pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
19,101,059 | Does a regional system of stroke care provide thrombolytic outcomes comparable with the NINDS stroke trial? | {
"contexts": [
"Administration of tissue plasminogen activator (tPA) for acute ischemic stroke remains controversial in community practice. Well-organized hierarchic systems of acute stroke care have been proposed to link community hospitals to comprehensive stroke centers. We report safety and functional outcom... | During a 9-year period, an emergency medicine network with stroke consultants achieved patient outcomes comparable to those reported from the NINDS trial. These results indicate that the NINDS tPA protocol is applicable to community practice, with the support of a university-based brain attack center. | yes |
19,087,307 | Are the FUSE binding proteins FBP1 and FBP3 potential c-myc regulators in renal , but not in prostate and bladder cancer? | {
"contexts": [
"The three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncogene. Whereas it is known that c-myc alterations play a completely different role in va... | The correlation between FBP1/FBP3, c-myc and high proliferation rate in renal cell carcinoma provides strong in vivo support for the suggested role of FBP1 and FBP3 as activators of c-myc. The frequent up-regulation of FBP1 and FBP3 in urothelial and prostate carcinoma suggests that FBPs also have an important function... | yes |
19,116,439 | Do acute explosive-force movements enhance bench-press performance in athletic men? | {
"contexts": [
"The purpose of this investigation was to determine whether the performance of explosive-force movements before bench-press exercise would improve 1-repetition-maximum (1RM) strength.",
"Twelve male college athletes participated in 3 testing sessions separated by at least 5 days of rest. Durin... | These data suggest that an acute bout of low-volume, explosive-force upper body movements performed 30 seconds before a 1RM attempt might enhance bench-press performance in athletic men. | yes |
19,097,856 | Is plum juice , but not dried plum powder , effective in mitigating cognitive deficits in aged rats? | {
"contexts": [
"Normal aging in animals and humans is accompanied by a decline in cognitive performance that is thought to be due to the long-term effects of oxidative stress and inflammation on neurologic processes. Previous findings have suggested that protection against age-related cognitive declines may be a... | These results are discussed in relation to the amount and type of phenolics present in the plum products and in relation to other dietary intervention studies in which cognitive benefits have been reported. | yes |
19,109,805 | Are concomitant injuries an important determinant of outcome of high-grade blunt hepatic trauma? | {
"contexts": [
"Little is known about the clinical importance of concomitant injuries in polytraumatized patients with high-grade blunt liver injury. A retrospective single-centre study was performed to investigate the safety of non-operative management of liver injury and the impact of concomitant intra- and ex... | Concomitant injuries are a major determinant of outcome in patients with blunt hepatic injury and should be given high priority by trauma surgeons. An algorithm for the management of blunt liver injury is proposed. | yes |
19,105,694 | Does gender risk of nonfatal stroke in type 2 diabetic patients differ depending on the type of treatment? | {
"contexts": [
"The gender differences in stroke risk among diabetic patients with different treatments have not been studied previously. We aim to determine if there is a gender difference in nonfatal stroke risk in diabetic patients receiving different types of glucose-lowering treatments.",
"In December 2... | The gender risks of nonfatal stroke in patients with type 2 diabetes appear to differ considerably depending on treatment types. | yes |
19,106,343 | Does development of computerized alert with management strategies for 25 serious drug-drug interactions? | {
"contexts": [
"The development of computerized alerts with management strategies for 25 drug-drug interactions (DDIs) is described."
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Ambulatory Care",
"Drug Information Services",
"Drug Interactions",
"Drug Therapy, Computer-Assisted",
"... | To ensure that clinicians, when confronted with any of 25 serious DDIs in the ambulatory care setting, can avoid these DDIs while treating patients with appropriate medications, management strategies were developed using a consensus approach. Several methods were used to ensure that the recommended alternatives were tr... | yes |
19,086,962 | Is the presence of small intestinal intraepithelial gamma/delta T-lymphocytes inversely correlated with lymphoma development in refractory celiac disease? | {
"contexts": [
"In refractory celiac disease (RCD) type II, a phenotypically aberrant (CD7+ CD3- CD4/8-cytoplasmicCD3+) intraepithelial lymphocyte (IEL) population is present, and 50-60% of these patients develop enteropathy-associated T-cell lymphoma (EATL). TCRgammadelta+ IELs play an important role in mucosal... | The observed negative relation between TCRgammadelta+ and aberrant IELs, along with their known regulatory capacity in uncomplicated CD, implies that TCRgammadelta+ IELs may play a crucial role in mucosal repair, regaining homeostasis and possibly even tumor surveillance. These cells may be important markers, in additi... | yes |
19,095,841 | Do nicotinic receptors partly mediate brainstem autonomic dysfunction evoked by the inhaled anesthetic isoflurane? | {
"contexts": [
"Isoflurane is one of the most commonly used volatile anesthetics, yet the cardiorespiratory depression that occurs with its use remains poorly understood. In this study, the author examined isoflurane modulation of postsynaptic gamma-aminobutyric acid (GABA) receptors in parasympathetic cardiac v... | These results suggest clinically relevant concentrations of isoflurane inhibit brainstem respiratory rhythmogenesis, prolong inhibitory GABAergic postsynaptic currents and reduce GABA activity in CVNs. The decrease of GABAergic IPSCs frequency is dependent upon inhibition of presynaptic alpha(4)beta(2) nicotinic recept... | yes |
19,095,846 | Does tolerance to isoflurane occur in developing Xenopus laevis tadpoles? | {
"contexts": [
"Tolerance is observed for a variety of central nervous system depressants including ethanol, which is an anesthetic, but has not been convincingly demonstrated for a potent halogenated volatile anesthetic. Failure to demonstrate tolerance to these agents may be the result of inadequate exposure t... | We provide the first description of week-long exposures of vertebrates to surgical anesthetic concentrations of isoflurane, and the first report of such exposures in developing vertebrates. Tolerance to isoflurane does not occur in developing Xenopus laevis tadpoles. Taken together with studies in other organisms, the ... | no |
19,090,318 | Does morphine increase acetylcholine release in the trigeminal nuclear complex? | {
"contexts": [
"The trigeminal nuclear complex (V) contains cholinergic neurons and includes the principal sensory trigeminal nucleus (PSTN) which receives sensory input from the face and jaw, and the trigeminal motor nucleus (MoV) which innervates the muscles of mastication. Pain associated with pathologies of ... | These data comprise the first direct measures of ACh release in PSTN and MoV and suggest synaptic disinhibition as one possible mechanism by which morphine increases ACh release in the trigeminal nuclei. | yes |
19,101,266 | Is myocardial revascularization by left ventricular assisted beating heart associated with reduced systemic inflammatory response? | {
"contexts": [
"The present study was designed to investigate whether use of left ventricular assisted technique (LVA) in beating-heart myocardial revascularization would exert less impact on patients' inflammatory response, as compared with minimal extracorporeal circulation (MECC).",
"Seventy-three consecu... | High-risk patients undergoing beating-heart myocardial revascularization with LVA show reduced inflammatory response compared with patients treated with the MECC. | yes |
19,101,265 | Does cerebral oxygen desaturation predict cognitive decline and longer hospital stay after cardiac surgery? | {
"contexts": [
