pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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|---|---|---|---|---|
25,972,525 | Does expression of Selenoprotein Genes be Affected by Obesity of Pigs Fed a High-Fat Diet? | {
"contexts": [
"Relations of the 25 mammalian selenoprotein genes with obesity and the associated inflammation remain unclear.",
"This study explored impacts of high-fat diet-induced obesity on inflammation and expressions of selenoprotein and obesity-related genes in 10 tissues of pigs.",
"Plasma and 10... | The high-fat diet induced inflammation in pigs and affected their gene expression of selenoproteins associated with thioredoxin and oxidoreductase systems, local tissue thyroid hormone activity, endoplasmic reticulum protein degradation, and phosphorylation of lipids. This porcine model may be used to study interactive... | yes |
25,972,522 | Does dietary Silicon Deficiency Exacerbate Diet-Induced Fatty Lesions in Female ApoE Knockout Mice? | {
"contexts": [
"Dietary silicon has been positively linked with vascular health and protection against atherosclerotic plaque formation, but the mechanism of action is unclear.",
"We investigated the effect of dietary silicon on 1) serum and aorta silicon concentrations, 2) the development of aortic lesions ... | These findings suggest that dietary silicon has no effect on atherosclerosis development and vascular health in the apoE mouse model of diet-induced atherosclerosis, contrary to the reported findings in the cholesterol-fed rabbit model. | no |
25,972,523 | Does midupper Arm Circumference outperform Weight-Based Measures of Nutritional Status in Children with Diarrhea? | {
"contexts": [
"Undernutrition contributes to 45% of all deaths in children <5 y of age worldwide, with a large proportion of those deaths caused by diarrhea. However, no validated tools exist for assessing undernutrition in children with diarrhea and possible dehydration.",
"This study assessed the validity... | MUAC and MUACZ were the most accurate predictors of undernutrition in children with diarrhea. WAZ and WLZ were significantly affected by dehydration status, leading to the misdiagnosis of many patients on arrival with severe underweight and SAM. This trial was registered at clinicaltrials.gov as NCT02007733. | yes |
25,961,465 | Are valid screening questions useful to diagnose hand and forearm eczema available in the Spanish language , a new tool for global research? | {
"contexts": [
"Hand eczema is an impacting cutaneous disease. Globally valid tools that help to diagnose hand and forearm eczema are required.",
"To validate the questions to detect hand and/or forearm eczema included in the \"Nordic Occupational Skin Questionnaire\" (NOSQ-2002) in the Spanish language.",
... | The questions validated detected eczema effectively, making this tool suitable for use e.g. in multicentre epidemiological studies or clinical trials. | yes |
25,958,858 | Is gPRC6a required for the effects of a high-protein diet on body weight in mice? | {
"contexts": [
"The G-protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low- and high-protein diets on body weight and ... | GPRC6A was not necessary for the effects of a low- or high-protein diet on body weight and likely does not play a role in protein-induced satiety. | no |
25,968,832 | Does cigarette Smoke modulate NOD1 Signal Pathway and Human β Defensins Expression in Human Oral Mucosa? | {
"contexts": [
"Nucleotide binding oligomerization domain 1 (NOD1) signal pathway and human β defensins (hBDs) play crucial roles in innate immune. Cigarette smoke has been confirmed to dampen innate immune in some human tissues, such as oral mucosa. The aim of this study was to evaluate potential effects of smo... | The present study indicated that cigarette smoke could potentially modulate the expression of crucial molecules of NOD1 signal pathway and hBDs in human oral mucosal epithelium. NOD1 signal pathway could play an important role in the regulatory effects of CSE on hBDs levels in oral mucosal epithelial cells. | yes |
25,959,209 | Do vitamin B12 and folate levels increase during treatment of iron deficiency anaemia in young adult woman? | {
"contexts": [
"The relationship between iron deficiency and vitamin B12 and folate was recognized several decades ago. Combined deficiency is important in clinical practice owing to its relationship with malabsorption syndromes. By contrast, iron deficiency and low levels of serum vitamin B12 with normal metabo... | Data from our work suggest that iron deficiency could affect many metabolic pathways, including vitamin B12, folate and lipids. These changes normalize after iron therapy, even in women with baseline low levels of serum vitamin B12. Healthcare practitioners should be aware of these changes in IDA management. The mechan... | yes |
25,960,005 | Do high plasma triglyceride levels strongly correlate with low kisspeptin in the arcuate nucleus of male rats? | {
"contexts": [
"It is well known that reproductive capacity is lower in obese individuals, but what mediators and signals are involved is unclear. Kisspeptin is a potent stimulator of GnRH release, and it has been suggested that kisspeptin neurons located in the arcuate nucleus transmit metabolic signals to the ... | We find a strong negative correlation between plasma triglyceride concentrations and the number of kisspeptin neurons in the rat arcuate nucleus regardless of the percentage of fat in the diet. In line with the lipotoxicity hypothesis, our results suggest that it is the level of hypertriglyceridemia per se that is a de... | yes |
25,986,700 | Are tissue inflammation and nitric oxide-mediated alterations in cardiovascular function major determinants of endotoxin-induced insulin resistance? | {
"contexts": [
"Endotoxin (i.e. LPS) administration induces a robust inflammatory response with accompanying cardiovascular dysfunction and insulin resistance. Overabundance of nitric oxide (NO) contributes to the vascular dysfunction. However, inflammation itself also induces insulin resistance in skeletal musc... | Nitric oxide excess and LPS impairs glycemic control by diminishing MGU. LPS impairs MGU by both the direct effect of inflammation on the myocyte, as well as by the indirect NO-driven cardiovascular dysfunction. | yes |
25,983,214 | Do human Tear Serotonin Levels Correlate with Symptoms and Signs of Dry Eye? | {
"contexts": [
"Serotonin, a neurotransmitter known to be involved in nociceptor sensitization, is present in human tears. The purpose of this study was to correlate tear serotonin levels, as a marker of nociceptor sensitization, to facets of dry eye (DE), including symptoms and signs.",
"Cross-sectional stu... | Patients with DE symptoms and aqueous tear deficiency had higher tear serotonin levels compared with those with DE symptoms but normal tear production and those without DE symptoms. | yes |
25,975,496 | Does trigonelline protect the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells? | {
"contexts": [
"To elucidate the key parameters associated with hydrogen peroxide induced oxidative stress and investigates the mechanism of trigonelline (TG) for reducing the H2O2 induced toxicity in H9c2 cells.",
"Cytotoxicity and antioxidant activity of TG was assessed by EZ-CYTOX kit. RNA extraction and ... | It is suggested that less than 125 μ M of TG could protect the cells from H2O2 induced cell damage by down regulating the caspases and up regulating the Bcl-2 and Bcl-XL expression. Therefore, we suggest the trigonelline could be useful for treatment of oxidative stress mediated cardiovascular diseases in future. | yes |
25,975,498 | Does monascus pilosus-fermented black soybean inhibit lipid accumulation in adipocytes and in high-fat diet-induced obese mice? | {
"contexts": [
"To explore the anti-obesity effects and the mechanism of action of Monascus pilosus(M. pilosus)-fermented black soybean (MFBS) extracts (MFBSE) and MFBS powders (MFBSP) in adipocytes and high-fat diet (HFD)-induced obese mice, respectively.",
"Black soybean was fermented with M. pilosus, and ... | These results suggest that the anti-obesity effects of MFBS are elicited by regulating the expression of adipogenesis-related genes in adipocytes and WAT of HFD-induced obese mice. | yes |
25,986,336 | Is the duration of cardiopulmonary resuscitation in emergency departments after out-of-hospital cardiac arrest associated with the outcome : A nationwide observational study? | {
