pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
25,965,447 | Is translation of questionnaires measuring health related quality of life standardized : a literature based research study? | {
"contexts": [
"There is growing awareness of the need to explore patient reported outcomes in clinical trials. In the Scandinavian Surgical Outcomes Research Group we are conducting several clinical trials in cooperation between Danish and Swedish surgical researchers, and we use questionnaires aimed at patient... | This study shows that there seems to be a consensus regarding the translation process (especially for internal validity) although most researchers did not use a translation guide. Moreover, we recommended that clinical researchers should consider three steps covering the process of translation, the qualitative validati... | no |
25,958,483 | Do secondary surgical management of suprachoroidal hemorrhage during pars plana vitrectomy? | {
"contexts": [
"Suprachoroidal hemorrhage (SCH) is one of the most feared and devastating complications of intraocular surgery. Intraoperative SCH is defined as sudden hemorrhagic swelling of the choroid which develops at time of intraocular surgery, and is associated with expulsion of some or all of the intraoc... | Although suprachoroidal hemorrhage is one of most feared and devastating complications ofintraocular surgery, it might have relatively good prognosis with proper preoperative, intraoperative and postoperative management | yes |
25,961,445 | Are small pulmonary artery defects reliable indicators of pulmonary embolism? | {
"contexts": [
"To evaluate the rate of agreement of pulmonary embolism diagnosis in computed tomography (CT) pulmonary angiogram studies and to evaluate the rate of inaccurate interpretations in the community hospital setting.",
"Using the keywords \"pulmonary embolism/embolus/emboli,\" the radiology inform... | There is relatively poor interobserver agreement for subsegmental and/or small pulmonary artery defects, especially in CT pulmonary angiograms degraded by technical artifacts. These factors can lead to an increased frequency of inaccurate interpretation or indeterminate diagnosis of subsegmental and/or small defects. C... | no |
25,976,269 | Is the uniform chest compression depth of 50 mm or greater recommended by current guidelines appropriate for all adults? | {
"contexts": [
"This study was conducted to evaluate the appropriateness of the chest compression (CC) depth recommended in the current guidelines and simulated external CCs, and to characterize the optimal CC depth for an adult by body mass index (BMI).",
"Adult patients who underwent chest computed tomogra... | It is not appropriate that the current CC depth (≥50 mm), expressed only as absolute measurement without a fraction of the depth of the chest, is applied uniformly in all adults. In addition, in terms of safety and efficacy, simulated CC targeting approximately between one-third and one-fourth EAPD CC depth might be ap... | no |
25,985,925 | Does peanut oral immunotherapy transiently expand circulating Ara h 2-specific B cells with a homologous repertoire in unrelated subjects? | {
"contexts": [
"Peanut oral immunotherapy (PNOIT) induces persistent tolerance to peanut in a subset of patients and induces specific antibodies that might play a role in clinical protection. However, the contribution of induced antibody clones to clinical tolerance in PNOIT is unknown.",
"We hypothesized th... | Using a novel affinity selection approach to identify antigen-specific B cells, we demonstrate that the early PNOIT-induced Ara h 2-specific B-cell receptor repertoire is oligoclonal and somatically hypermutated and shares similar clonal groups among unrelated subjects consistent with convergent selection. | yes |
25,965,531 | Do the Influence of an undergraduate scientific initiation programme onn the professional profile of new physicians? | {
"contexts": [
"This paper studies the influence of a Scientific Initiation Programme (SIP) on the professional profile of new doctors from a Brazilian university.",
"Evaluate fifty-two new doctors divided into two groups matched by sex, age and academic performance and differing only in participation in the... | Apparently, taking part in a SIP led to lower income and worse civil servant recruitment exam results. However, this may only reflect a transient phase in a long-term process. New research currently under way will answer this remaining question, now that more time has elapsed since graduation. Rev Port Pneumol 2010; XV... | yes |
25,968,813 | Does quality of the hematopoietic stem cell graft affect the clinical outcome of allogeneic stem cell transplantation? | {
"contexts": [
"In approximately two-thirds of patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) no suitable related donor can be identified but an unrelated HLA-matched donor can be found through international donor registries. HSCT grafts from unrelated donors are commonly collected... | Graft quality affects clinical outcome. Patients receiving grafts with inferior quality had more aGVHD and higher TRM. There is a need for better analyses for assessing graft quality in routine HSCT care; analysis using 7AAD on fresh PBSC grafts is not sufficient. | yes |
25,977,163 | Does myocardial deformation imaging unmask subtle left ventricular systolic dysfunction in asymptomatic and treatment-naïve HIV patients? | {
"contexts": [
"Patients infected by the human immunodeficiency virus (HIV) and receiving highly active antiretroviral therapy have a higher incidence of cardiovascular disease than healthy subjects, but little is known about cardiac function in asymptomatic and treatment-naïve patients. We sought to study cardi... | HIV infection itself is accompanied by subclinical systolic dysfunction, not apparent to standard echocardiography that can be unmasked though using sensitive echocardiographic techniques. | yes |
25,980,632 | Does acute High-Intensity Intermittent Aerobic Exercise reduce Plasma Angiopoietin-Like 2 in Patients With Coronary Artery Disease? | {
"contexts": [
"Circulating levels of angiopoietin-like 2 (ANGPTL2), a proinflammatory and proatherogenic protein, are elevated in patients with coronary artery disease (CAD). We hypothesized that high-intensity intermittent exercise (HIIE), known to be beneficial in patients with CAD, would reduce circulating A... | In patients with CAD, circulating ANGPTL2 levels are acutely reduced after HIIE and transiently increased after MICE. A sustained reduction in circulating ANGPTL2 levels could contribute to the chronic beneficial cardiometabolic effects of HIIE in patients with CAD. | yes |
25,986,683 | Does infrapatellar fat pad preservation reduce wound complications after minimally invasive total knee arthroplasty? | {
"contexts": [
"The aim of this study was to determine whether pain intensity and wound complication rates differ between patients with and without preservation of the infrapatellar fat pad (IPFP) after minimally invasive total knee arthroplasty (TKA). The authors also sought to determine whether IPFP preservati... | Although IPFP preservation delayed operation time, it decreased wound complications after MIS TKA. These findings are important to consider when deciding whether or not to resect the IPFP. Whenever possible, IPFP preservation is probably the preferred technique to reduce wound complications. | yes |
25,967,252 | Are pathologists able to differentiate reliably the lamina propria associated with Barrett 's musculofibrous anomaly from submucosa in oesophageal endoscopic resections? | {
"contexts": [
"Endoscopic resection (ER) is the standard therapy for early oesophageal neoplasia and is used for diagnosis and treatment. Accurate staging is especially important, as further treatment depends on this. Because Barrett's mucosa often develops fibromuscular hyperplasia with a fibrotic lamina propr... | With the application of usually easily recognizable criteria, pathologists are able to differentiate submucosa from lamina propria with musculofibrous anomaly in oesophageal ER specimens with a high degree of reproducibility. | yes |
25,961,186 | Do high Maternal Serum Estradiol Levels Induce Dyslipidemia in Human Newborns via a Hepatic HMGCR Estrogen Response Element? | {
"contexts": [
