pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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25,988,518 | Is baseline Perineural Invasion Associated with Shorter Time to Progression in Men with Prostate Cancer Undergoing Active Surveillance : Results from the REDEEM Study? | {
"contexts": [
"We evaluated the association of perineural invasion with disease progression in men with prostate cancer on active surveillance.",
"We retrospectively analyzed the records of 302 men on active surveillance for low risk prostate cancer (T1c-T2a), Gleason 6 or less, 3 or fewer positive cores, 5... | Among patients with prostate cancer on active surveillance perineural invasion was associated with an increased risk of clinical progression. The 2-year risk of clinical progression with perineural invasion was 73%. If these results are confirmed, patients with perineural invasion may not be good active surveillance ca... | yes |
25,960,639 | Do wnt blockers inhibit the proliferation of lung cancer stem cells? | {
"contexts": [
"Previous study has confirmed that the occurrence of Wnt pathway activation is associated with risk of non-small-cell lung cancer recurrence. However, whether the pharmacologic blocking of the Wnt signaling pathway could provide therapeutic possibility remains unknown. The aim of the present study... | Wnt signaling inhibitor PP can inhibit proliferation of LCSCs, and the Wnt signaling pathway could be considered a promising therapeutic or interventional target in lung adenocarcinoma. | yes |
25,985,904 | Does carcinogenic Liver Fluke secrete Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype? | {
"contexts": [
"Throughout Asia, there is an unprecedented link between cholangiocarcinoma and infection with the liver fluke Opisthorchis viverrini. Multiple processes, including chronic inflammation and secretion of parasite proteins into the biliary epithelium, drive infection toward cancer. Until now, the me... | This is the first time that EVs from a multicellular pathogen have been identified in host tissues. Our findings imply a role for O. viverrini EVs in pathogenesis and highlight an approach to vaccine development for this infectious cancer. | yes |
25,978,337 | Does dichotomous `` Good Outcome '' indicate Mobility More Than Cognitive or Social Quality of Life? | {
"contexts": [
"Worthwhile interventions for intracerebral hemorrhage or subarachnoid hemorrhage generally hinge on whether they improve the odds of good outcome. Although good outcome is correlated with mobility, correlations with other domains of health-related quality of life, such as cognitive function and s... | Health-related quality of life assessments reliably distinguished between good and poor outcomes as determined by the modified Rankin Scale. Good outcome indicated health-related quality of life about 1.5 SD below the U.S. population mean. Associations were weaker for cognitive function and social function than mobilit... | yes |
25,961,820 | Does loss of Bace1 in mice alter the severity of caerulein induced pancreatitis? | {
"contexts": [
"Beta-site alpha-amyloid protein cleaving enzyme1 (BACE1) plays a key role in the pathogenesis of Alzheimer's disease. Additional to its moderate expression in the brain, high levels of BACE1 mRNA were found in the pancreas. Murine Bace1 has been immunohistochemicaly detected at the apical pole of... | We discuss the results in the context of the applied caerulein induced edematous pancreatitis model and possible compensatory mechanisms via Bace2 that might be responsible for the observed results. | no |
25,967,721 | Is non-extracorporeal circulation for coronary artery bypass graft surgery more beneficial than extracorporeal circulation? | {
"contexts": [
"The objective of this study was to compare coronary artery bypass graft (CABG) surgery with non-extracorporeal vs. extracorporeal circulation. The study outcomes included operative time, number of graft vessels, pulmonary infection rates, and systemic inflammatory markers.",
"96 patients rece... | Extracorporeal circulation prolongs operation and can aggravate systemic inflammatory response. Therefore, CABG with non-extracorporeal circulation offers more beneficial outcomes. | yes |
25,967,572 | Does white Matter Damage relate to Oxygen Saturation in Children With Sickle Cell Anemia Without Silent Cerebral Infarcts? | {
"contexts": [
"Sickle cell anemia is associated with compromised oxygen-carrying capability of hemoglobin and a high incidence of overt and silent stroke. However, in children with no evidence of cerebral infarction, there are changes in brain morphometry relative to healthy controls, which may be related to ch... | These data show widespread white matter abnormalities in a sample of asymptomatic children with sickle cell anemia, and provides for the first time direct evidence of a relationship between brain microstructure and markers of disease severity (eg, peripheral oxygen saturation and steady-state hemoglobin). This study su... | yes |
25,961,292 | Does neutrophil-to-Lymphocyte Ratio be Associated with Impaired Interferon-Gamma Release to Phytohemagglutinin? | {
"contexts": [
"The neutrophil-to-lymphocyte ratio (NLR) has been shown to predict adverse outcomes in several pathologic conditions. The majority of indeterminate interferon (IFN)-γ release assays were due to inadequate IFN-γ response to the phytohemagglutinin. We sought to study the value of NLR to predict an ... | We showed that the NLR is an independent predictor of indeterminate QFT-GIT result. Low frequency of indeterminate results in group with normal NLR may imply the importance of a balance between two cellular compartments in physiological and pathological conditions. | yes |
25,981,118 | Does intravitreal inhibition of complement C5a reduce choroidal neovascularization in mice? | {
"contexts": [
"To investigate the influence of complement component C5a inhibition on laser-induced choroidal neovascularization (CNV) in mice using a C5a specific L-aptamer.",
"In C57BL/6 J mice CNV was induced by argon-laser, C5a-inhibitor (NOX-D20) was intravitreally injected in three concentrations: 0.3... | Our findings demonstrate that the targeted inhibition of complement component C5a reduces vascular leakage and neovascular area in laser-induced CNV in mice. NOX-D20 was proven to be an effective and safe agent that might be considered as a therapeutic candidate for CNV treatment. The deficiency of activated immune cel... | yes |
25,962,635 | Is brain tumor a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition? | {
"contexts": [
"Brain tumor (BRAT) is a Drosophila member of the TRIM-NHL protein family. This family is conserved among metazoans and its members function as post-transcriptional regulators. BRAT was thought to be recruited to mRNAs indirectly through interaction with the RNA-binding protein Pumilio (PUM). Howe... | Our results represent the first genome-wide analysis of the mRNAs associated with a TRIM-NHL protein and the first identification of an RNA motif bound by this protein family. BRAT is a prominent post-transcriptional regulator in the early embryo through mechanisms that are largely independent of PUM. | yes |
25,962,534 | Does improvement of Bovine Nucleus Pulposus Cells Isolation lead to Identification of Three Phenotypically Distinct Cell Subpopulations? | {
"contexts": [
"Strategies to promote intervertebral disc (IVD) regeneration have been hindered by the lack of knowledge of IVD fundamental cellular/molecular components. One of the key points to be addressed is the characterization of nucleus pulposus (NP) cell population(s). This study establishes an improved ... | This study demonstrated that collagenase-type-XI is an efficient enzyme that is used for digesting bNP. And most importantly, three phenotypically distinct subpopulations of cells where identified within the bNP. Such knowledge is key for a better understanding of NP cell biology and its potential endogenous regenerati... | yes |
25,962,530 | Does carotid intima-media thickness measurement promise to improve cardiovascular risk evaluation in head and neck cancer patients? | {
"contexts": [
"Radiation-treated head and neck cancer (HNC) patients are at high risk for developing radiation vasculopathy, as evidenced by an increased stroke risk. The benefits of screening and assessing the cardiovascular (CV) risk of HNC patients using carotid intima-media thickness (CIMT) ultrasound are n... | Carotid IMT identified a much greater percentage of radiation-treated HNC patients at high CV risk compared with standard CV-risk calculators. By more accurately identifying the patients at high risk, this may lead to more effective prevention, and therefore a reduction in CV events. | yes |
