pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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24,587,385 | Does sulforaphane inhibit invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells? | {
"contexts": [
"Glioblastoma has highly invasive potential, which might result in poor prognosis and therapeutic failure. Hence, the key we study is to find effective therapies to repress migration and invasion. Sulforaphane (SFN) was demonstrated to inhibit cell growth in a variety of tumors. Here, we will furt... | SFN inhibited migration and invasion processes. Furthermore, SFN inhibited invasion via activating ERK1/2 in a sustained way. The accumulated ERK1/2 activation downregulated MMP-2 expression and decreased its activity and upregulated CD44v6. SFN might be a potential therapeutic agent by activating ERK1/2 signaling agai... | yes |
24,602,260 | Is the location of origin of spontaneous extracranial internal carotid artery dissection adjacent to the skull base? | {
"contexts": [
"The traditional view is that spontaneous extracranial internal carotid artery (ICA) dissection (CAD) extends cranially from an intimal tear located just beyond the carotid bulb. This paper demonstrates that CAD originates in and primarily involves a more distal segment of the artery.",
"A ret... | CAD occurring spontaneously or due to indirect trauma most frequently involves the distal extracranial ICA. Spontaneous CAD is associated with vessel redundancy, and the risk of acute stroke is greatest with occlusive CAD. The prognosis is good with treatment, with a low rate of recurrent stroke and a high rate of vess... | yes |
24,613,182 | Does reverse total shoulder arthroplasty component center of rotation affect muscle function? | {
"contexts": [
"Medialization of the glenohumeral center of rotation alters the moment arm of the deltoid, can affect muscle function, and increases the risk for scapular notching due to impingement. The objective of this study was to determine the effect of position of the glenosphere on deltoid efficiency and ... | Selecting optimum placement of the glenosphere involves tradeoffs in bending moment at the implant-bone interface, risk for impingement, and deltoid efficiency. A viable option is partially medializing the glenosphere, which retains most of the benefits of deltoid efficiency and reduces the risk for scapular notching. | yes |
24,608,123 | Do associations of VEGF-C genetic polymorphisms with urothelial cell carcinoma susceptibility differ between smokers and non-smokers in Taiwan? | {
"contexts": [
"Vascular endothelial growth factor (VEGF)-C is associated with lymphangiogenesis, pelvic regional lymph node metastasis, and an antiapoptotic phenotype in urothelial cell carcinoma (UCC). Knowledge of potential roles of VEGF-C genetic polymorphisms in susceptibility to UCC is lacking. This study ... | Our results suggest that the involvement of VEGF-C genotypes in UCC risk differs among smokers compared to non-smokers among Taiwanese. The genetic polymorphism of VEGF-C rs7664413 might be a predictive factor for the tumor size of UCC patients who have a smoking habit. | yes |
24,615,483 | Is raloxifene pharmacodynamics influenced by genetic variants in the RANKL/RANK/OPG system and in the Wnt signaling pathway? | {
"contexts": [
"Raloxifene is a selective estrogen receptor (ER) modulator (SERM) used for the treatment of osteoporosis. However, its efficacy and also its safety vary greatly among treated patients, and it might be influenced by the individuals' genetic background. As the receptor activator of the nuclear fact... | We have shown that, in postmenopausal osteoporotic women treated with raloxifene, the efficacy of raloxifene treatment might be influenced by +34901G>A in TNFRSF11A gene and -1397_-1396insGGA in the SOST gene as well as -643C>T in TNFSF11 gene and +34694C>T in TNFRSF11A gene. However, these findings need additional fun... | yes |
24,594,218 | Does progesterone augment epirubicin-induced apoptosis in HA22T/VGH cells by increasing oxidative stress and upregulating Fas/FasL? | {
"contexts": [
"Although epirubicin, an anthracycline drug, is widely used to treat hepatocellular carcinoma, its therapeutic efficacy is disappointing. Thus, the efficacy of epirubicin may be improved when combined with other drugs. This study investigated the therapeutic potential of combination of progesteron... | Our observations suggest that progesterone enhances the efficacy of epirubicin. The increased efficacy is potentially attributed to progesterone's enhancement of epirubicin-induced oxidative stress, thereby reducing redox status. In addition, progesterone sequentially upregulates Fas/FasL to induce the caspase-8 and ca... | yes |
24,589,924 | Do immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation? | {
"contexts": [
"Infiltration of human melanomas with cytotoxic immune cells correlates with spontaneous type I IFN activation and a favorable prognosis. Therapeutic blockade of immune-inhibitory receptors in patients with preexisting lymphocytic infiltrates prolongs survival, but new complementary strategies are... | Using a genetically engineered mouse melanoma model, we demonstrate that targeted activation of the type I IFN system with immunostimulatory RNA in combination with blockade of immune-inhibitory receptors is a rational strategy to expose immune cell-poor tumors to cellular immune surveillance. | yes |
24,595,045 | Are coeliac patients undiagnosed at routine upper endoscopy? | {
"contexts": [
"Two out of three patients with Coeliac Disease (CD) in Australia are undiagnosed. This prospective clinical audit aimed to determine how many CD patients would be undiagnosed if duodenal biopsy had only been performed if the mucosa looked abnormal or the patient presented with typical CD symptoms... | Almost one quarter of new cases of CD presented with atypical symptoms and half of the new cases had unremarkable duodenal mucosa. At least 10% of new cases of celiac disease are likely to be undiagnosed at routine upper endoscopy, particularly patients over 60 years who more commonly present atypically. All new CD pat... | yes |
24,606,908 | Does porphyromonas gingivalis-induced autophagy suppress cell proliferation through G1 arrest in oral cancer cells? | {
"contexts": [
"We investigated the response of oral cancer cells to intracellular invasion of Porphyromonas gingivalis to define changes in the biological characteristics of oral cancer cells evoked by the presence of oral pathogenic bacteria within a tumour microenvironment.",
"The proliferative activity, ... | These findings provide a novel insight into the mechanism by which cancer cells are influenced by tumour microenvironment including oral bacteria. | yes |
24,586,936 | Does adverse lifestyle lead to an annual excess of 2 million deaths in China? | {
"contexts": [
"Adverse lifestyle factors have been associated with increased mortality, but data are lacking on their combined effect in developing populations, which we address in the present study.",
"In a death registry-based, case-control study among Hong Kong Chinese aged 30+y, proxy-reported lifestyle... | Adverse lifestyle factors contribute to one quarter of all deaths in China. Improving lifestyle practices, particularly focussing on moderating alcohol intake and increasing activity, and smoking cessation are critical to reducing the lifestyle-associated health burden. | yes |
24,613,070 | Are higher heart rate increments on head-up tilt in control subjects associated with autonomic dysfunction? | {
"contexts": [
"To determine whether there is altered autonomic function associated with elevated heart rate increments on head-up tilt (HUT) in younger individuals.",
"A total of 149 subjects were enrolled in this study. Subjects underwent the autonomic reflex screen including HUT and completed the Autonomi... | These results argue against a reduction in autonomic function underlying the higher heart rate increments seen on HUT in younger individuals. | no |
24,616,028 | Do altered developmental events in the anterior region of the chick forelimb give rise to avian-specific digit loss? | {
"contexts": [
"Avian forelimb (wing) contains only three digits, and the three-digit formation in the bird forelimb is one of the avian-specific limb characteristics that have been evolutionarily inherited from the common ancestral form in dinosaurs. Despite many studies on digit formation in the chick limb bud... | Forelimb-specific events in the anterior limb bud are possible developmental mechanisms that might generate the different cell fates in the fore- and hindlimb buds, regulating the number of digits in birds. | yes |