"contexts": [
"The appropriate duration of cardiopulmonary resuscitation (CPR) for patients who experience out-of-hospital cardiac arrest (OHCA) remains unknown. This study aimed to evaluate the duration of CPR in emergency departments (EDs) and to determine whether the institutions' median duration of CPR was ... | The duration of CPR varied widely among hospitals. The institutional duration of CPR less than 20 min was significantly associated with lower survival-to-discharge rate. | yes |
25,977,378 | Does monoclonal antibody against transforming growth factor Beta 1 influence liver regeneration after resection in large animal experiments? | {
"contexts": [
"Steatohepatitis is a type of histopathological liver injury that can be caused by chemotherapy [chemotherapy-associated steatohepatitis (CASH)] and can progress to liver fibrosis or cirrhosis. CASH impairs liver functions, including liver regeneration. Impaired liver regeneration reduces the numb... | We established a large animal model of toxic liver injury that is comparable with CASH. The toxic injury that was induced without pause between administrations was probably more extensive than occurs in CASH, and there was no effect of MAB-TGFβ administration on liver regeneration. MAB-TGFβ administration did not lead ... | no |
25,960,225 | Does miR-20a mediate temozolomide-resistance in glioblastoma cells via negatively regulating LRIG1 expression? | {
"contexts": [
"Resistance to temozolomide (TMZ) is a major obstacle in the treatment of glioblastoma multiforme (GBM). MiRNAs is considered as an important modulator of drug resistance in many cancers. Here, we aimed to elucidate the relationship between miR-20a, its predicted target genes leucine-rich repeats ... | MiR-20a mediated TMZ-resistance in glioblastoma cells through negatively regulating LRIG1 expression, which suggesting that miR-20a and LRIG1 would be potential therapeutic targets for glioma therapy. | yes |
25,968,058 | Does olfactory Function Assessment of Blind Subjects Using the Sniffin ' stick Test? | {
"contexts": [
"In recent years, a growing number of studies have focused on the olfactory abilities of blind individuals as well as their tactile and auditory senses. In this study, we aimed to investigate possible alterations in the sense of smell in early- and late-blind subjects as compared with sighted cont... | This finding may suggest that odor discrimination and odor threshold in blind people were superior to those of controls. There was no difference in any of the results of tasks among congenital and acquired blind subjects. | yes |
25,977,924 | Do functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer? | {
"contexts": [
"This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer.",
"Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of r... | Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and -765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation. | yes |
25,980,035 | Do human CD8+ T-Cell Responses Against the 4 Dengue Virus Serotypes Are Associated With Distinct Patterns of Protein Targets? | {
"contexts": [
"All 4 dengue virus (DENV) serotypes are now simultaneously circulating worldwide and responsible for up to 400 million human infections each year. Previous studies of CD8(+) T-cell responses in HLA-transgenic mice and human vaccinees demonstrated that the hierarchy of immunodominance among struct... | This study provides new insight into differential serotype-specific immunogenicity of DENV proteins. It further provides a potentially valuable tool for future investigations of CD8(+) T-cell responses in the typically small sample volumes available from patients with acute fever and children without requiring prior kn... | yes |
25,986,676 | Does deletion of the Serotonin Receptor Type 3A in Mice lead to Sudden Cardiac Death During Pregnancy? | {
"contexts": [
"The serotonin receptor type 3 (Htr3) blocker is associated with QT prolongation and torsades de pointes. However, little is known about effects of Htr3 on the heart arrhythmia.",
"An electrophysiological study Involving knock-out (KO) female mice lacking functional Htr3a (Htr3a(-/-)) and thei... | Htr3a is present in mouse hearts. Serotonin and Tph1 were increased during pregnancy. The deletion of Htr3a was related to fatal arrhythmias and sudden cardiac death during pregnancy, and its activation reversed the QT prolongation. | yes |
25,987,067 | Is recent Decrease in Colorectal Cancer Mortality Rate Affected by Birth Cohort in Korea? | {
"contexts": [
"Colorectal cancer mortality has started to decrease in several developed countries in Asia. The current study aimed to present the long-term trends in colorectal cancer mortality in Korea using joinpoint analysis and age-period-cohort modeling.",
"The number of colorectal cancer deaths and th... | Our study showed a recent decreasing trend in colorectal cancer mortality in women and a stable trend in men after 2003-2004. These changes in colorectal cancer mortality may be attributed to birth cohort effects. | yes |
25,959,635 | Are small studies more heterogeneous than large ones : a meta-meta-analysis? | {
"contexts": [
"Between-study heterogeneity plays an important role in random-effects models for meta-analysis. Most clinical trials are small, and small trials are often associated with larger effect sizes. We empirically evaluated whether there is also a relationship between trial size and heterogeneity (τ).",... | Heterogeneity between small studies is larger than between larger studies. The large imprecision with which τ is estimated in a typical small-studies' meta-analysis is another reason for concern, and sensitivity analyses are recommended. | yes |
25,958,302 | Does perinatal Inhibition of NF-KappaB have Long-Term Antihypertensive and Renoprotective Effects in Fawn-Hooded Hypertensive Rats? | {
"contexts": [
"Inhibition of transcription factor nuclear factor-kappa B (NFκB) is beneficial in various models of hypertension and renal disease. We hypothesized first that NFκB inhibition during renal development ameliorates hereditary hypertensive renal disease and next whether this was mediated via suppress... | Perinatal inhibition of enhanced active renal NFκB in 2-day FHH had persistent antihypertensive and renoprotective effects. However, this was not the case for PPARγ stimulation. NFkB stimulation is therefore involved in renal damage in the FHH model of proteinuric renal disease by pathways other than via PPARγ. | yes |
25,973,090 | Is down-regulation of microRNA-124 correlated with tumor metastasis and poor prognosis in patients with lung cancer? | {
"contexts": [
"MicroRNA-124 (miR-124) has been proven dysregulated in several human malignancies and correlated with tumor progression. However, its expression and clinical significance in non-small cell lung cancer (NSCLC) is still unclear. Thus, the aim of this study was to investigate the clinical significan... | Our results offer the convincing evidence that miR-124 may play key roles in the progression of lung cancer and that the down-regulated expression of miR-124 may be independently associated with shorter OS and DFS of patients, suggesting that miR-124 might be a potential marker for further risk stratification in the tr... | yes |
25,973,098 | Are polymorphisms in the DUSP10 gene associated with sex-specific colorectal cancer risk in a Han population? | {
"contexts": [
"Colorectal cancer (CRC) is common, especially in developed countries. CRC is a multifactorial disease influenced by both environmental and genetic factors. In this study, we investigated the role of genetic polymorphisms in the dual specificity protein phosphatase 10 (DUSP10) gene especially in s... | Our findings suggest that DUSP10 polymorphisms influence the risk of developing CRC in Han Chinese and emphasize that sex should be considered in the design and analysis of health studies and biomedical research. | yes |
25,979,252 | Does optimal number of needle pass in endoscopic ultrasound-guided fine needle aspiration for pancreatic lesions? | {
"contexts": [
"Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is accurate in cytological diagnosis of pancreatic lesions. Our aim was to determine optimal number of needle passes in EUS-FNA for pancreatic lesions without onsite cytopathologist, who is not routinely available to participate in the... | Optimal numbers of needle passes in EUS-FNA for pancreatic lesions without onsite cytopathologist were between 1 and 3. | yes |
