nerve Growth Factors', 'Neural Stem Cells', 'Polyesters', 'Rats, Wistar', 'Schwann Cells', 'Spinal Cord', 'Spinal Cord Injuries', 'Tissue Engineering',... | 30,349,249 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['F01.145.113'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['E05.481.500.374'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['A11.872.040.500', 'A11.872.700.500'], ['A11.118.637.555', 'A15.145.229.637.555', '... | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A comparative study of copper ion induced lysis of vertebrate red blood cells. | 1. Erythrocytes from different vertebrate classes were tested for susceptibility towards copper ion-induced lysis under identical copper ion concentration and per cent cell volumes. 2. The susceptibility towards lysis was found to be correlated with the rate of copper ion entry into the erythrocytes. 3. GSH levels decl... | ['Animals', 'Copper', 'Glutathione', 'Hemolysis', 'Humans', 'Species Specificity', 'Vertebrates'] | 2,905,946 | [['B01.050'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D12.644.456.448'], ['C23.550.403', 'G12.122.545'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G16.824'], ['B01.050.150.900']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of cytomegalovirus viremia on subclinical rejection or interstitial fibrosis and tubular atrophy in protocol biopsy at 3 months in renal allograft recipients managed by preemptive therapy or antiviral prophylaxis. | BACKGROUND: Cytomegalovirus (CMV) is a risk factor for acute renal allograft rejection. The aim of this study was to determine the impact of CMV viremia on subclinical rejection (SCR) and interstitial fibrosis and tubular atrophy (IF/TA) in protocol biopsy at 3 months after transplantation.METHODS: A total of 118 conse... | ['Adult', 'Antiviral Agents', 'Atrophy', 'Biopsy', 'Cyclosporine', 'Cytomegalovirus Infections', 'Female', 'Fibrosis', 'Follow-Up Studies', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Kidney Tubules', 'Male', 'Middle Aged', 'Patient Selection', 'Retrospective Studies', 'Risk Factors', 'Survival Ana... | 19,202,451 | [['M01.060.116'], ['D27.505.954.122.388'], ['C23.300.070'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['C01.925.256.466.245'], ['C23.550.355'], ['E05.318.372.500.750.249',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
cDNA cloning, characterization, expression and recombinant protein production of leukemia inhibitory factor (LIF) from the marsupial, the brushtail possum (Trichosurus vulpecula). | A reverse transcription technique using RNA templates combined with polymerase chain reaction (RT-PCR) was used to clone the cDNA fragment encoding the amino acid sequence of mature LIF protein of the marsupial, the brushtail possum, Trichosurus vulpecula. A PCR product with expected size, of 546bp, and termed tvLIF, w... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cloning, Molecular', 'DNA, Complementary', 'Female', 'Gene Expression', 'Glutathione Transferase', 'Growth Inhibitors', 'Interleukin-6', 'Leukemia Inhibitory Factor', 'Lymphokines', 'Molecular Sequence Data', 'Opossums', 'Pregnancy', 'Protein Conformation', 'RNA, Mes... | 10,675,625 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.297'], ['D08.811.913.225.500'], ['D27.505.696.377.450'], ['D12.644.276.374.465.224', 'D12.776.467.374... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Aberrant course of the intracranial facial nerve in cases of atresia of the internal auditory canal (IAC). | INTRODUCTION: The aim of this study is to describe the morphology of the rare malformation that is atresia of the internal auditory canal (IAC) and determine the course of the facial nerve in cases of normal facial nerve function.METHODS: Index cases were retrospectively selected from our electronic database in which a... | ['Child, Preschool', 'Ear, Inner', 'Facial Nerve', 'Facial Paralysis', 'Female', 'Hearing Loss, Sensorineural', 'Humans', 'Infant', 'Magnetic Resonance Imaging', 'Male', 'Retrospective Studies', 'Tomography, X-Ray Computed'] | 21,448,638 | [['M01.060.406.448'], ['A09.246.300'], ['A08.800.050.050.275', 'A08.800.050.600.149', 'A08.800.800.060.275', 'A08.800.800.120.250'], ['C07.465.327', 'C10.597.622.214', 'C23.888.592.636.214'], ['C09.218.458.341.887', 'C10.597.751.418.341.887', 'C23.888.592.763.393.341.887'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Endogenous GABA acts on GABAB receptors in nucleus tractus solitarius to increase blood pressure. | Previous studies found that injection of the GABA uptake inhibitor nipecotic acid into the nucleus tractus solitarius (NTS) increases arterial pressure. This effect of nipecotic acid was not antagonized by the selective GABAA receptor blocking agent bicuculline, suggesting that the action of nipecotic acid was mediated... | ['4-Aminobutyrate Transaminase', 'Aminocaproates', 'Animals', 'Baclofen', 'Blood Pressure', 'GABA Antagonists', 'GABA-A Receptor Antagonists', 'Male', 'Medulla Oblongata', 'Muscimol', 'Nipecotic Acids', 'Proline', 'Rats', 'Rats, Inbred Strains', 'Receptors, GABA-A', 'Vigabatrin', 'gamma-Aminobutyric Acid'] | 2,175,240 | [['D08.811.913.477.700.200'], ['D02.241.081.193.150', 'D12.125.213'], ['B01.050'], ['D02.241.081.114.500.350.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D27.505.519.625.240.300', 'D27.505.696.577.240.300'], ['D27.505.519.625.240.300.500', 'D27.505.696.577.240.300.500'], ['A08.186.211.132.810.591.500'], ['D03.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cyclin-dependent kinase 5 activity regulates pain signaling. | Several molecules and cellular pathways have been implicated in nociceptive signaling, but their precise molecular mechanisms have not been clearly defined. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase implicated in the development and disease of the mammalian nervous system. The preci... | ['Animals', 'Calpain', 'Cells, Cultured', 'Cyclin-Dependent Kinase 5', 'Female', 'Ganglia, Spinal', 'Hot Temperature', 'Inflammation', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Mice, Transgenic', 'Nerve Fibers', 'Nociceptors', 'Pain', 'Phosphotransferases', 'Rats', 'Rats, Sprague-Dawley', 'Signal Transdu... | 16,407,116 | [['B01.050'], ['D08.811.277.656.262.500.120', 'D08.811.277.656.300.200.120'], ['A11.251'], ['D08.811.913.696.620.682.700.646.500.500.500', 'D12.644.360.250.067.875', 'D12.776.167.200.067.875', 'D12.776.476.250.067.875'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['G01.906.595.543', 'G16.500.275... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Tissue basophils of the thyroid gland in separate and combined exposure to ionizing radiation and ethanol]. | Experiments with male albino rats gave evidence that a single intraperitoneal injection of 15% ethanol at the doses of 0.28 and 2.25 g/kg resulted in enhanced elimination of biologically active substances by tissue basophils (TB) both due to intensified degranulation and greater number of TB in the thyroid gland. Singl... | ['Animals', 'Basophil Degranulation Test', 'Ethanol', 'Injections, Intraperitoneal', 'Male', 'Mast Cells', 'Radiation Dosage', 'Radiation, Ionizing', 'Rats', 'Thyroid Gland'] | 9,244,505 | [['B01.050'], ['E01.370.225.812.100', 'E05.200.812.100', 'E05.478.594.100'], ['D02.033.375'], ['E02.319.267.530.490'], ['A11.329.427', 'A15.382.652'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['G01.750.750'], ['B01.050.150.900.649.313.992.635.505.700'], ['A06.300.900']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Binge eating and binge-eating disorder in Black women: A systematic review. | OBJECTIVE: Although several effective behavioral treatments for binge-eating disorder (BED) exist, there are racial disparities in treatment access, with African-Americans and/or Black individuals having some of the lowest rates of access to care. Little is known about the experience and treatment of binge eating (BE) ... | ['African Americans', 'Binge-Eating Disorder', 'Female', 'Humans', 'Male'] | 31,922,293 | [['M01.686.508.100.100', 'M01.686.754.100'], ['F03.400.188'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Mutual dependence of calcitonin-gene related peptide and acetylcholine release in neuromuscular preparations. | To investigate the mutual dependence of calcitonin gene-related peptide (CGRP) and acetylcholine release, we examined the effect of a cholinesterase inhibitor neostigmine on the release of CGRP-like immunoreactivity in rat phrenic nerve-hemidiaphragm muscle preparation, and conversely, the effect of CGRP on [3H]acetylc... | ['Acetylcholine', 'Animals', 'Calcitonin Gene-Related Peptide', 'Cholinesterase Inhibitors', 'Diaphragm', 'Electric Stimulation', 'Male', 'Mice', 'Mice, Inbred Strains', 'Motor Neurons', 'Muscle, Skeletal', 'Neostigmine', 'Neuromuscular Junction', 'Phrenic Nerve', 'Radioimmunoassay', 'Rats', 'Rats, Wistar'] | 9,253,944 | [['D02.092.211.111'], ['B01.050'], ['D12.644.400.097', 'D12.776.631.650.097'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['A02.633.567.900.300'], ['E05.723.402'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Loss of expression of ì-protocadherin and protocadherin-24 in sporadic and hereditary nonpolyposis colorectal cancers. | Colorectal cancer (CRC) is a neoplastic disease in which normal mucosa undergoes a process of malignant transformation due to the progressive accumulation of molecular alterations affecting proto-oncogenes and oncosuppressor genes. Some of these modifications exert their carcinogenic potential by promoting a constituti... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Cadherins', 'Colorectal Neoplasms', 'Colorectal Neoplasms, Hereditary Nonpolyposis', 'Female', 'Humans', 'Male', 'Middle Aged'] | 30,296,522 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['C04.588.274.47... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Percutaneous drainage of abscesses in the postoperative abdomen that is difficult to explore. | We have evaluated our experience with computerized tomography and ultrasonography guided percutaneous drainage of extrahepatic abdominal fluid collections in a group of 22 patients. The most common goal was to avoid or delay surgery on abdomens in which reoperation would be difficult, mainly in high-risk patients. Drai... | ['Abdomen', 'Abscess', 'Drainage', 'Humans', 'Pancreatic Diseases', 'Postoperative Care', 'Postoperative Complications', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 3,887,956 | [['A01.923.047'], ['C01.830.025', 'C23.550.470.756.100'], ['E02.309', 'E04.237'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.689'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.722.700'], ['C23.550.767'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.8... | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. | To identify previously unknown platelet receptors we compared the transcriptomes of in vitro differentiated megakaryocytes (MKs) and erythroblasts (EBs). RNA was obtained from purified, biologically paired MK and EB cultures and compared using cDNA microarrays. Bioinformatical analysis of MK-up-regulated genes identifi... | ['Cell Differentiation', 'Erythroblasts', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Humans', 'Megakaryocytes', 'Oligonucleotide Array Sequence Analysis', 'Platelet Membrane Glycoproteins'] | 17,192,395 | [['G04.152'], ['A11.148.378.590.837.250.200', 'A11.443.240.497.200', 'A15.378.316.378.590.837.250.200'], ['E05.393.332'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.148.479', 'A15.378.316.479'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['D12.776.395.550.625', 'D... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effects of oxidative stress on ventricular remodeling after myocardial infarction in rats]. | OBJECTIVE: To investigate the effects of oxidative stress on ventricular remodeling after acute myocardial infarction (AMI) in rats.METHODS: AMI was induced in 20 SD rats by ligation of the anterior descending coronary artery, and another 12 rats without the ligation served as the sham-operated group. Six weeks after t... | ['Animals', 'Antioxidants', 'Male', 'Malondialdehyde', 'Myocardial Infarction', 'Myocardium', 'Oxidative Stress', 'Random Allocation', 'Rats', 'Rats, Sprague-Dawley', 'Superoxide Dismutase', 'Ventricular Remodeling'] | 19,033,120 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D02.047.700'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['G03.673', 'G07.775.750'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Say Yes First: follow up of a five-year rural drug prevention program. | Say Yes First--To Rural Youth and Family Alcohol/Drug Prevention (SYF) was a 5-year, federally-funded U.S.D.H.H.S. Center for Substance Abuse Prevention (CSAP) project that involved 859 children in the class of the year 2000. The children in four rural school districts were followed from Grade 4 to Grade 8 from 1991 to... | ['Child', 'Child Health Services', 'Colorado', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Outcome Assessment, Health Care', 'Prevalence', 'Rural Health Services', 'School Health Services', 'Students', 'Substance-Related Disorders', 'Surveys and Questionnaires'] | 15,468,749 | [['M01.060.406'], ['N02.421.143.130'], ['Z01.107.567.875.760.210'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['E05.318.308.985.525.750', 'N01.224.935.597.... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Tuberlatum coatsi gen. n., sp. n. (Alveolata, Perkinsozoa), a New Parasitoid with Short Germ Tubes Infecting Marine Dinoflagellates. | Perkinsozoa is an exclusively parasitic group within the alveolates and infections have been reported from various organisms, including marine shellfish, marine dinoflagellates, freshwater cryptophytes, and tadpoles. Despite its high abundance and great genetic diversity revealed by recent environmental rDNA sequencing... | ['Alveolata', 'Dinoflagellida', 'Microscopy, Electron, Scanning', 'Microscopy, Electron, Transmission', 'Phylogeny', 'RNA, Algal', 'RNA, Protozoan', 'Republic of Korea', 'Sequence Analysis, RNA'] | 30,797,136 | [['B01.043'], ['B01.043.214'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.130'], ['D13.444.735.650'], ['Z01.252.474.557.750'], ['E05.393.760.710']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Evolutionary mechanisms and population dynamics of the third variable envelope region of HIV within single hosts. | Clonal diversifications of HIV virus were monitored by periodic samplings on each of the six patients with regard to 183- to 335-bp segments of the env gene, which invariably included the functionally critical V3 region. Subsequently, six individual phylogenetic trees of viral variants were constructed. It was found th... | ['Amino Acid Sequence', 'Evolution, Molecular', 'Genes, env', 'Genetic Variation', 'HIV', 'HIV Envelope Protein gp120', 'HIV Infections', 'Humans', 'Molecular Sequence Data', 'Mutagenesis', 'Peptide Fragments', 'Phylogeny', 'Population Dynamics', 'Selection, Genetic', 'Sequence Analysis', 'Time Factors'] | 9,037,041 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.024.340.364.875.172', 'G05.360.340.358.024.875.172', 'G05.360.340.358.840.500.172'], ['G05.365'], ['B04.820.650.589.650.350'], ['D12.776.964.775.325.164.249', 'D12.776.964.775.562.500.500', 'D12.776.964.970.880.325.164.249', 'D23... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Metabolic disposition of N,N-dibenzyldaunorubicin in the rat. | The more efficacious and less cardiotoxic analogue of daunorubicin, N,N-dibenzyldaunorubicin (B2D), was found to be metabolized in rats by stepwise debenzylation that was superimposed on the known anthracycline metabolism via 13-ketone reduction and deglycosidation. Using high-pressure liquid chromatography for resolut... | ['Animals', 'Chromatography, High Pressure Liquid', 'Daunorubicin', 'Female', 'Kinetics', 'Liver', 'Lung', 'Muscles', 'Myocardium', 'Rats', 'Rats, Inbred Strains', 'Tissue Distribution'] | 6,831,396 | [['B01.050'], ['E05.196.181.400.300'], ['D02.455.426.559.847.562.050.200', 'D04.615.562.050.200', 'D09.408.051.059.200'], ['G01.374.661', 'G02.111.490'], ['A03.620'], ['A04.411'], ['A02.633', 'A10.690'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.52... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Aspects of family structure, psychosocial stress and economic achievement: a cross cultural comparison]. | For the European countries data giving insight into the situation of the family have been collected on a very broad basis. Data for 4 cross-sections in the period 1950 to 1970 are investigated. Comparing indicators for the family situation with data for socio-psychological stress (suicide rates, criminality and murder ... | ['Achievement', 'Cross-Cultural Comparison', 'Family', 'Humans', 'Motivation', 'Social Environment', 'Socioeconomic Factors', 'Stress, Psychological'] | 7,415,373 | [['F01.658.059', 'F02.784.629.054'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658', 'F01.752.543.500.750'], ['I01.880.853.500'], ['I01.880.853.996', 'N01.824'], ['F01.145.126.990', 'F02.830.900']] | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Estimation of lumbar spinal loading and trunk muscle forces during asymmetric lifting tasks: application of whole-body musculoskeletal modelling in OpenSim. | Large spinal compressive force combined with axial torsional shear force during asymmetric lifting tasks is highly associated with lower back injury (LBI). The aim of this study was to estimate lumbar spinal loading and muscle forces during symmetric lifting (SL) and asymmetric lifting (AL) tasks using a whole-body mus... | ['Back Injuries', 'Back Muscles', 'Biomechanical Phenomena', 'Healthy Volunteers', 'Humans', 'Lifting', 'Lumbar Vertebrae', 'Male', 'Psoas Muscles', 'Risk Factors', 'Task Performance and Analysis', 'Weight-Bearing', 'Young Adult'] | 27,194,401 | [['C26.117'], ['A02.633.567.175'], ['G01.154.090', 'G01.374.089'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.669'], ['A02.835.232.834.519'], ['A02.633.567.825'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A restraint system for the common marmoset (Callithrix jacchus). | A method for restraining the marmoset in a primate chair is described. The device is inexpensive to construct, is reliable, and the majority of animals can be habituated to its use. The chair has been used in neurobiological studies employing electrophysiological recordings, with or without concurrent collection of ser... | ['Animals', 'Blood Specimen Collection', 'Callithrix', 'Callitrichinae', 'Electrophysiology', 'Restraint, Physical'] | 3,134,573 | [['B01.050'], ['E01.370.225.998.110', 'E04.665.150', 'E05.200.998.110'], ['B01.050.150.900.649.313.988.400.600.150.150.114'], ['B01.050.150.900.649.313.988.400.600.150.150'], ['H01.158.344.528', 'H01.158.782.236'], ['E02.085.700', 'E05.472.760']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Ambulatory monitoring of blood pressure in growth hormone-deficient adults. | The aim of this study was to evaluate the 24-h pattern of blood pressure in adults with growth hormone deficiency using ambulatory blood pressure monitoring. We therefore evaluated the mean systolic and diastolic blood pressures, systolic and diastolic blood pressure loads and diurnal blood pressure rhythm. We used an ... | ['Adult', 'Blood Pressure', 'Blood Pressure Monitoring, Ambulatory', 'Circadian Rhythm', 'Diastole', 'Female', 'Growth Disorders', 'Human Growth Hormone', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Regression Analysis', 'Systole'] | 12,048,425 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140.100', 