Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pneumococcal mastoiditis in children and the emergence of multidrug-resistant serotype 19A isolates. | OBJECTIVE: We review the impact of pneumococcal conjugate vaccine on pneumococcal mastoiditis in children at Texas Children's Hospital.METHODS: The medical charts (including the number of pneumococcal conjugate vaccine doses) for children with pneumococcal mastoiditis treated at Texas Children's Hospital between Januar... | ['Child', 'Child, Preschool', 'Drug Resistance, Bacterial', 'Electrophoresis, Gel, Pulsed-Field', 'Female', 'Humans', 'Infant', 'Male', 'Mastoiditis', 'Microbial Sensitivity Tests', 'Pneumococcal Infections', 'Pneumococcal Vaccines', 'Retrospective Studies', 'Serotyping', 'Streptococcus pneumoniae', 'Temporal Bone', 'T... | 18,595,984 | [['M01.060.406'], ['M01.060.406.448'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['E05.196.401.220', 'E05.301.300.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C01.160.495.500', 'C05.116.165.495.249', 'C09.218.705.663.652'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Artepillin C, as a PPARã ligand, enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. | The nuclear receptor peroxisome proliferator-activated receptor (PPAR) ã plays an important role in adipocyte differentiation. Its ligands, including thiazolidinediones, improve insulin sensitivity in type 2 diabetes. We investigated the effects of artepillin C, an ingredient of Baccharis dracunculifolia, on adipogenes... | ['3T3-L1 Cells', 'Adipocytes', 'Animals', 'Base Sequence', 'Cell Differentiation', 'DNA Primers', 'Dose-Response Relationship, Drug', 'Glucose', 'Insulin', 'Ligands', 'Mice', 'PPAR gamma', 'Phenylpropionates', 'Polymerase Chain Reaction', 'Tumor Necrosis Factor-alpha'] | 21,219,874 | [['A11.251.210.100.775.800', 'A11.329.228.100.775.800'], ['A11.329.114'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.152'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G07.690.773.875', 'G07.690.936.500'], ['D09.947.875.359.448'], ['D06.472.699.587.200.500.625', 'D12... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Tranilast reduces serum IL-6 and IL-13 and protects against thioacetamide-induced acute liver injury and hepatic encephalopathy. | Hepatic encephalopathy is a serious neuropsychiatric disorder usually affecting either acute or chronic hepatic failure patients. Hepatic encephalopathy was replicated in a validated rat model to assess the potential protective efficacy of tranilast against experimentally induced hepatic encephalopathy. Thioacetamide i... | ['Animals', 'Hepatic Encephalopathy', 'Interleukin-13', 'Interleukin-6', 'Liver', 'Male', 'Nitric Oxide', 'Rats', 'Rats, Sprague-Dawley', 'Thioacetamide', 'ortho-Aminobenzoates'] | 26,164,743 | [['B01.050'], ['C06.552.308.500.356', 'C10.228.140.163.360', 'C18.452.132.360'], ['D12.644.276.374.465.513', 'D12.776.467.374.465.513', 'D23.529.374.465.513'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.465.224'], ['A03.620'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.5... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exploring the protein folding free energy landscape: coupling replica exchange method with P3ME/RESPA algorithm. | A highly parallel replica exchange method (REM) that couples with a newly developed molecular dynamics algorithm particle-particle particle-mesh Ewald (P3ME)/RESPA has been proposed for efficient sampling of protein folding free energy landscape. The algorithm is then applied to two separate protein systems, beta-hairp... | ['Algorithms', 'Computer Simulation', 'Models, Molecular', 'Protein Folding', 'Protein Structure, Secondary', 'Protein Structure, Tertiary', 'Temperature'] | 15,099,840 | [['G17.035', 'L01.224.050'], ['L01.224.160'], ['E05.599.595'], ['G01.154.651', 'G02.111.688'], ['G02.111.570.820.709.600'], ['G02.111.570.820.709.610'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
[Post-traumatic stress disorder following an occupational accident]. | Two cases of occupational accidents and post-traumatic stress disorder (PTSD) of various types are described. These accidents occurred in different occupations and encompass dramatic, life-threatening situations. The cases were compatible with a diagnosis of chronic PTSD. In both cases compensation for occupational inj... | ['Accidental Falls', 'Accidents, Occupational', 'Blast Injuries', 'Denmark', 'Explosions', 'Humans', 'Male', 'Middle Aged', 'Stress Disorders, Post-Traumatic', "Workers' Compensation"] | 10,083,826 | [['N06.850.135.122'], ['N06.850.135.240'], ['C26.120.126'], ['Z01.542.816.124'], ['N06.230.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F03.950.750.500'], ['N03.219.521.346.866', 'N03.219.521.576.300.900']] | ['Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Long non-coding RNA SNHG6 promotes glioma tumorigenesis by sponging miR-101-3p. | INTRODUCTION: Glioma is the most common primary brain tumor. The small nucleolar RNA host gene (SNHG) SNHG6 is a potential oncogene in the development of several types of cancers.METHODS: In this study, we investigated the functional role of long non-coding RNA (lncRNA) SNHG6 in the malignancy of glioma in cell lines a... | ['Animals', 'Apoptosis', 'Carcinogenesis', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Epithelial-Mesenchymal Transition', 'Gene Expression Regulation, Neoplastic', 'Glioma', 'Humans', 'Mice', 'MicroRNAs', 'RNA, Long Noncoding', 'Xenograft Model Antitumor Assays'] | 29,799,357 | [['B01.050'], ['G04.146.954.035'], ['C04.697.098', 'C23.550.727.098'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.356.500'], ['G05.308.370'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['B01.050.150.900.649.31... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An evaluation of direct PCR amplification. | AIM: To generate complete DNA profiles from blood and saliva samples deposited on FTA® and non-FTA® paper substrates following a direct amplification protocol.METHODS: Saliva samples from living donors and blood samples from deceased individuals were deposited on ten different FTA® and non-FTA® substrates. These ten pa... | ['DNA', 'DNA Fingerprinting', 'DNA Primers', 'Gene Amplification', 'Humans', 'Polymerase Chain Reaction', 'Saliva'] | 25,559,837 | [['D13.444.308'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.308.250', 'G05.365.590.310', 'G05.558.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.620.500'], ['A12.200.666']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
The effect of prothrombin fragment 2 on the inhibition of thrombin by antithrombin III. | The effect of prothrombin fragment 2 on the inhibition of thrombin by antithrombin III has been studied. Fragment 2 was found to slow the rate of inhibition of thrombin by antithrombin III about 3-fold. The effect of prothrombin fragment 2 on antithrombin III inhibition was examined by comparing its action in the prese... | ['Animals', 'Antithrombin III', 'Cattle', 'Factor X', 'Kinetics', 'Mathematics', 'Prothrombin', 'Thrombin'] | 447,671 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sinus computerized tomography in primary hypogammaglobulinaemia. | Thirteen patients suffering from primary hypogammaglobulinaemia receiving intravenous immunoglobulin replacement therapy underwent computerized tomography of the paranasal sinuses. The CT scans were evaluated and related to clinical data from the patients, who were selected for study on the basis of having symptoms of ... | ['Adolescent', 'Adult', 'Agammaglobulinemia', 'Aged', 'Chronic Disease', 'Female', 'Humans', 'Immunoglobulins, Intravenous', 'Male', 'Middle Aged', 'Paranasal Sinus Diseases', 'Paranasal Sinuses', 'Retrospective Studies', 'Rhinitis', 'Sinusitis', 'Time Factors', 'Tomography, X-Ray Computed'] | 8,288,967 | [['M01.060.057'], ['M01.060.116'], ['C15.378.147.142', 'C15.604.515.032', 'C20.673.088'], ['M01.060.116.100'], ['C23.550.291.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393.536', 'D12.776.124.486.485.114.632', 'D12.776.124.790.651.114.632', 'D12.776.377.715.548.114.632'], ['M01... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor. | A number of alanine mutations in extracellular loop two (ECL2) of the thyroid-stimulating hormone receptor (TSHR) were found to increase or decrease basal activity when compared with the wild type receptor. K565A was identified as a mutant with decreased basal activity, and strongly impaired hormone induced signaling a... | ['Amino Acid Sequence', 'Amino Acids', 'Animals', 'COS Cells', 'Chlorocebus aethiops', 'Flow Cytometry', 'Humans', 'Models, Biological', 'Models, Molecular', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Mutation', 'Protein Binding', 'Protein Structure, Tertiary', 'Receptors, Thyrotropin'] | 17,079,233 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.125'], ['B01.050'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ovariectomy alters the structural and biomechanical properties of ovine femoro-tibial articular cartilage and increases cartilage iNOS. | OBJECTIVE: To examine the effect of oestrogen depletion produced by surgical ovariectomy on the structural and biomechanical properties of ovine femoro-tibial articular cartilage (AC), and the production of inducible nitric oxide synthase (iNOS) and nitrotyrosine by these tissues.METHODS: Six aged ewes were surgically ... | ['Animals', 'Biomechanical Phenomena', 'Cartilage, Articular', 'Estrogens', 'Female', 'Hindlimb', 'Immunohistochemistry', 'Models, Animal', 'Nitric Oxide', 'Nitric Oxide Synthase Type II', 'Ovariectomy', 'Postmenopause', 'Sheep', 'Tissue Culture Techniques'] | 16,154,775 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['A02.165.407.150', 'A02.835.583.192'], ['D27.505.696.399.472.277'], ['A13.473'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Creating library tutorials for nursing students. | This article describes one librarian's experiences with creating, promoting, and assessing online library tutorials. Tutorials were designed to provide on-demand and accessible library instruction to nursing students at Michigan State University. Topics for tutorials were chosen based on the librarian's liaison experie... | ['Data Collection', 'Humans', 'Internet', 'Library Science', 'Michigan', 'Program Development', 'Students, Nursing', 'Teaching'] | 20,432,135 | [['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['L01.583'], ['Z01.107.567.875.350.500', 'Z01.107.567.875.510.500'], ['N04.452.760'], ['M01.848.769.685'], ['I02.903']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Macro-AST: misleading finding in an adolescent with MCAD-deficiency. | BACKGROUND: MCAD-deficiency is the most common inborn error of fatty acid oxidation now included in many newborn screening programms using MS/MS. During prolonged catabolic episodes, patients may suffer from metabolic decompensation with dysfunction of liver, skeletal- and heart muscle as well as brain. In anabolism, n... | ['Acyl-CoA Dehydrogenase', 'Adolescent', 'Aspartate Aminotransferases', 'Asthma', 'Eosinophilia', 'Female', 'Humans', 'Immunoglobulin E', 'Lipid Metabolism, Inborn Errors', 'Rhinitis, Allergic', 'Rhinitis, Allergic, Perennial'] | 22,935,320 | [['D08.811.682.660.150.100', 'D12.776.331.099'], ['M01.060.057'], ['D08.811.913.477.700.225'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C15.378.553.231'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.776.3... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Diarrhoea in piglets inoculated with rotavirus. | A rotavirus isolated from a field outbreak of diarrhoea in artificially reared piglets was purified, filtered and administered orally to gnotobiotic and conventional piglets. Four successive passages of the virus in gnotobiotic piglets produced severe diarrhoea within 20 to 24 hours of administration. The diarrhoea las... | ['Animal Nutritional Physiological Phenomena', 'Animals', 'Animals, Newborn', 'Diarrhea', 'Germ-Free Life', 'Rotavirus', 'Swine', 'Swine Diseases', 'Virus Diseases'] | 210,755 | [['G07.203.650.161'], ['B01.050'], ['B01.050.050.282'], ['C23.888.821.214'], ['G06.320'], ['B04.820.223.719.790'], ['B01.050.150.900.649.313.500.880'], ['C22.905'], ['C01.925']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Optimal methods of aortoiliac reconstruction. | Alternate methods of aortic reconstruction for aortoiliac occlusive disease were reviewed in one author's (R.C.D.) personal series of 582 patients (1,105 limbs) during the 15 year period from 1963 to 1977. To illustrate certain trends, separate analysis was done for periods 1963 to 1969 (interval I) and 1970 to 1977 (i... | ['Aged', 'Aortic Diseases', 'Arterial Occlusive Diseases', 'Blood Vessel Prosthesis', 'Endarterectomy', 'Female', 'Follow-Up Studies', 'Humans', 'Iliac Artery', 'Male', 'Middle Aged', 'Polyethylene Terephthalates', 'Postoperative Complications', 'Time Factors'] | 152,480 | [['M01.060.116.100'], ['C14.907.109'], ['C14.907.137'], ['E07.695.110'], ['E04.100.814.456'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.114.444'], ['M01.060.116.630'], ['D05.750.728.764', 'D25.720.728.764', 'J01.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Effects of cocaine and reserpine administration on RNA editing of rat 5-HT2C receptor estimated by primer extension combined with denaturing high-performance liquid chromatography. | Serotonin 2C receptor (5-HT(2C)R) transcripts undergo RNA editing, generating pharmacologically different isoforms. To test whether the RNA editing of 5-HT(2C)R is regulated by serotonergic activity, effects of cocaine or reserpine administration in the rat cerebral cortex were examined. Although these drugs have been ... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cerebral Cortex', 'Chromatography, High Pressure Liquid', 'Cocaine', 'Male', 'Molecular Sequence Data', 'Protein Isoforms', 'RNA Editing', 'Rats', 'Rats, Sprague-Dawley', 'Receptor, Serotonin, 5-HT2C', 'Receptors, Serotonin', 'Reserpine'] | 12,439,740 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A08.186.211.200.885.287.500'], ['E05.196.181.400.300'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['L01.453.245.667'], ['D12.776.800'], ['G02.111.760.250... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Childhood obesity as a symptom of genetic syndromes]. | The authors describe on examples from the practice of a genetic clinic seven different genetic syndromes associated with obesity: Laurence-Moon-Biedl, Alstr?m, Weiss, Cohen, Carpenter, Prader-Willi and syndrome of insulin resistance. The autosomal recessive determination of the majority of these syndromes emphasizes th... | ['Abnormalities, Multiple', 'Adolescent', 'Child', 'Child, Preschool', 'Chromosome Aberrations', 'Chromosome Disorders', 'Female', 'Humans', 'Infant', 'Male', 'Obesity'] | 2,752,454 | [['C16.131.077'], ['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.210', 'G05.365.590.175'], ['C16.131.260', 'C16.320.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500']] | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Detection of coagulation factor V in patients with severe hepatitis and its clinical significance]. | BACKGROUND: To investigate the prognostic significance and role of coagulation factor V (CFV) levels in clinical diagnostic criteria for severe hepatitis.METHODS: The CFV level and prothrombin activity (PTA) were tested by turbidimetry for 129 times in 58 patients with severe hepatitis. Comparative studies and clinical... | ['Adult', 'Aged', 'Diagnostic Techniques and Procedures', 'Factor V', 'Female', 'Hepatitis', 'Humans', 'Male', 'Middle Aged', 'Nephelometry and Turbidimetry', 'Prognosis', 'Prothrombin', 'Young Adult'] | 15,340,576 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370'], ['D12.776.124.125.300', 'D12.776.811.272', 'D23.119.300'], ['C06.552.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.196.712.650'], ['E01.789'], ['D08.622.709', 'D12.776.124.125.800', 'D12.776.811.243.709', 'D23.119.945'], ['M01.060.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials. | BACKGROUND: A one-dose-fits-all approach to use of aspirin has yielded only modest benefits in long-term prevention of cardiovascular events, possibly due to underdosing in patients of large body size and excess dosing in patients of small body size, which might also affect other outcomes.METHODS: Using individual pati... | ['Age Factors', 'Aged', 'Aspirin', 'Body Height', 'Body Weight', 'Cardiovascular Diseases', 'Colorectal Neoplasms', 'Death, Sudden', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Platelet Aggregation Inhibitors', 'Proportional Hazards Models', 'Randomized Controlled Trials as Topic', 'Risk Factors', 'Sex Factor... | 30,017,552 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D02.455.426.559.389.657.410.595.176'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120']... | ['Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and beta-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain. | The up-regulation of the angiogenic vascular endothelial growth factor (VEGF) in brains of Alzheimer patients in close relationship to beta-amyloid (Abeta) plaques, suggests a link of VEGF action and processing of the amyloid precursor protein (APP). To reveal whether VEGF may affect APP processing, brain slices derive... | ['Alzheimer Disease', 'Amyloid Precursor Protein Secretases', 'Amyloid beta-Peptides', 'Amyloid beta-Protein Precursor', 'Animals', 'Biological Assay', 'Brain', 'Down-Regulation', 'Female', 'Humans', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Neurons', 'Organ Culture Techniques', 'Peptide Fragments', 'P... | 19,589,380 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D08.811.277.656.300.032'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['D12.776.049.407.249', 'D12.776.543.039', 'D12.776.645.468.500', 'D12.776.811.050'], ['B01.050'], ['E05.091'], ['A08.186.211'], ['G02.111.240', 'G05.308.200', ... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of different ð-bridge configuration on bi-anchored triphenylamine and phenyl modified triphenylamine based dyes for dye sensitized solar cell (DSSC) application: A theoretical approach. | Twenty eight bi-anchored triphenylamine (TH-1 to TH-14) and phenyl modified triphenylamine (PH-TH-1 to PH-TH-14) based metal free organic dyes are designed for DSSC application. The electronic effect of different ð-bridge configurations in donor-ð-bridge-acceptor (D-ð-A)2 structure was theoretically simulated and verif... | ['Algorithms', 'Amines', 'Coloring Agents', 'Electric Power Supplies', 'Models, Molecular', 'Models, Theoretical', 'Molecular Conformation', 'Molecular Structure', 'Spectrum Analysis', 'Thiophenes'] | 29,272,760 | [['G17.035', 'L01.224.050'], ['D02.092'], ['D27.720.233'], ['E07.305.124'], ['E05.599.595'], ['E05.599'], ['G02.111.570.820'], ['G02.111.570', 'G02.466'], ['E05.196.867'], ['D02.886.778', 'D03.383.903']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Phase 2 study of sunitinib in patients with metastatic mucosal or acral melanoma. | BACKGROUND: Patients with mucosal and acral melanomas have limited treatment options and a poor prognosis. Mutations of the KIT oncogene in these melanoma subtypes provide a potential therapeutic target.METHODS: A multicenter phase 2 trial of sunitinib was conducted in patients with unresectable stage III or IV melanom... | ['Antineoplastic Agents', 'Female', 'Humans', 'Indoles', 'Male', 'Melanoma', 'Mucous Membrane', 'Mutation', 'Proto-Oncogene Proteins c-kit', 'Pyrroles', 'Skin Neoplasms', 'Sunitinib'] | 26,264,378 | [['D27.505.954.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['A10.615.550'], ['G05.365.590'], ['D08.811.913.696.620.682.725.400.050', 'D12.776.543.750.630.124', 'D12.776.543.750.705.852.150.100', 'D12.776.543.750.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Detection of deletions in de novo "balanced" chromosome rearrangements: further evidence for their role in phenotypic abnormalities. | PURPOSE: The purpose of this study was to test the hypothesis that deletions of varying sizes in de novo apparently balanced chromosome rearrangements are a significant cause of phenotypic abnormalities.METHODS: A total of fifteen patients, with seemingly balanced de novo rearrangements by routine cytogenetic analysis ... | ['Chromosome Banding', 'Chromosomes, Artificial, Bacterial', 'Chromosomes, Human, X', 'Cytogenetic Analysis', 'Female', 'Gene Deletion', 'Gene Rearrangement', 'Human Genome Project', 'Humans', 'In Situ Hybridization, Fluorescence', 'Male', 'Phenotype', 'Spectrophotometry, Ultraviolet'] | 15,017,330 | [['E01.370.225.500.385.130', 'E01.370.225.500.620.670.130', 'E01.370.225.750.600.670.130', 'E05.200.500.385.130', 'E05.200.500.620.670.130', 'E05.200.750.600.670.130', 'E05.242.385.130', 'E05.393.285.130'], ['A11.284.187.178.170', 'A11.284.187.190.170', 'A20.812.170', 'G05.360.162.178.170', 'G05.360.162.190.170', 'G05.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Ideal or actual body weight to calculate CD34+ cell doses for allogeneic hematopoietic stem cell transplantation? | The number of CD34+ cells infused influences hematologic recovery after transplantation. Limited data suggest that cell dose should be based on ideal (IBW) rather than actual (ABW) body weight for autotransplantation, but none in allografts. We compared the correlation between recovery to 0.5 x 10(9)/l neutrophils and ... | ['Acute Disease', 'Adult', 'Antigens, CD34', 'Body Weight', 'Chronic Disease', 'Female', 'Hematopoietic Stem Cell Transplantation', 'Hematopoietic Stem Cells', 'Humans', 'Leukemia', 'Lymphoma', 'Male', 'Middle Aged', 'Neutrophils', 'Retrospective Studies', 'Transplantation, Homologous'] | 14,647,242 | [['C23.550.291.125'], ['M01.060.116'], ['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C23.550.291.500'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['A11.148.378', 'A11.872.378', 'A15.378... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Granuloma faciale. | The development of our present knowledge of granuloma faciale is summarized, and the clinical picture, absence of systemic illness, and distinct histopathologic features are briefly described. The differential diagnoses are noted, and the fact that the histopathologic features can almost always readily confirm the diag... | ['Aged', 'Diagnosis, Differential', 'Facial Dermatoses', 'Female', 'Granuloma', 'Humans', 'Skin', 'Triamcinolone'] | 884,962 | [['M01.060.116.100'], ['E01.171'], ['C17.800.271'], ['C15.604.515.292', 'C23.550.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A17.815'], ['D04.210.500.745.432.915', 'D04.210.500.908.891']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Concentrative nucleoside transporter (rCNT1) is targeted to the apical membrane through the hepatic transcytotic pathway. | The Na+-dependent nucleoside transporter CNT1 has been identified in a caveolin-enriched plasma membrane fraction (CEF), in transcytotic endosomes, and in canalicular membranes isolated from quiescent rat liver in which the transporter appears to be biologically active. CNT1 was also detected, albeit in small amounts, ... | ['Animals', 'Biological Transport, Active', 'Blotting, Western', 'Caveolae', 'Cell Membrane', 'Endosomes', 'Fluorescent Antibody Technique', 'Hepatocytes', 'Immunohistochemistry', 'Membrane Transport Proteins', 'Microscopy, Electron', 'Plasmids', 'Protein Isoforms', 'Purine Nucleosides', 'Rats', 'Recombinant Proteins'] | 12,441,131 | [['B01.050'], ['G03.143.310'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.284.149.165.175.160', 'A11.284.149.165.570.160', 'A11.284.430.214.190.875.190.880.180.160'], ['A11.284.149'], ['A11.284.430.214.190.875.190.880.337'], ['E01.370.225.500.607.512.240',... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Anti-obesity and anti-diabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance. | OBJECTIVE: Obesity in rodents and humans is mostly associated with elevated plasma leptin concentrations, suggesting a new pathological concept of 'leptin resistance'. We have demonstrated that brain-derived neurotrophic factor (BDNF) can improve obesity and diabetes of C57BL/KsJ db/db (db/db) mice. In this study, we i... | ['Animals', 'Blood Glucose', 'Brain-Derived Neurotrophic Factor', 'Diabetes Mellitus', 'Drug Evaluation, Preclinical', 'Drug Resistance', 'Eating', 'Glucose Tolerance Test', 'Insulin', 'Leptin', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Obesity'] | 12,704,399 | [['B01.050'], ['D09.947.875.359.448.500'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['C18.452.394.750', 'C19.246'], ['E05.290.750', 'E05.337.550'], ['G07.690.773.984'], ['G07.203.650.283', 'G10.261.330'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.35... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Optimization of cardiac resynchronization therapy by continuous hemodynamic monitoring:. | We report the case of a 55-year-old male patient with severe congestive heart failure in whom both a hemodynamic monitor and a biventricular pacemaker were implanted. The potential usefulness of the monitor to optimize AV delay and heart rate was prospectively evaluated. The AV delay associated with the lowest filling ... | ['Blood Pressure Determination', 'Cardiac Pacing, Artificial', 'Electrocardiography', 'Heart Failure', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Quality Control', 'Therapy, Computer-Assisted', 'Treatment Outcome'] | 15,028,081 | [['E01.370.370.140', 'E01.370.600.100'], ['E02.331.200'], ['E01.370.370.380.240', 'E01.370.405.240'], ['C14.280.434'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['J01.897.608'], ['E02.950', 'L01.313.500.750.100.710'], ['E01.789.800', 'N04.761.559.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). | Streptomyces coelicolor is a representative of the group of soil-dwelling, filamentous bacteria responsible for producing most natural antibiotics used in human and veterinary medicine. Here we report the 8,667,507 base pair linear chromosome of this organism, containing the largest number of genes so far discovered in... | ['Bacterial Proteins', 'Chromosomes, Bacterial', 'Corynebacterium diphtheriae', 'Genes, Bacterial', 'Genes, Duplicate', 'Genome, Bacterial', 'Genomics', 'Molecular Sequence Data', 'Multigene Family', 'Mycobacterium tuberculosis', 'Protein Isoforms', 'Streptomyces', 'Synteny'] | 12,000,953 | [['D12.776.097'], ['A11.284.187.190', 'A20.812', 'G05.360.162.190'], ['B03.510.024.250.150', 'B03.510.460.400.400.200.150'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.360.340.024.340.250'], ['G05.360.340.358.207'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['L01.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Emotional distress in doctors: sources, effects and help sought. | All doctors in a London Teaching Hospital were sent a self-administered, anonymous questionnaire, to study past episodes of emotional distress. We inquired about frequency of past and current emotional distress, sources of distress, effects on work and home life, type of help sought and perceived outcome of that help. ... | ['Adult', 'Age Factors', 'Alcohol Drinking', 'Emotions', 'Humans', 'London', 'Medical Staff, Hospital', 'Mental Health', 'Middle Aged', 'Occupational Diseases', 'Patient Acceptance of Health Care', 'Prevalence', 'Risk Factors', 'Stress, Psychological', 'Workload'] | 1,433,036 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.145.317.269'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.433.553', 'Z01.542.363.300.553'], ['M01.526.485.630.490', 'M01.526.485.740.422', 'N02.360.630.490', 'N02.360.740.422'], ['F02.418', 'N01.400.500'], ['M01.060.116.630'], ['C2... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
C/EBPâ is involved in the amplification of early granulocyte precursors during candidemia-induced "emergency" granulopoiesis. | Granulopoiesis is tightly regulated to meet host demands during both "steady-state" and "emergency" situations, such as infections. The transcription factor CCAAT/enhancer binding protein â (C/EBPâ) plays critical roles in emergency granulopoiesis, but the precise developmental stages in which C/EBPâ is required are un... | ['Animals', 'CCAAT-Enhancer-Binding Protein-beta', 'Candidemia', 'Flow Cytometry', 'Gene Amplification', 'Granulocytes', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Myeloid Progenitor Cells', 'Time Factors'] | 23,024,276 | [['B01.050'], ['D12.776.260.108.124.750', 'D12.776.660.167.750', 'D12.776.930.127.124.750'], ['C01.150.703.160.175.500', 'C01.150.703.492.500.500', 'C01.757.360.150', 'C23.550.470.790.500.360.150'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tuning the bioactivity of bone morphogenetic protein-2 with surface immobilization strategies. | Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinical application is restricted due to the undesirable bioactivity and relevant complications in vivo. Immobilization of recombinant BMP-2 (rhBMP-2) is an efficient strategy to mimic natural microenvironme... | ['Animals', 'Biocompatible Materials', 'Bone Morphogenetic Protein 2', 'Cell Adhesion', 'Cell Differentiation', 'Cell Line', 'Drug Liberation', 'Gold', 'Heparin', 'Immobilized Proteins', 'Male', 'Mice, Inbred C57BL', 'Osteogenesis', 'Polylactic Acid-Polyglycolic Acid Copolymer', 'Recombinant Proteins', 'Surface Propert... | 30,218,780 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D12.644.276.954.200.200', 'D12.776.467.942.200.200', 'D23.529.942.200.200'], ['G04.022'], ['G04.152'], ['A11.251.210'], ['G02.211', 'G03.787.321', 'G07.690.725.321'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['D09.698.373.400'], ['D12.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Lithium carbonate and granulocyte production: dose optimization. | To determine the optimal dose of lithium for inducing granulocytosis, the authors administered lithium carbonate to normal volunteers at five dose levels. The authors performed assessments of circulating and marginated blood pools of granulocytes and of marrow reserve granulocytes to confirm that the early granulocytos... | ['Adult', 'Bleeding Time', 'Blood Platelets', 'Dose-Response Relationship, Drug', 'Epinephrine', 'Granulocytes', 'Humans', 'Hydrocortisone', 'Leukocyte Count', 'Leukocytosis', 'Lithium', 'Lithium Carbonate', 'Time Factors'] | 6,796,251 | [['M01.060.116'], ['E01.370.225.625.625.100', 'E05.200.625.625.100', 'G09.188.087'], ['A11.118.188', 'A15.145.229.188'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['A11.118.637.415', 'A11.148.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Salivary habituation to food stimuli in successful weight loss maintainers, obese and normal-weight adults. | OBJECTIVE: Research shows that slower habituation of salivary responses to food stimuli is related to greater energy intake and that obese (Ob) individuals habituate slower than those of normal weight (NW). No study has examined habituation rates in weight loss maintainers (WLMs) who have reduced from obese to normal w... | ['Adult', 'Aged', 'Body Weight', 'Feeding Behavior', 'Female', 'Food', 'Habituation, Psychophysiologic', 'Humans', 'Male', 'Middle Aged', 'Obesity', 'Salivation', 'Satiation', 'Weight Loss'] | 20,010,900 | [['M01.060.116'], ['M01.060.116.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['G07.203.300', 'J02.500'], ['F02.463.425.393', 'F02.830.422', 'G11.561.312'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Metoclopramide given pre-operatively empties the stomach. | Sixty adult patients admitted for emergency major orthopedic surgery were studied according to a double-blind, randomized design in order to evaluate if a single dose of 20 mg metoclopramide given intravenously at least 90 min before premedication could evacuate the stomach before anesthesia. Three patients were exclud... | ['Adult', 'Aged', 'Double-Blind Method', 'Drug Evaluation', 'Female', 'Gastric Emptying', 'Humans', 'Male', 'Metoclopramide', 'Middle Aged', 'Pneumonia, Aspiration', 'Preanesthetic Medication', 'Radiography', 'Random Allocation', 'Stomach'] | 3,993,321 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E05.290.625', 'E05.337.425'], ['G10.261.360.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.065.277.573', 'D02.241.223.100.050.500.647', 'D02.241.223.100.100.510', 'D02.241.223.10... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Rubrimonas shengliensis sp. nov. and Polymorphum gilvum gen. nov., sp. nov., novel members of Alphaproteobacteria from crude oil contaminated saline soil. | Four bacterial strains were isolated from a crude oil contaminated saline soil in Shengli Oilfield, China. Strains SL014B-28A2(T) and SL014B-80A1 were most closely related to Rubrimonas cliftonensis OCh 317(T), while strains SL003B-26A1(T) and SL003B-26A2 were most closely related to but readily different from the spec... | ['Base Composition', 'China', 'DNA, Bacterial', 'Fatty Acids', 'Genes, Bacterial', 'Genes, rRNA', 'Lipids', 'Molecular Sequence Data', 'Phylogeny', 'RNA, Ribosomal, 16S', 'Rhodobacteraceae', 'Soil Microbiology', 'Ubiquinone'] | 21,600,718 | [['G02.111.080'], ['Z01.252.474.164'], ['D13.444.308.212'], ['D10.251'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.360.340.024.340.645.750'], ['D10'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.686.670'], ['B03.660.050.750'], ['H01.15... | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Analysis of biologically active compounds in water by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry. | A new method based on ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight mass spectrometry ((Q-ToF)-MS) was developed for the analysis of 32 biologically active compounds including anti-inflammatories, analgesics, lipid regulators, psychiatric drugs, anti-ulcer agents, antibiotics, beta-blockers a... | ['Chromatography, High Pressure Liquid', 'Indicators and Reagents', 'Mass Spectrometry', 'Pharmaceutical Preparations', 'Phytoestrogens', 'Reproducibility of Results', 'Sewage', 'Water', 'Water Pollutants, Chemical'] | 18,050,241 | [['E05.196.181.400.300'], ['D27.720.470.410'], ['E05.196.566'], ['D26'], ['D27.505.696.399.472.277.540.500'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['D20.944.932.500'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925'], ['D27.888.284.903.655']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