25,976,242 | Does gCKR polymorphism influence liver fat content in patients with type 2 diabetes? | {
"contexts": [
"It has recently been shown that an allele in the glucokinase regulatory protein (GCKR) gene was associated with increased liver fat content in obese children. In this study, we set out to determine whether GCKR rs1260326 polymorphism was associated with liver fat content in patients with type 2 d... | This study shows that in patients with type 2 diabetes who were not selected for liver abnormalities, liver fat content was related to GCKR rs1260326 polymorphism independent of BMI, triglyceride levels, and age. | yes |
25,976,240 | Are most partial domains in proteins alignment and annotation artifacts? | {
"contexts": [
"Protein domains are commonly used to assess the functional roles and evolutionary relationships of proteins and protein families. Here, we use the Pfam protein family database to examine a set of candidate partial domains. Pfam protein domains are often thought of as evolutionarily indivisible, s... | Partial domains are largely the result of alignment and annotation artifacts and should be viewed with caution. The presence of partial domain annotations in proteins should raise the concern that the prediction of the protein's gene may be incomplete. In general, protein domains can be considered the structural buildi... | yes |
25,961,461 | Does anacetrapib lower LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects? | {
"contexts": [
"Individuals treated with the cholesteryl ester transfer protein (CETP) inhibitor anacetrapib exhibit a reduction in both LDL cholesterol and apolipoprotein B (ApoB) in response to monotherapy or combination therapy with a statin. It is not clear how anacetrapib exerts these effects; therefore, th... | These data indicate that anacetrapib, given alone or in combination with a statin, reduces LDL-ApoB-100 levels by increasing the rate of ApoB-100 fractional clearance. | yes |
25,971,721 | Is adequate enteral protein intake inversely associated with 60-d mortality in critically ill children : a multicenter , prospective , cohort study? | {
"contexts": [
"The impact of protein intake on outcomes in pediatric critical illness is unclear.",
"We examined the association between protein intake and 60-d mortality in mechanically ventilated children.",
"In a prospective, multicenter, cohort study that included 59 pediatric intensive care units (... | Delivery of >60% of the prescribed protein intake is associated with lower odds of mortality in mechanically ventilated children. Optimal prescription and modifiable practices at the bedside might enhance enteral protein delivery in the PICU with a potential for improved outcomes. This trial was registered at clinicalt... | yes |
25,959,500 | Does systemic Inflammatory Response Syndrome predict Severity of Stroke and Outcome? | {
"contexts": [
"This study was undertaken to evaluate the frequency of systemic inflammatory response syndrome (SIRS) at admission and its correlation with clinical and radiological severity of stroke and outcome.",
"Two hundred consecutive stroke patients within 48 hours of ictus were prospectively included... | SIRS at presentation is a useful marker for clinicoradiological severity of stroke but not an independent marker of death and disability. | yes |
25,974,723 | Do lipid-based nutrient supplements affect efavirenz but lower plasma nevirapine concentrations in Ethiopian adult HIV patients? | {
"contexts": [
"Lipid-based nutrient supplements (LNSs) are increasingly used in HIV programmes in resource-limited settings. However, the possible effects of LNSs on the plasma concentrations of antiretroviral drugs have not been assessed. Here, we aimed to assess the effects of LNSs on plasma efavirenz and nev... | Intake of an LNS was associated with lower plasma nevirapine trough concentrations, indicating possible drug-LNS interactions. The clinical relevance of such reductions in nevirapine exposure is not clear. Plasma efavirenz concentration was not affected by the LNS. | no |
25,962,362 | Are paraoxonase ( PON1 ) polymorphisms Q192R and L55M associated with human longevity : A meta-analysis? | {
"contexts": [
"Genetic mutations in the paraoxonase 1 (PON1) encoding gene have been considered to affect mortality and of these the functional promoter region polymorphisms Q192R and L55M are among the most widely studied.",
"The aim of this study was to determine whether the Q192R and L55M polymorphisms o... | No evidence that the Q192R and L55M polymorphisms of PON1 impacted on the probability of reaching extreme ages was found although this cannot be completely ruled out; however, the possibility of population-specific effects due to the influence of and interaction between different genes or environmental factors could no... | no |
25,963,716 | Does deficiency of MMP17/MT4-MMP proteolytic activity predispose to aortic aneurysm in mice? | {
"contexts": [
"Aortic dissection or rupture resulting from aneurysm causes 1% to 2% of deaths in developed countries. These disorders are associated with mutations in genes that affect vascular smooth muscle cell differentiation and contractility or extracellular matrix composition and assembly. However, as man... | Mmp17 proteolytic activity regulates vascular smooth muscle cell phenotype in the arterial vessel wall, and its absence predisposes to thoracic aortic aneurysm in mice. The rescue of part of the vessel-wall phenotype by a lentiviral strategy opens avenues for therapeutic intervention in these life-threatening disorders... | yes |
25,960,020 | Does heparin enhance uptake of platelet factor 4/heparin complexes by monocytes and macrophages? | {
"contexts": [
"Heparin-induced thrombocytopenia (HIT) is an iatrogenic complication of heparin therapy caused by antibodies to a self-antigen, platelet factor (4) and heparin. The reasons why antibodies form to PF4/heparin, but not to PF4 bound to other cellular glycosaminoglycans are poorly understood.",
"... | Taken together, these studies establish a distinct role for heparin in enhancing antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes. | yes |
25,982,007 | Does clinician-delivered contingency management increase engagement and attendance in drug and alcohol treatment? | {
"contexts": [
"This study examined the impact of a low-cost contingency management (CM) delivered by program clinicians on treatment attendance and utilization for patients enrolled in outpatient psychosocial substance abuse treatment.",
"The study used a pre-posttest design to compare substance abuse patie... | Findings support the feasibility and effectiveness of a CM intervention delivered by clinicians for increasing treatment attendance and utilization in a community substance abuse program. | yes |
25,987,024 | Does high Expression of Matrix Metalloproteinase-11 indicate Poor Prognosis in Human Cholangiocarcinoma? | {
"contexts": [
"Cholangiocarcinoma (CHCA) is serious public health problem in Thailand, especially in the northeastern and northern regions. CHCA is known as one of the most aggressive malignant tumors associated with local invasion and a high rate of metastasis. A crucial step in the invasion process is the pro... | The positive MMP-11 expression indicates poor prognosis in CHCA specimens. | yes |
25,987,023 | Do comparative proteomics and global genome-wide expression data implicate role of ARMC8 in lung cancer? | {
"contexts": [
"Cancer loci comprise heterogeneous cell populations with diverse cellular secretions. Therefore, disseminating cancer-specific or cancer-associated protein antigens from tissue lysates could only be marginally correct, if otherwise not validated against precise standards.",
"In this study, 2D... | The findings in this report are suggestive of a regulatory role of ARMC8 in control of proliferation and differentiation in lung adenocarcinomas. | yes |
25,977,565 | Does reduction of Mitochondria-Endoplasmic Reticulum Interactions by Acetylcholine protect Human Umbilical Vein Endothelial Cells From Hypoxia/Reoxygenation Injury? | {
"contexts": [
