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26548f0a805861520e4097b0f1fb278f | Among the anti-herpesvirus agents , aciclovir , valaciclovir , penciclovir , famciclovir , idoxuridine , trifluridine and brivudin are used in the treatment of herpes simplex virus and varicella-zoster virus infections , and ganciclovir , foscarnet , cidofovir , fomivirsen and maribavir ( the latter in the developmenta... | [
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"start": 63,... | [] | Antiviral drugs: current state of the art. The chemotherapy of virus infections has definitely come of age. There are now 15 antiviral agents that have been formally licensed for the treatment of human immunodeficiency virus infections (zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir, nevirapine, d... | null | ### Instruction:
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Antiviral drugs: current state of the art. The chemotherapy of virus infection... |
75080bf07d4ac4a75b2906ffb6f7e2f5 | The present study examined the efficacy of single and combined treatment with an anticholinesterase , tetrahydroaminoacridine ( i.p . ) , and a glycine-B site partial agonist , D-cycloserine ( i.p . ; a positive allosteric modulator of NMDA receptors ) , in alleviating the deficit in water maze spatial navigation induc... | [
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] | [] | Tetrahydroaminoacridine and D-cycloserine fail to alleviate the water maze spatial navigation defect induced by hippocampal inactivation. The present study examined the efficacy of single and combined treatment with an anticholinesterase , tetrahydroaminoacridine ( i.p . ) , and a glycine-B site partial agonist , D-cy... | null | ### Instruction:
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Tetrahydroaminoacridine and D-cycloserine fail to alleviate the water maze spa... |
401db5d57ea1f07ccd46d84bb8bb8049 | He was initially treated with combination chemotherapy regimen of vincristine , actinomycin-D and cyclophosphamide ( VAC therapy ) . | [
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] | [Rhabdomyosarcoma of the bladder: a case report]. A 15-year-old man with the chief complaint of general fatigue was referred to our hospital on November 11, 1993. Bilateral percutaneous nephrostomy was performed for postrenal anuria. X-ray examinations revealed a huge intrapelvic tumor, and it was histopathologically d... | null | ### Instruction:
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[Rhabdomyosarcoma of the bladder: a case report]. A 15-year-old man with the c... |
f1ece46f77c29a69c323b215cd8e3394 | However , when a lung mass was noted two months later , he started to receive combination chemotherapy consisting of cyclophosphamide , adriamycin , vincristine , and prednisolone every three months . | [
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[Lymphomatoid granulomatosis (LYG) occurring in a patient with follicular lymp... |
e35777804b1ff6dbcbf0e949717f6175 | Three patients treated initially with propranolol alone have required substitution of amiodarone due to refractory congestive heart failure . | [
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] | [] | The role of beta-blockade therapy for ventricular tachycardia induced with isoproterenol: a prospective analysis. Isoproterenol is sometimes required for ventricular tachycardia (VT) induction. However, the role of beta-blockade for treatment of such VT has not been critically assessed. The use of beta-blockade was eva... | null | ### Instruction:
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The role of beta-blockade therapy for ventricular tachycardia induced with iso... |
193a4f7cc44d0bf1d41f408cb02836dd | We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h , in the absence and presence of Somatostatin , at their EC50 concentrations , to evaluate membrane fatty acid-based functional lipidomics together with the follow-up of EGFR and MAPK signaling pathways . | [
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] | Effects of Somatostatin, Curcumin and Quercetin on the fatty acid profile of breast cancer cell membranes. We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h , in the absence and presence of Somatostatin , at their EC50 concentrations , to evaluate membrane fatty acid-based f... | null | ### Instruction:
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Effects of Somatostatin, Curcumin and Quercetin on the fatty acid profile of b... |
67940ddd11f2888bf4d0ebec3cb0846c | Following corneal scrapings and culture , topical 0.5 % moxifloxacin and 0.5 % tobramycin were administered hourly . | [
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] | A case of Stenotrophomonas maltophilia keratitis effectively treated with moxifloxacin. A 70-year-old man with a long history of diabetes mellitus presented to our hospital (Department of Ophthalmology, Sahm Yook Medical Center, Seoul, Korea) complaining of severe ocular pain and visual disturbance in his left eye that... | null | ### Instruction:
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A case of Stenotrophomonas maltophilia keratitis effectively treated with moxi... |
