pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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24,608,309 | Is autonomic rectal dysfunction in patients with multiple sclerosis and bowel symptoms secondary to spinal cord disease? | {
"contexts": [
"Most patients with multiple sclerosis report bowel symptoms, but the underlying pathophysiology is unclear.",
"We hypothesize that rectal dysfunction in multiple sclerosis is secondary to involvement of the spinal cord by the disease and that this can be measured by assessing rectal complianc... | Limitations to this study include the lack of an asymptomatic group with multiple sclerosis and the small sample size to evaluate bowel symptoms. | yes |
24,602,014 | Does collagen remodeling and peripheral immune cell recruitment characterize the cutaneous Langerhans cell histiocytosis microenvironment? | {
"contexts": [
"Langerhans cell histiocytosis (LCH) is a rare and potentially fatal disorder of unknown etiology arising from the accumulation of epidermal Langerhans-like cells in bone, skin, or other tissues. Tissue damage and morbidity results from lesional cytokine release, and we sought to investigate the L... | Cutaneous LCH lesions are associated with the peripheral recruitment of a variety of immune cells and are consistently characterized by localized elastosis, collagen damage, and remodeling. | yes |
24,593,837 | Is congenital cytomegalovirus infection associated with high maternal socio-economic status and corresponding low maternal cytomegalovirus seropositivity? | {
"contexts": [
"Human cytomegalovirus (CMV) is the leading infectious cause of congenital infection in developed countries. Globally, CMV seropositivity has been associated with low socio-economic status (SES); however, Australian data are lacking. Therefore, we examined the association between SES and CMV serop... | A marked socio-economic gradient in CMV seroprevalence is evident in Australian pregnant women and cases of congenital CMV but not in unselected Australian children. These findings highlight the importance of a community-wide approach to CMV awareness and the potential for hygienic measures to reduce the burden of cong... | yes |
24,604,365 | Is misdiagnosis of hemifacial spasm a frequent event in the primary care setting? | {
"contexts": [
"Primary hemifacial spasm (HFS) is characterized by irregular and involuntary contraction of the muscles innervated by the ipsilateral facial nerve. Treatment controls symptoms and improves quality of life (QoL).",
"Evaluate the initial diagnosis and treatment of HFS prior to referral to a ter... | Despite its relatively straightforward diagnosis, all patients had an incorrect diagnosis and treatment on their first evaluation. HFS brings social impairment and the delay in adequate treatment negatively impacts QoL. | yes |
24,606,425 | Does down-regulation of phosphoglucose isomerase/autocrine motility factor enhance gensenoside Rh2 pharmacological action on leukemia KG1α cells? | {
"contexts": [
"Ginsenoside Rh2, which exerts the potent anticancer action both in vitro and in vivo, is one of the most well characterized ginsenosides extracted from ginseng. Although its effects on cancer are significant, the underlying mechanisms remain unknown. In this study, we sought to elucidate possible... | These results suggested that ginsenoside Rh2 suppressed the proliferation of KG1α, the same as down-regulation of PGI/AMF. Down-regulation of PGI/ AMF enhanced the pharmacological effects of ginsenoside Rh2 on KG1α by reducing Akt/mTOR signaling. | yes |
24,586,232 | Is communicating hydrocephalus following eosinophilic meningitis pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia? | {
"contexts": [
"Viliuisk encephalomyelitis (VE) is an endemic neurological disease in Northeast Siberia and generally considered to be a chronic encephalomyelitis of unknown origin actually spreading in the Sakha (Yakutian) Republic.",
"In search for the pathophysiology and causative agent of VE, we performe... | Our data showed that pressure by the communicating hydrocephalus as a mechanical factor is the major pathogenic mechanism in chronic VE, most likely triggered by eosinophilic meningitis. There are no signs for an ongoing inflammatory process in chronic VE. The past eosinophilic reaction in VE might be caused by Toxocar... | yes |
24,586,238 | Does prostaglandin E2 reduce the release and infectivity of new cell-free virions and cell-to-cell HIV-1 transfer? | {
"contexts": [
"The course of human immunodeficiency virus type-1 (HIV-1) infection is influenced by a complex interplay between viral and host factors. HIV infection stimulates several proinflammatory genes, such as cyclooxigense-2 (COX-2), which leads to an increase in prostaglandin (PG) levels in the plasma o... | Our results demonstrate that PGE2, through Epac and Rap activation, alters the transport of newly synthesized HIV-1 components to the assembly site, reducing the release and infectivity of new cell-free virions and cell-to-cell HIV-1 transfer. | yes |
24,598,712 | Are pathogenic variants in TUBB4A found in primary dystonia? | {
"contexts": [
"To determine the contribution of TUBB4A, recently associated with DYT4 dystonia in a pedigree with \"whispering dysphonia\" from Norfolk, United Kingdom, to the etiopathogenesis of primary dystonia.",
"High-resolution melting and Sanger sequencing were used to inspect the entire coding region... | The c.4C>G DYT4 mutation appears to be private, and clinical testing for TUBB4A mutations is not justified in spasmodic dysphonia or other forms of primary dystonia. Moreover, given its allelic association with leukoencephalopathy hypomyelination with atrophy of basal ganglia and cerebellum and protean clinical manifes... | no |
24,595,249 | Does intrathecal injection of human umbilical cord blood stem cells attenuate spinal cord ischaemic compromise in rats? | {
"contexts": [
"Spinal cord ischaemia with resulting paraplegia remains a devastating and unpredictable complication after thoraco-abdominal aortic surgery. With the advent of stem cell therapy and its potential to induce nervous tissue regeneration processes, the interest in the use of these cells as a treatmen... | Intrathecal transplantation of HUCBSCs is feasible, and it improved spinal cord function, when they were delivered 30 min after spinal cord ischaemia, in a model of endovascular descending thoracic aorta occlusion in rats. Human umbilical cord blood is one of the potentially useful sources of stem cells for therapy of ... | yes |
24,592,878 | Do bacillus Calmette-Guérin and isoniazid preventive therapy protect contacts of patients with tuberculosis? | {
"contexts": [
"Individuals living with patients with tuberculosis (TB) are at elevated risk of infection and disease, with children at greatest risk. The World Health Organization recommends isoniazid preventive therapy (IPT) for HIV-positive contacts and those younger than 5 years. Despite these recommendation... | These findings support the use of IPT in older children and young-adult household contacts, in addition to children younger than 5 years. | yes |
24,602,188 | Are heterogeneous atypical cell populations present in blood of metastatic breast cancer patients? | {
"contexts": [
"Circulating tumor cells (CTCs) are commonly isolated from the blood by targeting the epithelial cell adhesion molecule (EpCAM) through positive selection. However, EpCAM can be downregulated during metastatic progression, or it can be initially not present. We designed the present prospective tri... | Metastatic breast cancer patients have atypical cells that are CK + EpCAM - circulating in their blood. Because a substantial number of these patients do not have EpCAM + CTCs, additional studies are needed to evaluate the role of EpCAM - circulating cells as a prognostic and predictive marker. | yes |
24,606,172 | Is cystatin C differentially involved in multiple system atrophy phenotypes? | {
"contexts": [
"As cystatin C (CysC) is involved in some forms of neurodegeneration, we investigated the possible relationship between CysC and multiple system atrophy (MSA), including its parkinsonian (MSAp) and cerebellar (MSAc) phenotypes.",
"Cystatin C gene (CST3) haplotypes were determined by PCR follow... | CysC changes are differentially present in the parkinsonian and cerebellar forms of MSA and may play an important role in the pathogenesis of this neurodegenerative condition. | yes |