"While the intrauterine environment is essential for the health of offspring, the impact of high maternal serum estradiol (E2) on lipid metabolism in offspring and the mechanisms are unknown. We found that ovarian stimulation (OS) could result in high E2 levels in women throughout pregnancy. Strik... | OS can induce a high maternal E2 environment, which up-regulates HMGCR expression in fetal hepatocytes via an ERE in the promoter, and induces elevated levels of TC and LDL-C in newborns that may be related to increased risk of metabolic disease in adulthood. | yes |
25,971,703 | Is the cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats related to cell dose and infusion velocity? | {
"contexts": [
"Intra-arterial cell infusion is an efficient delivery route with which to target organs such as the ischemic brain. However, adverse events including microembolisms and decreased cerebral blood flow were recently reported after intra-arterial cell delivery in rodent models, raising safety concern... | Particularly cell dose but also infusion velocity contribute to complications encountered after intra-arterial cell transplantation. This should be considered before planning efficacy studies in rats and, potentially, in patients with stroke. | yes |
25,986,484 | Do aquaporin-4 autoantibodies increase vasogenic edema formation and infarct size in a rat stroke model? | {
"contexts": [
"Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system, which is characterized by autoantibodies directed against the water channel aquaporin-4 (AQP4). As one of the main water regulators in the central nervous system, APQ4 is supposed to be involved in the dynamics of... | These results support the functional impact of NMO-antibodies and also offer an in-vivo-applicable animal model to investigate the properties of AQP4 in ischemic stroke. | yes |
25,960,389 | Is post-translational modification of a chimeric EPO-Fc hormone more important than its molecular size in defining its in vivo hematopoietic activity? | {
"contexts": [
"Recombinant erythropoietin (EPO) has been marketed as biopharmaceutical for anemia and chronic renal failure. Long-acting EPO variants that aimed at achieving less frequent dosing have been generated, either by the addition of glycosylation sites or increasing its molecular weight.",
"The hEP... | The low content of tri- or tetra-antennary sialylated N-glycans linked to the chimeric EPO-Fc hormone, expressed in the goat mammary gland epithelial cells, defined its in vivo hematopoietic activity. | yes |
25,970,828 | Are otic placode cell specification and proliferation regulated by Notch signaling in avian development? | {
"contexts": [
"The entire inner ear including the cochlear-vestibular ganglion arises from a simple epithelium, the otic placode. Precursors for the placode originate from a pool of progenitors located in ectoderm next to the future hindbrain, the pre-otic field, where they are intermingled with future epibranc... | Our results identify a novel function of Notch signaling in cell fate determination in the pre-otic field of avian embryos. | yes |
25,987,769 | Does dihydromyricetin alleviate carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice? | {
"contexts": [
"To assess the effects of dihydromyricetin (DHM) as a hepatoprotective candidate in reducing hepatic injury and accelerating hepatocyte proliferation after carbon tetrachloride (CCl4) treatment.",
"C57 BL/6 mice were used in this study. Mice were orally administered with DHM (150 mg/kg) for 4 ... | These findings demonstrate that DHM alleviates CCl4-induced liver injury, suggesting that DHM is a promising candidate for reversing liver injury and ALF. | yes |
25,962,341 | Are bar shoes and ambient temperature risk factors for exercise-induced pulmonary haemorrhage in Thoroughbred racehorses? | {
"contexts": [
"Ambient temperature has been identified as a risk factor for exercise-induced pulmonary haemorrhage (EIPH) in racing Thoroughbreds. This warranted a more expansive investigation of climatic conditions on the incidence and severity of EIPH. The impact of other variables such as the type of bit use... | Ambient temperature is a risk factor for EIPH in Thoroughbred racehorses, with lower temperatures associated with increased risk. Bar shoes are a novel risk factor for EIPH in this population. | yes |
25,980,529 | Is elevated serum periostin associated with liver stiffness and clinical outcome in biliary atresia? | {
"contexts": [
"To analyze serum periostin and liver stiffness in postoperative biliary atresia (BA).",
"A total of 60 BA patients and 14 controls were enrolled. Serum periostin levels were analyzed by ELISA. Liver stiffness measurement was determined by transient elastography.",
"Biliary atresia patient... | Serum periostin was associated with liver stiffness in BA. Thus, serum periostin has potential as a parameter reflecting the severity in BA. | yes |
25,986,615 | Does lactobacillus reuteri DSM 17938 shorten acute infectious diarrhea in a pediatric outpatient setting? | {
"contexts": [
"Two randomized controlled clinical trials have shown that Lactobacillus (L) reuteri DSM 17938 reduces the duration of diarrhea in children hospitalized due to acute infectious diarrhea. This was the first trial evaluating the efficacy of L. reuteri DSM 17938 in outpatient children with acute infe... | L. reuteri DSM 17938 is effective, safe, and well-tolerated in outpatient children with acute infectious diarrhea. | yes |
25,972,929 | Is bilirubin independently associated with oxidized LDL levels in young obese patients? | {
"contexts": [
"Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored. Our aim is to the association of Ox-LDL with total bilirubin (TB) levels and with variables related with metabolic syndrome and inflammation,... | Lower bilirubin levels may contribute to increased LDL oxidation in obese children and adolescents, predisposing to increased cardiovascular risk. | yes |
25,972,927 | Does dNase I hypersensitivity analysis of the mouse brain and retina identify region-specific regulatory elements? | {
"contexts": [
"The brain, spinal cord, and neural retina comprise the central nervous system (CNS) of vertebrates. Understanding the regulatory mechanisms that underlie the enormous cell-type diversity of the CNS is a significant challenge. Whole-genome mapping of DNase I-hypersensitive sites (DHSs) has been us... | Overall, our results demonstrate the potential of genome-wide DNase I mapping to cis-regulatory questions regarding the regional diversity within the CNS. These data represent an extensive catalogue of potential cis-regulatory elements within the CNS that display region and temporal specificity, as well as a set of DHS... | yes |
25,969,391 | Do stochastic spontaneous calcium release events trigger premature ventricular complexes by overcoming electrotonic load? | {
"contexts": [
"Premature ventricular complexes (PVCs) due to spontaneous calcium (Ca) release (SCR) events at the cell level can precipitate ventricular arrhythmias. However, the mechanistic link between SCRs and PVC formation remains incompletely understood. The aim of this study was to investigate the conditi... | SCR events overcome source-sink mismatch to trigger PVCs at a critical CaSR threshold. Above this threshold, PVCs emerge due to increased probability and reduced variability in timing of SCR events, leading to significant diastolic depolarization. Sites of lower electronic load, such as the PS, are preferential locatio... | yes |
25,987,534 | Do neonatal Pain and Infection Relate to Smaller Cerebellum in Very Preterm Children at School Age? | {
"contexts": [
"To examine whether specific neonatal factors differentially influence cerebellar subregional volumes and to investigate relationships between subregional volumes and outcomes in very preterm children at 7 years of age.",
"Fifty-six children born very preterm (24-32 weeks gestational age) foll... | In very preterm children, exposure to painful procedures, as well as additional neonatal risk factors such as infection, were associated with reduced cerebellar volumes in specific subregions and poorer outcomes at school age. | yes |
25,980,396 | Is constipation associated with diverticular disease - Analysis of 976 patients? | {
"contexts": [
"In the light of controversial data in the literature, the present study was designed to evaluate potential associations between colonic diverticular disease, constipation and quality of life.",