"Previous studies have reported an 11% to 75% incidence of postoperative cognitive decline among cardiac surgery patients. The INVOS Cerebral Oximeter (Somanetics Corp, Troy, MI) is a Food and Drug Administration approved device that measures regional cerebral oxygen (rSo(2)) saturation. The purpo... | Intraoperative cerebral oxygen desaturation is significantly associated with an increased risk of cognitive decline and prolonged hospital stay after CABG. | yes |
19,110,222 | Is hyperhomocysteinemia sufficient to cause preeclampsia in an animal model : the importance of folate intake? | {
"contexts": [
"The objective of our study was to determine whether methylenetetrahydrofolate reductase (Mthfr)-deficient mice develop preeclampsia (PE).",
"Mice were placed on a normal or low-folate/high-methionine (LF/HM) diet to assess the impact of mild and severe homocysteinemia. Blood pressure and prot... | Our study clearly demonstrates that hyperhomocysteinemia is not sufficient to cause PE in this animal model. Furthermore, it confirms the importance of folate intake on pregnancy outcomes. | no |
19,106,740 | Does comparison of two VA laboratory data repositories indicate that missing data vary despite originating from the same source? | {
"contexts": [
"Assessing accuracy and completeness of data is an important component of conducting research. VA Healthcare System benefits from a highly developed electronic medical information system. The Immunology Case Registry was designed to monitor costs and quality of HIV care. The Decision Support Syste... | Six of the laboratory tests demonstrated remarkably similar amounts of overlap, though Immunology Case Registry and Decision Support System both have missing data. Findings indicate that validation of laboratory data should be conducted before its use in quality and efficiency projects. When 2 databases are not availab... | yes |
19,099,987 | Does [ Recombinant human growth hormone promote in vitro mesenchymal stem cell growth ]? | {
"contexts": [
"To detect the effect of recombinant human growth hormone (rhGH) to mesenchymal stem cells (MSCs) in vitro.",
"Various concentrations of rhGH (terminal concentrations 1, 10, 50, 100, 200 and 500 microg/L) were added to medium containing the second generation of MSCs, A value was measured by MT... | rhGH could promote the growth of MSCs in vitro. | yes |
19,088,021 | Do dNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers? | {
"contexts": [
"About 15% of colorectal cancers harbor microsatellite instability (MSI). MSI-associated gene expression changes have been identified in colorectal cancers, but little overlap exists between signatures hindering an assessment of overall consistency. Little is known about the causes and downstream ... | Our results show cross-study consistency of MSI-associated gene expression changes in colorectal cancers. DNA copy-number alterations partly cause the differences in gene expression between MSI and MSS cancers. | yes |
19,117,522 | Does human prostate support more efficient replication of HIV-1 R5 than X4 strains ex vivo? | {
"contexts": [
"In order to determine whether human prostate can be productively infected by HIV-1 strains with different tropism, and thus represent a potential source of HIV in semen, an organotypic culture of prostate from men undergoing prostatic adenomectomy for benign prostate hypertrophy (BPH) was develop... | The BPH prostate is a site of HIV-1 R5 replication that could contribute virus to semen. A limited spreading of HIV-1 X4 and R5X4 in this organ could participate to the preferential sexual transmission of HIV-1 R5 strains. | yes |
19,117,526 | Does inhibition of HMG CoA reductase reveal an unexpected role for cholesterol during PGC migration in the mouse? | {
"contexts": [
"Primordial germ cells (PGCs) are the embryonic precursors of the sperm and eggs. Environmental or genetic defects that alter PGC development can impair fertility or cause formation of germ cell tumors.",
"We demonstrate a novel role for cholesterol during germ cell migration in mice. Choleste... | In the mouse, cholesterol is required for PGC survival and motility. It may act cell-autonomously by regulating clustering of growth factor receptors within PGCs or non cell-autonomously by controlling release of growth factors required for PGC guidance and survival. | yes |
19,100,997 | Does gray matter atrophy correlate with MS disability progression measured with MSFC but not EDSS? | {
"contexts": [
"Gray matter (GM) pathology is an important component of the multiple sclerosis (MS) disease process. Accelerated gray matter atrophy has been observed in MS patients, but its relationship to neurological disability is not defined. This study was done to determine the relationship between whole br... | Whole brain, GM, and WM atrophy predicted MS disability progression observed over the next 6.6 years. Gray matter atrophy rates over 4 years correlated with disability progression measured with the MSFC, but not EDSS. This indicates that MSFC defined disability progression is more closely linked to brain atrophy than E... | yes |
19,095,266 | Does obesity decrease the accuracy of testicular examination in anesthetized boys with cryptorchidism? | {
"contexts": [
"Given that the prevalence of childhood obesity is increasing in the United States, we tested the timely hypothesis that obesity hinders physical examination based localization of the cryptorchid testis.",
"Body mass index and percentiles of weight for height and body mass index for age were c... | In our series childhood obesity did not make preoperative testicular examinations under anesthesia less accurate. However, office examinations may be more accurate in nonobese boys. | no |
19,095,263 | Does cXCR3-B expression correlate with tumor necrosis extension in renal cell carcinoma? | {
"contexts": [
"We investigated the expression of the 2 spliced variants of the CXCR3 receptor (CXCR3-A and CXCR3-B) and their ligands (MIG, IP-10 and I-TAC) in patients with renal cell carcinoma according to conventional prognostic factors and the necrosis pattern.",
"A total of 59 patients with renal cell ... | Results demonstrate that CXCR3-B is an independent determinant factor for the extensive tumor necrosis pattern. These data emphasize the immunoangiostatic activity of the CXCR3/CXCR3 ligand biological axis for nonmetastatic human renal cell carcinoma. | yes |
19,086,996 | Does cellular interaction regulate interleukin-8 secretion by granulosa-lutein cells and monocytes/macrophages? | {
"contexts": [
"Peri-ovulatory migration of leukocytes towards the follicle plays an important role during corpus luteum formation. In this study, we examined the secretion of the neutrophil chemoattractant interleukin (IL)-8 by ovarian GL cells and the role of monocytes in IL-8 secretion.",
"Granulosa-lutei... | Human GL cells constitutively synthesize IL-8. An increased IL-8 secretion by co-cultured GL cells and THP-1 cells suggest that GL cells and monocytes mutually induce chemokine secretion. An initial interaction between GL cells and ovarian leukocytes may therefore contribute to an increased chemokine release and leukoc... | yes |
19,086,992 | Do human uterine NK cells interact with uterine macrophages via NKG2D upon stimulation with PAMPs? | {
"contexts": [
"The initiation of an immune response often involves the cooperation of various innate immune cells. In the human endometrium, uterine natural killer (uNK) cells and uterine macrophages are present in significant numbers and in close proximity, yet how they cooperatively respond to infectious chal... | This study demonstrates that the NKG2D-MICA interaction is an important molecular mechanism that is involved in the innate immune response to microbial signals in the human uterine endometrium. | yes |
19,086,993 | Does the polycystic ovary syndrome predict further miscarriage in Japanese couples experiencing recurrent miscarriages? | {
"contexts": [
"It has been a matter of controversy whether the polycystic ovary syndrome (PCOS) is actually a causal factor of miscarriages because of the absence of internationally established criteria. We, therefore, in this study investigated whether PCOS and a polycystic ovary (PCO) morphology have predicti... | A routine test for diagnosis of PCOS is not necessary in patients experiencing recurrent miscarriages because none of the related parameters examined in this study predicted subsequent miscarriage. | no |