24,605,205 | Do three-dimensional accuracy of different correction methods for cast implant bars? | {
"contexts": [
"The aim of the present study was to evaluate the accuracy of three techniques for correction of cast implant bars.",
"Thirty cast implant bars were fabricated on a metal master model. All cast implant bars were sectioned at 5 mm from the left gold cylinder using a disk of 0.3 mm thickness, an... | There was no statistical significance among three techniques in horizontal, vertical and axial errors. But, gas-air torch soldering technique showed the most consistent and accurate trend in the correction of implant bar error. However, Laser welding technique, showed a large mean and standard deviation in vertical and... | yes |
24,603,716 | Are expression of genes related to anti-inflammatory pathways modified among farmers ' children? | {
"contexts": [
"The hygiene hypothesis states that children exposed to higher loads of microbes such as farmers' children suffer less from allergies later in life. Several immunological mechanisms underpinning the hygiene hypothesis have been proposed such as a shift in T helper cell balance, T regulatory cell a... | Farmers' children express multiple increased innate immune response and immune regulatory molecules, which may contribute to the mechanisms of action of the hygiene hypothesis. | yes |
24,597,653 | Does consumption of Coprinus comatus polysaccharide extract cause recovery of alcoholic liver damage in rats? | {
"contexts": [
"Excess use of alcohol is known to be associated with liver diseases such as fatty liver, alcoholic hepatitis, and cirrhosis. Various practices may be applied to prevent or treat the damage caused by chronic alcoholism. Coprinus comatus (O.F. Müll.) Pers. (Agaricaceae) is a macrofungus that has be... | Daily administration of 50 mg/kg of C. comatus PS extract considerably reduced the negative effects of alcohol on liver structure and function. | yes |
24,603,695 | Is a functionally significant polymorphism in ID3 associated with human coronary pathology? | {
"contexts": [
"We previously identified association between the ID3 SNP rs11574 and carotid intima-media thickness in the Diabetes Heart Study, a predominantly White diabetic population. The nonsynonymous SNP rs11574 results in an amino acid substitution in the C-terminal region of ID3, attenuating the dominant... | We present additional cohorts that demonstrate association of ID3 SNP rs11574 directly with human coronary artery pathology as measured by CAC and IVUS: one a multiethnic, relatively healthy population with low levels of diabetes and the second a predominantly White population with a higher incidence of T2DM referred f... | yes |
24,590,878 | Do early diagnosis of orthopedic implant failure using macromolecular imaging agents? | {
"contexts": [
"To develop and evaluate diagnostic tools for early detection of wear particle-induced orthopaedic implant loosening.",
"N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer was tagged with a near infrared dye and used to detect the inflammation induced by polymethylmethacrylate (PMMA) particles... | The results from this study demonstrate the feasibility of utilizing the macromolecular diagnostic agent to detect particle-induced peri-implant inflammation prior to the development of detectable osteolysis. Recognition of this early pathological event would provide the window of opportunity for prevention of peri-imp... | yes |
24,606,760 | Is interaction of translationally controlled tumor protein with Apaf-1 involved in the development of chemoresistance in HeLa cells? | {
"contexts": [
"Translationally controlled tumor protein (TCTP), alternatively called fortilin, is believed to be involved in the development of the chemoresistance of tumor cells against anticancer drugs such as etoposide, taxol, and oxaliplatin, the underlying mechanisms of which still remain elusive.",
"C... | TCTP protects the cancer cells from etoposide-induced cell death by inhibiting the mitochondria-mediated apoptotic pathway. Interaction of TCTP with Apaf-1 in apoptosome is involved in the molecular mechanism of TCTP-induced chemoresistance. These findings suggest that TCTP may serve as a therapeutic target for chemore... | yes |
24,604,568 | Does early postoperative patient-controlled analgesia ratio predict 24-hour morphine consumption and pain in children undergoing scoliosis surgery? | {
"contexts": [
"The identification of patients at risk for developing severe postoperative pain and/or opioid-related side effects is difficult due to a lack of sensitive indicators. The patient-controlled analgesia (PCA) ratio of demands to deliveries is a potential tool for early identification of patients who... | The authors have demonstrated that a PCA ratio of demands/deliveries ≥1.5 is predictive of increased opioid requirements and is associated with greater pain scores in the initial 24 hours after surgery, an increased incidence of opioid-related side effects, and duration of hospital stay. | yes |
24,612,312 | Is fut2 genotype a risk factor for dominant stenosis and biliary candida infections in primary sclerosing cholangitis? | {
"contexts": [
"A recent genome-wide association study identified the FUT2 secretor status and genotype defined by the single-nucleotide polymorphism rs601338 as potential genetic risk factor in primary sclerosing cholangitis (PSC), which significantly influences biliary bacterial composition.",
"To determin... | The rs601338-FUT2 genotype is strongly associated with episodes of cholangitis, fungobilia and the incidence of dominant stenosis, which are three clinical hallmarks of PSC; FUT2 is thus an important genetic risk factor for host-microbial diversity and disease progression in PSC. | yes |
24,591,982 | Do combination of swim-up and density gradient separation methods effectively eliminate DNA damaged sperm? | {
"contexts": [
"The aim of this experimental prospective study was to investigate the efficacy of single and combination sperm wash methods for their ability to isolate DNA intact spermatozoa.",
"Sperm DNA damage was introduced by local testicular irradiation in male mice and the extent of damage was quantif... | The combination of density gradient separation and swim-up method is effective in eliminating DNA damaged spermatozoa. | yes |
24,596,398 | Does interferon regulatory factor 3 protect against adverse neo-intima formation? | {
"contexts": [
"Vascular smooth muscle cell (VSMC) proliferation is central to the pathophysiology of neo-intima formation. Interferon regulatory factor 3 (IRF3) inhibits the growth of cancer cells and fibroblasts. However, the role of IRF3 in vascular neo-intima formation is unknown. We evaluated the protective... | IRF3 inhibits VSMC proliferation and neo-intima formation after vascular injury through PPARγ activation. | yes |
24,588,302 | Does podoplanin expression in cancer-associated fibroblasts predict aggressive behavior in melanoma? | {
"contexts": [
"Recent studies have showed podoplanin expression in several tumors, which has been associated with lymph node metastasis and poor prognosis. Podoplanin expression in cancer-associated fibroblasts also correlates with tumor progression. However, the association of podoplanin expression with melano... | The presence of podoplanin expression in cancer-associated fibroblasts correlates with aggressive behavior in melanoma and might therefore serve as a useful prognostic factor for patients with melanoma. | yes |
24,586,445 | Does the pandemic influenza A ( H1N1 ) 2009 vaccine increase the mortality rate of idiopathic interstitial pneumonia : a matched case-control study? | {
"contexts": [
"Evidence regarding the mortality rate after administration of the pandemic influenza A (H1N1) 2009 vaccine on patients with underlying diseases is currently scarce. We conducted a case-control study in Japan to compare the mortality rates of patients with idiopathic interstitial pneumonia after t... | In our study, we detected no evidence that the influenza A (H1N1) 2009 vaccine increased the mortality rate of patients with idiopathic interstitial pneumonia. The results, however, are limited by the small sample size and low statistical power. A larger-scale study is required. | no |
24,587,659 | Does sophocarpine attenuate liver fibrosis by inhibiting the TLR4 signaling pathway in rats? | {
"contexts": [
"To explore the effect of sophocarpine on experimental liver fibrosis and the potential mechanism involved.",