"We prospectively enrolled 976 consecutive patients, who participated in the nationwide colorectal ... | This large population based study revealed no association between colonic diverticular disease and constipation. Notably, the presence of diverticular disease significantly impacts quality of life. | no |
25,963,183 | Is the Artificial Urinary Sphincter Superior to a Secondary Transobturator Male Sling in Cases of a Primary Sling Failure? | {
"contexts": [
"We compared continence outcomes in patients with post-prostatectomy stress urinary incontinence treated with a salvage artificial urinary sphincter vs a secondary transobturator sling.",
"We retrospectively reviewed the records of patients undergoing salvage procedures after sling failure fro... | In this cohort of patients with post-prostatectomy stress urinary incontinence and a failed primary sling those who underwent a secondary sling procedure were up to 6 times more likely to have persistent incontinence vs those who underwent artificial urinary sphincter placement. These data are useful for counseling pat... | yes |
25,963,184 | Does uroepithelial Thickening on Sonography improve Detection of Vesicoureteral Reflux in Children with First Febrile Urinary Tract Infection? | {
"contexts": [
"The 2011 American Academy of Pediatrics clinical practice guideline for childhood febrile urinary tract infection recommends voiding cystourethrography if renal and bladder ultrasound reveals hydronephrosis, scarring or \"other findings\" that suggest high grade vesicoureteral reflux. We sought t... | Uroepithelial thickening is associated with an increased risk of high grade vesicoureteral reflux and is an abnormal finding warranting voiding cystourethrography. Sensitivity of renal and bladder ultrasound as a screening test for high grade vesicoureteral reflux is markedly improved when uroepithelial thickening is c... | yes |
25,987,903 | Does divergence of transcriptional landscape occur early in B cell activation? | {
"contexts": [
"Signaling via B cell receptor (BCR) and Toll-like receptors (TLRs) results in activation of B cells with distinct physiological outcomes, but transcriptional regulatory mechanisms that drive activation and distinguish these pathways remain unknown.",
"Two hours after ligand exposure RNA-seq, ... | Upon examination of genome-wide transcription and regulatory elements, we conclude that the B cell commitment to different activation states occurs much earlier than previously thought and involves a multi-faceted receptor-specific transcriptional landscape. | yes |
25,971,960 | Does receptor Tyrosine Kinase Expression predict Response to Sunitinib in Breast Cancer? | {
"contexts": [
"Preliminary data indicate that tyrosine kinase inhibitors (TKIs) function through rearranged during transfection (RET) in breast cancer. However, TKIs are not specific and can block several receptor tyrosine kinases (RTKs). This study used cell lines and primary breast cancer specimens to determi... | Triple-negative breast cancers overexpress RTKs but have decreased in vitro response to the TKI sunitinib. In addition to RET, TKIs that block EGFR may increase the therapeutic efficacy of TKIs in breast cancer. | yes |
25,958,303 | Does a Novel Swine Model of Spontaneous Hypertension With Sympathetic Hyperactivity respond Well to Renal Denervation? | {
"contexts": [
"The large animal model of arterial hypertension is very valuable to test the antihypertensive drugs and devices. We characterized a novel swine model of spontaneous hypertension and investigated its response to renal denervation (RDN).",
"The blood pressure (BP), levels of plasma catecholamin... | The Guizhou mini-pig is a novel spontaneous hypertensive animal model with sympathetic hyperactivity and responds well to RDN. | yes |
25,969,719 | Are morphological changes of the peripheral nerves evaluated by high-resolution ultrasonography associated with the severity of diabetic neuropathy , but not corneal nerve fiber pathology in patients with type 2 diabetes? | {
"contexts": [
"To evaluate the morphological changes of the median and posterior tibial nerve using high-resolution ultrasonography, and the corneal C fiber pathology by corneal confocal microscopy in type 2 diabetic patients.",
"The cross-sectional area, hypoechoic area and maximum thickness of the nerve f... | The morphological changes in peripheral nerves of type 2 diabetic patients were found before the onset of neuropathy, and were closely correlated with the severity of diabetic neuropathy, but not with corneal C fiber pathology. | yes |
25,966,835 | Does mechanical Tension promote the Osteogenic Differentiation of Rat Tendon-derived Stem Cells Through the Wnt5a/Wnt5b/JNK Signaling Pathway? | {
"contexts": [
"Tendinopathy is a common sports injury that is manifested by the heterotopic ossification of tendon tissue. Tendon stem cells (TSCs) are prone to osteogenic differentiation under excessive tension. The underlying mechanisms remain poorly understood.",
"Uniaxial mechanical tension (UMT) served... | UMT induced the osteogenic differentiation of rTDSCs via the Wnt5a/Wnt5b/JNK signaling pathway. Accordingly, this pathway may influence the heterotopic ossification of tendon tissue subjected to excessive tension. | yes |
25,959,145 | Does epicardial adipose tissue have a unique transcriptome modified in severe coronary artery disease? | {
"contexts": [
"To explore the transcriptome of epicardial adipose tissue (EAT) as compared to subcutaneous adipose tissue (SAT) and its modifications in a small number of patients with coronary artery disease (CAD) versus valvulopathy.",
"SAT and EAT samples were obtained during elective cardiothoracic surg... | The EAT transcriptome is unique when compared to SAT. In the setting of CAD versus valvulopathy, there is possible alteration of the EAT transcriptome with gene suppression. This pilot study explores the transcriptome of EAT in CAD and valvulopathy, providing new insight into its physiologic and pathophysiologic roles. | yes |
25,966,976 | Is cafeteria diet-fed mice a pertinent model of obesity-induced organ damage : a potential role of inflammation? | {
"contexts": [
"This study is aimed at evaluating the effects of a cafeteria diet (obesity) mouse model on early multi-organ functional, structural, endocrine and biochemical alterations.",
"Multi-organ damage is assessed using clinical, biochemical, pathological, and inflammatory parameters in 30 mice fed o... | Functional and structural damage in CAF were higher than HF of similar macronutrient composition. This study provides a novel dietary model in mice that mimics multi-organ physiologic alterations in humans secondary to obesity. | yes |
25,972,260 | Does scatter Photocoagulation Reduce Macular Edema or Treatment Burden in Patients with Retinal Vein Occlusion : The RELATE Trial? | {
"contexts": [
"To determine whether scatter and grid laser photocoagulation (laser) adds benefit to ranibizumab injections in patients with macular edema from retinal vein occlusion (RVO) and to compare 0.5-mg with 2.0-mg ranibizumab.",
"Randomized, double-masked, controlled clinical trial.",
"Thirty-ni... | In patients with macular edema resulting from RVO, there was no short-term clinically significant benefit from monthly injections of 2.0-mg versus 0.5-mg ranibizumab injections and no long-term benefit in BCVA, resolution of edema, or number of ranibizumab injections obtained by addition of laser treatment to ranibizum... | no |
25,973,000 | Does hyperbaric oxygen intervention reduce secondary spinal cord injury in rats via regulation of HMGB1/TLR4/NF-κB signaling pathway? | {
"contexts": [
"To investigate whether hyperbaric oxygen (HBO) intervention affects the expressions of inflammatory cytokines, HMGB1/TLR4/NF-κB, and arrests secondary spinal cord injury (SCI).",
"One hundred and twenty healthy adult SD rats were randomly divided into four groups: sham, sham + HBO, SCI, and S... | Hyperbaric oxygen reduced the expressions of HMGB1, TLR4, and NF-κB and reduced secondary SCI as measured using BBB scores. | yes |
25,962,169 | Do identification of two metallothioneins as novel inhalative coffee allergens cof a 2 and cof a 3? | {
"contexts": [
"Dust of green coffee beans is known to be a relevant cause for occupational allergic disorders in coffee industry workers. Recently, we described the first coffee allergen (Cof a 1) establishing an allergenic potential of green coffee dust.",
