doc_id stringlengths 32 32 | sentence stringlengths 47 584 | spans list | rels list | paragraph stringlengths 165 6.87k | source stringlengths 38 41 ⌀ | instruction stringlengths 506 7.18k |
|---|---|---|---|---|---|---|
85888116da06bb6c9a2ad7c9e1ea3c18 | The study objectives were to evaluate the safety , tolerability , and preliminary efficacy of multiple doses of dulanermin in combination with modified FOLFOX6 and bevacizumab in previously untreated patients with locally advanced , recurrent , or metastatic colorectal cancer . | [
{
"span_id": 0,
"text": "dulanermin",
"start": 112,
"end": 122,
"token_start": 18,
"token_end": 19
},
{
"span_id": 1,
"text": "FOLFOX6",
"start": 152,
"end": 159,
"token_start": 23,
"token_end": 24
},
{
"span_id": 2,
"text": "bevacizumab",
"start":... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | A phase 1B study of dulanermin in combination with modified FOLFOX6 plus bevacizumab in patients with metastatic colorectal cancer. The study objectives were to evaluate the safety , tolerability , and preliminary efficacy of multiple doses of dulanermin in combination with modified FOLFOX6 and bevacizumab in previous... | https://pubmed.ncbi.nlm.nih.gov/24075777/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A phase 1B study of dulanermin in combination with modified FOLFOX6 plus bevac... |
cdca7eda69e96a52d1fdd56e49cf9261 | Inhalatory beta2-mimetics with long-term action ( LABA ) , formoterol and salmeterol , possess a period of action longer than 12 hours . | [
{
"span_id": 0,
"text": "formoterol",
"start": 59,
"end": 69,
"token_start": 9,
"token_end": 10
},
{
"span_id": 1,
"text": "salmeterol",
"start": 74,
"end": 84,
"token_start": 11,
"token_end": 12
}
] | [] | [A comparison of inhalatory beta2-mimetics with long-term action (formoterol vs. salmeterol)]. Asthma is a serious global health problem. People of all age groups in all countries of the world suffer from this chronic disease of the respiratory tract, which may have a very serious and sometimes fatal course. Most beta2... | https://pubmed.ncbi.nlm.nih.gov/17128593/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
[A comparison of inhalatory beta2-mimetics with long-term action (formoterol v... |
82bcf2ff9f17f26be78f8edd00b37e44 | This study evaluates the possible protective effects of the calcium channel blocker amlodipine , the angiotensin converting enzyme inhibitor lisinopril , and the xanthine oxidase inhibitor allopurinol against experimental acetaminophen-induced hepatotoxicity , aiming to understand its underlying hepatotoxic mechanisms ... | [
{
"span_id": 0,
"text": "amlodipine",
"start": 84,
"end": 94,
"token_start": 12,
"token_end": 13
},
{
"span_id": 1,
"text": "lisinopril",
"start": 141,
"end": 151,
"token_start": 19,
"token_end": 20
},
{
"span_id": 2,
"text": "allopurinol",
"start"... | [] | Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats. Exposure to chemotherapeutic agents such as acetaminophen may lead to serious liver injury. Calcium deregulation, angiotensin II production and xanthine oxidase activity are suggested to play mechanistic roles in such inju... | https://pubmed.ncbi.nlm.nih.gov/27829805/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepa... |
ae3ea590e974f8fa2cf4dadd985b54a2 | The study was conducted in 90 patients operated on for unilateral breast cancer who were then assigned to receive either 12 intravenous cycles of cyclophosphamide , methotrexate and fluorouracil ( CMF ) every three weeks , or no further treatment . | [
{
"span_id": 0,
"text": "cyclophosphamide",
"start": 146,
"end": 162,
"token_start": 24,
"token_end": 25
},
{
"span_id": 1,
"text": "methotrexate",
"start": 165,
"end": 177,
"token_start": 26,
"token_end": 27
},
{
"span_id": 2,
"text": "fluorouracil",
... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | Adjuvant cyclophosphamide, methotrexate and fluorouracil in node-negative and estrogen receptor-negative breast cancer. Updated results. Node-negative breast cancers are considered to comprise a subgroup which is amenable to cure with local-regional therapy alone. However, approximately 30% of affected patients present... | https://pubmed.ncbi.nlm.nih.gov/8839902/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Adjuvant cyclophosphamide, methotrexate and fluorouracil in node-negative and ... |
28dd79429e758bc58daa73abfa6f418a | This study compared the efficacy of topical emedastine 0.05 % ophthalmic solution with that of oral loratadine 10 mg and their combination in the conjunctival allergen challenge model of allergic conjunctivitis . | [
{
"span_id": 0,
"text": "emedastine",
"start": 44,
"end": 54,
"token_start": 7,
"token_end": 8
},
{
"span_id": 1,
"text": "loratadine",
"start": 100,
"end": 110,
"token_start": 16,
"token_end": 17
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | A randomized, double-blind, placebo-controlled comparison of emedastine 0.05% ophthalmic solution with loratadine 10 mg and their combination in the human conjunctival allergen challenge model. When selecting treatment for allergic conjunctivitis, a primary concern is whether to choose local or systemic therapy. ### ob... | https://pubmed.ncbi.nlm.nih.gov/11952027/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A randomized, double-blind, placebo-controlled comparison of emedastine 0.05% ... |
0c769f1d92ebcf03959b819c250c55aa | Erythromycin , clindamycin and carbenicillin suppressed the donor flora permanently , as could be seen by the reduced colonization resistance . | [
{
"span_id": 0,
"text": "Erythromycin",
"start": 0,
"end": 12,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "clindamycin",
"start": 15,
"end": 26,
"token_start": 2,
"token_end": 3
},
{
"span_id": 2,
"text": "carbenicillin",
"start": ... | [] | Recontamination after gastrointestinal decontamination with non-absorbable antibiotics. In an attempt to restore the colonization resistance we administered anaerobic microflora to prevent an abnormal colonization of the intestine after antibiotic treatment had been discontinued. After the antibiotics had been disconti... | https://pubmed.ncbi.nlm.nih.gov/6795128/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Recontamination after gastrointestinal decontamination with non-absorbable ant... |
a44bb4123bef8777f41094293cb87a41 | Mycophenolate mofetil resulted in rapid improvement of steroid-refractory immune-related adverse event hepatitis , induced by nivolumab plus ipilimumab . | [
{
"span_id": 0,
"text": "Mycophenolate",
"start": 0,
"end": 13,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "nivolumab",
"start": 126,
"end": 135,
"token_start": 15,
"token_end": 16
},
{
"span_id": 2,
"text": "ipilimumab",
"start": ... | [
{
"class": "COMB",
"spans": [
1,
2
],
"is_context_needed": true
}
] | Successful mycophenolate mofetil treatment of a patient with severe steroid-refractory hepatitis evoked by nivolumab plus ipilimumab treatment for relapsed bladder cancer. Mycophenolate mofetil resulted in rapid improvement of steroid-refractory immune-related adverse event hepatitis , induced by nivolumab plus ipilim... | https://pubmed.ncbi.nlm.nih.gov/33598220/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Successful mycophenolate mofetil treatment of a patient with severe steroid-re... |
9a000d387e6e636fdacb29a6195a8626 | The mannose-linked prodrugs of saquinavir and indinavir display therefore a most promising therapeutic potential provided that bioavailability , penetration into the HIV infected macrophages , and HIV-reservoirs of these PIs are improved . | [
{
"span_id": 0,
"text": "saquinavir",
"start": 31,
"end": 41,
"token_start": 4,
"token_end": 5
},
{
"span_id": 1,
"text": "indinavir",
"start": 46,
"end": 55,
"token_start": 6,
"token_end": 7
}
] | [] | Synthesis and in vitro biological evaluation of mannose-containing prodrugs derived from clinically used HIV-protease inhibitors with improved transepithelial transport. In an approach to improve the pharmacological properties, safety and pharmacokinetic profiles, and their penetration into HIV reservoirs or sanctuarie... | https://pubmed.ncbi.nlm.nih.gov/17105238/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Synthesis and in vitro biological evaluation of mannose-containing prodrugs de... |
1082f766cc489eaa697664eb74af0378 | Resistant isolates emerged quickly and uniformly in all patients administered nevirapine either as monotherapy or in combination with zidovudine ( AZT ) . | [
{
"span_id": 0,
"text": "nevirapine",
"start": 78,
"end": 88,
"token_start": 10,
"token_end": 11
},
{
"span_id": 1,
"text": "zidovudine",
"start": 134,
"end": 144,
"token_start": 18,
"token_end": 19
}
] | [
{
"class": "COMB",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy. Drug susceptibility and mutations in the reverse transcriptase (RT) gene were analyzed with 167 virus isolates from 38 patients treated with nevirapine, a potent nonnucleoside inhibitor of human immunodeficiency virus type 1... | https://pubmed.ncbi.nlm.nih.gov/7509000/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Nevirapine resistance mutations of human immunodeficiency virus type 1 selecte... |
250d6ed126d0eaf8fc10454a26a19069 | Postoperative combination chemotherapy for six cycles with cisplatin ( 100 mg/m2 per day for 1 day every 3 weeks ) , bleomycin ( 15 units intravenously weekly for 18 weeks ) and etoposide ( 100 mg/m2 per day for 3 days every 3 weeks ) were given and the tumor responded dramatically . | [
{
"span_id": 0,
"text": "cisplatin",
"start": 59,
"end": 68,
"token_start": 7,
"token_end": 8
},
{
"span_id": 1,
"text": "bleomycin",
"start": 117,
"end": 126,
"token_start": 21,
"token_end": 22
},
{
"span_id": 2,
"text": "etoposide",
"start": 178,... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": false
}
] | Huge retroperitoneal germinoma presenting with pathological fracture of the spine. Primary retroperitoneal germ cell tumors are extremely rare neoplasms. The most common presenting features are abdominal pain and palpable abdominal masses. Pathological fractures of the spine presenting as bilateral lower leg weakness a... | https://pubmed.ncbi.nlm.nih.gov/12635842/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Huge retroperitoneal germinoma presenting with pathological fracture of the sp... |
9238a8d50acf022196b0df5ab094dc79 | The other received chemotherapy including prednisone , vincristine , cytarabine and L-asparaginase , combined with intrathecal injections of methotrexate , dexamethasone and Ara-C and supporting treatment . | [
{
"span_id": 0,
"text": "prednisone",
"start": 42,
"end": 52,
"token_start": 5,
"token_end": 6
},
{
"span_id": 1,
"text": "vincristine",
"start": 55,
"end": 66,
"token_start": 7,
"token_end": 8
},
{
"span_id": 2,
"text": "cytarabine",
"start": 69,
... | [
{
"class": "POS",
"spans": [
0,
1,
2,
3
],
"is_context_needed": true
}
] | [Renal tubular acidosis as an initial manifestation in children with malignant lymphoma]. Primary renal lymphoma is one of the malignant lymphomas that initially presents in the extra lymphonode, which is rarely seen in children. This study reported two cases of primary renal lymphoma in children who were definitively ... | https://pubmed.ncbi.nlm.nih.gov/18706173/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
[Renal tubular acidosis as an initial manifestation in children with malignant... |
6ed6398f293569b074c6a6cdf21d3160 | Then , neoadjuvant chemotherapy ( NAC ) consisting of a combination of 5-fluorouracil ( 5-FU ) , oxaliplatin , irinotecan , and leucovorin ( FOLFOXIRI ) was planned , followed by primary tumor resection . | [
{
"span_id": 0,
"text": "5-fluorouracil",
"start": 71,
"end": 85,
"token_start": 12,
"token_end": 13
},
{
"span_id": 1,
"text": "oxaliplatin",
"start": 97,
"end": 108,
"token_start": 17,
"token_end": 18
},
{
"span_id": 2,
"text": "irinotecan",
"sta... | [
{
"class": "POS",
"spans": [
0,
1,
2,
3
],
"is_context_needed": true
}
] | A pathological complete response after neoadjuvant triplet chemotherapy for locally advanced transverse colon cancer. Perioperative chemotherapy could improve oncological outcomes for patients with advanced colon cancer. However, the effectiveness of triplet chemotherapy in the neoadjuvant setting is still unknown. ###... | https://pubmed.ncbi.nlm.nih.gov/32535526/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A pathological complete response after neoadjuvant triplet chemotherapy for lo... |