"Sophocarpine was injected intraperitoneally in two distinct rat hepatic fibrosis models induced either by dimethylnitrosamine or bile duct ligation. Masson's trichrome staining, Siriu... | Sophocarpine can alleviate liver fibrosis mainly by inhibiting the TLR4 pathway. Sophocarpine may be a potential chemotherapeutic agent for chronic liver diseases. | yes |
24,587,658 | Does diet high in fructose lead to an overexpression of lipocalin-2 in rat fatty liver? | {
"contexts": [
"To explore lipocalin-2 (LCN-2) expression and its possible role and mechanism(s) of production in rat models of diet-inducible fatty liver.",
"Fatty liver was triggered in male Sprague-Dawley rats fed either with liquid Lieber-DeCarli (LDC) or LDC + 70% cal fructose (L-HFr) diet for 4 or 8 wk... | Fructose diet up-regulates hepatic LCN-2 expression, which correlates with the increased indicators of oxidative stress and mitochondrial dysfunction. The LCN-2 may be involved in liver protection. | yes |
24,595,000 | Is gOLPH3 a novel marker of poor prognosis and a potential therapeutic target in human renal cell carcinoma? | {
"contexts": [
"Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was f... | These results suggest that GOLPH3 expression is likely to have important roles in RCC development and progression, and that GOLPH3 is a prognostic biomarker and a promising therapeutic target for RCC. | yes |
24,610,507 | Does atrial septal angulation vary widely in patients undergoing pulmonary vein isolation? | {
"contexts": [
"Transseptal puncture (TSP) allows left atrial access for curative procedures. Intracardiac echocardiography (ICE) provides direct visualization of the interatrial septum (IAS), but adds time and expense. We reviewed 100 cardiac multidetector computed tomography (MDCT) scans of patients undergoing... | The septal orientation in the axial plane varied widely and was not predicted by clinical variables such as atrial size or prior valve surgery. The high degree of interpatient variability observed suggests that direct visualization of the septum may be helpful in the performance of TSP. | yes |
24,589,179 | Does ischemic preconditioning improve liver tolerance to congestion-reperfusion injury in mice? | {
"contexts": [
"Congestion-reperfusion injury (CRI) is a common complication after living donor liver transplantation, which has not been fully understood. It causes more severe inflammatory response as compared with ischemia-reperfusion injury (IRI). Ischemic preconditioning (IPC) has been endowed with powerful... | IPC can significantly improve liver tolerance to CRI by attenuating neutrophil infiltration, proinflammatory cytokine formation, and hepatocytes apoptosis. This pretreatment strategy holds greater prospect of being translated into clinical use in living donor liver transplantation. | yes |
24,594,013 | Does interaction of acetylcholinesterase with neurexin-1β regulate glutamatergic synaptic stability in hippocampal neurons? | {
"contexts": [
"Excess expression of acetylcholinesterase (AChE) in the cortex and hippocampus causes a decrease in the number of glutamatergic synapses and alters the expression of neurexin and neuroligin, trans-synaptic proteins that control synaptic stability. The molecular sequence and three-dimensional stru... | Excessive glycosylated AChE could competitively disrupt a subset of the neurexin-neuroligin junctions consequently impairing the integrity of glutamatergic synapses. This might serve a molecular mechanism of excessive AChE induced neurodegeneration. | yes |
24,616,207 | Are macrophages and fibrosis in adipose tissue linked to liver damage and metabolic risk in obese children? | {
"contexts": [
"Obesity in childhood is associated with an inflammatory state in adipose tissue and liver, which elevates risk for diabetes and liver disease. No prior study has examined associations between pathologies occurring in adipose tissue and liver to identify elements of tissue damage associated with t... | Markers of subcutaneous white adipose tissue inflammation are associated with greater extent of liver fibrosis independent of obesity and SAT fibrosis may contribute to diabetes risk through reduced insulin secretion. | yes |
24,607,024 | Does long-term exposure to muscarinic agonists decrease expression of contractile proteins and responsiveness of rabbit tracheal smooth muscle cells? | {
"contexts": [
"Chronic airway diseases, like asthma or COPD, are characterized by excessive acetylcholine release and airway remodeling. The aim of this study was to investigate the long-term effect of muscarinic agonists on the phenotype and proliferation of rabbit tracheal airway smooth muscle cells (ASMCs)."... | Prolonged exposure of rabbit ASMCs to muscarinic agonists decreases the expression of smooth muscle specific marker proteins, down-regulates muscarinic receptors and decreases ASMC contractile responsiveness. Muscarinic agonists are mitogenic, via the PI3K and MAPK signalling pathways. | yes |
24,595,452 | Does lycium barbarum polysaccharide prevent focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice? | {
"contexts": [
"To investigate the neuroprotective effect of Lycium barbarum polysaccharide (LBP) on focal cerebral ischemic injury in mice and to explore its possible mechanism.",
"Male ICR mice were used to make the model of middle cerebral artery occlusion (MCAO) after intragastric administration with LBP... | Based on these findings we propose that LBP protects against focal cerebral ischemic injury by attenuating the mitochondrial apoptosis pathway. | yes |
24,591,767 | Does xuezhikang therapy increase miR-33 expression in patients with low HDL-C levels? | {
"contexts": [
"MicroRNA-33a and -b (miR-33a/b) have been revealed to be posttranscriptional regulators of HDL metabolism. Xuezhikang (XZK) is a marked natural HDL-raising polypill. We aim to evaluate the effects of XZK on the expression of circulating miR-33a/b in patients with low plasma HDL-C levels.",
"A... | In patients with low HDL-C levels, XZK therapy raised plasma levels of miR-33a and miR-33b, which may inhibit cellular cholesterol export and limit the HDL-raising effect of XZK. | yes |
24,608,398 | Do [ Endothelial cells promote islet survival and function ]? | {
"contexts": [
"To investigate islet graft survival and function after co-culture and co-transplantation with vascular endothelial cells (ECs) in diabetic rats.",
"We isolated ECs, and assessed the viability of isolated islets in a group of standard culture and a group of co-culture with ECs. Then we put the... | EC-islet co-culture can improve the function and survival of isolated islets in vitro, and EC-islet co-transplantation can effectively prolong the islet graft survival in diabetic rats. | yes |
24,597,478 | Is increased drug resistance associated with reduced glucose levels and an enhanced glycolysis phenotype? | {
"contexts": [
"The testing of anticancer compounds in vitro is usually performed in hyperglycaemic cell cultures, although many tumours and their in vivo microenvironments are hypoglycaemic. Here, we have assessed, in cultures of tumour cells, the effects of reduced glucose levels on resistance to anticancer dr... | Hypoglycaemia increased resistance to cytotoxic agents, especially in tumour cells with a high dependence on glycolysis. Dual inhibition of the PI3K/mTOR pathway may be able to attenuate such hypoglycaemia-associated resistance. | yes |
24,599,911 | Is iL-6-accelerated calcification by induction of ROR2 in human adipose tissue-derived mesenchymal stem cells STAT3 dependent? | {
"contexts": [
"The mechanisms of ectopic calcification in inflammatory diseases are poorly understood. We investigated the effects of inflammatory cytokines on the mechanisms of calcification in human adipose tissue-derived mesenchymal stem cells (hADSCs).",
"The effects of inflammatory cytokines were evalu... | IL-6/sIL-6R stimulation accelerated the ROR2/WNT5A pathway in hADSCs in a STAT3-dependent manner, resulting in augmented calcification. These results suggest that the mechanisms of ectopic calcification accelerated by IL-6 in hADSCs may be involved in chronic inflammatory tissues and that IL-6 inhibitors may be benefic... | yes |
24,599,913 | Is increased phosphorylation of ezrin associated with the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis? | {
"contexts": [
"Increasing evidence indicates that the cytoskeletal protein ezrin may play a critical role in cell motility. This study aims to investigate the role of ezrin in regulating the migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with RA.",