25,971,829 | Does the deep hypothermic circulatory arrest cause more kidney malfunctions based on a novel rabbit model? | {
"contexts": [
"High incidences of acute kidney injury after cardiopulmonary bypass (CPB) were observed in previous reports. However, whether deep hypothermic circulatory arrest (DHCA) leads to more severe kidney injury than CPB without DHCA remains controversial. The aim of the study was to investigate the effe... | Our study established a simple, convenient, economical, and long-term surviving rabbit model for the study of DHCA-induced organic injury. Based on more significant kidney injuries, including elevated levels of serum cystatin C and NGAL at an early time, increased lipid peroxidation, decreased renal antioxidative abili... | yes |
25,987,491 | Do heated jackets and dryland-based activation exercises used as additional warm-ups during transition enhance sprint swimming performance? | {
"contexts": [
"The lengthy competition transition phases commonly experienced by competitive swimmers may mitigate the benefits of the pool warm-up. To combat this, we examined the impact of additional passive and active warm-up strategies on sprint swimming performance.",
"Counterbalanced, repeated-measure... | Dryland-based exercise circuits completed alone and in combination with the application of heated tracksuit jackets during transition can significantly improve sprint swimming performance. Attenuation in the decline of core temperature and a reduction in start time appear as likely mechanisms. | yes |
25,971,982 | Does x-shaped DNA potentiate therapeutic efficacy in colitis-associated colon cancer through dual activation of TLR9 and inflammasomes? | {
"contexts": [
"Immunotherapy has been extensively pursed as a promising strategy for the treatment of cancer. Pattern-recognition receptors (PRRs) play important roles in triggering activation of innate and adaptive immunity. Therefore, agents that stimulate PRRs could be useful for cancer immunotherapy. We dev... | X-DNA induced the activation of dendritic cells as shown by the expression of immune-cytokines and co-stimulatory molecules, resulting in the differentiation of TH1 cells, mediated through dual activation of TLR9 and inflammasomes. X-DNA represents a promising immune adjuvant that can enhance the therapeutic efficacy o... | yes |
25,970,594 | Do impact of a moving noise masker on speech perception in cochlear implant users? | {
"contexts": [
"Previous studies investigating speech perception in noise have typically been conducted with static masker positions. The aim of this study was to investigate the effect of spatial separation of source and masker (spatial release from masking, SRM) in a moving masker setup and to evaluate the imp... | CI users showed SRM that was comparable to normal hearing subjects. In listening situations of everyday life with spatial separation of source and masker, directional microphones significantly improved speech perception with individual improvements of up to 15 dB SNR. Users of bilateral speech processors with both dire... | yes |
25,962,993 | Is minimally invasive Ivor-Lewis oesophagectomy a feasible and safe approach for patients with oesophageal cancer? | {
"contexts": [
"Minimally invasive approaches are increasingly being used in oesophagectomy. The aim of this study was to compare the short-term clinical outcomes of the minimally invasive Ivor-Lewis oesophagectomy (MIILE) technique with those of the open Ivor-Lewis oesophagectomy (OILE) technique.",
"We ide... | In this study, we demonstrate that MIILE is a feasible and safe approach for patients with middle or lower oesophageal cancer. | yes |
25,981,709 | Are peripheral conduit and resistance artery function improved following a single , 1-h bout of peristaltic pulse external pneumatic compression? | {
"contexts": [
"External pneumatic compression (EPC) is being employed for a widening range of clinical and non-clinical populations. However, EPC devices vary markedly in treatment pressures, duty cycles and application sites, and the acute effects of whole limb, lower pressure EPC on peripheral vascular functi... | Acutely, whole limb, lower pressure EPC improves conduit artery endothelial function systemically, but only improves RH blood flow locally (i.e., compressed limbs). | yes |
25,964,539 | Do epithelial-mesenchymal Transition ( EMT ) Markers in Human Pituitary Adenomas Indicate a Clinical Course? | {
"contexts": [
"Pituitary adenomas are brain tumors with invasive properties. Epithelial-mesenchymal-transition (EMT) is a cellular process linked to the transformation to an aggressive cancer phenotype. In the present study, we investigated the expression of a panel of EMT markers, namely E-cadherin, N-cadherin... | EMT markers are significant indicators of the appearance of cystic lesions, tumor progression, bone destruction and endocrine functions. These markers are valuable biomarkers in assessing the clinical course of pituitary adenomas. | yes |
25,964,533 | Does high-dose Ionizing Radiation regulate Gene Expression Changes in the MCF7 Breast Cancer Cell Line? | {
"contexts": [
"Intraoperative electron radiation therapy (IOERT) is a therapeutic technique which administers a single high dose of ionizing radiation immediately after surgical tumor removal. IOERT induces a strong stress response: both tumor and normal cells activating pro- and antiproliferative cell signalin... | In this study, we report genes and cellular networks activated following high-dose IOERT. The selected validated genes were used to design two descriptive models for each dose delivered. We believe that this study could contribute to the understanding over the complex mechanisms which regulate cell radiosensitivity and... | yes |
25,969,735 | Does cross-fostering immediately after birth induce a permanent microbiota shift that is shaped by the nursing mother? | {
"contexts": [
"Current research has led to the appreciation that there are differences in the commensal microbiota between healthy individuals and individuals that are predisposed to disease. Treatments to reverse disease pathogenesis through the manipulation of the gastrointestinal (GI) microbiota are now bein... | The results show that cross-fostering is an effective means to induce an early and maintained shift in the commensal microbiota. This will allow for the evaluation of a prolonged microbial shift and its effects on disease pathogenesis. Cross-fostering will also eliminate variation within control models by normalizing t... | yes |
25,987,094 | Are genetic Variants in ASCT2 Gene Associated with the Prognosis of Transarterial Chemoembolisation-Treated Early- Stage Hepatocelluar Carcinoma? | {
"contexts": [
"Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. Transarterial chemoembolisation (TACE) is the standardized therapy for intermediate stage HCC. However, the prognosis for HCC patients treated by TACE greatly varies. Thus, there is a critical need for finding bio... | We demonstrated that patients with early stage HCC carrying T genotype in rs2070246 showed better OS than those carrying CC genotype. | yes |
25,979,789 | Does the evidence speak for itself : The role of research evidence in shaping policy change for the implementation of publicly funded syringe exchange programs in three US cities? | {
"contexts": [
"A breadth of literature exists that explores the utilization of research evidence in policy change processes. From this work, a number of studies suggest research evidence is applied to change processes by policy change stakeholders primarily through instrumental, conceptual, and/or symbolic appl... | Typological applications of research evidence are useful for understanding policy change processes, but their efficacy falls short when sociopolitical factors complicate legislative processes. Advocates for harm reduction may benefit from understanding how to effectively integrate research evidence into policy change p... | no |
25,977,993 | Does variability of Automated Intraoperative ST Segment Values predict Postoperative Troponin Elevation? | {
"contexts": [
"Intraoperative electrocardiographic monitoring is considered a standard of care. However, there are no evidence-based algorithms for using intraoperative ST segment data to identify patients at high risk for adverse perioperative cardiac events. Therefore, we performed an exploratory study of sta... | Analysis of automated ST segment values obtained during anesthesia may be useful for improving the prediction of postoperative troponin elevation. | yes |