893a4fe9446abfbc8679233b84a42857 | Interestingly , aspirin not only significantly inhibited the growth of TNBC cells , but also attenuated YAP and β-catenin expression by upregulating the E3 ubiquitin ligase β-TrCP to abolished docetaxel and vinorelbine resistance . | [
{
"span_id": 0,
"text": "aspirin",
"start": 16,
"end": 23,
"token_start": 2,
"token_end": 3
},
{
"span_id": 1,
"text": "docetaxel",
"start": 193,
"end": 202,
"token_start": 29,
"token_end": 30
},
{
"span_id": 2,
"text": "vinorelbine",
"start": 207,... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": false
}
] | Aspirin attenuates YAP and β-catenin expression by promoting β-TrCP to overcome docetaxel and vinorelbine resistance in triple-negative breast cancer. The use of aspirin has been associated with reduced breast cancer risk, but it is litter known if aspirin overcomes chemoresistance in triple-negative breast cancer (TNB... | https://pubmed.ncbi.nlm.nih.gov/32661222/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Aspirin attenuates YAP and β-catenin expression by promoting β-TrCP to overcom... |
933527b89d2e939d859d3827c6181476 | No alterations in paclitaxel or doxorubicin pharmacokinetics were observed when the drugs were administered alone versus in combination . | [
{
"span_id": 0,
"text": "paclitaxel",
"start": 18,
"end": 28,
"token_start": 3,
"token_end": 4
},
{
"span_id": 1,
"text": "doxorubicin",
"start": 32,
"end": 43,
"token_start": 5,
"token_end": 6
}
] | [
{
"class": "COMB",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Combination paclitaxel (Taxol) and doxorubicin therapy for metastatic breast cancer. paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) is a very active agent for the treatment of breast cancer, with associated complete response rates of 12% in patients with minimally pretreated metastatic disease. Simulta... | https://pubmed.ncbi.nlm.nih.gov/7939757/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Combination paclitaxel (Taxol) and doxorubicin therapy for metastatic breast c... |
24dcd3973e994e04cedf76aea5968ffc | Twenty-seven received rituximab mainly in addition to high-dose cytarabine and etoposide ( n = 18 ) and/or ifosfamide , carboplatin , and etoposide ( n = 7 ) . | [
{
"span_id": 0,
"text": "rituximab",
"start": 22,
"end": 31,
"token_start": 2,
"token_end": 3
},
{
"span_id": 1,
"text": "cytarabine",
"start": 64,
"end": 74,
"token_start": 8,
"token_end": 9
},
{
"span_id": 2,
"text": "etoposide",
"start": 79,
... | [
{
"class": "COMB",
"spans": [
0,
1,
2,
3,
4,
5
],
"is_context_needed": true
}
] | Outcome of relapse in children and adolescents with B-cell non-Hodgkin lymphoma and mature acute leukemia: A report from the French LMB study. In order to describe relapsed B-cell non-Hodgkin lymphoma and mature acute leukemia in children/adolescents treated with the Lymphomes Malins B (LMB) regimen and their outcome i... | https://pubmed.ncbi.nlm.nih.gov/31207026/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Outcome of relapse in children and adolescents with B-cell non-Hodgkin lymphom... |
d1b822405fac9b02cb1858fa96693979 | A significant reduction in plasma 8-isoprostane and oxLDL levels was observed in all treatment groups [ by 10 % , 8 % and 6 % ( p < 0.05 compared with baseline ) and 41 % , 40 % and 39 % ( p < 0.001 compared with baseline ) in simvastatin , simvastatin/ezetimibe and rosuvastatin groups , respectively ] . | [
{
"span_id": 0,
"text": "simvastatin",
"start": 227,
"end": 238,
"token_start": 51,
"token_end": 52
},
{
"span_id": 1,
"text": "rosuvastatin",
"start": 267,
"end": 279,
"token_start": 55,
"token_end": 56
}
] | [] | Comparison of the effect of simvastatin versus simvastatin/ezetimibe versus rosuvastatin on markers of inflammation and oxidative stress in subjects with hypercholesterolemia. Statins may exhibit anti-inflammatory and antioxidant effects. Whether different statins at equivalent doses or the combination of low-dose stat... | https://pubmed.ncbi.nlm.nih.gov/24125402/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Comparison of the effect of simvastatin versus simvastatin/ezetimibe versus ro... |
780f78a0170826430ef2034760acb82d | Both mono and combination therapies achieved the primary efficacy parameters : lowered diastolic blood pressure ( at trough ) more than placebo , p < 01 ( except the 120 mg verapamil SR , NS , 0.5 mg trandolapril , 0.5/180 and 2/120 combinations , p < 05 ) , yielded a trough to peak ratio of > 0.52 and had higher perce... | [
{
"span_id": 0,
"text": "verapamil",
"start": 173,
"end": 182,
"token_start": 31,
"token_end": 32
},
{
"span_id": 1,
"text": "trandolapril",
"start": 200,
"end": 212,
"token_start": 38,
"token_end": 39
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Efficacy of combination therapy with trandolapril and verapamil sr in primary hypertension: a 4 x 4 trial design. The Trandolapril Study Group. The Joint National Committee V suggested that combination therapy can provide effective blood pressure control in patients with stage I-IV hypertension. This 4 x 4 factorial tr... | https://pubmed.ncbi.nlm.nih.gov/9107443/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Efficacy of combination therapy with trandolapril and verapamil sr in primary ... |
2b6693d5c27ba14a8015f09d746854cd | In metastastic patients , the combination of gemcitabine and cisplatin has become the new standard regimen due to a lower toxicity in comparison to the combination of methotrexate , vinblastine , doxorubicin , and cisplatin ( MVAC ) . | [
{
"span_id": 0,
"text": "gemcitabine",
"start": 45,
"end": 56,
"token_start": 7,
"token_end": 8
},
{
"span_id": 1,
"text": "methotrexate",
"start": 167,
"end": 179,
"token_start": 27,
"token_end": 28
},
{
"span_id": 2,
"text": "vinblastine",
"start... | [
{
"class": "POS",
"spans": [
0,
4
],
"is_context_needed": false
},
{
"class": "COMB",
"spans": [
1,
2,
3
],
"is_context_needed": true
}
] | [Neoadjuvant or Adjuvant Chemotherapy for Bladder Cancer?]. Advanced urothelial carcinoma of the bladder is associated with a high metastatic potential. Life expectancy for metastatic patients is poor and rarely exceeds more than one year without further therapy. Neoadjuvant chemotherapy can decrease the tumour burden ... | https://pubmed.ncbi.nlm.nih.gov/26077309/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
[Neoadjuvant or Adjuvant Chemotherapy for Bladder Cancer?]. Advanced urothelia... |
d5d8fcd01d8db1d9d3739da1219f562a | In the last few years , a flurry of new and more potent ALK inhibitors has emerged for the treatment of ALK-positive NSCLC , including ceritinib ( LDK378 ) , alectinib ( RO5424802/CH5424802 ) , AP26113 , ASP3026 , TSR-011 , PF-06463922 , RXDX-101 , X-396 , and CEP-37440 . | [
{
"span_id": 0,
"text": "ceritinib",
"start": 135,
"end": 144,
"token_start": 25,
"token_end": 26
},
{
"span_id": 1,
"text": "alectinib",
"start": 158,
"end": 167,
"token_start": 30,
"token_end": 31
}
] | [] | ALK inhibitors in non-small cell lung cancer: crizotinib and beyond. The treatment of patients with advanced non-small cell lung cancer (NSCLC) harboring chromosomal rearrangements of anaplastic lymphoma kinase (ALK) has been revolutionized by the development of crizotinib, a small molecule inhibitor of the tyrosine ki... | https://pubmed.ncbi.nlm.nih.gov/25322323/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
ALK inhibitors in non-small cell lung cancer: crizotinib and beyond. The treat... |
b5a06ce3b2c6a8e918a9ac3c2ff81e10 | A randomized clinical trial of adjuvant chemotherapy with doxorubicin , ifosfamide , and cisplatin followed by radiotherapy versus radiotherapy alone in patients with localized uterine sarcomas ( SARCGYN study ) . | [
{
"span_id": 0,
"text": "doxorubicin",
"start": 58,
"end": 69,
"token_start": 8,
"token_end": 9
},
{
"span_id": 1,
"text": "ifosfamide",
"start": 72,
"end": 82,
"token_start": 10,
"token_end": 11
},
{
"span_id": 2,
"text": "cisplatin",
"start": 89,... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | A randomized clinical trial of adjuvant chemotherapy with doxorubicin , ifosfamide , and cisplatin followed by radiotherapy versus radiotherapy alone in patients with localized uterine sarcomas ( SARCGYN study ) . There is no proven benefit of adjuvant treatment of uterine sarcoma (US). SARCGYN phase III study compared... | https://pubmed.ncbi.nlm.nih.gov/23139262/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A randomized clinical trial of adjuvant chemotherapy with doxorubicin , ifosfa... |
3af3c8177f3067d578e6e60e026f8a52 | Combination therapy with irinotecan ( CPT-11 ) , 5-fluorouracil ( 5-FU ) and leucovorin is widely used for the treatment of metastatic colorectal cancer . | [
{
"span_id": 0,
"text": "irinotecan",
"start": 25,
"end": 35,
"token_start": 3,
"token_end": 4
},
{
"span_id": 1,
"text": "leucovorin",
"start": 77,
"end": 87,
"token_start": 13,
"token_end": 14
},
{
"span_id": 2,
"text": "5-fluorouracil",
"start":... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | Pharmacodynamic study of the Saltz regimen for metastatic colorectal cancer in a hemodialyzed patient. Combination therapy with irinotecan ( CPT-11 ) , 5-fluorouracil ( 5-FU ) and leucovorin is widely used for the treatment of metastatic colorectal cancer . However, little is known about the safety of chemotherapy of ... | https://pubmed.ncbi.nlm.nih.gov/17952001/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Pharmacodynamic study of the Saltz regimen for metastatic colorectal cancer in... |
0b47114f991a5b292f543492d5a64fad | Long-term safety and outcome of fludarabine , cyclophosphamide and mitoxantrone ( FCM ) regimen in previously untreated patients with advanced follicular lymphoma : 12 years follow-up of a phase 2 trial . | [
{
"span_id": 0,
"text": "fludarabine",
"start": 32,
"end": 43,
"token_start": 5,
"token_end": 6
},
{
"span_id": 1,
"text": "cyclophosphamide",
"start": 46,
"end": 62,
"token_start": 7,
"token_end": 8
},
{
"span_id": 2,
"text": "mitoxantrone",
"star... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | Long-term safety and outcome of fludarabine , cyclophosphamide and mitoxantrone ( FCM ) regimen in previously untreated patients with advanced follicular lymphoma : 12 years follow-up of a phase 2 trial . fludarabine combinations are very affective in follicular lymphoma (FL) with high rates of complete response and pr... | https://pubmed.ncbi.nlm.nih.gov/28101592/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Long-term safety and outcome of fludarabine , cyclophosphamide and mitoxantron... |
faf925d887ed6a4e48d9695fbf094b0e | After clinical improvement under vemurafenib monotherapy , four cycles of ipilimumab were additionally administered . | [
{
"span_id": 0,
"text": "vemurafenib",
"start": 33,
"end": 44,
"token_start": 4,
"token_end": 5
},
{
"span_id": 1,
"text": "ipilimumab",
"start": 74,
"end": 84,
"token_start": 10,
"token_end": 11
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | 18F-FDG PET/CT longitudinal studies in patients with advanced metastatic melanoma for response evaluation of combination treatment with vemurafenib and ipilimumab. Sixteen BRAF-mutation positive, metastatic melanoma patients with highly advanced disease received combination therapy of vemurafenib and ipilimumab as an i... | https://pubmed.ncbi.nlm.nih.gov/30653029/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
18F-FDG PET/CT longitudinal studies in patients with advanced metastatic melan... |
2280600696c1c1d4dfb49c7feb372ecd | Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer ( TURANDOT ): primary endpoint results of a randomised , open-label , non-inferiority , phase 3 trial . | [
{
"span_id": 0,
"text": "Bevacizumab",
"start": 0,
"end": 11,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "paclitaxel",
"start": 17,
"end": 27,
"token_start": 2,
"token_end": 3
},
{
"span_id": 2,
"text": "bevacizumab",
"start": 35,
... | [
{
"class": "POS",
"spans": [
2,
3
],
"is_context_needed": true
},
{
"class": "COMB",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer ( TURANDOT ): primary endpoint results of a randomised , open-label , non-inferiority , phase 3 trial . The randomised phase 3 TURANDOT trial compared two approved bevacizumab-containing r... | https://pubmed.ncbi.nlm.nih.gov/27501767/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line... |
bd92e7ffac8bd34d9b66848f322ec216 | She underwent rectectomy and adjuvant chemotherapy with fluorouracil , leucovorin plus oxaliplatin for stage IIIB rectal cancer . | [
{
"span_id": 0,
"text": "fluorouracil",
"start": 56,
"end": 68,
"token_start": 7,
"token_end": 8
},