'E01.370.520.500.100'], ['G07.180.562.190'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['C23.550.393'], ['D06.472.699.631.525.425.875', 'D12.644.548.691.525.425.875'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Intrapopulation niche partitioning in a generalist predator limits food web connectivity. | Predators are increasingly recognized as key elements in food webs because of their ability to link the fluxes of nutrients and energy between spatially separated food chains. However, in the context of food web connectivity, predator populations have been mainly treated as homogeneous units, despite compelling evidenc... | ['Animals', 'Food Chain', 'Liver', 'Muscle, Skeletal', 'Perches', 'Population Dynamics', 'Predatory Behavior'] | 19,739,388 | [['B01.050'], ['G16.500.275.157.250', 'N06.230.124.250'], ['A03.620'], ['A02.633.567', 'A10.690.552.500'], ['B01.050.150.900.493.602.600'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['F01.145.113.111.600', 'F01.145.113.252.520']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Expression of transferrin receptors is unrelated to proliferative status in cultured human colon cancer cells. | Transferrin is an iron-carrying compound that stimulates cell growth and division by binding to specific receptors (TR) which are preferentially expressed by actively growing cells or by the malignant counterpart of normal cells. However, quiescent cells may not necessarily cease expressing TR. We evaluated TR expressi... | ['Antibodies, Monoclonal', 'Cell Division', 'Cells, Cultured', 'Colonic Neoplasms', 'Humans', 'Receptors, Transferrin', 'Transferrin'] | 3,592,625 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage. | OBJECTIVE: To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA) pathophysiological process in the cartilage.METHODS: We performed RNA sequencing in 130 samples (n=35 and n=30 pairs for messenger RNA (mRNA) and miRNA, respectively) on macroscopically preserved and lesioned OA cartilage from the same pa... | ['Cartilage, Articular', 'Computational Biology', 'Humans', 'MicroRNAs', 'Osteoarthritis', 'RNA, Messenger', 'Sequence Analysis, RNA'] | 30,504,444 | [['A02.165.407.150', 'A02.835.583.192'], ['H01.158.273.180', 'L01.313.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['C05.550.114.606', 'C05.799.613'], ['D13.444.735.544'], ['E05.393.760.710']] | ['Anatomy [A]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Which definition to use when defining airflow obstruction?]. | INTRODUCTION: There is no clear consensus as to what constitutes an obstructive ventilatory defect (OVD). According to the American Thoracic Society and European Respiratory Society, it is defined as being when the ratio of the forced expiratory volume (FEV1) and the slow expiratory vital capacity (VC) is below the low... | ['Cross-Sectional Studies', 'Humans', 'Lung Diseases, Obstructive', 'Lung Volume Measurements', 'Male', 'Middle Aged', 'Plethysmography', 'Smoking', 'Societies, Medical', 'Surveys and Questionnaires'] | 17,417,170 | [['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.495'], ['E01.370.386.700.485'], ['M01.060.116.630'], ['E01.370.370.610'], ['F01.145.805'], ['N03.540.828.589'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
IL-4, IL-10 and IL-13 modulate A beta(1--42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line. | A hallmark of the immunopathology associated with Alzheimer's disease (AD) is the presence of activated microglia surrounding senile plaque deposits of beta-amyloid (A beta) peptides. A beta peptides have been shown to be potent activators of microglia and macrophages, but little is known about endogenous factors that ... | ['Alzheimer Disease', 'Amyloid beta-Peptides', 'Animals', 'Cell Line', 'Chemokine CCL2', 'Dose-Response Relationship, Drug', 'Gene Expression', 'Humans', 'Interleukin-1', 'Interleukin-10', 'Interleukin-13', 'Interleukin-4', 'Interleukin-6', 'Interleukins', 'Lipopolysaccharides', 'Mice', 'Mice, Inbred Strains', 'Microgl... | 11,137,576 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['A11.251.210'], ['D12.644.276.374.200.110.990.600', 'D12.776.467.374.200.110.990.600', 'D23.125.300.110.990.600', 'D23.469.200.110.990.600', 'D23.529.374.200.110.990.500'], ['... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
"Man-ing" up and getting drunk: the role of masculine norms, alcohol intoxication and alcohol-related problems among college men. | Compared to college women, college men face elevated risks for problematic drinking and negative alcohol-related consequences. These risks highlight the critical need to investigate gender issues and risk factors contributing to intoxication and related problems among men. Theoretical models suggest that conforming to ... | ['Alcohol Drinking', 'Alcoholic Intoxication', 'California', 'Cross-Sectional Studies', 'Humans', 'Male', 'Masculinity', 'Peer Group', 'Risk Factors', 'Social Conformity', 'Surveys and Questionnaires', 'Universities', 'Young Adult'] | 21,620,570 | [['F01.145.317.269'], ['C25.775.100.175', 'F03.900.100.300'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.813.376', 'F01.393.446.250.750', 'F01.752.747.385.200.750'], ['F... | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Rate constant of muscle force redevelopment reflects cooperative activation as well as cross-bridge kinetics. | The rate of muscle force redevelopment after release-restretch protocols has previously been interpreted using a simple two-state cross-bridge cycling model with rate constants for transitions between non-force-bearing and force-bearing states, f, and between force-bearing and non-force-bearing states, g. Changes in th... | ['Animals', 'Calcium', 'Heart', 'Kinetics', 'Models, Biological', 'Muscle Contraction', 'Muscle, Skeletal', 'Myocardial Contraction'] | 8,994,610 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A07.541'], ['G01.374.661', 'G02.111.490'], ['E05.599.395'], ['G11.427.494'], ['A02.633.567', 'A10.690.552.500'], ['G09.330.580', 'G11.427.494.570']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Different response to amine fluoride by Streptococcus mutans and polymicrobial biofilms in a novel high-throughput active attachment model. | BACKGROUND/AIMS: The antimicrobial resistance of microorganisms in biofilms and the polymicrobial interactions in these biofilms that modulate resistance require novel strategies to evaluate the efficacy of caries-preventive compounds. The current study aimed to evaluate the effects of a caries-preventive agent in Stre... | ['Bacterial Adhesion', 'Biofilms', 'Cariostatic Agents', 'Colony Count, Microbial', 'Dental Research', 'Fluorides, Topical', 'Microbial Interactions', 'Streptococcus mutans'] | 20,668,379 | [['G06.099.050'], ['A20.593', 'G06.120'], ['D25.223', 'D27.505.696.706.222', 'D27.720.102.223', 'D27.720.799.113', 'J01.637.051.223'], ['E01.370.225.875.220', 'E05.200.875.220'], ['H01.770.644.145.124', 'H02.163.090'], ['D01.303.350.300.512', 'D25.223.432', 'J01.637.051.223.432'], ['G06.550'], ['B03.353.750.737.872.875... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Cumulative health risk assessment of 17 perfluoroalkylated and polyfluoroalkylated substances (PFASs) in the Swedish population. | Humans are simultaneously exposed to a multitude of chemicals. Human health risk assessment of chemicals is, however, normally performed on single substances, which may underestimate the total risk, thus bringing a need for reliable methods to assess the risk of combined exposure to multiple chemicals. Per- and polyflu... | ['Animals', 'Environmental Exposure', 'Environmental Monitoring', 'Environmental Pollutants', 'Environmental Pollution', 'Fish Products', 'Fishes', 'Food Contamination', 'Hazardous Substances', 'Health', 'Humans', 'Hydrocarbons, Fluorinated', 'Immune System', 'Liver', 'Mammary Glands, Human', 'Occupational Exposure', '... | 23,792,420 | [['B01.050'], ['N06.850.460.350'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.888.284'], ['N06.850.460'], ['G07.203.300.600.875.400', 'J02.500.600.875.400'], ['B01.050.150.900.493'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['D27.888.426'], ['N01.400'], ['B01.050.150.900.649.313... | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Comparison of malaria incidence rates and socioeconomic-environmental factors between the states of Acre and Rond?nia: a spatio-temporal modelling study. | BACKGROUND: Plasmodium falciparum malaria is a threat to public health, but Plasmodium vivax malaria is most prevalent in Latin America, where the incidence rate has been increasing since 2016, particularly in Venezuela and Brazil. The Brazilian Amazon reported 193,000 cases in 2017, which were mostly confirmed as P. v... | ['Brazil', 'Environment', 'Humans', 'Incidence', 'Malaria', 'Models, Theoretical', 'Socioeconomic Factors', 'Spatio-Temporal Analysis'] | 31,484,519 | [['Z01.107.757.176'], ['G16.500.275', 'N06.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C01.610.752.530', 'C01.920.875'], ['E05.599'], ['I01.880.853.996', 'N01.824'], ['E05.318.740.933.500', 'N... | ['Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Changes in the process of care for Medicaid patients with schizophrenia in Utah's Prepaid Mental Health Plan. | OBJECTIVE: Changes in the process of psychiatric care received by Medicaid beneficiaries with schizophrenia were examined after the introduction of capitated payments for enrollees of some community mental health centers (CMHCs) under the Utah Prepaid Mental Health Plan.METHODS: Data from the medical records of 200 pat... | ['Adult', 'Capitation Fee', 'Case Management', 'Community Mental Health Centers', 'Continuity of Patient Care', 'Fee-for-Service Plans', 'Humans', 'Medicaid', 'Medication Errors', 'Mental Health Services', 'Office Visits', 'Prepaid Health Plans', 'Process Assessment, Health Care', 'Program Evaluation', 'Psychotropic Dr... | 9,550,244 | [['M01.060.116'], ['N03.219.442.090'], ['N04.590.233.624.250'], ['N02.278.035.158'], ['E02.760.169', 'N02.421.585.169', 'N04.590.233.727.210'], ['N03.219.442.195', 'N03.219.521.710.305.090', 'N04.452.758.745.