NK1.1+ CD4+ CD8- thymocytes with specific lymphokine secretion. | CD4+8- or CD4-8+ thymocytes have been regarded as direct progenitors of peripheral T cells. However, recently, we have found a novel NK1.1+ subpopulation with skewed T cell antigen receptor (TcR) V beta family among heat-stable antigen negative (HSA-) CD4+8- thymocytes. In the present study, we show that these NK1.1+ C... | ['Animals', 'Antigens', 'Antigens, Ly', 'Antigens, Surface', 'CD3 Complex', 'CD4 Antigens', 'CD8 Antigens', 'Interferon-gamma', 'Interleukin-2', 'Interleukin-4', 'Lectins, C-Type', 'Lymphokines', 'Mice', 'NK Cell Lectin-Like Receptor Subfamily B', 'Proteins', 'T-Lymphocytes'] | 8,419,184 | [['B01.050'], ['D23.050'], ['D23.050.301.264.920', 'D23.101.100.920'], ['D23.050.301'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['D12.776.543.750.705.852.420.810.500', 'D12.776.543.750.830.700.025', 'D23.050.301.264.894.100', 'D23.101.100.894.100'], ['D23.050.301.264.894.108', 'D23.101.100.894.108'], ['D12.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stepping stones in the electron transport from cells to electrodes in Geobacter sulfurreducens biofilms. | Geobacter sulfurreducens bacteria grow on biofilms and have the particular ability of using polarized electrodes as the final electron acceptor of their respiratory chain. In these biofilms, electrons are transported through distances of more than 50 ìm before reaching the electrode. The way in which electrons are tran... | ['Biofilms', 'Cytochromes', 'Electrodes', 'Electron Transport', 'Fimbriae, Bacterial', 'Geobacter'] | 23,698,325 | [['A20.593', 'G06.120'], ['D08.244', 'D12.776.422.220'], ['E07.305.250'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['A11.284.180.285', 'A20.843'], ['B03.440.425.410.430', 'B03.660.125.305']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Satellite cells in the normal human adrenal gland and in pheochromocytomas. An immunohistochemical study. | In light of the recent finding of the S-100 antigen in satellite cells of the rat adrenal medulla, we looked for S-100-labelled cells in both the normal human adrenal medulla and in pheochromocytomas. Immunostaining enabled us to detect S-100-labelled satellite cells by both light and electron microscopy in a significa... | ['Adrenal Gland Neoplasms', 'Adrenal Medulla', 'Histocytochemistry', 'Humans', 'Immunologic Techniques', 'Pheochromocytoma', 'S100 Proteins'] | 2,862,732 | [['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['A06.300.071.265'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478'], ['C04.557.465.625.650.700.725', 'C04.5... | ['Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Resonance Raman studies of acetylheme-reconstituted myoglobins. Characterization of 2- versus 4-substituent/protein interactions. | Resonance Raman (RR) spectra are reported for the deoxy, oxy, and metcyano species of sperm whale myoglobin (Mb) reconstituted with deuteroheme, 2-acetyldeuteroheme, 4-acetyldeuteroheme, and 2,4-diacetyldeuteroheme. The functional inequivalence of the 2- and 4-positions of the heme moiety is manifested in the vibration... | ['Deuterium', 'Heme', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Myoglobin', 'Spectrum Analysis, Raman', 'Structure-Activity Relationship'] | 3,442,657 | [['D01.268.406.500', 'D01.362.340.500', 'D01.496.289'], ['D03.383.129.578.840.500.640.587', 'D03.633.400.909.500.640.587', 'D04.345.783.500.640.587', 'D23.767.727.640.587'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['D12.776.210.500.588', 'D12.776.422.316.940'], ['E05.196.822.860', 'E05.196.867.890'], ['G02... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of a novel p53 mutation in JCV-induced mouse medulloblastoma. | Medulloblastoma, a malignant invasive tumor of the cerebellum, is one of the most common neoplasms of the nervous system in children. Utilization of the human neurotropic virus JC virus (JCV) early gene T-antigen allowed the development of a transgenic animal that models human medulloblastoma. Here we describe the char... | ['Animals', 'Antigens, Polyomavirus Transforming', 'Cerebellar Neoplasms', 'Cerebellum', 'Humans', 'JC Virus', 'Medulloblastoma', 'Mice', 'Mice, Nude', 'Mice, Transgenic', 'Mutation', 'Tumor Cells, Cultured', 'Tumor Suppressor Protein p53'] | 10,936,089 | [['B01.050'], ['D12.776.624.664.520.090', 'D12.776.964.700.090', 'D23.050.285.062.090', 'D23.050.327.062.090'], ['C04.588.614.250.195.411.211', 'C10.228.140.211.500.200', 'C10.228.140.252.200', 'C10.551.240.250.400.300'], ['A08.186.211.132.810.428.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B04.280.210.70... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structures and antioxidant and intestinal disaccharidase inhibitory activities of A-type proanthocyanidins from peanut skin. | Nine compounds including a new A-type proanthocyanidin trimer, epicatechin-(2â?O?7,4â?8)-[catechin-(6?4â)]-epicatechin (8), and a known trimer, epicatechin-(4â?8)-epicatechin-(2â?O?7,4â?8)-catechin (9), being reported for peanut skin for the first time, were isolated and purified. Their structures were determined by sp... | ['Antioxidants', 'Arachis', 'Enzyme Inhibitors', 'Glycoside Hydrolase Inhibitors', 'Humans', 'Intestines', 'Kinetics', 'Molecular Structure', 'Plant Extracts', 'Proanthocyanidins', 'Seeds', 'Sucrase', 'alpha-Glucosidases'] | 23,971,511 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['B01.650.940.800.575.912.250.401.077'], ['D27.505.519.389'], ['D27.505.519.389.320', 'D27.505.696.422.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124'], ['G01.374.661', 'G02.111.490'], ['G02.111.570', 'G02.466'], ['D20.215.784.500', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Changes in thromboelastogram in women on hormonal contraception]. | The authors have analysed changes in the thromboelastogram in 411 women on oral contraceptives and in 31 women on no hormonal contraception. Comparing the results they found no statistically significant differences because the control group was too small. In the group of women on hormonal contraception, statistically s... | ['Adult', 'Blood Coagulation Disorders', 'Contraceptives, Oral', 'Female', 'Humans', 'Thrombelastography', 'Thromboembolism', 'Time Factors'] | 1,027,924 | [['M01.060.116'], ['C15.378.100'], ['D27.505.696.875.360.276.210', 'D27.505.954.705.360.276.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.625.115.830', 'E05.200.625.115.830'], ['C14.907.355.590'], ['G01.910.857']] | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effect of protest zeros on estimates of willingness to pay in healthcare contingent valuation analysis. | 'Protest zeros' occur when respondents reject some aspect of the contingent valuation (CV) market scenario by reporting a zero value even though they place a positive value on the amenity being valued. This is inevitable even in the best-designed CV study, and, when excluded on an ad hoc basis, may cause a selection bi... | ['Adult', 'Antimalarials', 'Cameroon', 'Cost-Benefit Analysis', 'Female', 'Game Theory', 'Health Expenditures', 'Humans', 'Insect Control', 'Interviews as Topic', 'Malaria', 'Male', 'Middle Aged', 'Models, Econometric', 'Young Adult'] | 20,578,778 | [['M01.060.116'], ['D27.505.954.122.250.100.085'], ['Z01.058.290.100.110'], ['N03.219.151.125'], ['G17.388'], ['N03.219.151.450', 'N05.300.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.780.200.650.425'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['C01.610.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1. | The triple-helical cyanogen-bromide-derived fragment CB3[IV] of collagen IV, located 100 nm from the N-terminus of the molecule, contains the binding sites for the integrins alpha 1 beta 1 and alpha 2 beta 1. To investigate the interaction of these integrins and collagen IV, we performed solid-phase and inhibition assa... | ['Amino Acid Sequence', 'Binding Sites', 'Collagen', 'Humans', 'Integrins', 'Molecular Sequence Data', 'Protein Structure, Secondary'] | 8,344,274 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['D05.750.078.280', 'D12.776.860.300.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543.750.705.408'], ['L01.453.245.667'], ['G02.111.570.820.709.600']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Optogenetic characterization methods overcome key challenges in synthetic and systems biology. | Systems biologists aim to understand how organism-level processes, such as differentiation and multicellular development, are encoded in DNA. Conversely, synthetic biologists aim to program systems-level biological processes, such as engineered tissue growth, by writing artificial DNA sequences. To achieve their goals,... | ['Algorithms', 'Animals', 'Cell Line', 'DNA', 'Electricity', 'Electrons', 'Extracellular Signal-Regulated MAP Kinases', 'Gene Expression Regulation', 'Light', 'Optogenetics', 'Signal Transduction', 'Synthetic Biology', 'Systems Biology', 'ras Proteins'] | 24,937,068 | [['G17.035', 'L01.224.050'], ['B01.050'], ['A11.251.210'], ['D13.444.308'], ['G01.358.500.249'], ['G01.249.335', 'G01.358.500.750'], ['D08.811.913.696.620.682.700.567.249', 'D12.644.360.450.169', 'D12.776.476.450.169'], ['G05.308'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.393... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Higher temperatures increase developmental rate & reduce body size at hatching in the small-eyed skate Raja microocellata: implications for exploitation of an elasmobranch in warming seas. | Effects of temperature on development of Raja microocellata was tested by maintaining embryos in controlled conditions representative of those predicted under current climate scenarios. There was a positive relationship between size of neonates & developmental rate: temperatures 14.5-16.5°C produced skates 3.5-7%, resp... | ['Adaptation, Biological', 'Analysis of Variance', 'Animals', 'Body Size', 'Female', 'Hot Temperature', 'Male', 'Oceans and Seas', 'Seawater', 'Skates, Fish'] | 31,049,955 | [['G16.012'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['G... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Carotid sinus hypersensitivity: a cause of syncope in patients with tumors of the head and neck. | Carotid sinus hypersensitivity secondary to the presence of an underlying head and neck cancer has only recently been discussed in the literature. We present seven cases of carotid sinus hypersensitivity, each with paroxysmal bradycardia and hypotension associated both with and without palpation of the carotid bifucati... | ['Aged', 'Bradycardia', 'Carotid Artery Diseases', 'Carotid Sinus', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Hypotension', 'Male', 'Middle Aged', 'Syncope'] | 6,621,227 | [['M01.060.116.100'], ['C14.280.067.319', 'C23.550.073.300'], ['C10.228.140.300.200', 'C14.907.253.123'], ['A07.015.114.186.456'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.514'], ['M01.060.116.630'], ['C10.597.606.358.800.600', 'C23.888.592.604.359.800.600']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Periungual capillaroscopy patterns in normal children]. | In children as well as in adults, capillaroscopy is an unsophisticated and non invasive technique which allows to investigate vascular acrosyndromes and systemic diseases. We have studied nailfold capillaroscopy patterns in 80 children without over vascular or systemic disease: pericapillary halos and haemorrhages incr... | ['Adolescent', 'Adult', 'Capillaries', 'Child', 'Child, Preschool', 'Dermatomyositis', 'Fingers', 'Humans', 'Infant', 'Infant, Newborn', 'Lupus Erythematosus, Systemic', 'Nails', 'Radiography', 'Reference Values', 'Scleroderma, Systemic', 'Time Factors'] | 1,610,272 | [['M01.060.057'], ['M01.060.116'], ['A07.015.461.165'], ['M01.060.406'], ['M01.060.406.448'], ['C05.651.594.819.500', 'C10.668.491.562.575.500', 'C17.300.250', 'C17.800.185'], ['A01.378.800.667.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C17.300.480', 'C20.111.590'], ... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Protein quality and quantity influence free amino acid levels in the brain and serum of rats during lactation. | Diets containing 11 or 21% protein supplied by wheat, wheat + lysine + threonine or casein + methionine were fed to pregnant rats from conception until d 4 or 8 of lactation. Dams then were decapitated, serum was collected and brains and left inguinal-abdominal mammary glands were quickly excised and weighed. Serum and... | ['Amino Acids', 'Animals', 'Birth Weight', 'Body Weight', 'Brain', 'Caseins', 'Dietary Proteins', 'Eating', 'Female', 'Lactation', 'Litter Size', 'Lysine', 'Mammary Glands, Animal', 'Methionine', 'Organ Size', 'Pregnancy', 'Rats', 'Threonine', 'Triticum'] | 1,907,314 | [['D12.125'], ['B01.050'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['A08.186.211'], ['D12.776.256.159.750.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effect of Clopidogrel and Aspirin vs Aspirin Alone on Migraine Headaches After Transcatheter Atrial Septal Defect Closure: The CANOA Randomized Clinical Trial. | IMPORTANCE: The occurrence of new-onset migraine attacks is a complication of transcatheter atrial septal defect (ASD) closure. It has been suggested that clopidogrel may reduce migraine attacks after ASD closure.OBJECTIVE: To assess the efficacy of clopidogrel, used in addition to taking aspirin, for the prevention of... | ['Aspirin', 'Cardiac Catheterization', 'Cardiac Surgical Procedures', 'Clopidogrel', 'Double-Blind Method', 'Drug Therapy, Combination', 'Female', 'Headache Disorders, Secondary', 'Heart Septal Defects, Atrial', 'Humans', 'Male', 'Middle Aged', 'Migraine Disorders', 'Platelet Aggregation Inhibitors', 'Regression Analys... | 26,551,304 | [['D02.455.426.559.389.657.410.595.176'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E04.100.376', 'E04.928.220'], ['D02.886.778.823.500.500', 'D03.383.725.849.500.500', 'D03.383.903.830.500.500', 'D03.633.100.928.500.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.30... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Reproducibility of the ventricular synchronization parameters assessed by multiharmonic phase analysis of radionuclide angiography in the normal heart. | Radionuclide angiography (RNA) permits analysis of contractility and conduction abnormalities. We determined the parameters of normal ventricular synchronization, assessed the reproducibility of the technique, and compared first harmonic (1H) and third harmonic (3H) analysis. Forty-four normal subjects (28 men and 16 w... | ['Female', 'Fourier Analysis', 'Heart Ventricles', 'Humans', 'Linear Models', 'Male', 'Middle Aged', 'Radionuclide Angiography', 'Reference Values', 'Reproducibility of Results', 'Ventricular Function'] | 12,123,310 | [['E05.377', 'G17.226', 'L01.224.800.625'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['M01.060.116.630'], ['E01.370.350.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Named Groups [M]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Fibroblast growth factor 2 can replace ectodermal signaling for feather development. | The initiation and morphogenesis of cutaneous appendages depend on a series of reciprocal signaling events between the epithelium and mesenchyme of the embryonic skin. In the development of feather germs, early dermal signals induce the formation of epidermal placodes that in turn signal the mesoderm to form dermal con... | ['Animals', 'Chick Embryo', 'Ectoderm', 'Feathers', 'Fibroblast Growth Factor 2', 'Gene Expression Regulation, Developmental', 'In Situ Hybridization', 'Receptor Protein-Tyrosine Kinases', 'Receptor, Fibroblast Growth Factor, Type 1', 'Receptors, Fibroblast Growth Factor', 'Signal Transduction', 'Skin', 'Skin Abnormali... | 8,816,784 | [['B01.050'], ['A13.350.150', 'A16.331.200'], ['A16.504.273'], ['A13.370'], ['D12.644.276.624.120', 'D12.776.467.624.120', 'D23.529.624.120'], ['G05.308.310'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['D08.811.913.696.620.6... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[An unfolding model for confusion matrices]. | An unfolding model is proposed for analyzing the confusion matrices obtained from stimulus identification experiments. In the model, row and column stimuli in the matrices are represented as two sets of points in a multidimensional space, and confusion probabilities are expressed as a function of the distances between ... | ['Choice Behavior', 'Confusion', 'Humans', 'Models, Psychological', 'Psychiatric Status Rating Scales'] | 7,666,611 | [['F02.463.785.373.346'], ['C10.597.606.337', 'C23.888.592.604.339', 'F01.700.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.695'], ['F04.711.513.653']] | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rescue of biosynthesis of nicotinamide adenine dinucleotide protects the heart in cardiomyopathy caused by lamin A/C gene mutation. | Cardiomyopathy caused by lamin A/C gene (LMNA) mutations (hereafter referred as LMNA cardiomyopathy) is an anatomic and pathologic condition associated with muscle and electrical dysfunction of the heart, often leading to heart failure-related disability. There is currently no specific therapy available for patients th... | ['Animals', 'Cardiomyopathies', 'Disease Models, Animal', 'Heart', 'Heart Failure', 'Heart Ventricles', 'Humans', 'Lamin Type A', 'Mice', 'Mutation', 'NAD', 'Niacinamide', 'Poly (ADP-Ribose) Polymerase-1', 'Poly ADP Ribosylation', 'Ventricular Dysfunction, Left'] | 30,053,027 | [['B01.050'], ['C14.280.238'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A07.541'], ['C14.280.434'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.660.650.875.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['G05.365.590'], ['D03.633.100.759.646.138.694', 'D08.211.589', 'D13.695... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The evaluation of the temporal lobe size by magnetic resonance in Alzheimer's disease]. | The estimation of the size of the structures of the temporal lobe using magnetic resonance (MR) can be of assistance when diagnosing early degenerative dementia. We have carried out a survey on 17 patients with Alzheimer type dementia (ATD). They were classified in clinical stages according to the Reisberg global deter... | ['Aged', 'Alzheimer Disease', 'Diagnosis, Computer-Assisted', 'Functional Laterality', 'Hippocampus', 'Humans', 'Magnetic Resonance Imaging', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Severity of Illness Index', 'Temporal Lobe'] | 8,548,645 | [['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['E01.158', 'L01.313.500.750.100.158'], ['F02.830.297.425', 'G11.561.225.425'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Using transposons for genetic mosaic analysis of plant development. | Genetic mosaics, or chimeras, are individual organisms composed of cells or tissues of two or more distinct genotypes. They are experimentally useful for addressing several key biological questions. These include fate mapping through analysis of marked clonal lineages, analyzing cell or tissue interactions such as the ... | ['Alleles', 'Chimera', 'Chromosome Breakage', 'DNA Transposable Elements', 'Gene Silencing', 'Genetic Engineering', 'Mutation', 'Transposases', 'Zea mays'] | 23,918,419 | [['G05.360.340.024.340.030'], ['B05.200'], ['C23.550.210.170', 'G05.200.210.170', 'G05.365.590.175.175'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['G05.308.203.374'], ['E05.393.420'], ['G05.365.590'], ['D08.811.739.500.667', 'D08.811.913.696.445.825'], [... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence of high-risk sexual behaviour in Jamaican adults and its relationship to sociodemographic and religious factors: findings from the Jamaica Health and Lifestyle Survey 2007-2008. | OBJECTIVE: To estimate the prevalence of high-risk sexual behaviours among Jamaican adults and evaluate associations with sociodemographic and religious factors.METHODS: We performed a cross-sectional study, using a nationally representative sample of Jamaicans, 15-74 years old. Participants completed an interviewer-ad... | ['Acquired Immunodeficiency Syndrome', 'Adolescent', 'Adult', 'Aged', 'Cross-Sectional Studies', 'Female', 'HIV Infections', 'Health Surveys', 'Humans', 'Jamaica', 'Male', 'Marital Status', 'Middle Aged', 'Odds Ratio', 'Religion and Medicine', 'Sex Factors', 'Sexually Transmitted Diseases', 'Socioeconomic Factors', 'Su... | 24,020,227 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C01.221.250.875'... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Use of isozyme patterns in the identification of Biomphalaria tenagophila (D'Orbigny, 1835) and B. occidentalis (Paraense, 1981) (Gastropoda: Planorbidae). | Two sibling species of Biomphalaria, B. tenagophila and B. occidentalis were identified using isozyme patterns obtained by horizontal gel electrophoresis. Six diagnostic enzymatic loci were identified in digestive gland homogenates. The results enable us to distinguish the species, calculate the Nei's coefficient of ge... | ['Animals', 'Biomphalaria', 'Brazil', 'Electrophoresis, Polyacrylamide Gel', 'Electrophoresis, Starch Gel', 'Gene Frequency', 'Isoenzymes', 'Polymorphism, Genetic', 'Population Density'] | 8,544,740 | [['B01.050'], ['B01.050.500.644.400.750.185'], ['Z01.107.757.176'], ['E05.196.401.402', 'E05.301.300.319'], ['E05.196.401.485', 'E05.301.300.402'], ['G05.330'], ['D08.811.348', 'D12.776.800.300'], ['G05.365.795'], ['N01.224.600', 'N06.850.505.400.600']] | ['Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
What is the most sensitive test for diagnosing carpal tunnel syndrome? | OBJECTIVE: To compare sensitivities between 7 principal nerve conduction studies (NCS) for diagnosing carpal tunnel syndrome (CTS).METHOD: In 104 CTS and 64 control hands, following "Standard" NCSs were examined simultaneously: (1) Median sensory NCS; (2) segmental wrist-palm sensory NCS; (3) 4th digit latency differen... | ['Adult', 'Carpal Tunnel Syndrome', 'Diagnostic Techniques, Neurological', 'Electrodiagnosis', 'Female', 'Humans', 'Male', 'Median Nerve', 'Middle Aged', 'Neural Conduction', 'Sensitivity and Specificity'] | 25,504,204 | [['M01.060.116'], ['C10.668.829.500.500.200', 'C10.668.829.550.200', 'C26.844.150.206'], ['E01.370.376'], ['E01.370.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.800.720.050.500'], ['M01.060.116.630'], ['G07.265.753', 'G11.561.601'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mononuclear cells from patients with the hyper-IgE syndrome produce little IgE when they are stimulated with recombinant human interleukin-4. | To investigate whether B cells from patients with the hyper-IgE syndrome are more sensitive to the effects of interleukin-4 in vitro than B cells of normal or atopic individuals, we stimulated blood mononuclear cells (MNC) with varying doses of recombinant human interleukin 4 (rhIL-4) and measured supernatant IgE conce... | ['Adolescent', 'Adult', 'Antibodies, Monoclonal', 'Antigens, CD', 'Antigens, Differentiation, B-Lymphocyte', 'B-Lymphocytes', 'CD40 Antigens', 'Cells, Cultured', 'Child', 'Female', 'Humans', 'Hypersensitivity, Immediate', 'Immunoglobulin E', 'Interleukin-4', 'Job Syndrome', 'Leukocytes, Mononuclear', 'Lymphocyte Activa... | 1,720,150 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.051', 'D23.101.100.150'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Fumarase-deficient Uterine Leiomyomas: An Immunohistochemical, Molecular Genetic, and Clinicopathologic Study of 86 Cases. | Loss-of-function germline mutations in the fumarase (FH) gene of the Krebs cycle characterize hereditary leiomyomatosis and renal cell cancer syndrome. Fumarase (FH) deficiency can be diagnosed by the loss of immunohistochemical expression. In this study, we investigated the occurrence and clinicopathologic features of... | ['Adult', 'Aged', 'Biomarkers, Tumor', 'Female', 'Follow-Up Studies', 'Frameshift Mutation', 'Fumarate Hydratase', 'Gene Deletion', 'Humans', 'Immunohistochemistry', 'Leiomyoma', 'Leiomyosarcoma', 'Middle Aged', 'Uterine Neoplasms'] | 27,454,940 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101.140'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G05.365.590.265'], ['D08.811.520.241.300.300'], ['G05.365.590.762.320', 'G05.558.800.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
