Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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The farnesyltransferase â-subunit RAM1 regulates localization of RAS proteins and appressorium-mediated infection in Magnaporthe oryzae. | Post-translational farnesylation can regulate subcellular localization and protein-protein interaction in eukaryotes. The function of farnesylation is not well identified in plant pathogenic fungi, particularly during the process of fungal infection. Here, through functional analyses of the farnesyltransferase â-subuni... | ['Farnesyltranstransferase', 'Fungal Proteins', 'Gene Expression Regulation, Fungal', 'Magnaporthe', 'Plant Diseases', 'Quinolones', 'Signal Transduction', 'Spores, Fungal', 'Virulence', 'ras Proteins'] | 31,250,536 | [['D08.811.913.225.437'], ['D12.776.354'], ['G05.308.330'], ['B01.300.107.575'], ['G15.610'], ['D03.633.100.810.835'], ['G02.111.820', 'G04.835'], ['A11.870.710', 'A19.374.500', 'B05.775.710'], ['G06.930'], ['D08.811.277.040.330.300.400.500', 'D12.644.360.525.500', 'D12.776.157.325.515.500', 'D12.776.476.525.500']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Observation of snakebite victims: is twelve hours still necessary? | OBJECTIVE: To determine the period of observation required to exclude elapid envenoming following presentation with suspected or definite snakebite in South-east Queensland.METHODS: Two part case series of patients presenting with a snakebite to a regional hospital in South-east Queensland. A snakebite assessment proto... | ['Animals', 'Elapidae', 'Humans', 'Observation', 'Prospective Studies', 'Queensland', 'Retrospective Studies', 'Snake Bites', 'Time Factors'] | 14,992,069 | [['B01.050'], ['B01.050.150.900.833.672.125.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581.249'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['Z01.639.100.937', 'Z01.678.100.373.937'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Anti-T-lymphocyte globulin treatment in inclusion body myositis: a randomized pilot study. | The authors performed an open, randomized trial in patients with inclusion body myositis comparing 1) 12-month treatment with oral methotrexate 7.5 mg/week alone (MTX group) with 2) 12-month MTX treatment preceded by 7 days of IV anti-T-lymphocyte immunoglobulin treatment (ATG group). Eleven patients were randomized; 1... | ['Aged', 'Aged, 80 and over', 'Antilymphocyte Serum', 'Autoimmune Diseases', 'Female', 'Humans', 'Immunosuppressive Agents', 'Male', 'Methotrexate', 'Muscle Contraction', 'Myositis, Inclusion Body', 'Pilot Projects', 'Prospective Studies', 'T-Lymphocytes', 'Treatment Outcome'] | 12,874,415 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A12.207.152.846.500.203', 'D12.776.124.486.485.114.573.203', 'D12.776.124.790.651.114.573.203', 'D12.776.377.715.548.114.573.203', 'D20.215.401.203'], ['C20.111'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['D03.633.100.733.631.192.500'], ... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Extremely well-differentiated adenocarcinoma ("adenoma malignum") of the cervix in a patient with Peutz-Jeghers syndrome. | In a 29-year-old woman with the Peutz-Jeghers syndrome (PJS), an extremely well differentiated adenocarcinoma (adenoma malignum) of the uterine cervix was detected. The cervical lesion consisted of a polypoid mass, measuring 3.5 cm in greatest diameter, composed of extremely well differentiated tubules resembling those... | ['Adenocarcinoma', 'Adult', 'Antibiotics, Antineoplastic', 'Biopsy', 'Carcinoembryonic Antigen', 'Cervix Uteri', 'Colon', 'Drug Therapy, Combination', 'Female', 'Follow-Up Studies', 'Humans', 'Hysterectomy', 'Peutz-Jeghers Syndrome', 'Rectum', 'Sigmoidoscopy', 'Uterine Cervical Neoplasms'] | 4,055,223 | [['C04.557.470.200.025'], ['M01.060.116'], ['D27.505.954.248.106'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Biochemical variation of human Ia like antigens detected with monoclonal antibodies. | Four mouse monoclonal antibodies to human B cell surface determinants previously described as being directed against Ia like (MHC class II) antigens, have been shown to precipitate Ia alpha and beta chains. Electrophoretic transfer experiments showed one antibody to be directed against Ia alpha chains and two others to... | ['Antibodies, Monoclonal', 'Antigens, Surface', 'B-Lymphocytes', 'Cell Line', 'Chemical Precipitation', 'Electrophoresis, Polyacrylamide Gel', 'Epitopes', 'Histocompatibility Antigens Class II', 'Humans', 'Peptides', 'T-Lymphocytes'] | 6,191,895 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A11.251.210'], ['E05.196.150', 'G02.159'], ['E05.196.401.402', 'E05.301.300.319'], [... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Short-term exposure to air pollution in a road tunnel enhances the asthmatic response to allergen. | The aim of this study was to assess whether air pollution in road tunnels would promote asthmatic reactions in persons with mild allergic asthma. Twenty volunteers with mild allergic asthma were exposed, inside a car, for 30 min in a Stockholm city road tunnel. As a control, the subjects were exposed to much lower poll... | ['Adult', 'Air Pollutants', 'Airway Resistance', 'Asthma', 'Automobile Driving', 'Environmental Exposure', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nitric Oxide', 'Plethysmography', 'Reference Values', 'Respiratory Function Tests', 'Sensitivity and Specificity', 'Statistics, Nonparametric', 'Time Factors', 'Vehicle ... | 10,780,764 | [['M01.060.116'], ['D27.888.284.101'], ['E01.370.386.700.050', 'G09.772.060'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['I03.125'], ['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Obtaining consumer perspectives using a citizens' jury: does the current country of origin labelling in Australia allow for informed food choices? | BACKGROUND: Contemporary food systems are vast and complex, creating greater distance between consumers and their food. Consequently, consumers are required to put faith in a system of which they have limited knowledge or control. Country of origin labelling (CoOL) is one mechanism that theoretically enables consumer k... | ['Adolescent', 'Adult', 'Aged', 'Choice Behavior', 'Community Participation', 'Consumer Behavior', 'Female', 'Food Labeling', 'Food Preferences', 'Humans', 'Male', 'Middle Aged', 'Nutrition Policy', 'Qualitative Research', 'Research Design', 'South Australia', 'Young Adult'] | 27,938,403 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F02.463.785.373.346'], ['N02.421.143.212', 'N03.540.245.360'], ['F01.145.236'], ['J01.576.423.850.600.400', 'J01.576.761.400.450'], ['F01.145.407.516', 'G07.203.650.353.516'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I01.655.500.60... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
Alpha-adrenoceptor involvement in swim stress-induced antinociception in the mouse. | Three different intensities of swim stress produced stress-induced antinociception (SIA) in mice which was assessed either by the reduction in the number of abdominal constrictions produced by acetic acid or by an increase in reaction time on a hot-plate. The involvement of alpha-adrenoceptors in the three models of SI... | ['Adrenergic alpha-Antagonists', 'Analgesia', 'Animals', 'Brain', 'Drug Interactions', 'Male', 'Mice', 'Norepinephrine', 'Pain Measurement', 'Physical Exertion', 'Receptors, Adrenergic, alpha', 'Stress, Physiological', 'Swimming'] | 1,982,301 | [['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['E03.091'], ['B01.050'], ['A08.186.211'], ['G07.690.773.968'], ['B01.050.150.900.649.313.992.635.505.500'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', 'D02.092.311.830', 'D02.455.426.559.389.657.166.175.830'], ['E01.370.600.550.324... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Long-Range Hairpin Slippage Reconfiguration Dynamics in Trinucleotide Repeat Sequences. | Trinucleotide repeat (TNR) sequences, which are responsible for several neurodegenerative genetic diseases, fold into hairpins that interfere with the protein machinery in replication or repair, thus leading to dynamic mutation -abnormal expansions of the genome. Despite their high thermodynamic stability, these hairpi... | ['DNA', 'Molecular Dynamics Simulation', 'Monte Carlo Method', 'Nucleic Acid Conformation', 'Thermodynamics', 'Trinucleotide Repeats'] | 31,241,956 | [['D13.444.308'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['G02.111.570.820.486', 'G05.360.580'], ['G01.906'], ['G02.111.570.080.708.800.500.850', 'G05.360.080.708.800.500.850', 'G05.360.340.024.850.500.850']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Plasma phospholipid transfer protein enhances transfer and exchange of phospholipids between very low density lipoproteins and high density lipoproteins during lipolysis. | In order to determine the effects of a plasma phospholipid transfer protein on the transfer of phospholipids from very low density lipoproteins (VLDL) to high density lipoproteins (HDL) during lipolysis, biosynthetically labeled rat 32P-labeled VLDL was incubated with human HDL3 and bovine milk lipoprotein lipase (LPL)... | ['Animals', 'Carrier Proteins', 'Humans', 'Lipid Mobilization', 'Lipoproteins, HDL', 'Lipoproteins, VLDL', 'Membrane Proteins', 'Phospholipid Transfer Proteins', 'Phospholipids', 'Rats'] | 4,031,662 | [['B01.050'], ['D12.776.157'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.458.500.500'], ['D10.532.432', 'D12.776.521.479'], ['D10.532.599', 'D12.776.521.622'], ['D12.776.543'], ['D12.776.157.674', 'D12.776.543.693'], ['D10.570.755'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of two different kinds of quilt on human core temperature during night sleep. | Effects of two kinds of quilt with different thermal insulation properties between the upper and lower halves on human core temperature during night sleep were compared at an ambient temperature of 16 degrees C and a relative humidity of 50% in five healthy adult women. One quilt has a thick part (110 mm) in the upper ... | ['Adult', 'Bedding and Linens', 'Body Temperature', 'Female', 'Humans', 'Sleep'] | 8,206,053 | [['M01.060.116'], ['E07.325.137', 'J01.494.221'], ['E01.370.600.875.374', 'G07.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.830.855', 'G11.561.803']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Effects of Asp residues near the L-side pigments in bacterial reaction centers. | The primary photochemistry in Rhodobacter capsulatus reaction centers (RCs) containing the Phe to Asp mutation at L polypeptide residue 121 near the photoactive bacteriopheophytin (BPhL) is characterized using ultrafast transient absorption spectroscopy. At 285 K, initial charge separation from P* proceeds with essenti... | ['Aspartic Acid', 'Kinetics', 'Light-Harvesting Protein Complexes', 'Mutagenesis, Site-Directed', 'Photosynthetic Reaction Center Complex Proteins', 'Rhodobacter capsulatus', 'Spectrophotometry, Atomic', 'Structure-Activity Relationship'] | 8,952,494 | [['D12.125.067.500', 'D12.125.119.170', 'D12.125.427.040'], ['G01.374.661', 'G02.111.490'], ['D05.500.562.488.490', 'D08.811.600.710.490', 'D12.776.543.930.500.490', 'D12.776.765.199.750.750.490'], ['E05.393.420.601.575'], ['D05.500.562.488', 'D08.811.600.710', 'D12.776.543.930.500', 'D12.776.765.199.750.750'], ['B03.4... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Simple method to control a cerebrospinal fluid gusher during cochlear implant surgery. | OBJECTIVE: : Perilymph/cerebrospinal fluid gushers are reported at the time of cochleostomy during the performance of cochlear implant surgery. Anatomic conditions are discussed. Surgical methods of control with tissue seals have varied results. A simple technique using bone-waxed silk suture is described.PATIENTS: : T... | ['Adult', 'Cerebrospinal Fluid Otorrhea', 'Child', 'Child, Preschool', 'Cochlea', 'Cochlear Implantation', 'Female', 'Hearing Loss, Sensorineural', 'Humans', 'Intraoperative Complications', 'Male', 'Otologic Surgical Procedures', 'Sutures', 'Tomography, X-Ray Computed', 'Treatment Outcome'] | 15,241,226 | [['M01.060.116'], ['C10.597.114.500', 'C10.900.300.109.500', 'C23.888.592.114.249', 'C26.915.300.225.500'], ['M01.060.406'], ['M01.060.406.448'], ['A09.246.300.246'], ['E04.580.450.220', 'E04.650.220'], ['C09.218.458.341.887', 'C10.597.751.418.341.887', 'C23.888.592.763.393.341.887'], ['B01.050.150.900.649.313.988.400.... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Species differences in the hepatic microsomal oxidation of nalidixic acid. | The kinetics of the conversion of nalidixic acid to the 7-hydroxymethyl derivative (M-HNA) by isolated liver microsomes of several common laboratory animal species was studied under optimal conditions. The order of activity was (from greatest activity to least): monkey greater than rabbit greater than mouse greater tha... | ['Animals', 'Biotransformation', 'Cats', 'Dogs', 'Haplorhini', 'In Vitro Techniques', 'Kinetics', 'Macaca mulatta', 'Mice', 'Microsomes, Liver', 'Nalidixic Acid', 'Oxidation-Reduction', 'Rabbits', 'Rats', 'Species Specificity'] | 413,504 | [['B01.050'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['B01.050.150.900.649.313.750.250.216.200'], ['B01.050.150.900.649.313.988.400'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['B01.050.150.900.649.313.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Epsilon aminocaproic acid (EACA) myopathy. | Two female patients developed a severe, painful proximal myopathy after taking 18--30 g of epsilon-aminocaproic acid daily for 5 weeks. Marked elevations of serum aminotransferases, creatine kinase and aldolase levels were found and the first patient had electromyographic and muscle biopsy changes of an acute monophasi... | ['Aged', 'Aminocaproates', 'Aminocaproic Acid', 'Female', 'Humans', 'Middle Aged', 'Muscles', 'Muscular Diseases'] | 471,867 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The current role of laparoscopic surgery in the treatment of benign gastroduodenal diseases. | BACKGROUND/AIMS: The impressive breakthrough in laparoscopic surgery has urged several authors to adopt such an approach in the treatment of both benign and malignant gastric diseases, even though laparoscopic gastric resection has not yet met with widespread enthusiasm. The current work is aimed at illustrating the fe... | ['Adult', 'Aged', 'Anastomosis, Roux-en-Y', 'Bile Reflux', 'Duodenal Ulcer', 'Feasibility Studies', 'Female', 'Gastrectomy', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Pyloric Stenosis', 'Stomach Ulcer', 'Treatment Outcome'] | 10,430,287 | [['M01.060.116'], ['M01.060.116.100'], ['E04.035.070', 'E04.210.070'], ['C06.130.140', 'C06.405.748.240.140'], ['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E04.210.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Development of aqueous dispersions of Coenzyme Q10 | Coenzyme Q10 (CoQ10) is a poorly-water soluble compound that is being investigated for the treatment of carcinomas. The aim of this study was to investigate the feasibility of preparing phospholipid-stabilized dispersions of the anticancer agent for continuous pulmonary delivery using a vibrating-mesh nebulizer. We det... | ['Administration, Inhalation', 'Aerosols', 'Drug Compounding', 'Nebulizers and Vaporizers', 'Particle Size', 'Phospholipids', 'Rheology', 'Surface Tension', 'Ubiquinone'] | 27,732,894 | [['E02.319.267.050'], ['D20.280.055', 'D26.255.165.055'], ['E05.916.270'], ['E07.605'], ['G02.712'], ['D10.570.755'], ['E05.830', 'H01.671.808'], ['G02.860.816'], ['D02.806.250.900', 'D08.211.935']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
New cofactors and inhibitors for a DNA-cleaving DNAzyme: superoxide anion and hydrogen peroxide mediated an oxidative cleavage process. | Herein, we investigated the effects of new cofactors and inhibitors on an oxidative cleavage of DNA catalysis, known as a pistol-like DNAzyme (PLDz), to discuss its catalytic mechanism. PLDz performed its catalytic activity in the presence of ascorbic acid (AA), in which Cu2+ promoted, whereas Fe2+ significantly inhibi... | ['DNA Cleavage', 'DNA, Catalytic', 'Hydrogen Peroxide', 'Hydroxyl Radical', 'Hypoxanthine', 'Oxidation-Reduction', 'Pyrogallol', 'Riboflavin', 'Superoxides', 'Xanthine'] | 28,336,968 | [['G02.111.210', 'G05.193'], ['D08.811.165', 'D08.811.913.696.445.735.265', 'D13.444.308.243'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['D01.045.250.357', 'D01.248.497.158.459.300', 'D01.339.431.249'], ['D03.633.100.759.758.399.475'], ['G02.700', 'G03.295.531']... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differentiation of recurrent tumor and posttreatment changes in head and neck squamous cell carcinoma: application of high b-value diffusion-weighted imaging. | BACKGROUND AND PURPOSE: High b-value DWI has been expected to have an additional diagnostic role and demonstrated some promising results in head and neck cancer. The aim of this study was to evaluate the diagnostic performance of DWI at a high b-value (b=2000 s/mm(2)) compared with a standard b-value (b=1000 s/mm(2)) a... | ['Adult', 'Aged', 'Algorithms', 'Carcinoma, Squamous Cell', 'Diagnosis, Differential', 'Diffusion Magnetic Resonance Imaging', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Reproducibility of Results',... | 23,811,978 | [['M01.060.116'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E01.171'], ['E01.370.350.825.500.150'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.1... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Clinical utility of an immunoradiometric assay for parathyroid hormone (1-84) in primary hyperparathyroidism. | The reliable diagnosis of primary hyperparathyroidism depends on the measurement of PTH. The PTH assays in widespread use measure not only the hormone but also hormone fragments, thus limiting the clinical utility of the assays. A new immunoradiometric assay (IRMA) using an antigenic determinant at the extreme amino-te... | ['Adenoma', 'Epitopes', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Hyperparathyroidism', 'Immunoradiometric Assay', 'Male', 'Middle Aged', 'Parathyroid Glands', 'Parathyroid Hormone', 'Parathyroid Neoplasms'] | 14,557,447 | [['C04.557.470.035'], ['D23.050.550'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.642.355'], ['E05.478.566.639.405', 'E05.601.470.639.405'], ['M01.060.116.630'], ['A06.300.560'], ['D06.472.699.590', 'D12.644.548.587'], ['C04.588.322.525', 'C04.588.443.680', 'C19.344.525', 'C1... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Growth and sporulation of Bacillus subtilis mutants blocked in the pyruvate dehydrogenase complex. | Two "ACE" mutants of Bacillus subtilis which require acetate for growth on glucose minimal medium have been isolated. They do not grow with acetoin, 2,3-butanediol, fatty acids, isoleucine, lipoic acid, malic acid, pyruvic acid, succinic acid, thiamine, or valine, but respond somewhat to glutamate or citrate. The mutan... | ['Acetates', 'Bacillus subtilis', 'Carbon Isotopes', 'Citrates', 'Citric Acid Cycle', 'Culture Media', 'Glucose', 'Glutamates', 'Malates', 'Mutation', 'Oxidoreductases', 'Pyruvates', 'Spores', 'Uracil'] | 4,984,174 | [['D02.241.081.018', 'D10.251.400.045'], ['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D01.268.150.075', 'D01.496.123'], ['D02.241.081.901.434'], ['G02.111.165', 'G03.295.342', 'G03.493.170'], ['D27.720.470.305', 'E... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibitory effect of Elephantopus mollis H.B. and K. extract on melanogenesis in B16 murine melanoma cells by downregulating microphthalmia-associated transcription factor expression. | In this study, the inhibitory effect of Elephantopus mollis H.B. and K. extract on melanogenesis in B16 murine melanoma cells was examined and possible mechanisms were elucidated. The melanin content in B16 cells decreased when they were treated with E. mollis extract. Inhibition was accompanied by reduced expression o... | ['Down-Regulation', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Melanins', 'Melanoma', 'Melanoma, Experimental', 'Membrane Glycoproteins', 'Microphthalmia-Associated Transcription Factor', 'Monophenol Monooxygenase', 'Oxidoreductases', 'Plant Extracts', 'Plants, Medicinal', 'Receptor, Melanocortin, Type 1', 'a... | 20,834,163 | [['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.072.050.875.379', 'D23.767.620'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['C04.557.465.625.650.510.525', 'C04.557.580.625.650.510.525', 'C04.557.665.510.525... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phytoavailability and fractionation of copper, manganese, and zinc in soil following application of two composts to four crops. | Two experiments were conducted to evaluate the effect of compost addition to soil on fractionation and bioavailability of Cu, Mn, and Zn to four crops. Soils growing Swiss chard (Beta vulgaris var. cicla L.) and basil (Ocimum basilicum L.) were amended (by volume) with 0, 20, 40, and 60% Source-Separated Municipal Soli... | ['Anethum graveolens', 'Beta vulgaris', 'Biological Availability', 'Copper', 'Linear Models', 'Manganese', 'Manure', 'Mentha piperita', 'Metals, Heavy', 'Ocimum basilicum', 'Soil Pollutants', 'Vegetables', 'Zinc'] | 15,234,085 | [['B01.650.940.800.575.912.250.075.077'], ['B01.650.940.800.575.912.250.200.399'], ['G03.787.151', 'G07.690.725.129'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Expression profile analysis of the polygalacturonase-inhibiting protein genes in rice and their responses to phytohormones and fungal infection. | UNLABELLED: Polygalacturonase-inhibiting proteins (PGIPs) are typically leucine-rich repeat (LRR) proteins that can inhibit the activity of fungal polygalacturonases (PGs). In this study, two new Ospgip genes, named Ospgip6 and Ospgip7 with consensus sequence of ten imperfect LRR motif located on rice chromosomes 8 and... | ['Amino Acid Sequence', 'Computational Biology', 'Gene Expression Profiling', 'Gene Expression Regulation, Plant', 'Molecular Sequence Data', 'Oligonucleotide Array Sequence Analysis', 'Oryza', 'Phylogeny', 'Plant Growth Regulators', 'Plant Proteins', 'Promoter Regions, Genetic', 'Rhizoctonia', 'Transcriptome'] | 22,362,377 | [['G02.111.570.060', 'L01.453.245.667.060'], ['H01.158.273.180', 'L01.313.124'], ['E05.393.332'], ['G05.308.375'], ['L01.453.245.667'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['B01.650.940.800.575.912.250.822.616'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D27.505.696.377.760'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Complete deficiency of adenine phosphoribosyl transferase: report of a new family. | We report a case of 2,8-dihydroxyadenine urinary lithiasis with complete deficiency of adenine phosphoribosyl transferase. Adenine phosphoribosyl transferase activities in the erythrocytes, lymphocytes and granulocytes of the patient's family also were determined. The propositus and her younger brother were homozygotes... | ['Adenine', 'Adenine Phosphoribosyltransferase', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Pentosyltransferases', 'Urinary Calculi'] | 6,887,386 | [['D03.633.100.759.138'], ['D08.811.913.400.725.100'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.400.725'], ['C12.777.967.500', 'C13.351.968.967.500', 'C23.300.175.850']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The Berne-Munich Lifestyle Panel. Background and baseline results from a longitudinal health lifestyle survey. | The Berne-Munich Lifestyle Panel (BMLP) studies health relevant lifestyles among some 2000 adults in Switzerland and Germany. This paper introduces the theoretical background and empirical concept of the BMLP. Sociological theory provided the guidelines for the development of an empirical model that measures structures... | ['Adult', 'Aged', 'Cross-Cultural Comparison', 'Female', 'Germany', 'Health Behavior', 'Health Status', 'Health Surveys', 'Humans', 'Life Style', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Socioeconomic Factors', 'Switzerland', 'Urban Population'] | 10,436,489 | [['M01.060.116'], ['M01.060.116.100'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['Z01.542.315'], ['F01.145.488'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458'],... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Occipital artery-to-posterior inferior cerebellar artery bypass for treatment of bilateral vertebral artery occlusion: the role of quantitative magnetic resonance angiography noninvasive optimal vessel analysis: technical case report. | OBJECTIVE: Patients with partial or complete bilateral vertebral artery occlusion often present with signs and symptoms of transient ischemic attacks or infarction. Advances in phase contrast magnetic resonance imaging have led to noninvasive assessment of volumetric blood flow rates and direction that help in the work... | ['Adult', 'Cerebral Arteries', 'Cerebral Revascularization', 'Humans', 'Magnetic Resonance Angiography', 'Male', 'Vertebrobasilar Insufficiency'] | 19,349,810 | [['M01.060.116'], ['A07.015.114.228'], ['E04.100.814.868.625', 'E04.494.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500.500', 'E01.370.370.050.500'], ['C10.228.140.300.150.956', 'C14.907.253.092.956']] | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Natural peppermint-flavored cheese. | BACKGROUND: The essential oils of edible and medicinal plants, herbs and spices are natural biologically ac- tive agents. Peppermint has a special position in Egyptian culture and is used as fresh or dried leaves. One of the main aims of the food industry is to manufacture products with good sensory acceptance. The pre... | ['Animals', 'Antioxidants', 'Buffaloes', 'Cheese', 'Drosophila Proteins', 'Flavoring Agents', 'Humans', 'MAP Kinase Kinase Kinases', 'Mentha piperita', 'Oils, Volatile', 'Plant Extracts', 'Plant Leaves'] | 30,927,754 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['B01.050.150.900.649.313.500.380.135'], ['G07.203.200.500.444', 'G07.203.300.350.300.444', 'J02.350.500.444', 'J02.500.350.300.444'], ['D12.776.093.500.462'], ['D26.650.294', 'D27.720.372.300.353', 'D27.720.744.294', 'G07.203.300.514.500.400'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
One-Stage versus Two-Stage Arteriovenous Loop Reconstructions: An Experience on 103 Cases from a Single Center. | BACKGROUND: The optimal time for flap anastomosis to an arteriovenous loop remains controversial. Whether perforator flaps and axially vascularized muscle or fasciocutaneous flaps lead to comparable outcomes in conjunction with arteriovenous loops has not been investigated.METHODS: Medical records from 103 patients und... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anastomosis, Surgical', 'Child', 'Female', 'Free Tissue Flaps', 'Graft Occlusion, Vascular', 'Graft Rejection', 'Humans', 'Male', 'Middle Aged', 'Reconstructive Surgical Procedures', 'Retrospective Studies', 'Thrombosis', 'Time Factors', 'Treatment Outcome', 'Vascul... | 30,624,338 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.035'], ['M01.060.406'], ['A10.850.710.500', 'E07.862.710.500'], ['C23.550.767.400'], ['G12.875.545.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.680'], ['E05.318.372.500.500.500', 'E05.318.372.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
HMG-CoA reductase inhibitors (statins) and acute kidney injury: A secondary analysis of renal study outcomes. | BACKGROUND: Mortality in intensive care unit (ICU) patients with acute kidney injury (AKI) remains high. Previous studies have explored the role of HMG-CoA reductase inhibitors (statins) with variable findings.METHODS: The Randomized Evaluation of Normal versus Augmented Level Replacement Therapy (RENAL) Study recruite... | ['Acute Kidney Injury', 'Aged', 'Aged, 80 and over', 'Cause of Death', 'Critical Illness', 'Female', 'Humans', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Intensive Care Units', 'Male', 'Middle Aged', 'Randomized Controlled Trials as Topic', 'Renal Dialysis', 'Risk Assessment', 'Risk Factors', 'Sepsis', 'Time Fa... | 31,058,387 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['C23.550.291.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.186.071.202.370', 'D27.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Generation of toxic degradation products by sonication of Pluronic® dispersants: implications for nanotoxicity testing. | Poloxamers (known by the trade name Pluronic®) are triblock copolymer surfactants that contain two polyethylene glycol blocks and one polypropylene glycol block of various sizes. Poloxamers are widely used as nanoparticle dispersants for nanotoxicity studies wherein nanoparticles are sonicated with a dispersant to prep... | ['Animals', 'Cell Culture Techniques', 'Cell Line', 'Cell Survival', 'Glutathione', 'Kidney', 'Microscopy, Phase-Contrast', 'Nanotubes, Carbon', 'Poloxamer', 'Rats', 'Reactive Oxygen Species', 'Serum Albumin, Bovine', 'Sonication', 'Suspensions', 'Toxicity Tests'] | 23,030,523 | [['B01.050'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251.210'], ['G04.346'], ['D12.644.456.448'], ['A05.810.453'], ['E01.370.350.515.513.569', 'E05.490.630.569', 'E05.595.513.569'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['D02.033.455.250.700.682', 'D05.750.741.667'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Evidence for an increase in adrenergic nerve function in blood vessels from experimental hypertensive rabbits. | The possibility of changes in the adrenergic innervation of blood vessels in experimental hypertension was investigated by measuring arterial norepinephrine content, neuronal uptake of norepinephrine, and the neurogenic contractile response in rabbits made hypertensive by partial constriction of the abdominal aorta pro... | ['Animals', 'Aorta, Abdominal', 'Blood Pressure', 'Blood Vessels', 'Constriction', 'Disease Models, Animal', 'Hypertension', 'Nerve Endings', 'Neurons', 'Neurotransmitter Agents', 'Norepinephrine', 'Rabbits', 'Sympathetic Nervous System', 'Vasomotor System'] | 241,508 | [['B01.050'], ['A07.015.114.056.205'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A07.015'], ['E05.225'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C14.907.489'], ['A08.800.550'], ['A08.675', 'A11.671'], ['D27.505.519.625', 'D27.505.696.577'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', ... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Perioperative management of a patient with myasthenia gravis using dexmedetomidine]. | We performed two successive operations in a 39-year-old pregnant woman with myasthenia gravis (MG) with perioperative administration of dexmedetomidine. The first was an emergency cesarean section at 28 weeks' gestation. The patient was administered vecuronium, a muscle relaxant during the operation. She was sedated wi... | ['Adult', 'Cesarean Section', 'Dexmedetomidine', 'Female', 'Humans', 'Myasthenia Gravis', 'Neuromuscular Agents', 'Perioperative Care', 'Pregnancy', 'Thymectomy'] | 19,928,518 | [['M01.060.116'], ['E04.520.252.500'], ['D03.383.129.308.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.614.550.500', 'C04.730.856.490', 'C10.114.656', 'C10.574.781.588', 'C10.668.758.725', 'C20.111.258.500'], ['D27.505.696.663.700'], ['E02.760.731', 'E04.604', 'N02.421.585.722'], ['G08.686.784.769']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transvaginal sonographic diagnosis of live monochorionic twin ectopic pregnancy. | Ectopic pregnancy is a leading cause of pregnancy-related deaths; its incidence has progressively increased in recent years. Spontaneous twin ectopic pregnancy, however, is extremely rare. Among more than 100 reported cases of twin tubal pregnancies, only 5 cases in which fetal cardiac motion has been visualized in bot... | ['Adult', 'Female', 'Fetal Heart', 'Humans', 'Pregnancy', 'Pregnancy, Ectopic', 'Pregnancy, Multiple', 'Twins', 'Ultrasonography'] | 11,807,857 | [['M01.060.116'], ['A07.541.278', 'A16.378.303'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['C13.703.733'], ['G08.686.784.769.545'], ['M01.438.873'], ['E01.370.350.850']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Enzyme kinetics of a highly purified mitochondrial creatine kinase in comparison with cytosolic forms. | Mitochondrial creatine kinase (CK) purified from canine myocardium showed a single protein band on SDS-PAGE and was free of MMCK. Its amino acid composition was different than MMCK or BBCK and did not react to antiserum to MMCK or BBCK. Using purified mitochondrial, MM and BBCK, the velocity of reaction (V) was estimat... | ['Amino Acids', 'Animals', 'Creatine Kinase', 'Cytosol', 'Dogs', 'Immunochemistry', 'In Vitro Techniques', 'Isoenzymes', 'Kinetics', 'Mitochondria, Heart', 'Molecular Weight', 'Myocardium'] | 4,047,027 | [['D12.125'], ['B01.050'], ['D08.811.913.696.640.150'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['B01.050.150.900.649.313.750.250.216.200'], ['H01.158.201.486', 'H01.181.122.605', 'H02.403.044.500'], ['E05.481'], ['D08.811.348', 'D12.776.800.300'], ['G01.374.661', 'G02.111.490'], ['A11.28... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. | BACKGROUND: Establishment and maintenance of a functional central nervous system (CNS) requires a highly orchestrated process of neural progenitor cell proliferation, cell cycle exit, and differentiation. An evolutionary conserved program consisting of Notch signalling mediated by basic Helix-Loop-Helix (bHLH) transcri... | ['Animals', 'Basic Helix-Loop-Helix Transcription Factors', 'Central Nervous System', 'Embryonic Development', 'Gene Expression', 'Gene Expression Regulation', 'In Situ Hybridization', 'Mice', 'Multigene Family', 'Neurogenesis', 'Neurons', 'Proto-Oncogenes', 'Reverse Transcriptase Polymerase Chain Reaction', 'Transcrip... | 19,050,759 | [['B01.050'], ['D12.776.260.103', 'D12.776.930.125'], ['A08.186'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['G05.297'], ['G05.308'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['B01.050.150.900.649.313.992.635.505.500'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Filippi syndrome: two cases with ectodermal features, expanding the phenotype. | We report two unrelated children with Filippi syndrome. Both show typical facial dysmorphism, syndactyly of fingers and toes, growth retardation, postnatal microcephaly and developmental delay, particularly involving speech. In addition both children have unusual teeth and hair. We review the literature and propose tha... | ['Adolescent', 'Child, Preschool', 'Developmental Disabilities', 'Facies', 'Hair', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Microcephaly', 'Syndactyly', 'Syndrome', 'Tooth Abnormalities'] | 15,365,457 | [['M01.060.057'], ['M01.060.406.448'], ['F03.625.421'], ['C23.550.291.812', 'E01.370.600.230'], ['A17.