25,966,993 | Does pHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedite liver injury? | {
"contexts": [
"Endoplasmic reticulum (ER) stress is involved in liver injury, but molecular determinants are largely unknown. This study investigated the role of pleckstrin homology-like domain, family A, member-3 (PHLDA3), in hepatocyte death caused by ER stress and the regulatory basis.",
"Hepatic PHLDA3 ... | ER stress in hepatocytes induces PHLDA3 via IRE1-Xbp1s pathway, which facilitates liver injury by inhibiting Akt. | yes |
25,966,995 | Is the composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment altered in coeliac disease? | {
"contexts": [
"Coeliac disease (CD), a gluten-induced enteropathy, alters the composition and function of duodenal intraepithelial T cells. The intestine also harbours four types of CD3-negative intraepithelial lymphocytes (IELs) with largely unknown function: CD56(-)CD127(-), CD56(-)CD127(+), CD56(+)CD127(-) a... | Thus, we demonstrate previously unappreciated diversity and plasticity of the innate IEL compartment and its loss of differentiation potential in patients with RCDII. | yes |
25,987,191 | Do candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis? | {
"contexts": [
"Idiopathic scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide association studies have identified a number of common genetic variants that are significan... | Here, we confirm LBX1 as a susceptibility gene for idiopathic scoliosis in a Scandinavian population and report that we are unable to find evidence of other genes of similar or stronger effect. | yes |
25,974,998 | Does dATS suppress growth of esophageal squamous cell carcinoma by regulation of ERK1/2? | {
"contexts": [
"It is well known that garlics contain a large number of organosulfur compounds including diallyl trisulfide (DATS), which possess anticancer properties. However, the effects of DATS on esophageal squamous cell carcinoma (ESCC) growth are still poorly understood. In this study, we investigated the... | Our finding demonstrated that DATS inhibits the proliferation of ESCC cells by activation of ERK1/2 in vitro and in vivo. These findings revealed that DATS could be used for therapeutic intervention for human ESCC. | yes |
25,974,992 | Do neutrophil- and platelet-to-lymphocyte ratios are correlated with disease activity in rheumatoid arthritis? | {
"contexts": [
"Both neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are reported to be increased in various inflammation-related diseases, but their clinical significance in rheumatoid arthritis (RA) remains unclear. The aim of the present study was to explore whether NLR and PLR wer... | Both NLR and PLR values may prove to be potential indices for RA disease-activity assessment. | yes |
25,962,939 | Does miR-433 inhibit oral squamous cell carcinoma ( OSCC ) cell growth and metastasis by targeting HDAC6? | {
"contexts": [
"The aim of this study was to determine expression levels of miR-433 in oral squamous cell carcinomas (OSCCs) and adjacent normal tissues, and explore its biological functions in OSCCs.",
"miR-433 level in oral squamous cell carcinomas (OSCCs) and adjacent normal tissues was tested by real-tim... | Our data suggest that miR-433 exerts its tumor suppressor function by targeting HDAC6, leading to the inhibition of OSCC cell growth, invasion and migration, which suggest that miR-433 may be potential target for diagnostic and therapeutic applications in OSCC. | yes |
25,968,102 | Are osmophobia and allodynia critical factors for suicidality in patients with migraine? | {
"contexts": [
"Sensory hypersensitivities are common phenomena in migraine. We examined the role of sensory hypersensitivities on suicidality in patients with migraine.",
"Patients with migraine (with or without aura) were consecutively recruited from our headache clinic. We asked them if they experienced p... | Osmophobia and allodynia are critical factors for suicidality in patients with migraine, after controlling for depression, anxiety, and CM. | yes |
25,973,028 | Does myrtol ameliorate cartilage lesions in an osteoarthritis rat model? | {
"contexts": [
"The aim of this study is to evaluate the effects of myrtol standardized on cartilage lesions in osteoarthritis (OA) rats.",
"Fifty-six healthy Sprague-Dawley rats were randomly divided into sham group (13 rats) and OA model group (43 rats) with interior meniscus excision. Then serum estradiol... | Myrtol could down-regulate the expression of TNF-α, IL-6 and Bax, and up-regulate the expression of TGF-β1 and Bcl-2. Myrtol standardized is a promising drug to ameliorate knee cartilage lesions in the OA rat model. | yes |
25,959,105 | Is tumor necrosis factor-α expression in patients with obstructive benign prostatic hyperplasia associated with a higher incidence of asymptomatic inflammatory prostatitis NIH category IV and prostatic calcification? | {
"contexts": [
" The aim of this study was to investigate the association of the expression of tumor necrosis factor-α (TNF-α) with asymptomatic inflammatory prostatitis National Institutes of Health (NIH) category IV and prostatic calculi, in patients with obstructive benign prostatic hyperplasia (BPH) treated ... | In patients with obstructive BPH, prostatic calculi were found on ultrasound in one-third of the cases, and histological NIH category IV prostatitis in two-thirds of cases. The incidence of both prostatitis NIH category IV and TNF-α expression was significantly higher in patients with prostatic calculi than in those w... | yes |
25,980,983 | Does middle latency response correlate of single and double deviant stimuli in a multi-feature paradigm? | {
"contexts": [
"This study aimed to test single and double deviance-related modulations of the middle latency response (MLR) and the applicability of the optimum-2 multi-feature paradigm.",
"The MLR and the MMN to frequency, intensity and double-feature deviants of an optimum-2 multi-feature paradigm and the... | The optimum-2 multi-feature paradigm is suitable for recording double deviance-related modulations of the MLR. Interspersed intensity and frequency deviants in the standard trace of the optimum-2 condition multi-feature paradigm did not weaken the double MMN. | yes |
25,975,007 | Do dietary fatty acids affect lipid metabolism and estrogen receptor expression in N-methyl-N-nitrosourea-induced rat mammary cancer model? | {
"contexts": [
"We hypothesized that dietary polyunsaturated fatty acids (PUFA) could affect the expression of serum fatty acid binding protein 5 (FABP5) and CD36 levels and also fatty acid synthase (FAS), and estrogen receptor (ER) expressions in breast cancer cells.",
"A rat mammary cancer model was induce... | Our study showed that different dietary PUFAs may affect lipid metabolism in breast cancer tissues by altering the expression of FABP5, CD-36, FAS, and ER, which may change treatment response and even prognosis of breast cancer. | yes |
25,964,053 | Is chronic hyperglycemia associated with acute kidney injury in patients undergoing CABG surgery -- a cohort study? | {
"contexts": [
"Chronic hyperglycemia (CHG) with HbA1c as an indicator affects postoperative mortality and morbidity after coronary artery bypass grafting surgery (CABG). Acute kidney injury (AKI) is one of the frequent postoperative complications after CABG impacting short-and long-term outcomes. We investigate... | Our results suggest that CHG defined on a single measurement of HbA1c ≥ 6.0% was associated with the incidence of AKI after CABG. This finding might implicate that treatment decisions, including the selection of operative strategies, could be based on HbA1c measurement rather than on a recorded history of diabetes. | yes |
16,638,982 | Are extraocular muscle morphogenesis and gene expression regulated by Pitx2 gene dose? | {
"contexts": [
"PITX2 gene dose plays a central role in Axenfeld-Rieger syndrome. The purpose of this study was to test the hypothesis that the effects of Pitx2 gene dose on eye development can be molecularly dissected in available Pitx2 mutant mice.",