24,612,901 | Do computerized self-interviews improve Chlamydia and gonorrhea testing among youth in the emergency department? | {
"contexts": [
"National guidelines recommend annual Chlamydia trachomatis and Neisseria gonorrhoeae screening for sexually active youth at risk for infection. These infections have serious sequelae in women if untreated, and methods to improve testing are needed. We hypothesize that an electronic method of iden... | Sexually transmitted infection testing in the ED significantly increased during ACASI use and diminished after withdrawal. The ACASI was well accepted by youth and holds promise for enhancing sexually transmitted infection testing in the ED. | yes |
24,601,936 | Is visceral adiposity index ( VAI ) related to the severity of anovulation and other clinical features in women with polycystic ovary syndrome? | {
"contexts": [
"The clinical phenotype of polycystic ovary syndrome (PCOS) includes reproductive and hormonal aberrations. Visceral adiposity index (VAI) is an indicator which could connect hyperandrogenism and anovulation. The objective was to evaluate the relationship between VAI, menstrual disorders and hormo... | Visceral adiposity index is increased in patients with PCOS in concordance with the severity of anovulation, insulin resistance and inflammation. This index could be a very easy and helpful clinical tool in daily practice to predict insulin resistance in women with PCOS. | yes |
24,606,812 | Is presence of intratumoral platelets associated with tumor vessel structure and metastasis? | {
"contexts": [
"Platelets play a fundamental role in maintaining hemostasis and have been shown to participate in hematogenous dissemination of tumor cells. Abundant platelets were detected in the tumor microenvironment outside of the blood vessel, thus, platelet -tumor cell interaction outside of the bloodstrea... | Our findings demonstrate that platelets within the primary tumor microenvironment play a critical role in the induction of vascular permeability and initiation of tumor metastasis. | yes |
24,610,330 | Does pREPL deficiency with or without cystinuria cause a novel myasthenic syndrome? | {
"contexts": [
"To investigate the genetic and physiologic basis of the neuromuscular symptoms of hypotonia-cystinuria syndrome (HCS) and isolated PREPL deficiency, and their response to therapy.",
"We performed molecular genetic, histochemical, immunoblot, and ultrastructural studies, investigated neuromusc... | Isolated PREPL deficiency is a novel monogenic disorder that causes a congenital myasthenic syndrome with pre- and postsynaptic features and growth hormone deficiency. The myasthenic symptoms in PREPL deficiency with or without cystinuria may respond to pyridostigmine in early life. We attribute the myasthenia to abrog... | yes |
24,587,954 | Does receptor Interacting Protein 2 ( RIP2 ) be Dispensable for OVA-Induced Airway Inflammation in Mice? | {
"contexts": [
"Asthma is a pulmonary chronic inflammatory disease characterized by airway obstruction and hyperresponsiveness. Pattern recognition receptors are known to play a key role in the development of allergic diseases as well as host defenses against microbial infection. Receptor interacting protein 2 (... | Our results suggest that RIP2 is not associated with the development of allergic airway inflammation. | yes |
24,587,951 | Do polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics? | {
"contexts": [
"Endoplasmic reticulum (ER) stress has recently been observed to activate NF-kappaB and induce inflammatory responses such as asthma. Activating transcription factor 6β (ATF6B) is known to regulate ATFα-mediated ER stress response. The aim of this study is to investigate the associations of ATF6B ... | Although further functional and replication studies are needed, our preliminary findings suggest that ATF6B may be related to obstructive phenotypes in response to aspirin exposure in adult asthmatics. | yes |
24,591,998 | Is second trimester serum alpha-fetoprotein level a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum? | {
"contexts": [
"The aim of this study was to determine the association between three parameters of second trimester serum secreening and preterm labor and intrauterine growth restriction (IUGR) in patients with hyperemesis gravidarum (HG).",
"A prospective study on 429 pregnancies with HG was designed to det... | Our study suggests that AFP levels of the second trimester screening test higher than 1.55 MoM is significantly associated with IUGR in hyperemesis gravidarum. The second trimester screening test can predict poor outcome in HG. | yes |
24,612,649 | Are insulin levels and HOMA index associated with exercise capacity in patients with type 2 diabetes and coronary artery disease? | {
"contexts": [
"Previous studies on type 2 diabetes have shown an association between exercise capacity and insulin resistance. In patients with coronary artery disease (CAD) exercise capacity is often reduced due to exercise-induced ischemia. We have investigated the association between glucometabolic control, ... | Insulin resistance, as estimated by fasting insulin and the HOMA index, was inversely associated with exercise capacity in patients with type 2 diabetes and CAD, the association being more pronounced in the subgroup with exercise-induced ischemia. These results indicate that insulin resistance is related to exercise ca... | yes |
24,595,587 | Are early-onset seizures correlated with late-onset seizures in children with arterial ischemic stroke? | {
"contexts": [
"Early-onset seizures are common in children with arterial ischemic stroke, but the clinical features and effects on the outcome of early-onset seizures have been less studied in children.",
"Children aged 1 month to 18 years presenting with first-time and image-confirmed arterial ischemic str... | Early-onset seizures occurred in 25.6% of children with arterial ischemic stroke. Younger age and cortical involvement were risk factors for early-onset seizures. Sixty-five percent of children with early-onset seizures had late-onset seizures after the acute stage. | yes |
24,608,675 | Does palmitic acid induce autophagy in hepatocytes via JNK2 activation? | {
"contexts": [
"Free fatty acid-induced lipotoxicity plays a crucial role in the progression of nonalcoholic fatty liver disease (NAFLD). In the present study we investigated the effects of a high-fat diet and free fatty acids on the autophagic process in hepatocytes in vivo and in vitro and the underlying mecha... | JNK1 promotes PA-induced lipoapoptosis, whereas JNK2 activates pro-survival autophagy and inhibits PA lipotoxicity. Our results suggest that modulation of autophagy may have therapeutic benefits in the treatment of lipid-related metabolic diseases. | yes |
24,608,674 | Does icaritin suppress the proliferation of human osteosarcoma cells in vitro by increasing apoptosis and decreasing MMP expression? | {
"contexts": [
"To explore whether icaritin, a prenylflavonoid derivative of the Chinese tonic herb Epimedium, could suppress the proliferation of human osteosarcoma cells in vitro, and to elucidate the mechanisms of the action.",
"Human osteosarcoma SaOS2 cell line was used in the present study. The prolife... | Icaritin suppresses the proliferation of SaOS2 human osteosarcoma cells by increasing apoptosis and downregulating MMP expression. | yes |
24,598,936 | Does short-term TNF-alpha inhibition reduce short-term and long-term inflammatory changes post-ischemia/reperfusion in rat intestinal transplantation? | {
"contexts": [
"Tumor necrosis factor (TNF)-α inhibition was shown to reduce ischemia/reperfusion injury (IRI) after intestinal transplantation (ITX). We studied the effects of different TNFα inhibitors on acute IRI and long-term inflammatory responses in experimental ITX.",
"Orthotopic ITX was performed in ... | Infliximab significantly reduced both acute IRI and, as with other TNFα inhibitors, long-term inflammatory responses after rat ITX. TNFα inhibition may help diminish chronic inflammatory long-term effects and avoid chronic allograft enteropathy. | yes |
24,585,441 | Does polysialic acid/neural cell adhesion molecule modulate the formation of ductular reactions in liver injury? | {
"contexts": [
"In severe liver injury, ductular reactions (DRs) containing bipotential hepatic progenitor cells (HPCs) branch from the portal tract. Neural cell adhesion molecule (NCAM) marks bile ducts and DRs, but not mature hepatocytes. NCAM mediates interactions between cells and surrounding matrix; however... | PolySia modification of NCAM+ ductules weakens cell-cell and cell-matrix interactions, allowing DRs/HPCs to migrate for normal development and regeneration. Modulation of polySia levels may provide a therapeutic option in liver regeneration. | yes |