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C05.660.207.620', 'C10.500.507.400.500', 'C16.131.621.207.620', 'C16.131.666.507.400.500'], ['C05.116.099.370.894.819', 'C... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Alpha-adrenoceptor properties in rat strains sensitive or resistant to salt-induced hypertension. | Cerebral and renal alpha 2-adrenoceptors are implicated in the control of sympathetic activity and of sodium reabsorption respectively. In addition, sodium ions play an important role in the regulation of either alpha 2-adrenoceptor densities and affinities for adrenergic agonists. In the present study, alpha-adrenocep... | ['Animals', 'Cerebral Cortex', 'Hypertension', 'Kidney Cortex', 'Kinetics', 'Male', 'Norepinephrine', 'Prazosin', 'Rats', 'Rats, Inbred Strains', 'Receptors, Adrenergic, alpha', 'Sodium Chloride', 'Species Specificity', 'Yohimbine'] | 2,558,064 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['C14.907.489'], ['A05.810.453.324'], ['G01.374.661', 'G02.111.490'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', 'D02.092.311.830', 'D02.455.426.559.389.657.166.175.830'], ['D03.633.100.786.750'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.05... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation. | Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because the MDM2 targetome extends beyond p53, MDM2 inhibition may also cause unwanted activation of oncogenic pathways. Acco... | ['Animals', 'Breast Neoplasms', 'Drug Resistance, Neoplasm', 'Estrogen Receptor alpha', 'Estrogens', 'Female', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'MCF-7 Cells', 'Mice', 'Phosphorylation', 'Protein-Serine-Threonine Kinases', 'Proto-Oncogene Proteins c-akt', 'Proto-Oncogene Proteins c-mdm2', 'Sign... | 24,488,098 | [['B01.050'], ['C04.588.180', 'C17.800.090.500'], ['G07.690.773.984.395'], ['D12.776.826.750.350.174'], ['D27.505.696.399.472.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['A11.251.210.190.630'], ['B01.050.150.900.649.313.992.635.505.500'], ['G02.111.665', 'G02.607.780', 'G03.... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Smoked and smokeless tobacco use among pulmonary tuberculosis patients under RNTCP in urban Puducherry, India. | BACKGROUND: Smoking is associated with unfavourable treatment outcomes like failures and defaults among the TB patients.OBJECTIVES: To study the prevalence and pattern of tobacco use among the pulmonary tuberculosis (PTB) patients in urban Pondicherry and study the association of various socio-demographic variables wit... | ['Cross-Sectional Studies', 'Female', 'Humans', 'India', 'Male', 'Prevalence', 'Smoke', 'Smoking', 'Tobacco Use Cessation', 'Tobacco, Smokeless', 'Tuberculosis, Pulmonary'] | 27,865,237 | [['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['D20.633.937'], ['F01.145.805'], ['F01.145.488.750'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Early results of laparoscopic resection of the stomach. | BACKGROUND/AIMS: In this study we present our experiences and results in patients who underwent laparoscopic resection of the stomach.METHODOLOGY: Our study presents five patients that underwent laparoscopy in the period 2006-2008, at the surgical department of the General hospital Djordje Joanovic in Zrenjanin, Serbia... | ['Adult', 'Aged', 'Female', 'Gastrectomy', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Stomach Neoplasms'] | 22,580,665 | [['M01.060.116'], ['M01.060.116.100'], ['E04.210.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Entrance of cholera enterotoxin subunits into thymus cells. | Analysis of the staining of cholera enterotoxin on the surface of cells with specific antibodies against each subunit of cholera enterotoxin, using a fluorescence-activated cell sorter and electron microscopy, showed that not only subunit A but also subunit B penetrates the cell membrane. The detection of subunits insi... | ['Animals', 'Cholera', 'Enterotoxins', 'Histocytochemistry', 'Mice', 'Microscopy, Electron', 'Microscopy, Fluorescence', 'Saponins', 'Thymus Gland'] | 6,501,862 | [['B01.050'], ['C01.150.252.400.959.347'], ['D23.946.330'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.350.515.402', 'E05.595.402'], ['E01.370.350.515.458', 'E05... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Direct contrast-enhanced 3D MR venography evaluation of upper extremity deep venous system. | PURPOSE: To investigate the diagnostic value of direct contrast-enhanced three dimensional magnetic resonance (3D MR) venography in mapping the deep venous system of the upper extremities and to plan potential interventional procedures.MATERIALS AND METHODS: Nineteen cases with the diagnoses of end-stage renal disease ... | ['Adult', 'Aged', 'Contrast Media', 'Female', 'Gadolinium DTPA', 'Humans', 'Injections, Intravenous', 'Kidney Failure, Chronic', 'Magnetic Resonance Angiography', 'Male', 'Middle Aged', 'Phlebography', 'Predictive Value of Tests', 'Sensitivity and Specificity', 'Thromboembolism', 'Upper Extremity', 'Veins'] | 16,752,353 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.259.500', 'D27.720.259'], ['D02.092.782.590.401', 'D02.241.081.018.639.400', 'D02.257.141'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['E01.370.350.825.500... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Inefficient degradation of oxidized regions of protein molecules. | We have previously shown that the intracellular half-life of endocytosed oxidized albumin is much longer than that of native albumin. We now report that the regions of oxidized albumin which contain oxidation products (carbonyls and fluorophores), are less readily released as small degradation products by cell-free pro... | ['Endopeptidases', 'Half-Life', 'Hydrolysis', 'Macrophages', 'Oxidation-Reduction', 'Peptide Fragments', 'Phenylhydrazines', 'Serum Albumin, Bovine', 'Spectrometry, Fluorescence', 'Trypsin'] | 8,370,549 | [['D08.811.277.656.300'], ['G01.910.405'], ['G02.380'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['G02.700', 'G03.295.531'], ['D12.644.541'], ['D02.442.726'], ['D12.776.034.841.540', 'D12.776.124.727.875'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['D08.811.277.656.300... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Normal mode analysis as a prerequisite for drug design: application to matrix metalloproteinases inhibitors. | We demonstrate the utility of normal mode analysis in correctly predicting the binding modes of inhibitors in the active sites of matrix metalloproteinases (MMPs). We show the accuracy in predicting the positions of MMP-3 inhibitors is strongly dependent on which structure is used as the target, especially when it has ... | ['Drug Design', 'Matrix Metalloproteinase 3', 'Models, Chemical', 'Models, Molecular', 'Protease Inhibitors', 'Protein Structure, Tertiary', 'Software', 'Structure-Activity Relationship'] | 16,962,102 | [['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D08.811.277.656.300.480.525.700.200', 'D08.811.277.656.675.374.525.700.200', 'D12.644.276.848.200', 'D12.776.467.836.200'], ['E05.599.495'], ['E05.599.595'], ['D27.505.519.389.745'], ['G02.111.570.820.709.610'], ['L01.224.900'], ['G02.111.830', 'G07.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Detection of cells of megakaryocyte lineage in haematological malignancies by immuno-alkaline phosphatase labelling cell smears with a panel of monoclonal antibodies. | Immuno-alkaline phosphatase staining (by the APAAP technique) has been used to identify promegakaryoblasts in cell smears from 10 cases of leukaemia (three acute leukaemia, seven blast transformations). In all cases promegakaryoblasts were labelled by at least two anti-platelet glycoprotein (gp) antibodies, the highest... | ['Acute Disease', 'Alkaline Phosphatase', 'Antibodies, Monoclonal', 'Blast Crisis', 'Bone Marrow', 'Humans', 'Immunoenzyme Techniques', 'Leukemia', 'Megakaryocytes'] | 3,545,280 | [['C23.550.291.125'], ['D08.811.277.352.650.035'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['C04.557.337.539.250.100', 'C04.697.098.500.110', 'C15.378.190.636.370.100', 'C23.550.727.098.500.110'], ['A15.382.216'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The presence of Mycoplasma hominis in isolates of Trichomonas vaginalis impacts significantly on DNA fingerprinting results. | The genetic characterization of Trichomonas vaginalis (Protista: Trichomonadidae), the causative agent of trichomoniasis in humans, is central to understanding the epidemiology, treatment, drug resistance, and virulence as well as the diagnosis and control of this parasite. Various molecular approaches, including DNA f... | ['Animals', 'DNA Fingerprinting', 'DNA, Protozoan', 'Diagnostic Errors', 'Mycoplasma hominis', 'Polymerase Chain Reaction', 'Random Amplified Polymorphic DNA Technique', 'Symbiosis', 'Trichomonas vaginalis'] | 18,058,131 | [['B01.050'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['D13.444.308.442'], ['E01.354', 'N02.421.450.280'], ['B03.440.860.580.553.553.400'], ['E05.393.620.500'], ['E05.393.620.500.687', 'E05.601.700'], ['G06.550.800', 'G16.840'], ['B01.630.800.808.717']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Crohn's disease - genetic factors and progress of the disease. | BACKGROUND AND OBJECTIVES: Crohn's disease is a multifactorial inflammatory disease affecting mainly the gastrointestinal tract. The genetic factors that are involved in the disease include mainly three mutations of the gene NOD2/CARD15 (R702W, G908R, 3020insC). The aim of this study was to determine the relationship b... | ['Adult', 'Aged', 'Crohn Disease', 'Female', 'Genetic Predisposition to Disease', 'Heterozygote', 'Homozygote', 'Humans', 'Male', 'Middle Aged', 'Mutation', 'Nod2 Signaling Adaptor Protein', 'Phenotype', 'Prospective Studies', 'Reoperation', 'Young Adult'] | 29,358,789 | [['M01.060.116'], ['M01.060.116.100'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380.383'], ['G05.380.554'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G05.365.590'], ['D12.644.360.024.131.500', 'D12.644.360.024.313.500', 'D12.644.360.075.... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Novel natriuretic peptides from the venom of the inland taipan (Oxyuranus microlepidotus): isolation, chemical and biological characterisation. | Three natriuretic-like peptides (TNP-a, TNP-b, and TNP-c) were isolated from the venom of Oxyuranus microlepidotus (inland taipan) and were also present in the venoms of Oxyuranus scutellatus canni (New Guinea taipan) and Oxyuranus scutellatus scutellatus (coastal taipan). They were isolated by HPLC, characterised by m... | ['Amino Acid Sequence', 'Animals', 'Aorta', 'Chromatography, Liquid', 'Elapid Venoms', 'Elapidae', 'Endothelial Cells', 'Humans', 'Male', 'Mass Spectrometry', 'Molecular Sequence Data', 'Natriuretic Peptides', 'Rats', 'Sequence Alignment'] | 15,652,496 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A07.015.114.056'], ['E05.196.181.400'], ['D20.888.850.325', 'D23.946.833.850.325'], ['B01.050.150.900.833.672.125.875'], ['A11.436.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.566'], ['L01.453.245.667'], ['D06.472.699.584', 'D12.644.548.58... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Comparison of synchronous dual wavelength diode laser versus conventional endo-knives for esophageal endoscopic submucosal dissection: an animal study. | BACKGROUND: Endoscopic submucosal dissection (ESD) is widely used for en bloc resection in early gastrointestinal cancer. However, it is technically complex with long procedure time and high adverse event rates with using conventional knives. The aim of this animal study was to verify the feasibility of ESD using a nov... | ['Animals', 'Blood Loss, Surgical', 'Endoscopic Mucosal Resection', 'Esophagus', 'Hemostasis, Surgical', 'Humans', 'Lasers, Semiconductor', 'Models, Anatomic', 'Surgical Instruments', 'Swine', 'Treatment Outcome'] | 30,116,950 | [['B01.050'], ['C23.550.414.300', 'C23.550.505.300'], ['E01.370.372.250.250.250', 'E01.370.388.250.250.250.230', 'E04.210.240.250.230', 'E04.502.250.250.250.230'], ['A03.556.875.500'], ['E02.520.490', 'E04.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.632.490.480', 'E07.710.520.480'], ['J01.897.280.500.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Analysis of serum copper and zinc concentrations in cancer patients. | Several studies have shown that plasma copper concentrations are increased in various carcinomas. Zinc acts as a cellular growth protector, including growth of neoplastic cells, and its deficiency was demonstrated to be involved in several stages of malignant transformation. However, the usefulness of the serum zinc an... | ['Adult', 'Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Case-Control Studies', 'Copper', 'Female', 'Gastrointestinal Neoplasms', 'Genital Neoplasms, Female', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Metastasis', 'Neoplasms', 'Prognosis', 'Zinc'] | 11,697,759 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['C04.588.274.476', 'C06.301.371', 'C06.405.249'], ['C04.588.945.418', 'C13.351.93... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results. | OBJECTIVES: Non-syndromic orofacial clefts, i.e. cleft lip (CL) and cleft palate (CP), are among the most common birth defects. The goal of this study was to identify genomic regions and genes for CL with or without CP (CL/P).METHODS: We performed linkage analyses of a 10 cM genome scan in 820 multiplex CL/P families (... | ['Chromosome Mapping', 'Chromosomes, Human', 'Cleft Lip', 'Cleft Palate', 'Genetic Linkage', 'Genetic Predisposition to Disease', 'Genome, Human', 'Genome-Wide Association Study', 'Humans', 'Phenotype', 'Polymorphism, Single Nucleotide'] | 19,521,098 | [['E05.393.183'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['C07.465.409.225', 'C07.465.525.164', 'C07.650.525.164', 'C16.131.850.525.164'], ['C05.500.460.185', 'C05.660.207.540.460.185', 'C07.320.440.185', 'C07.465.525.185', 'C07.650.500.460.185', 'C07.650.525.185', 'C16.131.621.207.540.460.185', 'C16.131.850.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
PKCI-W forms a heterodimer with PKCI-Z and inhibits the biological activities of PKCI-Z in vitro, supporting the predicted role of PKCI-W in sex determination in birds. | The two chicken genes, PKCI-W on the W chromosome and PKCI-Z on the Z chromosome, belong to the gene family encoding the Hint (histidine triad nucleotide-binding protein)-branch proteins in the widely conserved HIT (histidine triad)-family. It has been speculated that PKCI-W is involved in the sex determination of bird... | ['Amino Acid Sequence', 'Animals', 'Birds', 'Chromosome Mapping', 'Dimerization', 'Hydrolases', 'Molecular Sequence Data', 'Recombinant Fusion Proteins'] | 16,428,323 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.248'], ['E05.393.183'], ['G02.206', 'G03.230'], ['D08.811.277'], ['L01.453.245.667'], ['D12.776.828.300']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Medicaid Hearing Aid Coverage For Older Adult Beneficiaries: A State-By-State Comparison. | Age-related hearing loss affects nearly thirty million older adults in the United States and is associated with increased risk of several other adverse health outcomes. Although hearing aids are the most common efficacious treatment, Medicaid coverage of the aids is not federally mandated, and cost has been cited as a ... | ['Adult', 'Aged', 'Eligibility Determination', 'Health Services Accessibility', 'Hearing Aids', 'Humans', 'Insurance Coverage', 'Male', 'Medicaid', 'Middle Aged', 'Patient Protection and Affordable Care Act', 'United States'] | 28,784,741 | [['M01.060.116'], ['M01.060.116.100'], ['N04.452.264'], ['N04.590.374.350', 'N05.300.430'], ['E07.305.906.500', 'E07.814.458'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.265'], ['N03.219.521.346.506.564.655', 'N03.706.615.693'], ['M01.060.116.630'], ['N03.219.521.576.343.918', 'N03.706.615.806'... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The increasingly complex fourth hurdle for pharmaceuticals. | There are three known criteria that underlie drug reimbursement decisions: therapeutic value, cost effectiveness and burden of disease. However, evidence from recent reimbursement decisions in several jurisdictions points to residual unexplained variables, one of which may be budget impact. An economic rationale for ca... | ['Cost of Illness', 'Cost-Benefit Analysis', 'Decision Making', 'Humans', 'Insurance, Health, Reimbursement', 'Insurance, Pharmaceutical Services'] | 17,803,332 | [['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['N03.219.151.125'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.343.480', 'N03.219.521.710'], ['N03.219.521.576.343.575']] | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Silicone intubation for lacerated lacrimal canaliculi. | Twenty-two cases of lacerated canaliculi were repaired with the use of silicone tube stents. Of the 18 patients having early repair, 17 (94%) had a good result and one (6%) fair. The four patients with late repair yielded three (75%) with a poor result and one (25%) fair. Primary repair of lacerated canaliculi by this ... | ['Adolescent', 'Adult', 'Catheters, Indwelling', 'Child', 'Child, Preschool', 'Eyelids', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Lacrimal Apparatus', 'Male', 'Middle Aged', 'Nasolacrimal Duct', 'Silicones', 'Suture Techniques', 'Wound Healing'] | 3,906,483 | [['M01.060.057'], ['M01.060.116'], ['E07.132.500'], ['M01.060.406'], ['M01.060.406.448'], ['A01.456.505.420.504', 'A09.371.337'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['A09.371.463', 'A10.336.422'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Silver nanoparticle inhibition of polycyclic aromatic hydrocarbons degradation by Mycobacterium species RJGII-135. | UNLABELLED: Polycyclic aromatic hydrocarbons (PAH) are a common environmental contaminant originating from both anthropogenic and natural sources. Mycobacterium species are highly adapted to utilizing a variety of PAH. Silver nanoparticles (AgNP) are an emerging contaminant that possess bactericidal properties, interfe... | ['Biodegradation, Environmental', 'Environmental Pollutants', 'Metal Nanoparticles', 'Mycobacterium', 'Naphthalenes', 'Polycyclic Aromatic Hydrocarbons', 'Silver'] | 24,286,199 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['D27.888.284'], ['J01.637.512.600.500'], ['B03.510.024.962.500', 'B03.510.460.400.410.552.552'], ['D02.455.426.559.847.638', 'D04.615.638'], ['D02.455.426.559.847', 'D04.615'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812']] | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Computationally designed libraries of fluorescent proteins evaluated by preservation and diversity of function. | To determine which of seven library design algorithms best introduces new protein function without destroying it altogether, seven combinatorial libraries of green fluorescent protein variants were designed and synthesized. Each was evaluated by distributions of emission intensity and color compiled from measurements m... | ['Combinatorial Chemistry Techniques', 'Drug Design', 'Green Fluorescent Proteins', 'Peptide Library', 'Protein Engineering'] | 17,179,210 | [['E05.197.312', 'J01.897.836.249.249'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D12.776.532.265'], ['D12.644.555', 'G02.111.570.060.620', 'G05.360.325.640'], ['E05.393.420.601']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Chiral diols: a new class of additives for direct aldol reaction catalyzed by L-proline. | Nine C2 symmetric diols have been examined as additives in the L-proline-catalyzed direct aldol reaction with significant improvement in enantioselectivity, conversion efficiency, and yield. Loading of 1 mol % of (S)-BINOL leads to the desired products in up to 98% ee and 90% yield. A transition state is proposed. | ['Alcohols', 'Catalysis', 'Proline', 'Stereoisomerism'] | 17,137,384 | [['D02.033'], ['G02.130'], ['D12.125.072.401.623'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Family history in primary open-angle glaucoma. | A family history of glaucoma was found in 50% of patients with primary open-angle glaucoma (POAG) and 43% of patients with ocular hypertension (OH). Positive family history was twice as prevalent in those with OH and either HLA-B7 or B12 antigens than in OH with neither antigen (P less than .01). Although POAG occurred... | ['African Americans', 'Antigens', 'European Continental Ancestry Group', 'Female', 'Follow-Up Studies', 'Glaucoma', 'Histocompatibility', 'Humans', 'Intraocular Pressure', 'Male', 'Missouri', 'Sex Factors'] | 849,183 | [['M01.686.508.100.100', 'M01.686.754.100'], ['D23.050'], ['M01.686.508.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C11.525.381'], ['G12.875.519'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['Z01.107.567.875.510.515'], ['N05.715.350.675', 'N06.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Treatment of imminent premature labour. | In this study, 194 imminent premature deliveries were treated. The pregnancies were in the 28th to 36th week. Uterine contractions were demonstrable in all patients and amniotic membranes were intact. All patients were treated with bedrest. Two betasympathomimetics were used in a double-blind study: Nyldrin hydrochlori... | ['Birth Weight', 'Clinical Trials as Topic', 'Ethanol', 'Female', 'Follow-Up Studies', 'Gestational Age', 'Humans', 'Infant, Newborn', 'Isoxsuprine', 'Nylidrin', 'Obstetric Labor, Premature', 'Placebos', 'Pregnancy'] | 1,094,787 | [['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['D02.033.375'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.35... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Defining the learning curve for team-based laparoscopic pancreaticoduodenectomy. | BACKGROUND: The purpose of this study was to define the learning curves for laparoscopic pancreaticoduodenectomy (LPD) with and without laparoscopic reconstruction, using paired surgical teams consisting of advanced laparoscopic-trained surgeons and advanced oncologic-trained surgeons.METHODS: All patients undergoing P... | ['Aged', 'Anastomosis, Surgical', 'Female', 'Follow-Up Studies', 'Humans', 'Laparoscopy', 'Learning Curve', 'Length of Stay', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Operative Time', 'Pancreatic Neoplasms', 'Pancreaticoduodenectomy', 'Postoperative Complications', 'Practice Guidelines as Topic', 'Prognosis', 'Retro... | 24,923,222 | [['M01.060.116.100'], ['E04.035'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['F02.784.629.529.274'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], ['E01.789.