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26548f0a805861520e4097b0f1fb278f | Among the anti-herpesvirus agents , aciclovir , valaciclovir , penciclovir , famciclovir , idoxuridine , trifluridine and brivudin are used in the treatment of herpes simplex virus and varicella-zoster virus infections , and ganciclovir , foscarnet , cidofovir , fomivirsen and maribavir ( the latter in the developmenta... | [
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"start": 63,... | [] | Antiviral drugs: current state of the art. The chemotherapy of virus infections has definitely come of age. There are now 15 antiviral agents that have been formally licensed for the treatment of human immunodeficiency virus infections (zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir, nevirapine, d... | null | ### Instruction:
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Antiviral drugs: current state of the art. The chemotherapy of virus infection... |
75080bf07d4ac4a75b2906ffb6f7e2f5 | The present study examined the efficacy of single and combined treatment with an anticholinesterase , tetrahydroaminoacridine ( i.p . ) , and a glycine-B site partial agonist , D-cycloserine ( i.p . ; a positive allosteric modulator of NMDA receptors ) , in alleviating the deficit in water maze spatial navigation induc... | [
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] | [] | Tetrahydroaminoacridine and D-cycloserine fail to alleviate the water maze spatial navigation defect induced by hippocampal inactivation. The present study examined the efficacy of single and combined treatment with an anticholinesterase , tetrahydroaminoacridine ( i.p . ) , and a glycine-B site partial agonist , D-cy... | null | ### Instruction:
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Tetrahydroaminoacridine and D-cycloserine fail to alleviate the water maze spa... |
401db5d57ea1f07ccd46d84bb8bb8049 | He was initially treated with combination chemotherapy regimen of vincristine , actinomycin-D and cyclophosphamide ( VAC therapy ) . | [
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] | [Rhabdomyosarcoma of the bladder: a case report]. A 15-year-old man with the chief complaint of general fatigue was referred to our hospital on November 11, 1993. Bilateral percutaneous nephrostomy was performed for postrenal anuria. X-ray examinations revealed a huge intrapelvic tumor, and it was histopathologically d... | null | ### Instruction:
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[Rhabdomyosarcoma of the bladder: a case report]. A 15-year-old man with the c... |
f1ece46f77c29a69c323b215cd8e3394 | However , when a lung mass was noted two months later , he started to receive combination chemotherapy consisting of cyclophosphamide , adriamycin , vincristine , and prednisolone every three months . | [
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[Lymphomatoid granulomatosis (LYG) occurring in a patient with follicular lymp... |
e35777804b1ff6dbcbf0e949717f6175 | Three patients treated initially with propranolol alone have required substitution of amiodarone due to refractory congestive heart failure . | [
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] | [] | The role of beta-blockade therapy for ventricular tachycardia induced with isoproterenol: a prospective analysis. Isoproterenol is sometimes required for ventricular tachycardia (VT) induction. However, the role of beta-blockade for treatment of such VT has not been critically assessed. The use of beta-blockade was eva... | null | ### Instruction:
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The role of beta-blockade therapy for ventricular tachycardia induced with iso... |
193a4f7cc44d0bf1d41f408cb02836dd | We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h , in the absence and presence of Somatostatin , at their EC50 concentrations , to evaluate membrane fatty acid-based functional lipidomics together with the follow-up of EGFR and MAPK signaling pathways . | [
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] | Effects of Somatostatin, Curcumin and Quercetin on the fatty acid profile of breast cancer cell membranes. We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h , in the absence and presence of Somatostatin , at their EC50 concentrations , to evaluate membrane fatty acid-based f... | null | ### Instruction:
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Effects of Somatostatin, Curcumin and Quercetin on the fatty acid profile of b... |
67940ddd11f2888bf4d0ebec3cb0846c | Following corneal scrapings and culture , topical 0.5 % moxifloxacin and 0.5 % tobramycin were administered hourly . | [
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] | A case of Stenotrophomonas maltophilia keratitis effectively treated with moxifloxacin. A 70-year-old man with a long history of diabetes mellitus presented to our hospital (Department of Ophthalmology, Sahm Yook Medical Center, Seoul, Korea) complaining of severe ocular pain and visual disturbance in his left eye that... | null | ### Instruction:
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A case of Stenotrophomonas maltophilia keratitis effectively treated with moxi... |
372093725b8ad8e4eb9b742e47c77bde | Combination treatment with cetuximab and nystatin selectively increased cetuximab uptake by tumor tissues , translating into potentiated antitumor efficacy of cetuximab in vivo ( A431 and A549 tumors ) . | [
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] | Enhancement of tumor uptake and therapeutic efficacy of EGFR-targeted antibody cetuximab and antibody-drug conjugates by cholesterol sequestration. Cetuximab, a monoclonal antibody (mAb) targeting the epidermal growth factor receptor (EGFR), has been intensively investigated as a promising cancer treatment strategy. Th... | null | ### Instruction:
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Enhancement of tumor uptake and therapeutic efficacy of EGFR-targeted antibody... |
b365bab924d6bf0ef690410647d720fa | The effects of combination therapy with chenodeoxycholic acid ( CDCA ) and simvastatin on serum cholestanol , low-density lipoprotein ( LDL ) cholesterol , and lathosterol levels were investigated in seven adult patients with cerebrotendinous xanthomatosis ( CTX ) who were on long-term treatment with CDCA . | [
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Effect of simvastatin in addition to chenodeoxycholic acid in patients with ce... |
7b04d23796fbc56edeec27c121cb1b84 | Paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) has been demonstrated to be highly effective in treating patients with advanced breast cancer , including those with anthracycline-resistant breast cancer , a fact that has led to efforts to combine paclitaxel and anthracyclines . | [
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] | Paclitaxel and doxorubicin in metastatic breast cancer. For the past decades the anthracyclines have been regarded as among the most active drugs for the treatment of metastatic breast cancer. However, the 5-year survival rate in patients with stage IV breast cancer continues to be below 20%, and new active drugs and d... | null | ### Instruction:
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Paclitaxel and doxorubicin in metastatic breast cancer. For the past decades t... |
1fb9d1f36c16f6d77468ee75a5f2ae85 | However , anastrozole , exemestane and letrozole are associated with significantly fewer endometrial cancers , as well as venous and arterial vascular events , when compared with tamoxifen [ 9 , 10 ] . | [
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... | [] | Erythema nodosum secondary to aromatase inhibitor use in breast cancer patients: case reports and review of the literature. Aromatase inhibitors (AI's) are increasingly being incorporated in the treatment strategy for hormone receptor positive breast cancer either alone or in combination with chemotherapy, biologics in... | null | ### Instruction:
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Erythema nodosum secondary to aromatase inhibitor use in breast cancer patient... |
ad345c4bc60ce36a29b6f52a115881c8 | Additivity , synergy , or competition was observed with MIS and rapamycin , AzadC , doxorubicin , cisplatin , and paclitaxel , suggesting that MIS in combination with selective targeted therapies might achieve greater activity against ovarian cancer than the use of each individual agent alone . | [
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] | Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic agents to inhibit human and mouse ovarian cancer. Mullerian Inhibiting Substance (MIS), a biological modifier that causes regression of Mullerian ducts in male embryos, is effective as a single agent in vitro and in vivo against human and mou... | null | ### Instruction:
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Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic ... |
57a9e7ca1b9724efbf1fafd942564c65 | There was no cytotoxic effect of cisplatin , ifosfamide , and etoposide . | [
