pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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19,092,695 | Does resistance exercise increase postprandial muscle protein synthesis in humans? | {
"contexts": [
"We examined the impact of an acute bout of resistance-type exercise on mixed muscle protein synthesis in the fed state.",
"After a standardized breakfast, 10 untrained males completed a single, unilateral lower-limb resistance-type exercise session. A primed, continuous infusion of l-[ring-C6... | We conclude that resistance-type exercise performed in a fed state further elevates postprandial muscle protein synthesis rates, which is accompanied by an increase in S6 and 4E-BP1 phosphorylation state. | yes |
19,092,692 | Is exercise capacity in the heat greater in the morning than in the evening in man? | {
"contexts": [
"This study investigated the effect of time of day on endurance exercise capacity in a warm environment.",
"Nine males cycled to exhaustion at 65% .VO2peak in an ambient temperature of 35 degrees C (60% relative humidity) at 0645 h (AM) and 1845 h (PM). Rectal temperature (Tc), skin temperatur... | The results of this study suggest that endurance exercise capacity in the heat was significantly greater in the morning than the evening, possibly due to a lower initial Tc. | yes |
19,109,825 | Do development and validation of a model for prediction of mortality in patients with acute burn injury? | {
"contexts": [
"The objective was to develop a user-friendly model to predict the probability of death from acute burns soon after injury, based on burned surface area, age and presence of inhalation injury.",
"This population-based cohort study included all burned patients admitted to one of the six Belgian... | An accurate model was developed to predict the probability of death from acute burn injury based on simple and objective clinical criteria. | yes |
19,104,789 | Does eNOS T-786C polymorphism affect atorvastatin-induced changes in erythrocyte membrane fluidity? | {
"contexts": [
"Statins have pleiotropic effects, including endothelial nitric oxide synthase (eNOS) upregulation and increased nitric oxide formation, which can be modulated by a genetic polymorphism in the promoter region of the eNOS gene (T-786C). Here, we report our investigation of whether this polymorphism... | These findings suggest that a short treatment with atorvastatin is disadvantageous to subjects with the CC genotype for the T-786C polymorphism compared to those with TT genotype, at least in terms of the hemorheological properties of erythrocytes. | yes |
19,099,528 | Does thrombin induce broad spectrum proteolysis in human serum samples? | {
"contexts": [
"During clotting, a thrombin cleaves fibrinogen releasing fibrinopeptide A (FPA). FPA is easily identified in serum using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). Using MALDI-TOF MS, we observed multiple, progressively shorter fragments of seru... | The resulting peptides indicate broad tolerance beyond the consensus R-G cleavage site of fibrinogen; in fact, there appears to be no bias for the amino acid following the R/K residue. These data support our hypothesis that the enzymatic activities inherent to coagulation, or at least to thrombin, contribute to destabi... | yes |
19,112,060 | Does rapid pressure compensation by automated cuff pressure controllers worsen sealing in tracheal tubes? | {
"contexts": [
"Cyclic redistribution of air within the cuff during respiratory pressure changes creates a self-sealing mechanism which allows tracheal sealing, despite tracheal airway pressure being above baseline cuff inflation pressure. The aim of the present study was to investigate the effect of continuous ... | Automated cuff pressure controllers with rapid pressure correction interfere with the self-sealing mechanism of high sealing HVLP tube cuffs and reduce their improved sealing characteristics. | yes |
19,096,191 | Are anxiety and poor social support independently associated with adverse outcomes in patients with mild heart failure? | {
"contexts": [
"The impact of psychosocial states, such as depression or anxiety, and social support on the outcomes of stable outpatients with mild heart failure (HF) has not been evaluated in the \"real world\" clinical practice.",
"In the present study, 139 patients with a prior history of admission for H... | Anxiety and low social support were independently associated with HF-related re-admission, which indicates the need for their inclusion in the assessment and management of HF. | yes |
19,087,976 | Does plasma from preeclamptic women stimulate transendothelial migration of neutrophils? | {
"contexts": [
"Neutrophils infiltrate systemic vasculature of women with preeclampsia, so we tested the hypothesis that factors in plasma of preeclamptic women activate endothelial cells to produce IL-8 resulting in transendothelial migration of neutrophils. Neutrophil migration was studied using the Transwell ... | Factors present in plasma of preeclamptic women stimulate transendothelial migration of neutrophils which is due to induction of oxidative stress and production of IL-8. | yes |
19,114,898 | Does the thiazolidinedione ciglitazone reduce bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice? | {
"contexts": [
"Thiazolidinediones (TZDs) are synthetic agonists for the peroxisome proliferator-activating receptor-gamma receptor and are currently in use as oral glucose-lowering drugs. TZDs have immune-modulating effects in vitro and in vivo. Because patients with type 2 diabetes have an increased risk for p... | Ciglitazone reduces bacterial outgrowth and local inflammation at least during the early stage of S. pneumoniae pneumonia in mice. | yes |
19,114,896 | Does antishock effect of anisodamine involve a novel pathway for activating alpha7 nicotinic acetylcholine receptor? | {
"contexts": [
"Vagus nerve stimulation inhibits proinflammatory cytokine production by signaling through the alpha7 nicotinic acetylcholine receptor (alpha7nAChR). Anisodamine, a muscarinic acetylcholine receptor antagonist, has been used clinically in China for treatment of various shocks, but the mechanism wa... | These findings demonstrate that the antishock effect of anisodamine is intimately linked to alpha7nAChR-dependent anti-inflammatory pathway. | yes |
19,114,895 | Does alkaline phosphatase treatment improve renal function in severe sepsis or septic shock patients? | {
"contexts": [
"Alkaline phosphatase (AP) attenuates inflammatory responses by lipopolysaccharide detoxification and may prevent organ damage during sepsis. To investigate the effect of AP in patients with severe sepsis or septic shock on acute kidney injury.",
"A multicenter double-blind, randomized, placeb... | In severe sepsis and septic shock, infusion of AP inhibits the upregulation of renal inducible NO synthase, leading to subsequent reduced NO metabolite production, and attenuated tubular enzymuria. This mechanism may account for the observed improvement in renal function. | yes |
19,100,413 | Is loss of renal function associated with deterioration of health-related quality of life in kidney transplant patients? | {
"contexts": [
"The evaluation of health-related quality of life (HRQOL) is becoming an important measure of the outcomes of kidney transplantation. The aim of this study was to evaluate whether deterioration of renal function was associated with a worse HRQOL in kidney transplant patients (KTP) compared with pa... | Our data demonstrated that among KTP deterioration of renal function was associated with a worse HRQOL. | yes |
19,088,639 | Is understanding of anesthesia machine function enhanced with a transparent reality simulation? | {
"contexts": [
"Photorealistic simulations may provide efficient transfer of certain skills to the real system, but by being opaque may fail to encourage deeper learning of the structure and function of the system. Schematic simulations that are more abstract, with less visual fidelity but make system structure ... | Schematic simulations that transparently allow learners to visualize, and explore, underlying system dynamics and relations among components may provide a more effective mental model for certain systems. This may lead to a deeper understanding of how the system works, and therefore, we believe, how to detect and respon... | yes |