A trend analysis of the relative value of blue dye and isotope localization in 2,000 consecutive cases of sentinel node biopsy for breast cancer. | BACKGROUND: Among the advocates of blue dye, isotope, or combined dye-isotope mapping of the sentinel lymph node (SLN) for breast cancer, there is no universal consensus as to which technique is optimal and whether the relative value of each method changes with increasing experience. The objective of this study was to ... | ['Breast Neoplasms', 'Dose-Response Relationship, Radiation', 'Female', 'Humans', 'Injections, Intralesional', 'Lymph Node Excision', 'Lymph Nodes', 'Neoplasm Staging', 'Predictive Value of Tests', 'Radionuclide Imaging', 'Retrospective Studies', 'Rosaniline Dyes', 'Sentinel Lymph Node Biopsy', 'Technetium Tc 99m Sulfu... | 11,708,502 | [['C04.588.180', 'C17.800.090.500'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.430'], ['E04.446'], ['A10.549.400', 'A15.382.520.604.412'], ['E01.789.625'], ['E05.318.370.800.650', 'N05.715.36... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Diagnostic efficacy of compressed digitized real-time sonography of uterine fibroids. | RATIONALE AND OBJECTIVES: The authors investigated the diagnostic efficacy of compression of real-time ultrasound (US) examinations.METHODS: Low- and high-compression recordings (9:1 and 15:1, respectively) of examinations were generated by using Joint Photographic Experts Group algorithms. Seven radiologists used a fi... | ['Female', 'Humans', 'Leiomyoma', 'Signal Processing, Computer-Assisted', 'Ultrasonography', 'Uterine Neoplasms'] | 9,061,079 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.590.450'], ['L01.224.800'], ['E01.370.350.850'], ['C04.588.945.418.948', 'C13.351.500.852.762', 'C13.351.937.418.875']] | ['Organisms [B]', 'Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Posterior reversible encephalopathy syndrome: a report of a case with atypical features. | We report a case of a young woman presenting with profound depression of consciousness and intra-uterine death in the late stages of an unbooked pregnancy. She proceeded to develop features of cardiovascular, renal, hepatic and haematological failures. The patient was challenging to manage in view of uncertainty regard... | ['Coma', 'Female', 'Fetal Death', 'Humans', 'Magnetic Resonance Imaging', 'Posterior Leukoencephalopathy Syndrome', 'Pre-Eclampsia', 'Pregnancy', 'Pregnancy Complications', 'Prognosis', 'Tomography, X-Ray Computed', 'Young Adult'] | 18,717,659 | [['C10.597.606.358.800.200', 'C23.888.592.604.359.800.200'], ['C13.703.223', 'C23.550.260.585'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C10.228.140.631.500.500', 'C10.228.140.695.875'], ['C13.703.395.249'], ['G08.686.784.769'], ['C13.703'], ['E01.789'], ['E01.370.350.350.810', 'E01.... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Two cases of acute lymphoblastic leukemia with cytoplasmic granules]. | The presence of cytoplasmic granules in blastoid cells of patients with acute leukemia is generally accepted as a useful morphological marker for differentiation of myeloid leukemia from lymphoblastic leukemia. We diagnosed two cases of acute lymphoblastic leukemia(ALL) with cytoplasmic granulation. Surface marker anal... | ['Child', 'Cytoplasmic Granules', 'Female', 'Humans', 'Male', 'Microscopy, Electron', 'Middle Aged', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma'] | 12,166,084 | [['M01.060.406'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402', 'E05.595.402'], ['M01.060.116.630'], ['C04.557.337.428.600', 'C15.604.515.560.600', 'C20.683.515.528.600']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Valproate oral loading in the treatment of acute mania. | BACKGROUND: Evidence from earlier studies suggests that the antimanic activity of valproate becomes most pronounced within 1 to 4 days of achieving serum concentrations of 50 mg/L or greater. We conducted a prospective study to assess the onset of antimanic activity of oral loading dosages of valproate administered to ... | ['Acute Disease', 'Administration, Oral', 'Adult', 'Bipolar Disorder', 'Drug Therapy, Combination', 'Female', 'Hospitalization', 'Humans', 'Lorazepam', 'Male', 'Prospective Studies', 'Psychiatric Status Rating Scales', 'Valproic Acid'] | 8,253,698 | [['C23.550.291.125'], ['E02.319.267.100'], ['M01.060.116'], ['F03.084.500'], ['E02.319.310'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.079.080.070.450'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['F04.711.513.653... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Noninvasive quantitation of right-ventricular volume overload in adults by gated equilibrium radionuclide angiography. | R-wave-synchronized equilibrium radionuclide angiography (RNA) is a noninvasive method whose time-activity curves provide count information that is proportional to ventricular volume. We have performed resting gated RNA in nine consecutive adult patients undergoing cardiac catheterization for evaluation of left-to-righ... | ['Adult', 'Aged', 'Cardiac Volume', 'Heart Septal Defects, Atrial', 'Humans', 'Middle Aged', 'Radionuclide Imaging', 'Stroke Volume'] | 7,131,087 | [['M01.060.116'], ['M01.060.116.100'], ['G09.330.380.249'], ['C14.240.400.560.375', 'C14.280.400.560.375', 'C16.131.240.400.560.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.710', 'E01.370.384.730'], ['E01.370.370.380.150.700', 'G09.330.380.124.882']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Maternal serum insulin-like growth factor (IGF-I) and binding proteins IGFBP-1 and IGFBP-3 at 11-13 weeks' gestation in pregnancies delivering small for gestational age neonates. | OBJECTIVE: To investigate the possible value of maternal serum concentration of insulin-like growth factor-I (IGF-I), IGF binding protein-1 (IGFBP-1) and IGFBP-3 at 11-13 weeks' gestation in the prediction of small-for-gestational age (SGA) neonates.STUDY DESIGN: Maternal serum concentrations of IGF-I, IGFBP-1 and IGFB... | ['Adult', 'Biomarkers', 'Female', 'Humans', 'Infant, Newborn', 'Infant, Small for Gestational Age', 'Insulin-Like Growth Factor Binding Protein 1', 'Insulin-Like Growth Factor Binding Protein 3', 'Insulin-Like Growth Factor I', 'Pregnancy', 'Pregnancy Trimester, First'] | 22,245,615 | [['M01.060.116'], ['D23.101'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.460.560'], ['D12.776.157.420.250'], ['D12.776.157.420.270'], ['D12.644.276.937.400', 'D12.776.124.862.400', 'D12.776.467.937.400', 'D23.529.937.400'], ['G08.686.784.769'], ['G08.686.707.408']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Chemical composition and antioxidant activity of Phlomis leucophracta | The chemical composition, and antioxidant activity of the essential oils of the endemic Phlomis leucophracta P. H. Davis et Hub.-Mor. was investigated. The major compounds of the essential oil were linalool (36.4%), spathulenol (8.4%) and caryophyllene oxide (8.4%). The composition of the oil differs with published dat... | ['Acyclic Monoterpenes', 'Antioxidants', 'Gas Chromatography-Mass Spectrometry', 'Oils, Volatile', 'Phlomis', 'Polycyclic Sesquiterpenes', 'Sesquiterpenes', 'Turkey'] | 30,417,666 | [['D02.455.849.575.125'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['E05.196.181.349.500', 'E05.196.566.500'], ['D10.627.675'], ['B01.650.940.800.575.912.250.583.520.750'], ['D02.455.849.765.674', 'D04.663'], ['D02.455.849.765'], ['Z01.252.245.500.850']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Cell cycle stage-specific accumulation of mRNAs encoding tubulin and other polypeptides in Chlamydomonas. | The accumulation pattern of a number of mRNAs during the cell cycle of Chlamydomonas was examined by two-dimensional gel analysis of in vitro translation products and by RNA blot hybridization analysis. Two-dimensional gel analysis revealed that 10-15% of the 300 most abundant translation products are differentially sy... | ['Cell Cycle', 'Chlamydomonas', 'Cloning, Molecular', 'DNA', 'Kinetics', 'Nucleic Acid Hybridization', 'Peptides', 'Poly A', 'Protein Biosynthesis', 'RNA', 'RNA, Messenger', 'Tubulin'] | 6,182,565 | [['G04.144'], ['B01.650.940.150.385'], ['E05.393.220'], ['D13.444.308'], ['G01.374.661', 'G02.111.490'], ['E05.393.661', 'G02.111.611'], ['D12.644'], ['D13.695.578.550.500'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['D13.444.735'], ['D13.444.735.544'], ['D05.750.078.734.800', 'D12.776.220.600.800', 'D12.776.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities. | Cytogenetic findings in a few primary effusion lymphoma (PEL) cell lines have been reported, but only three complete karyotypes of primary specimens from patients with this neoplasm have been published. In this study, cytogenetic analysis was performed on 11 effusion specimens from 10 patients with PEL. We corroborate ... | ['Adult', 'Antigens, CD', 'Ascitic Fluid', 'Biomarkers', 'Chromosomes, Human, Pair 1', 'Chromosomes, Human, Pair 7', 'Genotype', 'Herpesvirus 8, Human', 'Humans', 'Immunophenotyping', 'Karyotyping', 'Lymphoma, AIDS-Related', 'Lymphoma, B-Cell', 'Male', 'Middle Aged', 'Trisomy'] | 11,841,403 | [['M01.060.116'], ['D23.050.301.264.035', 'D23.101.100.110'], ['A12.207.119'], ['D23.101'], ['A11.284.187.520.300.235.240', 'G05.360.162.520.300.235.240'], ['A11.284.187.520.300.325.335', 'G05.360.162.520.300.325.335'], ['G05.380'], ['B04.280.210.400.700.330', 'B04.280.382.400.700.330', 'B04.613.204.500.700.330'], ['B0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Two cases of misaligned deployment of Valiant Captivia thoracic stent graft. | Thoracic aortic stent grafts have been widely used. We report two cases of proximal misaligned deployment of the Valiant Captivia stent graft after hybrid treatment of thoracic aneurysms. This complication has, to our knowledge, never been previously reported in the literature with this stent graft. We discuss the vari... | ['Aged', 'Aortic Aneurysm, Thoracic', 'Blood Vessel Prosthesis Implantation', 'Humans', 'Male', 'Prosthesis Design', 'Stents'] | 22,857,811 | [['M01.060.116.100'], ['C14.907.055.239.125', 'C14.907.109.139.125'], ['E04.100.814.868.500', 'E04.650.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.320.550', 'E07.695.680'], ['E07.695.750']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluating the impact of a home-based rehabilitation service on older people and their caregivers: a matched-control quasi-experimental study. | Introduction: Previous studies evaluating home-based rehabilitation service (HBRS) merely focused on the period immediately after the patients' discharge from hospitals. The present study focuses on HBRS that covers clients who have not been recently hospitalized. HBRS aims to meet older clients' rehabilitation needs a... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Caregivers', 'Case-Control Studies', 'Female', 'Home Care Services, Hospital-Based', 'Hong Kong', 'Humans', 'Independent Living', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Patient Discharge', 'Quality of Life', 'Rehabilitation Research'] | 30,254,432 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['N02.421.143.524.403'], ['Z01.252.474.164.450'], ['B01.050.150.900.649.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