"We explored the role of endoplasmic reticulum (ER)-mitochondria Ca(2+) cross talk involving voltage-dependent anion channel-1 (VDAC1)/glucose-regulated protein 75/inositol 1,4,5-trisphosphate receptor 1 complex and mitofusin 2 in endothelial cells during hypoxia/reoxygenation (H/R), and investiga... | Our data suggest that ER-mitochondria interplay plays an important role in reperfusion injury in the endothelium and may be a novel molecular target for endothelial protection. Acetylcholine attenuates both intracellular and mitochondrial Ca(2+) overload and protects endothelial cells from H/R injury, presumably by dis... | yes |
25,986,200 | Does sleep influence the intracerebral EEG pattern of focal cortical dysplasia? | {
"contexts": [
"Focal cortical dysplasia (FCD) is able to generate an intrinsic pathological EEG activity characterized by a continuous or near-continuous spiking. Different patterns of discharge were described. We examined quantitatively the distribution of the intracerebral FCD patterns in relation to sleep in... | Despite the presence of an almost continuous discharge, sleep is an important modulator of the pathological EEG patterns found in FCD type II. This might suggest that dysplastic tissue is influenced by the thalamo-cortical control mechanisms involved in the generation of sleep. | yes |
25,967,967 | Does autophagy protect renal tubular cells against ischemia / reperfusion injury in a time-dependent manner? | {
"contexts": [
"Autophagy is a dynamic catabolic process that maintains cellular homeostasis. Whether it plays a role in promoting cell survival or cell death in the process of renal ischemia/reperfusion (I/R) remains controversial, partly because renal autophagy is usually examined at a certain time point. Ther... | Autophagy was induced in a time-dependent manner and occurred earlier than the onset of cell apoptosis as an early response that played a renoprotective role during renal I/R and cell H/R. Up-regulation of autophagy may prove to be a potential strategy for the treatment of acute kidney injury. | yes |
25,967,962 | Does chronic-leptin attenuate Cisplatin cytotoxicity in MCF-7 breast cancer cell line? | {
"contexts": [
"Large-scale epidemiological studies support a correlation between obesity and breast cancer in postmenopausal women. Circulating leptin levels are increased in obese and it has been suggested to play a significant role in mammary tumor formation and progression. Moreover, regulation of oxidative ... | Chronic leptin could contribute to the effective regulation of endogenous and treatment-induced oxidative stress, and it contributes to explain in part its proliferative effects. | yes |
25,976,600 | Does the Precision of Pulmonary Artery Catheter Bolus Thermodilution Cardiac Output Measurements vary With the Clinical Situation? | {
"contexts": [
"To investigate the effects of ventilatory mode, injectate temperature, and clinical situation on the precision of cardiac output measurements.",
"Randomized, prospective observational study.",
"Single university hospital.",
"Forty patients undergoing planned cardiac surgery, receiving... | Clinical precision of cardiac output measurements is reduced significantly during spontaneous relative to controlled ventilation. The differences in precision between repeated measurement series within the temperature/ventilation combinations indicate influence of other situation-specific factors not related to ventila... | yes |
25,982,666 | Is plasma heat shock protein 27 increased in renal dysfunction and habitual smoking in a Japanese general population? | {
"contexts": [
"Heat shock proteins (HSPs) work as \"chaperones\" to affect protein folding of newly synthesized or denatured proteins. HSP 27 plays an important role in coronary artery disease or renal disease as the result of oxidative stress. Although habitual smoking is well known to induce oxidative stress,... | The present study demonstrated that HSP 27 levels were strongly related to renal dysfunction and habitual smoking in a dose-response manner in a Japanese general population. | yes |
25,984,238 | Is occupancy by key transcription factors a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility? | {
"contexts": [
"Regulated gene expression controls organismal development, and variation in regulatory patterns has been implicated in complex traits. Thus accurate prediction of enhancers is important for further understanding of these processes. Genome-wide measurement of epigenetic features, such as histone m... | Occupancy by key transcription factors such as TAL1, GATA1, SMAD1, and EP300, along with evidence of transcription, improves the accuracy of enhancer predictions based on epigenetic features. | yes |
25,984,234 | Does automated nutrient screening system enable high-throughput optimisation of microalgae production conditions? | {
"contexts": [
"Microalgae provide an excellent platform for the production of high-value-products and are increasingly being recognised as a promising production system for biomass, animal feeds and renewable fuels.",
"Here, we describe an automated screen, to enable high-throughput optimisation of 12 nutri... | The screen identified the main nutrient effects on growth, pairwise nutrient interactions (for example, Ca-Mg) and the best production conditions of the sampled statistical space providing the basis for a targeted full factorial screen to assist with optimisation of algae production. | yes |
25,983,079 | Does a modified Glenn shunt reduce right ventricular stroke work during left ventricular assist device therapy? | {
"contexts": [
"Right ventricular (RV) failure is a major cause of morbidity and mortality after left ventricular assist device (LVAD) placement and remains hard to predict. We hypothesized that partial surgical exclusion of the RV with a modified Glenn shunt during LVAD treatment would reduce RV stroke work.",
... | A modified Glenn shunt reduced RV volumes, RV stroke work and RA pressure during LVAD therapy in an experimental model of heart failure in pigs. | yes |
25,982,299 | Does twice cutting method reduce tibial cutting error in unicompartmental knee arthroplasty? | {
"contexts": [
"Bone cutting error can be one of the causes of malalignment in unicompartmental knee arthroplasty (UKA). The amount of cutting error in total knee arthroplasty has been reported. However, none have investigated cutting error in UKA. The purpose of this study was to reveal the amount of cutting er... | Our study demonstrated that in UKA, cutting the tibia horizontally twice using the same cutting guide reduced cutting error in the coronal plane. | yes |
25,958,115 | Does preventive methylene blue treatment preserve cognition in mice expressing full-length pro-aggregant human Tau? | {
"contexts": [
"Neurofibrillary tangles (NFT) composed of Tau are hallmarks of neurodegeneration in Alzheimer disease. Transgenic mice expressing full-length pro-aggregant human Tau (2N4R Tau-ΔK280, termed Tau(ΔK)) or its repeat domain (TauRD-ΔK280, TauRD(ΔK)) develop a progressive Tau pathology with missorting,... | Our data support the use of Tau aggregation inhibitors as potential drugs for the treatment of AD and other tauopathies and highlights the need for preventive treatment before onset of cognitive impairments. | yes |
25,962,972 | Are pragmatic characteristics of patient-reported outcome measures important for use in clinical practice? | {
"contexts": [
"Measures for assessing patient-reported outcomes (PROs) that may have initially been developed for research are increasingly being recommended for use in clinical practice as well. Although psychometric rigor is essential, this article focuses on pragmatic characteristics of PROs that may enhance... | Balancing psychometric and pragmatic factors in the development of PROs is important for accelerating the incorporation of PROs into clinical practice. | yes |
25,981,050 | Does clipping of tumour resection margins allow accurate target volume delineation in head and neck cancer adjuvant radiation therapy? | {
"contexts": [
"Accurate tumour bed localisation is a key requirement for adjuvant radiotherapy. A new procedure is described for head and neck cancer treatment that improves tumour bed localisation using titanium clips.",
"Following complete local excision of the primary tumour, the tumour bed was marked wi... | We demonstrate a precise delineation of the former tumour cavity. Improvements in tumour bed delineation allow an increase of accuracy for adjuvant treatment. | yes |
25,964,448 | Does boredom proneness predict quality of life in outpatients diagnosed with schizophrenia-spectrum disorders? | {
"contexts": [