19,088,637 | Do medical students learn over distance using virtual reality simulation? | {
"contexts": [
"This article presents the results of a demonstration project that was designed with the goal to determine the feasibility and acceptability of medical students in using distance technology and virtual reality (VR) simulation within a problem-based learning (PBL).",
"This pilot project involve... | These findings suggest the feasibility and acceptability by students in the use of VR simulation integrated into a PBL learning session, as well as multipoint distance technologies that allowed interaction between students and tutors in different locations. The authors believe that these modalities can be applied where... | yes |
19,117,508 | Is neonatal high pressure hydrocephalus associated with elevation of pro-inflammatory cytokines IL-18 and IFNgamma in cerebrospinal fluid? | {
"contexts": [
"In human neonatal high pressure hydrocephalus (HPHC), diffuse white matter injury and gliosis predispose to poor neuro-developmental outcome. The underlying mechanism for diffuse white matter damage in neonatal HPHC is still unclear. Analogous to inflammatory white matter damage after neonatal hy... | Independent of the pathogenesis, neonatal HPHC is associated with the activation of the pro-inflammatory cytokines (IL-18 and IFNgamma) in the CSF, whereas CSF apoptosis biomarkers (sFasL) were unchanged. This suggests that anti-inflammatory treatment (in addition to shunting) could be helpful to preserve cerebral whit... | yes |
19,095,120 | Does laparoscopic improve perioperative outcomes of antireflux surgery at US academic centers? | {
"contexts": [
"Open and laparoscopic antireflux surgeries are standard for the treatment of gastroesophageal reflux disease (GERD). The in-hospital outcomes of laparoscopic and open antireflux procedures were analyzed and compared at US academic medical centers.",
"Using International Classification of Dise... | In the context of US academic centers, approximately three quarters of antireflux procedures are being performed using the laparoscopic approach. These data suggest that laparoscopy has improved in-hospital outcomes when compared with open surgery and is preferred for the surgical treatment of GERD. | yes |
19,105,615 | Do hemangioblasts from human embryonic stem cells generate multilayered blood vessels with functional smooth muscle cells? | {
"contexts": [
"The formation and regeneration of functional vasculatures require both endothelial cells (ECs) and vascular smooth muscle cells (SMCs). Identification and isolation of progenitors with potential for both EC and SMC lineage differentiation from an inexhaustible source, such as human embryonic stem... | These results demonstrate that hemangioblasts (BCs) generated from hESCs are tripotential and can provide a potentially inexhaustible source of cells for the treatment of human blood and vascular diseases. | yes |
19,087,130 | Do foetal 'flat ' bile acids reappear during human liver regeneration after surgery? | {
"contexts": [
"Changes in bile acid (BA) pool, such as the reappearance of typically foetal-type molecular species with a 'flat' structure at the steroid ring, occur during hepatocarcinogenesis, both in humans and rodents. Moreover flat-BAs also appear during rat liver regeneration. These changes can be detecte... | Urinary BA output increases and flat-BAs reappear in urine during human liver regeneration. These results suggest that determination of BAs in urine may be an interesting parameter obtained by non-invasive techniques whose actual clinical value during human liver regeneration warrants further evaluation. | yes |
19,086,262 | Does fluid shear attenuate endothelial pseudopodia formation into the capillary lumen? | {
"contexts": [
"Endothelial cells have the ability to undergo morphological shape changes, including projection of cytoplasmic pseudopodia into the capillary lumen. These cytoplasmic projections significantly influence the hemodynamic resistance to blood flow. To examine mechanotransduction mechanisms, we invest... | The results suggest that there is a mechanism that serves to control cytoplasmic projections in capillary endothelium that is under the control of hemodynamic fluid stress. Investigation of pseudopodia growth on endothelial cells may be significant in understanding capillary obstruction in cardiovascular diseases. | yes |
19,093,916 | Is area-level poverty associated with greater risk of ambulatory-care-sensitive hospitalizations in older breast cancer survivors? | {
"contexts": [
"To estimate the frequency of ambulatory care-sensitive hospitalizations (ACSHs) and to compare the risk of ACSH in breast cancer survivors living in high-poverty with that of those in low-poverty areas.",
"Prospective, multilevel study.",
"National, population-based 1991 to 1999 National ... | Elderly breast cancer survivors who lived in high-poverty census tracts may be at increased risk of reduced posttreatment follow-up care, preventive care, or symptom management as a result of not having adequate, timely, and high-quality ambulatory primary care as suggested by ACSH. | yes |
19,116,038 | Is wSSV ie1 promoter more efficient than CMV promoter to express H5 hemagglutinin from influenza virus in baculovirus as a chicken vaccine? | {
"contexts": [
"The worldwide outbreak of influenza A (H5N1) viruses among poultry species and humans highlighted the need to develop efficacious and safe vaccines based on efficient and scaleable production.",
"White spot syndrome virus (WSSV) immediate-early promoter one (ie1) was shown to be a stronger pr... | The production of H5 HA by baculovirus was enhanced with WSSV ie1 promoter, especially compared with CMV promoter. This contributed to effective elicitation of HA-specific antibody in vaccinated chickens. This study provides an alternative choice for baculovirus based vaccine production. | yes |
19,103,637 | Is the metabolic syndrome amplified in hypothyroid rheumatoid arthritis patients : a cross-sectional study? | {
"contexts": [
"Rheumatoid arthritis (RA) patients are at increased risk of cardiovascular disease (CVD), which is even more pronounced in hypothyroid RA patients. An unfavourable cardiovascular risk profile conferred by a higher prevalence of the metabolic syndrome (MetS) and a higher Framingham risk score migh... | Hypothyroid RA patients, particularly female patients, have a more unfavourable cardiovascular risk profile, reflected by an increased prevalence of the MetS and higher Framingham score, than euthyroid RA patients, suggesting a greater need for cardiovascular risk management in these patients to prevent future CVD even... | yes |
19,116,017 | Are folliculin mutations associated with severe COPD? | {
"contexts": [
"Rare loss-of-function folliculin (FLCN) mutations are the genetic cause of Birt-Hogg-Dubé syndrome, a monogenic disorder characterized by spontaneous pneumothorax, fibrofolliculomas, and kidney tumors. Loss-of-function folliculin mutations have also been described in pedigrees with familial spont... | Genetic variation in folliculin does not appear to be a major risk factor for severe COPD. These data suggest that familial spontaneous pneumothorax and COPD have distinct genetic causes, despite some overlap in radiographic characteristics. | no |
19,101,190 | Does chronic lipoic acid treatment worsen energy imbalances in streptozotocin-induced diabetic rats? | {
"contexts": [
"Our objective was to verify the energy balance in streptozotocin-induced diabetic rats chronically treated with lipoic acid (LA).",
"Diabetes was induced in rats by streptozotocin and the animals divided into four groups, comprising controls and diabetic rats, with each group receiving either... | Our results indicate that chronic treatment with LA aggravates energy imbalances in diabetic animals. Moreover, our data suggest the need to reconsider the use of LA as an adjuvant in the prevention and treatment of type 1 diabetes. | yes |
19,102,418 | Is gastric surgery a risk factor for the development or progression of Barrett 's epithelium? | {
"contexts": [
"Barrett's epithelium is currently believed to be related to acid gastroesophageal reflux. The aim was to determine the role of pancreatic-biliary reflux in the genesis of Barrett's epithelium.",