{
"span_id": 1,
"text": "leucovorin",
"start": 71,
"end": 81,
"token_start": 9,
"token_end": 10
},
{
"span_id": 2,
"text": "oxaliplatin",
"start": 8... | [
{
"class": "COMB",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | Esophageal Metastasis from Rectal Cancer Successfully Treated with Fluorouracil-Based Chemotherapy with Bevacizumab: A Case Report and Review of the Literature. Esophageal metastasis from colorectal carcinoma is uncommon, and diagnosis of esophageal metastasis is difficult. We report a case of a 54-year-old woman with ... | https://pubmed.ncbi.nlm.nih.gov/28626398/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Esophageal Metastasis from Rectal Cancer Successfully Treated with Fluorouraci... |
b3a8d61ce1a9282b5cf5c5a4d0f54a18 | We designed this phase II trial to evaluate the safety , tolerability , and efficacy of the combination of carboplatin , paclitaxel , cetuximab , and bevacizumab in chemotherapy-naive patients with advanced , nonsquamous NSCLC . | [
{
"span_id": 0,
"text": "carboplatin",
"start": 107,
"end": 118,
"token_start": 19,
"token_end": 20
},
{
"span_id": 1,
"text": "paclitaxel",
"start": 121,
"end": 131,
"token_start": 21,
"token_end": 22
},
{
"span_id": 2,
"text": "cetuximab",
"start... | [
{
"class": "POS",
"spans": [
0,
1,
2,
3
],
"is_context_needed": true
}
] | Phase II trial of carboplatin, paclitaxel, cetuximab, and bevacizumab followed by cetuximab and bevacizumab in advanced nonsquamous non-small-cell lung cancer: SWOG S0536. cetuximab and bevacizumab have each been demonstrated to prolong survival when added to chemotherapy in patients with advanced non-small-cell lung c... | https://pubmed.ncbi.nlm.nih.gov/24189513/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Phase II trial of carboplatin, paclitaxel, cetuximab, and bevacizumab followed... |
5f47b0d8abbede477b693d64fb8dd329 | All patients underwent mexiletine monotherapy ( M-mono ) , propafenone monotherapy ( P-mono ) , low dose combination therapy ( low M+P ) , and full dose combination therapy ( full M+P ) . | [
{
"span_id": 0,
"text": "mexiletine",
"start": 23,
"end": 33,
"token_start": 3,
"token_end": 4
},
{
"span_id": 1,
"text": "propafenone",
"start": 59,
"end": 70,
"token_start": 9,
"token_end": 10
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Mexiletine and propafenone: a comparative study of monotherapy, low, and full dose combination therapy. The electrophysiological effects of combination therapy of mexiletine and propafenone were assessed using standard 12-lead electrocardiogram (standard ECG), signal-averaged ECG (SAECG), and ambulatory ECG in 31 patie... | https://pubmed.ncbi.nlm.nih.gov/1279613/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Mexiletine and propafenone: a comparative study of monotherapy, low, and full ... |
d531c7b35a8bc9c67dad085ae9b7d352 | Cephalexin , 500 mg 4 times daily , plus trimethoprim-sulfamethoxazole , 320 mg/1600 mg twice daily , for 7 days ( n = 248 participants ) or cephalexin plus placebo for 7 days ( n = 248 participants ) . | [
{
"span_id": 0,
"text": "Cephalexin",
"start": 0,
"end": 10,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "cephalexin",
"start": 141,
"end": 151,
"token_start": 27,
"token_end": 28
},
{
"span_id": 2,
"text": "trimethoprim-sulfamethoxazol... | [
{
"class": "COMB",
"spans": [
0,
2
],
"is_context_needed": true
}
] | Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis: A Randomized Clinical Trial. Emergency department visits for skin infections in the United States have increased with the emergence of methicillin-resistant Staphylococcus aureus (MRSA). For celluli... | https://pubmed.ncbi.nlm.nih.gov/28535235/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on... |
77e0b10b4077f694602171ec11b8fbad | In the NALA trial , neratinib plus capecitabine led to increased PFS and time to intervention for central nervous system disease over the standard regimen of lapatinib plus capecitabine . | [
{
"span_id": 0,
"text": "neratinib",
"start": 20,
"end": 29,
"token_start": 5,
"token_end": 6
},
{
"span_id": 1,
"text": "capecitabine",
"start": 35,
"end": 47,
"token_start": 7,
"token_end": 8
},
{
"span_id": 2,
"text": "lapatinib",
"start": 158,
... | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
},
{
"class": "POS",
"spans": [
2,
3
],
"is_context_needed": false
}
] | Neratinib plus capecitabine for the treatment of advanced HER2-positive breast cancer. Several agents are being developed for advanced HER2-positive breast cancer, such as potent tyrosine kinase inhibitors (TKI) targeting ErbB family receptors, novel antibody-drug conjugates, higher affinity anti-HER2 antibodies, among... | https://pubmed.ncbi.nlm.nih.gov/32862744/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Neratinib plus capecitabine for the treatment of advanced HER2-positive breast... |
4a18483d052bd05090b82ed366d8e395 | Since the patient had anemia , aspirin and cilostazol were discontinued after diagnosis . | [
{
"span_id": 0,
"text": "aspirin",
"start": 31,
"end": 38,
"token_start": 6,
"token_end": 7
},
{
"span_id": 1,
"text": "cilostazol",
"start": 43,
"end": 53,
"token_start": 8,
"token_end": 9
}
] | [
{
"class": "NEG",
"spans": [
0,
1
],
"is_context_needed": true
}
] | [A Case of Ascending Colon Cancer with Essential Thrombocythemia]. Essential thrombocythemia(ET)is a rare myeloproliferative disorder characterized by thrombocytosis and a risk of thrombotic and hemorrhagic events. ET rarely occurs simultaneously with colorectal cancer. Including our case, only 5 cases of c o l orectal... | https://pubmed.ncbi.nlm.nih.gov/33468948/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
[A Case of Ascending Colon Cancer with Essential Thrombocythemia]. Essential t... |
f53ebc5049fa66cd3aa251a61ce9a16d | This case report describes a patient with O-NHL which was possibly linked to the combination of methotrexate and etanercept for the treatment of her rheumatoid arthritis . | [
{
"span_id": 0,
"text": "methotrexate",
"start": 96,
"end": 108,
"token_start": 16,
"token_end": 17
},
{
"span_id": 1,
"text": "etanercept",
"start": 113,
"end": 123,
"token_start": 18,
"token_end": 19
}
] | [
{
"class": "NEG",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Oral non-Hodgkin's lymphoma in a patient with rheumatoid arthritis treated with etanercept and methotrexate. Oral non-Hodgkin's lymphomas (O-NHLs) are a rare group of diverse lymphoid tissue malignancies and represent less than 5% of the oral cavity malignancies and 2% of all extra-nodal NHLs. Oral-NHLs affect the Wald... | https://pubmed.ncbi.nlm.nih.gov/25810835/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Oral non-Hodgkin's lymphoma in a patient with rheumatoid arthritis treated wit... |
2385bbe94c2fcb3c8d02c68a6e685707 | In a prospective , pragmatic , randomised , parallel group study , 170 patients of mean ( SD ) age 37 ( 12 ) years with acute asthma ( peak expiratory flow ( PEF ) 212 ( 80 ) l/min ) presenting to hospital received treatment with either high dose prednisolone and continuous nebulised salbutamol as recommended in the US... | [
{
"span_id": 0,
"text": "prednisolone",
"start": 247,
"end": 259,
"token_start": 50,
"token_end": 51
},
{
"span_id": 1,
"text": "salbutamol",
"start": 285,
"end": 295,
"token_start": 54,
"token_end": 55
},
{
"span_id": 2,
"text": "prednisolone",
"s... | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Randomised pragmatic comparison of UK and US treatment of acute asthma presenting to hospital. Systemic corticosteroids and inhaled beta(2) agonists are accepted first line treatments for acute severe asthma, but there is no consensus on their optimum dosage and frequency of administration. American regimens include hi... | https://pubmed.ncbi.nlm.nih.gov/12454298/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Randomised pragmatic comparison of UK and US treatment of acute asthma present... |
e4e7a7e096b8a824afdb91ec6603eba7 | We report a case of a 78-year-old white male ( weight , 90 kg ) presented to the Department of Medical Oncology and Hematology , Istituto Clinico Humanitas , Rozzano , Milan , Italy , with refractory MM immunoglobulin G kappa ( IgGkappa ) , Durie-Salmon Stage IIA , with progressive renal failure after an oral melphalan... | [
{
"span_id": 0,
"text": "melphalan",
"start": 311,
"end": 320,
"token_start": 56,
"token_end": 57
},
{
"span_id": 1,
"text": "prednisone",
"start": 323,
"end": 333,
"token_start": 58,
"token_end": 59
},
{
"span_id": 2,
"text": "thalidomide",
"start... | [
{
"class": "NEG",
"spans": [
0,
1,
2
],
"is_context_needed": false
}
] | Bortezomib-dexamethasone combination in a patient with refractory multiple myeloma and impaired renal function. Multiple myeloma (MM) is a hematologic neoplasia characterized by the monoclonal proliferation of bone marrow plasma cells. Renal failure occurs in 20% to 30% of MM patients at diagnosis and in >50% with an a... | https://pubmed.ncbi.nlm.nih.gov/16860177/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Bortezomib-dexamethasone combination in a patient with refractory multiple mye... |
15b396da057bf3eb9a6ad966cb34cf79 | Following an intravitreal injection of ranibizumab , off-label administration of intravitreal dexamethasone was considered to reduce the edema . | [
{
"span_id": 0,
"text": "ranibizumab",
"start": 39,
"end": 50,
"token_start": 5,
"token_end": 6
},
{
"span_id": 1,
"text": "dexamethasone",
"start": 94,
"end": 107,
"token_start": 11,
"token_end": 12
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Effect of intravitreal dexamethasone on macular edema in von Hippel-Lindau disease assessed using swept-source optical coherence tomography: a case report. Von Hippel-Lindau disease is a rare hereditary syndrome caused by germinal mutations in a von Hippel-Lindau tumor-suppressing gene. Retinal hemangioblastoma is the ... | https://pubmed.ncbi.nlm.nih.gov/30185211/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Effect of intravitreal dexamethasone on macular edema in von Hippel-Lindau dis... |
39c5dd43cb040ee8f6350c3f2071e992 | Rabeprazole was similar to omeprazole and superior to placebo in both maintenance of healing and prevention of symptoms in patients with healed GERD in 1-year studies . | [
{
"span_id": 0,
"text": "Rabeprazole",
"start": 0,
"end": 11,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "omeprazole",
"start": 27,
"end": 37,
"token_start": 4,
"token_end": 5
}
] | [] | Rabeprazole: a review of its use in acid-related gastrointestinal disorders. rabeprazole is an inhibitor of the gastric proton pump. It causes dose-dependent inhibition of acid secretion and has a more rapid onset of action than omeprazole. Duodenal ulcers healed faster after treatment with rabeprazole 20 or 40 mg/day ... | https://pubmed.ncbi.nlm.nih.gov/10551440/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Rabeprazole: a review of its use in acid-related gastrointestinal disorders. r... |
aea6e5bbd17d903de73866d5840bb07f | We performed a prospective , preplanned , pooled analysis of six randomized , phase 3 trials that were conducted concurrently to evaluate the noninferiority of adjuvant therapy with either FOLFOX ( fluorouracil , leucovorin , and oxaliplatin ) or CAPOX ( capecitabine and oxaliplatin ) administered for 3 months , as com... | [
{
"span_id": 0,
"text": "fluorouracil",
"start": 198,
"end": 210,
"token_start": 31,
"token_end": 32
},
{
"span_id": 1,
"text": "leucovorin",
"start": 213,
"end": 223,
"token_start": 33,
"token_end": 34
},
{
"span_id": 2,
"text": "oxaliplatin",
"st... | [
{
"class": "POS",
"spans": [
3,
4
],
"is_context_needed": true
},
{
"class": "COMB",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | Duration of Adjuvant Chemotherapy for Stage III Colon Cancer. Since 2004, a regimen of 6 months of treatment with oxaliplatin plus a fluoropyrimidine has been standard adjuvant therapy in patients with stage III colon cancer. However, since oxaliplatin is associated with cumulative neurotoxicity, a shorter duration of ... | https://pubmed.ncbi.nlm.nih.gov/29590544/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Duration of Adjuvant Chemotherapy for Stage III Colon Cancer. Since 2004, a re... |
c2b21e29d41a7690c76cf73efa04e478 | Growth inhibition and apoptosis were significantly ( P < 0.05 ) higher in BxPC-3 , HPAC , and PANC-1 cells treated with celecoxib and erlotinib than cells treated with either celecoxib or erlotinib . | [
{
"span_id": 0,
"text": "celecoxib",
"start": 120,
"end": 129,
"token_start": 22,
"token_end": 23
