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6357d2a470758a4d5aea49835ba7b900 | However , we observed significant decreases in the left ventricular mass index and urinary albumin to creatinine ratio in the valsartan group but not in the amlodipine group . | [
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] | [] | Effects of valsartan and amlodipine on home blood pressure and cardiovascular events in Japanese hypertensive patients: a subanalysis of the VART. The valsartan amlodipine Randomized Trial (VART) was performed to compare the beneficial effects of valsartan and amlodipine on cardiovascular events in Japanese hypertensiv... | https://pubmed.ncbi.nlm.nih.gov/21993491/ | ### Instruction:
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3d1bf519d3d919348aa6eab2ae11a2bd | Effects of chloroquine , mefloquine and quinine on natural killer cell activity in vitro . | [
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dd4bbac74556ad8a14b439a38da022bd | Fulvestrant ( intramuscular injection 250 mg month(-1 ) ) was found to be at least as effective as anastrozole ( orally 1 mg day(-1 ) ) for time to progression ( 5.5 vs 4.1 months , respectively ( hazard ratio ( HR ): 0.95 ; 95.14 % confidence interval ( CI ) , 0.82 - 1.10 ; P=0.48 ) ) and objective response 19.2 vs 16... | [
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] | [] | Fulvestrant is an effective and well-tolerated endocrine therapy for postmenopausal women with advanced breast cancer: results from clinical trials. fulvestrant ('Faslodex') is a new type of endocrine treatment--an oestrogen receptor (ER) antagonist that downregulates the ER and has no agonist effects. Early efficacy d... | https://pubmed.ncbi.nlm.nih.gov/15094759/ | ### Instruction:
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267cd5b262efa4d0f40eeeab4d4e304c | Risk factors associated with cardiotoxicity within 2 years of doxorubicin administration included age [ adjusted hazard ratio ( aHR ) = 1.02 , 95 % confidence interval ( CI ) 1.00 - 1.04 ; p = 0.05 ] , metastasis ( aHR = 2.66 ; 95 % CI 1.36 - 5.20 ; p < 0.01 ) , and concomitant trastuzumab ( aHR = 4.08 ; 95 % CI 2.31 -... | [
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9b8558943abd223f38c55dac03ee9082 | Twenty-four patients have been treated to date , and the maximum tolerated dose has been reached at paclitaxel 185 mg/m2 and carboplatin 350 mg/m2 . | [
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] | Preliminary results of a dose-finding study of paclitaxel and carboplatin in patients with advanced non-small cell lung cancer. This ongoing phase I study sought to establish the maximum tolerated dose of the combination of carboplatin and paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) given without ro... | https://pubmed.ncbi.nlm.nih.gov/9007129/ | ### Instruction:
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Preliminary results of a dose-finding study of paclitaxel and carboplatin in p... |
5af37444c8364f62af66ab7987da2456 | FAB M5 was significantly more sensitive than FAB M4 to most drugs frequently used in AML , as indicated by the following ratios of median sensitivities : the anthracyclines ( 2.6- to 3.2-fold ) , mitoxantrone ( 12.5-fold ) , etoposide ( 8.7-fold ) , and cytarabine ( 2.9-fold ) . | [
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Cellular drug resistance profiles in childhood acute myeloid leukemia: differe... |
76f53d15b6627c4c13e14f047a241f67 | [ Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases ] . | [
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[ Aztreonam or gentamicin combined with piperacillin as empiric antibiotic the... |
c8c3eefd188ec9458a1b50c453b92dfb | The present study was undertaken to further elucidate the effect of salbutamol on the pharmacokinetics of digoxin in man . | [
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] | Effect of salbutamol on digoxin pharmacokinetics. A single dose of the beta 2-adrenoceptor agonist salbutamol has previously been shown to decrease serum digoxin concentration in healthy volunteers. A possible explanation of the phenomenon is a beta 2-adrenoceptor-mediated increase in the specific binding of digoxin to... | https://pubmed.ncbi.nlm.nih.gov/1618253/ | ### Instruction:
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Effect of salbutamol on digoxin pharmacokinetics. A single dose of the beta 2-... |
f6650ee92d2f6ba1fb001d64344a260b | Mecamylamine reversed the effects of nicotine on SHR performance . | [
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Nicotine-induced behavioral sensitization in an adult rat model of attention d... |
a2471412eb546f1cfa6a282660907512 | The combination of sub-effective doses of leflunomide and cyclosporin A resulted in significant inhibition of chronic arthritis . | [