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Microstructure and mechanical behavior of metal injection molded Ti-Nb binary alloys as biomedical material. | The application of titanium (Ti) based biomedical materials which are widely used at present, such as commercially pure titanium (CP-Ti) and Ti-6Al-4V, are limited by the mismatch of Young's modulus between the implant and the bones, the high costs of products, and the difficulty of producing complex shapes of material... | ['Alloys', 'Biocompatible Materials', 'Injections', 'Mechanical Phenomena', 'Niobium', 'Titanium'] | 23,994,942 | [['D01.552.033', 'D25.058', 'J01.637.051.058'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['E02.319.267.530'], ['G01.374'], ['D01.268.556.615', 'D01.268.956.687', 'D01.552.544.615'], ['D01.268.557.800', 'D01.268.956.878', 'D01.552.547.800']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Progress toward measles elimination--region of the Americas, 2002-2003. | In 1994, countries in the Region of the Americas adopted the goal of eliminating endemic measles transmission in the Western hemisphere by 2000. Since 1994, rapid progress has been made. The number of measles cases has declined >99%, from approximately 250,000 in 1990 to 105 confirmed cases reported in six countries in... | ['Americas', 'Humans', 'Immunization Programs', 'Measles', 'Measles Vaccine', 'Vaccination'] | 15,085,074 | [['Z01.107'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.726.608'], ['C01.925.782.580.600.500.500'], ['D20.215.894.899.404'], ['E02.095.465.425.400.530.890', 'E05.478.550.600.890', 'N02.421.726.758.310.890', 'N06.850.780.200.425.900', 'N06.850.780.680.310.890']] | ['Geographicals [Z]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Reducing Hospital Readmissions Among Incarcerated Patients. | In many health care settings, hospital readmissions represent poor quality and increased costs. The California Department of Corrections and Rehabilitation includes reduced readmission rates among key performance indicators for the quality of care provided to inmates. More than 25% of the institutions continue to face ... | ['Adult', 'Algorithms', 'California', 'Female', 'Humans', 'Male', 'Patient Readmission', 'Prisoners', 'Prisons', 'Substance-Related Disorders'] | 29,303,035 | [['M01.060.116'], ['G17.035', 'L01.224.050'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.620', 'N02.421.585.400.620'], ['M01.729'], ['I01.880.604.787', 'J03.220.500'], ['C25.775', 'F03.900']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Di... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
High-resolution MRI vessel wall imaging: spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis. | BACKGROUND AND PURPOSE: High-resolution MR imaging is an emerging tool for evaluating intracranial artery disease. It has an advantage of defining vessel wall characteristics of intracranial vascular diseases. We investigated high-resolution MR imaging arterial wall characteristics of CNS vasculitis and reversible cere... | ['Adult', 'Aged', 'Cerebrovascular Disorders', 'Female', 'Humans', 'Magnetic Resonance Angiography', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Retrospective Studies', 'Tomography, X-Ray Computed', 'Vasculitis, Central Nervous System', 'Vasoconstriction'] | 24,722,305 | [['M01.060.116'], ['M01.060.116.100'], ['C10.228.140.300', 'C14.907.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500.500', 'E01.370.370.050.500'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mutagenesis induced by 5-bromouracil and methyl methane sulfonate: role of DNA polymerase I. | A polA1 mutation in the DNA polymerase I gene of E. coli results in a drastic reduction of the frequency of mutagenesis induced by 5-bromo-2'-deoxyuridine (BUdR). Comparisons of the effect of a polA1 mutation on mutagenesis induced by methyl methane sulfonate (MMS), ultraviolet irradiation (UV) and 2-aminopurine (2-AP)... | ['Bromodeoxyuridine', 'DNA Polymerase I', 'DNA Repair', 'Escherichia coli', 'Methyl Methanesulfonate', 'Mutation'] | 6,372,342 | [['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['D08.811.913.696.445.308.300.225'], ['G02.111.222', 'G05.219'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D02.455.326.146.100.050.500.500', 'D02.886.645.600.055.050.510.500'], ['G05.365.590']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Diagnosis of recurrence of a glomus carotid artery tumor by somatostatin receptor scintigraphy]. | Glomus caroticum tumours belong to the non chromaffine paragangliomas. As the incidence is very poor with 1% in the collective of a vascular-surgery department, the correct diagnosis is preoperatively only found in 10-20% of the cases. The early detection of primary- or recurrence-tumour is important for the surgical p... | ['3-Iodobenzylguanidine', 'Adult', 'Carotid Artery Diseases', 'Catecholamines', 'Cicatrix', 'Diagnosis, Differential', 'Female', 'Glomus Tumor', 'Humans', 'Indium Radioisotopes', 'Iodine Radioisotopes', 'Iodobenzenes', 'Muscle Neoplasms', 'Neoplasm Staging', 'Radionuclide Imaging', 'Receptors, Somatostatin', 'Recurrenc... | 8,746,171 | [['D02.078.370.510', 'D02.455.426.559.389.454.300', 'D02.455.526.581.496.300'], ['M01.060.116'], ['C10.228.140.300.200', 'C14.907.253.123'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['A10.165.450.300', 'C23.550.355.274', 'G16.762.891.249'], ['E01.171'], ['C04.557.645.350'], ['B01.050.150.900.649.313.988.400.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol. | Inositol polyphosphate 4-phosphatase (4-phosphatase) is an enzyme that catalyses the hydrolysis of the 4-position phosphate from phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P2]. In human platelets the formation of this phosphatidylinositol, by the actions of phosphatidylinositol 3-kinase (PI 3-kinase), correlates... | ['Blood Platelets', 'Cytosol', 'Humans', 'Kinetics', 'Macromolecular Substances', 'Phosphatidylinositol 3-Kinases', 'Phosphoric Monoester Hydrolases', 'Thrombin'] | 10,097,090 | [['A11.118.188', 'A15.145.229.188'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D05'], ['D08.811.913.696.620.500'], ['D08.811.277.352.650'], ['D08.811.277.656.300.760.855', 'D08.811.277.656.959.350.855', 'D12.... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of mutations in Pisum sativum L. genes blocking different stages of nodule development on the expression of late symbiotic genes in Rhizobium leguminosarum bv. viciae. | In this report, the expression of late symbiotic genes (fnrN, fixN, and nifA) of Rhizobium leguminosarum bv. viciae was studied in nodules of mutant pea lines blocked at four successive stages of nodule development. Bacterial gene expression was analyzed in situ with transcriptional gusA reporter gene fusions. As a con... | ['Genes, Bacterial', 'Mutation', 'Peas', 'Rhizobium leguminosarum', 'Symbiosis'] | 11,310,734 | [['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.365.590'], ['B01.650.940.800.575.912.250.401.630'], ['B03.440.400.425.700.800.450', 'B03.585.900.450', 'B03.660.050.662.670.450'], ['G06.550.800', 'G16.840']] | ['Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Determination by high performance chromatography, steroid saponins in a biologically active food supplements containing the extract of Tribulus terrestris]. | Steroidal saponins are bioactive substances of Tribulus terrestris and can be used to assess the quality of raw materials and processed products from them. For this purpose has been developed the method of qualitative and quantitative determination of steroidal saponins by high performance liquid chromatography with sp... | ['Chromatography, High Pressure Liquid', 'Dietary Supplements', 'Mass Spectrometry', 'Plant Components, Aerial', 'Plant Extracts', 'Plants, Medicinal', 'Saponins', 'Steroids', 'Tribulus'] | 22,379,868 | [['E05.196.181.400.300'], ['G07.203.300.456', 'J02.500.456'], ['E05.196.566'], ['A18.024'], ['D20.215.784.500', 'D26.667'], ['B01.650.560'], ['D09.408.782'], ['D04.210.500'], ['B01.650.940.800.575.912.250.987.849']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Elevated serum neuron-specific enolase in patients with temporal lobe epilepsy: a video-EEG study. | Established markers of brain damage, neuron-specific enolase (NSE) and S-100b protein (S-100), may increase after status epilepticus, but whether a single tonic-clonic or complex partial seizure induces elevation of these markers is not known. Furthermore, it is unclear whether the risk of seizure-related neuronal dama... | ['Adult', 'Electroencephalography', 'Epilepsy, Temporal Lobe', 'Female', 'Humans', 'Immunoassay', 'Male', 'Middle Aged', 'Phosphopyruvate Hydratase', 'S100 Proteins', 'Statistics, Nonparametric', 'Time Factors', 'Video Recording', 'Young Adult'] | 18,595,663 | [['M01.060.116'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490.360.290', 'C10.228.140.490.493.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566', 'E05.601.470'], ['M01.060.116.630'], ['D08.811.520.241.300.500'], ['D12.776.157.125.750', 'D12.776.631.655'], ['E05.318.740.995', 'N05.715.36... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Fiducial-based targeting accuracy for external-beam radiotherapy. | The accuracy of fiducial-based alignment of external radiotherapy beams is analyzed. The study considers three basic computational methods to determine the target position--the exact closed-form solution for three fiducials, the solution via singular value decomposition for four or more fiducials, and the iterative sol... | ['Algorithms', 'Biophysical Phenomena', 'Biophysics', 'Humans', 'Models, Theoretical', 'Monte Carlo Method', 'Radiosurgery', 'Radiotherapy', 'Reproducibility of Results'] | 11,929,016 | [['G17.035', 'L01.224.050'], ['G01.154'], ['H01.158.344', 'H01.671.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['E02.815.530', 'E04.525.800.650', 'E05.873.500'], ['E02.815'], ['E05.318.370.725', 'E05.337.851',... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