"Our aim was to identify allergenic components of ... | In addition to the previously described Cof a 1 we have identified two further coffee proteins to be type I coffee allergens (Cof a 2 and Cof a 3) which may have a relevant potential for the specific diagnosis and/or therapy of coffee allergy. | yes |
25,978,110 | Does pulsatile GnRH be Superior to hCG in Therapeutic Efficacy in Adolescent Boys With Hypogonadotropic Hypogonadodism? | {
"contexts": [
"We investigated the efficacy and safety of two different treatments that have not been evaluated in peripuberty boys with hypogonadotropic hypogonadism (HH).",
"The objective of the study was to assess the effectiveness and safety of GnRH or human chorionic gonadotropin (hCG) treatment in ado... | Boys with HH may be effectively treated with GnRH. We suggested that GnRH exhibits higher efficacy in treating adolescent boys with HH than hCG. | yes |
25,978,682 | Is smoking associated with more abdominal fat in morbidly obese patients? | {
"contexts": [
"While the association between cigarette smoking and abdominal fat has been well studied in normal and overweight patients, data regarding the influence of tobacco use in patients with morbid obesity remain scarce. The aim of this study is to evaluate body fat distribution in morbidly obese smoker... | Positive associations between smoking and BMI, and waist circumference and percentage of body fat, were found among male morbidly obese patients, but not among females. To the best of our knowledge, this study is the first investigation of these aspects in morbidly obese subjects. We speculate that our findings may ind... | yes |
25,958,217 | Are glenoid version and inclination risk factors for anterior shoulder dislocation? | {
"contexts": [
"Although the contribution of the capsuloligamentous structures and dynamic muscle balance to shoulder stability has been well documented, the role of the osseous anatomy of the glenoid has not been thoroughly evaluated. This study investigated glenoid version and inclination in patients with a do... | The results of this study strongly suggest that glenoid version and inclination are significantly increased in patients with established anterior shoulder instability compared with a matched control group. | yes |
25,965,273 | Do adverse childhood experiences influence development of pain during pregnancy? | {
"contexts": [
"To investigate the association between adverse childhood experiences (ACE) and pain with onset during pregnancy.",
"Cross-sectional study.",
"Eighteen antenatal clinics in southern Mid-Sweden.",
"Of 293 women invited to participate, 232 (79%) women agreed to participate in early pregn... | Adverse childhood experiences were associated with higher pain intensities and larger pain distributions in late pregnancy, which are risk factors for transition to chronic pain postpartum. | yes |
25,974,379 | Does tests of the Attachment and Clinical Issues Questionnaire as It apply to Alcohol Dependence? | {
"contexts": [
"Although many major theories tie the addictions to specific pathways and neurochemical systems evolutionarily implicated in food and social behavioral systems, there is a paucity of instruments from the psychological level that can measure these important attachment, social, and emotional counter... | The 2 studies using different populations and definitions of alcohol dependence converged on similar results. The ACIQ was found to be a robust battery for measuring attachment and clinical issues displayed by both patient populations and high school students only predicted to develop alcohol dependence. The results we... | yes |
25,964,036 | Does hyperbaric oxygen therapy increase insulin sensitivity in overweight men with and without type 2 diabetes? | {
"contexts": [
"The onset of insulin resistance is an important metabolic event in the development of type 2 diabetes. For patients with type 2 diabetes, we recently showed that peripheral insulin sensitivity was increased during hyperbaric oxygen treatment (HBOT). This study aims to investigate whether this occ... | Peripheral insulin sensitivity was increased following HBOT in overweight or obese males with and without type 2 diabetes; this increase was maintained for at least 30 minutes post HBOT. Changes in inflammatory cytokines may partly explain this effect. | yes |
25,987,407 | Are increased intraventricular pressures as harmful as the electrophysiological substrate of heart failure in favoring sustained reentry in the swine heart? | {
"contexts": [
"Heart failure (HF) electrophysiological remodeling (HF-ER) often includes the effect of chronically increased intraventricular pressures (IVPs) and promotes ventricular tachycardia/ventricular fibrillation (VT/VF). In addition, acutely increased IVPs have been associated with a higher rate of VT/... | By magnifying DoR, decreasing CV, and shortening APD, increased IVP was as harmful as HF-ER in favoring the substrate for sustained reentry in this model. The AA milieu contributed to a much lesser extent. Thus, a stricter control of IVP might be postulated as a useful add-on antiarrhythmic strategy in HF. | yes |
25,982,698 | Does chronic high fat diet induce cardiac hypertrophy and fibrosis in mice? | {
"contexts": [
"Obesity can cause pathological changes in organs. We determined the effects of chronic high fat diet (HFD) and intermittent fasting, a paradigm providing organ protection, on mouse heart.",
"Seven-week old CD1 male mice were randomly assigned to control, HFD and intermittent fasting groups. C... | These results suggest that chronic HFD induces myocardial hypertrophy and fibrosis, which may be mediated by GSK-3β inhibition. | yes |
25,987,783 | Do inflammation scores predict survival for hepatitis B virus-related hepatocellular carcinoma patients after transarterial chemoembolization? | {
"contexts": [
"To compare the prognostic ability of inflammation scores for patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE).",
"Data of 224 consecutive patients who underwent TACE for unresectable HBV-related HCC from September 2... | The prognostic ability of GPS is superior to other inflammation scores for HCC patients undergoing TACE. Combining GPS and CLIP improved the prognostic power for OS. | yes |
25,988,710 | Does pelitinib ( EKB-569 ) target the up-regulation of ABCB1 and ABCG2 induced by hyperthermia to eradicate lung cancer? | {
"contexts": [
"Pelitinib is a potent irreversible EGFR TK inhibitor currently in clinical trials for the treatment of lung cancer. Hyperthermia has been applied concomitantly with chemotherapy and radiotherapy to enhance treatment outcome. In this study, we investigated the ability of the combination of pelitin... | This study demonstrated a novel approach, exploiting drug resistance, to selectively kill cancer stem-like cells after hyperthermia. | yes |
25,967,040 | Does sE-cadherin serve as a diagnostic and predictive parameter in prostate cancer patients? | {
"contexts": [
"Measurement of prostate-specific antigen (PSA) advanced the diagnostic and prognostic potential for prostate cancer (PCa). However, due to PSA's lack of specificity, novel biomarkers are needed to improve risk assessment and ensure optimal personalized therapy. A set of protein molecules as poten... | sE-cadherin performed most favorably from a large panel of serum proteins in terms of diagnostic and predictive potential in curatively treatable PCa. sE-cadherin merits further investigation as a biomarker for PCa. | yes |
25,960,776 | Are realistic changes in monounsaturated fatty acids and soluble fibers able to improve glucose metabolism? | {
"contexts": [
"Cardioprotective effects of Mediterranean-style diet have been shown. Instead of excluding foods, replacement or addition may facilitate compliance with impact on glucose metabolism of individuals at cardiometabolic risk. This study investigated the effect of changing selected nutrients intake on... | Increases of MUFA and soluble fibers intakes promote benefits on glucose metabolism, independently of adiposity, during a realistic lifestyle intervention in at-risk individuals. Mechanisms mediating these processes may include mainly insulin sensitivity improvement. | yes |
25,960,196 | Do type I interferon and T helper 17 cells co-exist and co-regulate disease pathogenesis in lupus patients? | {
"contexts": [