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] | Immunomodulation of rat antigen-induced arthritis by leflunomide alone and in combination with cyclosporin A. The effects of the new immunomodulating isoxazol derivative leflunomide, in comparison with cyclosporin A, on established antigen-induced arthritis in rats as well as serum antibody levels were determined. When... | https://pubmed.ncbi.nlm.nih.gov/8907592/ | ### Instruction:
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Immunomodulation of rat antigen-induced arthritis by leflunomide alone and in ... |
bd6411f1a1b7f41d6e10153cd2202962 | In the metastatic setting , FOLFIRINOX ( folinic acid , 5-fluorouracil , irinotecan , and oxaliplatin ) , and nab-paclitaxel plus gemcitabine have yielded only modest improvements in survival . | [
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] | Pancreatic cancer: from state-of-the-art treatments to promising novel therapies. Pancreatic cancer is expected to be the second deadliest malignancy in the USA by 2020. The survival rates for patients with other gastrointestinal malignancies have increased consistently during the past 30 years; unfortunately, however,... | https://pubmed.ncbi.nlm.nih.gov/25824606/ | ### Instruction:
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Pancreatic cancer: from state-of-the-art treatments to promising novel therapi... |
53a14a119d41a911324fb13bb24c206b | Patients in arm 1 ( n = 88 ) received 4 cycles of paclitaxel and carboplatin followed by 2 to 4 cycles of gemcitabine-based combination chemotherapy . | [
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Effects of sequential paclitaxel-carboplatin followed by gemcitabine-based che... |
09afedc0b9034c5961cc31e111f44242 | In patients receiving digoxin and propafenone simultaneously , the SDCs should be monitored and the digoxin dose reduced if there is evidence of toxicity . | [
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] | Interaction between digoxin and propafenone. The pharmacokinetic and pharmacodynamic interactions between digoxin and propafenone were investigated in 10 hospitalized patients with heart disease and cardiac arrhythmias. During steady state (0.25 mg/day) the glycoside was combined with 600 mg of propafenone daily for 1 ... | https://pubmed.ncbi.nlm.nih.gov/2911842/ | ### Instruction:
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Interaction between digoxin and propafenone. The pharmacokinetic and pharmacod... |
f12072676087f8e74c862655cba32504 | To review the clinical effectiveness and cost-effectiveness evidence base for lapatinib ( LAP ) in combination with an aromatase inhibitor ( AI ) and trastuzumab ( TRA ) in combination with an AI for the first-line treatment of patients who have hormone receptor-positive (HR+)/human epidermal growth factor 2-positive (... | [
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Lapatinib and trastuzumab in combination with an aromatase inhibitor for the f... |
5291c1729be9df2b8b65f392854410de | Since combination therapy with nateglinide and vildagliptin restored the decrease in pancreatic beta cell mass , our present findings suggest that combination therapy could be a promising therapeutic strategy for postprandial dysmetabolism associated with obese and insulin resistance . | [
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] | Combination therapy with nateglinide and vildagliptin improves postprandial metabolic derangements in Zucker fatty rats. Postprandial metabolic derangements are one of the risk factors of cardiovascular disease in humans. Insulin resistance and/or impaired early-phase insulin secretion are major determinants of postpra... | https://pubmed.ncbi.nlm.nih.gov/20625970/ | ### Instruction:
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Combination therapy with nateglinide and vildagliptin improves postprandial me... |
e9bc93e6cd607f5ce2ab6d592ba99266 | Paclitaxel , doxorubicin , tamoxifen , erlotinib , gefitinib , temozolomide , and methotrexate are among therapeutic agents whose efficacy is influenced by the expression of H19 . | [
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The role of H19 lncRNA in conferring chemoresistance in cancer cells. H19 is a... |
a28fce0214516827c33a6acc9a87f898 | Patients were randomised to receive either four or eight courses of cytotoxic chemotherapy with cyclophosphamide , vincristine and etoposide and also randomised to receive , on disease progression , either second line chemotherapy ( methotrexate and doxorubicin ) or symptomatic treatment only . | [
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Duration of chemotherapy in small cell lung cancer: a Cancer Research Campaign... |