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.346.506.564.655', 'N03.706.615.693'], ['E0... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The majority of animal genes are required for wild-type fitness. | Almost all eukaryotic genes are conserved, suggesting that they have essential functions. However, only a minority of genes have detectable loss-of-function phenotypes in experimental assays, and multiple theories have been proposed to explain this discrepancy. Here, we use RNA-mediated interference in C. elegans to ex... | ['Animals', 'Caenorhabditis elegans', 'Escherichia coli', 'Gene Regulatory Networks', 'Genetic Fitness', 'Phenotype', 'RNA Interference'] | 22,341,449 | [['B01.050'], ['B01.050.500.500.294.400.875.660.250.250'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.080.689.360'], ['G05.347'], ['G05.695'], ['G05.308.203.374.790']] | ['Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Search and selection methodology of systematic reviews in orthodontics (2000-2004). | INTRODUCTION: More systematic reviews related to orthodontic topics are published each year, although little has been done to evaluate their search and selection methodologies.METHODS: Systematic reviews related to orthodontics published between January 1, 2000, and December 31, 2004, were searched for their use of mul... | ['Databases, Bibliographic', 'Dental Informatics', 'Humans', 'Information Storage and Retrieval', 'Meta-Analysis as Topic', 'Orthodontics', 'Review Literature as Topic'] | 16,905,066 | [['L01.313.500.750.300.188.300', 'L01.470.750.500'], ['L01.313.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.313.500.750.280', 'L01.470'], ['E05.318.370.500', 'E05.581.500.501', 'N05.715.360.325.515', 'N06.850.520.445.500'], ['E06.658', 'H02.163.876.439'], ['L01.178.682.759']] | ['Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Natural history of adult-onset idiopathic torticollis. | The rates of spontaneous remission and progression of dystonia to other sites were studied in 72 patients who first presented with adult-onset torticollis, and who were followed up for a mean of 7.7 years. Dystonia had progressed to sites other than the neck (mainly the face and upper limbs) in 23 patients (32%). The l... | ['Adult', 'Discriminant Analysis', 'Dystonia', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Remission, Spontaneous', 'Torticollis'] | 2,334,302 | [['M01.060.116'], ['E05.318.740.350', 'N05.715.360.750.325', 'N06.850.520.830.350'], ['C10.597.350.300', 'C23.888.592.350.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['C23.550.291.656.700', 'G16.767'], ['C23.888.592.350.300.800']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The fetal recoil test. | A reassuring fetal recoil test has positive and negative predictive values of 98% and 8%, respectively, for a reactive nonstress test (sensitivity 89%, specificity 33%). Among 21 of 30 subjects in whom recoil was present immediately before delivery, none had umbilical arterial pH values < or = 7.20 versus 5 of 9 (56%) ... | ['Acoustic Stimulation', 'Female', 'Fetal Monitoring', 'Fetal Movement', 'Humans', 'Predictive Value of Tests', 'Pregnancy', 'Reflex, Startle', 'Sensitivity and Specificity'] | 1,442,995 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['E01.370.378.230', 'E01.370.520.230'], ['G07.345.500.325.235.374', 'G08.686.784.170.157.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['G08.686.784.769'], ['E01.370.376.550.650.800',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Biaryl amide glucagon receptor antagonists. | Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge. | ['Amides', 'Animals', 'Haplorhini', 'Humans', 'Mice', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Glucagon'] | 15,080,976 | [['D02.065'], ['B01.050'], ['B01.050.150.900.649.313.988.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D12.776.543.750.695.330', 'D12.776.543.750.750.580.350']] | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of high and normal soyprotein breakfasts on satiety and subsequent energy intake, including amino acid and 'satiety' hormone responses. | BACKGROUND: The role of dietary protein in short term satiety is of interest with respect to body weight regulation.AIM: To compare the effects of a high versus a normal soyprotein breakfast on satiety and subsequent energy intake (EI), including 'satiety' hormones and plasma amino acid responses.METHODS: Twenty-five h... | ['Adult', 'Amino Acids', 'Blood Glucose', 'Dietary Proteins', 'Energy Intake', 'Female', 'Ghrelin', 'Glucagon-Like Peptide 1', 'Hormones', 'Humans', 'Insulin', 'Male', 'Satiation', 'Soybean Proteins', 'Taste Perception', 'Taurine', 'Time Factors'] | 19,142,569 | [['M01.060.116'], ['D12.125'], ['D09.947.875.359.448.500'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G07.203.650.240.340'], ['D06.472.699.301', 'D12.644.548.322'], ['D06.472.317.680.500.500'], ['D06.472', 'D27.505.696.399.472'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.587.200.500.625'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
The epigenetic regulator PLZF represses L1 retrotransposition in germ and progenitor cells. | Germ cells and adult stem cells maintain tissue homeostasis through a finely tuned program of responses to both physiological and stress-related signals. PLZF (Promyelocytic Leukemia Zinc Finger protein), a member of the POK family of transcription factors, acts as an epigenetic regulator of stem cell maintenance in ge... | ["5' Untranslated Regions", 'Animals', 'Cell Differentiation', 'Chromatin Immunoprecipitation', 'DNA Methylation', 'Epigenomics', 'Gene Expression Regulation', 'Germ Cells', 'Kruppel-Like Transcription Factors', 'Long Interspersed Nucleotide Elements', 'Mice', 'Promyelocytic Leukemia Zinc Finger Protein', 'Stem Cells',... | 23,727,884 | [['D13.444.735.544.875.885', 'D13.444.735.790.878.885', 'G05.360.340.024.220.880.885', 'G05.360.340.024.340.137.910.885'], ['B01.050'], ['G04.152'], ['E05.393.170', 'E05.478.605.160'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['H01.158.273.180.350.074', 'H01.158.273.343.350.042'], ['G05.308... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Epidemiological profile of elderly patients with non-melanoma skin cancer seen at the dermatology outpatient clinic of a public hospital. | Basal cell carcinoma and Squamous cell carcinoma, referred to as non-melanoma skin cancer, are the most common malignancies in humans. Their incidence is increasing worldwide every year. In Brazil, even with the advent of educational campaigns on photoprotection and laws that banned tanning beds, they are the most freq... | ['Age Distribution', 'Aged', 'Aged, 80 and over', 'Ambulatory Care Facilities', 'Brazil', 'Carcinoma, Basal Cell', 'Carcinoma, Squamous Cell', 'Comorbidity', 'Female', 'Hospitals, Public', 'Humans', 'Male', 'Middle Aged', 'Sex Distribution', 'Skin Neoplasms'] | 29,364,457 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['N02.278.035'], ['Z01.107.757.176'], ['C04.557.470.200.165', 'C04.557.470.565.165'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['N05.715.350.225', 'N06.850.490.687'], ['N02.278.421.510'], ['B01.050.150.900.649.3... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Traditional neonatal care practices in Turkey. | AIM: The research was conducted as a descriptive and cross-sectional study in order to identify the traditional neonatal care practices applied by women in the 15-49 year age range.METHODS: The research sample comprised 263 married mothers aged 15-49 years living in the seven health center regions in Sivas city center ... | ['Adolescent', 'Adult', 'Cross-Sectional Studies', 'Female', 'Humans', 'Infant, Newborn', 'Medicine, Traditional', 'Middle Aged', 'Neonatal Nursing', 'Turkey', 'Young Adult'] | 23,735,089 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E02.190.488', 'I01.076.201.450.654'], ['M01.060.116.630'], ['H02.478.676.390.600', 'H02.478.676.631.600', 'N02.421.533.460.600', 'N02.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Interaction of corticotropin-releasing factor and glucagon-like peptide-1 on behaviors in chicks. | Both corticortropin-releasing factor (CRF) and glucagon-like peptide-1 (GLP-1) inhibit food intake of chicks, but they also produce other behaviors. The present experiments were undertaken to clarify the interaction of CRF and GLP-1 regarding their anorectic actions as well as other behaviors. In Experiment 1, birds we... | ['Animals', 'Animals, Newborn', 'Brain Chemistry', 'Chickens', 'Corticotropin-Releasing Hormone', 'Drug Interactions', 'Eating', 'Glucagon', 'Glucagon-Like Peptide 1', 'Injections, Intraventricular', 'Locomotion', 'Male', 'Peptide Fragments', 'Protein Precursors', 'Vocalization, Animal'] | 11,698,065 | [['B01.050'], ['B01.050.050.282'], ['G02.111.150', 'G03.185'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D06.472.699.327.740.140', 'D12.644.400.400.740.140', 'D12.644.548.365.740.140', 'D12.776.631.650.405.740.140'], ['G07.690.773.968'], ['G07.203.650.283', 'G10.261.330'], ['D06.472.699.587.730.