"There is increasing recognition of the clinical significance of boredom associated with functional impairments in schizophrenia. Previous work has highlighted the importance of motivational deficits more broadly, although no study has yet explored the unique effects of boredom on community outcom... | This pattern of unique effects on quality of life highlights the clinical relevance of identifying a subjective state of boredom and has theoretical importance in distinguishing boredom proneness specifically from more general avolitional and amotivational conditions that have tended to be the focus of clinical observa... | yes |
25,975,047 | Do frequency steps and compositions determine properties of nee- dling sensation during electroacupuncture? | {
"contexts": [
"To investigate the relationship of electro-parameters and the electroacupuncture sensation (EAS), which is thought to be an important factor for optimal treatment.",
"The frequency steps and compositions of three frequently used electrical stimulations were set when the switch of the electroa... | The greater the frequency step of the electroacupuncture stimulation, the longer the needling sensation lasted. The electroacupuncture stimulations of the DD3 group were unsuitable for the facial acupoint because of its painful and uncomfortable EAS, but more suitable for the back acupoint. | yes |
25,983,101 | Does aNXA1 silencing increase the sensitivity of cancer cells to low-concentration arsenic trioxide treatment by inhibiting ERK MAPK activation? | {
"contexts": [
"Arsenic trioxide (ATO), an antitumor agent, is widely used for treating acute promyelocytic leukemia (APL), in which it induces apoptosis. In most solid tumors, ATO disturbs the cell cycle instead of inducing apoptosis. We aimed to determine the exact mechanism underlying the different response o... | Taken together, these data indicate that overexpression of ANXA1 induced by low-concentration ATO makes cancer cells more resistant to the agent via activated ERK MAPKs. Specific silencing of ANXA1 increased the sensitivity of cancer cells to ATO treatment. | yes |
25,988,730 | Does topical dexamethasone-cyclodextrin nanoparticle eye drop for non-infectious Uveitic macular oedema and vitritis - a pilot study? | {
"contexts": [
"To evaluate the safety and efficacy of 1.5% dexamethasone nanoparticle (DexNP) drops in eyes with non-infectious uveitic macular oedema and vitritis.",
"In a prospective pilot study, DexNP drops were administered four times a day for 4 weeks followed by drops tapering over a period of another... | This short pilot study demonstrates favourable effect of 1.5% DexNP eye drops on eyes with non-infectious uveitic macular oedema and vitritis. Further comparative long-term studies are warranted to assess this effect. | yes |
25,962,802 | Does temporal-component analysis of diastolic electrograms in ventricular tachycardia differentiate nonvulnerable regions of the circuit? | {
"contexts": [
"Successful activation mapping of ventricular tachycardia (VT) is dependent on the identification of a region of diastolic conduction by use of point-by-point sequential mapping. It is important to identify the site of transition from diastolic conduction to systolic activation of healthy myocardi... | Our analysis suggests that temporal-component analysis of diastolic electrograms during activation mapping of VT provides a practical method to differentiate nonvulnerable sites from the exit site without the need for pacing maneuvers. | yes |
25,961,724 | Does post-operative plasma osteopontin predict distant metastasis in human colorectal cancer? | {
"contexts": [
"The overall prognosis of colorectal cancer (CRC) patients is unsatisfactory due to cancer metastasis after operation. This study aims to investigate the clinical significance of plasma osteopontin (OPN) levels as minimally invasive, predictive, and surrogate biomarkers for prognosis of CRC patien... | The results of the current study suggest that post-operative plasma OPN correlated with post-operative metastasis, suggesting that it is a potential non-invasive biomarker for the development of future metastasis in CRC patients. In addition, OPN was shown to be involved in the metastatic process and thus inhibition of... | yes |
25,963,383 | Are not all gleason pattern 4 prostate cancers created equal : A study of latent prostatic carcinomas in a cystoprostatectomy and autopsy series? | {
"contexts": [
"The Gleason grading system represents the cornerstone of the management of prostate cancer. Gleason grade 4 (G4) is a heterogeneous set of architectural patterns, each of which may reflect a distinct prognostic value.",
"We determined the prevalence of the various G4 architectural patterns an... | Our study revealed that in latent prostate cancer both cribriform architecture and IDC are uniquely associated with poor pathological outcome features. In contrast, Gleason score 7 (3 + 4) cancers with small-fused gland pattern might possibly include some prostate cancers with a more indolent biology. | yes |
25,976,154 | Are serum IL-33 levels increased in patients with psoriasis? | {
"contexts": [
"Interleukin (IL)-33 is a recently identified cytokine, which is a member of the IL-1 family and binds to a heterodimeric receptor comprising ST2 (suppression of tumorigenicity 2) and IL-1 receptor accessory protein. Serum levels of IL-33 have been reported to be upregulated in various T helper (T... | These results suggest that serum IL-33 levels generally reflect increased inflammation in patients with psoriasis. | yes |
25,984,239 | Does gene expression profiling reveal potential prognostic biomarkers associated with the progression of heart failure? | {
"contexts": [
"Heart failure (HF) is the most common cause of morbidity and mortality in developed countries. Here, we identify biologically relevant transcripts that are significantly altered in the early phase of myocardial infarction and are associated with the development of post-myocardial infarction HF.",... | This study demonstrates an altered gene expression profile in PBMCs during acute myocardial infarction and through the follow-up. The identified gene expression changes at the early phase of STEMI that differentiated the patients who developed HF from those who did not could serve as a convenient tool contributing to t... | yes |
25,961,971 | Does pharmacotherapy with 17β-estradiol and progesterone prevent development of mouse experimental autoimmune encephalomyelitis? | {
"contexts": [
"Pregnant women with multiple sclerosis (MS) show disease remission in the third trimester concomitant with high circulating levels of sex steroids. Rodent experimental autoimmune encephalomyelitis (EAE) is an accepted model for MS. Previous studies have shown that monotherapy with estrogens or pr... | Cotherapy with estrogen and progesterone inhibits the development of major neurochemical abnormalities and clinical signs of EAE. We suggest that a combination of neuroprotective, promyelinating and immuno-suppressive mechanisms are involved in these beneficial effects. | yes |
25,976,624 | Does high Expression of GRP78 promote Invasion and Metastases in Patients with Esophageal Squamous Cell Carcinoma? | {
"contexts": [
"Esophageal squamous cell carcinoma (ESCC) has a poor prognosis due to its high frequency of metastasis and invasion. Recent studies have suggested glucose-regulated protein 78KD (GRP78) may play important roles in progression and development of malignant tumors. However, the mechanisms of invasio... | The present study demonstrated that GRP78 plays important roles in invasion and metastasis of ESCC, indicating that GRP78 might be used as a potential prognostic and therapeutic marker in patients with ESCC by modulating the expression of MMP-2 and MMP-9. | yes |
25,970,232 | Are patients with single ventricle physiology undergoing noncardiac surgery at high risk for adverse events? | {
"contexts": [
"Patients with single ventricle physiology are at increased anesthetic risk when undergoing noncardiac surgery.",
"To review the outcomes of anesthetics for patients with single ventricle physiology undergoing noncardiac surgery.",
"This study is a retrospective chart review of all patient... | We observed no mortality during or after noncardiac surgery in a high-risk subgroup of palliated cardiac patients with single ventricle physiology. However, 11.8% of patients had an adverse event associated with their anesthetic. | yes |
25,960,087 | Is the histone deacetylase sirtuin 2 a new player in the regulation of platelet function? | {
"contexts": [
"Histone deacetylases (HDACs) play a key role in signaling in many cell types. However, little is known about the participation of HDACs, particularly sirtuins (SIRTs), in platelet reactivity.",