24,607,485 | Do calcium phosphate particulates increase friction in the rat knee joint? | {
"contexts": [
"Basic calcium phosphate (BCP) particulates are commonly found in cartilage and synovial fluid of osteoarthritis (OA) joints with the amount of BCP correlating with knee OA severity. How cartilage mineralization affects joint degeneration has yet to be determined. The objective of this study was t... | The increased joint friction with BCP particulates suggests BCPs may play a role in articular surface degradation and OA development. | yes |
24,589,330 | Does quantification of skeletal metastases in castrate-resistant prostate cancer predict progression-free and overall survival? | {
"contexts": [
"To report a simplified and effective method for substratification of M1 castrate-resistant prostate cancer (CRPC) by correlating progression-free (PFS) and overall survival (OS) with simple quantification of skeletal metastases.",
"In all, 561 men with M1 CRPC were studied longitudinally. Ind... | Dichotomising patients with CRPC into cohorts with 1-4 or ≥5 skeletal metastases identifies a better and a worse cohort in a manner that is easy and clinically accessible. This simple method facilitates disease stratification and patient management, enabling clinicians to counsel patients more effectively about long-te... | yes |
24,614,825 | Is obesity associated with worse overall survival in women with low-grade papillary serous epithelial ovarian cancer? | {
"contexts": [
"The objective of this study was to evaluate prognostic risk factors for survival in women with low-grade serous epithelial ovarian cancer (LGSC).",
"A multicenter retrospective analysis of patients with LGSC was conducted. Potential epidemiologic risk factors evaluated included obesity, age, ... | In a multivariate analysis, obesity and optimal tumor cytoreduction were significant predictors of OS. However, obesity was not associated with worse disease-specific survival, suggesting that mortality of obese patients with LGSC may result from other comorbidities. Interventions addressing obesity may improve surviva... | yes |
24,598,367 | Is invasive adenocarcinoma of the lung associated with the upper lung regions? | {
"contexts": [
"We postulated that ventilation-perfusion (V/Q) relationships within the lung might influence where lung cancer occurs. To address this hypothesis we evaluated the location of lung adenocarcinoma, by both tumor lobe and superior-inferior regional distribution, and associated variables such as emph... | Invasive adenocarcinoma of the lung is highly associated with the upper lung regions. This association is not related to smoking, history of COPD, or total emphysema. The regional distribution of invasive adenocarcinoma may be due to V/Q relationships or other local factors. | yes |
24,590,155 | Do acute inflammatory biomarker profiles predict depression risk following moderate to severe traumatic brain injury? | {
"contexts": [
"To examine whether acute inflammation profiles predict posttraumatic depression (PTD) risk 6 and 12 months after traumatic brain injury.",
"University-affiliated level 1 trauma center and community.",
"Adults with moderate to severe traumatic brain injury (acute serum levels: n = 50; acut... | Acute CSF IBR scores show promise for identifying individuals at risk for PTD. Further research should assess acute CSF inflammatory biomarkers' relationships to chronic inflammation as a mechanism of PTD and should explore anti-inflammatory treatments for PTD, as well as prevention and screening protocols, and link in... | yes |
24,598,441 | Does dynamic contrast-enhanced micro-computed tomography correlate with 3-dimensional fluorescence ultramicroscopy in antiangiogenic therapy of breast cancer xenografts? | {
"contexts": [
"Dynamic contrast-enhanced (DCE) micro-computed tomography (micro-CT) has emerged as a valuable imaging tool to noninvasively obtain quantitative physiological biomarkers of drug effect in preclinical studies of antiangiogenic compounds. In this study, we explored the ability of DCE micro-CT to as... | Noninvasive DCE micro-CT provides valuable physiological information of antiangiogenic drug effect in the intact animal and correlates with ex vivo structural analysis of 3D UM. The combined use of DCE micro-CT with UM constitutes a complementary imaging toolset that can help to enhance our understanding of antiangioge... | yes |
24,604,562 | Is c5a/C5aR pathway essential for the pathogenesis of murine viral fulminant hepatitis by way of potentiating Fgl2/fibroleukin expression? | {
"contexts": [
"Viral fulminant hepatitis (FH) remains a serious clinical problem with very high mortality. Lacking understanding of FH pathogenesis has in essence hindered efficient clinical treatment. Inferring from a correlation observed between the genetic differences in the complement component 5 (C5) and t... | These data provide evidence that mouse susceptibility to MHV-3-induced FH may rely on C5a/C5aR interactions, for which ERK1/2 and p38 pathways participate in up-regulating Fgl2 expression. Inhibition of C5a/C5aR interactions is expected to be beneficial in the clinical treatment of FH patients. | yes |
24,589,563 | Is s-adenosylhomocysteine associated with subclinical atherosclerosis and renal function in a cardiovascular low-risk population? | {
"contexts": [
"Although homocysteine has been proposed as a cardiovascular risk factor, interventional trials lowering homocysteine have not consistently demonstrated clinical benefit. Recent evidence proposed the homocysteine metabolite S-adenosylhomocysteine (SAH) rather than homocysteine itself as the real c... | In summary, cardiovascular risk factors, subclinical atherosclerosis and eGFR are more strongly associated with SAH than with homocysteine in apparently healthy subjects. Thus, SAH might represent a more promising target to prevent cardiovascular disease than homocysteine. | yes |
24,602,274 | Do bacterial communities on classroom surfaces vary with human contact? | {
"contexts": [
"Humans can spend the majority of their time indoors, but little is known about the interactions between the human and built-environment microbiomes or the forces that drive microbial community assembly in the built environment. We sampled 16S rRNA genes from four different surface types throughou... | Our results indicate that human-associated microbial communities can be transferred to indoor surfaces following contact, and that such transmission is possible even when contact is indirect, but that proximity to other surfaces in the classroom does not influence community composition. | yes |
24,603,056 | Does calcium sensing receptor promote cardiac fibroblast proliferation and extracellular matrix secretion? | {
"contexts": [
"Calcium-sensing receptor (CaR) acts as a G protein coupled receptor that mediates the increase of the intracellular Ca(2+) concentration. The expression of CaR has been confirmed in various cell types, including cardiomyocytes, smooth muscle cells, neurons and vascular endothelial cells. However,... | Our results are the first report that CaR plays an important role in Ca(2+) signaling involved in cardiac fibrosis through the phospholipase C- inositol 3,4,5 phosphate (PLC-IP3) pathway. | yes |
24,608,110 | Are polymorphisms in the insulin-like growth factor axis associated with gastrointestinal cancer? | {
"contexts": [
"Numerous factors influence the development of gastrointestinal (GI) cancer. The insulin-like growth factor (IGF) axis plays a role in embryonic and postnatal growth and tissue repair. Elevated levels of IGFs, low levels of IGF binding proteins (IGFBPs) and over-expression of IGF receptor (IGFR-I)... | The A allele of SNP rs6214 in the IGF-I gene was associated with EAC, and with HNC in women. The GC genotype of rs6898743 in the GHR gene was negatively associated with ESCC. | yes |
24,604,911 | Does acute administration of haloperidol influence 123I-FP-CIT binding to the dopamine transporter? | {
"contexts": [
"A recent (123)I-FP-CIT ((123)-I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane) SPECT study on rats suggested that a single 1 mg/kg dose of the antipsychotic haloperidol induces enough dopamine release to compete with (123)I-FP-CIT for binding to the dopamine transporter. Taking int... | Changes in synaptic dopamine due to acute haloperidol administration were not detectable with (123)I-FP-CIT. | no |