"Synovial tissues were obtaine... | Increased expression of p-ezrin may contribute to aberrant aggressive behaviours of RA FLSs, which are mediated by rho kinase and the p38 MAPK pathway. This suggests a novel strategy targeting phosphorylation of ezrin to prevent synovial invasiveness and joint destruction in RA. | yes |
24,590,657 | Are human bocaviruses commonly found in stools of hospitalized children without causal association to acute gastroenteritis? | {
"contexts": [
"Human bocaviruses (HBoVs) may be grouped into respiratory (HBoV1) and enteric (HBoV2-4) types. We examined this association of HBoV types and clinical symptoms in 955 children who had acute gastroenteritis (AGE, n = 172), acute respiratory tract infection (ARTI, n = 545) or symptoms of both (n = ... | HBoV2 and HBoV3 were more commonly found in stool than in nasal swab samples, but the findings could not be causally linked with AGE. HBoV1 was commonly found in stool samples during ARTI, with or without gastrointestinal symptoms. | yes |
24,592,925 | Does a novel microbiota stratification system predict future exacerbations in bronchiectasis? | {
"contexts": [
"Although airway microbiota composition correlates with clinical measures in non-cystic fibrosis bronchiectasis, these data are unlikely to provide useful prognostic information at the individual patient level. A system enabling microbiota data to be applied clinically would represent a substantia... | Stratification of patients with non-cystic fibrosis bronchiectasis on the basis of predominant bacterial taxa is more clinically informative than either conventional culture or quantitative PCR-based analysis. Further investigation is now required to assess the mechanistic basis of these associations. | yes |
24,592,927 | Does luteinizing hormone contribute to fetal tolerance by regulating adaptive immune responses? | {
"contexts": [
"Pregnancy hormones were proposed to be crucially involved in fetal tolerance. Recently, we showed that human chorionic gonadotropin (hCG) not only increases the number and activity of regulatory T cells (Treg) but also retains tolerogenic dendritic cells (DCs). Here, we investigate whether the hi... | Our data suggest that LH, similar to hCG, is involved in the regulation of adaptive immune responses, thus contributing to fetal tolerance. | yes |
24,613,982 | Do an update on supported employment for people with severe mental illness? | {
"contexts": [
"Individual Placement and Support (IPS) is an effective intervention for helping people with severe mental illness obtain competitive employment, yet it has not been widely implemented. This review will examine and summarize the latest research on IPS.",
"As the effectiveness of IPS has been w... | Although the field of research continues to expand, it is clear that many barriers remain to broad implementation of IPS. The solution goes beyond further research and involves policies and practices that support a recovery oriented mental healthcare system. | yes |
24,599,606 | Does p-glycoprotein promote epithelial T helper 2-associated cytokine secretion in chronic sinusitis with nasal polyps? | {
"contexts": [
"Sinonasal epithelial cells are recognized as drivers of inflammation in chronic sinusitis with nasal polyps (CRSwNP) through secretion of T helper 2 (Th2)-promoting cytokines. P-glycoprotein (P-gp) is overexpressed in nasal polyps and modulates epithelial cytokine secretion in healthy mucosa. The... | P-gp overactivity promotes Th2-associated epithelial cytokine secretion in nasal polyps, suggesting a novel mechanism for maintaining chronic inflammation in CRSwNP. | yes |
24,614,757 | Does arterial wall stress control NFAT5 activity in vascular smooth muscle cells? | {
"contexts": [
"Nuclear factor of activated T-cells 5 (NFAT5) has recently been described to control the phenotype of vascular smooth muscle cells (VSMCs). Although an increase in wall stress or stretch (eg, elicited by hypertension) is a prototypic determinant of VSMC activation, the impact of this biomechanica... | Collectively, our data suggest that biomechanical stretch is sufficient to activate NFAT5 both in native and cultured VSMCs where it regulates the expression of tenascin-C. This may contribute to an improved migratory activity of VSMCs and thus promote maladaptive vascular remodeling processes such as hypertension-indu... | yes |
24,609,797 | Do association between serum total antioxidant status and coronary microvascular function in idiopathic dilated cardiomyopathy? | {
"contexts": [
"Coronary microvascular impairment may cause myocardial ischemia and systolic dysfunction in patients with idiopathic dilated cardiomyopathy (IDC).",
"The study included 41 patients with IDC and 33 healthy control subjects. Serum total antioxidant status (TAS), serum interleukin (IL)-6 levels,... | Plasma proinflammatory cytokine levels are increased in patients with IDC. CFR was impaired as a reflection of impaired coronary microvascular dysfunction in association with increasing plasma proinflammatory cytokine levels and hsCRP levels. | yes |
24,602,327 | Are self-management abilities and frailty important for healthy aging among community-dwelling older people ; a cross-sectional study? | {
"contexts": [
"This study aimed to identify the relationships of self-management abilities and frailty to perceived poor health among community-dwelling older people in the Netherlands while controlling for important individual characteristics such as education, age, marital status, and gender.",
"The cross... | Self-management abilities and frailty are important for healthy aging among community-dwelling older people in the Netherlands. Particularly vulnerable are the lower educated older adults. Interventions to improve self-management abilities may help older people age healthfully and prevent losses as they age further. | yes |
24,608,794 | Do cYP2C19 polymorphisms and coronary heart disease risk factors synergistically impact clopidogrel response variety after percutaneous coronary intervention? | {
"contexts": [
"Platelet inhibition by clopidogrel is highly variable and the elevated platelet activity will increase the risk of major adverse cardiovascular events after percutaneous coronary intervention (PCI). CYP2C19 loss-of-function (LOF) alleles and risk factors of coronary heart disease (CAD) were repor... | Genetic CYP2C19 polymorphisms and CAD risk factors - type 2 diabetes mellitus and BMI - synergistically affect the antiplatelet activity of clopidogrel and the occurrence of major adverse cardiovascular events after PCI. | yes |
24,592,811 | Does z α1-antitrypsin confer a proinflammatory phenotype that contributes to chronic obstructive pulmonary disease? | {
"contexts": [
"Severe α1-antitrypsin deficiency caused by the Z variant (Glu342Lys; ZZ-AT) is a well-known genetic cause for emphysema. Although severe lack of antiproteinase protection is the critical etiologic factor for ZZ-AT-associated chronic obstructive pulmonary disease (COPD), some reports have suggeste... | We show here that aggregation of intracellular mutant Z-AT invokes a specific deleterious cellular inflammatory phenotype in COPD. Oxidant-induced intracellular polymerization of Z-AT in epithelial cells causes ER stress, and promotes excess cytokine and cellular inflammation. This pathway is likely to contribute to th... | yes |
24,591,530 | Is angiotensin-converting enzyme insertion/deletion gene polymorphism associated with dermatomyositis? | {
"contexts": [
"The cornerstone of dermatomyositis (DM) pathogenesis involves vascular disturbance that leads to hypoxia, capillary necrosis and muscle perifascicular atrophy. Hence, the hypothesis is that the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism could be associated with... | Homozygous ACE D/D was associated significantly with the DM risk. Further investigations are required to clarify and to confirm the association of these genes with DM susceptibility. | yes |
24,612,052 | Are coupling interval dispersion and body mass index independent predictors of idiopathic premature ventricular complex-induced cardiomyopathy? | {
"contexts": [
"Patients with frequent premature ventricular complexes (PVCs) might be at risk for the developing or exacerbation of left ventricular (LV) dysfunction. However, some patients with a high-PVC burden do not develop cardiomyopathy, while other patients with low-PVC burden can develop cardiomyopathy.... | In addition to the PVC burden, the CI-dispersion and BMI are associated with PVC-induced cardiomyopathy. | yes |