},
{
"span_id": 1,
"text": "erlotinib",
"start": 134,
"end": 143,
"token_start": 24,
"token_end": 25
},
{
"span_id": 2,
"text": "celecoxib",
"start": ... | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Simultaneous targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways for pancreatic cancer therapy. The aims of this study were to determine the effects of (a) combining the epidermal growth factor receptor (EGFR) blocker (erlotinib) and the cyclooxygenase-2 inhibitor (celecoxib) on cell growth ... | https://pubmed.ncbi.nlm.nih.gov/16373709/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Simultaneous targeting of the epidermal growth factor receptor and cyclooxygen... |
d85f44a5e953a3b8e43b5bf99e30a3b5 | Subcutaneous aspirin , 100 mg/kg , which reduced duodenal PGE2 generation to a greater degree than either ulcerogen , given in conjunction with pentagastrin , did not produce visible duodenal ulceration.(ABSTRACT TRUNCATED AT 250 WORDS ) | [
{
"span_id": 0,
"text": "aspirin",
"start": 13,
"end": 20,
"token_start": 1,
"token_end": 2
},
{
"span_id": 1,
"text": "pentagastrin",
"start": 144,
"end": 156,
"token_start": 23,
"token_end": 24
}
] | [] | Role of prostanoids in experimental duodenal ulcer in rat. The purposes of this study were to determine whether inhibition of cyclooxygenase is a mechanism by which cysteamine and mepirizole produce duodenal ulcers, identify qualitative or quantitative differences in prostanoid production between gastric mucosa and duo... | https://pubmed.ncbi.nlm.nih.gov/3131076/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Role of prostanoids in experimental duodenal ulcer in rat. The purposes of thi... |
4c286a03b81e5883cc213110576889fa | Prevalence of metronidazole , clarithromycin , and amoxicillin resistance is high in developing world including Africa . | [
{
"span_id": 0,
"text": "metronidazole",
"start": 14,
"end": 27,
"token_start": 2,
"token_end": 3
},
{
"span_id": 1,
"text": "clarithromycin",
"start": 30,
"end": 44,
"token_start": 4,
"token_end": 5
},
{
"span_id": 2,
"text": "amoxicillin",
"start... | [] | The magnitude of antibiotic resistance to Helicobacter pylori in Africa and identified mutations which confer resistance to antibiotics: systematic review and meta-analysis. Worldwide Helicobacter pylori (H.pylori) treatment is of great challenge due to increased antibiotic resistance. The burden of H. pylori antibioti... | https://pubmed.ncbi.nlm.nih.gov/29699490/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
The magnitude of antibiotic resistance to Helicobacter pylori in Africa and id... |
c17fc0df1fea762c276a5d2457332e93 | These results indicate that low-dose 100 microg levonorgestrel and 20 microg ethinyl estradiol given for 21 days is effective in suppressing ovarian activity and they confirm the contraceptive efficacy observed in clinical trials ( Pearl index of 0.8 ) . | [
{
"span_id": 0,
"text": "levonorgestrel",
"start": 48,
"end": 62,
"token_start": 7,
"token_end": 8
},
{
"span_id": 1,
"text": "ethinyl",
"start": 77,
"end": 84,
"token_start": 11,
"token_end": 12
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
}
] | The effects on ovarian activity of a monophasic oral contraceptive with 100 microg levonorgestrel and 20 microg ethinyl estradiol. An open-label, single-center, noncomparative study was conducted to determine the effects of a monophasic oral contraceptive containing 100 microg levonorgestrel and 20 microg ethinyl estra... | https://pubmed.ncbi.nlm.nih.gov/10561676/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
The effects on ovarian activity of a monophasic oral contraceptive with 100 mi... |
f5280bfb01586dd9949743d020881015 | The combination of ixabepilone and capecitabine in the phase II study resulted in an ORR of 23 % in triple-negative patients . | [
{
"span_id": 0,
"text": "ixabepilone",
"start": 19,
"end": 30,
"token_start": 3,
"token_end": 4
},
{
"span_id": 1,
"text": "capecitabine",
"start": 35,
"end": 47,
"token_start": 5,
"token_end": 6
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Efficacy of ixabepilone in ER/PR/HER2-negative (triple-negative) breast cancer. Patients with ER/PR/HER2-negative (triple negative) breast cancer are not candidates for hormonal therapy or HER2-targeted agents. Ongoing research is aimed at identifying and understanding the benefit of established and emerging therapies ... | https://pubmed.ncbi.nlm.nih.gov/20229176/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Efficacy of ixabepilone in ER/PR/HER2-negative (triple-negative) breast cancer... |
f1876516f12f16458a9741e1e09fd6e9 | We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that was marked by rapid tumor necrosis followed by massive hemorrhage shortly after bevacizumab and paclitaxel administration . | [
{
"span_id": 0,
"text": "bevacizumab",
"start": 182,
"end": 193,
"token_start": 28,
"token_end": 29
},
{
"span_id": 1,
"text": "paclitaxel",
"start": 198,
"end": 208,
"token_start": 30,
"token_end": 31
}
] | [
{
"class": "NEG",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Rapid tumor necrosis and massive hemorrhage induced by bevacizumab and paclitaxel combination therapy in a case of advanced breast cancer. bevacizumab when combined with chemotherapy exerts significant activity against many solid tumors through tumor angiogenesis inhibition; however, it can induce severe side effects. ... | https://pubmed.ncbi.nlm.nih.gov/24124381/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Rapid tumor necrosis and massive hemorrhage induced by bevacizumab and paclita... |
5b276187d854e37f1e11f2a96b3f7f34 | More recently , paclitaxel plus carboplatin also has been evaluated in previously untreated patients . | [
{
"span_id": 0,
"text": "paclitaxel",
"start": 16,
"end": 26,
"token_start": 3,
"token_end": 4
},
{
"span_id": 1,
"text": "carboplatin",
"start": 32,
"end": 43,
"token_start": 5,
"token_end": 6
}
] | [
{
"class": "COMB",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Current status of chemotherapy for ovarian cancer. Standard treatment for patients with advanced ovarian cancer has been cytoreductive surgery followed by combination chemotherapy. Until recently, platinum-based chemotherapy was considered optimal and patients were treated with regimens built around either cisplatin or... | https://pubmed.ncbi.nlm.nih.gov/7481863/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Current status of chemotherapy for ovarian cancer. Standard treatment for pati... |
a29a75ad6709d12bac212da17d06c3d6 | Mitoxantrone and cyclophosphamide in advanced breast cancer : a pilot study . | [
{
"span_id": 0,
"text": "Mitoxantrone",
"start": 0,
"end": 12,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "cyclophosphamide",
"start": 17,
"end": 33,
"token_start": 2,
"token_end": 3
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Mitoxantrone and cyclophosphamide in advanced breast cancer : a pilot study . A trial of combination chemotherapy using mitoxantrone-cyclophosphamide was started in 1983. Sixteen patients with widely metastatic cancer of the breast, including one man, received mitoxantrone, 10 mg/m2 intravenously (IV) over 30 minutes o... | https://pubmed.ncbi.nlm.nih.gov/6385260/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Mitoxantrone and cyclophosphamide in advanced breast cancer : a pilot study . ... |
1106afc2c9fb4c7a9ae5de454d4c4e8e | We retrospectively analyzed the data of 37 patients who had postprandial hyperglycemia ( ≥10.0 mmol/L ) with BOT ( long-acting insulin plus glimepiride ) with their insulin titrated enough to keep preprandial glycemia < 7.2 mmol/L , and who had their treatment changed to liraglutide monotherapy , with the subsequent ad... | [
{
"span_id": 0,
"text": "glimepiride",
"start": 140,
"end": 151,
"token_start": 22,
"token_end": 23
},
{
"span_id": 1,
"text": "liraglutide",
"start": 272,
"end": 283,
"token_start": 44,
"token_end": 45
},
{
"span_id": 2,
"text": "glimepiride",
"st... | [
{
"class": "COMB",
"spans": [
1,
2
],
"is_context_needed": true
}
] | Efficacy of liraglutide therapy in Japanese type 2 diabetic patients insufficiently controlled with basal-supported oral therapy. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2012.00223.x, 2012) Aims/Introduction: We assessed the efficacy of liraglutide therapy in Japanese type 2 diabetic patients insufficiently contr... | https://pubmed.ncbi.nlm.nih.gov/24843616/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Efficacy of liraglutide therapy in Japanese type 2 diabetic patients insuffici... |
be5a1c925d0cb0e6d439ac0b5e827128 | It was shown that the H2 receptor antagonist cimetidine when combined with N , N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl ( DPPE ) , a tamoxifen derivate , inhibits the proliferation of HT168 cells . | [
{
"span_id": 0,
"text": "cimetidine",
"start": 45,
"end": 55,
"token_start": 8,
"token_end": 9
},
{
"span_id": 1,
"text": "DPPE",
"start": 134,
"end": 138,
"token_start": 16,
"token_end": 17
},
{
"span_id": 2,
"text": "tamoxifen",
"start": 145,
... | [
{
"class": "POS",
"spans": [
0,
1,
3
],
"is_context_needed": false
}
] | Cimetidine and a tamoxifen derivate reduce tumour formation in SCID mice xenotransplanted with a human melanoma cell line. Histamine is produced by many cells expressing histidine decarboxylase (HDC), the enzyme responsible for the synthesis of histamine. Since melanoma cells and tissue contain relatively large amounts... | https://pubmed.ncbi.nlm.nih.gov/12140379/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Cimetidine and a tamoxifen derivate reduce tumour formation in SCID mice xenot... |
371012fb02d83cd72167038138c75fc9 | We report here on a case of successful treatment of a patient suffering with severe liver dysfunction and metastatic gastric cancer ; the patient was treated with a combination of capecitabine and oxaliplatin ( XELOX ) . | [
{
"span_id": 0,
"text": "capecitabine",
"start": 180,
"end": 192,
"token_start": 30,
"token_end": 31
},
{
"span_id": 1,
"text": "oxaliplatin",
"start": 197,
"end": 208,
"token_start": 32,
"token_end": 33
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Capecitabine and oxaliplatin (XELOX) for the treatment of patients with metastatic gastric cancer and severe liver dysfunction. Gastric cancer patients with severe liver dysfunction secondary to hepatic metastases have limited treatment options. Most cytotoxic drugs have a narrow therapeutic index. Although both capeci... | https://pubmed.ncbi.nlm.nih.gov/17249509/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Capecitabine and oxaliplatin (XELOX) for the treatment of patients with metast... |
866cea479a93e1b7b5b53f5813e3c8af | From 1987 to 1991 , 194 previously untreated patients received vincristine and ifosfamide plus dactinomycin or etoposide for 1 - 2 years . | [
{
"span_id": 0,
"text": "vincristine",
"start": 63,
"end": 74,
"token_start": 10,
"token_end": 11
},
{
"span_id": 1,
"text": "ifosfamide",
"start": 79,
"end": 89,
"token_start": 12,
"token_end": 13
},
{
"span_id": 2,
"text": "dactinomycin",
"start"... | [
{
"class": "NEG",
"spans": [
0,
1,
2
],
"is_context_needed": true
},
{
"class": "NEG",
"spans": [
0,
1,
3
],
"is_context_needed": true
}
] | Renal toxicity of ifosfamide in pilot regimens of the intergroup rhabdomyosarcoma study for patients with gross residual tumor. The purpose of this review is to characterize the nephrotoxicity noted in newly diagnosed patients under 21 years of age after treatment with ifosfamide-containing chemotherapy regimens and lo... | https://pubmed.ncbi.nlm.nih.gov/7978043/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Renal toxicity of ifosfamide in pilot regimens of the intergroup rhabdomyosarc... |
8e992315910c8453b24e152e7b079ea9 | This nested substudy of the AVALON trial assessed the effects of coadministered amlodipine and atorvastatin vs. either therapy alone or placebo on arterial compliance , to evaluate the vascular benefits of coadministered therapy . | [
{
"span_id": 0,
"text": "amlodipine",
"start": 80,
"end": 90,
"token_start": 12,
"token_end": 13
},
{
"span_id": 1,
"text": "atorvastatin",
"start": 95,
"end": 107,
"token_start": 14,
"token_end": 15
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Coadministered amlodipine and atorvastatin produces early improvements in arterial wall compliance in hypertensive patients with dyslipidemia. Combining statins with antihypertensive therapy has been demonstrated to provide an early reduction in cardiovascular events. This nested substudy of the AVALON trial assessed t... | https://pubmed.ncbi.nlm.nih.gov/19057518/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Coadministered amlodipine and atorvastatin produces early improvements in arte... |