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] | [] | Overcoming Chemoresistance of Pediatric Ependymoma by Inhibition of STAT3 Signaling. The long-term clinical outcome of pediatric intracranial epepdymoma is poor with a high rate of recurrence. One of the main reasons for this poor outcome is the tumor's inherent resistance to chemotherapy. Signal transducer and activat... | null | ### Instruction:
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Overcoming Chemoresistance of Pediatric Ependymoma by Inhibition of STAT3 Sign... |
42cce37378b8dbe6a3442b1745c7b50f | Several first-line phase III trials , as well as ongoing trials for which only preliminary results have been published , have fueled debates on the optimal dose and schedule ; these have focused not only on weekly vs q3-weeks paclitaxel , but also on other modifications and the advisability of adding bevacizumab . | [
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] | Carboplatin/Paclitaxel Induction in Ovarian Cancer: The Finer Points. The carboplatin/paclitaxel doublet remains the chemotherapy backbone for the initial treatment of ovarian cancer. This two-drug regimen, with carboplatin dosed using the Calvert formula, yielded convincing noninferior outcomes when compared with the ... | null | ### Instruction:
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Carboplatin/Paclitaxel Induction in Ovarian Cancer: The Finer Points. The carb... |
b6d7c3cad588456347fb22848316513b | The primary goal was achieve the correct estimation of the target plasma area against the topotecan concentration-time curve ( AUC ) in a 5 day course of cladribine followed by monitored topotecan in pediatric patients with recurrent/refractory AML . | [
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Topotecan exposure estimation in pediatric acute myeloid leukemia supported by... |
08fea7daedc8cf02c42589a462f38d3f | The management of EP is challenging : no standardized guidelines exist with literature suggesting cyclosporine or infliximab as first-line therapy . | [
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] | [] | Erythrodermic psoriasis successfully and rapidly treated with brodalumab: Report of two cases. Erythrodermic psoriasis (EP) is a rare form of the disease clinically characterized by a generalized erythema covering ≥90% of the body surface area (BSA). The management of EP is challenging : no standardized guidelines exis... | null | ### Instruction:
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Erythrodermic psoriasis successfully and rapidly treated with brodalumab: Repo... |
80c7f4882c16991297c45309ebb232da | As single agents , curcumin and metformin are reported to exhibit chemopreventive properties , in vitro as well as in patients with oral cancer . | [
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Curcumin and metformin-mediated chemoprevention of oral cancer is associated w... |
ac435f58e8e8d73f211ced3e471d8603 | Withdrawal rates were comparable to drug survival rates of other biological therapies and rates of adverse events were similar between brodalumab and ustekinumab . | [
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] | [] | Brodalumab for the Treatment of Moderate-to-Severe Plaque Psoriasis: An Evidence Review Group Evaluation of a NICE Single Technology Appraisal. As part of the National Institute for Health and Care Excellence single technology appraisal process, brodalumab was assessed to determine the clinical and cost effectiveness o... | null | ### Instruction:
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Brodalumab for the Treatment of Moderate-to-Severe Plaque Psoriasis: An Eviden... |
73f375202d3c607481204a1cf596ef1f | In patients with NPSLE , the use of high-dose corticosteroids is recommended in combination with immunosuppressants , such as mycophenolate mofetil and intravenous cyclophosphamide pulse therapy . | [
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] | [Neuropsychiatric Systemic Lupus Erythematosus]. Central nervous system damage, a major organ manifestation of systemic lupus erythematosus (SLE), causes significant morbidity and mortality. Designating this condition as neuropsychiatric SLE (NPSLE), the American College of Rheumatology defines it as involving the cent... | null | ### Instruction:
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[Neuropsychiatric Systemic Lupus Erythematosus]. Central nervous system damage... |
0e2eb0bb0954b8d253ac1dd2ee955a7a | Thirty-three women diagnosed with metastatic breast cancer participated in a phase 1 clinical trial of a new combination of cyclophosphamide ( CTX ) and mitoxantrone ( MXT ) , with dose escalation of paclitaxel . | [
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] | Longitudinal effects of high-dose chemotherapy and autologous stem cell transplantation on quality of life in the treatment of metastatic breast cancer. This study determined the effects of high-dose chemotherapy (HDCT) with autologous blood stem cell transplantation (ASCT) on quality of life (QL) in women with metasta... | null | ### Instruction:
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Longitudinal effects of high-dose chemotherapy and autologous stem cell transp... |
112d742207ec92e9605bd4b9e97d6d1f | These studies suggest a slight advantage to the combined approaches that contain flutamide and bicalutamide , but the lack of dramatic differences in outcome makes monotherapy reasonable , especially in patients with more indolent disease . | [
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The selection of hormonal therapy in prostate cancer: who, when, and for how l... |
f0fd86ae2bdccfc5615dc78c2ce3b232 | We examined the feasibility and safety of using paclitaxel and trastuzumab as maintenance therapy after high-dose chemotherapy ( HDC ) with autologous hematopoietic stem cell transplantation ( AHST ) for patients with HER2-positive metastatic breast cancer . | [
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Paclitaxel and Trastuzumab as Maintenance Therapy in Patients with HER2-Positi... |
e2479b892d8fca52c8cd8863160d5582 | Dual antiplatelet therapy with aspirin and clopidogrel ( the preferred thienopyridine because of its superior hematologic safety ) is recommended for at least 4 weeks to prevent subacute stent thrombosis with bare-metal stents and 3 to 6 months to prevent late-stent thrombosis with drug-eluting stents . | [
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a66cb578b3228b7980765b70f98fe955 | Furthermore , in non-metastatic castration-resistant prostate cancer ( M0 CRPC ) , two second-generation anti-androgens , apalutamide and enzalutamide , when used in combination with ADT , have demonstrated a significant benefit in metastasis-free survival . | [
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Recent trends in the management of advanced prostate cancer. Advanced prostate... |
7ff40a7350715bf8a611cc76cd640e6f | A screening method based on liquid chromatography-electrospray mass spectrometry for the simultaneous determination of six corticosteroids ( betamethasone 17-valerate BM 17-V , beclomethasone BC , beclomethasone dipropionate BCDP , methylprednisolone MP , budesonide BD , flunisolide FN ) was developed in order to contr... | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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LC-MS method for the simultaneous determination of six glucocorticoids in phar... |
af84f310891977875c182da890deca25 | Phase Ib Study of the Oral Proteasome Inhibitor Ixazomib ( MLN9708 ) and Fulvestrant in Advanced ER+ Breast Cancer Progressing on Fulvestrant . | [
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Phase Ib Study of the Oral Proteasome Inhibitor Ixazomib ( MLN9708 ) and Fulve... |
1a7d989c08fa3795bc567e8ab0166a64 | Second-Line Treatment of Her2-Positive Metastatic Breast Cancer : Trastuzumab beyond Progression or Lapatinib ? A Population Based Cohort Study . | [
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] | [] | Second-Line Treatment of Her2-Positive Metastatic Breast Cancer : Trastuzumab beyond Progression or Lapatinib ? A Population Based Cohort Study . The relative efficacy of lapatinib vs. continuing trastuzumab beyond progression (TBP) in HER2-positive metastatic breast cancer (MBC) patients, who progressed on first-line ... | https://pubmed.ncbi.nlm.nih.gov/26375590/ | ### Instruction:
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Second-Line Treatment of Her2-Positive Metastatic Breast Cancer : Trastuzumab ... |
45be342e88ac7d0acbb6a07c7492b952 | Pharmacokinetic studies showed that chronic lymphocytic leukemia involving more than 80 % of the bone marrow at study start was associated with lower trough concentrations of alemtuzumab and rituximab , and that higher trough serum concentrations of alemtuzumab were associated with complete bone marrow clearance . | [
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] | A phase I study of escalated dose subcutaneous alemtuzumab given weekly with rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma. This study assessed the safety and preliminary efficacy of escalated dose subcutaneous alemtuzumab in combination with rituximab in chronic lymphocytic leukemia. Tw... | https://pubmed.ncbi.nlm.nih.gov/23645694/ | ### Instruction:
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6faa0980ffdd775fe223d1da82940557 | Furthermore , the overall response rate for docetaxel in the intent-to-treat population ( 42.5 % ) is superior to the response rate of either doxorubicin as second-line therapy ( 29.3 % ) or paclitaxel ( Taxol ; Bristol-Myers Squibb Oncology , Princeton , NJ ) when used as first- or second-line therapy ( 29 % ) in meta... | [
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Docetaxel (Taxotere): an effective agent in the management of second-line brea... |
8b1bb23841ae2c6e696bac92e3c4182e | Correlation of lidocaine induced changes in bladder capacity , compliance and number of uninhibited contractions with improvement on oral oxybutynin was 70.6 % , 64.3 % and 66.7 % , respectively . | [
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] | [] | The effects of intravesical lidocaine on bladder dynamics of children with myelomeningocele. Other studies have suggested that intravesical lidocaine may temporarily improve bladder dynamics but details of these effects and their application to children have not been examined. We evaluated the effects of intravesical l... | https://pubmed.ncbi.nlm.nih.gov/11371945/ | ### Instruction:
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The effects of intravesical lidocaine on bladder dynamics of children with mye... |
25a7dedfa19e3aaf3f8c7c38492f1afa | Compared with risedronate alone , at 6 months , risedronate plus atorvastatin produced significantly greater increases in the bone mineral density of the lumbar spine ( 1.58 % versus 0.75 % , p < 0.05 ) . | [
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Statins have additive effects to vertebral bone mineral density in combination... |
04ad370c0e3ca668b9c417e2cfeafa8c | The anti-CD22 immunoconjugate , inotuzumab ozogamicin , and the anti-CD19 BiTE ( ® ) antibody , blinatumomab , have demonstrated impressive single agent activity in patients with relapsed or refractory B-ALL . | [
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] | [] | Novel targeted therapies in acute lymphoblastic leukemia. Chemotherapy alone cures only 25-45% of adult patients with acute lymphoblastic leukemia (ALL), making novel treatment agents and strategies desperately needed. The addition of monoclonal antibodies (rituximab, alemtuzumab, epratzumab) to chemotherapy has demons... | https://pubmed.ncbi.nlm.nih.gov/23841506/ | ### Instruction:
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Novel targeted therapies in acute lymphoblastic leukemia. Chemotherapy alone c... |
133efa52c486fb60a800ef6220185463 | Patients registered with the German ACC Registry with refractory ACC progressing after cytotoxic therapies were offered treatment with bevacizumab ( 5 mg/kg body weight i.v . every 21 days ) and oral capecitabine ( 950 mg/m(2 ) twice daily for 14 days followed by 7 days of rest ) in 2006 - 2008 . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical ... |
7ebb3f2cc13e75ceaad2830378a07a9f | Patients who had pathologically been proven to have measurable lesions were treated with paclitaxel ( 200 mg/m(2 ) for 3 h ) and carboplatin [ area under the concentration-time curve ( AUC = 6 ) ] on day 1 and in 21 day cycles . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Phase II study of paclitaxel and carboplatin in advanced gastric cancer previo... |
e3807edae1596e1c8d9abf185e0a3c2b | With regard to efficacy in metastatic disease , exemestane is superior to megestrol acetate after progression on tamoxifen . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Long-term efficacy and safety of exemestane in the treatment of breast cancer.... |
0c5e3efa2736c3c9b15160e5b87b1966 | Aim of the study was to measure plasma levels of specific miRNAs ( miRNA-223 , -150 , -21 and -126 ) after physician-driven cessation of chronic P2Y12 inhibition and to study differences in the expression levels of these miRNAs between the different oral P2Y12 inhibitors clopidogrel , prasugrel and ticagrelor , respect... | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Course of platelet miRNAs after cessation of P2Y12 antagonists. Circulating pl... |
186c1f47aa16e787370c97d07b302bc4 | Eligible patients received ramucirumab ( 10mg/kg ) + dacarbazine ( 1000 mg/m(2 ) ) ( Arm A ) or ramucirumab only ( 10mg/kg ) ( Arm B ) every 3 weeks . | [
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A phase 2 randomised study of ramucirumab (IMC-1121B) with or without dacarbaz... |
f1925d2766cc1edf272bbf736587e34d | The aim of this study was to investigate the mutagenic and antigenotoxic effects of different doses of the flavonoid , apigenin , alone and in combination with the antitumor drugs , cyclophosphamide and doxorubicin , in vitro and in vivo . | [
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The effect of apigenin on cyclophosphamide and doxorubicin genotoxicity in vit... |
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... | [] | Treatment of peripheral T-cell lymphoma: are we data driven or driving the data? Peripheral T-cell lymphomas (PTCL) are a group of uncommon and heterogeneous malignancies arising from a postthymic or mature T-lymphocyte. The treatment of PTCL remains a challenging endeavor. Compared with the more common aggressive B-ce... | https://pubmed.ncbi.nlm.nih.gov/23568456/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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aef93dee5953fbbbf30f53423ef2c08b | More effective regimens are urgently needed for squamous cell carcinoma of esophagus ( SCCE ) , therefore , we conducted a phase I/II trial of a combination of docetaxel , platinum , and fluorouracil ( TPF ) for treating metastatic SCCE . | [
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Phase I/II study of docetaxel/cisplatin/fluorouracil combination chemotherapy ... |
9dc9c448c1cfe0ae6228e1de335aa21a | Gemcitabine with cyclosporine or with tacrolimus exerts a synergistic effect and induces tolerance in the rat . | [
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Gemcitabine with cyclosporine or with tacrolimus exerts a synergistic effect a... |
a44da7163dbe0769202832b6392742c8 | Erythropoietin receptor expression and its relationship with trastuzumab response and resistance in HER2-positive breast cancer cells . | [
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Erythropoietin receptor expression and its relationship with trastuzumab respo... |
2f3b2589dc0ee0e5195219864acdb46e | Both paclitaxel ( Taxol ; Bristol-Myers Squibb Company , Princeton , NJ ) and ifosfamide have been demonstrated to be active agents in patients with clinically defined platinum-refractory ovarian cancer . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Rationale for examining the combination of paclitaxel and ifosfamide in the tr... |
4043013291b0d04e965a2d139866788c | All M. simiae complex species proved susceptible to clarithromycin and , to a lesser extent , rifabutin , clofazimine , streptomycin and moxifloxacin . | [
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"start"... | [] | Drug susceptibility testing and pharmacokinetics question current treatment regimens in Mycobacterium simiae complex disease. The Mycobacterium simiae complex bacteria can cause opportunistic infections in humans. In the case of definite disease, there are no evidence-based treatment regimens and outcomes are very disa... | https://pubmed.ncbi.nlm.nih.gov/22099521/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Drug susceptibility testing and pharmacokinetics question current treatment re... |
78070d46a5752185cc2d9f118c577564 | Drug exposure of mesenchymal HCC cells showed higher resistance to the targeted therapeutic agents sorafenib and erlotinib as compared to epithelial HCC cells , which were slightly more resistant to cytostatic drugs . | [
{
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{
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] | [] | A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression. The epithelial to mesenchymal transition (EMT) of malignant hepatocytes is a crucial event in hepatocellular carcinoma (HCC) progression and recurrence. We aimed to establish a human model of EMT to e... | https://pubmed.ncbi.nlm.nih.gov/21364009/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A human model of epithelial to mesenchymal transition to monitor drug efficacy... |
9d29356786d19764fd35e5c55994cb45 | To compare the effectiveness and safety of adalimumab and infliximab in biologic-naïve patients with CD , in a nationwide register-based propensity score-matched cohort study in Denmark . | [
{
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{
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] | [] | Comparison of infliximab with adalimumab in 827 biologic-naïve patients with Crohn's disease: a population-based Danish cohort study. There are conflicting data on comparative effectiveness of adalimumab and infliximab in patients with Crohn's disease (CD). ### aims To compare the effectiveness and safety of adalimumab... | https://pubmed.ncbi.nlm.nih.gov/29239001/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Comparison of infliximab with adalimumab in 827 biologic-naïve patients with C... |