"The study population comprised 1055 cases (606 men and 449 women; median age, 67 years) who had u... | This lack of association between gastric surgery and Barrett's epithelium suggests that pancreatic-biliary reflux with limited acid is not sufficient for the genesis of Barrett's epithelium. | no |
19,087,565 | Does [ Replacement of androgen receptor gene cause complete androgen insensitivity in a large family ]? | {
"contexts": [
"To confirm the clinical diagnosis of complete androgen insensitivity syndrome (CAIS) by molecular genetic testing in a large family.",
"PCR was performed to amplify the coding region of androgen gene, followed by direct sequencing in the patients with CAIS and relatives in this family.",
... | Mutation Arg773His in the AR gene leads to CAIS in this family. Molecular genetic testing of CAIS facilitates not only prenatal genetic diagnosis but also preimplantation genetic diagnosis and offers genetic counseling for future pregnancies to abandon the transmission of the mutated X chromosome to the coming generati... | yes |
19,102,843 | Does [ Adenovirus-mediated VEGF165 gene transfer have neuroprotective effects in neonatal rats following hypoxic-ischemic brain damage ]? | {
"contexts": [
"To investigate the protective effects of adenovirus-mediated vascular endothelial growth factor (Ad-VEGF)165 gene transfer against hypoxic-ischemic brain damage (HIBD) in neonatal rats.",
"Ad-VEGF recombinant adenovirus was constructed by bacterial homologous recombination technology. Seven-d... | Ad-VEGF gene transfer can increase the expression of VEGF mRNA and VEGF protein, decrease neuronal apoptosis, and increase angiopoiesis in the brain. This attenuates brain damage and improves long-term learning and memory functions in neonatal rats after HIBD. | yes |
19,092,316 | Do daily exercise fluctuations and dietary patterns during training predict visceral fat regain in obese women? | {
"contexts": [
"Visceral adiposity is an essential component of metabolic syndrome. Reduction of excessive visceral fat prevents metabolic syndrome and improves atherosclerotic diseases. This study aimed to identify dietary patterns and physical exercise during the training-education period that predict visceral... | Our results revealed that daily exercise fluctuations and dietary patterns were useful predictors of visceral fat regain. | yes |
19,100,118 | Are [ Hypoxia/reoxygenation-induced increased activity and expression of PTP-1B in neonatal rat cardiomyocytes mediated by nitric oxide ]? | {
"contexts": [
"To explore if the hypoxia/reoxygenation-induced increased activity and expression of PTP-1B in neonatal rat cardiomyocytes are mediated by nitric oxide (NO).",
"Neonatal rat cardiomyocytes were isolated and randomly divided into 4 groups: normal group (N group); hypoxia/reoxygenation group (H... | This study showed that pretreatment with L-NAME, a non-selective inhibitor of NOS, prevented the hypoxia/reoxygenation-induced increase in PTP-1B activity and expression in cardiomyocytes, suggesting PTP-1B activation during hypoxia/reoxygenation was mediated by nitric oxide. | yes |
19,097,964 | Does ultrasonic cardiac output monitor provide accurate measurement of cardiac output in recipients after liver transplantation? | {
"contexts": [
"The ultrasonic cardiac output monitor (USCOM; USCOM Pty. Ltd., Sydney, NSW, Australia) has been accepted as a noninvasive device for measuring cardiac function in various clinical conditions. The present study aimed at comparing the accuracy of this device with that of the thermodilution techniqu... | This is the first study to evaluate the accuracy of USCOM in the post-liver transplant setting. This device is accurate in measuring CO in liver transplant recipients postoperatively. Possible risks of arrhythmia, infection and pulmonary artery rupture can be avoided because of its noninvasive nature. USCOM should be c... | yes |
19,097,962 | Does propofol infusion shorten and attenuates oxidative stress during one lung ventilation? | {
"contexts": [
"Resuming two lung ventilation (2LV) from one lung ventilation (OLV) has been proven to induce significant oxidative stress, mainly by superoxide release. Although total intravenous anesthesia and inhalational anesthesia are both used in thoracic surgery, different anesthetics may alter the oxidan... | Propofol infusion, compared with isoflurane inhalation, attenuates ROS production and limits it for 20 minutes after resuming 2LV from OLV. Propofol infusion may be beneficial to patients with inadequate antioxidant capacity. | yes |
19,100,095 | Does [ Erythropoietin suppress the expressions of TGF-beta1 and collagen in rat cardiac fibroblasts induced by angiotensin II ]? | {
"contexts": [
"Recent studies have shown cardiac protection effects of erythropoietin (EPO). The present experiment was designed to investigate the effects of EPO on TGF-beta1, nitric oxide synthase (NOS), collagen contents induced by angiotensin II (Ang II) in rat cardiac fibroblasts (CFs) and explore the role... | EPO suppresses the upregulated expressions of TGF-beta1 and increased production of collagen induced by Ang II through activating the PI3-K/Akt signaling pathway in neonatal rat CFs. | yes |
19,105,964 | Does hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuate mucosal inflammation during intestinal hypoxia? | {
"contexts": [
"The surface of the intestinal mucosa is particularly prone to hypoxia-induced inflammation. Previous studies implicated signaling via extracellular adenosine in endogenous attenuation of intestinal inflammation; we investigated whether epithelial adenosine transport could reduce hypoxia-induced i... | HIF-1alpha-dependent repression of ENT2 increases mucosal adenosine signaling and attenuates hypoxia-associated inflammation of the intestine. | yes |
19,106,904 | Does [ Atopic dermatitis aggravate the allergic airways inflammation in acute viral bronchiolitis ]? | {
"contexts": [
"Exhaled nitric oxide (FeNO) is a putative non-invasive marker of eosinophilic airway inflammation with a good predictive value for allergic asthma in preschool children. The aim of the present study was to compare FeNO after acute viral bronchiolitis (AVB) in children aged less than 2 years witho... | Atopic children below 2 years with AD produce more NO after AVB than non-atopic children or atopic children without any history of AVB. Maternal feeding decreases FeNO. | yes |
19,088,851 | Are distinct determinants in HIV-1 Vif and human APOBEC3 proteins required for the suppression of diverse host anti-viral proteins? | {
"contexts": [
"APOBEC3G (A3G) and related cytidine deaminases of the APOBEC3 family of proteins are potent inhibitors of many retroviruses, including HIV-1. Formation of infectious HIV-1 requires the suppression of multiple cytidine deaminases by Vif. HIV-1 Vif suppresses various APOBEC3 proteins through the co... | Our data suggest that distinct regions of A3F and A3G are targeted by HIV-1 Vif molecules. However, HIV-1 Vif suppresses A3F, A3C, and A3DE through similar recognition determinants, which are conserved among Vif molecules from diverse HIV-1 strains. Mapping these determinants may be useful for the design of novel anti-... | yes |
19,114,944 | Do quality of life assessment as the treatment outcome evaluation of war torture survivors according to gender? | {
"contexts": [
"The objective is the evaluation of treatment outcome difference between men and women through measuring quality of life persons who experienced war torture in Bosnia and Herzegovina.",
"The research is analytical-descriptive and retrospective. It was conducted at two samples which were homoge... | Generally, the quality of life results, both men and women war torture survivors are representing the evaluation of treatment outcome, justifying fully purpose of this treatment type. | yes |
19,100,603 | Does chronic periglandular inflammation on prostate needle biopsy increase the likelihood of cancer on subsequent biopsy? | {
"contexts": [
"Recent literature suggests a role for chronic inflammation in the development of prostate cancer. We investigated the association of chronic periglandular inflammation on prostate needle biopsy with subsequent prostate cancer development and clinical disease features at presentation.",
"Six h... | Although inflammation on initial and subsequent biopsy does not predict prostate cancer in this cohort, we cannot dismiss its role in prostate cancer pathogenesis. Additional research is necessary to explore the relationship between prostate inflammation and prostate cancer development. | no |