241b3b811402f79bbd36216dd0287f70 | Amisulpride demonstrated a greater improvement in BPRS total scores ( P<0.05 ) and PANSS negative subscores ( P=0.0001 ) than haloperidol after 12 months of treatment in chronic schizophrenic patients with acute exacerbations . | [
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] | [] | Amisulpride: a review of its efficacy in schizophrenia. To assess the efficacy of the new atypical antipsychotic drug, amisulpride. ### method Studies comparing the efficacy of amisulpride with that of haloperidol and risperidone, respectively, are reviewed. Outcome measures were Clinical Global Impression, Brief Psych... | https://pubmed.ncbi.nlm.nih.gov/10823307/ | ### Instruction:
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Amisulpride: a review of its efficacy in schizophrenia. To assess the efficacy... |
24bf61baac10caa2ceda2cdbe17c973c | In patients with acute cholecystitis , ampicillin plus tobramycin , cefoperazone and piperacillin had clinical cure rates of 85 , 95 and 95 per cent , respectively . | [
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Antibiotics in infections of the biliary tract. The combination of a penicilli... |
03ac9f494ca93f526d5d08ad0531741a | A retrospective analysis of the Phase III trial of pemetrexed versus docetaxel shows a statistically significant longer toxicity-free survival time for pemetrexed compared with docetaxel . | [
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An evaluation of pemetrexed in second-line treatment of non-small cell lung ca... |
f25d84924710d85834c20bd5df3dceea | Tazobactam has inhibitory activity , and therefore protects piperacillin against Richmond and Sykes types II , III , IV and V beta-lactamases , staphylococcal penicillinase and extended-spectrum beta-lactamases . | [
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Piperacillin/tazobactam. A review of its antibacterial activity, pharmacokinet... |
4d7d05a563202fd48c05ee58a0d965ac | The diagnosis was stage IIIA HHV-8-LBL , and he was treated with 6 cycles of R-EPOCH ( rituximab , etoposide , vincristine , doxorubicin , cyclophosphamide , and prednisone ) infusion chemotherapy . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Human Herpesvirus Type 8-associated Large B-cell Lymphoma: A Nonserous Extraca... |
05844fac1ef40cc8323e39504e4af8e5 | Our objective was to define the maximum tolerated dose of an escalating dose of ifosfamide in combination with a fixed dose of doxorubicin supported by granulocyte colony-stimulating factor ( Neupogen ) . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
A phase I study of ifosfamide and doxorubicin with recombinant human granulocy... |
05030f04e3fe94ee28f0a39f5bb787cd | A combined analysis of two pivotal randomized trials of a single dose of pegfilgrastim per chemotherapy cycle and daily Filgrastim in patients with stage II-IV breast cancer . | [
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A combined analysis of two pivotal randomized trials of a single dose of pegfi... |
27c978e08bc33f86686d1c1ae90f631c | [ Nilotinib in patients with chronic myeloid leukemia without response to imatinib ] . | [
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] | [] | [ Nilotinib in patients with chronic myeloid leukemia without response to imatinib ] . Resistance and intolerance to imatinib in patients with chronic myeloid leukemia requires alternative therapies. nilotinib provides a choice as a second-line treatment. The objective of this report was to show the results of a group ... | https://pubmed.ncbi.nlm.nih.gov/24878095/ | ### Instruction:
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[ Nilotinib in patients with chronic myeloid leukemia without response to imat... |
139b9e118c7845a3bd7efe0ae45009ca | At initial treatment with dabrafenib plus trametinib , three patients achieved a partial response and one patient achieved a complete response . | [
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Dabrafenib plus trametinib rechallenge in four melanoma patients who previousl... |
464a6b634dbfb4dee12d8d282b9d21f3 | We performed this meta-analysis to evaluate the clinical efficacy and safety of gemcitabine plus cisplatin ( GP ) and paclitaxel plus cisplatin ( TP ) combined with thermotherapy in the treatment of NSCLC , as well as to provide reference for clinical practice and future research . | [
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] | [Thermo-chemotherapy of GP or TP for advanced non-small cell lung cancer: a systematic review]. Advanced non-small cell lung cancer (NSCLC) is characterized by poor treatment efficacy and short survival time. Clinical trials have shown that the combination of chemotherapy with thermotherapy exhibits strong efficacy. We... | https://pubmed.ncbi.nlm.nih.gov/22901992/ | ### Instruction:
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[Thermo-chemotherapy of GP or TP for advanced non-small cell lung cancer: a sy... |
ae18029f5969f526554b85821e622d76 | The pharmacodynamic effects of ticagrelor were preserved when ticagrelor was given during infusion of cangrelor . | [
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### Input:
Pharmacodynamic effects during the transition between cangrelor and ticagrelor... |
f7d9cb2254b2543d60803eb573a9e7b4 | A 49-year-old woman diagnosed with International Federation of Obstetricians and Gynecologists stage 2018 IIIC2 locally advanced undifferentiated cervical cancer received first-line chemoradiotherapy followed by carboplatin , paclitaxel , and bevacizumab with partial response . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Complete pathological response to olaparib and bevacizumab in advanced cervica... |
73f773b02a672dc89e8413a7261f4848 | Sipuleucel-T , cabazitaxel , abiraterone , enzalutamide and radium-223 have been approved in the pre- or post-docetaxel setting in metastatic CRPC during the last few years . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
SEOM clinical guidelines for the treatment of metastatic prostate cancer. Andr... |
61f05d751c64820a8d80f60bfc98c237 | Therefore , we conducted this phase II study to evaluate the activity and toxicity of the combination paclitaxel and gemcitabine in advanced NSCLC . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
A phase II study of weekly gemcitabine and paclitaxel in patients with previou... |
bfc82b1e67e91b99aeeb487bebe450c3 | Two of these antibodies , cetuximab ( Erbitux ) und bevacizumab ( Avastin ) , directed against the epidermal growth factor receptor ( EGFR ) and the vascular epithelial growth factor ( VEGF ) , respectively , have recently been approved for use in metastatic colorectal cancer . | [
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] | [] | [Antibody treatment in colorectal cancer--what the surgeon needs to know]. Advances in the medical treatment of colorectal cancer patients have resulted in considerable improvements through the introduction of new cytotoxic drugs. The significant progress in molecular and tumour biology has produced a great number of t... | https://pubmed.ncbi.nlm.nih.gov/18415895/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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[Antibody treatment in colorectal cancer--what the surgeon needs to know]. Adv... |
9f0667d430098de87e37d3fd2f9d7e1b | Physically cross-linked beta-lactoglobulin ( BLG ) protein gels containing theophylline and sulfamethoxazole low molecular weight drugs were prepared in 50 % ethanol solution at pH 8 and two protein concentrations ( 6 and 7 % ( w/v ) ) . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Swelling behavior and controlled release of theophylline and sulfamethoxazole ... |
f4921173486b31b67a10b151e4371b72 | Ciprofloxacin , 500 mg orally twice a day plus antifungal prophylaxis , fluconazole 50 mg once daily plus amphotericin B tablets or suspension and tablets , each 200 mg four times a day , was given . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Infection prevention in autologous bone marrow transplantation and the role of... |
f7706f7238a4a6e6e1f27615c9d55119 | In some recently updated clinical guidelines , the fully humanized monoclonal antibody panitumumab , combined with irinotecan , has been recommended as an optional third-line chemotherapy for KRAS wild-type metastatic colorectal cancer ( mCRC ) . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
A Prospective, Multicenter Phase II Study of the Efficacy and Feasibility of 1... |
80434a6ceced9fc5c41ba573025ff686 | A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon ( VEMUPLINT ) in advanced melanoma patients harboring the V600BRAF mutation . | [
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] | A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon ( VEMUPLINT ) in advanced melanoma patients harboring the V600BRAF mutation . Studies carried out in vitro and in a mouse model have shown that BRAF inhibitors enhance the effects of IFN-α on BRAFV600E melanoma cells through the inhibition ... | https://pubmed.ncbi.nlm.nih.gov/33407577/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interfero... |
d89f39f61c1b2844588da47a1cd3c612 | Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with ... |
ce24fba138e6c7a35f02adab371a88f2 | A working group convened by the Centers for Disease Control recommended three antibiotics for the treatment of recurrent and persistent acute otitis media : ( 1 ) amoxicillin/clavulanate in combination with amoxicillin ( high dose amoxicillin regimen , 80 to 90 mg/kg/day ) ; ( 2 ) cefuroxime axetil ( standard dose , 30... | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Recurrent and persistent otitis media. Recurrent acute otitis media occurs dur... |