19,095,108 | Does preoperative performance status predict outcome following heated intraperitoneal chemotherapy? | {
"contexts": [
"Peritoneal carcinomatosis has a typical natural history of bowel obstruction and death. Significant evidence suggests that cytoreduction with heated intraperitoneal chemotherapy (HIPEC) improves long-term survival for these tumors.",
"A retrospective case series of patients who underwent init... | Cytoreduction and HIPEC can be done at moderate-volume centers with morbidity and mortality rates comparable with published results from large-volume centers. Preoperative performance status and the extent of disease predict postoperative complications. | yes |
19,094,076 | Is predisposition to vitamin D deficiency osteomalacia and rickets in females linked to their 25 ( OH ) D and calcium intake rather than vitamin D receptor gene polymorphism? | {
"contexts": [
"Osteomalacia (OSM) and rickets are widely prevalent in developing countries especially in females. The factors associated with such predisposition are not known.",
"To identify nutritional, endocrine and genetic factors related to calcium and vitamin D metabolism that are associated with OSM/... | Among the immediate family members of patients with OSM/rickets, female sibs have features of biochemical OSM in up to 24.4%. Female sibs, unlike male sibs, share with patients features of markedly low serum 25(OH)D levels, poor dietary calcium intake and poor exposure to sunshine. Genetic factors such as VDR and PTH g... | yes |
19,110,304 | Is vitamin A metabolism impaired in human ovarian cancer? | {
"contexts": [
"We have previously reported that loss in expression of a protein considered critical for vitamin A homeostasis, cellular retinol-binding protein 1 (CRBP1), is an early event in ovarian carcinogenesis. The aim of the present study was to determine if loss of vitamin A metabolism also occurs early ... | The impaired conversion of retinol to RA in ovarian cancer cells and decreased CRBP1 protein expression in prophylactic oophorectomies support our hypothesis that concomitant losses of vitamin A metabolism and CRBP1 expression contribute to ovarian oncogenesis. | yes |
19,087,881 | Does acetyl-Ile-Gly-Leu protect neurons from Abeta ( 1-42 ) induced toxicity in vitro and in V337M human tau-expressing mice? | {
"contexts": [
"We previously reported that the neurotoxicity of amyloid beta protein (Abeta(1-42), 10 nM) was blocked by an Abeta-derived tripeptide, Abeta(32-34) (Ile-Gly-Leu, IGL), suggesting that IGL may be a lead compound in the design of Abeta antagonists. In the present study, three stable forms of IGL pe... | These results suggest that a modified tripeptide, acetyl-IGL, may be effective in the treatment of Alzheimer's disease. | yes |
19,109,740 | Do tubular epithelial cells have the capacity to transdifferentiate into CD68-positive macrophage-like cells by oxidative stress? | {
"contexts": [
"The present study was intended to assess transdifferentiation from tubular epithelial cells to macrophage- like cells.",
"Puromycin aminonucleoside nephrotic rats were sacrificed at days 4, 8, 24 and 112. We immunohistochemically evaluated CD68, CD163, and cytokeratin AE1/AE3, known as marker... | We confirmed that tubular epithelial cells have the capacity to transdifferentiate to CD68-positive macrophage-like cells, which may be linked to oxidative stress. | yes |
19,108,709 | Do eptifibatide and abciximab inhibit insulin-induced focal adhesion formation and proliferative responses in human aortic smooth muscle cells? | {
"contexts": [
"The use of abciximab (c7E3 Fab) or eptifibatide improves clinical outcomes in diabetics undergoing percutaneous coronary intervention. These beta3 integrin inhibitors antagonize fibrinogen binding to alphaIIbbeta3 integrins on platelets and ligand binding to alphavbeta3 integrins on vascular cell... | Insulin elicited a dose-dependent proliferative response in HASMC. Pretreatment with m7E3 (an anti-beta3 integrin monoclonal antibody from which abciximab is derived), c7E3 or LM609 inhibited proliferative responses to insulin by 81%, 59% and 28%, respectively. Eptifibatide or cyclic RGD peptides completely abolished i... | yes |
19,099,607 | Is lIM only 4 overexpressed in late stage pancreas cancer? | {
"contexts": [
"LIM-only 4 (LMO4), a member of the LIM-only (LMO) subfamily of LIM domain-containing transcription factors, was initially reported to have an oncogenic role in breast cancer. We hypothesized that LMO4 may be related to pancreatic carcinogenesis as it is in breast carcinogenesis. If so, this could... | Pancreatic carcinomas (both IDC and IPMC) expressed significantly higher levels of LMO4 mRNA than did normal ductal epithelia, PanIN-1B, PanIN-2, IPMA and IPMB. These results suggested that LMO4 is overexpressed at late stages in carcinogenesis of pancreatic cancer. | yes |
19,108,755 | Does herb-partition moxibustion relieve chronic visceral hyperalgesia and 5-HT concentration in colon mucosa of rats? | {
"contexts": [
"The aim of this study was to evaluate the effect of herb-partition moxibustion on rectal sensory thresholds and to analyse possible mechanism of herb-partition moxibustion in treating chronic visceral hypersensitivity rats.",
"Herb-partition moxibustion was administered to chronic visceral hy... | Herb-partition moxibustion enhances the pain threshold of chronic visceral hypersensitivity rats and restores normal sensitivity by 5-hydroxytryptamine concentration decreased in the colon tissue. However, whether herb-partition moxibustion could enhance the pain threshold of IBS patients or not is not concluded in thi... | yes |
19,107,339 | Is precise histological evaluation of liver biopsy specimen indispensable for diagnosis and treatment of acute-onset autoimmune hepatitis? | {
"contexts": [
"The diagnosis of acute-onset autoimmune hepatitis (AIH) has been difficult because patients do not always show clinicopathological features typical of AIH. We examined the important requirements for a definitive diagnosis of acute-onset AIH.",
"Clinical, biochemical, and pathological features... | Histological examination of the liver is necessary for early diagnosis of acute-onset AIH. Moreover, we should evaluate liver biopsy specimens precisely and should be ready for a timely initiation of corticosteroid therapy to improve the prognosis. | yes |
19,102,988 | Do [ Treatment of burn cicatricial foot drop with Ilizarov fixator ]? | {
"contexts": [
"To investigate the efficacy of Ilizarov fixator on cicatricial foot drop after burn.",
"Six patients with cicatricial foot drop after burn were treated with Ilizarov fixator during June 2004 approximately October 2007, the fixator was set on the leg and foot by fixed bone needles. Nuts on the... | Ilizarov fixator is safe and mini-injury, which is an effective method for treatment of cicatricial foot drop. | yes |
19,116,934 | Is the chromosome 7q region association with rheumatoid arthritis in females in a British population replicated in a North American case-control series? | {
"contexts": [
"The single-nucleotide polymorphism (SNP) rs11761231 on chromosome 7q has been reported to be sexually dimorphic marker for rheumatoid arthritis (RA) susceptibility in a British population. We sought to replicate this finding and to better characterize susceptibility alleles in the region in a Nor... | While 2 SNPs on chromosome 7q appeared to be associated with RA in a North American cohort, the significance of this finding did not withstand correction for population substructure. Our results emphasize the need to carefully account for population structure to avoid false-positive disease associations. | no |
19,100,072 | Does [ Endothelin-1 overexpression inhibit rat pulmonary arterial microvascular smooth muscle cell apoptosis via Akt/PKB pathway ]? | {
"contexts": [
"To investigate the effects of endothelin-1 (ET-1) overexpression on apoptosis of the rat pulmonary arterial microvascular smooth muscle cells (RPMC) in vitro.",
"Primary RPMC obtained from the pulmonary artery and lung microvasculature were identified by immunofluorescence staining and electr... | Overexpression of the ET-1 inhibited RPMC apoptosis and activated Akt/PKB-Caspase-3 signaling pathway, which might be responsible for ET-1 induced the pulmonary microvascular arteries remodeling. | yes |