"To investigate the role of HDACs in platelets, we examined the effects of SIRT inhibition on plate... | Regulation of protein acetylation by SIRT2 plays a central role in platelet function. The effects of SIRT2 are mediated in part by the acetylation and inhibition of Akt. These results open a new avenue for research into the control of platelet function, and may help to identify new therapeutic targets. | yes |
25,963,574 | Are escherichia coli isolates from patients with bacteremic urinary tract infection genetically distinct from those derived from sepsis following prostate transrectal biopsy? | {
"contexts": [
"Transrectal ultrasound-guided (TRUS) prostate biopsy is a very common procedure that is generally considered relatively safe. However, severe sepsis can occur after TRUS prostate biopsies, with Escherichia coli being the predominant causative agent. A common perception is that the bacteria that c... | Our finding supports the hypothesis that E. coli causing PPBS derive directly from the rectum, bypassing the urinary tract, and therefore do not require many of the virulence capabilities necessary for an E. coli strain that must persist in the urinary tract. In light of the increasing prevalence of highly resistant E.... | yes |
25,981,557 | Do exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine-induced apoptosis? | {
"contexts": [
"Stem cells derived from the dental pulp of human exfoliated deciduous teeth (SHEDs) have unique neurogenic properties that could be potentially exploited for therapeutic use. The importance of paracrine SHED signaling for neuro-regeneration has been recognized, but the exact mechanisms behind the... | Our results suggest that exosomes derived from SHEDs are considered as new potential therapeutic tool in the treatment of Parkinson's disease. | yes |
25,981,452 | Do virologically suppressed patients with asymptomatic and symptomatic HIV-associated neurocognitive disorders display the same pattern of immune activation? | {
"contexts": [
"Inversion of the CD4:CD8 ratio is a marker of immune activation and age-associated disease. We measured the CD4:CD8 ratio as a marker of cognitive impairment in HIV-infected patients and explored differences according to clinical severity.",
"Post hoc analysis of data from two prospective coh... | Aviraemic patients with sHAND did not display the same pattern of immune activation as subjects with ANI, suggesting that the underlying pathophysiological mechanisms could be different. | no |
25,967,734 | Is oxidative DNA damage involved in cigarette smoke-induced lung injury in rats? | {
"contexts": [
"Reactive oxygen species (ROS) induced by exogenous toxicants are suggested to be involved in carcinogenesis by oxidative modification of DNA. 8-Hydroxyl-2-deoxyguanosine (8-OHdG) has been considered as a reliable biomarker for oxidative DNA damage both in vivo and in vitro studies. But the effect... | These findings indicate that long-term exposure to cigarette smoker increases ROS levels, decreases total antioxidant capacity, and interferes DNA repair capacity that eventually induces oxidative DNA damage, which appears to play an important role in cigarette smoke-induced lung injury in rats, and determination of 8-... | yes |
25,987,048 | Is aLCAM a Novel Cytoplasmic Membrane Protein in TNF-α Stimulated Invasive Cholangiocarcinoma Cells? | {
"contexts": [
"Cholangiocarcinoma (CCA), or bile duct cancer, is incurable with a high mortality rate due to a lack of effective early diagnosis and treatment. Identifying cytoplasmic membrane proteins of invasive CCA that facilitate cancer progression would contribute toward the development of novel tumor mark... | This study indicated that ALCAM may be a novel protein candidate expressed on cytoplasmic membranes of invasive CCA cells that could be used as a biomarker for development of diagnosis, prognosis, and drug or antibody-based targeted therapies in the future. | yes |
25,986,493 | Is intrathoracic anastomotic leakage after gastroesophageal cancer resection associated with increased risk of recurrence? | {
"contexts": [
"Intrathoracic anastomotic leakage after intended curative resection for cancer in the esophagus or gastroesophageal junction has a negative impact on long-term survival. The aim of this study was to investigate whether an anastomotic leakage was associated with an increased recurrence rate.",
... | Intrathoracic anastomotic leakage increased the risk of recurrence in patients who underwent curative gastroesophageal cancer resection. | yes |
25,983,220 | Do microvascular free tissue transfer in acute and secondary burn reconstruction? | {
"contexts": [
"The mainstay of operative treatment in burns is split skin grafting with free tissue transfer being indicated in a minority of cases. However, free tissue transfer faces a number of challenges in the burns patient. These include; overall cardiovascular and respiratory stability of the patient, av... | Free tissue transfer has a small but definite role within acute and secondary burn reconstruction surgery. Despite the complexity of the burn defects involved, free flaps appear to have a high success rate within this cohort of patients. This appears to be the case as long as the appropriate patient and flap is selecte... | yes |
25,986,306 | Is high DHEAS/free testosterone ratio related to better metabolic parameters in women with PCOS? | {
"contexts": [
"To demonstrate the effects of DHEAS/free testosterone (DHEAS/FT) ratio on metabolic parameters in women with and without polycystic ovary syndrome (PCOS).",
"The data of 91 women with PCOS and 66 women in the control group were collected retrospectively.",
"DHEAS/FT of the control group w... | High DHEAS/FT ratios are related to a better metabolic phenotype in women with PCOS and low levels can be used to detect women with PCOS that have a higher risk of metabolic problems. | yes |
25,977,341 | Does pHLPP2 Downregulation contribute to Lung Carcinogenesis Following B [ a ] P/B [ a ] PDE Exposure? | {
"contexts": [
"The carcinogenic capacity of B[a]P/B[a]PDE is supported by epidemiologic studies. However, the molecular mechanisms responsible for B[a]P/B[a]PDE-caused lung cancer have not been well investigated. We evaluated here the role of novel target PHLPP2 in lung inflammation and carcinogenesis upon B[a]... | Our studies not only first time identify PHLPP2 downregulation by lung carcinogen B[a]P/B[a]PDE, but also elucidate a novel molecular mechanisms underlying lung inflammation and carcinogenesis upon B[a]P/B[a]PDE exposure. | yes |
25,977,345 | Does pharmacologic Inhibition of JAK1/JAK2 Signaling reduce Experimental Murine Acute GVHD While Preserving GVT Effects? | {
"contexts": [
"Immune-mediated graft-versus-tumor (GVT) effects can occur after allogeneic hematopoietic stem cell transplantation (HSCT), but GVT is tightly linked to its main complication, graft-versus-host disease (GVHD). Strategies aimed at modulating GVHD, while maintaining the GVT effect, are needed to im... | These data provide further evidence that JAK inhibition represents a new and potentially clinically relevant approach to GVHD prevention. | yes |
25,962,372 | Are vegetable dishes , dairy products and fruits key items mediating adequate dietary intake for Japanese adults with spinal cord injury? | {
"contexts": [
"This is a cross-sectional study.",
"The objective of this study was to ascertain the essential items mediating adequate dietary intake based on the Japanese Food Guide in common among the transtheoretical model (TTM), self-efficacy (SE) and outcome expectancy (OE).",
"Members of the organ... | This study finds that vegetable dishes, dairy products and fruits are the key items mediating adequate dietary intake. Dietary guidelines promoting the intake of these dishes for SCI individuals are needed. | yes |
25,987,031 | Is radiotherapy Alone Associated with Improved Outcomes Over Surgery in the Management of Solitary Plasmacytoma? | {
"contexts": [
"A moderate dose of radiation is the recommended treatment for solitary plasmacytoma (SP), but there is controversy over the role of surgery. Our study aimed at comparing different treatment modalities in the management of SP.",
"Data from 38 consecutive patients with solitary plasmacytoma, in... | Radiotherapy alone can be considered as a more effective treatment for SP over surgery. Whether a combination of radiotherapy and surgery improves outcomes requires further study. | yes |