A simplified agarose gel electrophoresis for rotavirus detection. | The use of agarose gel electrophoresis for rotavirus detection is a suitable routine method if simplifying modifications are introduced. Incorporation of ethidium bromide into the agarose gel permits its use for several times in the course of one week without further staining of the RNA segments. The electrophoresis ch... | ['Child', 'Electrophoresis, Agar Gel', 'Feces', 'Humans', 'Latex Fixation Tests', 'Rotavirus Infections'] | 1,520,972 | [['M01.060.406'], ['E05.196.401.153', 'E05.301.300.100'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812.735.050.450', 'E05.200.812.735.050.450', 'E05.478.594.760.050.450'], ['C01.925.782.791.814']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Calnexin is a novel sero-diagnostic marker for lung cancer. | To develop sero-diagnostic markers for lung cancer, we generated monoclonal antibodies using lung adenocarcinoma (AC)-derived A549 cells as antigens by employing the random immunization method. Hybridoma supernatants were immunohistochemically screened for antibodies with AMeX-fixed and paraffin-embedded A549 cell prep... | ['Adenocarcinoma', 'Adenocarcinoma of Lung', 'Aged', 'Antibodies, Monoclonal', 'Antigens, Neoplasm', 'Biomarkers, Tumor', 'Calnexin', 'Cell Line, Tumor', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Protein Array Analysis'] | 26,344,721 | [['C04.557.470.200.025'], ['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['M01.060.116.100'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.285'], ['D23.101.140'], ['D12.644.360.372.311', 'D12.776.157.125.412.311', 'D12.776.476.387.311', 'D12.776.503.2... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Action potential alternans in LQT3 syndrome: a simulation study. | The long QT syndrome type-3 (LQT3) is an inherited cardiac disorder caused by mutations in the sodium channel gene SCN5A. LQT3 has been associated with ventricular arrhythmias and sudden cardiac death, specially at low heart rates. Based on computer simulations and experimental investigations, analysis of the morpholog... | ['Action Potentials', 'Genetic Diseases, Inborn', 'Heart', 'Humans', 'Long QT Syndrome', 'Models, Cardiovascular', 'Muscle Proteins', 'Mutation', 'NAV1.5 Voltage-Gated Sodium Channel', 'Sodium Channels'] | 18,002,037 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['C16.320'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.067.565', 'C14.280.123.625', 'C16.131.240.400.715', 'C23.550.073.547'], ['E05.599.395.161'], ['D12.776.210.500'], ['G05.365.590'], ['D12.776.157.530.400.875.750.500', 'D12.776.543... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro and in vivo assessment of the bioavailability of potassium from a potassium tartrate tablet. | The bioavailability of potassium from orally administered potassium tartrate was evaluated in 20 normal subjects under metabolic balance conditions. Subjects were given 34 mmol potassium (5 tablets of Cal-K) as a divided dose on each of 2 consecutive days. Urinary excretion of potassium, as determined from 24-h urinary... | ['Adult', 'Biological Availability', 'Creatinine', 'Female', 'Gastric Acid', 'Humans', 'Hydrogen-Ion Concentration', 'Intestine, Small', 'Male', 'Potassium', 'Sodium', 'Solubility', 'Tablets', 'Tartrates'] | 2,059,671 | [['M01.060.116'], ['G03.787.151', 'G07.690.725.129'], ['D03.383.129.308.207'], ['A12.200.307.603'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['A03.556.124.684'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', '... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Differences in frequency of the deletion polymorphism of the angiotensin-converting enzyme gene in different ethnic groups. | A polymorphism characterized by the insertion or deletion of a 287-bp Alu repeat sequence in intron 16 of the angiotensin-converting enzyme gene determines about half the serum angiotensin-converting enzyme level variability among individuals. The deletion polymorphism is associated with higher levels of angiotensin-co... | ['Adult', 'African Continental Ancestry Group', 'Chi-Square Distribution', 'European Continental Ancestry Group', 'Female', 'Gene Deletion', 'Humans', 'Indians, North American', 'Male', 'Middle Aged', 'Myocardial Ischemia', 'Peptidyl-Dipeptidase A', 'Polymerase Chain Reaction', 'Polymorphism, Genetic', 'Probability', '... | 11,437,027 | [['M01.060.116'], ['M01.686.508.100'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['M01.686.508.400'], ['G05.365.590.762.320', 'G05.558.800.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.686.508.150.600'], ['M01.060.116.630'], ['C14.280.647', 'C14.907.58... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Cross-national associations between parent and peer communication and psychological complaints. | OBJECTIVES: To assess whether or not communication with parents and with peers is related to experiencing psychological complaints in an attempt to explore the hypotheses of continuity and compensation or moderation between contexts.METHODS: Questions on communication with their parents and peers, as well as on the fre... | ['Adolescent', 'Child', 'Cluster Analysis', 'Communication', 'Europe', 'Female', 'Humans', 'Internationality', 'Male', 'North America', 'Parent-Child Relations', 'Peer Group', 'Stress, Psychological', 'Surveys and Questionnaires'] | 19,639,255 | [['M01.060.057'], ['M01.060.406'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['F01.145.209', 'L01.143'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615'], ['Z01.107.567'], ['F01.829.263.370.290'], ['F01.829.316.483'], ['F01.145.126.990', 'F02.830.900'], ['E05.318.308.98... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Safety of a tetanus-diphtheria-acellular pertussis vaccine when used off-label in an elderly population. | BACKGROUND: Published data on the safety of tetanus-diphtheria-acellular pertussis vaccine (Tdap) in persons aged ?65 years are limited. This study aims to examine a large cohort of Tdap users ?65 years for evidence of increased risk of adverse events following vaccination.METHODS: A matched cohort study design and a s... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Cohort Studies', 'Diphtheria', 'Diphtheria-Tetanus-acellular Pertussis Vaccines', 'Humans', 'Off-Label Use', 'Tetanus', 'Time Factors', 'United States', 'Vaccination', 'Vaccines, Acellular', 'Whooping Cough'] | 23,196,953 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C01.150.252.410.040.246.388'], ['D20.215.894.135.535.295', 'D20.215.894.691.263.290', 'D20.215.894.691.824.290', 'D20.215.894.815.149', 'D20.215.894.860... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Policy progress for physician treatment of opiate addiction. | Medical treatment of heroin addiction with methadone and other pharmacotherapies has important benefits for individuals and society. However, regulatory policies have separated this treatment from the medical care system, limiting access to care and contributing to the social stigma of even effective addiction pharmaco... | ['Buprenorphine', 'Humans', 'Methadone', 'Narcotic Antagonists', 'Opioid-Related Disorders', 'Physicians, Family', 'Public Policy', 'Substance Abuse Treatment Centers', 'United States'] | 12,047,733 | [['D03.132.577.249.150', 'D03.605.497.150', 'D03.633.400.686.150', 'D04.615.723.795.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.522.675'], ['D27.505.696.543', 'D27.505.696.663.850.512', 'D27.505.954.427.550'], ['C25.775.643.500', 'F03.900.647.500'], ['M01.526.485.810.770', 'N02.360.810.770'], ['I01.65... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Mastitis today: incidence, prevention and treatment. | The study concerned 664 women of South-West Finland, and they were studied 5-12 weeks after delivery. The total frequency of mastitis in this population was much higher than generally reported in literature, 24% as opposed to 3%. The frequency of mastitis was similar among nulli- and multiparous women. The diagnosis wa... | ['Adolescent', 'Adult', 'Anti-Bacterial Agents', 'Breast Feeding', 'Exercise', 'Female', 'Humans', 'Massage', 'Mastitis', 'Middle Aged', 'Puerperal Infection', 'Retrospective Studies', 'Risk Factors', 'Staphylococcal Infections'] | 8,092,782 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.122.085'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.599.750.750', 'E02.779.867.880.750', 'E02.831.535.867.880.750'], ['C13.703.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Protooncogene expression in normal and psoriatic skin. | The expression of the c-myc, c-fos, c-jun, c-erbB, and c-Ha-ras protooncogenes was compared by Northern blot analysis of total RNA extracted from keratome biopsies of normal skin and psoriatic plaques. Isolation of intact RNA from frozen tissue required careful attention to technique during the early stages of extracti... | ['Epidermis', 'Gene Expression Regulation', 'Humans', 'Organ Culture Techniques', 'Proto-Oncogenes', 'Psoriasis', 'RNA', 'Reference Values', 'Skin', 'Skin Physiological Phenomena', 'Transcription, Genetic'] | 1,688,596 | [['A10.272.497', 'A17.815.250'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481.500.484'], ['G05.360.340.024.340.375.500.791'], ['C17.800.859.675'], ['D13.444.735'], ['E05.978.810'], ['A17.815'], ['G13.750'], ['G02.111.873', 'G05.297.700']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. | BACKGROUND: Genome-wide association studies (GWAS) have identified consistent associations with obesity. However, the mechanisms remain unclear.OBJECTIVE: The objective was to determine the association between obesity susceptibility loci and dietary intake.DESIGN: The association of GWAS-identified obesity risk alleles... | ['Alleles', 'Dairy Products', 'Diabetes Mellitus, Type 2', 'Diet', 'Diet Surveys', 'Dietary Proteins', 'Energy Intake', 'Feeding Behavior', 'Female', 'Genetic Loci', 'Genetic Predisposition to Disease', 'Humans', 'Male', 'Middle Aged', 'Obesity', 'Risk Factors', 'Surveys and Questionnaires'] | 22,513,296 | [['G05.360.340.024.340.030'], ['G07.203.300.350', 'J02.500.350'], ['C18.452.394.750.149', 'C19.246.300'], ['G07.203.650.240'], ['E05.318.308.980.485.350', 'N05.715.360.300.800.469.300', 'N06.850.505.616.300', 'N06.850.520.308.980.469.350'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G07.203.650.240.340'], ['F... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Subarachnoid Hemorrhage as Result of Retrocorporeal Artery Aneurysm Rupture: Rare Sequel of Subclavian Steal Syndrome. | BACKGROUND: Subclavian steal phenomenon can cause retrograde flow in the vertebral artery as a result of ipsilateral occlusion of the subclavian artery. This phenomenon has various clinical presentations, such as claudication of the affected extremity or intermittent vertebrobasilar ischemia. Aneurysm formation in the ... | ['Aneurysm, Ruptured', 'Computed Tomography Angiography', 'Endovascular Procedures', 'Headache', 'Humans', 'Male', 'Middle Aged', 'Neck Pain', 'Subarachnoid Hemorrhage', 'Subclavian Steal Syndrome', 'Treatment Outcome'] | 31,574,332 | [['C14.907.055.185'], ['E01.370.350.350.810.335', 'E01.370.350.567.250', 'E01.370.350.600.350.700.810.335', 'E01.370.350.700.700.810.335', 'E01.370.350.700.810.810.568', 'E01.370.350.825.810.810.499'], ['E04.100.814.529', 'E04.502.382'], ['C23.888.592.612.