19,105,906 | Does economic influence on GPs ' decisions to provide out-of-hours care? | {
"contexts": [
"Introduction of the new general medical services contract offered UK general practices the option to discontinue providing out-of-hours (OOH) care. This aimed to improve GP recruitment and retention by offering a better work-life balance, but put primary care organisations under pressure to ensur... | The opportunity to opt out of OOH care has provided flexibility for GPs to raise additional income, although primary care organisations vary in the extent to which they offer these opportunities. Examining intrinsic motivation is an area for future study. | yes |
19,106,744 | Does homeobox gene CDX2 inhibit human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity? | {
"contexts": [
"Homeobox gene caudal related homeobox gene 2 (CDX2) is an intestine-specific tumor suppressor gene. This study is intended to investigate the effect of CDX2 expression on cell proliferation and cyclin D1 expression in pancreatic cancer cells.",
"Four pancreatic ductal adenocarcinoma cell line... | CDX2 might play a role in inhibiting cell proliferation and repressing cyclin D1 transcriptional activity through the proximal nuclear factor kappaB binding site in pancreatic cancer cells. | yes |
19,110,909 | Do sociodemographic factors predict early discontinuation of HIV non-nucleoside reverse transcriptase inhibitors and protease inhibitors? | {
"contexts": [
"HIV infection has a devastating impact on individual and public health, and affects populations disproportionately. Treatment with antiretroviral therapy (ART) saves lives, but long-term adherence to ART is critical to its success. We performed an observational cohort study to determine the influ... | Our results suggest that sociodemographic factors were associated with early NNRTI and PI discontinuation in this population, and some factors were ART class specific. | yes |
19,100,966 | Does positive allosteric modulation of mGluR5 receptors facilitate extinction of a cocaine contextual memory? | {
"contexts": [
"The perseverance of the motivational salience of drug-associated memories is an obstacle to the successful treatment of drug addiction and is often a causative factor in triggering relapse.",
"This study was intended to determine whether potentiation of type 5 metabotropic glutamate receptors... | Positive allosteric modulation of mGluR5 function facilitates the extinction of a cocaine-associated contextual memory, which may represent a novel approach toward enhancing extinction learning in the context of drug addiction. | yes |
19,095,996 | Is leukocyte cathepsin S a potent regulator of both cell and matrix turnover in advanced atherosclerosis? | {
"contexts": [
"A dysbalance of proteases and their inhibitors is instrumental in remodeling of atherosclerotic plaques. One of the proteases implicated in matrix degradation is cathepsin-S (CatS). To address its role in advanced lesion composition, we generated chimeric LDLr(-/-) mice deficient in leukocyte Cat... | Leukocyte CatS deficiency results in considerably altered plaque morphology, with smaller necrotic cores, reduced apoptosis, and decreased SMC content and collagen deposition and may thus be critical in plaque stability. | yes |
19,091,317 | Is 25-Hydroxyvitamin D deficiency independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey? | {
"contexts": [
"Serum 25-hydroxyvitamin D [25(OH)D] levels are inversely associated with important cardiovascular disease (CVD) risk factors. However, the association between 25(OH)D levels and prevalent CVD has not been extensively examined in the general population.",
"We performed a cross-sectional analys... | These results indicate a strong and independent relationship of 25(OH)D deficiency with prevalent CVD in a large sample representative of the US adult population. | yes |
19,111,727 | Does endothelial caveolin-1 regulate pathologic angiogenesis in a mouse model of colitis? | {
"contexts": [
"Increased vascular density has been associated with progression of human inflammatory bowel diseases (IBDs) and animal models of colitis. Pathologic angiogenesis in chronically inflamed tissues is mediated by several factors that are regulated at specialized lipid rafts known as caveolae. Caveoli... | Endothelial Cav-1 mediates angiogenesis in experimental colitis. Modulation of Cav-1 could provide a novel therapeutic target for IBD. | yes |
19,087,546 | Do [ Proteasome inhibitors sensitize ovarian cancer cells to paclitaxel induced apoptosis ]? | {
"contexts": [
"To explore the sensitivity of ovarian cancer cell line SKOV3 to paclitaxel, proteasome inhibitors, bortezomib, and their combination.",
"The methyl thiazolyl tetrazolium (MTT) assay was applied to examine the cell viability after treatment. The annexin V-propidium iodide apoptosis detection k... | The lethal effect of paclitaxel on tumor cells could be increased significantly by its combination with proteasome inhibitors, bortezomib. The AKT/GSK-3beta signaling pathway plays an important role in the molecular mechanism of the combination treatment. | yes |
19,102,897 | Is [ Serum triglyceride an independent risk factor for acute coronary heart disease events in 35 - 64 years old Chinese-Chinese Multi-provincial Cohort Study . ]? | {
"contexts": [
"To evaluate the association between serum triglyceride (TG) and the cardiovascular diseases (CVD) risk in Chinese population.",
"A total of 30, 378 men and women aged 35 - 64 years old were recruited in the Chinese-Chinese Multi-provincial Cohort Study (CMCS). The serum TG and other CVD risk ... | Serum TG is an independent risk factor for acute CHD events in Chinese population aged 35 - 64. | yes |
19,106,245 | Is visceral fat mass a strong predictor of circulating ghrelin levels in premenopausal women? | {
"contexts": [
"A well known inverse relationship exists between obesity and circulating ghrelin concentrations. However, obesity is a heterogeneous disease entity and upper-body obesity (UBO) is associated with more profound metabolic disturbances than lower-body obesity (LBO). We therefore aimed to investigate... | Visceral fat mass is a strong predictor of basal ghrelin concentrations and also attenuates the suppressive effect of insulin on ghrelin concentrations. These data provide further evidence that the UBO phenotype is associated with more profound metabolic abnormalities than obesity per se. | yes |
19,106,243 | Does protein supplementation before and after exercise further augment skeletal muscle hypertrophy after resistance training in elderly men? | {
"contexts": [
"Considerable discrepancy exists in the literature on the proposed benefits of protein supplementation on the adaptive response of skeletal muscle to resistance-type exercise training in the elderly.",
"The objective was to assess the benefits of timed protein supplementation on the increase i... | Timed protein supplementation immediately before and after exercise does not further augment the increase in skeletal muscle mass and strength after prolonged resistance-type exercise training in healthy elderly men who habitually consume adequate amounts of dietary protein. This trial was registered at clinicaltrials.... | no |
19,091,060 | Does quantitative protein expression profiling reveal extensive post-transcriptional regulation and post-translational modifications in schizont-stage malaria parasites? | {
"contexts": [
"Malaria is a one of the most important infectious diseases and is caused by parasitic protozoa of the genus Plasmodium. Previously, quantitative characterization of the P. falciparum transcriptome demonstrated that the strictly controlled progression of these parasites through their intra-erythro... | Together, our data indicate that both post-transcriptional and post-translational events are widespread and of presumably great biological significance during the intra-erythrocytic development of P. falciparum. | yes |
19,091,068 | Is vitamin C in plasma inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women? | {
"contexts": [
"The prevalence of hypertension and its contribution to cardiovascular disease risk makes it imperative to identify factors that may help prevent this disorder. Extensive biological and biochemical data suggest that plasma ascorbic acid may be such a factor. In this study we examined the associati... | Plasma ascorbic acid was found to be inversely associated with BP and change in BP during the prior year. The findings suggest the possibility that vitamin C may influence BP in healthy young adults. Since lower BP in young adulthood may lead to lower BP and decreased incidence of age-associated vascular events in olde... | yes |