19,106,266 | Does recombinant human thyrotropin enhance endothelial-mediated vasodilation of conduit arteries? | {
"contexts": [
"Endothelial cells possess receptors to TSH. Their role is largely unknown.",
"The objective of the study was to determine whether elevated serum TSH levels, as occur in hypothyroidism, affect endothelial function of large arteries and vascular risk biomarkers.",
"Thirty-four consecutively... | rhTSH causes marked and persistent activation of the endothelial mediated vasodilation, independent of systemic hemodynamic changes. | yes |
19,101,069 | Is beta-catenin involved in N-cadherin-dependent adhesion , but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells? | {
"contexts": [
"The t(1;19)(q23;13) translocation, resulting in the production of the E2A-PBX1 chimeric protein, is a common nonrandom translocation in pediatric B-lineage acute lymphoblastic leukemia (B-ALL). The E2A-PBX1 chimeric protein activates expression of several genes, including Wnt16. In the present st... | Wnt16 does not activate canonical Wnt signaling in E2A-PBX1-positive cells. Instead, beta-catenin is involved in N-cadherin-dependent adherence junctions, suggesting for the first time that leukemia-stroma interactions may be mediated via an N-cadherin-dependent mechanism. | yes |
19,111,020 | Is the pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin expressed in human Kupffer cells and regulated by PU.1? | {
"contexts": [
"Human LSECtin (liver and lymph node sinusoidal endothelial cell C-type lectin, CLEC4G) is a C-type lectin encoded within the L-SIGN/DC-SIGN/CD23 gene cluster. LSECtin acts as a pathogen attachment factor for Ebolavirus and the SARS coronavirus, and its expression can be induced by interleukin-4 o... | LSECtin is expressed by liver myeloid cells, and its expression is dependent on the PU.1 transcription factor. | yes |
19,097,861 | Is reduced fronto-temporal connectivity associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia? | {
"contexts": [
"A \"disconnectivity model\" of schizophrenia has been proposed, but it is still unclear if white matter abnormalities are associated with gray matter changes and if they may be the anatomic substrate of cognitive impairment, which is a core symptom of the disorder. The first objective was to dete... | Our data support the disconnectivity hypothesis in schizophrenia, enlightening a link between reduced fronto-temporal connectivity and "frontal" cognitive deficits. Reduced gray matter density may be involved primarily in the pathogenesis of some of these disconnected areas. | yes |
19,086,911 | Is weight increase associated with skeletal muscle immunostaining for advanced glycation end products , receptor for advanced glycation end products , and oxidation injury? | {
"contexts": [
"Tissue accumulation of advanced glycation end products (AGEs) is associated with ageing, both in diabetics and nondiabetic subjects.",
"The purpose of this study was to assess immunostaining for AGEs, specifically carboxymethyl-lysine (CML) and receptor for AGEs (RAGE), in muscle tissue of he... | The increase of skeletal muscle AGEs/RAGE and markers of inflammation and oxidative injury in association with weight gain and old age suggest a pathogenic role of AGEs in weight gain and in sarcopenia of aging. | yes |
19,091,090 | Are genetic polymorphisms associated with serum levels of sex hormone binding globulin in postmenopausal women? | {
"contexts": [
"Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues. The objective of this study was to analyze the influence of common polymorphisms of the SHBG gene on serum SHBG, bone... | Some common genetic variants of the SHBG gene, and particularly an A/G polymorphism situated in the 5' region, influence serum SHBG levels. However, a significant association with BMD or osteoporotic fractures has not been demonstrated. | yes |
19,117,409 | Do albumin-based or albumin-linked calibrators cause a positive bias in serum proteins assayed by the biuret method? | {
"contexts": [
"Assay of total serum protein by the biuret method calibrated with albumin standards according to the reference method provides results with a positive bias approximately 3%-5% exceeding the total error of 3.4% allowable for total protein in serum analysis made by analysers using two-part reagents... | Standard Reference Material 927c based on pure bovine albumin is still recommended and used as the primary standard for assays of total protein by colourimetric methods. The albumin calibrator is responsible for a positive bias of approximately 3%-5% in serum total protein assayed by the biuret reaction both in the ref... | yes |
19,089,771 | Does lysophosphatidylcholine induce endothelial cell injury by nitric oxide production through oxidative stress? | {
"contexts": [
"To determine whether lysophosphatidylcholine (LPC) induces endothelial cell injury by altering the production of nitric oxide (NO) and thereby increasing reactive oxygen species (ROS).",
"Human umbilical vein endothelial cells (HUVECs) were cultured and exposed to LPC, LPC with N(G)-nitro-l-a... | These findings suggest that LPC induces the overproduction of NO, which may increase the oxidative stress on endothelial cells and lead to endothelial cell injury. | yes |
19,114,881 | Does systemic use of the endolysin Cpl-1 rescue mice with fatal pneumococcal pneumonia? | {
"contexts": [
"Community-acquired pneumonia is a very common infectious disease associated with significant morbidity and mortality. Streptococcus pneumoniae is the predominant pathogen in this disease, and pneumococcal resistance to multiple antibiotics is increasing. The recently purified bacteriophage endoly... | Cpl-1 may provide a new therapeutic option in the treatment of pneumococcal pneumonia. | yes |
19,114,886 | Do dynamic preload indicators fail to predict fluid responsiveness in open-chest conditions? | {
"contexts": [
"Dynamic preload indicators like pulse pressure variation (PPV) and stroke volume variation (SVV) are increasingly being used for optimizing cardiac preload since they have been demonstrated to predict fluid responsiveness in a variety of perioperative settings. However, in open-chest conditions, ... | Our results suggest that the dynamic preload indicators PPV and SVV are able to predict fluid responsiveness under closed-chest conditions, whereas all static and dynamic preload indicators fail to predict fluid responsiveness under open-chest conditions. | yes |
19,116,652 | Is opposing effects of sirtuins on neuronal survival : SIRT1-mediated neuroprotection independent of its deacetylase activity? | {
"contexts": [
"Growing evidence suggests that sirtuins, a family of seven distinct NAD-dependent enzymes, are involved in the regulation of neuronal survival. Indeed, SIRT1 has been reported to protect against neuronal death, while SIRT2 promotes neurodegeneration. The effect of SIRTs 3-7 on the regulation of n... | Overall, our study makes three contributions - (a) it represents the first analysis of SIRT3-7 in the regulation of neuronal survival, (b) it shows that neuroprotection by SIRT1 can be mediated by a novel, non-catalytic mechanism, and (c) that subcellular localization may be an important determinant in the effect of SI... | yes |
19,117,035 | Does galactomannan serve as a surrogate endpoint for outcome of pulmonary invasive aspergillosis in neutropenic hematology patients? | {
"contexts": [
"A noninvasive, objective, reproducible, and quantitative Aspergillus-specific surrogate marker is needed for a more accurate assessment of the outcome of invasive aspergillosis (IA) in patients with a hematologic disorder. The quantitative serum galactomannan index (GMI) assay seems to fulfill th... | In neutropenic patients with seropositive IA, serum galactomannan index outcome strongly correlates with survival, autopsy findings, and response outcome. This finding may have implications for patient management and for clinical trial design. | yes |
19,117,039 | Are twenty-four-month postradiation prostate biopsies strongly predictive of 7-year disease-free survival : results from a Canadian randomized trial? | {
"contexts": [