e925c82c9d2d2338c659d275057e5ecd | We analysed the serial dermatoscopic photographs of atypical melanocytic lesions taken from patients with advanced metastatic melanoma on four different systemic therapies ( selective BRAF-inhibitor monotherapy , dabrafenib combined with trametinib [ D&T ] , anti-programmed cell death protein 1 [ anti-PD1 ] therapies ,... | [
{
"span_id": 0,
"text": "dabrafenib",
"start": 213,
"end": 223,
"token_start": 27,
"token_end": 28
},
{
"span_id": 1,
"text": "trametinib",
"start": 238,
"end": 248,
"token_start": 30,
"token_end": 31
},
{
"span_id": 2,
"text": "anti-PD1",
"start":... | [
{
"class": "COMB",
"spans": [
0,
1
],
"is_context_needed": true
},
{
"class": "COMB",
"spans": [
2,
3
],
"is_context_needed": true
}
] | Melanocytic lesion evolution patterns with targeted therapies and immunotherapies for advanced metastatic melanoma: An observational study. Various cutaneous side-effects have been reported with anti-melanoma systemic therapies. This study investigated the changes in melanocytic lesion pigmentation in patients on four ... | https://pubmed.ncbi.nlm.nih.gov/28707403/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Melanocytic lesion evolution patterns with targeted therapies and immunotherap... |
05b1012375dc91d3f46f44b59e1fd1fb | He received six cycles MOPP-induction therapy followed by a chlorambucil maintenance therapy with procarbazine and prednisone reinforcements . | [
{
"span_id": 0,
"text": "chlorambucil",
"start": 60,
"end": 72,
"token_start": 9,
"token_end": 10
},
{
"span_id": 1,
"text": "procarbazine",
"start": 98,
"end": 110,
"token_start": 13,
"token_end": 14
},
{
"span_id": 2,
"text": "prednisone",
"start... | [
{
"class": "NEG",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | Acute erythroleukemia following chemotherapy for Hodgkin's disease. A case of erythroleukemia developing in a patient 6.5 years after therapy for Hodgkin's disease (HD) is described. The patient had chemotherapy alone for a stage III B lymphocyte-predominant HD. He received six cycles MOPP-induction therapy followed by... | https://pubmed.ncbi.nlm.nih.gov/6932816/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Acute erythroleukemia following chemotherapy for Hodgkin's disease. A case of ... |
a361c296e0a5fe7615178d1738c3cc72 | The introduction of rituximab , alemtuzumab , and bendamustine has improved the current outlook for patients with CLL . | [
{
"span_id": 0,
"text": "rituximab",
"start": 20,
"end": 29,
"token_start": 3,
"token_end": 4
},
{
"span_id": 1,
"text": "alemtuzumab",
"start": 32,
"end": 43,
"token_start": 5,
"token_end": 6
},
{
"span_id": 2,
"text": "bendamustine",
"start": 50,... | [] | Standard of care and novel treatments for chronic lymphocytic leukemia. The standard of care and novel treatments for chronic lymphocytic leukemia (CLL) are reviewed. ### summary Recent advances in the treatment of CLL have dramatically changed the therapeutic landscape for both patients and health care professionals. ... | https://pubmed.ncbi.nlm.nih.gov/20966144/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Standard of care and novel treatments for chronic lymphocytic leukemia. The st... |
4459519c47bc0fd3fbadcc6fff8f621d | Ten patients were treated with pirfenidone ( 2403 mg/die ) and 1 with nintedanib | [
{
"span_id": 0,
"text": "pirfenidone",
"start": 31,
"end": 42,
"token_start": 5,
"token_end": 6
},
{
"span_id": 1,
"text": "nintedanib",
"start": 70,
"end": 80,
"token_start": 13,
"token_end": 14
}
] | [] | Possible value of antifibrotic drugs in patients with progressive fibrosing non-IPF interstitial lung diseases. Fibrosing, non-idiopathic pulmonary fibrosis (non-IPF) interstitial lung diseases (fILDs) are a heterogeneous group of diseases characterized by a different amount of inflammation and fibrosis. Therapy is cur... | https://pubmed.ncbi.nlm.nih.gov/31718637/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Possible value of antifibrotic drugs in patients with progressive fibrosing no... |
aca07ce099defc39959faeabed961a9a | More recently , case-control and cohort studies and well-conceived , phase II/III clinical trials have been done or are under way to evaluate putative chemopreventive agents including established drugs like aspirin and non-steroidal anti-inflammatory drugs ( NSAIDs ) , 5-aminosalicylates and statins ; more controversia... | [
{
"span_id": 0,
"text": "aspirin",
"start": 207,
"end": 214,
"token_start": 30,
"token_end": 31
},
{
"span_id": 1,
"text": "5-aminosalicylates",
"start": 270,
"end": 288,
"token_start": 39,
"token_end": 40
},
{
"span_id": 2,
"text": "cyclo-oxygenase-2"... | [] | Chemoprevention of colorectal cancer. Colorectal cancer is a major cause of mortality and treatment costs are considerable. Advocating lifestyle modification, faecal occult blood testing and surveillance colonoscopy in appropriate populations are already in practice. A developing concept is chemoprevention. Several mod... | https://pubmed.ncbi.nlm.nih.gov/17947819/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Chemoprevention of colorectal cancer. Colorectal cancer is a major cause of mo... |
121cc940e6c7801b8ef91dd420bbcd5a | Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma : a multicentre phase II study . | [
{
"span_id": 0,
"text": "bortezomib",
"start": 10,
"end": 20,
"token_start": 1,
"token_end": 2
},
{
"span_id": 1,
"text": "rituximab",
"start": 25,
"end": 34,
"token_start": 3,
"token_end": 4
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma : a multicentre phase II study . There is a lack of published data examining non-cytotoxic options for the frontline treatment of patients with high-tumour burden (HTB) indolent non-Hodgkin lymphoma ... | https://pubmed.ncbi.nlm.nih.gov/24761968/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Frontline bortezomib and rituximab for the treatment of newly diagnosed high t... |
2a53d260b295d78e2f2e900107f15b71 | The ifosfamide , carboplatin and etoposide ( ICE ) regimen was developed to address these challenges . | [
{
"span_id": 0,
"text": "ifosfamide",
"start": 4,
"end": 14,
"token_start": 1,
"token_end": 2
},
{
"span_id": 1,
"text": "carboplatin",
"start": 17,
"end": 28,
"token_start": 3,
"token_end": 4
},
{
"span_id": 2,
"text": "etoposide",
"start": 33,
... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | Ifosfamide, carboplatin, etoposide (ICE)-based second-line chemotherapy for the management of relapsed and refractory aggressive non-Hodgkin's lymphoma. Despite advances in the management of aggressive non-Hodgkin's lymphoma, the treatment of relapsed and primary refractory disease remains a major challenge. High-dose ... | https://pubmed.ncbi.nlm.nih.gov/12736224/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Ifosfamide, carboplatin, etoposide (ICE)-based second-line chemotherapy for th... |
b740d6e2917c26c5d772eb2155529a4f | Tofacitinib combination therapy was also associated with the lower PMPM cost compared with adalimumab combination therapy in the TNF-IR analysis . | [
{
"span_id": 0,
"text": "Tofacitinib",
"start": 0,
"end": 11,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "adalimumab",
"start": 91,
"end": 101,
"token_start": 13,
"token_end": 14
}
] | [] | An Economic Evaluation of Tofacitinib Treatment in Rheumatoid Arthritis: Modeling the Cost of Treatment Strategies in the United States. tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). tofacitinib is approved in the United States for use in adults with moderately to severel... | https://pubmed.ncbi.nlm.nih.gov/27579831/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
An Economic Evaluation of Tofacitinib Treatment in Rheumatoid Arthritis: Model... |
aa7244029b3ff67b517ef6f9a89e4e34 | Effect of sequential treatments with alendronate , parathyroid hormone ( 1 - 34 ) and raloxifene on cortical bone mass and strength in ovariectomized rats . | [
{
"span_id": 0,
"text": "alendronate",
"start": 37,
"end": 48,
"token_start": 5,
"token_end": 6
},
{
"span_id": 1,
"text": "parathyroid hormone",
"start": 51,
"end": 70,
"token_start": 7,
"token_end": 9
},
{
"span_id": 2,
"text": "raloxifene",
"sta... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | Effect of sequential treatments with alendronate , parathyroid hormone ( 1 - 34 ) and raloxifene on cortical bone mass and strength in ovariectomized rats . Anti-resorptive and anabolic agents are often prescribed for the treatment of osteoporosis continuously or sequentially for many years. However their impact on cor... | https://pubmed.ncbi.nlm.nih.gov/25016965/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Effect of sequential treatments with alendronate , parathyroid hormone ( 1 - 3... |
b701ddeb0bd97b91f62fe6b654023d06 | Atorvastatin and metformin both have pleiotropic effects . | [
{
"span_id": 0,
"text": "Atorvastatin",
"start": 0,
"end": 12,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "metformin",
"start": 17,
"end": 26,
"token_start": 2,
"token_end": 3
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Atorvastatin Plus Metformin Confer Additive Benefits on Subjects with Dyslipidemia and Overweight/Obese via Reducing ROCK2 Concentration. Atorvastatin and metformin both have pleiotropic effects . Whether atorvastatin combined with metformin could provide additive benefits on subjects with dyslipidemia and overweight/... | https://pubmed.ncbi.nlm.nih.gov/27123784/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Atorvastatin Plus Metformin Confer Additive Benefits on Subjects with Dyslipid... |
3ddf01008a6da5a27b7b3ed32a532cba | Bevacizumab , a monoclonal antibody targeting vascular endothelial growth factor , is the first antiangiogenic drug to show improved efficacy when used in combination with irinotecan and oxaliplatin for first- and second-line treatment of CRC . | [
{
"span_id": 0,
"text": "Bevacizumab",
"start": 0,
"end": 11,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "irinotecan",
"start": 172,
"end": 182,
"token_start": 25,
"token_end": 26
},
{
"span_id": 2,
"text": "oxaliplatin",
"start": ... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": false
}
] | Targeted agents for adjuvant therapy of colon cancer. Among patients with colorectal cancer (CRC) diagnosed in the United States, 37.2% are diagnosed with stage III and 27.9% with stage II disease. In locoregionally advanced CRC, surgery is the primary treatment modality and has a curative intent. The survival depends ... | https://pubmed.ncbi.nlm.nih.gov/16796791/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Targeted agents for adjuvant therapy of colon cancer. Among patients with colo... |
f53a76b0f77943392506a7584cb6fb49 | Available data indicate that GLY and aclidinium have similar efficacy to tiotropium in terms of improving lung function , dyspnea , exacerbations , and health status . | [
{
"span_id": 0,
"text": "GLY",
"start": 29,
"end": 32,
"token_start": 4,
"token_end": 5
},
{
"span_id": 1,
"text": "aclidinium",
"start": 37,
"end": 47,
"token_start": 6,
"token_end": 7
},
{
"span_id": 2,
"text": "tiotropium",
"start": 73,
"end... | [] | Practical considerations when prescribing a long-acting muscarinic antagonist for patients with COPD. COPD is characterized by persistent airflow limitation, progressive breathlessness, cough, and sputum production. Long-acting muscarinic antagonists (LAMAs) are one of the recommended first-choice therapeutic options f... | https://pubmed.ncbi.nlm.nih.gov/29670345/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Practical considerations when prescribing a long-acting muscarinic antagonist ... |
3d0d59d4e485f6a55293b551396a97b1 | Between Oct 24 , 2016 , and Jan 24 , 2018 , 861 patients were randomly assigned to receive pembrolizumab plus axitinib ( n=432 ) or sunitinib monotherapy ( n=429 ) . | [
{
"span_id": 0,
"text": "pembrolizumab",
"start": 91,
"end": 104,
"token_start": 19,
"token_end": 20
},
{
"span_id": 1,
"text": "axitinib",
"start": 110,
"end": 118,
"token_start": 21,
"token_end": 22
},
{
"span_id": 2,
"text": "sunitinib",