f0cfa9cab940e4dec4741dc4b6e5231d | On the basis of the estimated costs of infective complications , cefotaxime and ceftriaxone appear equally effective for the prevention of infective complications after abdominal surgery . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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A cost-effectiveness evaluation of 3 antimicrobial regimens for the prevention... |
f05493b65f3c5290a97f09afd7ff253b | The epidermal growth factor receptor tyrosine kinase inhibitors ( EGFR TKIs ) like erlotinib and gefitinib have been extensively studied . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
The role of epidermal growth factor receptor tyrosine kinase inhibitors in the... |
47520d58ca9f3c5271cd5e1b8f17c8d3 | Patients who had failed only one prior chemotherapy regimen and had Eastern Cooperative Oncology Group ( ECOG ) Performance Status ( PS ) ≤2 were randomised to either : pemetrexed 500 mg/m(2 ) on day 1 plus erlotinib 150 mg daily on days 2 - 14 ; erlotinib 150 mg daily ; or pemetrexed 500 mg/m(2 ) on day 1 of a 21-day ... | [
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] | Three-arm randomised controlled phase 2 study comparing pemetrexed and erlotinib to either pemetrexed or erlotinib alone as second-line treatment for never-smokers with non-squamous non-small cell lung cancer. This randomised controlled phase 2 study compared pemetrexed and erlotinib in combination with either agent al... | https://pubmed.ncbi.nlm.nih.gov/23890768/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Three-arm randomised controlled phase 2 study comparing pemetrexed and erlotin... |
099683c01fbf5f8bc5d641f38273f33e | This study was conducted to test the feasibility of reducing the interval between cycles of doxorubicin , cyclophosphamide , etoposide ( ACE ) chemotherapy to 2 weeks , thereby increasing dose intensity , by adding granulocyte colony-stimulating factor ( G-CSF ) to reduce the duration of neutropenia following a cycle . | [
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Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
The feasibility of using glycosylated recombinant human granulocyte colony-sti... |
7f838123add04a29b53b03e5253caefe | The rate of down-stage to pT1 or less was 59 % for methotrexate , vinblastine , doxorubicin and cisplatin , and 53 % for gemcitabine and carboplatin ( P = 0.624 ) . | [
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] | Neoadjuvant gemcitabine plus carboplatin for locally advanced bladder cancer. Although cisplatin-based neoadjuvant chemotherapy followed by cystectomy was demonstrated to improve the survival among patients with locally advanced bladder cancer, its severe adverse events, including nephrotoxicity, are critical issues. W... | https://pubmed.ncbi.nlm.nih.gov/23275643/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Neoadjuvant gemcitabine plus carboplatin for locally advanced bladder cancer. ... |
ad15c6b2de06399a133cb0989bdd489b | The combined irrigation of bupivacaine and ketorolac showed a clinically significant reduction of pain in the first postoperative hour and on postoperative day 5 . | [
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] | The Role of Local Bupivacaine Irrigation in Postoperative Pain Control After Augmentation Mammoplasty: A Systematic Review and Meta-Analysis. The objective of this study is to analyze the efficacy of local bupivacaine irrigation after augmentation mammoplasty for the control of postoperative pain. ### methods A systema... | https://pubmed.ncbi.nlm.nih.gov/29026810/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
The Role of Local Bupivacaine Irrigation in Postoperative Pain Control After A... |
f1d7687091bcc14f1eeb6fad5e6f4ea6 | In group I , clinical response was observed in 10 of 19 febrile episodes ( 52.6 % ) treated with carbenicillin plus gentamicin and in 10 of 14 ( 71.4 % ) treated with latamoxef ( p greater than 0.05 ) . | [
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] | Latamoxef versus carbenicillin plus gentamicin or carbenicillin plus mecillinam in leukopenic, febrile patients with solid tumors. Sixty-six febrile episodes associated with leukopenia were observed in 56 patients with solid tumors, WBC less than 1.5 X 10(9)/l and temperature greater than or equal to 38.5 degrees C. St... | https://pubmed.ncbi.nlm.nih.gov/3535399/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Latamoxef versus carbenicillin plus gentamicin or carbenicillin plus mecillina... |