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Atherosclerotic lesions, myocardial damage and lipidograms: a multiarterial study applying an atherometric system and canonical correlation. | 472 autopsy subjects were examined with the following aims: to study the association pattern of atherosclerotic lesions between different arterial sectors, the impact of serum lipid disorders (total cholesterol, HDL-c, LDL-c, VLDL-c, and triglycerides were analyzed) and the association pattern between the atherosclerot... | ['Arteries', 'Arteriosclerosis', 'Cholesterol', 'Cholesterol, HDL', 'Cholesterol, LDL', 'Cholesterol, VLDL', 'Heart Injuries', 'Humans', 'Lipids', 'Myocardium', 'Triglycerides'] | 9,653,913 | [['A07.015.114'], ['C14.907.137.126'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['D04.210.... | ['Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Laparoscopic Gastric Banding: Game Over? | The laparoscopic adjustable gastric banding (LAGB) procedure has been used in bariatric surgery for over 20 years, and despite its initial success, it has been most often criticized for causing adverse effects, lacking efficacy, and frequently requiring revision. Evidence-based medicine supports these criticisms, and t... | ['Bariatric Surgery', 'Gastroplasty', 'Hospitalization', 'Humans', 'Laparoscopy', 'Obesity, Morbid', 'Reoperation', 'Treatment Outcome', 'Weight Loss'] | 28,488,092 | [['E02.650.500.062', 'E04.062'], ['E02.650.500.062.750', 'E04.062.750', 'E04.210.485'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C18.654.726.500.700', 'C23.888.144.699.500.500', 'E01.370.600.115.100.160.120.699.500.500', 'G07.100.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Focus group study of student physiotherapists' perceptions of reflection. | CONTEXT: The reflective practice module in the physiotherapy programme at the University of Limerick, Ireland represents the first incidence of the inclusion of such a module within physiotherapy curricula in Ireland. However, research examining the contribution of reflection as a means of learning is limited, particul... | ['Attitude of Health Personnel', 'Clinical Competence', 'Curriculum', 'Education, Medical', 'Education, Nursing', 'Female', 'Focus Groups', 'Humans', 'Ireland', 'Male', 'Physical Therapists', 'Self-Assessment', 'Students, Health Occupations'] | 19,141,008 | [['F01.100.050', 'N05.300.100'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.158'], ['I02.358.399'], ['I02.358.462'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.467', 'Z01.639.587'], ['M01.526.485.790', 'N02.360.790'], ['F01... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Mammalian lymphocytes: stress-induced synthesis of heat-shock proteins in vitro and in vivo. | Mammalian (human, mouse, and rabbit) white blood cells (lymphocytes) maintained in culture respond to a brief incubation at an elevated temperature (at or above 41 degrees C) by (i) the new and (or) enhanced synthesis of a small number of proteins (the so-called heat-shock proteins; HSPs) having molecular masses of app... | ['Animals', 'Carbon Radioisotopes', 'Cell Line', 'Fever', 'Heat-Shock Proteins', 'Hot Temperature', 'Humans', 'Leucine', 'Lymphocytes', 'Methionine', 'Mice', 'Mice, Inbred BALB C', 'Molecular Weight', 'Plasmacytoma', 'Rabbits', 'Species Specificity', 'Sulfur Radioisotopes'] | 4,041,967 | [['B01.050'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['A11.251.210'], ['C23.888.119.344'], ['D12.776.580.216'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Critical factors influencing the recovery and integrity of rRNA extracted from environmental samples: use of an optimized protocol to measure depth-related biomass distribution in freshwater sediments. | A protocol was developed for the efficient recovery of intact, high molecular weight rRNA from different environmental matrices. Critical variables were identified in sample processing that influenced yield and integrity of recovered nucleic acid. Most notably, the order of addition and the buffer to sample volume rati... | ['Biomass', 'Buffers', 'Electrophoresis, Polyacrylamide Gel', 'Environmental Microbiology', 'Escherichia coli', 'Fresh Water', 'Genetic Techniques', 'Geologic Sediments', 'Great Lakes Region', 'Guanidines', 'Mercaptoethanol', 'Nucleic Acid Hybridization', 'RNA, Ribosomal', 'Seawater', 'Thiocyanates'] | 10,699,671 | [['G16.500.275.157.100', 'N06.230.124.100'], ['D27.720.470.280'], ['E05.196.401.402', 'E05.301.300.319'], ['H01.158.273.540.274', 'N06.850.425'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G16.500.275.280', 'N06.230.232'], ['E05.393'], ['G01.311.330', 'G16.500.320'], ['Z01.107.567.875.350'], ['D02.078.37... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Contribution of the renin-angiotensin system to short-term blood pressure variability during blockade of nitric oxide synthesis in the rat. | 1. The aim of this study was to investigate, by use of spectral analysis, (1) the blood pressure (BP) variability changes in the conscious rat during blockade of nitric oxide (NO) synthesis by the L-arginine analogue NG-nitro-L-arginine methyl ester (L-NAME); (2) the involvement of the renin-angiotensin system in these... | ['Animals', 'Biphenyl Compounds', 'Blood Pressure', 'Heart Rate', 'Imidazoles', 'Losartan', 'Male', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Rats', 'Rats, Wistar', 'Renin-Angiotensin System', 'Tetrazoles'] | 8,937,709 | [['B01.050'], ['D02.455.426.559.389.185'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.875.500', 'G09.330.380.500'], ['D03.383.129.308'], ['D02.455.426.559.389.185.475', 'D03.383.129.308.507', 'D03.383.129.617.467'], ['D12.125.068.050.525', 'D12.125.095.104.525'], ['D01.339.387', 'D01.625.550.500', 'D01.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Social performance and secret ritual: battling against obsessive-compulsive disorder. | This autoethnography offers an account of my experience with mental illness and provides an analysis of the performative aspects of obsessive-compulsive disorder (OCD). OCD is a genetic disorder triggered by environmental stressors involving a chemical imbalance in the brain. The resulting biologically altered state le... | ['Adaptation, Psychological', 'Anthropology, Cultural', 'Autobiographies as Topic', 'Ceremonial Behavior', 'Communication', 'Humans', 'Interpersonal Relations', 'Mental Health', 'Obsessive-Compulsive Disorder', 'Patient Acceptance of Health Care', 'Qualitative Research', 'Social Identification', 'Stress, Psychological'... | 20,739,588 | [['F01.058'], ['I01.076.201'], ['K01.517.211.215'], ['F01.145.813.097', 'I01.076.201.450.170'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F02.418', 'N01.400.500'], ['F03.080.600'], ['F01.100.150.750.500', 'F01.145.488.887.500', 'N05.300.150.800.500'], ['H01.770.644.... | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
Neonatal intensive care nursery staff perceive enhanced workplace quality with the single-family room design. | OBJECTIVE: To compare perceived workplace quality in an open-bay neonatal intensive care unit (NICU) and a single-family room (SFR) NICU.STUDY DESIGN: Prospective non-randomized, non-controlled cohort study.RESULT: Staff workplace quality perceptions assessed included the following: the quality of being a Sanford Healt... | ['Adult', 'Attitude of Health Personnel', 'Cohort Studies', 'Facility Design and Construction', 'Family Nursing', 'Female', 'Health Care Surveys', 'Humans', 'Infant, Newborn', 'Intensive Care Units, Neonatal', 'Job Satisfaction', 'Male', 'Nurseries, Hospital', 'Nursing Staff, Hospital', "Patients' Rooms", 'Young Adult'... | 19,798,047 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['J01.086.339', 'N02.278.200'], ['H02.478.676.218'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 |
Patterns of PD-L1 expression and CD8 T cell infiltration in gastric adenocarcinomas and associated immune stroma. | OBJECTIVE: Recent data supports a significant role for immune checkpoint inhibitors in the treatment of solid tumours. Here, we evaluate gastric and gastro-oesophageal junction (G/GEJ) adenocarcinomas for their expression of programmed death-ligand 1 (PD-L1), infiltration by CD8+ T cells and the relationship of both fa... | ['Adenocarcinoma', 'Adult', 'Aged', 'Aged, 80 and over', 'B7-H1 Antigen', 'CD8-Positive T-Lymphocytes', 'DNA, Viral', 'Disease-Free Survival', 'Esophagogastric Junction', 'Female', 'Herpesvirus 4, Human', 'Humans', 'Lymphocytes, Tumor-Infiltrating', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Stomach Neoplasms', '... | 26,801,886 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.465.625', 'D12.776.467.150.300', 'D12.776.543.095.300', 'D23.050.301.285.400', 'D23.529.168.300'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['D13.444.308.568'], ['... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Excess of serum copper not related to ceruloplasmin in Alzheimer disease. | OBJECTIVE: To assess the role of serum copper in relation to ceruloplasmin and other peripheral markers of inflammation in Alzheimer disease (AD).METHODS: The authors studied serum levels of copper, ceruloplasmin, and transferrin, as well as total peroxides, antioxidants, and other peripheral markers of inflammation in... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Antioxidants', 'Biomarkers', 'Ceruloplasmin', 'Copper', 'Encephalitis', 'Female', 'Humans', 'Inflammation Mediators', 'Male', 'Middle Aged', 'Peroxides', 'Predictive Value of Tests', 'Transferrin'] | 15,781,823 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D23.101'], ['D08.811.682.226', 'D12.776.124.050.130', 'D12.776.124.790.106.214', 'D12.776.157.160', 'D12.776.377.715.085.214', 'D12.776.556.151']... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis. | BACKGROUND: Patients with acute myeloid leukemia (AML) with hyperleukocytosis of at least 100 x 10(9) per L are at high risk of early death due to pulmonary or cerebral leukostasis. Although the efficacy of leukapheresis in terms of prompt cytoreduction is generally accepted, published data regarding the clinical value... | ['Adult', 'Aged', 'Female', 'Hemoglobins', 'Humans', 'Leukapheresis', 'Leukemia, Myeloid', 'Leukemia, Myeloid, Acute', 'Leukocyte Count', 'Leukocytosis', 'Male', 'Middle Aged', 'Prognosis', 'Retrospective Studies', 'Survival Analysis', 'Treatment Outcome'] | 17,880,610 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.160.570', 'E02.120.285.570', 'E02.120.527.570', 'E05.200.500.363.171.570', 'E05.242.363.171.570'], ['C04.557.337.539'], ['C04.557.337.539.275'], ['E01.370.225.500.195.107.595', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Exposure-related effects on Cd bioaccumulation explain toxicity of Cd-phenanthrene mixtures in Hyalella azteca. | Little is known regarding mixture effects of metals and polynuclear aromatic hydrocarbon (PAHs) under environmentally relevant exposure regimes. Standard U.S. Environmental Protection Agency (U.S. EPA) procedures were applied and extended to test effects of phenanthrene (Phen) on sediment-Cd uptake, aqueous-Cd uptake, ... | ['Amphipoda', 'Animals', 'Cadmium', 'Kinetics', 'Phenanthrenes', 'Water'] | 16,398,129 | [['B01.050.500.131.365.055'], ['B01.050'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['G01.374.661', 'G02.111.490'], ['D02.455.426.559.847.723', 'D04.615.723'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Limitations to basal and insulin-stimulated skeletal muscle glucose uptake in the high-fat-fed rat. | Rats fed a high-fat diet display blunted insulin-stimulated skeletal muscle glucose uptake. It is not clear whether this is due solely to a defect in glucose transport, or if glucose delivery and phosphorylation are also impaired. To determine this, rats were fed standard chow (control rats) or a high-fat diet (HF rats... | ['3-O-Methylglucose', 'Animals', 'Arteries', 'Biological Transport', 'Blood Glucose', 'Body Water', 'Carbon Radioisotopes', 'Dietary Fats', 'Fatty Acids, Nonesterified', 'Glucose', 'Hyperinsulinism', 'Insulin', 'Male', 'Mannitol', 'Muscle, Skeletal', 'Phosphorylation', 'Rats', 'Rats, Sprague-Dawley', 'Tritium'] | 11,052,961 | [['D09.408.348.500.500', 'D09.408.514.622.500'], ['B01.050'], ['A07.015.114'], ['G03.143'], ['D09.947.875.359.448.500'], ['A12.207.200'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D10.251.310'], ['D09.947.875.359.448'], ['C18.452.394.968'], ['D06... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
New tools for Mendelian disease gene identification: PhenoDB variant analysis module; and GeneMatcher, a web-based tool for linking investigators with an interest in the same gene. | Identifying the causative variant from among the thousands identified by whole-exome sequencing or whole-genome sequencing is a formidable challenge. To make this process as efficient and flexible as possible, we have developed a Variant Analysis Module coupled to our previously described Web-based phenotype intake too... | ['Computational Biology', 'Databases, Genetic', 'Genetic Association Studies', 'Genetic Diseases, Inborn', 'Genetic Variation', 'Genomics', 'Internet', 'Phenotype', 'Software', 'Web Browser'] | 25,684,268 | [['H01.158.273.180', 'L01.313.124'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['E05.393.385'], ['C16.320'], ['G05.365'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['L01.224.230.110.500'], ['G05.695'], ['L01.224.900'], ['L01.224.900.940', 'L01.470.937']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
The effect of pre-adsorption of OVA or WPC on subsequent OVA or WPC fouling on heated stainless steel surface. | Fouling on the heat exchanger surface during food processing has been researched extensively due to its great importance in energy efficiency, product quality and food safety. The nature of heat exchanger surface has an effect on the initial deposition behavior and deposit removal behavior to some degree. Protein adsor... | ['Adsorption', 'Animals', 'Biofouling', 'Chickens', 'Hot Temperature', 'Hydrophobic and Hydrophilic Interactions', 'Ovalbumin', 'Stainless Steel', 'Surface Properties', 'Temperature', 'Whey Proteins'] | 25,863,709 | [['G01.030', 'G02.020'], ['B01.050'], ['G16.500.100', 'N06.850.460.150', 'N06.850.540.500'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['G02.409'], ['D12.644.861... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
The changing incidence of oesophageal and gastric adenocarcinoma by anatomic sub-site. | BACKGROUND: The incidence rates of gastric and oesophageal adenocarcinoma are changing significantly, but little is known about specific sub-sites.AIM: To use a population-based approach to describe the trends in the site-specific incidence of oesophageal and gastric adenocarcinoma.METHODS: Using the Rochester Epidemio... | ['Adenocarcinoma', 'Aged', 'Aged, 80 and over', 'Esophageal Neoplasms', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Minnesota', 'Stomach Neoplasms'] | 17,270,000 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Stiff skin syndrome and myeloma successfully treated with autologous haematopoietic stem cell transplantation (HSCT). | Stiff skin syndrome (SSS) is a rare scleroderma-like syndrome characterised by stone hard skin, joint limitation and progressive restriction of chest that may lead to death. We describe the efficacy of haematopoietic autologous stem cell transplantation (HSCT) in a case of SSS secondary to a smouldering myeloma (SM), w... | ['Contracture', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Skin Diseases, Genetic', 'Transplantation, Autologous', 'Treatment Outcome'] | 23,910,622 | [['C05.550.323', 'C05.651.197'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.595.500', 'C14.907.454.460', 'C15.378.147.780.650', 'C15.378.463.515.460', 'C20.683.515.845', 'C20.683.780.650'], ['C16.320.850', 'C17.800.827'], ['E04.936... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[New aspects of early gastric carcinoma]. | Between 1st January 1970 and 31st December 1984, 910 total or subtotal resections for gastric cancer were carried out in the Department of Surgery of the University Clinic Mannheim. A work-up of operative specimens showed that 146 patients (16%) had early gastric carcinoma. The patients comprised 97 men and 49 women; t... | ['Adenocarcinoma', 'Adult', 'Age Factors', 'Aged', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Sex Factors', 'Stomach', 'Stomach Neoplasms'] | 3,948,718 | [['C04.557.470.200.025'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['N05.715.350.675', 'N06.850.490.875'], ['A03.556.875.875'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.7... | ['Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Is p53 a protein that predicts the response to chemotherapy in node negative breast cancer? | The role of p53 in modulating apoptosis has suggested that it may affect efficacy of anti cancer agents. For this reason, we have evaluated p53 alterations in 282 consecutive patients with infiltrating node-negative breast cancer who underwent primary surgery and were randomized either to CMF (Cyclophosphamide 400 mg/m... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Breast Neoplasms', 'Cyclophosphamide', 'Female', 'Fluorouracil', 'Humans', 'Lymphatic Metastasis', 'Methotrexate', 'Middle Aged', 'Tumor Suppressor Protein p53'] | 9,493,975 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.180', 'C17.800.090.500'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['D03.383.742.698.875.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['D03.63... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Patient time costs associated with sensor-augmented insulin pump therapy for type 1 diabetes: results from the STAR 3 randomized trial. | BACKGROUND: Sensor-augmented pump therapy (SAPT) leads to lower glycated hemoglobin levels than multiple daily injections of insulin (MDI) in patients with type 1 diabetes. Patient time and costs associated with SAPT are not known.OBJECTIVE: We compared time spent on diabetes-related care, changes in time, and associat... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Diabetes Mellitus, Type 1', 'Health Care Costs', 'Humans', 'Infusion Pumps', 'Insulin', 'Middle Aged', 'Time and Motion Studies', 'Young Adult'] | 23,128,579 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.505', 'E07.858.082.505'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['M01.060.1... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Skin and coat traits in sheep in Brazil and their relation with heat tolerance. | The objective of this study was to evaluate and compare physical parameters in groups of sheep with different phenotypic characteristics in the Centre-west region of Brazil. Five groups of sheep, with nine animals per group, were selected, three groups of Santa In?s animals with different coat colours (white, brown and... | ['Acclimatization', 'Animals', 'Brazil', 'Hair', 'Hot Temperature', 'Linear Models', 'Phenotype', 'Pigmentation', 'Sheep', 'Skin', 'Skin Pigmentation', 'Species Specificity', 'Sweat Glands'] | 20,680,445 | [['G07.025.133', 'G16.012.500.133'], ['B01.050'], ['Z01.107.757.176'], ['A17.360'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.7... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Traumatic experiences and posttraumatic stress reactions in children and their parents from Kurdistan and Sweden. | This study was conducted to assess trauma scores and posttraumatic stress symptoms among Kurdistanian refugee children and their parents in Sweden and a comparable group of Swedish children and their parents. Comparative Kurdistanian and Swedish samples composed of 32 children each and their parents were interviewed by... | ['Adolescent', 'Adult', 'Child', 'Female', 'Humans', 'Male', 'Middle East', 'Parents', 'Psychiatric Status Rating Scales', 'Refugees', 'Stress Disorders, Post-Traumatic', 'Stress, Psychological', 'Sweden'] | 11,839,132 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620'], ['F04.711.513.653'], ['M01.755'], ['F03.950.750.500'], ['F01.145.126.990', 'F02.830.900'], ['Z01.542.816.500']] | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