24,589,248 | Does hydrogen sulfide accelerate cell cycle progression in oral squamous cell carcinoma cell lines? | {
"contexts": [
"To investigate the cell cycle regulator role of the third gaseous transmitter hydrogen sulfide (H2 S) in three oral SCC cell lines by using NaHS, a donor of H2 S.",
"The synchronized oral squamous cell carcinoma cell lines (Cal27, GNM, and WSU-HN6) were treated with different concentrations o... | H2 S is a potential pro-proliferative factor of human oral SCC cells that accelerates the progression of the SCC cell cycle; thus, H2 S plays a deleterious role in oral SCC cancer development. | yes |
24,617,422 | Do transforming growth factor-β1-induced Treg cells inhibit the absorption of tissue-engineered cartilage caused by endogenous IFN-γ and TNF-α? | {
"contexts": [
"In a previous study, we showed that IFN-γ and TNF-α induce bone marrow mesenchymal stem cell (BMMSC) apoptosis and absorption of tissue-engineered cartilage, but the induced regulatory T cells (iTreg) inhibit the function of IFN-γ and TNF-α. In this study, we investigated the effect of iTreg cell... | CD4(+) T cells led to the absorption of tissue-engineered cartilage through the secretion of endogenous IFN-γ and TNF-α, whose inflammatory functions were concomitantly suppressed by iTreg cells converted from CD4(+) T cells. This study is clinically relevant and adds to our understanding of the mechanism of tissue-eng... | yes |
24,614,927 | Is fibrous cartilage of human menisci less shock-absorbing and energy-dissipating than hyaline cartilage? | {
"contexts": [
"To test meniscal mechanical properties such as the dynamic modulus of elasticity E* and the loss angle δ at two loading frequencies ω at different locations of the menisci and compare it to E* and δ of hyaline cartilage in indentation mode with spherical indenters.",
"On nine pairs of human m... | In dynamic measurements with a spherical indenter, the menisci are much softer and less energy-dissipating than hyaline cartilage. Further, the menisci are stiffer and less energy-dissipating in the middle, intermediate part compared to the meniscal base. In compression, the energy dissipation of meniscus cartilage pla... | yes |
24,595,077 | Are heterogeneous nuclear ribonucleoprotein U-like 1 and Poly ( ADP-ribose ) polymerase 1 downregulated in renal cell carcinoma and connected with the prognosis? | {
"contexts": [
"To examine the expression of heterogeneous nuclear ribonucleoprotein U-like 1 (hnRPUL1) and poly (ADP-ribose) polymerase 1 (PARP-1) in renal cell carcinoma (RCC) tissues and the connection between the expressions and prognosis of RCC.",
"Total RNAs were extracted from 36 pairs of RCC and thei... | Despite the limitations, hnRPUL1 and PARP1 were downregulated in renal cell carcinoma and connected with the prognosis. | yes |
24,595,078 | Is iL-17A elevated in sera of patients with poorly differentiated ovarian papillary serous cystadenocarcinoma? | {
"contexts": [
"IL-17A a member of IL-17 family of cytokines is an inflammatory cytokine produced by a subset of CD4+ T cells that links innate and adaptive immunity. IL-17A has been shown to be a key mediator of inflammation in autoimmune diseases, transplant rejection and cancers.",
"To investigate the lev... | Elevation of IL-17A in a high percentage of ovarian serous cystadenocarcinoma and lack of this cytokine in healthy individuals makes it a specific candidate in diagnosis, follow up or immunotherapy. | yes |
24,603,132 | Are non-visualized pregnancy losses prognostically important for unexplained recurrent miscarriage? | {
"contexts": [
"Are non-visualized pregnancy losses (biochemical pregnancy loss and failed pregnancy of unknown location combined) in the reproductive history of women with unexplained recurrent miscarriage (RM) negatively associated with the chance of live birth in a subsequent pregnancy?"
],
"labels": [
... | Non-visualized pregnancy losses contribute negatively to the chance for live birth: each non-visualized pregnancy loss confers a relative risk (RR) for live birth of 0.90 (95% CI 0.83; 0.97), equivalent to the RR conferred by each additional clinical miscarriage. | yes |
24,602,480 | Does resveratrol prevent neuronal apoptosis in an early brain injury model? | {
"contexts": [
"Resveratrol has been shown to attenuate cerebral vasospasm after subarachnoid hemorrhage (SAH); however, no study has explored its neuroprotective effect in early brain injury (EBI) after experimental SAH. The aim of this study was to evaluate the antiapoptotic function of resveratrol in EBI and ... | Our results show that resveratrol has an antiapoptotic effect in EBI and that resveratrol might act through the PI3K/Akt signaling pathway. | yes |
24,586,903 | Does serum and glucocorticoid-inducible kinase1 increase plasma membrane wt-CFTR in human airway epithelial cells by inhibiting its endocytic retrieval? | {
"contexts": [
"Chloride (Cl) secretion by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) located in the apical membrane of respiratory epithelial cells plays a critical role in maintenance of the airway surface liquid and mucociliary clearance of pathogens. Previously, we and others have shown t... | This study demonstrates for the first time that SGK1 selectively increases wt-CFTR in the plasma membrane of human airway epithelia cells by inhibiting its endocytic retrieval from the membrane. | yes |
24,586,900 | Do human adipose tissue-derived stromal/stem cells promote migration and early metastasis of triple negative breast cancer xenografts? | {
"contexts": [
"Fat grafting is used to restore breast defects after surgical resection of breast tumors. Supplementing fat grafts with adipose tissue-derived stromal/stem cells (ASCs) is proposed to improve the regenerative/restorative ability of the graft and retention. However, long term safety for ASC grafti... | Human ASCs derived from abdominal lipoaspirates of two donors stimulated metastasis of MDA-MB-231 breast tumor xenografts to multiple mouse organs. MDA-MB-231 tumors co-injected with ASCs from one donor exhibited partial EMT, expression of MMP-9, and increased angiogenesis. | yes |
24,613,364 | Does urinary neutrophil gelatinase-associated lipocalin predict kidney outcome and death in patients with cirrhosis and bacterial infections? | {
"contexts": [
"Infections in cirrhosis are frequently complicated by kidney dysfunction that entails a poor prognosis. Urinary biomarkers may be of potential clinical usefulness in this setting. We aimed at assessing the value of urinary neutrophil gelatinase-associated lipocalin (uNGAL), a biomarker overexpres... | In patients with cirrhosis and infections, measurement of urinary NGAL at infection diagnosis is useful in predicting important clinical outcomes, specifically persistency and type of AKI, development of a second infection, and 3-month mortality. | yes |
24,615,422 | Is the open latarjet procedure more reliable in terms of shoulder stability than arthroscopic bankart repair? | {
"contexts": [
"Arthroscopic Bankart repair and open Latarjet bone block procedure are widely considered mainstays for surgical treatment of recurrent anterior shoulder instability. The choice between these procedures depends mainly on surgeon preference or training rather than published evidence.",
"We comp... | Patients who had the open Latarjet procedure had less recurrent instability and better Rowe scores over a mean 6-year followup. We now perform isolated arthroscopic Bankart repair for carefully selected patients, including patients with an Instability Severity Index Score of 3 or less. | yes |
24,614,203 | Do cognitive complaints correlate with depression rather than concurrent objective cognitive impairment in the successful aging evaluation baseline sample? | {
"contexts": [
"Whether subjective cognitive complaints are suggestive of depression or concurrent cognitive impairment in older adults without dementia remains unclear. The current study examined this question in a large (N = 1000), randomly selected, community-based sample of adults aged 51 to 99 years without... | Subjective cognitive complaints are more likely related to symptoms of depression rather than concurrent cognitive impairment in a large cross-section of community-dwelling adults without a formal diagnosis of dementia. | yes |