f9e6f79e5313dcceeafb28a5d3c04a7b | Hematologic National Cancer Institute Common Toxicity Criteria grade 3 to 4 adverse events were more common with bendamustine than with chlorambucil ( occurring in 40 % v 19 % of patients ) . | [
{
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},
{
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"text": "chlorambucil",
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] | [] | Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. This randomized, open-label, parallel-group, multicenter study was designed to compare the efficacy and safety of bendamustine and chlorambucil in previously untreated patients with ... | https://pubmed.ncbi.nlm.nih.gov/19652068/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Phase III randomized study of bendamustine compared with chlorambucil in previ... |
9f41b57d1dbe5a07e388863d29a381a2 | We determined the effects of diclofenac sodium , octreotide , and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice . | [
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{
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] | [
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] | Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein. We determined the effects of diclofenac sodium , octreotide , and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice . ### methods A tota... | https://pubmed.ncbi.nlm.nih.gov/30515205/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Mu... |
5ad27773a3ec299ab3f8bcf2f358c135 | Caspofungin and amphotericin B association has been shown to be synergistic in vitro and effective in murine models . | [
{
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] | [Successful treatment of a persistent rhino-cerebral mucormycosis in a pediatric patient with a debut of acute lymphoblastic leukemia]. The fungi of the order Mucorales cause mucormycosis, which usually presents as an invasive fungal disease with rapid angioinvasion in immunocompromised patients. Rhinocerebral is the m... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
[Successful treatment of a persistent rhino-cerebral mucormycosis in a pediatr... |
e1316656233af591253a96acba045ca5 | Canine leishmaniosis is most frequently treated with the drugs meglumine antimoniate , allopurinol , amphotericin B , or a combination of meglumine antimoniate and allopurinol . | [
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] | Chemotherapy of canine leishmaniosis. Visceral leishmaniosis is a widespread and potentially fatal disease of dogs and humans common in the Mediterranean region, the Middle East, and South America. Canine leishmaniosis is most frequently treated with the drugs meglumine antimoniate , allopurinol , amphotericin B , or a... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Chemotherapy of canine leishmaniosis. Visceral leishmaniosis is a widespread a... |
56d69e4f3b906e7c44c8241207cf7be6 | Haloperidol , carbamazepine and levomepromazine were then discontinued . | [
{
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{
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] | Pituitary microadenoma treated with antipsychotic drug aripiprazole. Male patient 24 years old with a pituitary microadenoma and mental and behavioural disorders due to multiple drug use and use of other psychoactive substances (cocaine, cannabis and alcohol) were treated with haloperidol (dopamine receptor blocker) 10... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Pituitary microadenoma treated with antipsychotic drug aripiprazole. Male pati... |
02cd54bccbdd558f7e6bc91910d42d6d | Recent clinical work has questioned the safety of a combined therapy of oral quinidine and intravenous verapamil , because some patients were reported to react with severe hypotension probably due to drug interactions with vascular alpha-adrenergic receptors . | [
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] | [
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] | Additive competitive interaction of verapamil and quinidine at alpha-adrenergic receptors of isolated cardiac guinea pig myocytes and human platelets. Recent clinical work has questioned the safety of a combined therapy of oral quinidine and intravenous verapamil , because some patients were reported to react with sev... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Additive competitive interaction of verapamil and quinidine at alpha-adrenergi... |
78214ae4a7c12afa3da296121dce7807 | The mean duration of total ( i.v . and oral ) therapy was significantly shorter for the azithromycin group than for the cefuroxime group ( 6.2 days vs 10.1 days ) . | [
{
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{
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] | [] | Clinical efficacy and safety of a short regimen of azithromycin sequential therapy vs standard cefuroxime sequential therapy in the treatment of community-acquired pneumonia: an international, randomized, open-label study. An international, randomized, open-label, comparative study was undertaken in order to assess the... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Clinical efficacy and safety of a short regimen of azithromycin sequential the... |
7ab70148e0d2476ff23e259f31c9296e | To increase the dose-intensity of two drugs in metastatic breast cancer , we tested the feasibility , in phase I studies , of two schedules of epirubicin ( E ) and cyclophosphamide ( C ) - sequential ( E-- > C ) and alternating ( E/C ) - with respect to the standard combination ( EC ) . | [
{
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{
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] | [
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] | The impact of schedule on acute toxicity and dose-intensity of high-dose chemotherapy with epirubicin and cyclophosphamide plus colony stimulating factors in advanced breast cancer. To increase the dose-intensity of two drugs in metastatic breast cancer , we tested the feasibility , in phase I studies , of two schedul... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
The impact of schedule on acute toxicity and dose-intensity of high-dose chemo... |
55905a93b140ba124c6d5f6a8048e7cd | On February 3 , 2015 , the FDA granted accelerated approval to palbociclib ( IBRANCE , Pfizer Inc. ) , an inhibitor of cyclin-dependent kinases 4 and 6 ( CDK4 and CDK6 ) , for use in combination with letrozole for the treatment of postmenopausal women with estrogen receptor (ER)-positive , HER2-negative advanced breast... | [
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{
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] | [
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] | FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor-Positive, HER2-Negative Metastatic Breast Cancer. On February 3 , 2015 , the FDA granted accelerated approval to palbociclib ( IBRANCE , Pfizer Inc. ) , an inhibitor of cyclin-dependent kinases 4 and 6 ( CDK4 and CDK6 ) , for... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Es... |
91531be71fcd789d55fde620412620cc | a combination treatment : estramustine phosphate , cyproterone acetate or estrogens plus bromocriptine . | [
{
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{
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{
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] | [Current aspects of hormonal therapy in prostate cancer]. The following endocrine treatment modalities have been used in advanced prostatic carcinoma: 1. orchiectomy plus estrogens; 2. primary orchiectomy with delayed estrogen employment; 3. initial estrogen therapy with delayed orchiectomy; 4. initial cyproterone acet... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
[Current aspects of hormonal therapy in prostate cancer]. The following endocr... |
a8de81b4cbe9501ded6c855ae5e36b28 | Hormone induced elevations in temperature and possibly other unidentified factors during thyroid crisis may facilitate the triggering of MH following halothane and succinylcholine challenge . | [
{
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] | [
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] | Differential diagnosis of thyroid crisis and malignant hyperthermia in an anesthetized porcine model. The intra-operative differential diagnosis between thyroid crisis and malignant hyperthermia can be difficult. Also stress alone can trigger MH. The purposes of this study were: 1) to investigate the metabolic and hemo... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Differential diagnosis of thyroid crisis and malignant hyperthermia in an anes... |
290cf7b2e12423a284bce59adc4db1bf | Mitomycin C plus vinblastine is an effective and well-tolerated regimen for anthracycline resistant cancer . | [
{