"The objective of this study was to evaluate the predictive value of prostate biopsies that were obtained 24 months after the completion of radiotherapy (RT) with respect to disease-free survival (DFS) in a randomized trial that compared 3 months versus 8 months of neoadjuvant hormone therapy befo... | Two-year post-RT prostate biopsies were strongly predictive of subsequent DFS. Biopsies with severe treatment effect were considered negative. | yes |
19,094,670 | Do [ Evaluation of efficacy and safety on steroid withdraw at the seventh day after liver transplantation ]? | {
"contexts": [
"To evaluate efficacy and safety on steroid withdrawal at the seventh day after liver transplantation.",
"Seventy-six adult patients undergoing first cadaveric liver transplantation from October 2005 to October 2007 were randomly divided into 7 day (n = 40) and 3 month (n = 36) steroid withdra... | Steroid withdrawal strategy at day 7 is same safety and efficacy as steroid withdrawal at 3 month. | yes |
19,107,500 | Are high mean platelet volume , low-grade systemic coagulation and fibrinolytic activation associated with androgen and insulin levels in polycystic ovary syndrome? | {
"contexts": [
"The present study was designed to determine (a) the coagulation parameters, WBC and MPV levels; (b) whether there was any association between androgen and mean platelet volume and low-grade systemic coagulation in PCOS patients.",
"A total of 48 patients with non-diabetic PCOS were studied in... | PCOS patients had low-grade systemic coagulation and fibrinolytic activation as evidenced by elevated D-dimer, and increased WBC and MPV levels suggesting that hematological parameters could potentially be used as indicators of risk factor for atherosclerosis in PCOS women. | yes |
19,093,925 | Are overweight and obesity in old age associated with greater dementia risk? | {
"contexts": [
"To describe the association between body mass index (BMI) and dementia risk in older persons.",
"Prospective population-based study, with 8 years of follow-up.",
"The municipality of Lieto, Finland, 1990/91 and 1998/99.",
"Six hundred five men and women without dementia aged 65 to 92 ... | Older persons with higher BMI scores have less dementia risk than their counterparts with lower BMI scores. High BMI scores in late life should not necessarily be considered to be a risk factor for dementia. | no |
19,093,924 | Do neutrophils of centenarians show function levels similar to those of young adults? | {
"contexts": [
"To analyze several functions and antioxidant parameters of peripheral blood neutrophils from healthy centenarians (men and women) and compare them with those of healthy young (aged 25-35) and middle-aged (aged 65-75) men and women.",
"Cross-sectional study.",
"Community-based.",
"Twen... | Progressive impairment of the immune system accompanies aging. The better preservation of function and antioxidant systems in the neutrophils of centenarians could play a key role in the longevity of these subjects. | yes |
19,109,543 | Is arm use after left or right hemiparesis influenced by hand preference? | {
"contexts": [
"Despite strong evidence for hand preference and its impact on motor performance, its influence on stroke rehabilitation has not been routinely considered. Previous research demonstrates that patients with hemiparetic stroke use their ipsilesional, nonparetic arm 5 to 6 times more frequently than ... | These findings emphasize the influence of hand preference on arm use after stroke for the ipsilesional but not the contralesional arm. Although both stroke groups used their ipsilesional more than their contralesional arm, the difference was greater for the right hemisphere damage group who used their ipsilesional arm ... | yes |
19,109,541 | Does microarray RNA expression analysis of cerebral white matter lesions reveal changes in multiple functional pathways? | {
"contexts": [
"White matter lesions (WML) in brain aging are linked to dementia and depression. Ischemia contributes to their pathogenesis but other mechanisms may contribute. We used RNA microarray analysis with functional pathway grouping as an unbiased approach to investigate evidence for additional pathogen... | WML represent areas with a complex molecular phenotype. From this and previous evidence, WML may arise through tissue ischemia but may also reflect the contribution of additional factors like blood-brain barrier dysfunction. Differential expression of genes in WM[L] compared to WM[C] indicate a "field effect" in the se... | yes |
19,094,147 | Do adult protective services use for older adults at the time of hospital discharge? | {
"contexts": [
"In this article a description is given of the use of adult protective services (APS) as a \"safety net\" by healthcare team members (HCTMs) when concerns were evident about an older adult's hospital discharge decisions.",
"The study had a descriptive qualitative design and participants' perce... | The APS system does not augment, nor does it replace, adequate hospital discharge planning. The use of the APS system as a safety net at the time of hospital discharge is a symptom of a grave problem that will only worsen as the number of elderly adults increases and adds stress to an already overburdened healthcare sy... | yes |
19,095,135 | Is nonmyocardial production of ST2 protein in human hypertrophy and failure related to diastolic load? | {
"contexts": [
"This study was designed to investigate: 1) relationships between serum ST2 levels and hemodynamic/neurohormonal variables; 2) myocardial ST2 production; and the 3) expression of ST2, membrane-anchored ST2L, and its ligand, interleukin (IL)-33, in myocardium, endothelium, and leukocytes from patie... | In human hypertrophy and failure, serum ST2 correlates with the diastolic load. Though the heart, endothelium, and leukocytes express components of ST2/ST2L/IL-33 pathway, the source of circulating serum ST2 is extra-myocardial. | yes |
19,112,839 | Is [ Islet isolation outcome influenced by pancreas preparation method ]? | {
"contexts": [
"Pancreatic islet transplantation is a treatment method for type I diabetes. Its outcome is influenced by numerous factors, islet quantity and function being important ones of them.",
"was to estimate the influence of pancreas preparation method on the outcome of islet isolation in rat.",
... | Pancreas preparation method is one of which influences on islet isolation outcome. | yes |
19,102,374 | Does serum alpha-fetoprotein level per tumor volume reflect prognosis in patients with hepatocellular carcinoma after curative hepatectomy? | {
"contexts": [
"The clinical usefulness of alpha-fetoprotein (AFP) in the management of hepatocellular carcinoma (HCC) remains controversial. This study aimed to assess the prognostic reliability of serum AFP levels per tumor volume (AFP/volume) after curative resection.",
"A total of 196 patients with HCC w... | AFP/volume represents a better prognostic indicator for patients with HCC than serum AFP value alone. In particular, patients with AFP/volume > 20.0 are likely to experience recurrence within 6 months after curative hepatectomy. | yes |
19,091,886 | Does a new PET scanner with semiconductor detectors enable better identification of intratumoral inhomogeneity? | {
"contexts": [
"An autoradiography method revealed intratumoral inhomogeneity in various solid tumors. It is becoming increasingly important to estimate intratumoral inhomogeneity. However, with low spatial resolution and high scatter noise, it is difficult to detect intratumoral inhomogeneity in clinical settin... | These phantom and clinical studies suggested that this new PET scanner has the potential for better identification of intratumoral inhomogeneity, probably because of its high spatial resolution and low scatter noise. | yes |
19,090,590 | Does partial bladder outlet obstruction reduce the tissue antioxidant capacity and muscle nerve density of the guinea pig bladder? | {
"contexts": [
"Reactive nitrogen and oxygen species (RNOS) likely play a role in the development of bladder dysfunction related to bladder outlet obstruction. Antioxidants protect against these free radicals. The aim of our study was to investigate the effect of bladder outlet obstruction on the endogenous anti... | This study demonstrates that the antioxidant status of guinea pig bladders exposed to outlet obstruction decreased which might be associated with the observed reduction in nerve density. The results strengthen the hypothesis that oxidative stress is involved in the pathophysiology of bladder dysfunction related to obst... | yes |