"A panel of mice with Pitx2 gene dose ranging from wild-... | Pitx2 gene dose regulates both morphogenesis and gene expression in developing extraocular muscles. The expression of key muscle-specific transcription factor genes is regulated by Pitx2 gene dose, suggesting that sufficient levels of PITX2 protein are essential for early initiation of the myogenic regulatory cascade i... | yes |
16,626,671 | Does i ( Kr ) contribute to the altered ventricular repolarization that determines long-term cardiac memory? | {
"contexts": [
"Cardiac memory (CM) is characterized by an altered T-wave morphology, which reflects altered repolarization gradients. We hypothesized that the delayed rectifier currents, I(Kr) and I(Ks), might contribute to these repolarization changes.",
"We studied conscious, chronically instrumented dogs... | A transcriptionally induced change in epicardial I(Kr) contributes to the altered ventricular repolarization that characterizes CM. | yes |
16,627,793 | Do nMDA receptor antibodies predict adverse neurological outcome after cardiac surgery in high-risk patients? | {
"contexts": [
"The goal of this study was to compare the predictive ability of S100B, N-methyl-D-aspartate (NMDA) receptor antibodies (NR2Ab) and C-reactive protein (CRP) for neurological deficits after cardiac surgery with cardiopulmonary bypass (CPB).",
"We investigated 557 high-risk adult patients who un... | Preoperative serum concentrations of NR2Ab, but not S100B or CRP, are predictive of severe neurological adverse events after CPB. Patients with a positive NR2Ab test (> or =2.0 ng/mL) preoperatively were nearly 18 times more likely to experience a postoperative neurological event than patients with a negative test (<2.... | yes |
16,648,019 | Does peptide YY attenuate STAT1 and STAT3 activation induced by TNF-alpha in acinar cell line AR42J? | {
"contexts": [
"STAT1 and STAT3, members of the cytoplasmic family of signal transducers and activators of transcription factors (STAT), have been associated with numerous inflammatory pathologies, including inflammatory bowel disease, hepatitis, and acute lung injury. But little is known about their role in the... | In pancreatic acinar cells, TNF-alpha activated STAT1 and STAT3, known mediators of inflammatory cytokines. Interestingly, PYY attenuated their protein/DNA binding, which may have an impact on development of the disease. Additional investigation of STAT proteins and PYY could provide new therapeutic strategies for panc... | yes |
16,650,464 | Are serine proteases HTRA1 and HTRA3 down-regulated with increasing grades of human endometrial cancer? | {
"contexts": [
"The high temperature requirement factor A (HTRA) family consists of serine proteases with domains homologous to those of bacterial HTRA. Four human HTRA members have been described: HTRA1-4. HTRA1 and HTRA3 share a high degree of domain homologies and may therefore share a functional similarity. ... | These data suggest that HTRA1 and HTRA3 mRNA and protein levels decrease with increasing grades of EC. | yes |
16,625,129 | Does extravascular lung water determined with single transpulmonary thermodilution correlate with the severity of sepsis-induced acute lung injury? | {
"contexts": [
"To find out if the extravascular lung water index (EVLWI) and the derived permeability indexes determined by the single transpulmonary thermodilution technique are associated with markers of acute lung injury in human septic shock.",
"Prospective, observational study.",
"Mixed intensive c... | In human septic shock, EVLWI demonstrated moderate correlation with markers of acute lung injury, such as lung compliance, oxygenation ratio, roentgenogram quadrants, and lung injury score. In nonsurvivors, EVLWI and permeability indexes were significantly increased at day 3. Thus, EVLWI might be of value as an indicat... | yes |
16,643,399 | Is progressive cardiac conduction defect the prevailing phenotype in carriers of a Brugada syndrome SCN5A mutation? | {
"contexts": [
"Loss-of-function mutations in the SCN5A gene encoding the cardiac sodium channel are responsible for Brugada syndrome (BS) and also for progressive cardiac conduction disease (inherited Lenègre disease). In an attempt to clarify the frontier between these two entities, we have characterized cardi... | The present study shows that the most common phenotype of gene carriers of a BS-type SCN5A mutation is progressive cardiac conduction defects similar to the Lenègre disease phenotype. In consequence, we propose that carriers of a SCN5A mutation need a clinical and ECG follow-up because of the risk associated with sever... | yes |
16,629,649 | Does tumor necrosis factor-a antisense transfer remarkably improve hepatic graft viability? | {
"contexts": [
"Cold ischemia/reperfusion injury of the hepatic graft, an unsolved problem in liver transplantations, is attributed to the release of inflammatory cytokines, especially the tumor necrosis factor- (TNF) alpha, from activated Kupffer cells (KC). Therefore, the specific inhibition of TNF-alpha could... | TNF-AS delivery improves the viability of the hepatic graft, and this technique may solve hepatic graft nonfunction in a clinical setting. | yes |
16,632,240 | Are soluble vascular cell adhesion molecule-1 and soluble E-selectin associated with micro- and macrovascular complications in Type 1 diabetic patients? | {
"contexts": [
"There are no large studies in Type 1 diabetic patients that have examined the relation between soluble adhesion molecules and micro- and macrovascular outcomes, although the risks of such complications are high. Therefore, the main objective is to examine the relationship between soluble (s) vasc... | In this large sample of Type 1 diabetic patients, it was shown that sVCAM-1 and sE-selectin have positive associations with retinopathy, albuminuria, and CVD. This suggests that adhesion molecules are important in the pathogenesis of vascular complications in Type 1 diabetes. | yes |
16,636,010 | Is pregabalin effective against behavioral and electrographic seizures during alcohol withdrawal? | {
"contexts": [
"Pregabalin has been shown to possess anticonvulsant, analgesic, and anxiolytic properties in a variety of testing situations. This study was designed to evaluate the ability of pregabalin to exert its anticonvulsant effects against behavioral and electrographic measures of CNS hyperexcitability a... | Collectively, these results suggest that pregabalin may be an effective therapeutic agent for medical management of alcohol detoxification. | yes |
16,630,147 | Is cysteinyl leukotriene receptor 1 promoter polymorphism associated with aspirin-intolerant asthma in males? | {
"contexts": [
"Cysteinyl leukotrienes (CysLTs) play important roles in the pathogenesis of eosinophilic airway inflammation characterized by bronchoconstriction, mucus secretion and airway hyper-responsiveness via cysteinyl leukotriene receptor 1 (CysLTR1)-mediated mechanism. CysLTR1-selective antagonists have ... | These results suggest that genetic variants of CysLTR1 are associated with AIA in a Korean population, and may modulate CysLTR1 expression. | yes |
16,631,201 | Do infected chronic wounds show different local and systemic arginine conversion compared with acute wounds? | {
"contexts": [
"Several experimental studies have shown the importance of arginine in wound healing. However, little is known about its role in human wound healing. In this study, we investigated arginine metabolism in impaired wound healing.",
"Twenty patients with chronic wounds and 10 patients with acute ... | This study demonstrates that patients with infected chronic wounds have decreased plasma arginine levels and suggests enhanced arginine conversion in the wound. In contrast to noninfected chronic wounds, arginine seems to be mainly metabolized by arginase in infected chronic wounds. In conclusion, our hypothesis is tha... | yes |
16,632,178 | Is focal S100A4 protein expression an independent predictor of development of metastatic disease in cystectomized bladder cancer patients? | {
"contexts": [
"The prognosis of patients with apparently localized, operable, muscle-invasive bladder cancer depends to a large extent on the presence or absence of subclinical, microscopic distant metastases at the time of surgery. Expression of the S100A4 protein has been shown to correlate with the risk of m... | There is a potential role for this marker in denoting patients with high or low risk of distant relapse independent of clinical stage and grade. | yes |
16,627,066 | Are c3a levels and occurrence of subdermal vascular thrombosis age-related in deep second-degree burn wounds? | {