a719f348c8f180930525ce7b90846d21 | Following lapatinib and trastuzumab , the HER2-E and ERBB2 (HER2-E/ERBB2)-high group showed a higher pCR rate compared to the rest ( 44.5 % , 95 % confidence interval [ CI ] = 35.4 % to 53.9 % vs 11.6 % , 95 % CI = 6.9 % to 18.0 % ; adjusted odds ratio [ OR ] = 6.05 , 95 % CI = 3.10 to 11.80 , P < .001 ) . | [
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] | HER2-Enriched Subtype and ERBB2 Expression in HER2-Positive Breast Cancer Treated with Dual HER2 Blockade. Identification of HER2-positive breast cancers with high anti-HER2 sensitivity could help de-escalate chemotherapy. Here, we tested a clinically applicable RNA-based assay that combines ERBB2 and the HER2-enriched... | https://pubmed.ncbi.nlm.nih.gov/31037288/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
HER2-Enriched Subtype and ERBB2 Expression in HER2-Positive Breast Cancer Trea... |
b99eae8266e0ae323ef5089dd410ba9a | A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model . | [
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] | A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model . Anaplastic thyroid cancer (ATC) is a malignant subtype of thyroid cancers and its mechanism of development remains inconclusive. Importantly, there is no effective strategy for... | https://pubmed.ncbi.nlm.nih.gov/29932104/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Ana... |
ba713428f331bd17d48949c1628f5dc4 | Fingolimod sensitizes EGFR wild‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest . | [
{
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] | Fingolimod sensitizes EGFR wild‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest . Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase and mutations in this gene are major drivers of lung cancer development. EGFR tyrosine kinase inhibitors (TKIs) are standa... | https://pubmed.ncbi.nlm.nih.gov/31059070/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Fingolimod sensitizes EGFR wild‑type non‑small cell lung cancer cells to lapat... |
fc993366438427f4d6964fa73e800a2e | To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone ( GnRH ) agonist triptorelin or the GnRH antagonist cetrorelix . | [
{
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{
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] | [] | Levels of apoptosis in human granulosa cells seem to be comparable after therapy with a gonadotropin-releasing hormone agonist or antagonist. To compare levels of apoptosis in granulosa cells from women treated with the gonadotropin-releasing hormone ( GnRH ) agonist triptorelin or the GnRH antagonist cetrorelix . ###... | https://pubmed.ncbi.nlm.nih.gov/16595220/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Levels of apoptosis in human granulosa cells seem to be comparable after thera... |
20b68079241cd6dc54411493468becf5 | In vitro effects of racemates , separate enantiomers and major metabolites of mefloquine and halofantrine on metoprolol biotransformation by rat liver microsomes . | [
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"start"... | [] | In vitro effects of racemates , separate enantiomers and major metabolites of mefloquine and halofantrine on metoprolol biotransformation by rat liver microsomes . 1. The effects of the anti-malarial drugs mefloquine and halofantrine and of their major metabolites on metoprolol metabolism by rat liver microsomes have b... | https://pubmed.ncbi.nlm.nih.gov/10426558/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
In vitro effects of racemates , separate enantiomers and major metabolites of ... |
5e79090b1a2a1eb6907f90235c5dfb3a | Other studies are evaluating the use of capecitabine , oxaliplatin , and the anti-epidermal growth factor receptor agent cetuximab with RT in this malignancy . | [
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"start": 12... | [] | Current management of anal canal cancer. Squamous cell carcinoma of the anal canal historically has been treated with abdominoperineal resection, resulting in high rates of morbidity and local recurrence. Pioneering work led to the finding that radiation therapy (RT) combined with 5-fluorouracil (5-FU) and mitomycin re... | https://pubmed.ncbi.nlm.nih.gov/19336010/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Current management of anal canal cancer. Squamous cell carcinoma of the anal c... |
c6a3421ac22d4334dd98a5c5dd81e616 | Bacteriological , histopathologic , and clinical outcomes after treatment using moxifloxacin , moxifloxacin and dexamethasone combination , and vancomycin were comparable . | [
{
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{