372093725b8ad8e4eb9b742e47c77bde | Combination treatment with cetuximab and nystatin selectively increased cetuximab uptake by tumor tissues , translating into potentiated antitumor efficacy of cetuximab in vivo ( A431 and A549 tumors ) . | [
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] | Enhancement of tumor uptake and therapeutic efficacy of EGFR-targeted antibody cetuximab and antibody-drug conjugates by cholesterol sequestration. Cetuximab, a monoclonal antibody (mAb) targeting the epidermal growth factor receptor (EGFR), has been intensively investigated as a promising cancer treatment strategy. Th... | null | ### Instruction:
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Enhancement of tumor uptake and therapeutic efficacy of EGFR-targeted antibody... |
b365bab924d6bf0ef690410647d720fa | The effects of combination therapy with chenodeoxycholic acid ( CDCA ) and simvastatin on serum cholestanol , low-density lipoprotein ( LDL ) cholesterol , and lathosterol levels were investigated in seven adult patients with cerebrotendinous xanthomatosis ( CTX ) who were on long-term treatment with CDCA . | [
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Effect of simvastatin in addition to chenodeoxycholic acid in patients with ce... |
7b04d23796fbc56edeec27c121cb1b84 | Paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) has been demonstrated to be highly effective in treating patients with advanced breast cancer , including those with anthracycline-resistant breast cancer , a fact that has led to efforts to combine paclitaxel and anthracyclines . | [
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] | Paclitaxel and doxorubicin in metastatic breast cancer. For the past decades the anthracyclines have been regarded as among the most active drugs for the treatment of metastatic breast cancer. However, the 5-year survival rate in patients with stage IV breast cancer continues to be below 20%, and new active drugs and d... | null | ### Instruction:
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Paclitaxel and doxorubicin in metastatic breast cancer. For the past decades t... |
1fb9d1f36c16f6d77468ee75a5f2ae85 | However , anastrozole , exemestane and letrozole are associated with significantly fewer endometrial cancers , as well as venous and arterial vascular events , when compared with tamoxifen [ 9 , 10 ] . | [
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... | [] | Erythema nodosum secondary to aromatase inhibitor use in breast cancer patients: case reports and review of the literature. Aromatase inhibitors (AI's) are increasingly being incorporated in the treatment strategy for hormone receptor positive breast cancer either alone or in combination with chemotherapy, biologics in... | null | ### Instruction:
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Erythema nodosum secondary to aromatase inhibitor use in breast cancer patient... |
ad345c4bc60ce36a29b6f52a115881c8 | Additivity , synergy , or competition was observed with MIS and rapamycin , AzadC , doxorubicin , cisplatin , and paclitaxel , suggesting that MIS in combination with selective targeted therapies might achieve greater activity against ovarian cancer than the use of each individual agent alone . | [
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] | Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic agents to inhibit human and mouse ovarian cancer. Mullerian Inhibiting Substance (MIS), a biological modifier that causes regression of Mullerian ducts in male embryos, is effective as a single agent in vitro and in vivo against human and mou... | null | ### Instruction:
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Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic ... |
57a9e7ca1b9724efbf1fafd942564c65 | There was no cytotoxic effect of cisplatin , ifosfamide , and etoposide . | [
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] | [] | Overcoming Chemoresistance of Pediatric Ependymoma by Inhibition of STAT3 Signaling. The long-term clinical outcome of pediatric intracranial epepdymoma is poor with a high rate of recurrence. One of the main reasons for this poor outcome is the tumor's inherent resistance to chemotherapy. Signal transducer and activat... | null | ### Instruction:
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Overcoming Chemoresistance of Pediatric Ependymoma by Inhibition of STAT3 Sign... |
42cce37378b8dbe6a3442b1745c7b50f | Several first-line phase III trials , as well as ongoing trials for which only preliminary results have been published , have fueled debates on the optimal dose and schedule ; these have focused not only on weekly vs q3-weeks paclitaxel , but also on other modifications and the advisability of adding bevacizumab . | [
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] | Carboplatin/Paclitaxel Induction in Ovarian Cancer: The Finer Points. The carboplatin/paclitaxel doublet remains the chemotherapy backbone for the initial treatment of ovarian cancer. This two-drug regimen, with carboplatin dosed using the Calvert formula, yielded convincing noninferior outcomes when compared with the ... | null | ### Instruction:
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Carboplatin/Paclitaxel Induction in Ovarian Cancer: The Finer Points. The carb... |