"contexts": [
"After second-degree burns, thrombosis of the subdermal vascular plexus may occur, necessitating epifascial necrectomy instead of tangential excision to ensure split skin graft healing. Until now, no parameter has been obtained to explain this phenomenon.",
"Thirty-four patients with deep seco... | C3a is continuously elevated in deep second-degree burned wounds in patients > 60 years. This finding may be related to the occurrence of significantly more thrombotic blood vessels in deep dermal tissue of elderly patients. Microdialysis therapy is a useful tool to measure metabolic and immunologic parameters in therm... | yes |
16,627,061 | Is distribution of lymph node metastasis a prognostic index in patients with stage III colon cancer? | {
"contexts": [
"In the TNM classification of colorectal carcinoma, N-staging is dependent on the number of metastases; in the Japanese classification system, staging usually has been based on the distribution of metastases (N1, paracolic; N2, along the major vessels; N3, at the root of major vessels). The aim of... | This study suggests that adding the concept of nodal distribution to the conventional TNM staging of colon cancer will improve the accuracy in the evaluation of the nodal status. | yes |
16,630,910 | Do noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro? | {
"contexts": [
"Radiation therapy after surgical resection is the approved treatment of gliomas, and survival benefits are reported with taxane-based chemotherapy. We investigated whether these regimes could be augmented with blood-brain barrier permeable drugs, N and D. Noscapine is an opioid antitussive, which... | Noscapine and D should be further tested in animal models because of their potential and already-present clinical applicability. | yes |
16,645,460 | Is major histocompatibility complex haplotype associated with postherpetic pain in mice? | {
"contexts": [
"Postherpetic neuralgia is one of the major complications of herpes zoster caused by the reactivation of varicella-zoster virus and is characterized by severe pain. The authors previously showed the association of a human major histocompatibility complex (MHC) haplotype with postherpetic neuralgia... | These results suggest that the MHC haplotype (H-2) is involved in the incidence of postherpetic pain, and CD3-positive T cells may play a role in its pathogenesis. | yes |
16,647,329 | Do adolescents involved in weight-related and power team sports have better eating patterns and nutrient intakes than non-sport-involved adolescents? | {
"contexts": [
"To examine eating habits and energy and nutrient intake among adolescents participating in weight-related and power team sports and non-sport-involved adolescents.",
"Data were drawn from Project EAT (Eating Among Teens), which was conducted with 4,746 adolescents from 31 middle and high scho... | Sport-involved adolescents have better eating habits and nutrient intake than their non-sport-involved peers. However, they are still in need of nutrition interventions, particularly around calcium intake. | yes |
16,652,398 | Does inhibition of connective tissue growth factor by siRNA prevent liver fibrosis in rats? | {
"contexts": [
"Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in hepatic fibrogenesis. Small interfering RNA (siRNA) is an effective tool to silence gene expression post-transcriptionally. Therefore, we conducted an investigation to determine if intraportal vein siRNA injec... | Silencing CTGF expression with siRNA demonstrates therapeutic potential to prevent liver fibrosis by inhibiting HSC activation with consequent extracellular matrix accumulation and the upregulation of TGF-beta1 gene expression. | yes |
16,629,942 | Is a quantitative immunochemical faecal occult blood test more efficient for detecting significant colorectal neoplasia than a sensitive guaiac test? | {
"contexts": [
"The sensitive guaiac faecal occult blood test, Haemoccult SENSA (HOS; Beckman Coulter, Fullerton, CA, USA), is our standard screening test for significant colorectal neoplasia. We evaluated an automatically-developed, quantified human haemoglobin immunochemical faecal test, OC-MICRO (Eiken Chemic... | An immunochemical faecal test maintains the high sensitivity of guaiac faecal occult blood test, but significantly reduces the colonoscopy burden and screening costs. | yes |
16,646,977 | Does dense breast stromal tissue show greatly increased concentration of breast epithelium but no increase in its proliferative activity? | {
"contexts": [
"Increased mammographic density is a strong risk factor for breast cancer. The reasons for this are not clear; two obvious possibilities are increased epithelial cell proliferation in mammographically dense areas and increased breast epithelium in women with mammographically dense breasts. We addr... | Breast epithelial cells are overwhelmingly concentrated in high CT density areas. Their proliferation rate in areas of high and medium CT density is lower than that in low CT density areas. The increased breast cancer risk associated with increased mammographic densities may simply be a reflection of increased epitheli... | yes |
16,640,900 | Does [ Vitamin C reverse benzo ( a ) pyrene-induced cell cycle changes by E2F pathway ]? | {
"contexts": [
"To study the role of E2F1/4 pathway in vitamin C reversing benzo (a) pyrene [B (a) P]-induced changes of cell cycle in human embryo lung fibroblasts (HELF) and the relationship between E2F1 and cyclin D1/CDK4.",
"The stable transfectants, HELF transfected with antisense cyclin D1 and antisens... | Vitamin C might reserve the B (a) P-induced changes of cell cycle via intracellular signaling pathway of cyclin D1-CDK4/E2F-1/4. | yes |
16,637,912 | Do development of a stain shade guide to aid the measurement of extrinsic dental stain? | {
"contexts": [
"Accurate and reproducible assessment of extrinsic staining is pivotal to determining efficacy of some tooth whitening oral hygiene products. The aim of this study was: (1) to produce a stain shade guide to aid the in vitro and in vivo stain assessment (2) to assess intra- and inter-examiner repro... | The findings of this study would suggest that the use of the stain guide could be of importance in the assessment of extrinsic dental stain. | yes |
16,643,552 | Are platelet levels of dopamine increased in migraine and cluster headache? | {
"contexts": [
"To measure plasma and platelet levels of dopamine in patients with migraine with aura, migraine without aura, and cluster headache.",
"Clinical, genetic, and pharmacological evidences suggest that an abnormality of dopaminergic system plays a role in migraine pathogenesis. Direct evidence of ... | Our results support the hypothesis that the dopaminergic system is impaired in migraine and cluster headache and suggest that high platelet levels of dopamine may represent an abnormal biochemical phenotypic trait of these primary headaches. | yes |
16,643,554 | Is endocrine function altered in chronic migraine patients with medication-overuse? | {
"contexts": [
"To evaluate the effects of analgesic overuse on endocrine function in patients with chronic migraine and medication-overuse headache (CM-MOH).",
"Chronic migraine is frequently associated with an overuse of symptomatic medications. Drugs currently used in acute migraine attacks are associated... | Our study shows that both corticotropic and somatotropic functions are significantly impaired in CM-MOH patients and suggests a role for hormones in the development of chronic migraine. | yes |
16,637,898 | Are genes encoding bile acid , phospholipid and anion transporters expressed in a human fetal cardiomyocyte culture? | {
"contexts": [
"To establish a human fetal cardiomyocyte culture and to investigate whether the genes that encode transporters that may influence influx or efflux of bile acids are expressed in human fetal cardiomyocytes.",
"Laboratory study.",
"Imperial College London.",
"Six fetal hearts were obtai... | We have developed an in vitro model of the fetal heart that may be used for studies of the cardiac effect of endobiotics, e.g. bile acids, or of specific agents that may be used to treat the mother or fetus in pregnancy. | yes |
16,632,165 | Is the D2 dopamine receptor ( DRD2 ) gene associated with co-morbid depression , anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder? | {
"contexts": [