The association between subjective maternal stress during pregnancy and offspring clinically diagnosed psychiatric disorders. | OBJECTIVE: Exposure to prenatal stress is a ubiquitous and non-specific risk factor for adverse outcomes in adulthood. In this study, we examined associations between exposure to subjective maternal stress during pregnancy and subsequent diagnosis of psychiatric disorders in offspring.METHOD: This study used the Helsin... | ['Adult', 'Anxiety Disorders', 'Female', 'Finland', 'Humans', 'Longitudinal Studies', 'Male', 'Mental Disorders', 'Mood Disorders', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Psychotic Disorders', 'Registries', 'Stress, Psychological'] | 30,548,544 | [['M01.060.116'], ['F03.080'], ['Z01.542.816.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['F03'], ['F03.600'], ['G08.686.784.769'], ['C13.703.824.500'], ['F03.700.675'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Completed suicide in Spain, 1906-1991. Geographical distribution of mortality]. | Suicidal behaviour in Spain, from the National Institute of Statistics (INE) data, is analysed. Provincial standardized figures of the first national study on Suicide (INE-1906) and those ones in 1991 (Spanish last Census), are compared. We discuss the consequences from the preventive approach. | ['Adolescent', 'Adult', 'Aged', 'Child', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Retrospective Studies', 'Sex Factors', 'Spain', 'Suicide'] | 8,686,565 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Adjustment of the endoscopic third ventriculostomy entry point based on the anatomical relationship between coronal and sagittal sutures. | OBJECT: The coronal suture is often used as an empirical landmark for the entry point for endoscopic third ventriculostomy. The trajectory for the approach is often drawn based on midsagittal MRI findings. However, because the coronal suture is not perpendicular to the midline, this method may be inaccurate.METHODS: Th... | ['Cadaver', 'Cranial Sutures', 'Frontal Bone', 'Humans', 'Magnetic Resonance Imaging', 'Neuroendoscopy', 'Parietal Bone', 'Third Ventricle', 'Ventriculostomy'] | 23,259,823 | [['C23.550.260.224'], ['A02.835.232.781.200'], ['A02.835.232.781.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E01.370.376.525', 'E01.370.388.250.700', 'E04.502.250.700', 'E04.525.562'], ['A02.835.232.781.651'], ['A08.186.211.140.840'], ['E04.035.188.957', 'E04.525.170.860']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Radiation therapy in the management of localized carcinoma of the prostate: a preliminary report. | Since 1970 a total of 107 patients has been treated radically with radiation therapy for carcinoma of the prostate. The local control with this form of treatment is over 90%. The five year actuarial survival is 74% and the disease-free survival 58%. Serious morbidity has been minimal. Survival is related to the extent ... | ['Acid Phosphatase', 'Aged', 'Digestive System', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Metastasis', 'Prostatic Neoplasms', 'Radiation Dosage', 'Radiotherapy, High-Energy', 'Remission, Spontaneous', 'Time Factors', 'Urinary Tract'] | 401,678 | [['D08.811.277.352.650.025'], ['M01.060.116.100'], ['A03'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.650', 'C23.550.727.650'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E02.815.722'], ['C2... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A comparative assessment of a new antacid formulation based on magaldrate. | A new antacid formulation (Dynese) based on magaldrate, a discrete chemical entity with marked antacid properties, has been compared in vitro with several commercially available antacid preparations. All preparations were tested for their ability to maintain gastric pH within acceptable limits and to effectively bind b... | ['Aluminum Hydroxide', 'Antacids', 'Bile Acids and Salts', 'Gastric Acid', 'Hydrogen-Ion Concentration', 'Magnesium', 'Magnesium Hydroxide', 'Sodium'] | 6,662,972 | [['D01.045.250.050', 'D01.056.037', 'D01.248.497.158.459.075'], ['D27.505.519.170', 'D27.505.954.483.080'], ['D04.210.500.105'], ['A12.200.307.603'], ['G02.300'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['D01.045.250.575', 'D01.248.497.158.459.388', 'D01.524.485'], ['D01.268.549.750', 'D01.268.557.65... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Use of transcranial micropolarization in the treatment of tension headaches]. | The study was made of effectiveness of transcranial micropolarization (TSMP) in the treatment of tension headache (TH). A course of TSMP was conducted in 33 TH patients. TSMP has relieved TH, anxiety, depression. Neither side effects nor complications occurred. | ['Adolescent', 'Adult', 'Electric Stimulation Therapy', 'Electroencephalography', 'Humans', 'Tension-Type Headache', 'Treatment Outcome'] | 12,380,527 | [['M01.060.057'], ['M01.060.116'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.546.399.875'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos. | The molecular mechanisms governing mitotic entry during animal development are incompletely understood. Here, we show that the mitotic kinase CDK-1 phosphorylates Suppressor of Par-Two 1 (SPAT-1)/Bora to regulate its interaction with PLK-1 and to trigger mitotic entry in early Caenorhabditis elegans embryos. Embryos ex... | ['Amino Acid Sequence', 'Animals', 'Aurora Kinase A', 'CDC2 Protein Kinase', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Cell Cycle Proteins', 'Embryo, Nonmammalian', 'Enzyme Activation', 'Humans', 'Larva', 'Mitosis', 'Molecular Sequence Data', 'Phosphorylation', 'Protein Processing, Post-Translationa... | 25,753,036 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D08.811.913.696.620.682.700.103.500', 'D12.776.167.049.500'], ['D08.811.913.696.620.682.700.646.500.500.250', 'D08.811.913.696.620.682.700.646.500.984.500', 'D12.644.360.250.067.249', 'D12.644.360.250.580.500', 'D12.776.167.200.067.249', 'D12.776.167.200.580.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
MIDORI server: a webserver for taxonomic assignment of unknown metazoan mitochondrial-encoded sequences using a curated database. | Summary: We present MIDORI server, a user-friendly web platform that uses a curated reference dataset, MIDORI, for high throughput taxonomic classification of unknown metazoan mitochondrial-encoded gene sequences. Currently three methods of taxonomic assignments: RDP Classifier, SPINGO and SINTAX, are implemented.Avail... | ['Animals', 'Computational Biology', 'Computers', 'Databases, Factual', 'Databases, Genetic', 'Genes, Mitochondrial', 'Internet', 'Software'] | 29,878,054 | [['B01.050'], ['H01.158.273.180', 'L01.313.124'], ['L01.224.230.260'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G05.360.340.024.340.365', 'G05.420.275.500'], ['L01.224.230.110.500'], ['L01.224.900']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Internucleobase-interaction-directed self-assembly of nanofibers from homo- and heteroditopic 1,omega-nucleobase bolaamphiphiles. | The complementary 1,omega-thymine, 1,omega-adenine, and 1,omega-(thymine, adenine) bolaamphiphiles, [N,N'-bis[3-(2,4-dihydroxy-5-methylpyrimidine-1-yl)propionyl]1,n-diaminoalkane [T-n-T (n = 10, 11, 12)], N, N'-bis[3-(6-aminopurine-9-yl)propionyl]1,n-diaminoalkane [A-n-A (n = 10, 11, 12)], and N-[3-(2,4-dihydroxy-5-met... | ['Adenine', 'Microscopy', 'Microscopy, Electron', 'Spectroscopy, Fourier Transform Infrared', 'Structure-Activity Relationship', 'Surface-Active Agents', 'Thymine', 'X-Ray Diffraction'] | 11,414,828 | [['D03.633.100.759.138'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['E01.370.350.515.402', 'E05.595.402'], ['E05.196.712.726.676.700', 'E05.196.867.826.676.700'], ['G02.111.830', 'G07.690.773.997'], ['D27.720.877'], ['D03.383.742.698.875.899'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.965']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Excitability increase in withdrawal interneurons after conditioning in snail. | Membrane mechanisms of conditioning of the defensive reflex in the snails Helix pomatia and H. lucorum were investigated. Tapping on the shell was used as a conditioned stimulus, which under normal conditions produces no defensive reaction. A light blow of air into the pneumostome, called the defensive closure reaction... | ['Action Potentials', 'Animals', 'Association Learning', 'Conditioning, Psychological', 'Helix, Snails', 'In Vitro Techniques', 'Interneurons', 'Membrane Potentials', 'Reflex'] | 9,512,399 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['F02.463.425.069.296'], ['F02.463.425.179'], ['B01.050.500.644.400.750.450'], ['E05.481'], ['A08.675.358', 'A11.671.358'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E01.370.376.550.650', 'E01.370.600.550.650', 'F02.830.702', 'G11.56... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Locations of the beta1 transmembrane helices in the BK potassium channel. | BK channels are composed of alpha-subunits, which form a voltage- and Ca(2+)-gated potassium channel, and of modulatory beta-subunits. The beta1-subunit is expressed in smooth muscle, where it renders the BK channel sensitive to [Ca(2+)](i) in a voltage range near the smooth-muscle resting potential and slows activatio... | ['Cysteine', 'Disulfides', 'Electrophysiology', 'Large-Conductance Calcium-Activated Potassium Channels', 'Models, Molecular', 'Muscle, Smooth', 'Protein Structure, Tertiary'] | 18,669,652 | [['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['H01.158.344.528', 'H01.158.782.236'], ['D12.776.157.530.400.600.150.500', 'D12.776.543.550.450.750.150.500', 'D12.776.543.585.400.750.150.500'], ['E05.599.595'], ['A02.... | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Self-aggregation of synthetic bacteriochlorophyll-d analogues possessing a B-ring reduced chlorin pi-system. | Zinc 3(1)-hydroxy-13(1)-oxo-chlorophyll derivatives 3 and 4 having a B-ring reduced chlorin pi-system (C7-C8, C17=C18) were prepared as models of self-aggregative bacteriochlorophyll-d, which are regioisomers of 1 and 2 possessing a natural-type D-ring reduced chlorin pi-system (C7=C8, C17-C18). 3(1)-Epimerically pure ... | ['Bacteriochlorophylls', 'Chromatography, High Pressure Liquid', 'Circular Dichroism', 'Crystallography, X-Ray', 'Magnetic Resonance Spectroscopy', 'Molecular Structure', 'Porphyrins', 'Spectrometry, Mass, Fast Atom Bombardment'] | 19,791,736 | [['D03.383.129.578.840.374.100', 'D03.633.400.909.374.100', 'D04.345.783.374.100', 'D12.776.752.249'], ['E05.196.181.400.300'], ['E05.196.867.151'], ['E05.196.309.742.225'], ['E05.196.867.519'], ['G02.111.570', 'G02.466'], ['D03.383.129.578.840.500', 'D03.633.400.909.500', 'D04.345.783.500', 'D23.767.727'], ['E05.196.5... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
3-Year follow-up results of bone mineral content and density after a school-based physical activity randomized intervention trial. | BACKGROUND: As an important modifiable lifestyle factor in osteoporosis prevention, physical activity has been shown to positively influence bone mass accrual during growth. We have previously shown that a nine month general school based physical activity intervention increased bone mineral content (BMC) and density (a... | ['Bone Density', 'Child', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Motor Activity', 'Schools'] | 23,510,752 | [['G11.427.100'], ['M01.060.406'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698'], ['I02.783', 'J03.832']] | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Staphylococcus aureus growth and survival during curding of Manchego type cheese produced with normal and subnormal starter activity. | Manchego type cheese was manufactured from milk from cows, goats and ewes artificially contaminated with 2 X 10(4) S. aureus cells ml. Lactic starter culture was added to the milk at the rate of 1.0 or 0.1% (v/v). the industrial process of Manchego type cheese manufacture was imitated. Cheeses were analyzed for both st... | ['Animals', 'Cattle', 'Cheese', 'Female', 'Food Handling', 'Food Microbiology', 'Goats', 'Milk', 'Sheep', 'Staphylococcus aureus'] | 3,590,995 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G07.203.200.500.444', 'G07.203.300.350.300.444', 'J02.350.500.444', 'J02.500.350.300.444'], ['J01.576.423.200'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300', 'N06.850.425.200', 'N06.850.460.400.300', 'N06.850.601.500.249.300'], ['B01.050.150.900... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Predicting success and long-term outcomes of percutaneous mitral valvuloplasty: a multifactorial score. | BACKGROUND: Percutaneous mitral valvuloplasty (PMV) success depends on appropriate patient selection. A multifactorial score derived from clinical, anatomic/echocardiographic, and hemodynamic variables would predict procedural success and clinical outcome.METHODS: Demographic data, echocardiographic parameters (includi... | ['Age Distribution', 'Catheterization', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Mitral Valve Stenosis', 'Predictive Value of Tests', 'Regression Analysis', 'Retrospective Studies', 'Risk Assessment', 'Sex Distribution', 'Treatment Outcome', 'Ultrasonography'] | 19,486,721 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['E02.148', 'E05.157'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.484.517'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.85... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Monitoring sepsis using electrical cell profiling. | Sepsis is a potentially lethal condition that may be ameliorated through early monitoring of circulating activated leukocytes for faster stratification of severity of illness and improved administration of targeted treatment. Characterization of the intrinsic electrical properties of leukocytes is label-free and can pr... | ['Animals', 'Electric Impedance', 'Electricity', 'Granulocytes', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Sepsis'] | 27,722,555 | [['B01.050'], ['G01.358.500.249.277.350'], ['G01.358.500.249'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['C01.757', 'C2... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Minimum-distance requirements could harm high-performing critical-access hospitals and rural communities. | Since the inception of the Medicare Rural Hospital Flexibility Program in 1997, over 1,300 rural hospitals have converted to critical-access hospitals, which entitles them to Medicare cost-based reimbursement instead of reimbursement based on the hospital prospective payment system (PPS). Several changes to eligibility... | ['Cost Savings', 'Economics, Hospital', 'Health Services Accessibility', 'Hospitals, Rural', 'Humans', 'Medicare', 'Reimbursement Mechanisms', 'Rural Population', 'United States'] | 25,847,646 | [['N03.219.151.160.200'], ['N03.219.262'], ['N04.590.374.350', 'N05.300.430'], ['N02.278.421.518'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.346.506.564.663', 'N03.219.521.576.343.840', 'N03.706.615.696'], ['N03.219.521.710.305'], ['N01.600.725'], ['Z01.107.567.875']] | ['Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Evaluation of cardiac ischemia by NADH fluroescence photography. | A direct, noninvasive method of assessing the oxidation-reduction potential of an intramyocardial respiratory chain component is described. The technique is based on the differences in spectral properties between the oxidized and reduced forms of nicotinamide adenine dinucleotide (NADH). The tissue surface fluorescence... | ['Animals', 'Coronary Disease', 'Fluoroscopy', 'Myocardium', 'NAD', 'Oxidation-Reduction', 'Photofluorography', 'Rabbits'] | 203,234 | [['B01.050'], ['C14.280.647.250', 'C14.907.585.250'], ['E01.370.350.700.225'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D03.633.100.759.646.138.694', 'D08.211.589', 'D13.695.667.138.694', 'D13.695.827.068.694'], ['G02.700', 'G03.295.531'], ['E01.370.350.600.625', 'E01.370.350.700.225.625'], ['B01.050.150.90... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The relative timing of trunk muscle activation is retained in response to unanticipated postural-perturbations during acute low back pain. | The purpose of this study was to assess the activation of the erector spinae (ES) and external oblique (EO) in response to unanticipated, bi-directional postural perturbations before and after the induction of acute low back pain (LBP) in healthy individuals. An experimental session consisted of a baseline, control, an... | ['Acute Disease', 'Adaptation, Physiological', 'Female', 'Humans', 'Low Back Pain', 'Male', 'Muscle Contraction', 'Muscle, Skeletal', 'Postural Balance', 'Reaction Time', 'Reflex', 'Time Factors', 'Young Adult'] | 21,442,223 | [['C23.550.291.125'], ['G07.025', 'G16.012.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.107.400'], ['G11.427.494'], ['A02.633.567', 'A10.690.552.500'], ['F02.830.816.541.752', 'G07.888.750.500', 'G11.427.690', 'G11.561.790.541.595'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.67... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Wastewater quality improvement through storage: a case study in Sicily. | This paper presents the results of a research aiming at evaluating the effects of storage on wastewater characteristics. Wastewater discharged from the Caltagirone (Eastern Sicily) plant after secondary treatment was stored in an earth reservoir with a capacity of about 25,000 m3 and a depth of 5 m. Wastewater inflow i... | ['Oxygen', 'Regression Analysis', 'Sicily', 'Waste Disposal, Fluid', 'Water Microbiology', 'Water Pollution', 'Water Purification'] | 12,793,677 | [['D01.268.185.550', 'D01.362.670'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['Z01.542.489.751', 'Z01.542.580.500.751', 'Z01.639.640.751'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['H01.158.273.540.274.777', 'N06.850.425.450'], ['N06.850.460.790'], ['N06.850.780.200.80... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
A comparative assessment of continuous production techniques to generate sub-micron size PLGA particles. | The clinical and commercial development of polymeric sub-micron size formulations based on poly(lactic-co-glycolic acid) (PLGA) particles is hampered by the challenges related to their good manufacturing practice (GMP)-compliant, scale-up production without affecting the formulation specifications. Continuous process t... | ['Chemistry, Pharmaceutical', 'Microfluidics', 'Nanoparticles', 'Particle Size', 'Polylactic Acid-Polyglycolic Acid Copolymer'] | 30,144,511 | [['H01.158.703.007', 'H01.181.466'], ['E05.830.666', 'H01.671.808.500', 'J01.897.520.500.500'], ['J01.637.512.600'], ['G02.712'], ['D02.241.511.459.450.500', 'D05.750.728.780.500', 'D25.720.728.780.500', 'J01.637.051.720.728.780.500']] | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Haemodynamic effects of clonidine injected epidurally in halothane-anaesthetized dogs. | The haemodynamic effects of clonidine administered in the epidural space were studied in 16 halothane-anaesthetized dogs. The animals were randomly assigned to two groups: Group I received three doses of 3 ml of normal saline, Group II received three doses of 3 micrograms X kg-1 of clonidine, through an epidural cathet... | ['Anesthesia', 'Animals', 'Blood Pressure', 'Cardiac Output', 'Clonidine', 'Dogs', 'Halothane', 'Heart Rate', 'Hemodynamics', 'Injections, Epidural', 'Myocardial Contraction'] | 3,829,284 | [['E03.155'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.150', 'G09.330.380.124'], ['D03.383.129.308.436.500'], ['B01.050.150.900.649.313.750.250.216.200'], ['D02.455.526.340'], ['E01.370.600.875.500', 'G09.330.380.500'], ['G09.330.380'], ['E02.319.267.530.580.300'], ['G09.330.580', 'G11... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cross-correlation analyses of nonlinear systems with spatiotemporal inputs. | Methods are presented for analyzing the low-order stimulus-response cross-correlation functions (or kernels) of visual neurons studied with spatiotemporal white noise. In particular, formulas are derived that relate the low-order kernels of a cell to its responses to single-drifting, double-drifting, and counterphase g... | ['Animals', 'Models, Neurological', 'Neurons', 'Nonlinear Dynamics', 'Visual Cortex'] | 8,307,593 | [['B01.050'], ['E05.599.395.642'], ['A08.675', 'A11.671'], ['E05.599.850', 'H01.548.675'], ['A08.186.211.200.885.287.500.571.735', 'A08.186.211.200.885.287.500.814.953']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
NoSQL data model for semi-automatic integration of ethnomedicinal plant data from multiple sources. | INTRODUCTION: Sharing traditional knowledge with the scientific community could refine scientific approaches to phytochemical investigation and conservation of ethnomedicinal plants. As such, integration of traditional knowledge with scientific data using a single platform for sharing is greatly needed. However, ethnom... | ['Data Interpretation, Statistical', 'Database Management Systems', 'Databases, Factual', 'Information Storage and Retrieval', 'Integrated Advanced Information Management Systems', 'Medicine, Traditional', 'Models, Statistical', 'Plants, Medicinal'] | 24,737,485 | [['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['L01.224.068', 'L01.224.900.280', 'N04.452.515.110'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['L01.313.500.750.280', 'L01.470'], ['L01.313.500.750.300.420'], ['E02.190.488', 'I01.076.201.450.654']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Mutational analysis of bacterial NAD+-dependent DNA ligase: role of motif IV in ligation catalysis. | The bacterial DNA ligase as a multiple domain protein is involved in DNA replication, repair and recombination. Its catalysis of ligation can be divided into three steps. To delineate the roles of amino acid residues in motif IV in ligation catalysis, site-directed mutants were constructed in a bacterial NAD+-dependent... | ['Amino Acid Motifs', 'Amino Acid Sequence', 'Base Pair Mismatch', 'Base Sequence', 'Catalysis', 'DNA Ligases', 'DNA Mutational Analysis', 'DNA, Bacterial', 'Escherichia coli', 'Kinetics', 'Mutagenesis, Site-Directed', 'Protein Structure, Tertiary', 'Substrate Specificity', 'Thermus', 'Transformation, Genetic'] | 17,687,496 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G05.365.590.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.130'], ['D08.811.074.500', 'D08.811.464.754.600'], ['E05.393.760.700.300'], ['D13.444.308.212'], ['B03.440.450.425.325.300', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of Ultrasound-Guided Placement of Difficult-to-Place Peripheral Venous Catheters: A Prospective Study of a Training Program for Nurse Anesthetists. | Patients with difficult intravenous access (DIVA) often experience discomfort because of failed attempts to place peripheral venous catheters (PVCs); however, ultrasound guidance may improve this problem with catheter placement. The aim of this study was to evaluate the use of ultrasound when operated by nurse anesthet... | ['Administration, Intravenous', 'Catheterization, Peripheral', 'Education, Nursing', 'Humans', 'Nurse Anesthetists', 'Prospective Studies', 'Ultrasonography, Interventional'] | 27,311,149 | [['E02.319.267.082'], ['E02.148.224', 'E04.100.814.529.937', 'E04.502.382.937', 'E05.157.375'], ['I02.358.462'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.140.650', 'M01.526.485.650.648.500', 'N02.360.140.650', 'N02.360.650.648.500'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Sex-related analysis of short- and long-term clinical outcomes and bleeding among patients treated with primary percutaneous coronary intervention: an evaluation of the RISK-PCI data. | BACKGROUND: Unfavourable effect of female sex on short- and long-term clinical outcomes has been demonstrated in unselected ST-elevation acute myocardial infarction (STEMI) patients; the results are conflicting in patients who undergo primary percutaneous coronary intervention (PPCI). The objective of this substudy was... | ['Age Factors', 'Cohort Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Longitudinal Studies', 'Male', 'Myocardial Infarction', 'Odds Ratio', 'Percutaneous Coronary Intervention', 'Postoperative Hemorrhage', 'Prognosis', 'Risk Assessment', 'Sex Factors', 'Treatment Outcome'] | 23,462,375 | [['N05.715.350.075', 'N06.850.490.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', '... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
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