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] | Mitomycin C and vinblastine in anthracycline-resistant metastatic breast cancer: a phase II study. The purpose of this phase II study was to evaluate the clinical efficacy of mitomycin C and vinblastine in patients with anthracycline-resistant metastatic breast cancer. This single-center, non-randomized trial enrolled ... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Mitomycin C and vinblastine in anthracycline-resistant metastatic breast cance... |
b0eb9d479b021a567638acb562ded0df | An angiotensin 2 type 1 receptor blocker , olmesartan , and a calcium channel blocker , azelnidipine , possess not only an antihypertensive effect but also an antioxidative effect and other beneficial effects . | [
{
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] | Synergistic neuroprotective effects of combined treatment with olmesartan plus azelnidipine in stroke-prone spontaneously hypertensive rats. An angiotensin 2 type 1 receptor blocker , olmesartan , and a calcium channel blocker , azelnidipine , possess not only an antihypertensive effect but also an antioxidative effec... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Synergistic neuroprotective effects of combined treatment with olmesartan plus... |
67f94ec99205e319ec06899312f45e8f | Forty patients with metastatic breast cancer who had received no previous cytotoxic therapy were treated with a combination chemotherapy program CMF ( P ) , which included methotrexate , 60 mg/m2 , and 5-fluorouracil , 700 mg/m2 intravenously on the first and eighth days , in addition to cyclophosphamide , 100 mg/m2 , ... | [
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{
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{
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... | [
{
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] | Combination chemotherapy for advanced breast cancer: response and effect on survival. Forty patients with metastatic breast cancer who had received no previous cytotoxic therapy were treated with a combination chemotherapy program CMF ( P ) , which included methotrexate , 60 mg/m2 , and 5-fluorouracil , 700 mg/m2 intr... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Combination chemotherapy for advanced breast cancer: response and effect on su... |
7c23493ded73984347e6db7d0d161392 | At present , it seems to us that progress has not been made since Grignani reported a phase II cohort trial of sorafenib and sorafenib combined with everolimus for advanced osteosarcoma , which , in a sense , have become a milestone as a second-line therapy for osteosarcoma . | [
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{
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{
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] | Anti-angiogenesis target therapy for advanced osteosarcoma (Review). Osteosarcomas (OS), especially those with metastatic or unresectable disease, have limited treatment options. The greatest advancement in treatments occurred in the 1980s when multi-agent chemotherapy, including doxorubicin, cisplatin, high-dose metho... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Anti-angiogenesis target therapy for advanced osteosarcoma (Review). Osteosarc... |
0c79def432df905a1e8d84e8539054d9 | Failure to sedate patients who might be aware of paralysis occurred in three of 25 succinylcholine and eight of 94 pancuronium uses . | [
{
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{
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] | [] | Neuromuscular blockade for critical patients in the emergency department. This retrospective study examines the indications and the effects of 119 doses of succinylcholine or pancuronium given in the emergency department during a 24-month period to patients considered to have immediately life-threatening emergencies. T... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Neuromuscular blockade for critical patients in the emergency department. This... |
24e63c61b098a59e672cadbad22bbe1e | Thirty-one isolates were classified as resistant to amprolium , 23 resistant to monensin , 10 resistant to diclazuril , and 6 resistant to clopidol . | [
{
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"start": 139,... | [] | Sensitivity of isolates of Eimeria from turkey flocks to the anticoccidial drugs amprolium, clopidol, diclazuril, and monensin. The sensitivity of field isolates of turkey coccidia from the United States to the anticoccidial drugs amprolium, clopidol, diclazuril, and monensin was investigated. clopidol and diclazuril w... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Sensitivity of isolates of Eimeria from turkey flocks to the anticoccidial dru... |
0e23f19dad084cb3a722f3e520128414 | Thirteen patients with interstitial cystitis diagnosed by the NIH criteria were treated with intravesical electromotive administration of lidocaine and dexamethasone followed by cystodistention . | [
{
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{
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{
"span_id": 2,
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... | [
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] | Electromotive drug administration and hydrodistention for the treatment of interstitial cystitis. Thirteen patients with interstitial cystitis diagnosed by the NIH criteria were treated with intravesical electromotive administration of lidocaine and dexamethasone followed by cystodistention . After a mean follow-up of... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Electromotive drug administration and hydrodistention for the treatment of int... |
8029f6b883c38288c2c68dc356e36630 | Drug therapy included omega-3 fish oil , extended-release niacin , colesevelam hydrochloride , and a fixed combination of 10-mg ezetimibe and 40-mg simvastatin . | [
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{
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] | Lipoprotein-associated phospholipase A2 mass is significantly reduced in dyslipidemic patients treated with lifestyle modification and combination lipid-modifying drug therapy. Lipoprotein-associated phospholipase A2 (Lp-PLA(2)) mass is a novel inflammatory biomarker. In human blood, Lp-PLA(2) is predominately associat... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Lipoprotein-associated phospholipase A2 mass is significantly reduced in dysli... |
fb72460a3108fabc35b87b9907696656 | Twenty-one Japanese colorectal cancer patients received intravenous FOLFIRI ( bolus irinotecan , folinic acid , and fluorouracil followed by 46-hour fluorouracil infusion ) followed by bevacizumab ( 5 mg/kg ) in Cycle 1 . | [
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] | Pharmacokinetics, safety, and efficacy of FOLFIRI plus bevacizumab in Japanese colorectal cancer patients with UGT1A1 gene polymorphisms. Previous reports of the influence of UGT1A1 gene polymorphisms on the pharmacokinetics of irinotecan metabolism have not assessed Asian patients treated with FOLFIRI plus bevacizumab... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Pharmacokinetics, safety, and efficacy of FOLFIRI plus bevacizumab in Japanese... |
946b6c730d129f5629f71b419dc0fb41 | Patients received vinorelbine starting at 20 mg/m(2 ) ( to 25 mg/m(2 ) ) and carboplatin area under the curve ( AUC ) 2.5 in divided-doses , both given on Days 1 and 8 every 21-day cycle for up to 6 cycles or until disease progression . | [
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] | Phase I/II trial of vinorelbine and divided-dose carboplatin in advanced non-small cell lung cancer. vinorelbine administered in a doublet with cisplatin has become a standard treatment in patients with advanced non-small cell lung cancer (NSCLC). However, carboplatin appears to provide comparable efficacy with a bette... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Phase I/II trial of vinorelbine and divided-dose carboplatin in advanced non-s... |
060a83e0337e3cebe9a672cf318d7346 | Dexamethasone exhibited the highest effect on paclitaxel anti-tumor activity , in a dose-dependent fashion . | [
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] | Efficacy of paclitaxel/dexamethasone intra-tumoral delivery in treating orthotopic mouse breast cancer. The effect of topical co-administration of promoter drugs with paclitaxel to increase anti-tumor effects of paclitaxel was investigated. Mice with orthotopic 4T1-Luc breast cancer received single intra-tumoral inject... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Efficacy of paclitaxel/dexamethasone intra-tumoral delivery in treating orthot... |
5b6f7ce634e82dcb2432c7f10ee0a2a7 | The first available studies demonstrate the value of these compounds with an improved prognosis of metastatic patients in combination with endocrine therapy ( palbociclib , ribociclib ) or in monotherapy ( abemaciclib ) . | [
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"sta... | [] | [Cell cycle inhibitors in endocrine receptor positive breast cancer]. Dysregulation of cellular cycle is a key component of carcinogenesis and its targeting represents an interesting approach. Recently, the development of selective inhibitors of the cycle targeting the cyclin-dependent kinases (CDK) 4 and 6 revived int... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