24,592,992 | Is high intratumoral macrophage content an adverse prognostic feature in anaplastic large cell lymphoma? | {
"contexts": [
"Macrophage infiltration has been associated with prognosis in several cancers, including lymphoma, but has not been assessed systematically in anaplastic large cell lymphoma (ALCL). The aim of the study was to correlate expression of the macrophage-associated antigens CD68 and CD163 with pre-ther... | A high content of intratumoral CD68- and/or CD163-positive macrophages correlates with an adverse outcome in ALK-negative ALCL. | yes |
24,591,149 | Do proteomic and genomic analyses suggest the association of apolipoprotein C1 with abdominal aortic aneurysm? | {
"contexts": [
"Abdominal aortic aneurysm (AAA) is an important cause of mortality in the elderly. Mouse models are widely used to investigate AAA pathogenesis but their suitability for biomarker discovery is unexplored.",
"We conducted a three-phase study. Phase 1: Aortas from angiotensin-II-infused apolipo... | ApoC1 may be a novel biomarker for AAA. | yes |
24,599,775 | Does frizzled10 mediate WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo? | {
"contexts": [
"WNT1 and WNT3A drive a dorsal to ventral gradient of β-catenin-dependent Wnt signaling in the developing spinal cord. However, the identity of the receptors mediating downstream functions remains poorly understood.",
"In this report, we show that the spatiotemporal expression patterns of FZD1... | Together, our results identify FZD10 as a receptor for WNT1 and WNT3A in the developing chick spinal cord. | yes |
24,606,596 | Are psychological but not vasomotor symptoms associated with temperament and character traits? | {
"contexts": [
"Recent evidence suggests that climacteric symptoms may be intensified by specific temperament and personality traits in postmenopausal women. In this study we investigate Cloninger's model of personality in relation to menopausal symptoms.",
"One-hundred and seventy peri- and postmenopausal w... | Our findings indicate that most temperament and character traits according to Cloninger's model in peri- and postmenopausal women varied significantly as compared to the general population. Among several traits, high Harm avoidance and low Self-directedness were most strongly associated with psychological climacteric d... | yes |
24,612,551 | Does treatment of ankylosing spondylitis with TNF inhibitors have adverse effect on results of liver function tests : a longitudinal study? | {
"contexts": [
"To retrospectively investigate and compare the effects of tumor necrosis factor alpha inhibitors (TNFi) on hepatic enzymes in ankylosing spondylitis (AS) patients.",
"A retrospective analysis of the records of 94 AS (66 male, 28 female) patients using TNFi was performed. Patients' clinical da... | TNFi use-associated rises in hepatic enzymes were determined compared to pre-treatment but the mean values remained within normal limits. Considering the cases in the literature, in daily practice patients must be carefully monitored for liver function before treatment and at follow-up. | no |
24,589,547 | Does repeated maternal intramuscular or intraamniotic erythromycin incompletely resolve intrauterine Ureaplasma parvum infection in a sheep model of pregnancy? | {
"contexts": [
"Ureaplasma spp are the most commonly isolated microorganisms in association with preterm birth. Maternal erythromycin administration is a standard treatment for preterm prelabor rupture of membranes. There is little evidence of its effectiveness in eradicating Ureaplasma spp from the intrauterine... | Erythromycin treatment, given both to the ewe and into the amniotic cavity, fails to eradicate intrauterine and fetal U parvum serovar 3 infection and may lead to development of erythromycin resistant U parvum. | yes |
24,601,781 | Are small acute increases in serum creatinine associated with decreased long-term survival in the critically ill? | {
"contexts": [
"Long-term outcomes after acute kidney injury (AKI) are poorly described.",
"We hypothesized that one single episode of minimal (stage 1) AKI is associated with reduced long-term survival compared with no AKI after recovery from critical illness.",
"A prospective cohort of 2,010 intensive ... | Patients with one episode of mild AKI have significantly lower long-term survival rates than critically ill patients with no AKI. Close medical follow-up of these patients may be warranted and mechanistic research is required to understand how AKI influences long-term events. | yes |
24,606,203 | Is tumour necrosis factor receptor superfamily member 9 ( TNFRSF9 ) up-regulated in reactive astrocytes in human gliomas? | {
"contexts": [
"The prognosis of patients with malignant gliomas is still dismal despite maximum treatment. Novel therapeutic alternatives targeting tumorigenic pathways are, therefore, demanded. In murine glioma models, targeting of tumour necrosis factor receptor superfamily (TNFRSF) 9 led to complete tumour e... | Our findings provide a novel, TNFRSF9-positive, reactive astrocytic phenotype and challenge the therapeutic suitability of TNFRSF9 as a promising target for human gliomas. | yes |
24,586,813 | Is low socioeconomic status associated with worse survival in children with cancer : a systematic review? | {
"contexts": [
"While low socioeconomic status (SES) has been associated with inferior cancer outcome among adults, its impact in pediatric oncology is unclear. Our objective was therefore to conduct a systematic review to determine the impact of SES upon outcome in children with cancer.",
"We searched Ovid ... | Socioeconomic gradients in which low SES is associated with inferior childhood cancer survival are ubiquitous in LMIC and common in HIC. Future studies should elucidate mechanisms underlying these gradients, allowing the design of interventions mediating socioeconomic effects. Targeting the effect of low SES will allow... | yes |
24,610,622 | Is the number of regular T cells and immature dendritic cells involved in mycosis fungoides linked to the tumor stage? | {
"contexts": [
"The balance between immune surveillance and immune escape determines the outcome of patients with primary mycosis fungoides (MF). FOXP3+ regulatory T cells (Tregs) and DC-SIGN+ immature dendritic cells (imDCs) play a central role in regulating the immune state in the progression of MF. However, w... | The predominant factor influencing the immune state is different for each MF stage. Therefore, therapeutic strategies that modulate the antitumor immune responses should be developed depending on MF progression. | yes |
24,613,195 | Is small vessel disease , but neither amyloid load nor metabolic deficit , dependent on age at onset in Alzheimer 's disease? | {
"contexts": [
"There is controversy concerning whether Alzheimer's disease (AD) with early onset is distinct from AD with late onset with regard to amyloid pathology and neuronal metabolic deficit. We hypothesized that compared with patients with early-onset AD, patients with late-onset AD have more comorbid sm... | Age at onset does not influence amyloid deposition or neuronal metabolic deficit in AD. The greater extent of SVD in late-onset AD influences the association between neuronal metabolic deficit and clinical symptoms. | yes |
24,588,943 | Does chronic prenatal stress epigenetically modify spinal cord BDNF expression to induce sex-specific visceral hypersensitivity in offspring? | {
"contexts": [
"Irritable bowel syndrome (IBS) is a heterogeneous disorder with abdominal pain as one of the primary symptoms. The etiology of IBS remains unknown. Epidemiological studies found that a subset of these patients have a history of adverse early-life experiences. We tested the hypothesis that chronic... | The development of VHS, which contributes to the symptom of intermittent abdominal pain, is a two-step process, chronic in utero stress followed by chronic stress in adult-life. This two-step process induces aggravated and persistent colon hypersensitivity in female than in male offspring. Our preclinical model explain... | yes |
24,604,557 | Is incidental dose to coronary arteries higher in prone than in supine whole breast irradiation . A dosimetric comparison in adjuvant radiotherapy of early stage breast cancer? | {
"contexts": [
"Sparing of normal lung is best achieved in prone whole breast irradiation (WBI). However, exposure of the heart and coronary arteries might increase due to anterior movement of the heart in prone WBI.",