"To identify clusters of patients with post-traumatic stress disorder (PTSD) according to symptom profile and to examine the association of the A1 allele of the D2 dopamine receptor (DRD2) gene with these clusters.",
"Fifty-seven untreated Caucasian Vietnam veterans with PTSD were administered... | DRD2 variants are associated with severe co-morbid psychopathology in PTSD subjects. | yes |
16,626,516 | Does sulfasalazine prevent apoptosis in spermatogenic cells after experimental testicular torsion/detorsion? | {
"contexts": [
"To determine whether sulfasalazine can prevent apoptosis in spermatogenic cells by preventing the activation of NF-kappaB in spermatogenic epithelium in experimental testicular torsion.",
"Thirty-two adult male Sprague-Dawley rats were subjected to unilateral 720 degree testicular torsion for... | NF-kappaB activation of spermatogenic epithelium is related to apoptosis of spermatogenic cells. Sulfasalazine can prevent apoptosis in spermatogenic cells after the experimental testicular torsion through prevention of NF-kappaB activation. | yes |
16,635,909 | Is functional polymorphism of the NFKB1 gene promoter relevant in predisposition to celiac disease? | {
"contexts": [
"The nuclear factor (NF)-kappaB is one of the pivotal regulators of autoimmunity and inflammation, which has been shown to be activated in the inflamed mucosa of patients with celiac disease (CD). Recently, in the NFKB1 gene promoter region, a common insertion/deletion (-94ins/delATTG) polymorphis... | From these results, it could be suggested that the -94ins/delATTG NFKB1 polymorphism does not play a major role in CD susceptibility. | no |
16,626,493 | Is mutacin H-29B identical to mutacin II ( J-T8 )? | {
"contexts": [
"Streptococcus mutans produces bacteriocins named mutacins. Studies of mutacins have always been hampered by the difficulties in obtaining active liquid preparations of these substances. Some of them were found to be lantibiotics, defined as bacterial ribosomally synthesised lanthionine-containing... | A simple procedure for production and purification of mutacins along with its characterization is presented. Our results show that the amino acid sequence of mutacin H-29B is identical to the already known mutacin II (J-T8) over the first 24 residues. S. mutans strains of widely different origins may thus produce very ... | yes |
16,632,133 | Do small-scale randomized controlled trials need more powerful methods of mediational analysis than the Baron-Kenny method? | {
"contexts": [
"To devise more-effective physical activity interventions, the mediating mechanisms yielding behavioral change need to be identified. The Baron-Kenny method is most commonly used, but has low statistical power and may not identify mechanisms of behavioral change in small-to-medium size studies. Mo... | Methodologically rigorous intervention studies to identify mediators of change in physical activity are costly and labor intensive, and may not be feasible with large samples. The use of statistically powerful tests of mediational effects in small-scale studies can inform the development of more effective interventions... | yes |
16,627,455 | Does post-operative use of heparin increase morbidity of pacemaker implantation? | {
"contexts": [
"The objective of this study is to characterize the incidence of peri-operative severe adverse events (AEs) related to the post-operative use of heparin in patients undergoing pacemaker surgery.",
"We retrospectively compared the outcome of 38 patients with mechanical valves (MVs) and 76 patie... | Post-operative use of heparin increases morbidity of pacemaker implantation. A different approach to management of these patients is possible. | yes |
16,640,791 | Does the genome of Rhizobium leguminosarum have recognizable core and accessory components? | {
"contexts": [
"Rhizobium leguminosarum is an alpha-proteobacterial N2-fixing symbiont of legumes that has been the subject of more than a thousand publications. Genes for the symbiotic interaction with plants are well studied, but the adaptations that allow survival and growth in the soil environment are poorly... | Overall, the genome can be considered to have two main components: a 'core', which is higher in G+C, is mostly chromosomal, is shared with related organisms, and has a consistent phylogeny; and an 'accessory' component, which is sporadic in distribution, lower in G+C, and located on the plasmids and chromosomal islands... | yes |
16,631,582 | Does in vitro FRAP identify the minimal requirements for Mad2 kinetochore dynamics? | {
"contexts": [
"Mad1 and Mad2 are constituents of the spindle-assembly checkpoint, a device coupling the loss of sister-chromatid cohesion at anaphase to the completion of microtubule attachment of the sister chromatids at metaphase. Fluorescence recovery after photobleaching (FRAP) revealed that the interaction... | In vitro FRAP is a widely applicable approach to dissecting the molecular bases of the interaction of a macromolecule with an insoluble cellular scaffold. The combination of in vitro fluorescence recovery after photobleaching with additional fluorescence-based assays in vitro can be used to unveil mechanism, stoichiome... | yes |
16,631,580 | Is hURP a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes? | {
"contexts": [
"Formation of a bipolar mitotic spindle in somatic cells requires the cooperation of two assembly pathways, one based on kinetochore capture by centrosomal microtubules, the other on RanGTP-mediated microtubule organization in the vicinity of chromosomes. How RanGTP regulates kinetochore-microtubu... | Our study identifies HURP as a novel component of the Ran-importin beta-regulated spindle assembly pathway, supporting the conclusion that K-fiber formation and stabilization involves both the centrosome-dependent microtubule search and capture mechanism and the RanGTP pathway. | yes |
16,631,581 | Is hURP part of a Ran-dependent complex involved in spindle formation? | {
"contexts": [
"GTP-loaded Ran induces the assembly of microtubules into aster-like and spindle-like structures in Xenopus egg extract. The microtubule-associated protein (MAP), TPX2, can mediate Ran's role in aster formation, but factors responsible for the transition from aster-like to spindle-like structures ... | HURP is a new and essential component of the mitotic apparatus. HURP acts as part of a multicomponent complex that affects the growth or stability of spindle MTs and is required for spindle MT organization. | yes |
16,643,370 | Does temporary esophageal stenting allow healing of esophageal perforations following atrial fibrillation ablation procedures? | {
"contexts": [
"Left atrial catheter ablation (LACA) has emerged as a successful method to eliminate atrial fibrillation (AF). Recent reports have described atrio-esophageal fistulas, often resulting in death, from this procedure. Temporary esophageal stenting is an established therapy for malignant esophageal d... | Early diagnosis of esophageal perforations following LACA may allow temporary esophageal stenting with successful esophageal healing. Prompt chest CT scans with oral and i.v. contrast should be considered in any patient with sub-sternal chest pain or dysphagia following LACA. | yes |
16,630,361 | Is membrane-associated heparan sulfate required for rAAV-2 infection of human respiratory epithelia? | {
"contexts": [
"Adeno-associated virus type 2 (AAV-2) attachment and internalization is thought to be mediated by host cell membrane-associated heparan sulfate proteoglycans (HSPG). Lack of HSPG on the apical membrane of respiratory epithelial cells has been identified as a reason for inefficient rAAV-2 infectio... | Lack of cell membrane HSPG in pulmonary epithelia and other cell lines results in only moderate decrease in susceptibility to rAAV-2 infection, and this decrease may be less important at high MOIs. Other cell membrane glycosaminoglycans can play a role in permitting attachment and subsequent rAAV-2 internalization. Tar... | no |
16,639,029 | Does fas signaling induce raft coalescence that is blocked by cholesterol depletion in human RPE cells undergoing apoptosis? | {
"contexts": [
"To investigate whether the signaling events occurring in Fas-mediated apoptosis alter raft membrane formation in human RPE cells.",