[Cell cycle inhibitors in endocrine receptor positive breast cancer]. Dysregul... |
01488860ce8a1f2064d637382e61dcc7 | Flunarizine pretreatment abolished the augmented behavioral response to repeated cocaine administration while diltiazem was less effective . | [
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] | [] | Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockers. Recent studies suggest that calcium influx via L-type calcium channels is necessary for psychostimulant-induced behavioral sensitization. In addition, chronic a... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Augmented behavioral response and enhanced synaptosomal calcium transport indu... |
7c380c02bd3fbd1115606724ac821b1c | We therefore explored the in vitro combination of amphotericin B with itraconazole against 14 clinical Aspergillus fumigatus isolates ( 9 itraconazole susceptible and 5 itraconazole resistant ) with a colorimetric broth microdilution checkerboard technique using two drug interaction models able to explore complicated p... | [
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] | The concentration-dependent nature of in vitro amphotericin B-itraconazole interaction against Aspergillus fumigatus: isobolographic and response surface analysis of complex pharmacodynamic interactions. The interaction between polyenes and azoles is not well understood. We therefore explored the in vitro combination o... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
The concentration-dependent nature of in vitro amphotericin B-itraconazole int... |
629f2afd9f04075555356b672f8630aa | This study evaluated the safety and efficacy of inotuzumab ozogamicin ( INO ) , a targeted humanized anti-CD22 antibody conjugated to calicheamicin , plus rituximab ( R-INO ) every 3 weeks , up to six cycles , followed by high dose therapy and autologous stem cell transplant ( HDT-aSCT ) in patients with high-risk rela... | [
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... | [
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] | A phase 2 study of inotuzumab ozogamicin and rituximab, followed by autologous stem cell transplant in patients with relapsed/refractory diffuse large B-cell lymphoma. This study evaluated the safety and efficacy of inotuzumab ozogamicin ( INO ) , a targeted humanized anti-CD22 antibody conjugated to calicheamicin , p... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A phase 2 study of inotuzumab ozogamicin and rituximab, followed by autologous... |
cc696918283e488232e6e3aa8ef89b9e | These are the first 2 reports of successful treatment of this condition by use of a combination of methylprednisolone and mycophenolate mofetil , and , in 1 of the cases , additional medication with intravenous immunoglobulin . | [
{
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{
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{
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] | Severe Ocular Myositis After Ipilimumab Treatment for Melanoma: A Report of 2 Cases. ipilimumab binds and blocks cytotoxic T-lymphocyte-associated antigen-4, causing enhanced T-cell reaction, antitumor response, and significant improvement of the overall survival of patients with metastatic melanoma. Patients treated w... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Severe Ocular Myositis After Ipilimumab Treatment for Melanoma: A Report of 2 ... |
258df1cdd27778c584adcdc22e0d0eb5 | The introduction of the selective serotonin reuptake inhibitors , moclobemide and mianserin has been a major advance in the treatment of depression , and is already leading to major shifts in the pattern of antidepressants prescribing . | [
{
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{
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] | [] | The management of depression. The place of the new antidepressants. Part 1. General overview. The introduction of the selective serotonin reuptake inhibitors , moclobemide and mianserin has been a major advance in the treatment of depression , and is already leading to major shifts in the pattern of antidepressants pr... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
The management of depression. The place of the new antidepressants. Part 1. Ge... |
44576795e1d4a224dc2c88ac25c408d3 | Four of these had equivocal plasma levels of both norepinephrine and epinephrine , suggesting that overnight clonidine suppression may be of particular value when tumor secretion is intermittent or low . | [
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] | [] | Overnight clonidine suppression test in the diagnosis and exclusion of pheochromocytoma. In a prospective study designed to differentiate pheochromocytoma from other forms of hypertension, urinary catecholamines were measured after sleep and clonidine administration in 12 patients with pheochromocytoma, 19 hypertensive... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Overnight clonidine suppression test in the diagnosis and exclusion of pheochr... |
f112ca056732ab95e87bed0eac7b0a3e | In conclusion , concurrent introduction of ATGAM and tacrolimus is a promising therapeutic combination for GVHD refractory to steroids and cyclosporine . | [
{
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{
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] | Combination therapy with tacrolimus and anti-thymocyte globulin for the treatment of steroid-resistant acute graft-versus-host disease developing during cyclosporine prophylaxis. We report our experience with the combination of anti-thymocyte globulin (ATGAM) and tacrolimus in the treatment of 20 patients with steroid ... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Combination therapy with tacrolimus and anti-thymocyte globulin for the treatm... |
2bdca5594e92c0fa8209ac4727e17d4d | Comparison of geometric least-squares mean PK parameters between arms showed no impact of pertuzumab on the PK of trastuzumab or docetaxel . | [
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] | Absence of pharmacokinetic drug-drug interaction of pertuzumab with trastuzumab and docetaxel. pertuzumab is a novel antihuman epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody. Combined with trastuzumab plus docetaxel, pertuzumab improved progression-free and overall survival versus trastuzumab p... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Absence of pharmacokinetic drug-drug interaction of pertuzumab with trastuzuma... |
bebf5e7b7aae549b7a98aa08fe3a6e12 | This study was designed to test the hypothesis that positively charged dendrimers form a complex with enoxaparin , a low-molecular weight heparin ( LMWH ) , and that the resulting drug-dendrimer complex is effective in preventing deep vein thrombosis after pulmonary administration . | [
{
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{
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] | [] | Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular weight heparin. This study was designed to test the hypothesis that positively charged dendrimers form a complex with enoxaparin , a low-molecular weight heparin ( LMWH ) , and that the resulting drug-dendrimer complex is effective in preven... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low-molecular ... |
768337984609fbfa1979e5a454e65f0d | We proved experimentally the use of ECEEM for multiplex determination of kinetic parameters describing weak ( 3 mM > K(d ) > 80 μM ) and fast ( 0.25 s ≥ τ ≥ 0.9 ms ) noncovalent interactions between four small molecule drugs ( ibuprofen , S-flurbiprofen , salicylic acid and phenylbutazone ) and α- and β-cyclodextrins . | [
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{
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{
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"text": "salicylic acid",
... | [
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{
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] | Revealing equilibrium and rate constants of weak and fast noncovalent interactions. Rate and equilibrium constants of weak noncovalent molecular interactions are extremely difficult to measure. Here, we introduced a homogeneous approach called equilibrium capillary electrophoresis of equilibrium mixtures (ECEEM) to det... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Revealing equilibrium and rate constants of weak and fast noncovalent interact... |
daefc547a89f7ce7f0dc7b13ae5937ef | We evaluated the stem cell mobilization regimen of high-dose ifosfamide plus etoposide in 32 patients with epithelial ovarian cancer , who had a positive second-look laparatomy or recurrent disease . | [
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] | High-dose ifosfamide and etoposide with filgrastim for stem cell mobilization in patients with advanced ovarian cancer. High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation has shown promise as treatment for recurrent or persistent epithelial ovarian cancer. We evaluated the stem c... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