b6d7c3cad588456347fb22848316513b | The primary goal was achieve the correct estimation of the target plasma area against the topotecan concentration-time curve ( AUC ) in a 5 day course of cladribine followed by monitored topotecan in pediatric patients with recurrent/refractory AML . | [
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Topotecan exposure estimation in pediatric acute myeloid leukemia supported by... |
08fea7daedc8cf02c42589a462f38d3f | The management of EP is challenging : no standardized guidelines exist with literature suggesting cyclosporine or infliximab as first-line therapy . | [
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] | [] | Erythrodermic psoriasis successfully and rapidly treated with brodalumab: Report of two cases. Erythrodermic psoriasis (EP) is a rare form of the disease clinically characterized by a generalized erythema covering ≥90% of the body surface area (BSA). The management of EP is challenging : no standardized guidelines exis... | null | ### Instruction:
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Erythrodermic psoriasis successfully and rapidly treated with brodalumab: Repo... |
80c7f4882c16991297c45309ebb232da | As single agents , curcumin and metformin are reported to exhibit chemopreventive properties , in vitro as well as in patients with oral cancer . | [
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Curcumin and metformin-mediated chemoprevention of oral cancer is associated w... |
ac435f58e8e8d73f211ced3e471d8603 | Withdrawal rates were comparable to drug survival rates of other biological therapies and rates of adverse events were similar between brodalumab and ustekinumab . | [
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] | [] | Brodalumab for the Treatment of Moderate-to-Severe Plaque Psoriasis: An Evidence Review Group Evaluation of a NICE Single Technology Appraisal. As part of the National Institute for Health and Care Excellence single technology appraisal process, brodalumab was assessed to determine the clinical and cost effectiveness o... | null | ### Instruction:
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Brodalumab for the Treatment of Moderate-to-Severe Plaque Psoriasis: An Eviden... |
73f375202d3c607481204a1cf596ef1f | In patients with NPSLE , the use of high-dose corticosteroids is recommended in combination with immunosuppressants , such as mycophenolate mofetil and intravenous cyclophosphamide pulse therapy . | [
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] | [Neuropsychiatric Systemic Lupus Erythematosus]. Central nervous system damage, a major organ manifestation of systemic lupus erythematosus (SLE), causes significant morbidity and mortality. Designating this condition as neuropsychiatric SLE (NPSLE), the American College of Rheumatology defines it as involving the cent... | null | ### Instruction:
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[Neuropsychiatric Systemic Lupus Erythematosus]. Central nervous system damage... |
0e2eb0bb0954b8d253ac1dd2ee955a7a | Thirty-three women diagnosed with metastatic breast cancer participated in a phase 1 clinical trial of a new combination of cyclophosphamide ( CTX ) and mitoxantrone ( MXT ) , with dose escalation of paclitaxel . | [
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] | Longitudinal effects of high-dose chemotherapy and autologous stem cell transplantation on quality of life in the treatment of metastatic breast cancer. This study determined the effects of high-dose chemotherapy (HDCT) with autologous blood stem cell transplantation (ASCT) on quality of life (QL) in women with metasta... | null | ### Instruction:
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Longitudinal effects of high-dose chemotherapy and autologous stem cell transp... |
112d742207ec92e9605bd4b9e97d6d1f | These studies suggest a slight advantage to the combined approaches that contain flutamide and bicalutamide , but the lack of dramatic differences in outcome makes monotherapy reasonable , especially in patients with more indolent disease . | [
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The selection of hormonal therapy in prostate cancer: who, when, and for how l... |
f0fd86ae2bdccfc5615dc78c2ce3b232 | We examined the feasibility and safety of using paclitaxel and trastuzumab as maintenance therapy after high-dose chemotherapy ( HDC ) with autologous hematopoietic stem cell transplantation ( AHST ) for patients with HER2-positive metastatic breast cancer . | [
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Paclitaxel and Trastuzumab as Maintenance Therapy in Patients with HER2-Positi... |
e2479b892d8fca52c8cd8863160d5582 | Dual antiplatelet therapy with aspirin and clopidogrel ( the preferred thienopyridine because of its superior hematologic safety ) is recommended for at least 4 weeks to prevent subacute stent thrombosis with bare-metal stents and 3 to 6 months to prevent late-stent thrombosis with drug-eluting stents . | [
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a66cb578b3228b7980765b70f98fe955 | Furthermore , in non-metastatic castration-resistant prostate cancer ( M0 CRPC ) , two second-generation anti-androgens , apalutamide and enzalutamide , when used in combination with ADT , have demonstrated a significant benefit in metastasis-free survival . | [