"start"... | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Pembrolizumab plus axitinib versus sunitinib monotherapy as first-line treatment of advanced renal cell carcinoma (KEYNOTE-426): extended follow-up from a randomised, open-label, phase 3 trial. The first interim analysis of the KEYNOTE-426 study showed superior efficacy of pembrolizumab plus axitinib over sunitinib mon... | https://pubmed.ncbi.nlm.nih.gov/33284113/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Pembrolizumab plus axitinib versus sunitinib monotherapy as first-line treatme... |
d762cec75711543c49da82dff94ed22a | Patients received 175 mg/m of paclitaxel over a 3 h infusion , followed by nedaplatin 80 mg/m in a 1 h infusion on day 1 every 3 weeks for up to 6 treatment cycles . | [
{
"span_id": 0,
"text": "paclitaxel",
"start": 30,
"end": 40,
"token_start": 5,
"token_end": 6
},
{
"span_id": 1,
"text": "nedaplatin",
"start": 75,
"end": 85,
"token_start": 14,
"token_end": 15
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | A retrospective study of paclitaxel combining nedaplatin chemotherapy for esophageal cancer. The aim of this study was to evaluate the efficacy and tolerability of the combination of paclitaxel and nedaplatin in patients with advanced esophageal cancer. Patients (n = 310) with recurrent or metastatic esophageal squamou... | https://pubmed.ncbi.nlm.nih.gov/25222530/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A retrospective study of paclitaxel combining nedaplatin chemotherapy for esop... |
b6c21f8f5634747e728badfc6d8eb528 | After a median follow-up of 9.5 years , 10-year OS rates in the bolus/infusional fluorouracil plus leucovorin ( LV5FU2 ) and LV5FU2 plus oxaliplatin ( FOLFOX4 ) arms were 67.1 % versus 71.7 % ( hazard ratio [ HR ] , 0.85 ; P = .043 ) in the whole population , 79.5 % versus 78.4 % for stage II ( HR , 1.00 ; P = .980 ) ,... | [
{
"span_id": 0,
"text": "fluorouracil",
"start": 81,
"end": 93,
"token_start": 14,
"token_end": 15
},
{
"span_id": 1,
"text": "leucovorin",
"start": 99,
"end": 109,
"token_start": 16,
"token_end": 17
},
{
"span_id": 2,
"text": "LV5FU2",
"start": 12... | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
},
{
"class": "POS",
"spans": [
2,
3
],
"is_context_needed": true
}
] | Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study. The MOSAIC (Multicenter International Study of oxaliplatin/fluorouracil/leucovorin in the Adjuvant Treatment of Colon Cance... | https://pubmed.ncbi.nlm.nih.gov/26527776/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Ca... |
89852eabc5c5a033839f43602db85e9b | [ Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs ] . | [
{
"span_id": 0,
"text": "dofetilide",
"start": 29,
"end": 39,
"token_start": 6,
"token_end": 7
},
{
"span_id": 1,
"text": "verapamil",
"start": 44,
"end": 53,
"token_start": 8,
"token_end": 9
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | [ Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs ] . To test the effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs. ### methods Under the stimulation of different frequencies (0.2, 0.5, 1.0, 1.... | https://pubmed.ncbi.nlm.nih.gov/19950594/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
[ Effects of combined use of dofetilide and verapamil on the action potential ... |
e54f6bdb2e26e38522cbd9d86f9cda86 | Patients with pancreatic adenocarcinoma , pre-treated with gemcitabine-based chemotherapy , were treated with capecitabine ( 800 mg/m(2 ) orally , twice a day for 14 days ) and docetaxel ( 75 mg/m(2 ) i.v , on day 1 ) , every 3 weeks . | [
{
"span_id": 0,
"text": "capecitabine",
"start": 110,
"end": 122,
"token_start": 13,
"token_end": 14
},
{
"span_id": 1,
"text": "docetaxel",
"start": 177,
"end": 186,
"token_start": 28,
"token_end": 29
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Second-line chemotherapy with capecitabine (Xeloda) and docetaxel (Taxotere) in previously treated, unresectable adenocarcinoma of pancreas: the final results of a phase II trial. To investigate the efficacy and toxicity of the docetaxel and capecitabine combination in patients with previously treated, unresectable ade... | https://pubmed.ncbi.nlm.nih.gov/20428874/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Second-line chemotherapy with capecitabine (Xeloda) and docetaxel (Taxotere) i... |
e57340a652b30cdb82156c64b7b39d08 | Comparative study of dose escalation versus interval reduction to obtain dose-intensification of epirubicin and cyclophosphamide with granulocyte colony-stimulating factor in advanced breast cancer . | [
{
"span_id": 0,
"text": "epirubicin",
"start": 97,
"end": 107,
"token_start": 12,
"token_end": 13
},
{
"span_id": 1,
"text": "cyclophosphamide",
"start": 112,
"end": 128,
"token_start": 14,
"token_end": 15
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Comparative study of dose escalation versus interval reduction to obtain dose-intensification of epirubicin and cyclophosphamide with granulocyte colony-stimulating factor in advanced breast cancer . A potential application of hematopoietic growth factors is to obtain an increased dose-intensity. This can be achieved b... | https://pubmed.ncbi.nlm.nih.gov/9193328/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Comparative study of dose escalation versus interval reduction to obtain dose-... |
90f9283bb0869bd11721e467f718e869 | The hearts were treated during the whole procedure either with vehicle , 0.5 μM flecainide ( sodium channel blocker ) or 100 μM streptomycin ( here used as stretch-activated ion-channel blocker ) . | [
{
"span_id": 0,
"text": "flecainide",
"start": 80,
"end": 90,
"token_start": 14,
"token_end": 15
},
{
"span_id": 1,
"text": "streptomycin",
"start": 128,
"end": 140,
"token_start": 23,
"token_end": 24
}
] | [
{
"class": "COMB",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Arrhythmogenic effects by local left ventricular stretch: effects of flecainide and streptomycin. Mechanical stretch has been shown to provoke arrhythmia. We wanted to analyze ventricular arrhythmia induced by local left ventricular stretch in order to find out, where arrhythmias originate and whether they can be preve... | https://pubmed.ncbi.nlm.nih.gov/24858181/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Arrhythmogenic effects by local left ventricular stretch: effects of flecainid... |
fd589e56235bfb107bb352c60763500e | In the APHINITY study ( NCT01358877 , BIG 4 - 11/BO25126/TOC4939 G ) , pertuzumab added to trastuzumab and chemotherapy significantly improved invasive disease-free survival as adjuvant treatment for patients with HER2-positive early breast cancer . | [
{
"span_id": 0,
"text": "pertuzumab",
"start": 71,
"end": 81,
"token_start": 14,
"token_end": 15
},
{
"span_id": 1,
"text": "trastuzumab",
"start": 91,
"end": 102,
"token_start": 17,
"token_end": 18
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Pharmacokinetics of pertuzumab administered concurrently with trastuzumab in Chinese patients with HER2-positive early breast cancer. In the APHINITY study ( NCT01358877 , BIG 4 - 11/BO25126/TOC4939 G ) , pertuzumab added to trastuzumab and chemotherapy significantly improved invasive disease-free survival as adjuvant... | https://pubmed.ncbi.nlm.nih.gov/31305270/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Pharmacokinetics of pertuzumab administered concurrently with trastuzumab in C... |
842c481f52d8e56971342febee357ad0 | In two trials , an anti-EGFR antibody ( panitumumab or cetuximab ) reduced median survival when added to bevacizumab in previously untreated patients . | [
{
"span_id": 0,
"text": "panitumumab",
"start": 40,
"end": 51,
"token_start": 8,
"token_end": 9
},
{
"span_id": 1,
"text": "cetuximab",
"start": 55,
"end": 64,
"token_start": 10,
"token_end": 11
},
{
"span_id": 2,
"text": "bevacizumab",
"start": 10... | [
{
"class": "NEG",
"spans": [
0,
2
],
"is_context_needed": false
},
{
"class": "NEG",
"spans": [
1,
2
],
"is_context_needed": false
}
] | Chemotherapy of metastatic colorectal cancer. Without treatment, patients with inoperable or metastatic colorectal cancer have a median life expectancy of about 8 months. The following article is an update of our 2005 review of chemotherapy regimens used in metastatic colorectal cancer, based on the standard Prescrire ... | https://pubmed.ncbi.nlm.nih.gov/21180382/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Chemotherapy of metastatic colorectal cancer. Without treatment, patients with... |
32d6f9ea24ebefa67b7f337223591178 | The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect . | [
{
"span_id": 0,
"text": "adapalene",
"start": 50,
"end": 59,
"token_start": 8,
"token_end": 9
},
{
"span_id": 1,
"text": "minocycline",
"start": 148,
"end": 159,
"token_start": 23,
"token_end": 24
}
] | [
{
"class": "NEG",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Adapalene Gel 0.1% Versus Placebo as Prophylaxis for Anti-Epidermal Growth Factor Receptor-Induced Acne-Like Rash: A Randomized Left-Right Comparative Evaluation (APPEARANCE). The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and ... | https://pubmed.ncbi.nlm.nih.gov/30890624/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Adapalene Gel 0.1% Versus Placebo as Prophylaxis for Anti-Epidermal Growth Fac... |
fe491984e9df643f36a53c19d1b92689 | Both regimens included cyclophosphamide , methotrexate , 5-FU , prednisone , and doxorubicin . | [
{
"span_id": 0,
"text": "cyclophosphamide",
"start": 23,
"end": 39,
"token_start": 3,
"token_end": 4
},
{
"span_id": 1,
"text": "methotrexate",
"start": 42,
"end": 54,
"token_start": 5,
"token_end": 6
},
{
"span_id": 2,
"text": "5-FU",
"start": 57,... | [
{
"class": "POS",
"spans": [
0,
4
],
"is_context_needed": true
}
] | Randomized comparison of two combination chemotherapy regimens containing doxorubicin in patients with metastatic breast cancer: a Western Cancer Study Group trial. Ninety-six patients with metastatic breast cancer were entered in a prospectively randomized trial comparing a five-drug doxorubicin (Adriamycin)-containin... | https://pubmed.ncbi.nlm.nih.gov/7004635/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Randomized comparison of two combination chemotherapy regimens containing doxo... |
d8c8bee379a8e9440c10b70d55a1dd89 | In 2011 , new drugs were approved by the U.S. Food and Drug Administration , including peginterferon alfa-2b for patients with stage III disease , vemurafenib for patients with metastatic melanoma with the BRAF V600E mutation , and ipilimumab , a monoclonal antibody directed to the CTLA-4 T lymphocyte receptor , to com... | [
{
"span_id": 0,
"text": "peginterferon alfa-2b",
"start": 87,
"end": 108,
"token_start": 16,
"token_end": 18
},
{
"span_id": 1,
"text": "vemurafenib",
"start": 147,
"end": 158,
"token_start": 25,
"token_end": 26
},
{
"span_id": 2,
"text": "ipilimumab",... | [] | Cutaneous melanoma: new advances in treatment. Cutaneous melanoma is a challenge to treat. Over the last 30 years, no drug or combination of drugs demonstrated significant impact to improve patient survival. From 1995 to 2000, the use of cytokines such as interferon and interleukin become treatment options. In 2011 , n... | https://pubmed.ncbi.nlm.nih.gov/24770508/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Cutaneous melanoma: new advances in treatment. Cutaneous melanoma is a challen... |
7710b6d76f366019125879999cf7208f | Individual studies have reported differences between antiandrogens in terms of both tolerability and efficacy-for example , bicalutamide has been shown to be better tolerated than flutamide , and may be associated with improved survival . | [
{
"span_id": 0,
"text": "bicalutamide",
"start": 124,
"end": 136,
"token_start": 16,
"token_end": 17
},
{
"span_id": 1,
"text": "flutamide",
"start": 180,
"end": 189,
"token_start": 25,
"token_end": 26
}
] | [] | Combination hormonal therapy: a reassessment within advanced prostate cancer. Combination hormonal therapy, comprising a luteinising hormone-releasing hormone analogue (LHRHa) with an antiandrogen, is widely used in the treatment of advanced prostate cancer. There is ongoing debate regarding the use of combination horm... | https://pubmed.ncbi.nlm.nih.gov/15365575/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Combination hormonal therapy: a reassessment within advanced prostate cancer. ... |
778960b473d357bcf187c40c2b8bd36f | A Randomized , Multicenter , Double-blind , Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis . | [
{
"span_id": 0,
"text": "Montelukast",
"start": 145,
"end": 156,
"token_start": 24,
"token_end": 25
},
{
"span_id": 1,
"text": "Levocetirizine",
"start": 161,
"end": 175,
"token_start": 26,
"token_end": 27