19,101,431 | Do laser flare photometry in the therapeutic management of bacterial chronic pseudophakic endophthalmitis? | {
"contexts": [
"To evaluate laser flare photometry in measuring aqueous humor inflammation in chronic pseudophakic endophthalmitis.",
"Department of Ophthalmology, Pitié Salpétrière Hospital, Paris, France.",
"This retrospective review comprised eyes with chronic pseudophakic endophthalmitis that were ev... | Laser flare photometry, a noninvasive objective tool, was useful in monitoring the evolution of chronic pseudophakic endophthalmitis. Early detection of an increase in flare could lead to a close follow-up. The prompt modification of therapeutic intervention could help preserve a favorable visual outcome. | yes |
19,106,164 | Is dose escalation of infliximab therapy in arthritis patients related to diagnosis and concomitant methotrexate treatment : observational results from the South Swedish Arthritis Treatment Group register? | {
"contexts": [
"To study frequency of dose escalation in infliximab-treated patients and to identify possible predictors thereof.",
"Patients with chronic arthritis initiating their first course of anti-TNF treatment with infliximab at Lund University Hospital were included in a structured clinical follow-up... | Dose escalations were performed in 59% of all infliximab-treated patients during the first 2 yrs of treatment. Our data suggest that PsA patients might require higher dosages than RA and AS patients. | yes |
19,087,269 | Is normal mitochondrial respiratory function essential for spatial remote memory in mice? | {
"contexts": [
"Mitochondrial DNA (mtDNA) with pathogenic mutations has been found in patients with cognitive disorders. However, little is known about whether pathogenic mtDNA mutations and the resultant mitochondrial respiration deficiencies contribute to the expression of cognitive alterations, such as impair... | Our results indicated that normal mitochondrial respiratory function is necessary for retention and consolidation of memory trace; deficiencies in this function due to high loads of pathogenically mutated mtDNA are responsible for the preferential impairment of spatial remote memory. | yes |
19,085,998 | Does socioeconomic deprivation influence the severity of Crohn 's disease : Results of a prospective multicenter study? | {
"contexts": [
"Socioeconomic deprivation is associated with poor health. The aims of this study were to evaluate the influence of deprivation in the characteristics and comparisons of deprived and nondeprived Crohn's disease (CD) patients.",
"CD patients were prospectively recruited from September 2006 to J... | In this study deprivation does not seem to influence the severity of CD. This can be explained by easy access to healthcare in France. | no |
19,103,187 | Does apolipoprotein E4 allele influence the response of plasma triglyceride levels to tamoxifen in breast cancer patients? | {
"contexts": [
"Apolipoprotein E4 (APOE4) allele is an important risk factor for breast cancer and affects clearance of chylomicron remnants. Tamoxifen therapy increases serum triglyceride levels and sometimes inducing severe hypertriglyceridemia in breast cancer patients.",
"Thirty-three women with breast c... | These findings indicate that the effects of tamoxifen on plasma triglyceride levels are modified by APOE polymorphism. Breast cancer patients with APOE4 allele have low plasma triglyceride levels when receiving tamoxifen therapy. Therefore, we suggest that APOE gene polymorphism is a critical validation before tamoxife... | yes |
19,100,012 | Does [ Tongxinluo improve vascular endothelial function in patients with type 2 diabetes ]? | {
"contexts": [
"To investigate the effects of Tongxinluo on vascular endothelial function in patients with type 2 diabetes.",
"A total of 80 patients with type 2 diabetes were recruited and divided into two groups: Tongxinluo therapy group (n = 40) and conventional therapy group (n = 40). Plasma levels of NO... | Tongxinluo improved the vascular endothelial dependent diastolic function in patients with type 2 diabetes by regulating the balance of plasma NO/ET. | yes |
19,100,675 | Does erythropoietin-induced phosphorylation/degradation of BIM contribute to survival of erythroid cells? | {
"contexts": [
"A proapoptotic BH3-only protein BIM (BCL-2 interacting mediator of cell death) can link cytokine receptor signaling with the apoptotic machinery in hematopoietic cells. We investigated here the role of BIM in erythropoietin (EPO)-mediated survival in erythroid cells.",
"We downregulated BIM i... | EPO protects erythroid cells from apoptosis in part through ERK-mediated phosphorylation followed by proteasomal degradation of BIM. | yes |
19,105,810 | Does mycobacterium tuberculosis interactome analysis unravel potential pathways to drug resistance? | {
"contexts": [
"Emergence of drug resistant varieties of tuberculosis is posing a major threat to global tuberculosis eradication programmes. Although several approaches have been explored to counter resistance, there has been limited success due to a lack of understanding of how resistance emerges in bacteria u... | The study leads to the identification of possible pathways for drug resistance, providing novel insights into the problem of resistance. Knowledge of important proteins in such pathways enables identification of appropriate 'co-targets', best examples being RecA, Rv0823c, Rv0892 and DnaE1, for drugs targeting the mycol... | yes |
19,103,674 | Does donor blood glucose 6-phosphate dehydrogenase deficiency reduce the efficacy of exchange transfusion in neonatal hyperbilirubinemia? | {
"contexts": [
"Acute intravascular hemolysis after exchange transfusion with glucose 6-phosphate dehydrogenase-deficient blood has been reported; however, it is not routine to screen donor blood for glucose 6-phosphate dehydrogenase deficiency while performing exchange transfusion. We hypothesized that exchange... | Exchange transfusion with glucose 6-phosphate dehydrogenase-deficient donor blood leads to a lesser drop in postexchange total serum bilirubin. It prolongs the duration of phototherapy and increases the need for repeat exchange transfusions. | yes |
19,088,082 | Is activation of neutral sphingomyelinase involved in acute hypoxic pulmonary vasoconstriction? | {
"contexts": [
"The mechanisms involved in hypoxic pulmonary vasoconstriction (HPV) are not yet fully defined. The aim of the study was to determine the role of protein kinase C zeta (PKCzeta) and neutral sphingomyelinase (nSMase) in HPV.",
"Ceramide content was measured by immunocytochemistry and voltage-ga... | nSMase-derived ceramide production and the activation of PKCzeta are early and necessary events in the signalling cascade of acute HPV. | yes |
19,096,000 | Do certain progestins prevent the enhancing effect of 17beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells? | {
"contexts": [
"Estro-progestin treatments have been associated with an increased risk of thromboembolic events in postmenopausal women. This study examined whether progestins affect the stimulatory effect of estrogens on the endothelial formation of nitric oxide (NO), a potent antithrombotic factor.",
"Expe... | Certain progestins, including MPA, attenuate the 17beta-E-induced NO-mediated inhibition of platelet aggregation by endothelial cells through preventing both eNOS and GTPCH I expression most likely via activation of glucocorticoid receptors. | yes |
19,116,670 | Is calnexin essential for mammalian rod opsin biogenesis? | {
"contexts": [
"Misfolding mutations in rod opsin are a major cause of the inherited blindness retinitis pigmentosa. Therefore, understanding the role of molecular chaperones in facilitating rod opsin biogenesis and the response to mutant rod opsin is important for retinal disease and fundamental retinal cell bi... | Our data show that, unlike Drosophila Rh1, mammalian rod opsin biogenesis does not appear to have an absolute requirement for Cnx. Other chaperones are likely to be more important for mammalian rod opsin biogenesis and quality control. | no |