24,600,079 | Are serum endostatin concentrations higher in men with symptoms of intermittent claudication? | {
"contexts": [
"A cleavage fragment of collagen XVIII, endostatin, is released into the circulation and has been demonstrated to have antiangiogenic effects in animal models. We hypothesized that circulating endostatin would be increased in patients with symptoms of lower limb peripheral artery disease.",
"C... | Serum endostatin is raised in older men who have symptoms of intermittent claudication. The role of endostatin in the genesis and outcome of peripheral artery disease requires further investigation. | yes |
24,597,620 | Is secukinumab treatment in rheumatoid arthritis associated with incremental benefit in the clinical outcomes and HRQoL improvements that exceed minimally important thresholds? | {
"contexts": [
"The primary aim of rheumatoid arthritis (RA) treatment is to induce remission, the absence of disease activity. The objective of this study was to explore the association between clinical endpoints used to gauge RA treatment efficacy and patient-reported outcomes of health-related quality of life... | Results of this study show considerable agreement between minimal thresholds of improvement established for PROs and clinical outcome measures used in RA treatment studies and provide thresholds to be considered in gauging the importance of a treatment effect that goes beyond what is considered as minimally important f... | yes |
24,585,362 | Is a cam deformity gradually acquired during skeletal maturation in adolescent and young male soccer players : a prospective study with minimum 2-year follow-up? | {
"contexts": [
"A cam deformity is a major risk factor for hip osteoarthritis, and its formation is thought to be influenced by high-impact sporting activities during growth.",
"To (1) prospectively study whether a cam deformity can evolve over time in adolescents and whether its formation only occurs during... | In youth soccer players, cam deformities gradually develop during skeletal maturation and are probably stable from the time of growth plate closure. The formation of a cam deformity might be prevented by adjusting athletic activities during a small period of skeletal growth, which will have a major effect on the preval... | yes |
24,587,013 | Does plasma D-dimer predict short-term poor outcome after acute ischemic stroke? | {
"contexts": [
"Haemostatic biomarkers associated with poor outcome in acute ischemic stroke (AIS). The objective of the study was to evaluate the predictive value of plasma D-dimer (D-D) on functional outcome at 90-day follow-up from stroke onset.",
"We conducted a prospective, observational cohort study in... | D-D levels are a useful tool to predict outcome and mortality 90-day after acute ischemic stroke and have a potential to assist clinicians. | yes |
24,603,680 | Do scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis? | {
"contexts": [
"Thymocyte apoptosis is a major event in sepsis; however, how this process is regulated remains poorly understood.",
"Septic stress induces glucocorticoids production which triggers thymocyte apoptosis. Here, we used scavenger receptor BI (SR-BI)-null mice, which are completely deficient in in... | The findings in this study reveal a novel regulatory mechanism of thymocyte apoptosis in sepsis by SR-BI and HDL. | yes |
24,608,303 | Is tumor deposit a poor prognostic indicator for patients who have stage II and III colorectal cancer with fewer than 4 lymph node metastases but not for those with 4 or more? | {
"contexts": [
"Extranodal tumor deposits are involved in TNM classification. However, it is uncertain whether a tumor deposit is a regular lymph node metastasis, and its prognostic significance in patients with stage II or III colorectal cancer remains to be established.",
"This study aimed to determine the... | Our study was a single-institution retrospective study, and the numbers of patients were relatively small to draw firm conclusions. | yes |
24,613,069 | Does selective inhibition of histone deacetylase 6 alter the composition of circulating blood cells in a lethal septic model? | {
"contexts": [
"Phagocytes, especially monocytes, macrophages, and dendritic cells, play a pivotal role in the innate and adaptive immune responses during sepsis. We have shown that inhibition of histone deacetylase 6 improves survival and increases bacterial clearance in a mouse model of cecal ligation and punc... | Tubastatin A treatment has significant impact on the composition of circulating blood cells. It increases the number of circulating monocytes and the red blood cell mass in sham-operated animals. In the CLP animals, it increases the monocyte count, decreases the percentage of granulocytes, restores the lymphocyte popul... | yes |
24,593,279 | Do tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients? | {
"contexts": [
"Experimental and clinical data suggest that solid cancers contain treatment-resistant cancer stem cells that will impair treatment efficacy. The objective of this study was to investigate if head and neck squamous cell carcinoma (HNSCC) also contain cancer stem cells that can be identified by low... | Subpopulations of HNSCC display stem cell features that affect patients' tumor control and survival. Evaluating cancer tissue for expression of the proteasome subunit PSMD1 may help identify patients at risk for relapse. | yes |
24,606,756 | Does population analysis of Vibrio parahaemolyticus originating from different geographical regions demonstrate a high genetic diversity? | {
"contexts": [
"Vibrio parahaemolyticus is frequently isolated from environmental and seafood samples and associated with gastroenteritis outbreakes in American, European, Asian and African countries. To distinguish between different lineages of V. parahaemolyticus various genotyping techniques have been used, i... | Our study reveals a high genetic diversity in the analyzed V. parahaemolyticus strain set as well as for geographical strain subsets, with a high proportion of newly discovered alleles and STs. Differences between the subsets were identified. Our data support the postulated population structure of V. parahaemolyticus w... | yes |
24,606,754 | Does [ Vacuum sealing drainage promote experimental pig explosive abdomen wound healing ]? | {
"contexts": [
"To explore the roles of vacuum sealing drainage (VSD) in controlling infection and promoting healing on the experimental pigs with blast injury in the abdomen and exposed internal organs.",
"All animals with full-thickness abdominal wall defect were randomly divided into experimental group (V... | VSD can effectively control the amount of bacteria in the wound, and reduce the expressions of pro-inflammatory factors such as TNF-α, IL-1 and IL-6 in drainage fluid. VSD also promotes the expressions of growth factors in the wound. | yes |
24,611,676 | Does curcumin attenuate fructose-induced vascular dysfunction of isolated rat thoracic aorta rings? | {
"contexts": [
"Consumption of high fructose is associated with metabolic abnormalities, insulin resistance, and hypertension. It is not known whether this hypertensive effect of fructose is related to metabolic abnormalities or due to the direct effect of fructose on blood vessels.",
"Here, we investigated ... | Fructose strongly increased the contractile response of aortic rings to both phenylephrine and KCl (Emax was increased by 147.3% and 150.5%, respectively) but it did not affect the relaxant response to Ach. Curcumin significantly decreased the hyper responsiveness of arterial rings to both vasopressors (for phenylephri... | yes |
24,603,611 | Is fADD upregulated in relapsing remitting multiple sclerosis? | {
"contexts": [
"To elucidate the role of tumor necrosis factor (TNF) receptor signal transduction in multiple sclerosis (MS).",
"We performed a cross-sectional analysis of the gene expression of TNF receptor-associated death domain protein (TRADD) and Fas-associated death domain protein (FADD) in peripheral ... | FADD elevation in leukocytes might be interpreted as the molecular equivalent of an elevated general inflammatory activity in RR MS patients compared to other disease courses. FADD elevation in RR MS reinforces the concept that different pathophysiological and immunological processes sustain RR MS and SP or PP MS. | yes |
24,596,388 | Does prolyl-isomerase Pin1 impair trastuzumab sensitivity by up-regulating fatty acid synthase expression? | {
"contexts": [