High-dose ifosfamide and etoposide with filgrastim for stem cell mobilization ... |
1363fe5e83c9f5c523828ec013b8a56b | Esomeprazole , a proton-pump inhibitor ( PPI ) , is the S-isomer of omeprazole . | [
{
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] | [] | Esomeprazole: a clinical review. The pharmacology, pharmacodynamics, pharmacokinetics, clinical efficacy, and adverse effects of esomeprazole are reviewed. Esomeprazole , a proton-pump inhibitor ( PPI ) , is the S-isomer of omeprazole . esomeprazole has FDA-approved labeling for use in the treatment of symptomatic gast... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Esomeprazole: a clinical review. The pharmacology, pharmacodynamics, pharmacok... |
34085f618946f6f3b105553ee700b4ba | This increase in the number of vasopressin and oxytocin containing neurons in the pig hypothalamus is much later in development than has ever been reported so far . | [
{
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] | [] | A vasopressin and oxytocin containing nucleus in the pig hypothalamus that shows neuronal changes during puberty. A vasopressin and oxytocin containing nucleus is described for the first time in the pig hypothalamus. It is located near the third ventricle, just dorsal to the suprachiasmatic nucleus, and consists of mag... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A vasopressin and oxytocin containing nucleus in the pig hypothalamus that sho... |
4d1c93db896cd77cb92357c8cd08b272 | Combinations of alkylating agents and fludarabine or cladribine are also synergistic in producing significantly enhanced activity against refractory lymphoid malignancies , but at the cost of increased haematological toxicity . | [
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] | Clinical pharmacokinetics of nucleoside analogues: focus on haematological malignancies. This review establishes the pharmacokinetic characteristics of the major nucleoside analogues with cytotoxic activity. cytarabine, pentostatin, fludarabine, cladribine and gemcitabine are all prodrugs whose plasma pharmacokinetics ... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Clinical pharmacokinetics of nucleoside analogues: focus on haematological mal... |
44961781380ebcb4e76b2474630bdd4c | The pharmacodynamic effects of single doses of trazodone ( 100 mg ) , amitriptyline ( 50 mg ) or placebo either alone or with ethanol ( 0.5 ml/kg ) were investigated in 6 healthy volunteers in a double-blind crossover study . | [
{
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] | Evaluation of possible interactions between ethanol and trazodone or amitriptyline. The pharmacodynamic effects of single doses of trazodone ( 100 mg ) , amitriptyline ( 50 mg ) or placebo either alone or with ethanol ( 0.5 ml/kg ) were investigated in 6 healthy volunteers in a double-blind crossover study . Plasma co... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Evaluation of possible interactions between ethanol and trazodone or amitripty... |
f6d6d6d6c7e5d3b223469c4647ae830c | A 70-year-old Asian man was diagnosed with PVT two months after initiating 5-fluorouracil/leucovorin , irinotecan , and bevacizumab therapy for rectal cancer with liver metastases . | [
{
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{
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"text": "bevacizum... | [
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] | Portal Vein Thrombosis in Metastatic Colorectal Cancer During FOLFIRI-bevacizumab Chemotherapy Successfully Treated with Apixaban. Portal vein thrombosis (PVT) while using an angiogenesis inhibitor is relatively rare. A 70-year-old Asian man was diagnosed with PVT two months after initiating 5-fluorouracil/leucovorin ,... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Portal Vein Thrombosis in Metastatic Colorectal Cancer During FOLFIRI-bevacizu... |
cb78de3312276734322bda401ae26214 | Results of cell viability assays revealed that treatment with a combination of imatinib and chemotherapy agents irinotecan or 5‑Fu synergistically inhibited cell growth , compared with treatment with any of these drugs alone . | [
{
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{
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... | [
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] | Imatinib‑induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress. imatinib is a powerful tyrosine kinase inhibitor that specifically targets BCR‑ABL, c‑KIT, and PDGFR kinases, and is used in the treatment of chronic myelogenous leukemia, gastrointestinal stromal tumors, and other types of ... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Imatinib‑induced apoptosis of gastric cancer cells is mediated by endoplasmic ... |
1f7554912aff5c289e111df0ba0da420 | We concluded that ifosfamide is an active agent even in patients with tumours resistant to cyclophosphamide . | [
{
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}
] | [] | Ifosfamide in the treatment of high-grade recurrent non-Hodgkin's lymphomas. We report the results of two phase II trials of ifosfamide in very high risk patients with either partially responsive or recurrent non-Hodgkin's lymphomas. In the first study, in which patients were extremely heavily pretreated (50 per cent h... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Ifosfamide in the treatment of high-grade recurrent non-Hodgkin's lymphomas. W... |
38dba7074fb0f572a099da86370fab35 | The combination of a fluoropyrimidine ( 5-fluorouracil or capecitabine ) with either oxaliplatin or irinotecan has been widely accepted as standard cytotoxic chemotherapy for either the first- or second-line treatment of mCRC . | [
{
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},
{
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"text": "irinotecan",
"star... | [
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{
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] | Options for Second-Line Treatment in Metastatic Colorectal Cancer. Colorectal cancer (CRC) remains a major public health problem in the United States and worldwide. The majority of patients who have CRC eventually present with metastatic disease. The overall therapeutic goals for most patients with metastatic CRC (mCRC... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Options for Second-Line Treatment in Metastatic Colorectal Cancer. Colorectal ... |
26176aad604a52fd2bb4bcc904127ead | In 1517 poor prognosis patients , 21 regimens were used , the commonest being CAV , EV ( etoposide , vincristine ) , CbE , CAV alternating with PE , and oral etoposide . | [
{
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{
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{
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"text": "etoposide",
"start": ... | [] | A national survey of the chemotherapy regimens used to treat small cell lung cancer (SCLC) in the United Kingdom. Many chemotherapy regimens are used for treating SCLC in the United Kingdom, but it is not known, in any detail, which regimens are used, by which specialists, for which types of patient. We conducted a sur... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A national survey of the chemotherapy regimens used to treat small cell lung c... |
c87bef0baeedd5907639f42835450242 | Utilizing this data , we suggest that nivolumab plus ipilimumab and cabozantinib may be favored for first-line treatment of specific populations of older patients . | [
{
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{
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{
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"text": "cabozantinib",
"start": 68,... | [
{
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] | Treatment Decisions for Metastatic Clear Cell Renal Cell Carcinoma in Older Patients: The Role of TKIs and Immune Checkpoint Inhibitors. Given the underrepresentation of older patients in registration trials for metastatic renal cell carcinoma (mRCC), data to support the use of any particular systemic therapy over othe... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Treatment Decisions for Metastatic Clear Cell Renal Cell Carcinoma in Older Pa... |
2086edd2e2d105c3fd82dcf2747792c3 | The aim of this study was to evaluate all E. coli positive blood cultures collected during a 4-y period in a haematological department using piperacillin plus netilmicin for empiric treatment of febrile episodes . | [
{
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},
{
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] | [
{
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] | Piperacillin-resistant Escherichia coli bacteraemia: relation to empiric therapy and clinical outcome. Escherichia coli is a leading cause of bacteraemia. The aim of this study was to evaluate all E. coli positive blood cultures collected during a 4-y period in a haematological department using piperacillin plus netilm... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Piperacillin-resistant Escherichia coli bacteraemia: relation to empiric thera... |