19,111,481 | Does whole genome-expression profiling reveal a role for immune and inflammatory response in abdominal aortic aneurysm rupture? | {
"contexts": [
"This study used the whole transcriptome approach to investigate the role of genes involved in immune and inflammatory response at the site of aneurysm rupture.",
"Rupture site and paired anterior sac biopsies (internal control) of ruptured abdominal aortic aneurysms (AAAs) (n=10) were analyse... | The differential expression of genes involved in immune and inflammatory responses was confirmed at AAA rupture site. These genes may represent novel targets for treatment of aneurysms. | yes |
19,092,235 | Does increased insulin sensitivity by metformin enhance intense-pulsed-light-assisted hair removal in patients with polycystic ovary syndrome? | {
"contexts": [
"Polycystic ovary syndrome (PCOS) is an insulin-resistant state with hirsutism as a common manifestation.",
"We hypothesized that treatment with metformin would improve the cosmetic effects of intense pulsed light (IPL) therapy for hair removal in PCOS patients.",
"In a prospective randomi... | Adding metformin to IPL in women with PCOS results in a significant improvement in insulin sensitivity and hirsutism. | yes |
19,116,006 | Does gene expression meta-analysis identify metastatic pathways and transcription factors in breast cancer? | {
"contexts": [
"Metastasis is believed to progress in several steps including different pathways but the determination and understanding of these mechanisms is still fragmentary. Microarray analysis of gene expression patterns in breast tumors has been used to predict outcome in recent studies. Besides classific... | By pathway meta-analysis many biological mechanisms beyond major characteristics such as proliferation are identified. Transcription factor analysis identifies a number of key factors that support central pathways. Several previously proposed treatment targets are identified and several new pathways that may constitute... | yes |
19,088,444 | Does reduced calmodulin expression accelerate transient outward potassium current inactivation in diabetic rat heart? | {
"contexts": [
"In myocytes from diabetic hearts, the reduction in the amplitude of the transient outward potassium current (I(to)) and the acceleration of its inactivation contribute to the action potential duration lengthening. Whereas the reduced amplitude is attributable to a reduced support of trophic facto... | Diabetes-induced acceleration of I(to) current inactivation is due to a reduced effect of CaMKII on I(to) channels as a result of a diabetes-induced reduction in calmodulin protein expression. A correct follow up of the insulin treatment could prevent this alteration. | yes |
19,108,751 | Do macrophage-secreted factors enhance the in vitro expansion of DMD muscle precursor cells while preserving their myogenic potential? | {
"contexts": [
"Autologous cell transplantation has been proposed as a possible therapeutic approach for Duchenne dystrophy. In this approach, patients' muscle precursor cells (mpcs) obtained from muscle biopsies would be expanded ex vivo, genetically modified to restore dystrophin expression and then reimplante... | Using macrophagic factors, we were able to increase the amount of DMD-mpcs obtainable after 38 days of culture by >7 x 10(3)-fold. These findings indicate that macrophagic factors hold great potential for future use in cell transplantation protocol. | yes |
19,108,754 | Is early post-ischemic hyperemia on transcranial cerebral oxygen saturation monitoring in carotid endarterectomy associated with severity of cerebral ischemic insult during carotid artery clamping? | {
"contexts": [
"In animal models, the magnitude of early post-ischemic hyperemia tends to correlate with the duration and intensity of prior ischemic insult. The aim of this study was to determine whether early post-ischemic hyperemia in human brain during carotid endarterectomy (CEA) is associated with the seve... | Early post-ischemic hyperemia in CEA is correlated with the severity of cerebral ischemic insult during clamping of the ICA. | yes |
19,101,587 | Is television news exposure related to fear of breast cancer? | {
"contexts": [
"This study assessed the relationship between exposure to breast cancer content in television news programs and fear of breast cancer.",
"A quantitative standardized Health and Media Interview Survey was administered to a random sample of 500 Flemish women aged 18-85 years in 2007. The survey ... | These results suggest a relationship between exposure to breast cancer coverage in television news programs and fear of breast cancer. | yes |
19,106,798 | Is velocity propagation of early diastole a valuable tool for left ventricular remodelling after the first myocardial infarction? | {
"contexts": [
"Velocity propagation (Vp) of early diastole is a known method for the evaluation of left ventricular (LV) diastolic function. Our purpose was to determine whether Vp is a valuable tool to characterize patients after acute myocardial infarction and LV remodelling (LVR).",
"M-mode, two-dimensio... | In this study, Vp was the only valuable Doppler echocardiographic tool that reflected early LVR and LLVR. | yes |
19,092,626 | Is after an episode of acute low back pain , recurrence unpredictable and not as common as previously thought? | {
"contexts": [
"Inception cohort study.",
"To provide the first reliable estimate of the 1-year incidence of recurrence in subjects recently recovered from acute nonspecific low back pain (LBP) and to determine factors predictive of recurrence in 1 year.",
"Previous studies provide potentially flawed est... | This study challenges the assumption that the majority of subjects will have a recurrence of LBP in a 1-year period. After the resolution of an episode of acute LBP, about 25% of subjects will have a recurrence in the next year. It is difficult to predict who will have a recurrence within the next year. | yes |
19,108,017 | Is prevalence of Foxp3 positive T regulatory cells increased during progression of cutaneous squamous tumors? | {
"contexts": [
"Forkhead box p3 (Foxp3) positive T regulatory cells (Tregs) have a functionally immunosuppressive property that prevents effector cells from acting against self in autoimmune diseases or a tumor. It is known that Tregs may be highly relevant in cancer progression. Dendritic cells (DCs) induce cut... | Tregs is related to cutaneous squamous tumor progression. | yes |
19,087,283 | Do molecular phylogenetics reveal multiple tertiary vicariance origins of the African rain forest trees? | {
"contexts": [
"Tropical rain forests are the most diverse terrestrial ecosystems on the planet. How this diversity evolved remains largely unexplained. In Africa, rain forests are situated in two geographically isolated regions: the West-Central Guineo-Congolian region and the coastal and montane regions of Eas... | Molecular phylogenetic dating analyses of this large pan-African clade of Annonaceae unravels an interesting pattern of diversification for rain forest restricted trees co-occurring in West/Central and East African rain forests. Our results suggest that repeated reconnections between the West/Central and East African r... | yes |
19,109,214 | Is cD56 expression in T-cell acute lymphoblastic leukemia associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy? | {
"contexts": [
"Expression of CD56 has been associated with poor prognosis in acute myeloid leukemia and aggressive lymphoma.",
"We analyzed the impact of CD56 expression in a cohort of 452 newly diagnosed adult T-cell acute lymphoblastic leukemia (T-ALL) patients; clinical data were available for 306 patien... | CD56 is expressed on a subset of adult T-ALL with distinct immunophenotypical features and higher resistance to therapy. Most CD56(+) ALL were treated in the high-risk arm of the GMALL study protocols owing to their non-thymic phenotype. Thus after risk adapted treatment a prognostic impact of CD56 expression was not d... | yes |
19,087,125 | Do echo Doppler parameters predict response to cardiac resynchronization therapy? | {
"contexts": [