"T-helper 17 cells (Th17) and type I interferon (IFN-I) play a critical role in the pathogenesis of systemic lupus erythematosus (SLE). Previous studies have suggested that IFN-I suppresses Th17 development under autoimmune settings. Therefore, the main objective of this study was to define the as... | Type I interferon and Th17 pathways co-exist and co-regulate the pathogenic processes in SLE. Additionally, these studies clearly identify IL-6 as a common link between IFN-I and Th17 pathways in SLE pathogenesis. | yes |
25,964,538 | Do reduced UDP-glucose Levels Are Associated with P-glycoprotein Over-expression in L1210 Cells and Limit Glucosylceramide Synthase Activity? | {
"contexts": [
"P-glycoprotein (Pgp) expression in neoplastic cells is known to reduce cell sensitivity to several cytotoxic Pgp substrates. A member of the ABC transporter family, Pgp, represents the most frequently described membrane efflux pump and its expression in neoplastic cells is responsible for multi-d... | These evidence indicates that the down-regulation of UDP-glucose contents in Pgp-positive L1210 cells is responsible for their collateral sensitivity to ceramide-induced apoptosis. | yes |
25,986,582 | Does fecal virome analysis of three carnivores reveal a novel nodavirus and multiple gemycircularviruses? | {
"contexts": [
"More knowledge about viral populations in wild animals is needed in order to better understand and assess the risk of zoonotic diseases. In this study we performed viral metagenomic analysis of fecal samples from three healthy carnivores: a badger (Meles meles), a mongoose (Herpestes ichneumon) a... | Together these results underline that many novel viruses are yet to be discovered and that fecal associated viruses are not always related to disease. Our study expands the knowledge of viral species present in the gut, although the interpretation of the true host species of such novel viruses needs to be reviewed with... | yes |
25,965,529 | Does obesity Influence Outcomes in Hepatocellular Carcinoma Patients following Curative Hepatectomy? | {
"contexts": [
"Whether obesity affects surgical outcomes in patients with hepatocellular carcinoma (HCC) is controversial. Here we retrospectively evaluated the impact of obesity on outcomes in HCC patients after curative hepatectomy.",
"Patients with Child-Pugh A liver function who underwent curative hepat... | Our propensity score-matched analysis strengthens the case that obesity does not adversely affect surgical outcomes of HCC patients undergoing curative hepatectomy. | no |
25,967,585 | Does carotid Arterial Hemodynamic in Ischemic Levkoaraiosis suggest Hypoperfusion Mechanism? | {
"contexts": [
"Leukoaraiosis (ILA) is believed to be ischaemic in origin due to its similar location as that of lacunar infarctions and its association with cerebrovascular risk factors. However, its pathophysiology is not well understood. The ischaemic injuries may be a result of increased pulsatility or cereb... | Lower blood flow and higher resistance of carotid arteries are consistent with the hypo-perfusion theory of ILA. Carotid ultrasound could have a diagnostic and prognostic role in ILA patients. | yes |
25,977,170 | Is expression of metastasis-associated gene-1 associated with bone invasion and tumor stage in human pituitary adenomas? | {
"contexts": [
"Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells.",
"In the present study, we evaluated the expression levels of MTA1 in a cohort of human pit... | MTA1 is associated with the aggressive nature of pituitary tumors and may be a potential therapeutic target in this tumor type. | yes |
25,960,146 | Does lA sprout randomized controlled nutrition and gardening program reduces obesity and metabolic risk in Latino youth? | {
"contexts": [
"To assess the effects of a 12-week gardening, nutrition, and cooking intervention (\"LA Sprouts\") on dietary intake, obesity parameters, and metabolic disease risk among low-income, primarily Hispanic/Latino youth in Los Angeles.",
"The randomized controlled trial involved four elementary sc... | LA Sprouts was effective in reducing obesity and metabolic risk. | yes |
25,986,197 | Is complete seizure freedom possible in patients with MTLE-HS after surgery in spite of extratemporal electro-clinical features? | {
"contexts": [
"The aim was to identify the common typical and atypical ictal semiologic and EEG features of patients with mesial temporal lobe epilepsy and hippocampal sclerosis who became seizure-free postoperatively.",
"The semiologic and EEG findings of 126 ictal video-EEG recordings of 50 patients who r... | This study demonstrated two clusters of the semiologic repertoire, and the most frequent EEG finding was lateralized and localized ictal activity, while other types of EEG patterns were also recorded. Although the presence of atypical findings may suggest a more extended or even extratemporal zone, the seizure-free out... | yes |
25,967,710 | Does network analysis of differentially expressed genes reveal key genes in small cell lung cancer? | {
"contexts": [
"A combination of comparative analysis of gene expression profiles between normal tissue samples and small cell lung cancer (SCLC) samples and network analysis was performed to identify key genes in SCLC.",
"Microarray data set GSE43346 was downloaded from Gene Expression Omnibus (GEO), includ... | A range of DEGs were revealed in SCLC, which could enhance the understandings about the pathogenesis of this disease and provide potential molecular targets for diagnosis as well as treatment. | yes |
25,975,345 | Does small nucleolar RNA 78 promote the tumorigenesis in non-small cell lung cancer? | {
"contexts": [
"Accumulating evidence suggests that dysregulated snoRNA may play a role in the development of malignancy. In the present study, we investigated the role of SNORD78 in the tumorigenesis of non-small cell lung cancer (NSCLC).",
"We determined the expression level of SNORD78 in NSCLC tissues wit... | Our study identified that SNORD78 may be a potential therapeutic target for NSCLC. | yes |
25,958,220 | Does cCAAT/enhancer-binding protein δ ( C/EBPδ ) aggravate inflammation and bacterial dissemination during pneumococcal meningitis? | {
"contexts": [
"The prognosis of bacterial meningitis largely depends on the severity of the inflammatory response. The transcription factor CAAT/enhancer-binding protein δ (C/EBPδ) plays a key role in the regulation of the inflammatory response during bacterial infections. Consequently, we assessed the role of ... | C/EBPδ in the brain drives the inflammatory response and contributes to bacterial dissemination during pneumococcal meningitis. C/EBPδ does, however, not affect clinical parameters of the disease and does not confer a survival benefit. | yes |
25,987,792 | Do ascites and alpha-fetoprotein improve prognostic performance of Barcelona Clinic Liver Cancer staging? | {
"contexts": [
"To assess how ascites and alpha-fetoprotein (AFP) added to the Barcelona Clinic Liver Cancer (BCLC) staging predict hepatocellular carcinoma survival.",
"The presence of underlying cirrhosis, ascites and encephalopathy, Child-Turcotte-Pugh (CTP) score, the number of nodules, and the maximum d... | Adding AFP and ascites to the BCLC staging classification can improve prognosis prediction for early and intermediate stages of hepatocellular carcinoma. | yes |
25,960,234 | Does microRNA-133a improve the cardiac function and fibrosis through inhibiting Akt in heart failure rats? | {
"contexts": [
"MicroRNAs (miRNAs), a group of small non-coding RNAs that fine tune translation of multiple target mRNAs, have been implicated in the development and progression of heart failure.",
"The present study was undertaken to determine the roles of miR-133a on the anatomical, hemodynamic and fibrosi... | These results demonstrated that miR-133a improves the cardiac function and fibrosis through inhibiting Akt in heart failure rats. | yes |
25,960,236 | Does silencing of TRPC1 regulate store-operated calcium entry and proliferation in Huh7 hepatocellular carcinoma cells? | {
"contexts": [
"Previously, we observed reciprocal changes in TRPC1 and TRPC6 expression levels in aging rat aorta and A7r5, rat embryonic vascular smooth muscle cells. Furthermore, downregulation of TRPC1 significantly elevated store-operated Ca(2+) entry suggesting the regulatory role of TRPC1 in A7r5 cells. S... | These results suggest that TRPC1 may take part both in regulation of store-operated Ca(2+) entry and proliferation of hepatocellular carcinoma cells. | yes |