"Clinical trials have shown efficacy of the anti-HER2 monoclonal antibody trastuzumab in metastatic breast cancer patients. The aim of the present study was to elucidate the mechanisms by which up-regulation of fatty acid synthase (FAS) expression confers resistance to trastuzumab in HER2-positive... | Pin1-mediated FAS overexpression is a major regulator of trastuzumab-resistant breast cancer growth and survival. | yes |
24,587,076 | Does hydrogen sulfide inhibit formaldehyde-induced endoplasmic reticulum stress in PC12 cells by upregulation of SIRT-1? | {
"contexts": [
"Formaldehyde (FA), a well-known environmental pollutant, has been classified as a neurotoxic molecule. Our recent data demonstrate that hydrogen sulfide (H2S), the third gaseous transmitter, has a protective effect on the neurotoxicity of FA. However, the exact mechanisms underlying this protecti... | These data indicate that H2S exerts its protection against the neurotoxicity of FA through overcoming ER stress via upregulation of SIRT-1. Our findings provide novel insights into the protective mechanisms of H2S against FA-induced neurotoxicity. | yes |
24,586,471 | Are circulating immunoglobulins associated with intraplaque mast cell number and other vulnerable plaque characteristics in patients with carotid artery stenosis? | {
"contexts": [
"Recently, we have shown that intraplaque mast cell numbers are associated with atherosclerotic plaque vulnerability and with future cardiovascular events, which renders inhibition of mast cell activation of interest for future therapeutic interventions. However, the endogenous triggers that activ... | In patients suffering from carotid artery disease, total IgE, total IgG and oxLDL-IgG levels do not associate with plaque mast cell numbers or other vulnerable plaque histopathological characteristics. This study thus does not provide evidence that the immunoglobulins tested in our cohort play a role in intraplaque mas... | no |
24,612,549 | Does metformin enhance tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma? | {
"contexts": [
"Tamoxifen, an endocrine therapy drug used to treat breast cancer, is designed to interrupt estrogen signaling by blocking the estrogen receptor (ER). However, many ER-positive patients are low reactive or resistant to tamoxifen. Metformin is a widely used anti-diabetic drug with noteworthy anti-c... | The present work shows that metformin and tamoxifen additively inhibited the growth and augmented the apoptosis of ER-positive breast cancer cells. It provides leads for future research on this drug combination for the treatment of ER-positive breast cancer. | yes |
24,603,877 | Is the tumor necrosis factor α ( -308 A/G ) polymorphism associated with cystic fibrosis in Mexican patients? | {
"contexts": [
"Environmental and genetic factors may modify or contribute to the phenotypic differences observed in multigenic and monogenic diseases, such as cystic fibrosis (CF). An analysis of modifier genes can be helpful for estimating patient prognosis and directing preventive care. The aim of this study ... | An analysis of seven genetic variants of four modifier genes showed that one variant, the TNF2 allele, appears to be significantly associated with CF in Mexican patients. | yes |
24,598,599 | Does a whole-grain cereal-based diet lower postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome? | {
"contexts": [
"Until recently, very few intervention studies have investigated the effects of whole-grain cereals on postprandial glucose, insulin and lipid metabolism, and the existing studies have provided mixed results. The objective of this study was to evaluate the effects of a 12-week intervention with ei... | A twelve week whole-grain cereal-based diet, compared to refined cereals, reduced postprandial insulin and triglycerides responses. This finding may have implications for type 2 diabetes risk and cardiovascular disease. | yes |
24,614,799 | Does vasopressin improve survival compared with epinephrine in a neonatal piglet model of asphyxial cardiac arrest? | {
"contexts": [
"Epinephrine is a component of all resuscitation algorithms. Vasopressin is a pulmonary vasodilator and systemic vasopressor. We investigated the effect of epinephrine vs. vasopressin on survival and hemodynamics after neonatal porcine cardiac arrest (CA).",
"A 4-min asphyxial CA was induced, ... | Vasopressin results in improved survival, lower postresuscitation troponin, and less hemodynamic compromise after CA in newborn piglets. Vasopressin may be a candidate for testing in human neonates. | yes |
24,587,192 | Do syncytiotrophoblast vesicles show altered micro-RNA and haemoglobin content after ex-vivo perfusion of placentas with haemoglobin to mimic preeclampsia? | {
"contexts": [
"Cell-free foetal haemoglobin (HbF) has been shown to play a role in the pathology of preeclampsia (PE). In the present study, we aimed to further characterize the harmful effects of extracellular free haemoglobin (Hb) on the placenta. In particular, we investigated whether cell-free Hb affects th... | This study showed that Hb perfusion can alter the micro-RNA content of released STBMs. Of particular interest is the alteration of two placenta specific micro-RNAs; mir-517a and mir-517b. We have also seen that STBMs may function as carriers of Hb into the maternal circulation. | yes |
24,587,191 | Is elevated exhaled nitric oxide in allergen-provoked asthma associated with airway epithelial iNOS? | {
"contexts": [
"Fractional exhaled nitric oxide is elevated in allergen-provoked asthma. The cellular and molecular source of the elevated fractional exhaled nitric oxide is, however, uncertain.",
"To investigate whether fractional exhaled nitric oxide is associated with increased airway epithelial inducible... | Higher fractional exhaled nitric oxide concentration among asthmatics is associated with elevated iNOS mRNA in the bronchial epithelium. Furthermore, our data demonstrates for the first time increased expression and activity of iNOS in the bronchial epithelium after allergen provocation, and thus provide a mechanistic ... | yes |
24,603,508 | Is prehydration effective for rapid control of recalcitrant atopic dermatitis? | {
"contexts": [
"Skin care remains a key component in atopic dermatitis (AD) management; there are no data available guiding optimal bathing recommendations.",
"This study aims to determine whether 15-minute to 20-minute baths followed by topical corticosteroid application (prehydration therapy) are effective... | Prehydration followed by topical corticosteroid therapy seems to be a highly effective regimen that achieves rapid control of moderate to severe disease. | yes |
24,592,366 | Is the chemokine receptor CXCR4 associated with the staging of gastric cancer? | {
"contexts": [
"CXCR4 is a cognitive receptor for stromal-derived factor-1 (SDF-1) and has been previously shown to be associated with tumor growth and invasion of many cancers. However, its expression and function in gastric cancer has not been well clarified.",
"Herein, we studied the expression of CXCR4 o... | We present evidence that CXCR4 level is significantly elevated in later stages of gastric cancer. Thus, CXCR4 may play a crucial role in gastric cancer progression. | yes |
24,584,920 | Is impaired left ventricular apical rotation associated with disease activity of psoriatic arthritis? | {
"contexts": [
"Although early cardiovascular (CV) involvement has been found in patients with psoriatic arthritis (PsA), few studies have related this to PsA disease activity. The aim of our study was to evaluate left ventricular (LV) mechanics using novel, more sensitive techniques based on assessment of LV ro... | Subclinical impaired myocardial deformation was common in patients with PsA even without CV risk factors. Apical rotation was associated with the status of PsA disease activity. These new speckle tracking echocardiography techniques can detect subclinical myocardial involvement in PsA. | yes |
24,587,477 | Is high free fatty acid level associated with recurrent stroke in cardioembolic stroke patients? | {
"contexts": [
"To determine whether the plasma level of free fatty acid (FFA) could be associated with recurrent stroke in cardioembolic (CE) stroke patients.",
"We analyzed data from 669 acute ischemic stroke patients and examined the association between FFA concentration and recurrent stroke in CE stroke ... | In this retrospective registry-based observational study, CE stroke seemed to be associated with elevated plasma level of FFA. In addition, the present study suggested that an elevated FFA concentration could be a useful indicator for predicting recurrent stroke in CE stroke patients. | yes |