"Treatment plans of 46 patients with large breasts irradiated for mammary cancer after bre... | The heart dose is not different between supine and prone WBI. However, in left WBI the incidental dose to the LAD with clinically relevant doses can be significantly higher in prone WBI. This is discussed controversially in the literature as it might depend on contouring and treatment techniques. We recommend contourin... | yes |
24,595,150 | Are fatty liver and serum cholinesterase independently correlated with HbA1c levels : cross-sectional analysis of 5384 people? | {
"contexts": [
"To examine the association between glycosylated haemoglobin (HbA1c) and fatty liver markers.",
"This cross-sectional analysis stratified subjects into quintiles based on HbA1c. Fatty liver using ultrasonography scores (FLUS) were assigned as follows: 2 points, moderate or severe fatty liver; ... | The findings show that both ChE and FLUS are significantly correlated with HbA1c, independent of BMI and age. | yes |
24,600,981 | Are all eotaxins CCL11 , CCL24 and CCL26 increased but to various extents in pulmonary tuberculosis patients? | {
"contexts": [
"Mycobacterium tuberculosis is a pulmonary pathogen responsible for tuberculosis. Tuberculosis (TB) is characterized histologically by granulomas at the site of disease activity. Primary pathologic feature of TB is formation of a granuloma, and chemokines are known to play an important role in the... | According to the present results it can be concluded that CCL11, CCL24, and CCL26 (which are produced by Th2 cells and other cells which induce Th2 development) are increased in TB patients; hence, it seems that TB suppresses Th1 and the classic function of macrophages subsequently by inducing the chemokines' expressio... | yes |
24,584,063 | Are perioperative levels and changes of high-sensitivity troponin T associated with cardiovascular events in vascular surgery patients? | {
"contexts": [
"Myocardial infarction after major surgery is frequent, drives outcome, and consumes health resources. Specific prediction and detection of perioperative myocardial infarction is an unmet clinical need. With the widespread use of high-sensitive cardiac troponin T assays, positive tests become freq... | The risk predictive power of high-sensitive cardiac troponin T change in addition to the Revised Cardiac Risk Index could facilitate 1) detection of patients at highest risk for perioperative myocardial ischemia, 2) evaluation and development of cardioprotective therapeutic strategies, and 3) decisions for admission to... | yes |
24,590,006 | Is increased slope of the lateral tibial plateau subchondral bone associated with greater risk of noncontact ACL injury in females but not in males : a prospective cohort study with a nested , matched case-control analysis? | {
"contexts": [
"There is an emerging consensus that increased posterior-inferior directed slope of the subchondral bone portion of the tibial plateau is associated with increased risk of suffering an anterior cruciate ligament (ACL) injury; however, most of what is known about this relationship has come from unm... | There is a 21.7% increased risk of noncontact ACL injury with each degree increase of the lateral tibial plateau slope among females but not among males. The medial tibial plateau slope, coronal tibial slope, and depth of the medial tibial plateau were not associated with risk of injury for females or males. | yes |
24,602,098 | Do the association of early-life and substance use risks to violent offending among injecting drug users? | {
"contexts": [
"It remains unclear whether violent offending among injecting drug users (IDU) is the direct result of drug use factors or whether they are predisposed to violent behaviour from childhood. The current study sought to identify substance use and early-life correlates of lifetime violent offending am... | Drug use factors alone did not adequately explain the likelihood of violent offending among IDUs. Instead, there appeared to be complex interactions between early-life risks and substance use which created a liability to violent offending, and the level of exposure to these risks appeared to explain differences in viol... | yes |
24,612,089 | Does miR-494 act as an anti-oncogene in gastric carcinoma by targeting c-myc? | {
"contexts": [
"We recently showed that miR-494 was downregulated in gastric carcinoma (GC). The objectives of this study were to determine the role of miR-494 in GC malignancy and to identify its target genes.",
"Real-time polymerase chain reaction was employed to quantify the expression level of miR-494 an... | miR-494 is downregulated in human GC and acts as an anti-oncogene by targeting c-myc. miR-494 plays a role in the pathogenesis of gastric cancer in a recessive fashion. | yes |
24,595,055 | Is casein kinase II induced polymerization of soluble TDP-43 into filaments inhibited by heat shock proteins? | {
"contexts": [
"Trans-activation Response DNA-binding Protein-43 (TDP-43) lesions are observed in Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Lobar Degeneration with ubiquitin inclusions (FTLD-TDP) and 25-50% of Alzheimer's Disease (AD) cases. These abnormal protein inclusions are composed of either amor... | These findings demonstrate CKII induces polymerization of soluble TDP-43 into filaments and Hsp90 promotes TDP-43 filament depolymerization. These findings provide rational for potential therapeutic intervention at these points in TDP-43 proteinopathies. | yes |
24,595,866 | Is exposure to parental smoking in childhood or adolescence associated with increased carotid intima-media thickness in young adults : evidence from the Cardiovascular Risk in Young Finns study and the Childhood Determinants of Adult Health Study? | {
"contexts": [
"Recent evidence suggests that the exposure of children to their parents' smoking adversely effects endothelial function in adulthood. We investigated whether the association was also present with carotid intima-media thickness (IMT) up to 25 years later.",
"The study comprised participants fr... | These results show the pervasive effect of exposure to parental smoking on children's vascular health up to 25 years later. There must be continued efforts to reduce smoking among adults to protect young people and to reduce the burden of cardiovascular disease across the population. | yes |
24,602,119 | Does disease duration determine health-related quality of life in adult eosinophilic esophagitis patients? | {
"contexts": [
"Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by relapsing symptoms of dysphagia. The quality of life (QoL) of EoE patients is impaired, but risk factors for impaired QoL have not been identified. The chronic nature of the disease, requiring multi... | The QoL is particularly impaired in young adult EoE patients. Disease duration determines the mental QoL. This study offers additional insight into the impact of EoE on patients' lives and emphasizes the importance of early diagnosing and adequately treating EoE. | yes |
24,597,399 | Does patient gender affect outcome after transcatheter aortic valve implantation ( TAVI )? | {
"contexts": [
"Female gender has recently been suggested to predict a beneficial outcome and lower mortality following transcatheter aortic valve implantation (TAVI). The study aim was to address gender differences in outcome following TAVI and potentially to replicate these findings.",
"The present single-... | While several baseline characteristics between men and women treated by TAVI were shown to be different among the study population, no difference was observed in survival between both genders. | no |
24,591,842 | Is cyclooxygenase-2 inhibitor a robust enhancer of anticancer agents against hepatocellular carcinoma multicellular spheroids? | {
"contexts": [
"Celecoxib, an inhibitor of cyclooxygenase-2 (COX2), was investigated for enhancement of chemotherapeutic efficacy in cancer clinical trials. This study aimed to determine whether celecoxib combined with 5-fluorouracil or sorafenib or gefitinib is beneficial in HepG2 multicellular spheroids (MCSs)... | Celecoxib combined with 5-fluorouracil or sorafenib or gefitinib may be superior to single-agent therapy in HepG2 MCSs. Our results provided molecular evidence to support celecoxib combination-treatment strategies for patients with human hepatocellular carcinoma. MCSs provided a good model to evaluate the interaction o... | yes |
24,591,841 | Is aBCC4 required for cell proliferation and tumorigenesis in non-small cell lung cancer? | {
"contexts": [