25,972,043 | Does opportunistic mammography screening provide effective detection rates in a limited resource healthcare system? | {
"contexts": [
"Breast cancer is the leading cause of cancer deaths in women world-wide. In low and middle income countries, where there are no population-based mammographic screening programmes, late presentation is common, and because of inadequate access to optimal treatment, survival rates are poor. Mammogra... | From the results, in a setting with resource constraints, targeted screening of high risk individuals will give a higher yield, and if more resources are available, population-based screening of women 50 and above is effective. Opportunistic mammographic screening is feasible and effective in a middle income country wi... | yes |
25,962,494 | Is avoidance of polypharmacy and excessive blood pressure control associated with improved renal function in older patients? | {
"contexts": [
"Elderly patients are particularly susceptible to polypharmacy. The present study evaluated the renal effects of optimizing potentially nephrotoxic medications in an older population.",
"Retrospective study of patients' ≥ 60 years treated between January of 2013 and February of 2015 in a Nephr... | Avoidance of polypharmacy was associated with an improvement in renal function. | yes |
25,981,360 | Is metabolic syndrome in female migraine patients associated with medication overuse headache : a clinic-based study in China? | {
"contexts": [
"Migraine and metabolic syndrome have been reported to coexist to a marked degree, especially in women migraine patients, but the relationship between these two conditions is still unclear. This study was performed to evaluate the association of headache characteristics and its comorbidities with ... | Our study may suggest that chronic migraine is associated with MetS, especially when it is comorbid with analgesic overuse. MOH may be the risk factor for MetS in female migraine patients and associated with abdominal obesity and hypertension. | yes |
25,981,586 | Does single-molecule sequencing reveal the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus? | {
"contexts": [
"Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-associated infection, but there is growing awareness of the emergence of multidrug-resistant lineages in community settings around the world. One such lineage is ST772-MRSA-V, which has disseminated globally and is in... | The genomic characteristics presented here emphasize the contribution of MGEs to the emergence of multidrug-resistant and highly virulent strains of community-associated MRSA. Antibiotic resistance was further augmented by chromosomal mutations and redundancy of resistance genes. The complete genome of DAR4145 provides... | yes |
25,969,382 | Is unreamed Intramedullary Nailing a better alternative than External Fixator for Gustilo grade IIIB Tibial Fractures based on a meta-analysis? | {
"contexts": [
"There remains a controversy between unreamed intramedullary nailing and external fixation to treat Gustilo grade IIIB tibial fractures. To evaluate the comparative effectiveness and safeness of both methods for this type of fracture, we performed this meta-analysis.",
"Relevant original studi... | The existing evidence supports unreamed intramedullary nailing to be a better method for treating Gustilo grade IIIB tibial fractures, and this might aid in the management of this sever injury. | yes |
25,982,697 | Do vaccine-induced Aβ-specific CD8+ T cells do not trigger autoimmune neuroinflammation in a murine model of Alzheimer 's disease? | {
"contexts": [
"Active immunization against Aβ was reported to have a therapeutic effect in murine models of Alzheimer's disease. Clinical Aβ vaccination trial AN1792 was interrupted due to the development in 6 % of the patients of meningoencephalitis likely involving pro-inflammatory CD4(+) T cells. However, th... | Altogether, these results suggest that Aβ-specific CD8(+) T cells are not major contributors to meningoencephalitis in response to Aβ vaccination. | yes |
25,980,696 | Does low expression of B-cell-associated protein 31 in human primary hepatocellular carcinoma correlate with poor prognosis? | {
"contexts": [
"The aim of the present study was to investigate the prognostic value of B-cell associated protein 31 (BAP31) in human primary hepatocellular carcinoma (HCC).",
"BAP31 levels were evaluated by immunohistochemistry on tissue microarrays. The integral optical density, representing the expression... | BAP31 expression is an independent prognostic factor for OS of patients with postoperative HCC, and low expression levels of BAP31 in HCC may indicate poor outcomes of HCC patient after surgical resection. | yes |
25,958,316 | Is body composition associated with multisite lower body musculoskeletal pain in a community-based study? | {
"contexts": [
"Population-based studies suggest that pain in the lower body is common and that pain at multiple sites is more prevalent than single-site pain. Obesity is a risk factor for multisite musculoskeletal pain, but there are limited data on the role of body composition. Therefore, we sought to determin... | Greater fat mass and fat mass index were associated with a greater number of lower body pain sites, with no association observed for fat-free mass. Understanding the mechanism by which increased fat mass is associated with pain may provide important insights into therapeutic strategies for the prevention of pain. | yes |
25,982,462 | Are dietary fatty acid intakes related to the risk of ulcerative colitis : a case-control study? | {
"contexts": [
"The role of dietary fatty acids in ulcerative colitis (UC) pathogenesis has been shown in animal models; however, human studies are rare. We hypothesized that there might be a relationship between dietary fatty acid composition and the risk of developing incident UC.",
"Overall, 62 new cases ... | Our results showed that higher consumptions of total fats, oleic acid, SAFAs, total PUFAs, trans fat, MUFAs, and linoleic acid are significantly associated with increased risk for UC; however, no statistically significant associations were detected between the risk of disease and n-3 PUFAs and cholesterol intake. | yes |
25,962,520 | Does the limited storage capacity of gonadal adipose tissue direct the development of metabolic disorders in male C57Bl/6J mice? | {
"contexts": [
"White adipose tissue (WAT) consists of various depots with different adipocyte functionality and immune cell composition. Knowledge of WAT-depot-specific differences in expandability and immune cell influx during the development of obesity is limited, therefore we aimed to characterise different ... | Marked inter-depot differences exist in WAT immune cell composition and expandability. The limited storage capacity of gWAT seems to direct the development of metabolic disorders in male C57Bl/6J mice. | yes |
25,968,122 | Does carotid Artery Applanation Tonometry Cause Significant Baroreceptor Activation? | {
"contexts": [
"Carotid artery applanation tonometry is widely used in estimating local carotid artery pressure waveforms and carotid-femoral pulse wave velocity. However, the substantial pressure applied locally to the carotid artery with applanation tonometry might well evoke a baroreceptor response, resulting... | We conclude that in our study, carotid artery applanation tonometry as performed by an experienced researcher did not cause clinically significant baroreceptor activation. | no |
25,959,124 | Does resveratrol attenuate microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice? | {
"contexts": [
"Obesity, a sirtuin-1 (SIRT-1) -deficient state, increases morbidity and resource utilization in critically ill patients. SIRT-1 deficiency increases microvascular inflammation and mortality in early sepsis. The objective of the study was to study the effect of resveratrol (RSV), a SIRT-1 activato... | RSV increases SIRT-1 expression in ob/ob septic mice to reduce microvascular inflammation and improves survival. | yes |
25,987,977 | Is muscular dystrophy in the mdx mouse a severe myopathy compounded by hypotrophy , hypertrophy and hyperplasia? | {
"contexts": [