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.06... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A national survey of pediatrician knowledge and attitudes regarding human papillomavirus vaccination. | OBJECTIVE: A human papillomavirus vaccine was licensed in June 2006. The vaccine is quadrivalent, protecting against 2 human papillomavirus strains that cause cervical cancer and 2 that cause genital warts. The objective of this study was to determine physician characteristics, knowledge, and attitudes associated with ... | ['Attitude of Health Personnel', 'Child', 'Cross-Sectional Studies', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Papillomavirus Infections', 'Pediatrics', 'Surveys and Questionnaires', 'Vaccination'] | 17,142,510 | [['F01.100.050', 'N05.300.100'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C01.925.256.650', 'C01.925.928.725'], ['H02.403.670'], ['E05.318.308.980', 'N05... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Binding Free Energies of Host-Guest Systems by Nonequilibrium Alchemical Simulations with Constrained Dynamics: Illustrative Calculations and Numerical Validation. | In the companion article (Giovannelli et al., 10.1021/acs.jctc.7b00594), we presented an alchemical approach, based on nonequilibrium molecular dynamics simulations, to compute absolute binding free energies of a generic host-guest system. Two alternative computational routes, called binded-domain and single-point alch... | ['Anions', 'Ligands', 'Molecular Dynamics Simulation', 'Thermodynamics', 'Zinc', 'beta-Cyclodextrins'] | 29,112,430 | [['D01.248.497.158'], ['D27.720.470.480'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['G01.906'], ['D01.268.556.940', 'D01.268.956.906', 'D01.552.544.940'], ['D04.345.103.333', 'D09.301.915.400.375.333', 'D09.698.365.855.400.375.333']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Tissue expander causing iatrogenic difficult intubation. | Difficulty during tracheal intubation may occur due to a number of anatomical factors and pathological conditions. These factors may be influenced by earlier surgical manoeuvres, so that difficulty may occasionally be encountered at subsequent operation. One such case of 'iatrogenic' difficulty, where a tissue expander... | ['Adolescent', 'Female', 'Humans', 'Intubation, Intratracheal', 'Neck', 'Surgery, Plastic', 'Tissue Expansion Devices'] | 9,038,458 | [['M01.060.057'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['A01.598'], ['H02.403.810.788'], ['E07.695.800', 'E07.858.886']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Mesenteric panniculitis. Part 1: MDCT--pictorial review. | Mesenteric panniculitis is an uncommon benign inflammatory condition of unknown etiology that involves the adipose tissue of the mesentery and for which an extremely varied terminology has been used, causing considerable confusion. It can be evaluated as a single disease with two pathological subgroups: Mesenteric Pann... | ['Diagnosis, Differential', 'Fat Necrosis', 'Fibrosis', 'Humans', 'Panniculitis, Peritoneal', 'Tomography, X-Ray Computed'] | 22,191,287 | [['E01.171'], ['C23.550.717.365'], ['C23.550.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.844.600', 'C17.300.710.600'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prognostic Significance of Serum CEA for Non-small Cell Lung Cancer Patients Receiving Stereotactic Body Radiotherapy. | BACKGROUND/AIM: To examine the prognostic significance of serum carcinoembryonic antigen (CEA) for stage I non-small cell lung cancer (NSCLC) treated with stereotactic body radiotherapy (SBRT).PATIENTS AND METHODS: In total, 129 stage I NSCLC patients were analyzed and divided into two groups: CEA-High (CEA>5 ng/ml) an... | ['Aged', 'Aged, 80 and over', 'Carcinoembryonic Antigen', 'Carcinoma, Non-Small-Cell Lung', 'Disease-Free Survival', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Prognosis', 'Radiosurgery', 'Tumor Burden'] | 28,870,949 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. | UNLABELLED: Silver sulfadiazine (AgSD) is a topical antibiotic with limited aqueous solubility. In this study, it was shown that poly(amido amine) (PAMAM) dendrimer complexes with SD (SDZ) and silver (Ag) could be used for a bottom-up approach to synthesize highly-soluble AgSD nanoparticles (NPs). These NPs were stabil... | ['Anti-Bacterial Agents', 'Dendrimers', 'Metal Nanoparticles', 'Microscopy, Electron, Scanning', 'Particle Size', 'Polyamines', 'Silver'] | 22,470,054 | [['D27.505.954.122.085'], ['D05.750.327', 'E02.319.300.380.200', 'J01.637.512.600.200'], ['J01.637.512.600.500'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['G02.712'], ['D02.092.782'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Coronary vascular responses to chemical stimulation of abdominal visceral organs. | Topical application of bradykinin or capsaicin to abdominal visceral organs produces adrenergically mediated, reflex increases in mean arterial pressure and cardiac work. To determine the effects on coronary blood flow, the left main coronary artery of anesthetized cats was perfused at constant pressure with a servo-co... | ['Animals', 'Blood Pressure', 'Bradykinin', 'Capsaicin', 'Cats', 'Coronary Circulation', 'Coronary Vessels', 'Female', 'Gallbladder', 'Heart Rate', 'Male', 'Myocardium', 'Oxygen Consumption', 'Perfusion', 'Phentolamine', 'Propranolol', 'Reference Values', 'Reflex', 'Stomach'] | 2,923,235 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D12.644.276.812.169', 'D12.644.400.090', 'D12.644.456.193', 'D12.776.467.812.169', 'D12.776.631.650.090', 'D23.469.050.375.110', 'D23.529.812.169'], ['D02.065.690.500', 'D02.455.326.271.690.222', 'D02.455.426.559.389.657.166.099', 'D03.132.760.200', 'D10.251.3... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Considerations for using a geographic information system to assess environmental supports for physical activity. | The use of a geographic information system (GIS) to study environmental supports for physical activity raises several issues, including acquisition and development, quality, and analysis. We recommend to public health professionals interested in using GIS that they investigate available data, plan for data development ... | ['Crime', 'Data Collection', 'Environment', 'Geographic Information Systems', 'Humans', 'Motor Activity', 'Public Facilities', 'Recreation', 'Research Personnel', 'Safety', 'Schools', 'Social Environment', 'South Carolina', 'Surveys and Questionnaires', 'Time Factors', 'Transportation'] | 15,670,452 | [['I01.198.240', 'I01.880.735.191'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['G16.500.275', 'N06.230'], ['L01.313.500.750.300.314', 'L01.470.750.750.462'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698'], ['J03.720'], ['I03.450.642'], ['M01.526.839'], [... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Named Grou... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
Suramin interference with transforming growth factor-beta inhibition of human renal cell carcinoma in culture. | Suramin is a polyanionic compound used clinically for the treatment of trypanosomiasis, which is known to inhibit the action of many protein factors in vitro. Transforming growth factor-beta (TGF-beta) is a multifunctional regulatory protein which inhibits the growth of renal cell carcinoma in culture. While suramin at... | ['Carcinoma, Renal Cell', 'Cell Division', 'Dose-Response Relationship, Drug', 'Humans', 'Kidney Neoplasms', 'Suramin', 'Transforming Growth Factor beta', 'Tumor Cells, Cultured'] | 1,405,609 | [['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Bicavitary cardiac stimulation. Re-assessment and results]. | In each indication for cardiac stimulation, dual chamber pacing must be considered if stimulation or sensing in the atrium is possible. It is of particular importance in patients with diastolic ventricular dysfunction. The Heart rate is the most important parameter in stress-adaptation; for this reason we propose to us... | ['Adaptation, Physiological', 'Arrhythmias, Cardiac', 'Cardiac Pacing, Artificial', 'Heart Rate', 'Hemodynamics', 'Humans', 'Quality of Life', 'Syncope'] | 1,604,292 | [['G07.025', 'G16.012.500'], ['C14.280.067', 'C23.550.073'], ['E02.331.200'], ['E01.370.600.875.500', 'G09.330.380.500'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['C10.597.606.358.800.600', 'C23.888.592.604.359.800.600']] | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Fryns syndrome: a rare familial cause of congenital diaphragmatic hernia. | Fryns syndrome is a rare autosomal recessive disorder characterized by diaphragmatic hernia and multiple anomalies. Almost all infants have died at birth, and survivors have had severe mental retardation. The authors report on a family in which three children had diaphragmatic hernia diagnosed prenatally. The first chi... | ['Abnormalities, Multiple', 'Abortion, Eugenic', 'Adult', 'Child, Preschool', 'Fatal Outcome', 'Female', 'Genetic Counseling', 'Hernia, Diaphragmatic', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Pregnancy', 'Pregnancy Trimester, Second', 'Syndrome', 'Ultrasonography, Prenatal'] | 7,807,364 | [['C16.131.077'], ['E04.520.050.050'], ['M01.060.116'], ['M01.060.406.448'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['H01.158.273.343.385.500.384', 'N02.421.308.400'], ['C23.300.707.960.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Induction of ascorbate peroxidase and glutathione reductase activities by interactions of mixtures of air pollutants. | The response of ascorbate peroxidase and glutathione reductase activities in peas (Pisum sativum var. Waverex) was investigated after three weeks of exposure to mixed fumigations with SO2, NO2 and O3 (0.050 parts per million each) and increasing concentrations of O3 (0-0.150 parts per million). The results show that pl... | ['Air Pollutants', 'Ascorbate Peroxidases', 'Enzyme Induction', 'Fabaceae', 'Fumigation', 'Glutathione Reductase', 'Nitrogen Dioxide', 'Ozone', 'Peroxidases', 'Plants, Medicinal', 'Sulfur Dioxide'] | 3,508,431 | [['D27.888.284.101'], ['D08.811.682.732.165'], ['G05.308.320.200'], ['B01.650.940.800.575.912.250.401'], ['N06.850.780.200.300'], ['D08.811.682.667.092'], ['D01.362.635.600', 'D01.625.550.525', 'D01.650.550.587.625'], ['D01.362.670.600'], ['D08.811.682.732'], ['B01.650.560'], ['D01.362.810', 'D01.650.550.850.925', 'D01... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells. | Translation and mRNA degradation are intimately connected, yet the mechanisms that link them are not fully understood. Here, we studied these mechanisms in embryonic stem cells (ESCs). Transcripts showed a wide range of stabilities, which correlated with their relative translation levels and that did not change during ... | ['Animals', 'Cell Differentiation', 'DEAD-box RNA Helicases', 'Embryonic Stem Cells', 'Gene Knockout Techniques', 'Humans', 'Mice', 'MicroRNAs', 'Peptide Chain Termination, Translational', 'Protein Biosynthesis', 'Protein Processing, Post-Translational', 'Proto-Oncogene Proteins', 'RNA Stability', 'RNA-Binding Proteins... | 30,044,225 | [['B01.050'], ['G04.152'], ['D08.811.913.696.445.735.720.249'], ['A11.872.700.250'], ['E05.393.335.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['G02.111.660.871.720', 'G03.734.871.720'], ['G02... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.