25,977,572 | Is increases in physical activity as important as smoking cessation for reduction in total mortality in elderly men : 12 years of follow-up of the Oslo II study? | {
"contexts": [
"Physical activity (PA) at leisure by the elderly, and its relationship to cardiovascular (CV) and non-CV mortality, with and without competing risk, has been scarcely described. We determined the relationships between PA, smoking and 12-year CV, non-CV and all-cause mortality in elderly Oslo men ... | Even at the age of 73 years, PA is associated highly with mortality between groups of sedentary and active persons. Allowing for competing risk did not weaken these associations markedly. Public health strategies in elderly men should include efforts to increase PA in line with efforts to reduce smoking behaviour. | yes |
25,977,570 | Does systems Genetics Analysis of Genome-Wide Association Study reveal Novel Associations Between Key Biological Processes and Coronary Artery Disease? | {
"contexts": [
"Genome-wide association studies have identified multiple genetic variants affecting the risk of coronary artery disease (CAD). However, individually these explain only a small fraction of the heritability of CAD and for most, the causal biological mechanisms remain unclear. We sought to obtain fu... | These findings provide novel insights into how genetic variation, interpreted in the context of biological processes and functional interactions among genes, may help define the genetic architecture of CAD. | yes |
25,982,447 | Does microRNA-19a regulate lipopolysaccharide-induced endothelial cell apoptosis through modulation of apoptosis signal-regulating kinase 1 expression? | {
"contexts": [
"MicroRNAs, small non-encoding RNAs that post-transcriptionally modulate expression of their target genes, have been implicated as critical regulatory molecules in endothelial cells.",
"In the present study, we found that overexpression of miR-19a protects endothelial cells from lipopolysaccha... | MiR-19a regulates ASK1 expression by targeting specific binding sites in the 3' untranslated region of ASK1 mRNA. Overexpression of miR-19a is an effective method to protect against LPS-induced apoptosis of endothelial cells. | yes |
25,970,966 | Do imidazoline receptor antagonists idazoxan and efaroxan enhance locomotor functions in rats? | {
"contexts": [
"Discovered in 1984, imidazoline receptors (I1, I2, I3) are located centrally and peripherally being involved in various physiologic and pathophysiologic processes in the body. Experimental and clinical investigations have suggested the interrelations between imidazoline, adrenergic, dopaminergic,... | In our experimental conditions we demonstrated the ability of imidazoline receptor antagonists idazoxan and efaroxan to improve fatigue resistance during forced running in rats. | yes |
25,963,193 | Is metabolic syndrome associated with better prognosis in patients with tongue squamous cell carcinoma? | {
"contexts": [
"Metabolic syndrome (MS) is associated with several cancers, but it is not clear whether MS affects the prognosis of tongue squamous cell carcinoma (TSCC). This study aimed to evaluate the prognostic value of MS in TSCC.",
"Clinical data from 252 patients with TSCC who were initially treated a... | MS is associated with early N category in TSCC. It is an independent prognostic factor for better survival in patients with TSCC. | yes |
25,979,462 | Does tourniquet use during ankle surgery lead to increased postoperative opioid use? | {
"contexts": [
"Ankle surgery is often done using a tourniquet. Ischemia/reperfusion injury caused by the tourniquet may increase postoperative pain. The study objective was to investigate the amount of opioids given to patients after ankle surgery with and without tourniquet.",
"We did a cohort study based ... | We found an increase in postoperative opioid consumption correlated to tourniquet use. Possible preventive measures with antioxidant treatment to prevent ischemia/reperfusion injury should be investigated. | yes |
25,978,725 | Does mfn2 affect Embryo Development via Mitochondrial Dysfunction and Apoptosis? | {
"contexts": [
"Growth factors, energy sources, and mitochondrial function strongly affect embryo growth and development in vitro. The biological role and prospective significance of the mitofusin gene Mfn2 in the development of preimplantation embryos remain poorly understood. Our goal is to profile the role of... | Low in vitro expression of Mfn2 attenuates the blastocyst formation rate and cleavage speed in mouse zygotes and causes mitochondrial dysfunction, as confirmed by the ATP and mtDNA levels and mitochondrial membrane potential. Mfn2 deficiency induced apoptosis through the Bcl-2/Bax and Ca(2+) pathways. These findings in... | yes |
25,975,424 | Is the chemokine CXCL13 elevated in the cerebrospinal fluid of patients with neurosyphilis? | {
"contexts": [
"The chemokine CXCL13 has been discussed as a diagnostic parameter with high specificity for Lyme neuroborreliosis (LNB) and as a marker of disease activity. Neurosyphilis and LNB share similar characteristics. We investigated retrospectively CXCL13 levels in the cerebrospinal fluid (CSF) of patie... | CXCL13 levels in the CSF of patients with neurosyphilis can be as high as in patients with LNB, exceeding the proposed threshold of 250 pg/mL for the diagnosis of LNB. Patients with encephalitic/myelitic syndromes appear to have especially high levels of CXCL13. Clinicians should be aware that high levels of CXCL13 are... | yes |
25,960,541 | Are wA29 '' we all one '' compassionate cities `` a global community joined for care ''? | {
"contexts": [
"The NewHealth Foundation, a Spanish non-for-profit organisation, is leading the project Compassionate Cities. \"We are all one\". The project aims to involve citizens in creating communities of care to help people at the end of life phase.",
"To design and develop a practical model to engage ... | This model supports people to become the real co-producers of services, as they know which services best respond to their needs. | yes |
25,972,151 | Does hesperetin induce the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species? | {
"contexts": [
"Hesperetin, has been shown to exert biological activities on various types of human cancers. However, few related studies on gastric cancer are available.",
"In this study, we sought to investigate the effect of hesperetin on gastric cancer and clarify its specific mechanism.",
"Cell Coun... | Our study suggests that hesperetin could inhibit the proliferation and induce the apoptosis of gastric cancer cells via activating the mitochondrial pathway by increasing the ROS. | yes |
25,963,016 | Do high prevalence of CDH23 mutations in patients with congenital high-frequency sporadic or recessively inherited hearing loss? | {
"contexts": [
"Mutations in CDH23 are responsible for Usher syndrome 1D and recessive non-syndromic hearing loss. In this study, we revealed the prevalence of CDH23 mutations among patients with specific clinical characteristics.",
"After excluding patients with GJB2 mutations and mitochondrial m.1555A > G ... | These results revealed that CDH23 mutations are highly prevalent in patients with congenital high-frequency sporadic or recessively inherited hearing loss and that the mutation spectrum was diverse, indicating that patients with these clinical features merit genetic analysis. | yes |
25,985,404 | Do hair concentrations of antiretrovirals predict viral suppression in HIV-infected pregnant and breastfeeding Ugandan women? | {
"contexts": [
"Hair concentrations are a noninvasive measure of cumulative antiretroviral exposure and the strongest predictor of viral suppression in large cohorts of nonpregnant patients. We examined hair concentrations of antiretrovirals in relation to virologic outcomes in pregnant and breastfeeding women f... | Antiretroviral hair concentrations represent an innovative tool that strongly predicts viral suppression among HIV-infected childbearing women during the critical periods of delivery and breastfeeding. | yes |
25,987,467 | Does a default normal chest CT structured reporting field for coronary calcifications cause excessive false-negative reporting? | {
"contexts": [
"The aim of this study was to compare the accuracy of coronary atherosclerosis reporting before and after the implementation of a structured reporting chest CT template.",
"A noncardiac, noncontrast chest CT structured reporting template was developed and mandated for department-wide use at a ... | Implementing a structured reporting template improves reporting accuracy of coronary calcifications. | no |