"Preclinical testing of potential therapies for Duchenne muscular dystrophy (DMD) is conducted predominantly of the mdx mouse. But lack of a detailed quantitative description of the pathology of this animal limits our ability to evaluate the effectiveness of putative therapies or their relevance t... | The best-known consequence of lack of dystrophin that is common to DMD and the mdx mouse is the conspicuous necrosis and regeneration of muscle fibres. We present protocols for measuring this in terms both of loss of muscle nuclei previously labelled with BrdU and of the intensity of myonuclear labelling with BrdU admi... | yes |
25,964,525 | Do exosome-like Extracellular Vesicles from MYCN-amplified Neuroblastoma Cells Contain Oncogenic miRNAs? | {
"contexts": [
"In recent years, evidence has accumulated indicating that both normal and cancer cells communicate via the release and delivery of macromolecules packed into extracellular membrane vesicles.",
"We isolated nano-sized extracellular vesicles from MYCN-amplified neuroblastoma cell lines using ul... | MYCN-amplified neuroblastoma cell lines secrete exosome-like particles containing oncogenic miRNAs. This work showed for the first time that neuroblastoma cells secrete exosome-like particles containing miRNAs with potential roles in cancer progression. These findings indicate a new way for MYCN-amplified neuroblastoma... | yes |
25,975,207 | Are femoral diameter and stem type independent risk factors for ARMD in the large-headed ASR THR group? | {
"contexts": [
"Adverse soft-tissue reaction to metal debris (ARMD) continues to be major source of concern in metal-on-metal (MoM) hip replacements. In our earlier study we were able to establish several risk factors for ARMD in patients who had received a small-diameter (<50 mm) Articular Surface Replacement (... | Stem type and increasing femoral size as independent risk factors for ARMD in the cohort of ASR XL THR patients, support the importance of taper failure in the development of ARMD. The present results suggest that the degree of taper failure may be variable and dependent on the taper design. | yes |
25,965,642 | Do different types of antagonists modify the outcome of complete denture renewal? | {
"contexts": [
"The effect of renewing removable dentures on masticatory function was evaluated according to the occlusion offered by different types of mandibular arches.",
"Twenty-eight patients with complete maxillary dentures were subdivided into three groups in terms of mandibular dentition type: dentat... | Denture renewal improves masticatory function. The complete denture group benefited least from renewal; the dentate group benefited most. This study confirmed the usefulness of denture renewal for improving functions and oral health- related quality of life. | yes |
25,964,315 | Does streptococcus pneumoniae trigger progression of pulmonary fibrosis through pneumolysin? | {
"contexts": [
"Respiratory tract infections are common in patients suffering from pulmonary fibrosis. The interplay between bacterial infection and fibrosis is characterised poorly.",
"To assess the effect of Gram-positive bacterial infection on fibrosis exacerbation in mice.",
"Fibrosis progression in ... | Our data unravel a novel mechanism by which infection with Spn through Ply release induces progression of established lung fibrosis, which can be attenuated by protein-based vaccination of mice. | yes |
25,986,742 | Does parkinson bradykinesia correlate with EEG background frequency and perceptual forward projection? | {
"contexts": [
"To deal with processing-time in the nervous system, visuomotor control requires anticipation. An index for such anticipation is provided by the 'flash-lag illusion' in which moving objects are perceived ahead of static objects while actually being in the same place. We investigated the neurophysi... | The decreased flash-lag illusion and lower electroencephalography background frequency in more bradykinetic PD patients provides support for disturbed visuomotor anticipations, putatively caused by reduced, sub-cortically mediated, network efficiency. This suggests a link between anticipation in early-stage visual moti... | yes |
25,960,992 | Do evaluation of diagnostic biomarkers for acute kidney injury in major burn patients? | {
"contexts": [
"Acute kidney injury (AKI) in major burn patients is a common complication with high morbidity and mortality. The mainstream treatment is early diagnosis and rapid termination and prevention of the underlying insult. Therefore, it's essential to identify early biomarkers predicting AKI.",
"A t... | LD, lactic acid and serum creatinine were acceptable as diagnostic biomarkers of AKI and LD, serum creatinine, AST, and serum myoglobin were reasonable as diagnostic biomarkers of early AKI. However, cystatin C was an unfavorable biomarker in major burn patients. | yes |
25,978,106 | Does the Use of 123I in Diagnostic Radioactive Iodine scan in Children with Differentiated Thyroid Carcinoma? | {
"contexts": [
"Adult studies have shown that iodine-123 ((123)I) is as effective as (131)I in detecting metastatic disease in patients with differentiated thyroid carcinoma. However, the type and administered activity of radioiodine used for diagnostic imaging of metastatic thyroid cancer has not been well stud... | (123)I is effective for use in diagnostic radioactive iodine scans in children with differentiated thyroid cancer. The primary advantages of using (123)I include decreased radiation exposure and avoidance of stunning. However, in children there is a possibility of missed detection of metastatic pulmonary disease. | yes |
25,971,887 | Does oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorate cauda equina compression injury in rats? | {
"contexts": [
"Phospholipase A2 (PLA2)-derived proinflammatory lipid mediators such as prostaglandin E2 (PGE2), leukotrienes B4 (LTB4), lysophosphatidylcholine (LPC), and free fatty acids (FFA) are implicated in spinal cord injury (SCI) pathologies. Reducing the levels of these injurious bioactive lipid mediato... | The data indicate that cPLA2 activity plays a significant role in tissue injury and pain after LSS. Reducing the levels of proinflammatory and tissue damaging eicosanoids and the deleterious lipid mediator LPC shows therapeutic potential. ATK inhibits cPLA2 activity, thereby decreasing the levels of injurious lipid med... | yes |
25,973,387 | Is nuclear Factor-Y an adipogenic factor that regulates leptin gene expression? | {
"contexts": [
"Leptin gene expression is highly correlated with cellular lipid content in adipocytes but the transcriptional mechanisms controlling leptin expression in vivo are poorly understood. In this report, we set out to identify cis- and trans-regulatory elements controlling leptin expression.",
"Lep... | These studies advance our understanding of leptin gene expression and show that NF-Y controls the expression of leptin and other adipocyte genes and identifies a new form of lipodystrophy. | yes |
25,960,412 | Are genetic variations in genes involved in testosterone metabolism associated with prostate cancer progression : A Spanish multicenter study? | {
"contexts": [
"Prostate cancer (PCa) is an androgen-dependent disease. Nonetheless, the role of single nucleotide polymorphisms (SNPs) in genes encoding androgen metabolism remains an unexplored area.",
"To investigate the role of germline variations in cytochrome P450 17A1 (CYP17A1) and steroid-5α-reductas... | SNPs in SRD5A1 seem to affect the clinical characteristics of Spanish patients with PCa. | yes |
25,968,613 | Does comprehensive Analysis of Large Sets of Age-Related Physiological Indicators reveal Rapid Aging around the Age of 55 Years? | {
"contexts": [
"While many studies show a correlation between chronological age and physiological indicators, the nature of this correlation is not fully understood.",
"To perform a comprehensive analysis of the correlation between chronological age and age-related physiological indicators.",
"Physiologi... | These findings provide evidence that the progression of physiological age is not linear with that of chronological age, and that periods of mild change in physiological age are separated by periods of more rapid aging. | yes |
25,960,391 | Does a novel anti-microtubule agent with carbazole and benzohydrazide structures suppress tumor cell growth in vivo? | {
"contexts": [