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] | Effects of intravitreal moxifloxacin and dexamethasone in experimental Staphylococcus aureus endophthalmitis. To evaluate the effects of intravitreal moxifloxacin and moxifloxacin and dexamethasone combination in an experimental rabbit model of Staphylococcus aureus endophthalmitis. ### methods The right eyes of 24 rab... | https://pubmed.ncbi.nlm.nih.gov/17453955/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Effects of intravitreal moxifloxacin and dexamethasone in experimental Staphyl... |
d0abfbca5b519e0900c805ecc3a10c4f | Combining erythromycin , clarithromycin , or azithromycin with rifampin resulted in a significant ( P≤0.005 ) decrease in MPC and MPC/MIC ratio . | [
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] | Mutant prevention concentration and mutant selection window for 10 antimicrobial agents against Rhodococcus equi. The objectives of this study were to determine the mutant prevention concentration (MPC), time above the MPC and mutant selection window for 10 antimicrobial agents against Rhodococcus equi and to determine... | https://pubmed.ncbi.nlm.nih.gov/23915992/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Mutant prevention concentration and mutant selection window for 10 antimicrobi... |
54964251ce7e6cabed1272f0799d82eb | This was confirmed and show that the dCK levels are retained upon co-treatment , indicating a clinical use for bortezomib treatment in combination with cytarabine to avoid development of resistance . | [
{
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{
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] | Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity. The addition of high-dose cytarabine to the treatment of mantle cell lymphoma (MCL) has significantly prolonged survival of patients, but relapses are common and... | https://pubmed.ncbi.nlm.nih.gov/29695239/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Bortezomib prevents cytarabine resistance in MCL, which is characterized by do... |
17ce67b32a1c7321276f9a838007b4ce | Artemether , artesunate , praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis : a comparative in vivo study . | [
{
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{
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... | [] | Artemether , artesunate , praziquantel and tribendimidine administered singly at different dosages against Clonorchis sinensis : a comparative in vivo study . We comparatively assessed the in vivo efficacy of artemether, artesunate, praziquantel and tribendimidine against different stages of Clonorchis sinensis. Rats w... | https://pubmed.ncbi.nlm.nih.gov/18308285/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Artemether , artesunate , praziquantel and tribendimidine administered singly ... |
9fb1ec9eb7a2348ed2fbd8b3bd74a3a0 | The agents studied include : propranolol , timolol , metoprolol , practolol , atenolol and the combined alpha and beta adrenoceptor blocking agent , labetalol . | [
{
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{
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"token_start": 7,
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},
{
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"text": "metoprolol",
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... | [] | Inhibition of purified lysosomal phospholipase A1 by beta-adrenoceptor blockers. Inhibition of rat liver lysosomal phospholipases is one of the main events that leads to accumulation of tissue phospholipids during drug-induced phospholipidosis. Drug inhibition of lysosomal phospholipase A may occur by direct effects of... | https://pubmed.ncbi.nlm.nih.gov/2857566/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Inhibition of purified lysosomal phospholipase A1 by beta-adrenoceptor blocker... |
35618f6c493f9bdf1494b7d89163d65b | Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy , including FoxO1 and its targets . | [
{
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{
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] | [
{
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] | Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy , including FoxO1 and its targets . Fibrates and statins have been widely used to reduce triglyceride and cholesterol levels, respectively. Besides its lipid-lowering effect, the side effect of musc... | https://pubmed.ncbi.nlm.nih.gov/33408297/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Effects of fenofibrate and its combination with lovastatin on the expression o... |
e05d747dfa790c1c8bd20db1d9e43d53 | Idasanutlin was tolerable alone and in combination with cytarabine . | [
{
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{
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] | [
{