19,099,565 | Do phylogeography and historical demography of the Lusitanian snail Elona quimperiana reveal survival in unexpected separate glacial refugia? | {
"contexts": [
"Present day distributions of Palearctic taxa in northern latitudes mainly result from populations having survived in local patches during the Late Pleistocene and/or from recolonizing populations from southern temperate refugia. If well-studied Mediterranean and eastern European refugia are widel... | Present results confirm the Iberian origin of the land snail E. quimperiana and strongly support the emerging phylogeographic hypothesis of multiple refugia in Iberia during the last glaciations. The scenario of a spatial expansion of E. quimperiana from an Iberian refuge located in Asturias to northern areas provides ... | yes |
19,114,918 | Does therapeutic hypothermia preserve antioxidant defenses after severe traumatic brain injury in infants and children? | {
"contexts": [
"Oxidative stress contributes to secondary damage after traumatic brain injury (TBI). Hypothermia decreases endogenous antioxidant consumption and lipid peroxidation after experimental cerebral injury. Our objective was to determine the effect of therapeutic hypothermia on oxidative damage after s... | To our knowledge, this is the first study demonstrating that hypothermia attenuates oxidative stress after severe TBI in infants and children. Our data also support the concept that CSF represents a valuable tool for monitoring treatment effects on oxidative stress after TBI. | yes |
19,091,619 | Do [ Diagnostic and treatment delays modify the treatment outcome of patients with multiform glioblastoma ]? | {
"contexts": [
"To assess waiting time effect in patient with multiform glioblastoma (GBM) treated with 3D conformal planned postoperative radiotherapy and to investigate the impact of chemotherapy as first adjuvant treatment.",
"We retrospectively analyzed 94 consecutive patients with histologically proven ... | In our series neither waiting times nor adjuvant immediate chemotherapy were prognosticator of local control and overall survival outcome of patients with glioblastoma. | no |
19,085,729 | Does [ CT scan increase rotational accuracy in total knee arthroplasty ]? | {
"contexts": [
"Several studies have shown that the rotation of the femoral component is an essential factor in total knee replacement. Consequently, different intra-operative landmarks for femoral implantation were established but most of them are either hard to define or have a high variance, so reducing their... | Preoperative measurement of the posterior condylar angle was proven to be a simple, reproducible examination method which increases the rotational accuracy of total knee replacement. | yes |
19,091,791 | Does ets-1 mediate platelet-derived growth factor-BB-induced thrombomodulin expression in human vascular smooth muscle cells? | {
"contexts": [
"Thrombomodulin (TM), a potent anticoagulant, is not detected in quiescent vascular smooth muscle cells (VSMCs). In diseased vessels, VSMC expresses TM, but the mechanisms are unclear. This study examined molecular mechanisms for TM expression in VSMCs.",
"Platelet-derived growth factor-BB (PD... | In VSMCs, PDGF-BB stimulates TM expression that is mainly mediated by Ets-1 via the Src kinase/PI3-kinase/Akt/mTOR signalling pathway. Furthermore, PDGF-BB may regulate TM expression in VSMCs during vascular remodelling. | yes |
19,095,215 | Is accurate axillary lymph node dissection feasible after neoadjuvant chemotherapy? | {
"contexts": [
"Recently, lower axillary lymph node retrieval after neoadjuvant chemotherapy was reported. We did not have this experience, and retrospectively analyzed our axillary lymph node dissections (ALNDs).",
"One hundred ninety-one patients who had ALND after neoadjuvant chemotherapy were compared wi... | Our results show the feasibility and need to remove enough lymph nodes to provide precise prognostic information and adequate local control. | yes |
19,095,219 | Is variation in catechol-O-methyltransferase associated with duloxetine response in a clinical trial for major depressive disorder? | {
"contexts": [
"The study objective was to evaluate variations in genes implicated in antidepressant mechanism of action for association with response to duloxetine treatment in major depressive disorder (MDD).",
"We assessed response over 6 weeks in 250 duloxetine-treated Caucasian patients in a randomized,... | Single nucleotide polymorphisms in COMT were associated with symptom change in duloxetine-treated patients with MDD. If replicated, the magnitude of the COMT genotype effect is of clinical relevance. | yes |
19,086,452 | Is remnant lipoprotein cholesterol homogenous assay ( RemL-C ) closely associated with very-low-density lipoprotein remnants : comparison with the immunoseparation assay? | {
"contexts": [
"Remnant-like particle-cholesterol (RLP-C) is recognized as a risk factor for cardiovascular disease. As an alternative to the immunoseparation assay widely used for the measurement of RLP-C, a new remnant lipoprotein-C homogenous assay (RemL-C) is available. In light of its homogeneity as an assa... | The remnant lipoprotein cholesterol homogenous assay is more closely associated with VLDL2 and IDL than the immunoseparation assay. | yes |
19,095,111 | Is low sensitivity of physical examination findings in necrotizing soft tissue infection improved with laboratory values : a prospective study? | {
"contexts": [
"When clinical \"hard signs\" of necrotizing soft tissue infection (NSTI) are present, establishing the diagnosis of NSTI is not difficult. However, hard signs of NSTIs are often absent on presentation, thus potentially delaying diagnosis and surgical intervention. A prior retrospective study perf... | Fewer than half of the patients presented with hard clinical signs of NSTI. Admission WBC count >15,400/microL or serum Na <135 mEq/L significantly increased suspicion for NSTI and aided early diagnosis. | yes |
19,099,709 | Do [ Detection of fusion genes in childhood acute lymphoblastic leukemia by using oligonucleotide microarrays approach ]? | {
"contexts": [
"To evaluate the possibility of applying oligonucleotide microarrays for detection of the fusion genes in childhood acute lymphoblastic leukemia (ALL).",
"To detect five types of fusion genes emerging frequently in childhood ALL including TEL/AML1, E2A/PBX1, BCR/ABLp190, BCR/ABLp210, MLL/AF4, ... | The microarray-based assay could screen 5 types of chromosome structural aberrations and the splice variants at the same time. It can provide reliable and helpful information for patient stratification, evaluation of therapeutic effects and prediction of prognosis in childhood ALL, although there are both advantages an... | yes |
19,088,158 | Is increased production of 17beta-estradiol in endometriosis lesions the result of impaired metabolism? | {
"contexts": [
"substantial evidence suggests that the expression of steroid metabolizing enzymes in endometriosis is altered, turning the ectopic endometrium into a source of 17beta-estradiol. However, whether these differences result in a net increase in local 17beta-estradiol production/activity has not been ... | Endometriotic lesions have higher production of 17beta-estradiol than the eutopic endometrium of patients and controls. This is mostly the result of impaired metabolism. | yes |
19,094,177 | Does tezosentan normalize hepatomesenteric perfusion in a porcine model of cardiac tamponade? | {
"contexts": [
"To investigate endothelin-1 (ET-1)-dependent hepatic and mesenteric vasoconstriction, and oxygen and lactate fluxes in an acute, fixed low cardiac output (CO) state.",
"Sixteen anesthetized, mechanically ventilated pigs were studied. Cardiac tamponade was established to reduce portal venous b... | In a porcine model of acute splanchnic hypoperfusion, unselective ET-1 blockade restored hepatomesenteric perfusion and reversed lactate metabolism. These observations might be relevant when considering liver protection in low CO states. | yes |
19,109,799 | Do liver dysfunction and sepsis determine operative mortality after liver resection? | {
"contexts": [
"Liver failure is the principal cause of death after hepatectomy. Its progression towards death and its relationship with sepsis are unclear. This study analysed predictors of mortality in patients with liver dysfunction and the role of sepsis in the death of these patients.",