"The mitotic spindles are among the most successful targets of anti-cancer chemotherapy, and they still hold promise as targets for novel drugs. The anti-mitotic drugs in current clinical use, including taxanes, epothilones, vinca alkaloids, and halichondrins, are all microtubule-targeting agents.... | Taken together, these findings suggest that HND-007 is a promising lead compound for development of novel anti-mitotic, anti-microtubule chemotherapeutic agents. | yes |
25,985,773 | Is salt tolerance evolutionarily labile in a diverse set of angiosperm families? | {
"contexts": [
"Salt tolerance in plants is rare, yet it is found across a diverse set of taxonomic groups. This suggests that, although salt tolerance often involves a set of complex traits, it has evolved many times independently in different angiosperm lineages. However, the pattern of evolution of salt toler... | Our results suggest that the pattern of many independent gains of salt tolerance near the tips of the phylogeny is found in many angiosperm families. This suggests that the pattern reported in the grasses of high evolutionary lability may be a common feature of salt tolerance evolution in angiosperms. | yes |
25,963,357 | Does serum hepcidin predict uremic accelerated atherosclerosis in chronic hemodialysis patients with diabetic nephropathy? | {
"contexts": [
"Hepcidin, as a regulator of body iron stores, has been recently discovered to play a critical role in the pathogenesis of anemia of chronic disease. Atherosclerotic cardiovascular disease is the most common complication and the leading cause of death in chronic hemodialysis (CHD) patients. In the... | These findings suggest possible linkage between iron metabolism and hepcidin modulation abnormalities that may contribute to the development of UAAS in CHD/DN patients. | yes |
25,973,320 | Are membranous expressions of Lewis y and CAM-DR-related markers independent factors of chemotherapy resistance and poor prognosis in epithelial ovarian cancer? | {
"contexts": [
"Chemotherapy resistance is a common problem faced by patients diagnosed with epithelial ovarian cancer (EOC). Currently there are no specific or sensitive clinical biomarkers that maybe implemented to identify chemotherapy resistance and give insight to prognosis. The aim of this study is to inve... | Membranous expression of Lewis y and CAM-DR-related markers including CD44, CD147, HE4, integrin α5, β1, αv and β3 are associated with the development of chemotherapy resistance. High expression of Lewis y antigen and CAM-DR-related markers including CD44, CD147, HE4, integrin α5 and β1 are independent markers for PFS ... | yes |
25,960,701 | Does aging affect morphology but not stimulated secretion of saliva in rats? | {
"contexts": [
"The role of aging on the salivary gland function still remains controversial and inconclusive. This study was undertaken to determine the effects of aging on the morphology and secretion of salivary glands using male Wistar rats.",
"There were three age groups; group A (3 months old; n = 8), ... | These findings showed that varying changes were observed in the morphology of salivary glands of aging rats without impaired function. | yes |
25,986,529 | Does patatin-Like Phospholipase Domain-Containing 3 I148M Variant be Associated with Liver Steatosis and Fat Distribution in Chronic Hepatitis B? | {
"contexts": [
"The patatin-like phospholipase domain-containing 3 gene (PNPLA3) has been associated with liver steatosis and disease progression in nonalcoholic steatohepatitis and chronic hepatitis C.",
"The aim of the present study was to evaluate the influence of the PNPLA3 I148M polymorphisms on the cli... | In our CHB patients, the PNPLA3 polymorphisms influenced the development of liver steatosis, but not fibrosis status. The association of PNPLA3 p.I148M with liver steatosis increased with the greater amount of abdominal fat, irrespective of BMI. | yes |
25,979,041 | Does dynamic contrast-enhanced MR microscopy identify regions of therapeutic response in a preclinical model of colorectal adenocarcinoma? | {
"contexts": [
"A typical dynamic contrast-enhanced (DCE)-MRI study often compares the derived pharmacokinetic parameters on manually selected tumor regions or over the entire tumor volume. These measurements include domains where the interpretation of the biomarkers may be unclear (such as in necrotic areas). H... | Two regions with distinct kinetic parameters were identified based on the histogram of TTP. The effect of bevacizumab, as measured by a decrease in K(trans), was confined to one of these regions. High spatiotemporal resolution MR studies may contribute unique insights into the response of the tumor microenvironment to ... | yes |
25,974,422 | Are c-reactive protein levels associated with cerebral small vessel-related lesions? | {
"contexts": [
"Inflammation has received increasing attention as a cause of stroke. Although several lines of evidence suggest that inflammatory processes have a role in arteriosclerotic vascular events, their involvement remains to be determined. The purpose of this study was to examine the associations betwee... | Higher levels of hs-CRP were associated with lacunar infarcts. Thus, inflammatory processes may be involved in the pathogenesis of small-vessel disease. | yes |
25,968,901 | Is hyperuricaemia associated with renal damage independently of hypertension and intrarenal renin-angiotensin system activation , as well as their circadian rhythms? | {
"contexts": [
"Both hyperuricaemia and activation of the intrarenal renin-angiotensin system (RAS) play an important role in the development of hypertension and renal damage. However, it has not been clear whether hyperuricaemia is associated with renal damage due to hypertension or intrarenal RAS activation, a... | These data suggest that hyperuricaemia is associated with renal damage, independently of hypertension and intrarenal RAS activation, as well as their circadian rhythms. | yes |
25,970,666 | Does light Physical Activity be Associated with Quality of Life after Colorectal Cancer? | {
"contexts": [
"Emerging evidence suggests that light physical activity (LPA), besides moderate-to-vigorous physical activity (MVPA), may beneficially influence physical functioning of colorectal cancer survivors, but its relation with other health-related outcomes is unknown. We applied a biopsychosocial approa... | Self-reported LPA, besides MVPA, was beneficially associated with multiple HRQoL outcomes in colorectal cancer survivors, especially in women and survivors with multiple comorbidities. Prospective studies are warranted to establish whether LPA is a suitable target for personalized lifestyle interventions to improve the... | yes |
25,971,532 | Does decline in CA19-9 during chemotherapy predict survival in four independent cohorts of patients with inoperable bile duct cancer? | {
"contexts": [
"Carbohydrate associated antigen (CA19-9) has been approved by the FDA as a biomarker for monitoring treatment effect in pancreatic cancer. However, the value of serum CA19-9 as a biomarker of response to chemotherapy in bile duct cancer is unclear. The aim of this study was to determine if a decl... | CA19-9 response is a robust predictor of survival in patients with inoperable bile duct cancer in four independent data sets. | yes |
25,969,530 | Do variants in the Mannose-binding Lectin Gene MBL2 Associate With Sepsis Susceptibility or Survival in a Large European Cohort? | {
"contexts": [
"Sepsis is an increasingly common condition, which continues to be associated with unacceptably high mortality. A large number of association studies have investigated susceptibility to, or mortality from, sepsis for variants in the functionally important immune-related gene MBL2. These studies ha... | In this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified. | no |
25,963,437 | Do coliform bacteria isolated from recreational lakes carry class 1 and class 2 integrons and virulence-associated genes? | {
"contexts": [
"To characterize the integron-harbouring Gram-negative bacteria in recreational lakes, with focus on the genetic content of integrons, antimicrobial resistance profiles and virulence-associated genes.",
"The presence and structure of integrons in coliform bacteria isolated from the water of fo... | Integron-bearing multidrug resistant coliform bacteria carrying virulence genes are present in waters of recreational lakes. | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.