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | A Randomized , Multicenter , Double-blind , Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis . The aim of this study was to evaluate the efficacy and safety of a fixed-dose combination of mon... | https://pubmed.ncbi.nlm.nih.gov/29945738/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A Randomized , Multicenter , Double-blind , Phase III Study to Evaluate the Ef... |
dec2ee86c2d3ab1e469f8cc6645bcc97 | Intravenous administration of cefoperazone and sulbactam given as individual agents compared with the combination did not show pharmacokinetic differences that are likely to produce clinically relevant effects . | [
{
"span_id": 0,
"text": "cefoperazone",
"start": 30,
"end": 42,
"token_start": 3,
"token_end": 4
},
{
"span_id": 1,
"text": "sulbactam",
"start": 47,
"end": 56,
"token_start": 5,
"token_end": 6
}
] | [
{
"class": "COMB",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Multiple-dose pharmacokinetics and toleration of intravenously administered cefoperazone and sulbactam when given as single agents or in combination. The multiple-dose pharmacokinetics and toleration of cefoperazone (3 g every 12 h) and sulbactam (1.5 g every 12 h) were studied when these antimicrobial agents were admi... | https://pubmed.ncbi.nlm.nih.gov/3348612/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Multiple-dose pharmacokinetics and toleration of intravenously administered ce... |
97fe69f307e811dcf18ff2b21cef466f | HDC with cyclophosphamide , carmustine and thiotepa was given from day -7 to -5 . | [
{
"span_id": 0,
"text": "cyclophosphamide",
"start": 9,
"end": 25,
"token_start": 2,
"token_end": 3
},
{
"span_id": 1,
"text": "carmustine",
"start": 28,
"end": 38,
"token_start": 4,
"token_end": 5
},
{
"span_id": 2,
"text": "thiotepa",
"start": 43... | [
{
"class": "COMB",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | Interleukin-2 and granulocyte-macrophage-colony-stimulating factor immunomodulation with high-dose chemotherapy and autologous hematopoietic stem cell transplantation for patients with metastatic breast cancer. Immunomodulation with cytokines was used to improve the result of high-dose chemotherapy (HDC)/autologous hem... | https://pubmed.ncbi.nlm.nih.gov/19998065/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Interleukin-2 and granulocyte-macrophage-colony-stimulating factor immunomodul... |
44ad2538e2540fa90b878956d4de15df | Melatonin or sulpiride could replace these environmental factors . | [
{
"span_id": 0,
"text": "Melatonin",
"start": 0,
"end": 9,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "sulpiride",
"start": 13,
"end": 22,
"token_start": 2,
"token_end": 3
}
] | [] | Controlling retinal pigment epithelium injury after experimental detachment of the retina. Damage induced by detachment of the neural retina and the retinal pigment epithelium (RPE) can be reduced by dark adaptation. The authors evaluated the influence of the duration of dark adaptation, time of day, and modification o... | https://pubmed.ncbi.nlm.nih.gov/17325183/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Controlling retinal pigment epithelium injury after experimental detachment of... |
1df7aefd099152b9e422ca4f3480841f | Trastuzumab and Pertuzumab Plant Biosimilars : Modification of Asn297-linked Glycan of the mAbs Produced in a Plant with Fucosyltransferase and Xylosyltransferase Gene Knockouts . | [
{
"span_id": 0,
"text": "Trastuzumab",
"start": 0,
"end": 11,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "Pertuzumab",
"start": 16,
"end": 26,
"token_start": 2,
"token_end": 3
}
] | [] | Trastuzumab and Pertuzumab Plant Biosimilars : Modification of Asn297-linked Glycan of the mAbs Produced in a Plant with Fucosyltransferase and Xylosyltransferase Gene Knockouts . Plant biosimilars of anticancer therapeutic antibodies are of interest not only because of the prospects of their practical use, but also as... | https://pubmed.ncbi.nlm.nih.gov/28371609/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Trastuzumab and Pertuzumab Plant Biosimilars : Modification of Asn297-linked G... |
ab76770db4af60662537ffbe504aa0c9 | A recently reported phase II trial has demonstrated that trastuzumab plus vinorelbine is both effective ( overall response rate 75 % ) and well tolerated , with the major side effects being typical of single-agent vinorelbine . | [
{
"span_id": 0,
"text": "trastuzumab",
"start": 57,
"end": 68,
"token_start": 9,
"token_end": 10
},
{
"span_id": 1,
"text": "vinorelbine",
"start": 74,
"end": 85,
"token_start": 11,
"token_end": 12
},
{
"span_id": 2,
"text": "vinorelbine",
"start":... | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
}
] | New combinations with Herceptin in metastatic breast cancer. Preclinical data indicate that trastuzumab (Herceptin) has the potential for synergistic or additive effects in combination with therapies including chemotherapy and hormonal agents, providing the rationale for a number of clinical trials in women with HER2-p... | https://pubmed.ncbi.nlm.nih.gov/11694788/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
New combinations with Herceptin in metastatic breast cancer. Preclinical data ... |
e1c3fcbebfbf9bd3d6eb900c930c8bc1 | Men with prostate cancer were randomly assigned to one of four treatment arms : leuprorelin , goserelin , cyproterone acetate ( CPA ) , or close clinical monitoring . | [
{
"span_id": 0,
"text": "leuprorelin",
"start": 80,
"end": 91,
"token_start": 14,
"token_end": 15
},
{
"span_id": 1,
"text": "goserelin",
"start": 94,
"end": 103,
"token_start": 16,
"token_end": 17
},
{
"span_id": 2,
"text": "cyproterone",
"start":... | [] | Quality of life compared during pharmacological treatments and clinical monitoring for non-localized prostate cancer: a randomized controlled trial. To investigate the effects of different management strategies for non-localized prostate cancer on men's quality of life and cognitive functioning. ### Patients Subjects A... | https://pubmed.ncbi.nlm.nih.gov/15142146/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Quality of life compared during pharmacological treatments and clinical monito... |
7bd97010e6ca716490f2fe6f366d14b6 | There were no significant differences between the two treatment groups , except that amantadine was inferior to mycophenolate mofetil regarding the outcome failure to achieve end-of treatment virological response ( low quality of evidence ) . | [
{
"span_id": 0,
"text": "amantadine",
"start": 85,
"end": 95,
"token_start": 13,
"token_end": 14
},
{
"span_id": 1,
"text": "mycophenolate",
"start": 112,
"end": 125,
"token_start": 17,
"token_end": 18
}
] | [] | Aminoadamantanes versus other antiviral drugs for chronic hepatitis C. Hepatitis C virus infection affects around 3% of the world population or approximately 160 million people. A variable proportion (5% to 40%) of the infected people develop clinical symptoms. Hence, hepatitis C virus is a leading cause of liver-relat... | https://pubmed.ncbi.nlm.nih.gov/24937404/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Aminoadamantanes versus other antiviral drugs for chronic hepatitis C. Hepatit... |
1b70191abaf8f7a0e189322a31ad5a10 | Furthermore , more incidences of severe fatigue , thrombocytopenia , and neutropenia were recorded for sunitinib , but pazopanib had more liver toxicity . | [
{
"span_id": 0,
"text": "sunitinib",
"start": 103,
"end": 112,
"token_start": 15,
"token_end": 16
},
{
"span_id": 1,
"text": "pazopanib",
"start": 119,
"end": 128,
"token_start": 18,
"token_end": 19
}
] | [] | Pazopanib has equivalent anti-tumor effectiveness and lower Total costs than Sunitinib for treating metastatic or advanced renal cell carcinoma: a meta-analysis. sunitinib and pazopanib are extensively used as first-line treatment of metastatic renal cell carcinoma (mRCC). We performed this meta-analysis to assess the ... | https://pubmed.ncbi.nlm.nih.gov/31122210/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Pazopanib has equivalent anti-tumor effectiveness and lower Total costs than S... |
0b7d45d16b3ab6f016d055f1cfd7b822 | Streptomycin appears to be the most effective agent followed by gentamicin and the least active was netilmicin . | [
{
"span_id": 0,
"text": "Streptomycin",
"start": 0,
"end": 12,
"token_start": 0,
"token_end": 1
},
{
"span_id": 1,
"text": "gentamicin",
"start": 64,
"end": 74,
"token_start": 10,
"token_end": 11
},
{
"span_id": 2,
"text": "netilmicin",
"start": 10... | [] | Activity of aminoglycosides against phagocytosed bacteria. The intracellular activity of streptomycin, gentamicin, and netilmicin on Escherichia coli phagocytosed by murine peritoneal macrophages was studied using a sensitive and standardized method. Intracellular activity of streptomycin and gentamicin at therapeutic ... | https://pubmed.ncbi.nlm.nih.gov/1816186/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Activity of aminoglycosides against phagocytosed bacteria. The intracellular a... |
ef0a5c606391305316e0d00ede66a186 | Neither behavioral therapy , clomipramine , methylphenidate , buspirone , nor naltrexone was effective in monotherapeutic trials . | [
{
"span_id": 0,
"text": "clomipramine",
"start": 29,
"end": 41,
"token_start": 4,
"token_end": 5
},
{
"span_id": 1,
"text": "methylphenidate",
"start": 44,
"end": 59,
"token_start": 6,
"token_end": 7
},
{
"span_id": 2,
"text": "buspirone",
"start":... | [] | Comprehensive management of trichotillomania in a young autistic girl. The coexistence of trichotillomania and autistic disorder has rarely been reported in psychiatric literature. The current study describes successful treatment of trichotillomania in a young autistic girl, using combined clomipramine and behavioral t... | https://pubmed.ncbi.nlm.nih.gov/8005911/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Comprehensive management of trichotillomania in a young autistic girl. The coe... |
b95a84fc95f0619053e07be8a81b50c8 | Pharmacokinetic PET imaging data analysis quantitatively showed the pharmacological effects of teriparatide-induced suppression of upper gastrointestinal motility and its restoration by granisetron and mosapride . | [
{
"span_id": 0,
"text": "granisetron",
"start": 186,
"end": 197,
"token_start": 21,
"token_end": 22
},
{
"span_id": 1,
"text": "mosapride",
"start": 202,
"end": 211,
"token_start": 23,
"token_end": 24
}
] | [] | Exploration of Antiemetics for Osteoporosis Therapy-Induced Nausea and Vomiting Using PET Molecular Imaging Analysis to Gastrointestinal Pharmacokinetics. To select appropriate antiemetics relieving teriparatide-induced nausea and vomiting during osteoporosis treatment using PET molecular imaging and pharmacokinetic an... | https://pubmed.ncbi.nlm.nih.gov/26869173/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Exploration of Antiemetics for Osteoporosis Therapy-Induced Nausea and Vomitin... |
836714985a9765014b9095f0827ada4d | Differences were observed when palbociclib or ribociclib was used in combination with letrozole or anastrozole or fulvestrant . | [
{
"span_id": 0,
"text": "palbociclib",
"start": 31,
"end": 42,
"token_start": 4,
"token_end": 5
},
{
"span_id": 1,
"text": "ribociclib",
"start": 46,
"end": 56,
"token_start": 6,
"token_end": 7
},
{
"span_id": 2,
"text": "letrozole",
"start": 86,
... | [
{
"class": "COMB",
"spans": [
0,
2
],
"is_context_needed": true
},
{
"class": "COMB",
"spans": [
0,
3
],
"is_context_needed": true
},
{
"class": "COMB",
"spans": [
0,
4
],
"is_context_needed": true
}
] | First clinical experience with CDK4/6 inhibitors in breast cancer therapy. For hormone receptor-positive, HER2-negative breast cancer patients with metastatic or advanced disease, therapy with CDK4/6 inhibitors in addition to aromatase inhibitors (AIs) or to the estrogen receptor (ER) downregulator fulvestrant has resu... | https://pubmed.ncbi.nlm.nih.gov/33815595/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
First clinical experience with CDK4/6 inhibitors in breast cancer therapy. For... |
df9fa8081eca7b7f4600cb17b04878f1 | Resolution of muscle damage followed discontinuation of cyclosporine and lovastatin therapy . | [
{
"span_id": 0,
"text": "cyclosporine",
"start": 56,
"end": 68,
"token_start": 7,
"token_end": 8
},
{
"span_id": 1,
"text": "lovastatin",
"start": 73,
"end": 83,
"token_start": 9,
"token_end": 10
}
] | [
{
"class": "NEG",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients. Hyperlipidemia, particularly hypercholesterolemia, occurs in cardiac transplant recipients both as a preexisting condition and as a consequence of immunosuppressive therapy. lovastatin (Mevacor) has emerged as an ... | https://pubmed.ncbi.nlm.nih.gov/3290520/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in ca... |