"The study focus... | Sepsis plays a key role in the death of patients with liver dysfunction after hepatectomy. Early recognition and aggressive treatment of sepsis may reduce mortality. | yes |
19,106,647 | Is microRNA miR-155 a biomarker of early pancreatic neoplasia? | {
"contexts": [
"Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursor lesions of pancreatic cancer. Misexpression of microRNAs (miRNAs) is commonly observed in pancreatic adenocarcinoma. In contrast, miRNA abnormalities in pancreatic cancer precursor lesions have not been documented.",
... | Aberrant miRNA expression is an early event in the multistage progression of pancreatic cancer, and miR-155 warrants further evaluation as a biomarker for IPMNs in clinical samples. | yes |
19,093,007 | Does a novel mutation in BBS7 gene cause Bardet-Biedl syndrome in a Chinese family? | {
"contexts": [
"To describe the clinical features of and identify a novel mutation in Bardet-Biedl syndrome 7 gene (BBS7) in a Chinese family.",
"Nineteen individuals at risk for inheriting Bardet-Biedl syndrome (BBS) in a Chinese family participated in the study. Physical examination was performed and blood... | This study describes a novel mutation in BBS7 causing BBS in a Chinese family. This is the first report that a mutation in a BBS gene causes BBS in a Chinese population. These results expand the spectrum of human disease associated with mutations of BBS7 since the initial three mutations in BBS7 were first identified i... | yes |
19,093,002 | Is cB1 expression attenuated in Fallopian tube and decidua of women with ectopic pregnancy? | {
"contexts": [
"Embryo retention in the Fallopian tube (FT) is thought to lead to ectopic pregnancy (EP), a considerable cause of morbidity. In mice, genetic/pharmacological silencing of cannabinoid receptor Cnr1, encoding CB1, causes retention of embryos in the oviduct. The role of the endocannabinoids in tubal... | CB1 mRNA shows temporal variation in expression in human FT, likely regulated by progesterone. CB1 mRNA is expressed in low levels in both the FT and endometrium of women with EP. We propose that aberrant endocannabinoid-signaling in human FT leads to EP. Furthermore, our finding of reduced mRNA expression along with a... | yes |
19,103,735 | Is angiotensin II type 1 receptor expression increased via 12-lipoxygenase in high glucose-stimulated glomerular cells and type 2 diabetic glomeruli? | {
"contexts": [
"Angiotensin II type 1 receptor (AT1) plays an important role in the development of diabetic nephropathy (DN). However, the roles played by 12-lipoxygenase (12-LO) in the AT1 expression in glomerular cells exposed to high glucose (HG) and diabetic glomeruli remain unclear. Our objective in the pre... | These results indicate that AT1 expression is enhanced, at least in part, by 12-LO in the type 2 diabetic glomeruli, and 12-LO inhibition can ameliorate DN progression through downregulation of AT1 expression. | yes |
19,108,727 | Does ephrin-B2 expression critically influence Nipah virus infection independent of its cytoplasmic tail? | {
"contexts": [
"Cell entry and cell-to-cell spread of the highly pathogenic Nipah virus (NiV) requires binding of the NiV G protein to cellular ephrin receptors and subsequent NiV F-mediated fusion. Since expression levels of the main NiV entry receptor ephrin-B2 (EB2) are highly regulated in vivo to fulfill the... | Our findings clearly show that EB2 signaling does not account for the striking negative impact of elevated receptor expression on NiV infection, but rather that the ratio between the NiV envelope glycoproteins and surface receptors critically influence cell-to-cell fusion and virus entry. | yes |
19,102,806 | Is monetary cost of dietary energy negatively associated with BMI and waist circumference , but not with other metabolic risk factors , in young Japanese women? | {
"contexts": [
"Little is known about the relationship of dietary cost to health status. The present cross-sectional study examined the association between the monetary cost of dietary energy (Japanese yen/4184 kJ) and several metabolic risk factors.",
"Monetary cost of dietary energy was estimated based on ... | The monetary cost of dietary energy was independently and negatively associated with both BMI and waist circumference, but not other metabolic risk factors, in a group of young Japanese women. | yes |
19,108,738 | Is haptoglobin phenotype a predictor of recurrence free survival in high-risk primary breast cancer patients? | {
"contexts": [
"Better breast cancer prognostication may improve selection of patients for adjuvant therapy. We conducted a retrospective follow-up study in which we investigated sera of high-risk primary breast cancer patients, to search for proteins predictive of recurrence free survival.",
"Two sample set... | In contrast to our initial results, the haptoglobin phenotype was not identified as a predictor of recurrence free survival in high-risk primary breast cancer in our validation set. Our initial observation in the discovery set was probably the result of a type I error (i.e. false positive). This study illustrates the i... | no |
19,108,733 | Is histone H1x highly expressed in human neuroendocrine cells and tumours? | {
"contexts": [
"Histone H1x is a ubiquitously expressed member of the H1 histone family. H1 histones, also called linker histones, stabilize compact, higher order structures of chromatin. In addition to their role as structural proteins, they actively regulate gene expression and participate in chromatin-based p... | We conclude that the high expression of histone H1x in NETs is probably due to the abundance of this protein in the cells from which these tumours originate. | yes |
19,107,207 | Does global expression profiling in atopic eczema reveal reciprocal expression of inflammatory and lipid genes? | {
"contexts": [
"Atopic eczema (AE) is a common chronic inflammatory skin disorder. In order to dissect the genetic background several linkage and genetic association studies have been performed. Yet very little is known about specific genes involved in this complex skin disease, and the underlying molecular mech... | Through genome-wide expression profiling, we were able to discover a distinct reciprocal expression pattern of induced inflammatory genes and repressed lipid metabolism genes in skin from AE patients. We found a significant enrichment of differentially expressed genes in AE with cytobands associated to the disease, and... | yes |
19,099,240 | Does cholecystokinin secretion induced by beta-conglycinin peptone depend on Galphaq-mediated pathways in enteroendocrine cells? | {
"contexts": [
"Intraduodenal administration of peptone prepared from soybean beta-conglycinin (BconP) stimulates cholecystokinin (CCK) secretion from enteroendocrine cells, and suppresses food intake in rats. However, the sensing mechanism of BconP by CCK-producing cells is unknown.",
"We investigated signa... | These results indicate that Galphaq pathway is responsible for BconP-induced CCK secretion in STC-1 cells, and suggest the involvement of a Galphaq-coupled GPCR(s) in dietary peptide sensing in enteroendocrine cells. | yes |
19,105,208 | Does liver X receptor mediate hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma? | {
"contexts": [
"Although hepatitis B virus X protein (HBx) has been implicated in abnormal lipid metabolism in hepatitis B virus (HBV)-associated hepatic steatosis, its underlying molecular mechanism remains unclear. Liver X receptor (LXR) plays an important role in regulating the expression of genes involved in... | Our results suggest a novel association between HBx and LXR that may represent an important mechanism explaining HBx-induced hepatic lipogenesis during HBV-associated hepatic carcinogenesis. | yes |
19,105,206 | Is foxl1 a marker of bipotential hepatic progenitor cells in mice? | {
"contexts": [
"The liver contains a population of small bipotential facultative progenitor cells that reconstitute liver function when mature hepatocytes or cholangiocytes are unable to proliferate. Mesenchymal markers, including members of the forkhead transcription factor gene family, have been detected in he... | We propose that Foxl1 is a bona fide marker of the facultative progenitor cell in the mouse liver. | yes |