d86c5461771613501c2aa3b8c0ef2d53 | Thirty-five percent ( 6 of 17 ) of the patients receiving docetaxel alone and 53 % ( 19 of 36 ) of those receiving docetaxel and thalidomide have had a PSA decrease of at least 50 % . | [
{
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"text": "docetaxel",
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"token_start": 11,
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},
{
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},
{
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"text": "thalidomide",
"start": ... | [
{
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"is_context_needed": true
}
] | A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer. New therapeutic alternatives are needed to improve outcomes in patients with androgen-independent prostate cancer (AIPC). For several years, researchers at the National Cancer Institute have been interested in ... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androg... |
eab1f4116fcece11689b6ced429d2980 | Evidence-based guidelines recommend nicotine replacement therapy , bupropion SR , and varenicline as effective alternatives for smoking cessation therapy , especially when combined with behavioral interventions . | [
{
"span_id": 0,
"text": "nicotine",
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{
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"token_start": 7,
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},
{
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"text": "varenicline",
"start": 86,
... | [] | Smoking cessation intervention: an evidence-based approach. Cigarette smoking represents the most important source of preventable morbidity and premature mortality worldwide. Approximately 100 million deaths were caused by tobacco use in the 20th century. There are >1 billion smokers worldwide, and globally the use of ... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Smoking cessation intervention: an evidence-based approach. Cigarette smoking ... |
7a45554d0d2040d636c725b31394506f | The efficacy of methotrexate ( MTX ) as a single graft-versus-host disease ( GVHD ) prophylaxis agent was compared to that of cyclosporin A ( CSA ) in 62 pediatric patients ( median age : 8 years ) with hematological malignancies who had undergone bone marrow transplantation ( BMT ) from HLA-identical sibling donors at... | [
{
"span_id": 0,
"text": "methotrexate",
"start": 16,
"end": 28,
"token_start": 3,
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},
{
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"text": "cyclosporin",
"start": 126,
"end": 137,
"token_start": 22,
"token_end": 23
}
] | [] | Methotrexate vs Cyclosporin A as a single agent for graft-versus-host disease prophylaxis in pediatric patients with hematological malignancies undergoing allogeneic bone marrow transplantation from HLA-identical siblings: a single-center analysis in Japan. The efficacy of methotrexate ( MTX ) as a single graft-versus... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Methotrexate vs Cyclosporin A as a single agent for graft-versus-host disease ... |
6aa32e480cf9ee6187d23672321fb66f | Owing to the wide spread activation of this pathway in numerous neoplasms , trametinib and cobimetinib are being studied in combination with other targeted and cytotoxic drugs in a variety of clinical situations . | [
{
"span_id": 0,
"text": "trametinib",
"start": 76,
"end": 86,
"token_start": 13,
"token_end": 14
},
{
"span_id": 1,
"text": "cobimetinib",
"start": 91,
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"token_start": 15,
"token_end": 16
}
] | [] | Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treatment of cutaneous melanomas. The Ras-Raf-MEK-ERK (Map kinase) cellular pathway is a highly conserved eukaryotic signaling module that transduces extracellular signals from growth factors and cytokines into intracellular regulatory events that... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treat... |
1f40155876a82805baff26c32ebc9de0 | All these isolates were found to survive in presence of heavy metals like cadmium , lead and zinc and were resistant to antibiotics like ampicillin , tetracycline , streptomycin , penicillin and chloramphenicol as indicated by their Minimum Inhibitory Concentrations ( MIC ) . | [
{
"span_id": 0,
"text": "ampicillin",
"start": 137,
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"token_start": 24,
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},
{
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"text": "tetracycline",
"start": 150,
"end": 162,
"token_start": 26,
"token_end": 27
},
{
"span_id": 2,
"text": "streptomycin",
"s... | [] | Identification and Characterization of the microbial communities found in electronic industrial effluent and their potential for bioremediation. Microbial communities are dynamic systems that develop depending on the ecological niche in which they survive. Electronic industry effluent, rich in heavy metals and salts is... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Identification and Characterization of the microbial communities found in elec... |
51927614ff11b96d6d8c367030196710 | Reduction of ASS1 expression by siRNA significantly sensitized mesothelioma spheroids to the pro-apoptotic effects of bortezomib and of cisplatin plus pemetrexed . | [
{
"span_id": 0,
"text": "bortezomib",
"start": 118,
"end": 128,
"token_start": 15,
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},
{
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"text": "pemetrexed",
"start": 151,
"end": 161,
"token_start": 20,
"token_end": 21
},
{
"span_id": 2,
"text": "cisplatin",
"start"... | [
{
"class": "POS",
"spans": [
1,
2
],
"is_context_needed": false
}
] | Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma. To investigate the underlying causes of chemoresistance in malignant pleural mesothelioma, we have studied mesothelioma cell lines as 3D spheroids, which acquire increased chemoresistance compared to 2D monolayers. We asked... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS... |
76c1b10dff966a31783801aacb7c157e | In conclusion , the combination of thalidomide and cyclosporine in subtherapeutic doses may be useful for the treatment of skin allografts . | [
{
"span_id": 0,
"text": "thalidomide",
"start": 35,
"end": 46,
"token_start": 6,
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},
{
"span_id": 1,
"text": "cyclosporine",
"start": 51,
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"token_start": 8,
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}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Effects of thalidomide, cyclosporine, and diclofenac on skin allograft survival in rabbits. The present study evaluated the effects of thalidomide, cyclosporine, and diclofenac on skin allograft survival in 42 rabbits divided into the following groups (n = 6): group 1, autograft control; group 2, allograft control; gro... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Effects of thalidomide, cyclosporine, and diclofenac on skin allograft surviva... |
5697e211a87cb40532bd2a6c0209c3f6 | We now wish to report that , under these conditions , the pss-8 mutant is hypersensitive to certain antibiotics , especially to streptomycin , kanamycin , and gentamicin , although also to ampicillin and novobiocin . | [
{
"span_id": 0,
"text": "streptomycin",
"start": 128,
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},
{
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"text": "kanamycin",
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"token_start": 24,
"token_end": 25
},
{
"span_id": 2,
"text": "gentamicin",
"star... | [] | Envelope composition and antibiotic hypersensitivity of Escherichia coli mutants defective in phosphatidylserine synthetase. Mutants of Escherichia coli K12, defective in phosphatidylserine synthetase (pss), can be isolated as temperature-sensitive, conditional lethals. When cultivated at intermediate temperatures (30 ... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Envelope composition and antibiotic hypersensitivity of Escherichia coli mutan... |
cd6a412fcb3306448aa13a6679d7e767 | During the first 5 min of cooling , CVC decreased at control sites ( lactated Ringer solution ) to -45 + /- 6 % ( P < 0.001 ) , increased at adrenoceptor-antagonized sites ( yohimbine + propranolol ) to 15 + /- 14 % ( P = 0.002 ) , and remained unchanged at both Rho kinase-inhibited ( fasudil ) and adrenoceptor-antagon... | [
{
"span_id": 0,
"text": "yohimbine",
"start": 174,
"end": 183,
"token_start": 35,
"token_end": 36
},
{
"span_id": 1,
"text": "propranolol",
"start": 186,
"end": 197,
"token_start": 37,
"token_end": 38
},
{
"span_id": 2,
"text": "fasudil",
"start": ... | [] | Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin. Cutaneous vasoconstriction (VC) is the initial thermoregulatory response to cold exposure and can be elicited through either whole body or localized skin cooling. However, the mechanisms governing local cold-induced VC are not well... | null | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in h... |
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