25,976,614 | Do mR imaging findings of ovarian torsion correlate with pathological hemorrhagic infarction? | {
"contexts": [
"The aim of this study was to clarify the magnetic resonance (MR) imaging findings, including diffusion-weighted imaging (DWI), of hemorrhagic infarction of ovarian torsion.",
"Twelve patients presenting surgically confirmed ovarian masses with torsion were independently evaluated by two radio... | Pathological hemorrhagic infarction of ovarian torsion was associated with several MR imaging findings, including high signal intensity on T1WI/DWI, and irregular wall thickening on T2WI. | yes |
25,982,653 | Does central pulse pressure predict BP reduction after renal denervation in patients with treatment-resistant hypertension? | {
"contexts": [
"Enhanced vascular ageing is associated with elevated central pulse pressure (cPP), an independent predictor of cardiovascular (CV) events. Although antihypertensive treatment strategies are effective, high residual CV risk remains indicative of advanced and largely irreversible vascular damage. R... | Our data suggest that cPP, indicative of the degree of large arterial stiffening, may be helpful to identify responders to RDN. | yes |
25,969,563 | Does hIV-1 Infection accelerate Age According to the Epigenetic Clock? | {
"contexts": [
"Infection with human immunodeficiency virus type 1 (HIV) is associated with clinical symptoms of accelerated aging, as evidenced by the increased incidence and diversity of age-related illnesses at relatively young ages and supporting findings of organ and cellular pathologic analyses. But it has... | Overall, our results demonstrate that the epigenetic clock is a useful biomarker for detecting accelerated aging effects due to HIV infection. This tool can be used to accurately determine the extent of age acceleration in individual tissues and cells. | yes |
25,961,355 | Does estetrol prevent and suppresses mammary tumors induced by DMBA in a rat model? | {
"contexts": [
"Estetrol (E4) is a pregnancy-specific estrogenic steroid hormone produced by the human fetal liver in both male and female fetuses. During pregnancy, E4 plasma values increase exponentially until parturition and decrease thereafter. The synthesis of E4 in the liver of a newborn ceases during the ... | The natural fetal estrogen E4 prevents tumor initiation by DMBA and inhibits the growth of existing DMBA-induced tumors. | yes |
25,962,901 | Is thymic stromal lymphopoietin activation of basophils in patients with allergic asthma IL-3 dependent? | {
"contexts": [
"Thymic stromal lymphopoietin (TSLP) released after antigenic stimulation of allergic asthmatic airways is a key initiator of type 2 inflammation. Basophils are important effectors of allergic inflammation in the airways. Murine basophils have been shown to respond to TSLP independently of IL-3 by... | Our findings indicate that basophil activation during early- and late-phase responses to inhaled allergen might be driven at least in part by TSLP. | yes |
25,962,903 | Does prostaglandin E2 inhibit mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor? | {
"contexts": [
"Inhaled prostaglandin (PG) E2 might inhibit asthmatic responses, but the mechanisms involved remain undefined.",
"We sought to characterize the direct and indirect effects of PGE2 on human small airways with particular reference to the receptors mediating the responses.",
"Contraction and... | The pharmacology of PGE2 in isolated human small airways was different from its profile in animal models. This first demonstration of powerful EP2 receptor-mediated inhibition of IgE-dependent contractions in human airways introduces a new selective target for the treatment of asthma. This EP2 control of mast cell-medi... | yes |
25,962,902 | Do skin dendritic cells induce follicular helper T cells and protective humoral immune responses? | {
"contexts": [
"The contribution of individual subsets of dendritic cells (DCs) to generation of adaptive immunity is central to understanding immune homeostasis and protective immune responses.",
"We sought to define functions for steady-state skin DCs.",
"We present an approach in which we restrict ant... | These data demonstrate that a major unappreciated function of skin DCs is their promotion of TFH cells and humoral immune responses that potentially represent an efficient approach for vaccination. | yes |
25,978,169 | Does the Selective Sirtuin 1 Activator SRT2104 reduce Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans? | {
"contexts": [
"Sirtuin 1 influences gene expression and other cellular functions through deacetylation of histone and nonhistone proteins. We here sought to determine the effects of a small molecule sirtuin 1 activator, SRT2104, on inflammation and coagulation induced by lipopolysaccharide in humans.",
"A r... | This is the first human study to demonstrate biological anti-inflammatory and anticoagulant responses consistent with the activation of sirtuin 1 by a small molecule. | yes |
25,973,133 | Does ultrasound-mediated microbubble destruction enhance the therapeutic effect of intracoronary transplantation of bone marrow stem cells on myocardial infarction? | {
"contexts": [
"The combination of intracoronary transplantation and ultrasound-mediated microbubble destruction may promote effective and accurate delivery of bone marrow stem cells (BMSCs) into the infarct zone. To test this hypothesis in this study we examined the effectiveness of ultrasound-mediated microbub... | Ultrasound-mediated microbubble destruction increases the homing of BMSCs in the target area following intracoronary transplantation, which allows more BMSCs to differentiate into functional cardiomyocytes, thereby reducing myocardial infarct size and improving cardiac function. | yes |
25,963,979 | Do human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation? | {
"contexts": [
"Keratins 8 and 18 (K8/K18) are the intermediate filaments proteins of simple-type digestive epithelia and provide important cytoprotective function. K8/K18 variants predispose humans to chronic liver disease progression and poor outcomes in acute acetaminophen (APAP)-related liver failure. Given ... | Expression of human K8 variants G62C, R341H, or R341C in mice predisposes to acute APAP hepatotoxicity, thereby providing direct evidence for the importance of these variants in human acute liver failure. | yes |
25,976,722 | Does implementation of a standardized postanesthesia care handoff increase information transfer without increasing handoff duration? | {
"contexts": [
"In the transition of a patient from the operating room (OR) to the postanesthesia care unit (PACU), it was hypothesized that (1) standardizing the members of sending and receiving teams and (2) requiring a structured handoff process would increase the overall amount of patient information transfe... | A standardized, team-based approach to OR-to-PACU handoffs increased the quantity of patient information transferred, increased PACU nurse satisfaction, and did not increase the handoff duration. | yes |
25,968,637 | Does cellular immunotherapy as maintenance therapy prolong the survival of the patients with small cell lung cancer? | {
"contexts": [
"Small cell lung cancer (SCLC) relapses rapidly after the initial response to chemotherapy and shows drug-resistance. This study was to investigate the efficacy and safety of cellular immunotherapy (CIT) with autologous natural killer (NK), γδT, and cytokine-induced killer (CIK) cells as maintenan... | CIT maintenance therapy in SCLC prolonged survival with only minimal side effects. Integrating CIT into current treatment may be a novel strategy for SCLC therapy, although further multi-center randomized studies are needed. | yes |
25,958,796 | Does family accommodation mediate the association between anxiety symptoms in mothers and children? | {
"contexts": [
"The link between child anxiety and maternal anxiety has been well established but the factors underlying this association are not well understood. One potential factor is family accommodation, which describes ways in which parents change their behaviour to help a child avoid or alleviate anxiety.... | These results inform theory and imply that the development of interventions designed to target family accommodation may improve the prognosis of those diagnosed with paediatric anxiety disorders and youth with subclinical anxiety symptoms by reducing both parent and child anxiety. | yes |