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Recent trends in the management of advanced prostate cancer. Advanced prostate... |
7ff40a7350715bf8a611cc76cd640e6f | A screening method based on liquid chromatography-electrospray mass spectrometry for the simultaneous determination of six corticosteroids ( betamethasone 17-valerate BM 17-V , beclomethasone BC , beclomethasone dipropionate BCDP , methylprednisolone MP , budesonide BD , flunisolide FN ) was developed in order to contr... | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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LC-MS method for the simultaneous determination of six glucocorticoids in phar... |
af84f310891977875c182da890deca25 | Phase Ib Study of the Oral Proteasome Inhibitor Ixazomib ( MLN9708 ) and Fulvestrant in Advanced ER+ Breast Cancer Progressing on Fulvestrant . | [
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Phase Ib Study of the Oral Proteasome Inhibitor Ixazomib ( MLN9708 ) and Fulve... |
1a7d989c08fa3795bc567e8ab0166a64 | Second-Line Treatment of Her2-Positive Metastatic Breast Cancer : Trastuzumab beyond Progression or Lapatinib ? A Population Based Cohort Study . | [
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] | [] | Second-Line Treatment of Her2-Positive Metastatic Breast Cancer : Trastuzumab beyond Progression or Lapatinib ? A Population Based Cohort Study . The relative efficacy of lapatinib vs. continuing trastuzumab beyond progression (TBP) in HER2-positive metastatic breast cancer (MBC) patients, who progressed on first-line ... | https://pubmed.ncbi.nlm.nih.gov/26375590/ | ### Instruction:
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Second-Line Treatment of Her2-Positive Metastatic Breast Cancer : Trastuzumab ... |
45be342e88ac7d0acbb6a07c7492b952 | Pharmacokinetic studies showed that chronic lymphocytic leukemia involving more than 80 % of the bone marrow at study start was associated with lower trough concentrations of alemtuzumab and rituximab , and that higher trough serum concentrations of alemtuzumab were associated with complete bone marrow clearance . | [
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] | A phase I study of escalated dose subcutaneous alemtuzumab given weekly with rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma. This study assessed the safety and preliminary efficacy of escalated dose subcutaneous alemtuzumab in combination with rituximab in chronic lymphocytic leukemia. Tw... | https://pubmed.ncbi.nlm.nih.gov/23645694/ | ### Instruction:
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6faa0980ffdd775fe223d1da82940557 | Furthermore , the overall response rate for docetaxel in the intent-to-treat population ( 42.5 % ) is superior to the response rate of either doxorubicin as second-line therapy ( 29.3 % ) or paclitaxel ( Taxol ; Bristol-Myers Squibb Oncology , Princeton , NJ ) when used as first- or second-line therapy ( 29 % ) in meta... | [
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Docetaxel (Taxotere): an effective agent in the management of second-line brea... |
8b1bb23841ae2c6e696bac92e3c4182e | Correlation of lidocaine induced changes in bladder capacity , compliance and number of uninhibited contractions with improvement on oral oxybutynin was 70.6 % , 64.3 % and 66.7 % , respectively . | [
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] | [] | The effects of intravesical lidocaine on bladder dynamics of children with myelomeningocele. Other studies have suggested that intravesical lidocaine may temporarily improve bladder dynamics but details of these effects and their application to children have not been examined. We evaluated the effects of intravesical l... | https://pubmed.ncbi.nlm.nih.gov/11371945/ | ### Instruction:
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The effects of intravesical lidocaine on bladder dynamics of children with mye... |
25a7dedfa19e3aaf3f8c7c38492f1afa | Compared with risedronate alone , at 6 months , risedronate plus atorvastatin produced significantly greater increases in the bone mineral density of the lumbar spine ( 1.58 % versus 0.75 % , p < 0.05 ) . | [
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Statins have additive effects to vertebral bone mineral density in combination... |
04ad370c0e3ca668b9c417e2cfeafa8c | The anti-CD22 immunoconjugate , inotuzumab ozogamicin , and the anti-CD19 BiTE ( ® ) antibody , blinatumomab , have demonstrated impressive single agent activity in patients with relapsed or refractory B-ALL . | [
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] | [] | Novel targeted therapies in acute lymphoblastic leukemia. Chemotherapy alone cures only 25-45% of adult patients with acute lymphoblastic leukemia (ALL), making novel treatment agents and strategies desperately needed. The addition of monoclonal antibodies (rituximab, alemtuzumab, epratzumab) to chemotherapy has demons... | https://pubmed.ncbi.nlm.nih.gov/23841506/ | ### Instruction:
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Novel targeted therapies in acute lymphoblastic leukemia. Chemotherapy alone c... |