24,605,206 | Do a comparative study of gold UCLA-type and CAD/CAM titanium implant abutments? | {
"contexts": [
"The aim of this study was to evaluate the interface accuracy of computer-assisted designed and manufactured (CAD/CAM) titanium abutments and implant fixture compared to gold-cast UCLA abutments.",
"An external connection implant system (Mark III, n=10) and an internal connection implant syste... | In conclusion, CAD/CAM milled titanium abutment can be fabricated with sufficient accuracy to permit screw joint stability between abutment and fixture comparable to that of the traditional gold cast UCLA abutment. | yes |
24,613,834 | Does anti-miR-197 inhibit migration in HCC cells by targeting KAI 1/CD82? | {
"contexts": [
"To investigate the metastatic effects and mechanisms of miR-197 in hepatocellular carcinoma (HCC).",
"The levels of miR-197 increased in HCC cells and tissues compared with a normal hepatic cell line (LO2) and adjacent nontumorous liver tissues, respectively. miR-197 expression negatively cor... | Taken together, these data suggest that anti-miR-197 suppresses HCC migration and invasion by targeting CD82. The regulation of the miR-197/CD82 axis could be a novel therapeutic target in future HCC effective therapy. | yes |
24,612,634 | Do pPARγ agonists regulate tobacco smoke-induced Toll like receptor 4 expression in alveolar macrophages? | {
"contexts": [
"Peroxisome proliferator-activated receptor-gamma (PPARγ) is a ligand-activated transcription factor that exerts multiple biological effects. Growing evidence suggests that PPARγ plays an important role in inflammation; however, the effects of this transcription factor on the inflammation caused b... | These results suggest that PPARγ agonists regulate inflammation in alveolar macrophages and may play a role in inflammatory diseases such as COPD. | yes |
24,606,807 | Do α4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets? | {
"contexts": [
"Natalizumab blocks α4-integrins and is a prototypic agent for a series of anti-inflammatory drugs that impair trafficking of immune cells into the CNS. However, modulation of the access of immune cells to the CNS is associated with impaired immune surveillance and detrimental viral infections of ... | The quality of the intrathecal cellular antiviral response under conditions of impaired VLA-4 function jeopardizes host protection. Our functional in vivo data extend our mechanistic understanding of anti-viral immunity in the CNS and help to estimate the risk potential of upcoming therapeutic agents that target the tr... | yes |
24,606,809 | Is clock gene Bmal1 dispensable for intrinsic properties of murine hematopoietic stem cells? | {
"contexts": [
"Circadian rhythms are known to influence a variety of biological phenomena such as cell cycle, sleep-wake rhythm, hormone release and other important physiological functions. Given that cell cycle entry of hibernating hematopoietic stem cells (HSCs) plays a critical role in controlling hematopoie... | This paper discusses the necessity of circadian rhythms for HSC functions. Our data clearly shows that a key circadian clock gene Bmal1 is dispensable for intrinsic functions of HSCs, such as differentiation, proliferation and repopulating ability. | yes |
24,589,395 | Is dose always what it seems : where very misleading values can result from volume CT dose index and dose length product? | {
"contexts": [
"The volume CT dose index (CTDIvol) and the dose-length product, commonly reported for examinations performed on clinical CT scanners, should not be used as surrogates for patient dose. This is because significant under or overestimates of these actual values can occur when there is a mismatch bet... | Radiation dose estimates are more accurate when using the SSDE metric in lieu of the CTDIvol metric for reporting and comparing patient dose indices. | no |
24,607,782 | Is influence of parafascicular thalamic input on neuronal activity within the nucleus accumbens mediated by nitric oxide - an in vivo study? | {
"contexts": [
"Thalamostriatal fibers are involved in cognitive tasks such as acquisition, learning, processing of sensory events, and behavioral flexibility and might play a role in Parkinson's disease. The aim of the present study was the in vivo electrochemical characterization of the projection from the lat... | This study describes for the first time in vivo extracellular electrical responses of the dNAc on stimulation of the Pfl. Synaptic transmission within the dNAc on stimulation of the Pfl seems to be facilitated by NO. | yes |
24,607,784 | Does endothelin-1 regulate hypoxia-inducible factor-1α and -2α stability through prolyl hydroxylase domain 2 inhibition in human lymphatic endothelial cells? | {
"contexts": [
"Lymphangiogenesis, the formation of new lymphatic vessels, is thought to constitute a route for the tumor cells to metastasize. We previously demonstrated that endothelin-1 (ET-1) induces the expression of lymphangiogenic factors through hypoxia-inducible factor (HIF)-1α and HIF-2α. The stability... | These results reveal a PHD2-mediated mechanism through which ET-1 stabilizes HIF-1α and HIF-2α pathway thereby regulating LEC behavior and lymphangiogenesis. | yes |
24,586,589 | Are functional Fcgamma receptor polymorphisms associated with human allergy? | {
"contexts": [
"IgG Fc receptors (FcγRs) play important roles in immune responses. It is not clear whether FcγR receptors play a role in human asthma and allergy. The aim of current study was to investigate whether functional single nucleotide polymorphisms (SNPs) of FcγR genes (FCGR) are associated with human a... | FcγRIIA and FcγRIIB functional polymorphisms may have a role in the pathogenesis of allergy. | yes |
24,593,255 | Does p38 Mitogen-activated protein kinase accelerate emphysema in mouse model of chronic obstructive pulmonary disease? | {
"contexts": [
"There are few short-term mouse models of chronic obstructive pulmonary disease (COPD) mimicking the human disease. In addition, p38 is recently recognized as a target for the treatment of COPD. However, the precise mechanism how p38 contributes to the pathogenesis of COPD is still unknown.",
... | In a new experimental COPD mouse model, p38 accelerates the development of emphysema. | yes |
24,606,771 | Is a banana aquaporin gene , MaPIP1 ; 1 , involved in tolerance to drought and salt stresses? | {
"contexts": [
"Aquaporin (AQP) proteins function in transporting water and other small molecules through the biological membranes, which is crucial for plants to survive in drought or salt stress conditions. However, the precise role of AQPs in drought and salt stresses is not completely understood in plants.",... | Our results demonstrated that heterologous expression of banana MaPIP1;1 in Arabidopsis confers salt and drought stress tolerances by reducing membrane injury, improving ion distribution and maintaining osmotic balance. | yes |
24,614,724 | Does l-carnosine alter some hemorheologic and lipid peroxidation parameters in nephrectomized rats? | {
"contexts": [
"Chronic kidney disease (CKD) is a major health problem worldwide. Oxidative stress is one of the mediators of this disease. Systemic complications of oxidative stress are involved in the pathogenesis of hypertension, endothelial dysfunction, shortened erythrocyte lifespan, deformability, and nitr... | We found that carnosine has beneficial effects on CKD in terms of lipid peroxidation and RBC deformability. Carnosine may have a healing effect in microcirculation level, but may not have any effect on systemic blood pressure in CKD-induced rats. | yes |
24,597,515 | Is uniPR129 a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations? | {
"contexts": [
"The Eph receptor tyrosine kinases and their ephrin ligands are key players in tumorigenesis and many reports have correlated changes in their expression with a poor clinical prognosis in many solid tumours. Agents targeting the Eph-ephrin system might emerge as new tools useful for the inhibition... | The discovery of UniPR129 represents not only a major advance in potency compared with the existing Eph-ephrin antagonists but also an improvement in terms of cytotoxicity, making this molecule a useful pharmacological tool and a promising lead compound. | yes |