"Formation of lipid rafts in cultured human retinal pigment epithelial cells (ARPE-19) was studied by confocal microscopy, with fluorescein-labeled cholera toxin... | Human ARPE-19 cells in culture contain membrane rafts with apoptotic signaling effectors uniformly distributed in the native state. The cells stimulated to undergo apoptosis appear to use membrane rafts in the death-signaling process by mobilization of rafts to localized regions of the membrane that are now enriched wi... | yes |
16,639,025 | Is the iron carrier transferrin upregulated in retinas from patients with age-related macular degeneration? | {
"contexts": [
"Iron can cause oxidative stress, and elevated iron levels have been associated with several neurodegenerative diseases including age-related macular degeneration (AMD). Transferrin, an iron transport protein, is expressed at high levels in the retina. The purpose of this study was to assess trans... | These data demonstrate that transferrin expression is increased in the retinas of patients with AMD relative to those of healthy control patients of comparable age. Along with previous studies that have demonstrated elevated iron levels in AMD retinas, early onset drusen formation in a patient with retinal iron overloa... | yes |
16,639,026 | Is endothelial nitric oxide synthase expressed in amacrine cells of developing human retinas? | {
"contexts": [
"To examine the expression and cellular distribution pattern of endothelial nitric oxide synthase (eNOS) in the developing human retina and to compare its expression with that in rats.",
"Expression of eNOS was examined by immunohistochemistry in retinas of humans ranging from 8.5 to 28 weeks ... | The results support that eNOS plays a role, not only in the regulation of vascular function but also in the process of retinal development in humans. | yes |
16,649,381 | Does generation of IL-8 and TNF-alpha in platelet concentrate during storage? | {
"contexts": [
"Platelet transfusion is accompanied by febrile nonhemolytic transfusion reactions. The generation of cytokines (like IL-1 beta, IL-6, IL-8, and TNF-alpha) in platelet concentrates by white cells is suggested to be responsible for febrile nonhemolytic transfusion reactions. The number of white cel... | These data indicate that gamma irradiation can not prevent generation of IL-8 in platelet concentrates during storage, but prestorage leukoreduction of platelet concentrates can prevent accumulation of IL-6, IL-8, and TNF-alpha during storage. | yes |
16,624,683 | Does left ventricular reconstruction bring benefit for patients with ischemic cardiomyopathy? | {
"contexts": [
"Optimal treatment strategies for some patients with ischemic cardiomyopathy can be unclear. We compared the outcome for patients treated with revascularization only or with additional ventricular reconstruction.",
"We compared 74 consecutive patients with an ejection fraction <35% and a left ... | The outcome at midterm of coronary artery surgery alone in patients with a preoperative large left ventricle was inferior compared with the outcome achieved with additional ventricular restoration. | yes |
16,647,928 | Do women seeking treatment for advanced pelvic organ prolapse have decreased body image and quality of life? | {
"contexts": [
"Women who seek treatment for pelvic organ prolapse strive for an improvement in quality of life. Body image has been shown to be an important component of differences in quality of life. To date, there are no data on body image in patients with advanced pelvic organ prolapse. Our objective was to... | Women seeking treatment for advanced pelvic organ prolapse have decreased body image and overall quality of life. Body image may be a key determinant for quality of life in patients with advanced prolapse and may be an important outcome measure for treatment evaluation in clinical trials. | yes |
16,648,657 | Do four peptides decrease human colon adenocarcinoma cell number and DNA synthesis via cyclic GMP? | {
"contexts": [
"Mortality from colon cancer is significant with an expected 30,350 colon cancer deaths in 2005 with current treatment(s). Long-acting natriuretic peptide, vessel dilator, kaliuretic peptide, and atrial natriuretic peptide have significant anticancer effects in breast and pancreatic adenocarcinoma... | Four peptide hormones eliminate up to 97% of colon cancer cells within 24 h with their DNA effects specifically mediated by cyclic GMP. | yes |
16,627,058 | Does motility of the pouch correlate with quality of life after total gastrectomy? | {
"contexts": [
"Jejunal pouch reconstruction is used to provide reservoir function after total gastrectomy, but controversy remains regarding pouch functions and quality of life (QOL). In this study, pouch motility was studied in conjunction with postoperative QOL.",
"Pouch motility of 23 patients with jejun... | An interposed jejunum pouch showed bursts of contractile activity that affected postoperative gastrointestinal function and patient QOL. | yes |
16,650,397 | Do elevated plasma TGF-beta1 levels correlate with decreased survival of metastatic breast cancer patients? | {
"contexts": [
"The role of circulating TGF-beta(1) in prognosis of breast cancer (BC) was investigated with an intention to define TGF-beta(1)-dependent high risk and low risk subsets of patients.",
"Fifty three BC patients of all clinical stages and 37 healthy donors (HD) were analyzed for plasma TGF-beta(... | We have performed a pilot study to determine the relationship between overall survival and TGF-beta(1) concentration in the blood of metastatic breast cancer patients. The survival was significantly reduced in the patients with elevated plasma TGF-beta(1) levels compared to that of the patients with plasma TGF-beta(1) ... | yes |
16,641,048 | Do endothelin-1 serum levels correlate with MCP-1 but not with homocysteine plasma concentration in patients with systemic sclerosis? | {
"contexts": [
"To determine whether homocysteine (Hcy) plasma levels are correlated with molecules indicative of endothelial cell and fibroblast activation, including endothelin-1 (ET-1) and monocyte chemoattractant protein-1 and -3 (MCP-1, MCP-3), in patients with systemic sclerosis (SSc).",
"Eighty-two pa... | In SSc, Hcy plasma concentration does not influence ET-1, MCP-1, or MCP-3 levels. On the contrary, ET-1, a marker of vascular activation, correlates with MCP-1, a chemokine involved in the fibrotic process of SSc. | yes |
16,632,399 | Does [ Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conservative surgery enhance late toxicities ]? | {
"contexts": [
"In 1996, a multicenter randomized study comparing after breast-conservative surgery, sequential vs concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) was initiated (ARCOSEIN study). Seven hundred sixteen patients were included in this trial. After a median follow-up of 6.7 (4.3-9) ... | Following breast conserving surgery, the concurrent use of CT with RT is significantly associated with an increase incidence of grade 2 or greater late side effects. | yes |
16,652,094 | Does everolimus ( RAD ) inhibit in vivo growth of murine squamous cell carcinoma ( SCC VII )? | {
"contexts": [
"Everolimus (RAD) is an mTOR inhibitor closely related to rapamycin. A potent immunosuppressive agent, it has also shown evidence of antineoplastic properties. SCC VII is a spontaneously arising murine squamous cell carcinoma line. This study examines the effect of everolimus on SCC VII proliferat... | Everolimus provides potent tumor inhibition in animals inoculated with SCC VII cells. Inhibition of both local and distant spread of disease is evident. Although most immunosuppressives are known to potentiate neoplastic disease, this study supports the use of everolimus immunosuppression in the face of prior malignanc... | yes |
16,645,453 | Is infarct-remodeled myocardium receptive to protection by isoflurane postconditioning : role of protein kinase B/Akt signaling? | {
"contexts": [
"Postinfarct remodeled myocardium exhibits numerous structural and biochemical alterations. So far, it is unknown whether postconditioning elicited by volatile anesthetics can also provide protection in the remodeled myocardium.",
"Myocardial infarct was induced in male Wistar rats by ligation... | Infarct-remodeled myocardium is receptive to protection by isoflurane postconditioning via protein kinase B/Akt signaling. This is the first time to demonstrate that anesthetic postconditioning retains its marked protection in diseased myocardium. | yes |
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