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] | Murine double minute 2 inhibition alone or with cytarabine in acute myeloid leukemia: Results from an idasanutlin phase 1/1b study⋆. The prognosis remains poor for patients with relapsed or refractory (r/r) acute myeloid leukemia; thus, novel therapies are needed. We evaluated idasanutlin-a new, potent murine double mi... | https://pubmed.ncbi.nlm.nih.gov/33302031/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Murine double minute 2 inhibition alone or with cytarabine in acute myeloid le... |
276d55d879d554f558d58f254164d21e | Cell surface proteins induced by fludarabine and cladribine may be targets for therapeutic antibodies . | [
{
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{
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"text": "cladribine",
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] | [] | Fludarabine and cladribine induce changes in surface proteins on human B-lymphoid cell lines involved with apoptosis, cell survival, and antitumor immunity. fludarabine and cladribine are purine analogues used to treat hematological malignancies. Alone or in combination with therapeutic antibodies, they are effective i... | https://pubmed.ncbi.nlm.nih.gov/22839105/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Fludarabine and cladribine induce changes in surface proteins on human B-lymph... |
642c1582627371fac3aa51763b0b0fcc | After seven days of chemotherapy with 5-fluorouracil , oxaliplatin and bevacizumab , exploratory surgery revealed a perforation at the ileum . | [
{
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{
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},
{
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"text": "bevacizumab",
"start":... | [
{
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"spans": [
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1,
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] | Intestinal perforation in colorectal cancers treated with bevacizumab (Avastin). bevacizumab is a monoclonal antibody that targets vascular endothelial growth factor (VEGF), and it has shown promise as a clinical agent against metastatic colorectal cancer, and particularly in combination with chemotherapy. Bowel perfor... | https://pubmed.ncbi.nlm.nih.gov/19688063/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Intestinal perforation in colorectal cancers treated with bevacizumab (Avastin... |
b7a74b8f49372a2cf52016dee22d48bd | Nausea graded none or mild 24 h after the start of cisplatin infusion was reported in 71 and 69 % of patients in the 8- and 32-mg ondansetron groups , respectively , and in 73 % of patients in the granisetron group . | [
{
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{
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"start": 130,
"end": 141,
"token_start": 27,
"token_end": 28
},
{
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"text": "granisetron",
"start"... | [
{
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{
"class": "POS",
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] | Ondansetron compared with granisetron in the prophylaxis of cisplatin-induced acute emesis: a multicentre double-blind, randomised, parallel-group study. The Ondansetron and Granisetron Emesis Study Group. This is the first international, multi-centre, double-blind, randomised, parallel group study to directly compare ... | https://pubmed.ncbi.nlm.nih.gov/8265095/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Ondansetron compared with granisetron in the prophylaxis of cisplatin-induced ... |
8797191a6cfcfc6747d63887c0100779 | Relatively recent studies have shown that dexmedetomidine is able to decrease circulating plasma norepinephrine and epinephrine concentration in approximately 50 % , decreases brain blood flow by directly acting on post-synaptic alpha 2 receptors , decreases CSF pressure without ischemic suffering and effectively decre... | [
{
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"text": "dexmedetomidine",
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"end": 57,
"token_start": 6,
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},
{
"span_id": 1,
"text": "epinephrine",
"start": 116,
"end": 127,
"token_start": 15,
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] | [] | Prospective, randomized study to assess the role of dexmedetomidine in patients with supratentorial tumors undergoing craniotomy under general anaesthesia. Preliminary data on the perioperative use of dexmedetomidine in patients undergoing craniotomy for brain tumor under general anaesthesia indicate that the intraoper... | https://pubmed.ncbi.nlm.nih.gov/22428485/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Prospective, randomized study to assess the role of dexmedetomidine in patient... |
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