133efa52c486fb60a800ef6220185463 | Patients registered with the German ACC Registry with refractory ACC progressing after cytotoxic therapies were offered treatment with bevacizumab ( 5 mg/kg body weight i.v . every 21 days ) and oral capecitabine ( 950 mg/m(2 ) twice daily for 14 days followed by 7 days of rest ) in 2006 - 2008 . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical ... |
7ebb3f2cc13e75ceaad2830378a07a9f | Patients who had pathologically been proven to have measurable lesions were treated with paclitaxel ( 200 mg/m(2 ) for 3 h ) and carboplatin [ area under the concentration-time curve ( AUC = 6 ) ] on day 1 and in 21 day cycles . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Phase II study of paclitaxel and carboplatin in advanced gastric cancer previo... |
e3807edae1596e1c8d9abf185e0a3c2b | With regard to efficacy in metastatic disease , exemestane is superior to megestrol acetate after progression on tamoxifen . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Long-term efficacy and safety of exemestane in the treatment of breast cancer.... |
0c5e3efa2736c3c9b15160e5b87b1966 | Aim of the study was to measure plasma levels of specific miRNAs ( miRNA-223 , -150 , -21 and -126 ) after physician-driven cessation of chronic P2Y12 inhibition and to study differences in the expression levels of these miRNAs between the different oral P2Y12 inhibitors clopidogrel , prasugrel and ticagrelor , respect... | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Course of platelet miRNAs after cessation of P2Y12 antagonists. Circulating pl... |
186c1f47aa16e787370c97d07b302bc4 | Eligible patients received ramucirumab ( 10mg/kg ) + dacarbazine ( 1000 mg/m(2 ) ) ( Arm A ) or ramucirumab only ( 10mg/kg ) ( Arm B ) every 3 weeks . | [
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A phase 2 randomised study of ramucirumab (IMC-1121B) with or without dacarbaz... |
f1925d2766cc1edf272bbf736587e34d | The aim of this study was to investigate the mutagenic and antigenotoxic effects of different doses of the flavonoid , apigenin , alone and in combination with the antitumor drugs , cyclophosphamide and doxorubicin , in vitro and in vivo . | [
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The effect of apigenin on cyclophosphamide and doxorubicin genotoxicity in vit... |
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... | [] | Treatment of peripheral T-cell lymphoma: are we data driven or driving the data? Peripheral T-cell lymphomas (PTCL) are a group of uncommon and heterogeneous malignancies arising from a postthymic or mature T-lymphocyte. The treatment of PTCL remains a challenging endeavor. Compared with the more common aggressive B-ce... | https://pubmed.ncbi.nlm.nih.gov/23568456/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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aef93dee5953fbbbf30f53423ef2c08b | More effective regimens are urgently needed for squamous cell carcinoma of esophagus ( SCCE ) , therefore , we conducted a phase I/II trial of a combination of docetaxel , platinum , and fluorouracil ( TPF ) for treating metastatic SCCE . | [
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Phase I/II study of docetaxel/cisplatin/fluorouracil combination chemotherapy ... |
9dc9c448c1cfe0ae6228e1de335aa21a | Gemcitabine with cyclosporine or with tacrolimus exerts a synergistic effect and induces tolerance in the rat . | [
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Gemcitabine with cyclosporine or with tacrolimus exerts a synergistic effect a... |
a44da7163dbe0769202832b6392742c8 | Erythropoietin receptor expression and its relationship with trastuzumab response and resistance in HER2-positive breast cancer cells . | [
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Erythropoietin receptor expression and its relationship with trastuzumab respo... |
2f3b2589dc0ee0e5195219864acdb46e | Both paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) and ifosfamide have been demonstrated to be active agents in patients with clinically defined platinum-refractory ovarian cancer . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Rationale for examining the combination of paclitaxel and ifosfamide in the tr... |
4043013291b0d04e965a2d139866788c | All M. simiae complex species proved susceptible to clarithromycin and , to a lesser extent , rifabutin , clofazimine , streptomycin and moxifloxacin . | [
{
"span_id": 0,
"text": "clarithromycin",
"start": 52,
"end": 66,
"token_start": 8,
"token_end": 9
},
{
"span_id": 1,
"text": "rifabutin",
"start": 94,
"end": 103,
"token_start": 16,
"token_end": 17
},
{
"span_id": 2,
"text": "clofazimine",
"start"... | [] | Drug susceptibility testing and pharmacokinetics question current treatment regimens in Mycobacterium simiae complex disease. The Mycobacterium simiae complex bacteria can cause opportunistic infections in humans. In the case of definite disease, there are no evidence-based treatment regimens and outcomes are very disa... | https://pubmed.ncbi.nlm.nih.gov/22099521/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Drug susceptibility testing and pharmacokinetics question current treatment re... |
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