"Cardiac resynchronization therapy (CRT) has been shown to reduce heart failure related morbidity and mortality. However, approximately 30% of patients do not respond to CRT. We investigated the usefulness of Echo Doppler parameters to predict reverse remodelling, functional improvement and mortal... | The QED and IVMD predict reverse remodelling and survival following CRT. These parameters are easy to obtain, provide valuable prognostic information, and should thus be measured in CRT candidates evaluated by echocardiography. | yes |
19,107,196 | Does porphyrin homeostasis maintained by ABCG2 regulate self-renewal of embryonic stem cells? | {
"contexts": [
"Under appropriate culture conditions, undifferentiated embryonic stem (ES) cells can undergo multiple self-renewal cycles without loss of pluripotency suggesting they must be equipped with specific defense mechanisms to ensure sufficient genetic stability during self-renewal expansion. The ATP bi... | The present work demonstrated that ABCG2 protects ES cells from PPIX accumulation during colony expansion, and that p53 and gammaH2AX acts as a downstream checkpoint of ABCG2-dependent defense machinery in order to maintain the self-renewal of ES cells. | yes |
19,108,937 | Does butyrate modulate oxidative stress in the colonic mucosa of healthy humans? | {
"contexts": [
"Butyrate, a short-chain fatty acid produced by colonic microbial fermentation of undigested carbohydrates, has been implicated in the maintenance of colonic health. This study evaluates whether butyrate plays a role in oxidative stress in the healthy colonic mucosa.",
"A randomized, double bl... | This study demonstrated that butyrate is able to beneficially affect oxidative stress in the healthy human colon. | yes |
19,114,959 | Does capsaicin block HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine pulmonary arteries? | {
"contexts": [
"Highly active antiretroviral therapy (HAART) including HIV protease inhibitor ritonavir may be associated with the clinical complications including accelerated atherosclerosis and pulmonary artery hypertension. The objective of this study was to determine whether capsaicin, a major ingredient of ... | Capsaicin effectively inhibits the detrimental effects of HIV protease inhibitor ritonavir on vasomotor functions of porcine pulmonary arteries. These findings may suggest that capsaicin could have clinical applications to prevent vascular and pulmonary complications of HAART drugs in HIV patients. | yes |
19,116,942 | Does early insulin secretion failure lead to diabetes in Chinese subjects with impaired glucose regulation? | {
"contexts": [
"Both beta-cell dysfunction and decreased insulin sensitivity are involved in the pathogenesis of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), while their relative contribution in the progression to type 2 diabetes still remains controversial. The aim of the present study i... | Failure of beta-cell function might be the main reason for both IGT and IFG developing into diabetes instead of aggravated insulin resistance. | yes |
19,100,537 | Does human papillomavirus found in sperm head of young adult males affect the progressive motility? | {
"contexts": [
"To evaluate the prevalence of human papillomavirus (HPV) sperm infection and its correlation with sperm parameters in a cohort of young adult males.",
"Cross-sectional clinical study.",
"Andrology and Microbiology sections at a university hospital.",
"A cohort of 200 young adult male ... | This is the first report estimating the percentage of HPV-positive sperm in infected subjects and the association between HPV infection and sperm motility. | yes |
19,086,022 | Is aggression related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects? | {
"contexts": [
"Various studies indicate that serotonin regulates impulsivity and the inhibitory control of aggression. Aggression is also known to be modified by sex hormones, which exert influence on serotonergic neurotransmission. The present study aimed to elucidate potential interactions between human aggre... | The present study provides first-time evidence for a specific interrelation between the 5-HT(1A) receptor distribution, sex hormones, and aggression in humans. Our findings point to a reduced down-stream control due to higher amounts or activities of frontal 5-HT(1A) receptors in more aggressive subjects, which is pres... | yes |
19,110,944 | Is [ Acute scrotum a condition requiring surgical intervention ]? | {
"contexts": [
"Acute scrotum (AS) is a clinical syndrome, in which authors indicate a surgical exploration of the scrotum. We retrospectively analyzed the group of 354 patients in 10 years (1997-2006) to compare the preoperative findings with the diagnosis of surgical exploration. The aim was to actualize diagn... | Testicular torsion and tumor are the units in which the surgical exploration is performed without discussion. Beside that, torsion of the testicular or epididymic appendix is the most frequent occurring diagnosis. There is a group of surgeons, who performed in this unit conservative management. | yes |
19,085,896 | Does successful AV fistula creation lead to higher catheter use : the experience by the Northwest Renal Network 16 Vascular Access Quality Improvement Program . Four years follow-up? | {
"contexts": [
"In 2002, the Center for Medicare and Medicaid Services (CMS) required all 18 Renal Networks to participate in a Vascular Access Quality Improvement Program (QIP). The Northwest Renal Network (NWRN 16) chose to increase arteriovenous fistula (AVF) use. NWRN 16 hypothesized that strategies which ta... | The success of Network 16's AVF interventions demonstrates the effectiveness of Network education promoting multidisciplinary teamwork, and innovative strategies to increase dramatically AVF use without substantial increase in catheter use. | no |
19,095,662 | Do phenotypes of the ovarian follicular basal lamina predict developmental competence of oocytes? | {
"contexts": [
"The ovarian follicular basal lamina underlies the epithelial membrana granulosa and maintains the avascular intra-follicular compartment. Additional layers of basal lamina occur in a number of pathologies, including pili annulati and diabetes. We previously found additional layers of follicular b... | These findings provide direct evidence that the phenotype of the follicular basal lamina is related to oocyte competence. | yes |
19,095,664 | Is endometrial fluid a specific and non-invasive biological sample for protein biomarker identification in endometriosis? | {
"contexts": [
"The development of non-invasive diagnostic methods for endometriosis requires sensitive and disease specific biomarkers. Here, we describe the use of aspirated endometrial fluid from women with and without endometriosis as a novel biological sample for biomarker discovery.",
"Differential pro... | Endometrial fluid represents a novel sample for proteomic analysis offering reliable, disease specific information on protein expression, facilitating the discovery of biomarkers for endometriosis. The results described here complement previous proteomic studies, providing new endometriosis-related proteins to be valid... | yes |
19,107,835 | Does rate of inpatient weight restoration predict outcome in anorexia nervosa? | {
"contexts": [
"To examine weight restoration parameters during inpatient treatment as predictors of outcome in anorexia nervosa (AN).",
"Adolescent and adult females admitted for inpatient eating disorder treatment were recruited for an ongoing longitudinal study. This analysis examined several weight resto... | Weight gain rate during inpatient treatment for AN was a significant predictor of short-term clinical outcome after discharge. It is unclear whether weight gain rate exerts a causal effect or is rather a marker for readiness to tolerate weight restoration and engage in the recovery process. | yes |
19,088,475 | Is wound healing impaired in rats undergoing perioperative treatment with the antineoplastic agent taurolidine? | {
"contexts": [
"The aim of this study was to determine whether an intravenous or an intraperitoneal application of the antineoplastic agent taurolidine (TRD) impairs wound healing in the absence of tumor load in rats.",
"Eighty rats were randomized into eight groups (n = 10). Median laparotomy was performed ... | Our results suggest that wound healing does not seem to be impaired by TRD in rats. | no |