"Multidrug resistance protein 4 (MRP4), also known as ATP-cassette binding protein 4 (ABCC4), is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, which are capable of pumping a wide variety of drugs out of the cell. However, little is known about the function of ABCC4 in th... | ABCC4 may play an important role in the control of A549 and 801D cell growth. ABCC4 is a potential target for lung cancer therapy. | yes |
24,594,092 | Is level of consciousness on admission to a Heart Attack Centre a predictor of survival from out-of-hospital cardiac arrest? | {
"contexts": [
"The relationship between the neurological status at the time of handover from the ambulance crew to a Heart Attack Centre (HAC) in patients who have achieved return of spontaneous circulation (ROSC) and subsequent outcome, in the context of current treatment standards, is unknown.",
"A retros... | Patients with shockable rhythms achieving ROSC are more likely to be conscious (A or V) compared with those with non-shockable rhythms. Most patients who are conscious on admission to the HAC will survive, compared with approximately half of those who are unconscious (P or U), suggesting that critical care is generally... | yes |
24,612,278 | Is fatigue highly associated with poor health-related quality of life , disability and depression in newly-diagnosed patients with inflammatory bowel disease , independent of disease activity? | {
"contexts": [
"Fatigue is common in Crohn's disease (CD) and ulcerative colitis (UC). Data on fatigue in newly diagnosed patients are unavailable.",
"To report prevalence of fatigue in newly diagnosed CD and UC patients and examine its association with health-related quality of life (HRQOL), depression and ... | Fatigue is strongly associated with poor HRQOL, disability and depression similarly in CD and UC even when controlling for disease activity. Fatigue's association with a wide range of patient-reported outcome measures suggests that monitoring fatigue is a simple way to screen for overall disruption in patient life. | yes |
24,593,947 | Does artificial neural network predict the need for therapeutic ERCP in patients with suspected choledocholithiasis? | {
"contexts": [
"Selection of patients with the highest probability for therapeutic ERCP remains an important task in a clinical workup of patients with suspected choledocholithiasis (CDL).",
"To determine whether an artificial neural network (ANN) model can improve the accuracy of selecting patients with a h... | Only those variables believed to be related to the outcome of interest were included. The majority of patients in our sample had positive findings on ERCP. | yes |
24,599,410 | Is nrf2 useful for predicting the effect of chemoradiation therapy on esophageal squamous cell carcinoma? | {
"contexts": [
"The transcription factor NF-E2-related factor 2 (Nrf2) was originally identified to be a critical regulator of intracellular antioxidants and phase II detoxification enzymes. Recent studies have shown that high Nrf2 expression gives cancer cells an advantage for survival from anticancer chemother... | Nrf2 expression was found to be closely related to the effect of CRT and could predict the CRT outcome in patients with ESCC. | yes |
24,611,993 | Do alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats? | {
"contexts": [
"Corticotropin-releasing hormone (CRH) and urocortins (UCNs) bind to corticotropin-releasing hormone type 2 receptor (CRF2 receptor ), a Gs protein-coupled receptor that plays an important role in modulation of anxiety and stress responses. The Crhr2 gene maps to a quantitative trait locus (QTL) f... | This study identified Crhr2 as a candidate gene of interest underlying the chromosome 4 QTL for alcohol consumption that was previously identified in the P and NP model. Crhr2 promoter polymorphism is associated with reduced mRNA expression in certain brain regions, particularly the amygdala, and lowered the density of... | yes |
24,604,352 | Does inhibiting mast cell degranulation by HO-1 affect dendritic cell maturation in vitro? | {
"contexts": [
"Mast cell (MC) degranulation can break peripheral immune tolerance. However, its mechanism remains unclear. Our goal was to study the stabilization of MC membranes by heme oxygenase-1 (HO-1) in order to influence dendritic cell (DC) function.",
"Mast cells and dendritic cells were prepared fr... | Inhibiting MC degranulation by HO-1 restrained DC maturation and attenuated the proliferation of SMCs. | yes |
24,609,059 | Does mitochondrial dysfunction promote and aggravates the inflammatory response in normal human synoviocytes? | {
"contexts": [
"In RA, synoviocytes cause increased oxidative stress, leading to mitochondrial alterations that may participate in the pathogenesis of RA. Here we investigated whether mitochondrial dysfunction induces inflammatory responses in cultured normal human synoviocytes, a hallmark of RA.",
"Mitochon... | These data suggest that mitochondrial dysfunction could induce an inflammatory response in normal human synoviocytes and sensitize these cells, causing a significant amplification of the inflammatory response induced by IL-1β. Resveratrol may represent a promising strategy in controlling the synovial inflammatory respo... | yes |
24,606,633 | Is tGFβR2 a major target of miR-93 in nasopharyngeal carcinoma aggressiveness? | {
"contexts": [
"MiR-17-92 cluster and its paralogues have emerged as crucial regulators of many oncogenes and tumor suppressors. Transforming growth factor-β receptor II (TGFβR2), as an important tumor suppressor, is involved in various cancer types. However, it is in cancer that only two miRNAs of this cluster ... | The present study reports an involvement of miR-93-mediated TGFβR2 down-regulation in NPC aggressiveness, thus giving extended insights into molecular mechanisms underlying cancer aggressiveness. Approaches aimed at blocking miR-93 may serve as a promising therapeutic strategy for treating NPC patients. | yes |
24,606,639 | Does myo-inositol modulate insulin and luteinizing hormone secretion in normal weight patients with polycystic ovary syndrome? | {
"contexts": [
"To investigate hormonal dynamics in a group of non-obese polycystic ovary syndrome (PCOS) patients under myo-inositol (MYO) administration.",
"Hormonal profiles, insulin response to oral glucose tolerance test (OGTT) and luteinizing hormone (LH) response to gonadotropin-releasing hormone (GnR... | MYO administration positively modulates insulin sensitivity in non-obese PCOS patients without compensatory hyperinsulinemia, improving hormonal parameters. The presence of bromelin in the formulation modulated the pro-inflammatory state that characterizes PCOS, independently of BMI. | yes |
24,607,304 | Do rice bran enzymatic extract-supplemented diets modulate adipose tissue inflammation markers in Zucker rats? | {
"contexts": [
"Chronic low-grade inflammation in obesity is characterized by macrophage accumulation in white adipose tissue and adipokine production deregulation. Obesity also is characterized by oxidative stress related to inflammatory signaling. The aim of this study was to analyze whether dietary supplement... | Chronic administration of a novel water-soluble RBEE, rich in polyphenols, tocotrienols and γ-oryzanol, could be a suitable treatment to ameliorate the obesity-associated proinflammatory response. | yes |
24,607,303 | Does brazilian nut consumption by healthy volunteers improve inflammatory parameters? | {
"contexts": [
"The aim of this study was to investigate the effect of a single dose of Brazil nuts on the inflammatory markers of healthy individuals.",
"A randomized crossover study was conducted with 10 healthy individuals (mean age 24.7 ± 3.4 y). Each individual was tested four times regarding intake of ... | The results indicate a long-term decrease in inflammatory markers after a single intake of large portions of Brazil nuts in healthy volunteers. Therefore, the long-term effect of regular Brazil nut consumption on inflammatory markers should be better investigated. | yes |
24,602,473 | Do transgenerational effects of maternal care interact with fetal growth and influence attention skills at 18 months of age? | {
"contexts": [
"Evidence suggests that there is an association between being born small for gestational age (SGA) and an increased risk of internalizing and externalizing problems, such as ADHD. Additionally, individuals who report having received a lower quality of maternal care show an increased prevalence of ... | These findings suggest a complex transgenerational transmission whereby mother's own care interacts with the fetal growth of her offspring to predict its attentional skills at 18 months of age. | yes |