[Relationship between the state of the autonomic nervous system and nociceptive reactivity during preoperative emotional stress]. | Using a complex of techniques, the state of autonomic nervous system, nociceptive reactivity, emotional status and endocrine reactions have been studied in 108 patients with preoperative emotional stress. It has been established that the immediate preoperative period in young patients is characterized by predominance o... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Autonomic Nervous System', 'Female', 'Humans', 'Male', 'Middle Aged', 'Models, Biological', 'Pain Measurement', 'Stress, Psychological', 'Surgical Procedures, Operative'] | 7,943,897 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A08.800.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.599.395'], ['E01.370.600.550.324'], ['F01.145.126.990', 'F02.830.900'], ['E04']] | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Dimerization of cGMP-dependent protein kinase Ibeta is mediated by an extensive amino-terminal leucine zipper motif, and dimerization modulates enzyme function. | All mammalian cGMP-dependent protein kinases (PKGs) are dimeric. Dimerization of PKGs involves sequences located near the amino termini, which contain a conserved, extended leucine zipper motif. In PKG Ibeta this includes eight Leu/Ile heptad repeats, and in the present study, deletion and site-directed mutagenesis hav... | ['Amino Acid Motifs', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Blotting, Western', 'Cell Line', 'Centrifugation, Density Gradient', 'Chromatography, Gel', 'Cyclic GMP', 'Cyclic GMP-Dependent Protein Kinase Type I', 'Cyclic GMP-Dependent Protein Kinases', 'Dimerization', 'Dose-Response Relationship, Drug', 'E... | 12,933,804 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210'], ['E05.181.724.336', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Hidradenitis suppurativa: epidemiological study of cases diagnosed at a dermatological reference center in the city of Bauru, in the Brazilian southeast State of S?o Paulo, between 2005 and 2015. | Background:: Hidradenitis is a chronic inflammatory disease of the hair follicles. A treatment is necessary due to chronicity and psychological changes that patient present.Objective:: To investigate epidemiological aspects and elaborate a risk group profile, promote early diagnosis and contribute to the knowledge abou... | ['Adolescent', 'Adult', 'Brazil', 'Child', 'Cross-Sectional Studies', 'Female', 'Hidradenitis Suppurativa', 'Humans', 'Male', 'Middle Aged', 'Prevalence', 'Retrospective Studies', 'Risk Factors', 'Sex Distribution', 'Young Adult'] | 28,538,878 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.757.176'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C01.150.252.819.420', 'C01.800.720.420', 'C01.830.499', 'C17.800.838.765.420', 'C17.800.946.315.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Differential inhibitory effects of sulfated polysaccharides and polymers on the replication of various myxoviruses and retroviruses, depending on the composition of the target amino acid sequences of the viral envelope glycoproteins. | Sulfated polysaccharides (i.e., dextran sulfate) and sulfated polymers (i.e., sulfated polyvinylalcohol and sulfated copolymers of acrylic acid with vinylalcohol) were found to be potent and selective inhibitors of the replication of respiratory syncytial virus (RSV) and influenza virus type A (influenza A virus) but n... | ['Acrylic Resins', 'Amino Acid Sequence', 'Dextran Sulfate', 'Heparin', 'Microbial Sensitivity Tests', 'Molecular Sequence Data', 'Orthomyxoviridae', 'Pentosan Sulfuric Polyester', 'Retroviridae', 'Virus Replication'] | 1,725,692 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D09.698.365.272.300'], ['D09.698.373.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['L01.453.245.667'], ['B04.820.480.968'], ['D02.886.645.655.424', 'D09.698.682'], ['B04... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Osteoporosis Recognition in Rats under Low-Power Lens Based on Convexity Optimization Feature Fusion. | Considering the poor medical conditions in some regions of China, this paper attempts to develop a simple and easy way to extract and process the bone features of blurry medical images and improve the diagnosis accuracy of osteoporosis as much as possible. After reviewing the previous studies on osteoporosis, especiall... | ['Algorithms', 'Animals', 'Disease Models, Animal', 'Female', 'Image Interpretation, Computer-Assisted', 'Lenses', 'Microscopy', 'Osteoporosis', 'Random Allocation', 'Rats, Sprague-Dawley', 'Sensitivity and Specificity', 'Tibia', 'Tomography, X-Ray Computed'] | 31,358,772 | [['G17.035', 'L01.224.050'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E07.632.500'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['C05.116.198.579', 'C18.452.104.579'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
L-uridine: synthesis and behavior as enzyme substrate. | L-Uridine, the enantiomer of the normal RNA constituent D-uridine, was synthesized from L-ribose through coupling with bis(trimethylsilyl)-uracil. The synthetic product had the expected chemical and physical characteristics. When used as the acceptor for phosphate transfer by the nucleoside phosphotransferase of carrot... | ['Nucleotidyltransferases', 'Phosphotransferases', 'Ribose', 'Spectrophotometry', 'Stereoisomerism', 'Uridine'] | 5,260,923 | [['D08.811.913.696.445'], ['D08.811.913.696'], ['D09.947.875.627.651'], ['E05.196.712.726', 'E05.196.867.826'], ['G02.607.445.682'], ['D03.383.742.680.852', 'D13.570.685.852', 'D13.570.800.892']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Hsp70 Gene Family in Solanum tuberosum: Genome-Wide Identification, Phylogeny, and Expression Patterns. | Heat shock protein 70 (Hsp70) family members play important roles in protecting plants against abiotic stresses, including salt, drought, heat, and cold. In this study, 20 putative StHsp70 genes were identified in potato (Solanum tuberosum L.) through the integration of the gene structures, chromosome locations, phylog... | ['Chromosomes, Plant', 'Gene Expression Profiling', 'Gene Expression Regulation, Plant', 'Genome, Plant', 'HSP70 Heat-Shock Proteins', 'Multigene Family', 'Phylogeny', 'Plant Proteins', 'Solanum tuberosum', 'Stress, Physiological'] | 30,413,778 | [['A11.284.187.560', 'A18.005', 'G05.360.162.560'], ['E05.393.332'], ['G05.308.375'], ['G05.360.340.365'], ['D12.776.580.216.375'], ['G05.360.340.024.340.645'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D12.776.765'], ['B01.650.940.800.575.912.250.908.500.725.777'], ['G07.775']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[In vitro inhibition of Chlamydia trachomatis growth by liposome-encapsulated cyclines]. | The antichlamydial activity of tetracycline (Tet) and doxycycline (Dox) encapsulated in cationic (CaL), anionic (AnL) and neutral (NtL) liposomes has been evaluated in vitro by adding serial dilutions of antibiotics (minimum inhibitory concentration, MIC: 0.12-0.007 microgram/ml; MBC: 4 to 0.25 micrograms/ml) to HeLa 2... | ['Anti-Bacterial Agents', 'Chlamydia trachomatis', 'Doxycycline', 'Liposomes', 'Tetracycline'] | 11,265,224 | [['D27.505.954.122.085'], ['B03.440.190.190.190.750'], ['D02.455.426.559.847.562.900.200', 'D04.615.562.900.200'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['D02.455.426.559.847.562.900.875', 'D04.615.562.900.875']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Acute myocardial infarction--multivessel coronary artery disease in a 37-year-old postpartum women]. | Acute myocardial infarction (MI) in the postpartum period is rare. We present a case of a 37-year-old women with acute MI which occurred 15 days after delivery. Coronary angiography revealed multivessel coronary artery disease and she underwent successful surgical revascularisation. | ['Adult', 'Coronary Angiography', 'Coronary Artery Bypass', 'Coronary Artery Disease', 'Female', 'Humans', 'Myocardial Infarction', 'Puerperal Disorders'] | 20,054,771 | [['M01.060.116'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.647... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison and agreement between the Richmond Agitation-Sedation Scale and the Riker Sedation-Agitation Scale in evaluating patients' eligibility for delirium assessment in the ICU. | BACKGROUND: Delirium evaluation in patients in the ICU requires the use of an arousal/sedation assessment tool prior to assessing consciousness. The Richmond Agitation-Sedation Scale (RASS) and the Riker Sedation-Agitation Scale (SAS) are well-validated arousal/sedation tools. We sought to assess the concordance of RAS... | ['Adult', 'Aged', 'Cohort Studies', 'Consciousness', 'Delirium', 'Diagnostic Techniques and Procedures', 'Female', 'Humans', 'Hypnotics and Sedatives', 'Indiana', 'Intensive Care Units', 'Male', 'Mass Screening', 'Middle Aged', 'Outcome Assessment, Health Care', 'Prospective Studies', 'Psychomotor Agitation', 'Retrospe... | 22,539,644 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['F02.463.188.409', 'F02.830.233'], ['C10.597.606.337.500', 'C23.888.592.604.339.500', 'F01.700.250.500', 'F03.615.350'], ['E01.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.277.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Mortality in alcoholics with autonomic neuropathy. | Seventy-nine male chronic alcoholics who had been tested for autonomic neuropathy using four tests of vagus nerve function were followed for up to 7 years (mean 5.5 years). Thirty-two subjects had no vagal neuropathy, 25 had one abnormal test and 22 had two or more abnormal vagal function tests and two of these also ha... | ['Adult', 'Aged', 'Alcoholism', 'Autonomic Nervous System Diseases', 'Cause of Death', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Risk Factors', 'Vagus Nerve'] | 3,379,420 | [['M01.060.116'], ['M01.060.116.100'], ['C25.775.100.250', 'F03.900.100.350'], ['C10.177'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.3... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Seroprevalence of Mycobacterium avium subsp paratuberculosis infection among dairy cows in Colorado and herd-level risk factors for seropositivity. | OBJECTIVE: To estimate seroprevalence of Mycobacterium avium subsp paratuberculosis (MAP) infection among adult dairy cows in Colorado and determine herd-level factors associated with the risk that individual cows would be seropositive.DESIGN: Cross-sectional observational study.ANIMALS: 10,280 adult (> or = 2 years ol... | ['Animals', 'Antibodies, Bacterial', 'Cattle', 'Cattle Diseases', 'Colorado', 'Cross-Sectional Studies', 'Enzyme-Linked Immunosorbent Assay', 'Feces', 'Female', 'Mycobacterium avium subsp. paratuberculosis', 'Paratuberculosis', 'Population Density', 'Risk Factors', 'Seroepidemiologic Studies'] | 15,239,481 | [['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['Z01.107.567.875.760.210'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Pancreatic adenocarcinoma patients with localised chronic severe pancreatitis show an increased number of single beta cells, without alterations in fractional insulin area. | AIMS/HYPOTHESIS: Recent histological analysis of pancreases obtained from patients with long-standing type 1 diabetes identified chronic islet inflammation and limited evidence suggestive of beta cell replication. Studies in rodent models also suggest that beta cell replication can be induced by certain inflammatory cy... | ['Adenocarcinoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Autopsy', 'Cell Nucleus', 'Female', 'Humans', 'Immunohistochemistry', 'Insulin', 'Insulin-Secreting Cells', 'Ki-67 Antigen', 'Male', 'Middle Aged', 'Pancreatic Neoplasms', 'Pancreatitis, Chronic', 'Reference Values', 'Young Adult'] | 19,002,428 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', '... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
Essential thrombocythemia and recurrent myocardial infarction. | We report the case of recurrent myocardial infarction with essential thrombocythemia (ET) in a 61-year-old female patient. Only one report of recurrence of myocardial infarction has been previously described. Coronary angiography 10 days after the infarction was normal. Thrombocythemia had been controlled with hydroxyu... | ['Angina, Unstable', 'Female', 'Humans', 'Hydroxyurea', 'Middle Aged', 'Myocardial Infarction', 'Platelet Count', 'Recurrence', 'Thrombocythemia, Essential'] | 10,931,165 | [['C14.280.647.187.150', 'C14.907.585.187.150', 'C23.888.592.612.233.500.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.065.950.395'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['E01.370.225.500.195.107.740', 'E01.370.225.625.107.700', 'E01... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
TTC7A mutations disrupt intestinal epithelial apicobasal polarity. | Multiple intestinal atresia (MIA) is a rare cause of bowel obstruction that is sometimes associated with a combined immunodeficiency (CID), leading to increased susceptibility to infections. The factors underlying this rare disease are poorly understood. We characterized the immunological and intestinal features of 6 u... | ['Base Sequence', 'Cell Polarity', 'Cells, Cultured', 'Child', 'Consanguinity', 'DNA Mutational Analysis', 'Epithelial Cells', 'Exome', 'Female', 'Genetic Association Studies', 'Genetic Linkage', 'Humans', 'Infant', 'Intestinal Atresia', 'Intestinal Mucosa', 'Lymph Nodes', 'Lymphopenia', 'Male', 'Pedigree', 'Proteins',... | 24,292,712 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.250'], ['A11.251'], ['M01.060.406'], ['G05.090.403.180', 'G05.180'], ['E05.393.760.700.300'], ['A11.436'], ['G05.360.340.011'], ['E05.393.385'], ['G05.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C06.198.719', 'C06.405.469.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
[Level of DNA fragmentation in human sperm cells in varicocele and prostatitis]. | Varicocele and prostatitis are the most common andrological diseases, which may be accompanied by a decrease in the production of sperm cells, the deterioration of their quality and increased risk of infertility. This work was aimed to the evaluation of sperm DNA fragmentation index (DFI) and main indices of sperm fert... | ['Adult', 'DNA Fragmentation', 'Humans', 'Infertility, Male', 'Male', 'Prostatitis', 'Sperm Count', 'Sperm Motility', 'Spermatozoa', 'Varicocele'] | 25,211,925 | [['M01.060.116'], ['G05.200.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['C12.294.565.750'], ['E01.370.225.500.195.870', 'E01.370.225.992.624', 'E05.200.500.195.870', 'E05.200.992.624', 'E05.242.195.870', 'G04.140.870'], ['E01.370.225.992.812', 'E05.200.992.812', 'G04.198.750'], ['A05.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Adenylate cyclase activity of normal and transformed fibroblasts in culture. | The intracellular concentration of cyclic AMP regulates many cellular properties of normal rat, mouse, and human fibroblasts in culture. Thus it is important to elucidate how the activity of adenylate cyclase of fibroblasts might be altered and regulated by both intracellular and extracellular agents and events. In stu... | ['Adenylyl Cyclase Inhibitors', 'Adenylyl Cyclases', 'Animals', 'Cations, Divalent', 'Cell Division', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Cholera Toxin', 'Enzyme Activation', 'Fatty Acids, Nonesterified', 'Guanine Nucleotides', 'Hormones', 'Humans', 'Mice', 'Models, Biological', 'Phospholipids', 'Rat... | 748,758 | [['D27.505.519.389.108'], ['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['D01.248.497.300.333'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['D08.811.913.400.725.115.180', 'D23.946.123.194', 'D23.946.33... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Codon usage in histone gene families of higher eukaryotes reflects functional rather than phylogenetic relationships. | The nucleic acid sequences coding for 23 H3 histone genes from a variety of species have been analyzed using a computer assisted alignment and analysis program. Although these histones are highly conserved within and between highly divergent species, they represent various classes of histones whose patterns of expressi... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Codon', 'Genes', 'Histones', 'Humans', 'Models, Genetic', 'Phylogeny', 'RNA, Messenger', 'Species Specificity'] | 3,100,813 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['G05.360.340.024.340'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['B01.050.150.900.649.313.988.400.11... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Developmental changes in the engagement of episodic retrieval processes and their relationship with working memory during the period of middle childhood. | We examined the development of children's engagement of the episodic retrieval processes of recollection and familiarity and their relationship with working memory (WM). Ninety-six children (24 in four groups aged 8, 9, 10, and 11 years) and 24 adults performed an episodic memory (EM) task involving old/new, remember/k... | ['Adult', 'Age Factors', 'Analysis of Variance', 'Child', 'Child Development', 'Female', 'Humans', 'Judgment', 'Male', 'Memory, Episodic', 'Memory, Short-Term', 'Recognition, Psychology', 'Task Performance and Analysis', 'Verbal Learning'] | 21,995,741 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.785.626'], ['F02.463.425.540.254'], ['F02.463.425.540.407'], ['F02.463.425.540.706'... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Treating those who fail to take themselves seriously: pathological aspects of humor. | A method of analyzing humor was presented. Patients are first made aware of their "being amused" by bringing their smiling and laughing to their attention. They can be then be led to see that their external life situation has predisposed them to experience an intrapsychic event--the spontaneous emergence of antithetica... | ['Adaptation, Psychological', 'Adult', 'Affect', 'Defense Mechanisms', 'Humans', 'Laughter', 'Myocardial Infarction', 'Personality Development', 'Professional-Patient Relations', 'Psychotherapy', 'Self Concept', 'Smiling', 'Wit and Humor as Topic'] | 2,221,214 | [['F01.058'], ['M01.060.116'], ['F01.470.047'], ['F01.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.530.614'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['F01.752.747'], ['F01.829.401.650', 'N05.300.660'], ['F04.754'], ['F01.752.747.792'], ['F01.145.20... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Alternative splicing of a Caenorhabditis elegans gene produces two novel inhibitory amino acid receptor subunits with identical ligand binding domains but different ion channels. | Two full-length cDNAs, gbr-2A and gbr-2B, encoding inhibitory amino acid receptor subunits have been amplified and cloned from Caenorhabditis elegans mRNA. The 5' 732 bp of the two cDNAs, encoding 237 amino acids, are identical. The 3' 758 bp of the gbr-2B cDNA are present within the 3' untranslated region of the gbr-2... | ['Adaptor Proteins, Signal Transducing', 'Alternative Splicing', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Binding Sites', 'Caenorhabditis elegans', 'Chloride Channels', 'Cloning, Molecular', 'DNA, Helminth', 'GRB2 Adaptor Protein', 'Genes, Helminth', 'Ion Channels', 'Ligands', 'Molecular Sequence Data', 'Pro... | 9,409,779 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
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