0297c1d33bb07c4fa544ea21c302579a | In order to elucidate the possible interference of the antiparkinson drug 1-aminoadamantane ( D-1 , PK Merz ) and the antispastic compound 1,3-dimethyl-5-aminoadamantane ( DMAA , D-145 , memantine , Memantine ) on neurotransmitter metabolism , the effect of D-1 and its C-alkyl derivatives memantine , 1-amino-3,5,7-trim... | [
{
"span_id": 0,
"text": "PK Merz",
"start": 100,
"end": 107,
"token_start": 15,
"token_end": 17
},
{
"span_id": 1,
"text": "memantine",
"start": 187,
"end": 196,
"token_start": 28,
"token_end": 29
},
{
"span_id": 2,
"text": "Memantine",
"start": 19... | [] | Effect of 1-aminoadamantanes on the MAO activity in brain, liver, and kidney of the rat. In order to elucidate the possible interference of the antiparkinson drug 1-aminoadamantane ( D-1 , PK Merz ) and the antispastic compound 1,3-dimethyl-5-aminoadamantane ( DMAA , D-145 , memantine , Memantine ) on neurotransmitter... | https://pubmed.ncbi.nlm.nih.gov/6891223/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Effect of 1-aminoadamantanes on the MAO activity in brain, liver, and kidney o... |
4a0c95a8282db45a6e5e58d864180a45 | Primary chemotherapy with gemcitabine , liposomal doxorubicin and docetaxel in patients with locally advanced breast cancer : results of a phase I trial . | [
{
"span_id": 0,
"text": "gemcitabine",
"start": 26,
"end": 37,
"token_start": 3,
"token_end": 4
},
{
"span_id": 1,
"text": "doxorubicin",
"start": 50,
"end": 61,
"token_start": 6,
"token_end": 7
},
{
"span_id": 2,
"text": "docetaxel",
"start": 66,
... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | Primary chemotherapy with gemcitabine , liposomal doxorubicin and docetaxel in patients with locally advanced breast cancer : results of a phase I trial . The primary objective was to determine the optimal doses for gemcitabine (prolonged infusion), liposomal doxorubicin (Myocet) and docetaxel as primary (neoadjuvant) ... | https://pubmed.ncbi.nlm.nih.gov/15613900/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Primary chemotherapy with gemcitabine , liposomal doxorubicin and docetaxel in... |
c7bfe36d9357817f952f9c2af200774e | A single bolus of dexamethasone , given before a single large meal , produces a delayed ( 6-hour ) but long-lasting increase in serum leptin ( over 16 hours ) . | [
{
"span_id": 0,
"text": "dexamethasone",
"start": 18,
"end": 31,
"token_start": 4,
"token_end": 5
},
{
"span_id": 1,
"text": "leptin",
"start": 134,
"end": 140,
"token_start": 24,
"token_end": 25
}
] | [] | Effect of one morning meal and a bolus of dexamethasone on 24-hour variation of serum leptin levels in humans. We have previously shown that morning administration of dexamethasone in combination with food induces a doubling of serum leptin levels starting at 7 hours after dexamethasone administration, with a maximum e... | https://pubmed.ncbi.nlm.nih.gov/11068953/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Effect of one morning meal and a bolus of dexamethasone on 24-hour variation o... |
7bcebbcb6a938a791d5b515ab0b481eb | The aim of this single-blind , randomized , controlled trial was to investigate treatment efficacy and safety of aripiprazole as an adjunct to valproic acid ( Ari+Val ) , compared with haloperidol plus valproic acid ( Hal+Val ) , in acute manic patients . | [
{
"span_id": 0,
"text": "aripiprazole",
"start": 113,
"end": 125,
"token_start": 18,
"token_end": 19
},
{
"span_id": 1,
"text": "valproic",
"start": 143,
"end": 151,
"token_start": 23,
"token_end": 24
},
{
"span_id": 2,
"text": "haloperidol",
"star... | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
},
{
"class": "POS",
"spans": [
2,
3
],
"is_context_needed": true
}
] | Combination treatment with aripiprazole and valproic acid for acute mania: an 8-week, single-blind, randomized controlled trial. Despite the fact that combination treatment for patients with acute bipolar is prevalent in clinical practice, the outcomes of adjunct treatment with aripiprazole and a mood stabilizer have r... | https://pubmed.ncbi.nlm.nih.gov/22592508/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Combination treatment with aripiprazole and valproic acid for acute mania: an ... |
634afdc7ed4ee4894a3426d33dc96600 | Because the incidence of nausea and vomiting is significantly reduced when ketorolac is used in place of opioids to attenuate postoperative pain , it would appear to be an appropriate choice of agent to use following propofol anesthesia . | [
{
"span_id": 0,
"text": "ketorolac",
"start": 75,
"end": 84,
"token_start": 11,
"token_end": 12
},
{
"span_id": 1,
"text": "propofol",
"start": 217,
"end": 225,
"token_start": 36,
"token_end": 37
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Ketorolac and propofol administration for prevention of nausea and vomiting in patients undergoing minor gynecologic surgery. This clinical review explores the efficacy of the nonsteroidal antiinflammatory agent, ketorolac tromethamine, added to an anesthetic regimen utilizing intravenous propofol. Both agents have bee... | https://pubmed.ncbi.nlm.nih.gov/8499507/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Ketorolac and propofol administration for prevention of nausea and vomiting in... |
ac00391719a33cac85ce9aa4f853c2d6 | The combination of vandetanib and bicalutamide was associated with considerable toxicity and did not have superior efficacy over bicalutamide alone . | [
{
"span_id": 0,
"text": "vandetanib",
"start": 19,
"end": 29,
"token_start": 3,
"token_end": 4
},
{
"span_id": 1,
"text": "bicalutamide",
"start": 34,
"end": 46,
"token_start": 5,
"token_end": 6
},
{
"span_id": 2,
"text": "bicalutamide",
"start": 1... | [
{
"class": "NEG",
"spans": [
0,
1
],
"is_context_needed": false
}
] | A randomized phase II efficacy and safety study of vandetanib (ZD6474) in combination with bicalutamide versus bicalutamide alone in patients with chemotherapy naïve castration-resistant prostate cancer. To investigate the efficacy and safety of combining vandetanib, an orally available multi-targeted tyrosine kinase i... | https://pubmed.ncbi.nlm.nih.gov/24671507/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A randomized phase II efficacy and safety study of vandetanib (ZD6474) in comb... |
4f1afbea8c1eaa64ea7cb68414fcde1a | Our data indicate that the addition of Aspirin or of Atenolol to Metformin might be beneficial for BC control , and that this activity is likely due to effects on both BC and microenvironment cells . | [
{
"span_id": 0,
"text": "Aspirin",
"start": 39,
"end": 46,
"token_start": 7,
"token_end": 8
},
{
"span_id": 1,
"text": "Atenolol",
"start": 53,
"end": 61,
"token_start": 10,
"token_end": 11
},
{
"span_id": 2,
"text": "Metformin",
"start": 65,
"... | [
{
"class": "POS",
"spans": [
0,
2
],
"is_context_needed": false
},
{
"class": "POS",
"spans": [
1,
2
],
"is_context_needed": false
}
] | Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells. metformin can induce breast cancer (BC) cell apoptosis and reduce BC local and metastatic growth in preclinical models. Since metformin is frequently used along with aspirin or beta-blockers, w... | https://pubmed.ncbi.nlm.nih.gov/26728433/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Aspirin and atenolol enhance metformin activity against breast cancer by targe... |
b0b46e31b844bb0b6f220eb00e3d2031 | Coadministration of vorinostat and oxaliplatin induced G2/M phase arrest , triggered caspase-dependent apoptosis , and decreased tumorigenicity both in vitro and in vivo . | [
{
"span_id": 0,
"text": "vorinostat",
"start": 20,
"end": 30,
"token_start": 2,
"token_end": 3
},
{
"span_id": 1,
"text": "oxaliplatin",
"start": 35,
"end": 46,
"token_start": 4,
"token_end": 5
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": false
}
] | Vorinostat enhances the anticancer effect of oxaliplatin on hepatocellular carcinoma cells. oxaliplatin-based systemic chemotherapy has been proposed to have efficacy in hepatocellular carcinoma (HCC). We investigated the combination of vorinostat and oxaliplatin for possible synergism in HCC cells. SMMC7721, BEL7402, ... | https://pubmed.ncbi.nlm.nih.gov/29239146/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Vorinostat enhances the anticancer effect of oxaliplatin on hepatocellular car... |
3e9de2eafaad5ecdb3048a0e6206a0e1 | Randomized open trial of gentamicin and doxycycline for eradication of Bartonella quintana from blood in patients with chronic bacteremia . | [
{
"span_id": 0,
"text": "gentamicin",
"start": 25,
"end": 35,
"token_start": 4,
"token_end": 5
},
{
"span_id": 1,
"text": "doxycycline",
"start": 40,
"end": 51,
"token_start": 6,
"token_end": 7
}
] | [
{
"class": "POS",
"spans": [
0,
1
],
"is_context_needed": true
}
] | Randomized open trial of gentamicin and doxycycline for eradication of Bartonella quintana from blood in patients with chronic bacteremia . Chronic Bartonella quintana bacteremia is known to occur in homeless people exposed to lice. We present here the results of an open randomized trial performed to evaluate the effic... | https://pubmed.ncbi.nlm.nih.gov/12821469/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Randomized open trial of gentamicin and doxycycline for eradication of Bartone... |
d6a60e2a3810f7b91e415ab7ad060e5d | The role of dual antiplatelet therapy combining aspirin and clopidogrel , is controversial . | [
{
"span_id": 0,
"text": "aspirin",
"start": 48,
"end": 55,
"token_start": 7,
"token_end": 8
},
{
"span_id": 1,
"text": "clopidogrel",
"start": 60,
"end": 71,
"token_start": 9,
"token_end": 10
}
] | [
{
"class": "COMB",
"spans": [
0,
1
],
"is_context_needed": true
}
] | [TREATMENT WITH DUAL ANTIPLATELET THERAPY FOR SECONDARY PREVENTION OF STROKE - PROS AND CONS]. The role of dual antiplatelet therapy combining aspirin and clopidogrel , is controversial . There are two settings in which such treatment might be considered: (a) patients presenting with a first ischemic event at high ris... | https://pubmed.ncbi.nlm.nih.gov/30582310/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
[TREATMENT WITH DUAL ANTIPLATELET THERAPY FOR SECONDARY PREVENTION OF STROKE -... |
ed0f2792fe2d83f42414b3c006dad894 | We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM ( imatinib mesylate , 600 mg/d ) and cytarabine ( 200 mg/d for 7 days ) , followed by hematopoietic stem cell transplantation or maintenance therapy with single-agent IM in patients with MBC-CML at onset or after failure of therapy exclu... | [
{
"span_id": 0,
"text": "daunorubicin",
"start": 40,
"end": 52,
"token_start": 6,
"token_end": 7
},
{
"span_id": 1,
"text": "imatinib",
"start": 85,
"end": 93,
"token_start": 14,
"token_end": 15
},
{
"span_id": 2,
"text": "cytarabine",
"start": 120... | [
{
"class": "POS",
"spans": [
0,
1,
2
],
"is_context_needed": true
}
] | The addition of daunorubicin to imatinib mesylate in combination with cytarabine improves the response rate and the survival of patients with myeloid blast crisis chronic myelogenous leukemia (AFR01 study). The median survival of patients with chronic myelogenous leukemia in myeloid blast crisis (MBC-CML) is poor even ... | https://pubmed.ncbi.nlm.nih.gov/21145590/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
The addition of daunorubicin to imatinib mesylate in combination with cytarabi... |
2ba04bc0fd1492479197971616f7e32b | [ Combination chemo-endocrine therapy of metastatic and stage IV breast cancer with cyclophosphamide , adriamycin , prednisolone and tamoxifen (CAPT)--with special reference to management of brain and liver metastasis ] . | [
{
"span_id": 0,
"text": "cyclophosphamide",
"start": 84,
"end": 100,
"token_start": 12,
"token_end": 13
},
{
"span_id": 1,
"text": "adriamycin",
"start": 103,
"end": 113,
"token_start": 14,
"token_end": 15
},
{
"span_id": 2,
"text": "prednisolone",
... | [
{
"class": "POS",
"spans": [
0,
1,
2,
3
],
"is_context_needed": true
}
] | [ Combination chemo-endocrine therapy of metastatic and stage IV breast cancer with cyclophosphamide , adriamycin , prednisolone and tamoxifen (CAPT)--with special reference to management of brain and liver metastasis ] . Sixty-three evaluable patients with metastatic and stage IV breast cancer who had not previously u... | https://pubmed.ncbi.nlm.nih.gov/2919892/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
[ Combination chemo-endocrine therapy of metastatic and stage IV breast cancer... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.