19,106,274 | Is the Finnish Diabetes Risk Score associated with insulin resistance and progression towards type 2 diabetes? | {
"contexts": [
"The Finnish Diabetes Risk Score (FINDRISC) questionnaire is a practical screening tool to estimate the diabetes risk and the probability of asymptomatic type 2 diabetes. In this study we evaluated the usefulness of the FINDRISC to predict insulin resistance in a population at increased diabetes r... | The results indicate that the FINDRISC can be applied to detect insulin resistance in a population at high risk for type 2 diabetes and predict future impairment of glucose tolerance. | yes |
19,085,966 | Does hepatocyte-specific deletion of Cdc42 result in delayed liver regeneration after partial hepatectomy in mice? | {
"contexts": [
"Cdc42, a member of the Rho guanosine triphosphatase (GTPase) family, plays important roles in the regulation of the cytoskeleton, cell proliferation, cell polarity, and cellular transport, but little is known about its specific function in mammalian liver. We investigated the function of Cdc42 in... | Our results revealed important roles of Cdc42 in the regulation of proliferative signaling during liver regeneration. | yes |
19,116,473 | Does the economics of new faculty hire in basic science? | {
"contexts": [
"To compare the streams of expenses and revenues associated with investment in a cohort of basic science investigators at the University of Rochester School of Medicine & Dentistry for seven years.",
"The authors evaluated a medical school's financial investment in 25 basic science faculty who... | Investments in basic science research, even when successful, may require significant financial subsidies from academic health centers. | yes |
19,104,407 | Does islet transplantation with alemtuzumab induction and calcineurin-free maintenance immunosuppression result in improved short- and long-term outcomes? | {
"contexts": [
"Only a minority of islet transplant recipients maintain insulin independence at 5 years under the Edmonton protocol of immunosuppression. New immunosuppressive strategies are required to improve long-term outcomes.",
"Three subjects with unstable type 1 diabetes mellitus underwent islet trans... | Islet transplantation with alemtuzumab induction was well tolerated and resulted in improved short- and long-term outcomes. Further investigation is underway for validation. | yes |
19,104,174 | Does glucose infusion suppress surgery-induced muscle protein breakdown by inhibiting ubiquitin-proteasome pathway in rats? | {
"contexts": [
"It appears to have been well established that after surgery, protein catabolism is accelerated and glucose infusion suppresses the catabolic reactions. However, in the early postoperative period, the effects of surgical stress and glucose infusion on muscle protein catabolism and the related mech... | The present study indicates that glucose infusion, even at a relatively low rate, suppresses muscle protein breakdown in the early postoperative period. The mechanism of this effect is related to the suppression of the ubiquitin-proteasome pathway, accompanied by activation of insulin signaling. | yes |
19,104,172 | Is preoperative use of statins associated with reduced early delirium rates after cardiac surgery? | {
"contexts": [
"Delirium is an acute deterioration of brain function characterized by fluctuating consciousness and an inability to maintain attention. Use of statins has been shown to decrease morbidity and mortality after major surgical procedures. The objective of this study was to determine an association be... | Preoperative administration of statins is associated with the reduced risk of postoperative delirium after cardiac surgery with cardiopulmonary bypass. | yes |
19,088,481 | Is positive adnexal or uterine serosal involvement in stage IIIC endometrial cancer an adverse factor for recurrence? | {
"contexts": [
"Clinical and pathological significance of stage IIIC endometrial cancer is unclear. Our study was designed to determine the risk of recurrence among patients with stage IIIC endometrial cancer according to different pathological findings.",
"We retrospectively reviewed all patients with FIGO ... | Patients with stage IIIC endometrial cancer and metastasis to adnexae and/or serosa have a higher risk of recurrence than those with node metastasis alone. Optimal adjuvant therapy for these groups remains unclear. | yes |
19,106,308 | Does perinatal alcohol exposure in rat induce long-term depression of respiration after episodic hypoxia? | {
"contexts": [
"Little is known about the effects of alcohol exposure during pregnancy, which is responsible for fetal alcohol syndrome and the respiratory network functions, especially respiratory network plasticity (e.g., long-term facilitation) elicited after repeated short-lasting hypoxic episodes. The mecha... | Respiratory facilitation after repeated hypoxia was converted to long-term depression in rats treated with alcohol in utero. Alcohol exposure during pregnancy may therefore induce long-term maladaptive behavior of the respiratory system in neonates. | yes |
19,091,714 | Does mobility and fall in people with Huntington 's disease? | {
"contexts": [
"The aim of this study was to estimate the frequency of falls in people with Huntington's disease (HD) and make a preliminary assessment of tools appropriate for assessing the risk of falling.",
"Observational study.",
"Hospital clinic.",
"24 people with HD.",
"Balance was assessed... | A high proportion of HD patients have recurrent falls, and the BBS and TUG appear to be useful in falls risk assessment. | yes |
19,107,340 | Does microvessel density correlate with lymph node metastases and prognosis in hilar cholangiocarcinoma? | {
"contexts": [
"Neovascularization was shown to be critically involved in the progression of multiple cancers, and treatment approaches targeting tumor-associated neovascularization provide convincing results in recent years in some tumor entities. However, little is known about the tumor-associated neovasculari... | Neovascularization is associated with nodal spread as well as local recurrence and serves as an independent prognostic factor for survival after curative resection of hilar cholangiocarcinoma. Therefore, tumor-associated neovascularization seems to be critically involved in the progression of this tumor entity. In addi... | yes |
19,095,296 | Do sFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway? | {
"contexts": [
"Aberrant activation of the Wnt/beta-catenin signaling pathway is common in human cancers, including cervical cancer. The secreted frizzled-related proteins (SFRPs) function as Wnt antagonists and play important implications in carcinogenesis. Recently, we have shown that SFRP1 and SFRP2 are frequ... | Taken together, these data strongly suggest that epigenetic silencing of SFRP genes leads to oncogenic activation of the Wnt pathway and contributes to cervical cancer progression through the EMT program. | yes |
19,089,762 | Do computer-based simulation of the Bielschowsky head-tilt test using the SEE++ software system? | {
"contexts": [
"Latest measurements of the vestibulo-ocular reflex (VOR) allowed the integration of the simulation of the Bielschowsky head-tilt test (BHTT) into the SEE++ software system. SEE++ realizes a biomechanical model of the human eye in order to simulate eye motility disorders and strabismus surgeries. ... | Comparisons of simulation results with patient-measured data showed a good correlation between the simulated and the measured data. Further comparisons with patient data are planned. | yes |
19,087,606 | Does [ Prophylactic administration of Yunnan Baiyao capsule reduce intra-operative blood loss in orthognathic surgery ]? | {
"contexts": [
"To evaluate the haemostatic efficacy and safety of prophylactic oral administration of Yunan Baiyao capsules on reduction of blood loss in bimaxillary orthognathic surgery.",
"Eighty-seven patients scheduled for Le Fort I osteotomy and bilateral sagittal split ramus osteotomy (BSSRO) were enr... | Prophylactic oral administration of Yunnan Baiyao capsules can effectively reduce the intra-operative blood loss in bimaxillary orthognathic surgery. Yunnan Baiyao capsule are an effective and safe haemostatic traditional Chinese medicine. | yes |
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