19,087,571 | Does [ Suppression of WWOX gene by RNA interference reverse platinum resistance acquired in SKOV3/SB cells ]? | {
"contexts": [
"To assess the suppression effect on WWOX gene in SKOV3/SB cell line by small interference RNA (siRNA).",
"Transfection of siRNA using lipofectamine 2000 was conducted to silence WWOX gene expression, the expression levels of WWOX mRNA and protein were evaluated, and the effects on the cell cy... | WWOX gene may be involved in cisplatin resistance phenomenon in epithelial ovarian cancer. | yes |
19,091,128 | Does human immunodeficiency virus type-1 reverse transcriptase exist as post-translationally modified forms in virions and cells? | {
"contexts": [
"HIV-1 reverse transcriptase (RT) is a heterodimer composed of p66 and p51 subunits and is responsible for reverse transcription of the viral RNA genome into DNA. RT can be post-translationally modified in vitro which may be an important mechanism for regulating RT activity. Here we report detecti... | The same major isoform of p66 and p51 RT is found in virions, infected cells and RTC's and both of these subunits are post-translationally modified. This post-translational modification of RT may be important for the function of RT inside the cell. | yes |
19,109,741 | Does platonin inhibit LPS-induced NF-kappaB by preventing activation of Akt and IKKbeta in human PBMC? | {
"contexts": [
"Platonin is a potent macrophage-activating agent and an immunomodulator. It has been used to treat trauma, ulcers and some acute inflammations. Although platonin has desirable anti-inflammatory effects, its mechanism of action is not clear. In the present study, we investigated the effect of lipo... | These results suggest the anti-inflammatory activity of platonin is a result of reduced NF-kappaB activity due to inhibition of Akt and IKKbeta. | yes |
19,109,743 | Is hydrogen sulphide pro-inflammatory in haemorrhagic shock? | {
"contexts": [
"H(2)S is pro-inflammatory in inflammatory models, thus we investigated whether H(2)S plays a role in haemorrhagic shock (HS)-associated inflammation.",
"Male, Sprague-Dawley rats were given an inhibitor of H(2)S biosynthesis, DL-propargylglycine (PAG, 50 mg/kg, i. v.) or saline (1 ml/kg) 30 m... | H(2)S is pro-inflammatory in HS and inhibition of H(2)S biosynthesis may reduce some HS-induced inflammatory responses and organ injury. | yes |
19,109,744 | Do digoxin and digoxin-like immunoreactive factors ( DLIF ) modulate the release of pro-inflammatory cytokines? | {
"contexts": [
"Cardiac glycosides such as digoxin and their endogenous counterpart digoxin-like immunoreactive factor (DLIF) may possess anti-inflammatory properties.",
"Pro-inflammatory cytokines from human peripheral blood mononuclear cells (PBMC) were measured by ELISA using specific antibodies. Immunocy... | Digoxin and DLIF inhibit the release of proinflammatory cytokines from PBMC via NF-K: B-dependent pathway suggesting an anti-inflammatory effect. | yes |
19,086,279 | Is clostridium difficile-associated diarrhea with hematochezia associated with ulcer formation? | {
"contexts": [
"Clostridium difficile-associated diarrhea (CDAD) is a well-known iatrogenic infection with typical endoscopic features including pseudomembranes and intervening normal mucosa. Clinically, diarrhea frequently occurs, but occurrence of hematochezia is rare. The objective of this study was to invest... | CDAD accompanied by hematochezia is closely associated with ulcer formation. Ulcers are thought to occur during recovery from nadir after anticancer treatment, and white blood cells appear to be essential for their formation. Physicians should therefore pay close attention to the occurrence of colonic ulcer, especially... | yes |
19,112,165 | Does platelet activation by low concentrations of intact oxidized LDL particles involve the PAF receptor? | {
"contexts": [
"Mitochondrial depolarization aids platelet activation. Oxidized LDL (oxLDL) contains the medium length oxidatively truncated phospholipid hexadecyl azelaoyl-lysoPAF (HAz-LPAF) that disrupts mitochondrial function in nucleated cells, so oxLDL may augment platelet activation.",
"Flow cytometry ... | Intact oxLDL particles activate platelets through the PAF receptor, and the PAF receptor responds to a far wider range of oxidized phospholipids in oxLDL than anticipated. | yes |
19,112,163 | Is angiopoietin-2 exocytosis stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells? | {
"contexts": [
"Although diverse functions of angiopoietin-2 (Ang2) have been revealed, little is known about upstream signaling molecules regulating Ang2 exocytosis. We therefore investigated the mechanism of Ang2 exocytosis in human blood and lymphatic endothelial cells (BECs and LECs) by stimulation with sphi... | These results imply that the rapid secretion of Ang2 by exocytosis from endothelial cells is another possible mechanism underlying S1P-induced angiogenesis and inflammation. | yes |
19,098,205 | Do traditional clinical risk assessment tools accurately predict coronary atherosclerotic plaque burden : a CT angiography study? | {
"contexts": [
"The objective of our study was to determine the degree to which Framingham risk estimates and the National Cholesterol Education Program (NCEP) Adult Treatment Panel III core risk categories correlate with total coronary atherosclerotic plaque burden (calcified and noncalcified) as estimated on c... | Coronary risk stratification using a risk factor only-based scheme is a weak discriminator of the overall atherosclerotic plaque burden in individual patients. Patients with little or no plaque might be subjected to lifelong drug therapy, whereas many others with substantial plaque might be undertreated or not treated ... | no |
19,107,684 | Do early post operative visual outcome in microsurgically treated suprasellar meningiomas predict long-term visual outcome? | {
"contexts": [
"Different data exist regarding long-term visual prognosis associated with suprasellar meningiomas. The aim of this study was to determine the outcome of suprasellar meningiomas with respect to short and long-term visual outcomes.",
"During the period of 1997 to 2006, 45 patients were operated... | Visual outcome is better in patients with preoperative vision > 1 mfc and early post-operative vision significantly correlates with long term visual outcome. | yes |
19,103,360 | Are narrowband ultraviolet B and medium-dose ultraviolet A1 equally effective in the treatment of moderate to severe atopic dermatitis? | {
"contexts": [
"Phototherapy may be effective in atopic dermatitis (AD). Medium-dose (MD) ultraviolet (UV) A1 was introduced for the treatment of AD. Few immunohistochemical data are available pertaining to phototherapy in AD. Regulatory T cells may play a role in clearing AD.",
"We sought to compare the cli... | MD UVA1 therapy was given 3 times per week instead of the preferred regimen of 5 times per week. This was necessary to achieve good blinding of the study. | yes |
19,092,699 | Does exercise affect platelet-impeded antitumor cytotoxicity of natural killer cell? | {
"contexts": [
"Natural killer cells (NK) induce the death of tumor cells by perforin/granzyme-mediated cytotoxicity, whereas platelets reduce the capacity of NK to destroy tumor cells. Physical exercise affects both immune function and platelet activity because responses depend on type, intensity, and duration ... | Severe exercise enhances the cytotoxicity of NK to NPC and simultaneously promotes the platelet-impeded apoptosis of NPC induced by NK. However, warm-up exercise reduces the resistance of platelet to NK-NPC interaction, increasing the efficiency of anti-NPC cytotoxicity by NK after severe exercise. | yes |
19,092,694 | Does protein modification respond to exercise intensity and antioxidant supplementation? | {
"contexts": [
"To assess the effects of different exercise intensities and antioxidant supplementation on plasma protein modification.",
"Trained men (n = 41) from a homogenous population were randomly assigned to perform cycle ergometer exercise either at 70% or 80% of individual .VO2max. Each intensity gr... | These results indicate that CP concentrations increase with 80% .VO2max intensity. The JPC group had lower baseline CP levels after 16 and 28 wk and no exercise-induced CP increase. HSA is reversibly shifted to a more oxidized state by recent intense exercise. | yes |
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