24,593,254 | Does pharmacological inhibition of poly ( ADP-ribose ) polymerase-1 modulate resistance of human glioblastoma stem cells to temozolomide? | {
"contexts": [
"Chemoresistance of glioblastoma multiforme (GBM) has been attributed to the presence within the tumor of cancer stem cells (GSCs). The standard therapy for GBM consists of surgery followed by radiotherapy and the chemotherapeutic agent temozolomide (TMZ). However, TMZ efficacy is limited by O6-me... | The combination of TMZ with PARPi may represent a valuable strategy to reverse GSC chemoresistance. | yes |
24,593,251 | Does 12/15-Lipoxygenase deficiency reduce densities of mesenchymal stem cells in the dermis of wounded and unwounded skin? | {
"contexts": [
"Mesenchymal stem cells (MSCs) promote skin healing. 12/15-Lipoxgenase (LOX) is crucial in producing specific lipid mediators in wounded skin. The consequences of 12/15-LOX deficiency in MSC densities in skin are unknown.",
"To determine the effect of 12/15-LOX deficiency in MSC densities in w... | 12/15-LOX deficiency reduces MSC densities in the dermis, which correlates with the suppressed 12/15-LOX pathways in wounded and unwounded skin. | yes |
24,590,434 | Are postgastrectomy Syndrome Assessment Scale ( PGSAS ) -45 and changes in body weight useful tools for evaluation of reconstruction methods following distal gastrectomy? | {
"contexts": [
"Billroth-I (BI) and Roux-en-Y (RY) are well-known reconstruction methods that are conducted following distal gastrectomy. However, the relative merits of these 2 methods are not well documented. The newly developed Postgastrectomy Syndrome Assessment Scale (PGSAS)-45 is an integrated questionnair... | Although weight loss was significantly lower following BI procedures, esophageal reflux symptoms were significantly higher. Either BI or RY procedures may be recommended based on the individual patient's condition after distal gastrectomy. The newly developed QOL questionnaire, PGSAS-45 and changes in body weight prove... | yes |
24,612,304 | Does protease-modulating polyacrylate-based hydrogel stimulate wound bed preparation in venous leg ulcers -- a randomized controlled trial? | {
"contexts": [
"Stringent control of proteolytic activity represents a major therapeutic approach for wound-bed preparation.",
"We tested whether a protease-modulating polyacrylate- (PA-) containing hydrogel resulted in a more efficient wound-bed preparation of venous leg ulcers when compared to an amorphous... | In particular, long-standing wounds profited from the treatment with the PA-based hydrogel. These data suggest that PA-based hydrogel dressings can stimulate normalization of the wound environment, particularly in hard-to-heal ulcers. | yes |
24,607,493 | Does immunohistochemical analysis of molecular drivers in melanoma identify p16 as an independent prognostic biomarker? | {
"contexts": [
"To perform immunohistochemical (IHC) analysis of molecular drivers related to the development and maintenance of melanoma and to assess their value as diagnostic and prognostic melanoma biomarkers in routine clinical practice.",
"Tissue microarrays constructed from a cohort of primary melanom... | IHC determined p16 expression is an independent prognostic biomarker of potential value in routine melanoma diagnostic practice. | yes |
24,603,597 | Does a novel three serum phospholipid panel differentiate normal individuals from those with prostate cancer? | {
"contexts": [
"The results of prostate specific antigen (PSA) and digital rectal examination (DRE) screenings lead to both under and over treatment of prostate cancer (PCa). As such, there is an urgent need for the identification and evaluation of new markers for early diagnosis and disease prognosis. Studies h... | In summary, we have demonstrated that ePC 38:5, PC 40:3, and PC 42:4 may serve as early predictive serum markers for the presence of PCa. | yes |
24,603,415 | Is high intraocular pressure associated with cardiometabolic risk factors in South Korean men : Korean National Health and Nutrition Examination Survey , 2008-2010? | {
"contexts": [
"Elevated intraocular pressure (IOP) contributes to the progression of visual defects such as glaucoma. This study determined whether metabolic syndrome (MetS) and cardiovascular risk factors are associated with IOP in South Korean men.",
"We analyzed data on 4875 men who participated in the K... | Cardiometabolic risk factors, including the components of MetS, are associated with increased IOP. | yes |
24,615,418 | Does standardized cine-loop documentation in renal ultrasound facilitate skill-mix between radiographer and radiologist? | {
"contexts": [
"The radiographers' role in ultrasound (US) has been debated due to the operator-dependent aspect of diagnostic US. With standardized cine-loop ultrasound (SCUS) a reliable diagnosis can be achieved by reading SCUS independently from performing the procedure.",
"To study the correlation betwee... | There is a high degree of correlation between reported findings in radiologist and radiographer performed SCUS examinations. | yes |
24,588,456 | Is ultrasonography-guided radial artery catheterization superior compared with the traditional palpation technique : a prospective , randomized , blinded , crossover study? | {
"contexts": [
"Radial artery catheterization is gaining popularity for diagnostic and interventional procedures. Palpation technique is widely used for the procedure, but ultrasonography has been shown to increase catheterization success. A recently described ultrasonography technique is termed 'dynamic needle ... | Ultrasonography guidance using the dynamic needle tip positioning technique for radial artery catheterization significantly improves clinically relevant aspects of the procedure. | yes |
24,590,328 | Are socioeconomic factors associated with frequency of repeat emergency department visits for pediatric closed fractures? | {
"contexts": [
"Previous research has demonstrated both greater difficulty in obtaining follow-up appointments and increased likelihood of return visits to the emergency department (ED) for patients with government-funded insurance plans. The purpose of the current study is to determine whether socioeconomic fac... | Our analysis revealed that nonwhite patients are more likely to return to the ED within 8 weeks for the same fracture diagnosis. Patients with government insurance are 55% more likely to have a revisit, whereas patients with private insurance are 28% less likely to have a revisit. Our results suggest that socioeconomic... | yes |
24,603,284 | Are multisite pain , pain frequency and pain severity associated with depression in older adults : results from the ActiFE Ulm study? | {
"contexts": [
"there is ample literature showing pain and depression are related. However, different dimensions of pain have been used in former studies.",
"the objective of the study was to compare the strength of the association of different pain dimensions with depression in older adults.",
"assessme... | multisite pain, pain severity and frequency were the best predictors of late life depression. Clinicians should be especially aware of depressive disorders when older patients are complaining of pain in multiple areas across the body. | yes |
24,591,755 | Is kE and EE genotypes of ICAM-1 gene K469E polymorphism associated with severe preeclampsia? | {
"contexts": [
"Preeclampsia (PE) is one of the most important complications of pregnancy that is associated with significant mortality and morbidity in mother and fetus. Since the etiologic factors in its development are still unclear, we aimed to examine the intercellular adhesion molecule-1 (ICAM-1) gene K469... | We concluded that KE and EE genotypes of K469E polymorphism could increase risk of severe PE. | yes |
24,603,562 | Does early enteral fat supplementation improve protein absorption in premature infants with an enterostomy? | {
"contexts": [
"Early enteral fat supplementation and fish oil (FO) stimulates post-resection intestinal adaptation in rats and increases fat absorption in premature infants with bowel resection and an enterostomy.",
"To test the hypothesis that early fat supplement and FO increases post-resection protein ab... | Early supplementation of enteral ML and FO to premature infants with an enterostomy increased dietary protein absorption, intestinal RNA, protein and n-3 EPA content without altering other FA content. | yes |
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