24,600,479 | Are patients With First-Episode Psychosis a Homogeneous Population : Implications for Treatment? | {
"contexts": [
"This study aimed at defining the characteristics of a population of patients diagnosed with first-episode psychosis (FEP), and accessing for the first time a center for early intervention in psychosis in the health district of Milan and its surroundings.",
"Patients were included in the study... | The findings of this study need replication in larger samples and on a wider severity scale. Nevertheless, the heterogeneity of patients with FEP might impact on treatment. Policymakers should recognize the importance of the diagnostic and outcome assessment in the treatment of severe mental disorders. | no |
24,602,318 | Is the effect of timing of cardiac catheterization on acute kidney injury after cardiac surgery influenced by the type of operation? | {
"contexts": [
"Acute kidney injury (AKI) is a vexing complication of cardiac surgery. Since exposure to contrast agents is a relevant contributing factor in the development of postoperative AKI, the optimal timing between cardiac catheterization and surgery is decisive.",
"A total of 2504 consecutive noneme... | Delaying cardiac surgery beyond 24h of exposure to contrast agents seems to be justified only in patients undergoing valve surgery with concomitant CABG. | yes |
24,598,051 | Is formation of the nitrative DNA lesion 8-nitroguanine associated with asbestos contents in human lung tissues : a pilot study? | {
"contexts": [
"Asbestos causes lung cancer and malignant mesothelioma, and chronic inflammation is considered to participate in carcinogenesis. However, biomarkers to evaluate its carcinogenic risk have not been established. Reactive oxygen/nitrogen species are generated in biological systems under inflammatory... | This is the first study to demonstrate that 8-nitroG formation is associated with asbestos contents in human lung tissues. This finding raises a possibility that 8-nitroG serves as a biomarker that can be used to evaluate asbestos exposure and carcinogenic risk. | yes |
24,589,349 | Do modulation of visual evoked potentials by high-frequency repetitive transcranial magnetic stimulation in migraineurs? | {
"contexts": [
"High-frequency repetitive transcranial magnetic stimulation (rTMS) modulates cortical excitability. We investigated its effect on visual evoked potentials (VEPs) in migraine.",
"Thirty-two headache-free controls (CO), 25 interictal (MINT) and 7 preictal migraineurs (MPRE) remained after exclu... | RTMS reduced habituation only in migraineurs, indicating increased responsivity to rTMS. The magnocellular visual subsystem may be affected interictally, while the parvocellular system may only be affected preictally. | yes |
24,594,117 | Is microRNA-21 a unique signature associated with coronary plaque instability in humans by regulating matrix metalloproteinase-9 via reversion-inducing cysteine-rich protein with Kazal motifs? | {
"contexts": [
"Coronary atherosclerotic unstable plaque is one of the leading causes of cardiovascular death. Macrophage-derived matrix metalloproteinase (MMP) 9 is considered for degrading extracellular matrix and collagen, thereby thinning the fibrous cap in plaques. miR-21 is implicated to play an important ... | miR-21 might be a biomarker for plaque instability by suppressing target gene RECK to promote the expression and secretion of MMP-9 in macrophages. | yes |
24,589,638 | Do stro-1-positive BMSCs predict postoperative periprosthetic bone mineral density outcomes in uncemented total hip arthroplasty patients? | {
"contexts": [
"Bone marrow cell profiles are variable after total hip arthroplasty (THA), including variable levels of Stro-1+ and bone morphogenetic protein receptor (BMPRs)+ cells. We investigated the impact of bone marrow cell profiles on changes in periprosthetic bone mineral density (BMD) in uncemented THA... | Elevated Stro-1+ bone marrow cell profile may be a useful prognostic indicator for uncemented THA patients. | yes |
24,589,631 | Is six weeks of unsupervised Nintendo Wii Fit gaming effective at improving balance in independent older adults? | {
"contexts": [
"To determine the effectiveness of unsupervised Nintendo Wii Fit balance training in older adults.",
"Forty-one older adults were recruited from local retirement villages and educational settings to participate in a six-week two-group repeated measures study. The Wii group (n = 19, 75 ± 6 year... | Six weeks of unsupervised Wii balance training is an effective modality for improving balance in independent older adults. | yes |
24,596,468 | Is management of sacroiliac joint disruption and degenerative sacroiliitis with nonoperative care medical resource-intensive and costly in a United States commercial payer population? | {
"contexts": [
"Low back pain is common and originates in the sacroiliac (SI) joint in 15%-30% of cases. Traditional SI joint disruption/degenerative sacroiliitis treatments include nonoperative care or open SI joint fusion. To evaluate the usefulness of newly developed minimally-invasive technologies, the costs... | The economic burden of SI joint disruption among privately-insured patients in the US is substantial, highlighting the need for more cost-effective therapies. | yes |
24,595,591 | Does hypoperfusion intensity ratio predict infarct progression and functional outcome in the DEFUSE 2 Cohort? | {
"contexts": [
"We evaluate associations between the severity of magnetic resonance perfusion-weighted imaging abnormalities, as assessed by the hypoperfusion intensity ratio (HIR), on infarct progression and functional outcome in the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution ... | HIR can be easily assessed on automatically processed perfusion maps and predicts the rate of collateral flow, infarct growth, and clinical outcome. | yes |
24,606,587 | Does information compression exploit patterns of genome composition to discriminate populations and highlight regions of evolutionary interest? | {
"contexts": [
"Genomic information allows population relatedness to be inferred and selected genes to be identified. Single nucleotide polymorphism microarray (SNP-chip) data, a proxy for genome composition, contains patterns in allele order and proportion. These patterns can be quantified by compression effici... | We conclude with a discussion of the implications of CE for a complex systems science view of genome evolution. CE allows one to clearly visualise the evolution of individual genomes and populations through a formal, mathematically-rigorous information space. Overall, CE makes a set of biological predictions, some of w... | yes |
24,607,847 | Do extracts of irradiated mature human tooth crowns contain MMP-20 protein and activity? | {
"contexts": [
"We recently demonstrated a significant correlation between enamel delamination and tooth-level radiation dose in oral cancer patients. Since radiation can induce the synthesis and activation of matrix metalloproteinases, we hypothesized that irradiated teeth may contain active matrix metalloprote... | MMP-20 is a radiation-resistant component of mature tooth crowns enriched in the dentine-enamel. We speculate that MMP-20 catalyzed degradation of organic matrix at this site could lead to enamel delamination associated with oral cancer radiotherapy. | yes |
24,598,081 | Does pten regulate homeostasis and inflammation-induced migration of myelocytes in zebrafish? | {
"contexts": [
"Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) is frequently observed in hematopoietic malignancies. Although PTEN has been implicated in maintaining the quiescence of hematopoietic stem cells (HSCs), its role in hematopoiesis during ontogeny remains largely unexplored.",
... | Our data provide in vivo evidence that definitive myelopoiesis in zebrafish is critically regulated by pten via the elevation of cebpa expression. | yes |
24,598,082 | Does a bacterial extract of OM-85 Broncho-Vaxom prevent allergic rhinitis in mice? | {
"contexts": [
"According to the hygiene hypothesis, bacterial infections during early life contribute to a reduced incidence of asthma in animals. However, the effects of microbial products at a safe dose and within a rational time course on the prevention of allergic rhinitis (AR) have been inconclusive. This ... | Taken together, our data suggested that OM-85 BV is a low-cost alternative candidate to prevent AR with simple oral administration. | yes |
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