25,977,751 | Is antigen-induced airway hyperresponsiveness and obstruction related to caveolin-1 expression in airway smooth muscle in a guinea pig asthma model? | {
"contexts": [
"Caveolin-1 is a fundamental signalling scaffold protein involved in contraction; however, the role of caveolin-1 in airway responsiveness remains unclear. We evaluated the relationship between caveolin-1 expression in airway smooth muscle (ASM) and antigen-induced airway responsiveness and obstru... | Our data suggest that caveolin-1 expression in ASM has a crucial role in the development of antigen-induced airway obstruction and hyperresponsiveness in a guinea pig asthma model. In addition, the asthma model in guinea pigs appears to induce a contractile smooth muscle phenotype in the airways and a proliferative smo... | yes |
25,972,328 | Does low-cost workflow improvement reduce gastrointestinal block use 17 % by altering classic histotechnology testing? | {
"contexts": [
"Gastrointestinal (GI) biopsy specimens were previously limited to four per cassette to facilitate established internal technical work practices and histotechnology best practice guidelines. We evaluated the workflow of these biopsy specimens.",
"We implemented three specific changes: (1) up t... | This simple, low-cost, low-effort process change yielded immediate and significant time savings for grossing and histology staff, increased job satisfaction, and challenges conventional histotechnology teaching. | yes |
25,972,320 | Do flow cytometric identification of immunophenotypically aberrant T-cell clusters on skin shave biopsy specimens from patients with mycosis fungoides? | {
"contexts": [
"To assess the ability of flow cytometry (FC) to detect putative neoplastic T-cell subsets on skin shave biopsy (SSB) specimens from patients with mycosis fungoides (MF) and to study the immunophenotype of skin-infiltrating tumor cells in MF.",
"SSB specimens from patients with suspected MF we... | FC is capable of identifying putative neoplastic cells on SSB specimens from patients with MF. Bright homogeneous CD26 expression is a common and previously undescribed immunophenotypic aberrancy on MF skin infiltrates. | yes |
25,973,306 | Is a specific KRAS codon 13 mutation an independent predictor for colorectal cancer metachronous distant metastases? | {
"contexts": [
"In colorectal cancer, there are significant differences between synchronous and metachronous distant metastases. However in recent studies, synchronous and metachronous metastases were always lumped together, neglecting their clinical and molecular differences. The mechanism of the latency of met... | There were significant clinical and molecular differences between synchronous and metachronous metastases. As an independent predictor, KRAS codon 13 mutation might be the key to explain the mechanism of colorectal cancer metachronous distant metastases. Together with clinical characteristics, it could aid in the early... | yes |
25,986,864 | Is a Long Non-coding RNA Activated by Transforming Growth Factor-β an Independent Prognostic Marker of Gastric Cancer? | {
"contexts": [
"A recent study reported that long non-coding RNA activated by TGF-β (lncRNA-ATB) induced epithelial-mesenchymal transition (EMT) through the transforming growth factor-β (TGF-β)/miR-200s/ZEB axis in hepatocellular carcinoma. Herein, we focused on the clinical significance of lncRNA-ATB in gastric... | LncRNA-ATB plays an important role in EMT to promote invasion and metastasis through the TGF-β/miR-200s/ZEB axis, resulting in a poor prognosis in GC. LncRNA-ATB is a novel biomarker of lncRNA, indicative of a poor prognosis in GC patients. | yes |
25,986,865 | Is lymphatic Invasion an Independent Adverse Prognostic Factor in Patients with Colorectal Liver Metastasis? | {
"contexts": [
"For a selection of patients with colorectal liver metastases (CRLM), liver resection is a curative option. In order to predict long-term survival, clinicopathologic risk scores have been developed, but little is known about histologic factors and their prognostic value for disease-free and overal... | Intrahepatic lymphatic invasion, especially in combination with vascular invasion, is an important adverse prognostic factor for overall survival in patients with solitary CRLM after liver resection. | yes |
25,961,047 | Does african flora have the potential to fight multidrug resistance of cancer? | {
"contexts": [
"Continuous efforts from scientists of diverse fields are necessary not only to better understand the mechanism by which multidrug-resistant (MDR) cancer cells occur, but also to boost the discovery of new cytotoxic compounds to fight MDR phenotypes.",
"The present review reports on the contri... | African flora represents an enormous resource for novel cytotoxic compounds. To unravel the full potential, efforts should be strengthened throughout the continent, to meet the challenge of a successful fight against MDR cancers. | yes |
25,969,162 | Does constipation prophylaxis reduce length of stay in elderly hospitalized heart failure patients with home laxative use? | {
"contexts": [
"Elderly, hospitalized patients suffer disproportionately from constipation; however, little data suggest that constipation prophylaxis reduces length of stay (LOS). We performed a retrospective analysis of elderly patients admitted to our hospital with congestive heart failure (CHF) to determine ... | Among elderly patients admitted for CHF exacerbations, failure to use constipation prophylaxis in patients with home laxative use is associated with a significantly longer LOS. Our data suggest that routine use of bowel prophylaxis for elderly CHF patients with preexisting constipation may reduce LOS. | yes |
25,979,438 | Does gli1 promote transforming growth factor-beta1- and epidermal growth factor-induced epithelial to mesenchymal transition in pancreatic cancer cells? | {
"contexts": [
"The Hedgehog signaling pathway and its key target effector Gli1 are linked closely to the development of the epithelial to mesenchymal transition (EMT) in many cancers. The definite function of Gli1 in regulating the EMT of pancreatic cancer (PC), however, is still unclear.",
"At the cell and... | Gli1 silencing alone has no effect on EMT initiation; however, it exerts a protumor role in the aggressive invasion of PC cells by promoting TGFβ1- and EGF-induced EMT. | yes |
25,960,763 | Is existential security a necessary condition for continued breastfeeding despite severe initial difficulties : a lifeworld hermeneutical study? | {
"contexts": [
"The majority of new mothers in Sweden initiate breastfeeding and many experience initial difficulties. This experience is an important cause of early breastfeeding cessation. To increase understanding, there is a need to explore the lived experiences of the decision to continue or cease breastfee... | Existential security in the breastfeeding relationship seems to be an underlying factor for confidence and therefore a necessary condition for continued breastfeeding when having severe initial breastfeeding difficulties. Unresolved feelings of insecurity may be a serious barrier to further breastfeeding that can resul... | yes |
25,964,295 | Does polymorphism at 19q13.41 Predicts breast Cancer Survival Specifically after Endocrine Therapy? | {
"contexts": [
"Although most patients with estrogen receptor (ER)-positive breast cancer benefit from endocrine therapies, a significant proportion do not. Our aim was to identify inherited genetic variations that might predict survival among patients receiving adjuvant endocrine therapies.",
"We performed ... | Our findings suggest carrying the rs8113308 rare allele may identify patients who will not benefit from adjuvant endocrine treatment. | yes |
25,968,948 | Does insulin protect H9c2 rat cardiomyoblast cells against hydrogen peroxide-induced injury through upregulation of microRNA-210? | {
"contexts": [
"Insulin protects cardiomyocytes from reactive oxygen species (ROS)-induced apoptosis after ischemic/reperfusion injury, but the mechanism is not clear. This study investigated the protective mechanism of insulin in preventing cardiomyocyte apoptosis from ROS injury.",
"Rat cardiomyoblast H9c2... | Insulin stimulated the expression of miR-210 through the PI3K/Akt pathway, resulting in a protective effect against cardiomyocyte injury that had been induced by H2O2/oxygen species. Our results provide novel evidence regarding the mechanism underlying the protective effect of insulin. | yes |
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