pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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24,605,225 | Does lentivirus vector-mediated Rho guanine nucleotide dissociation inhibitor 2 induce beta-2 adrenergic receptor desensitization in β2AR desensitization mice model? | {
"contexts": [
"It is well-known that chronic administration of β2AR agonists can induce β2AR desensitization. Our previous study showed that Rho guanine nucleotide dissociation inhibitor 2 (RhoGDI2) overexpression induced beta-2 adrenergic receptor (β2AR) desensitization in airway smooth muscle cells. The purpo... | To sum up, our present studies found that RhoGDI2 might induce β2AR desensitization and GRK2 might take part in RhoGDI2-mediated β2AR desensitization. | yes |
24,605,224 | Does transplantation of umbilical cord mesenchymal stem cells alleviate pneumonitis of MRL/lpr mice? | {
"contexts": [
"To investigate whether the umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in the MRL/lpr mice has effect or not on their pneumonitis and the possible mechanisms underlying this treatment.",
"Twenty four 18-week-old MRL/lpr female mice were divided into three groups as followi... | These findings indicate that UC-MSCs have a therapeutic effect on systemic lupus erythematosus (SLE) pneumonitis, possibly by inhibiting HMGB-1 expression, which suggests a potential application of UC-MSCs in the treatment of human lupus. | yes |
24,612,047 | Do epithelial attachment and downgrowth on dental implant abutments -- a comprehensive review? | {
"contexts": [
"The soft tissues around dental implants are enlarged compared with the gingiva because of the longer junctional epithelium and the hemidesmosonal attachments are fewer, suggestive of a poorer quality attachment. Inflammatory infiltrates caused by bacterial colonization of the implant-abutment int... | Based on the review of current literature, the authors recommend inserting definitive abutments at the time of surgical uncovering. To implement this concept, registration of the implant position should to be taken at the time of surgical implant placement. | yes |
24,606,015 | Does enhanced glucocorticoid-induced leucine zipper in dendritic cells induce allergen-specific regulatory CD4 ( + ) T-cells in respiratory allergies? | {
"contexts": [
"Respiratory allergies rely on a defect of IL-10-secreting regulatory CD4(+) T-cells (IL-10-Tregs ) leading to excessive Th2-biased immune responses to allergens. According to clinical data, the restoration of allergen-specific IL-10-Tregs is required to control respiratory allergies and cure pati... | This proof of concept study shows that the re-establishment of GILZ expression in patients' DCs to normal levels restores their capacity to activate allergen-specific IL-10-Tregs . We thus highlight the up-regulation of GILZ in DCs as a new interventional approach to restore the immune tolerance to allergens. | yes |
24,586,605 | Do bRAF-V600 mutations have no prognostic impact in stage IV melanoma patients treated with monochemotherapy? | {
"contexts": [
"The impact of BRAF tumor mutations on the natural course of disease of melanoma patients is controversial.",
"We analyzed the mutational status and overall survival of 215 patients receiving treatment with dacarbazine or temozolomide. All patients who started first-line treatment at our insti... | No differences in prognosis were observed according to the BRAF mutational status in patients with distant metastasis treated with monochemotherapy. | yes |
24,614,245 | Does a pepper MSRB2 gene confer drought tolerance in rice through the protection of chloroplast-targeted genes? | {
"contexts": [
"The perturbation of the steady state of reactive oxygen species (ROS) due to biotic and abiotic stresses in a plant could lead to protein denaturation through the modification of amino acid residues, including the oxidation of methionine residues. Methionine sulfoxide reductases (MSRs) catalyze t... | Our results indicate that CaMSRB2 might play an important functional role in chloroplasts for conferring drought stress tolerance in rice. | yes |
24,613,312 | Is sLEEPLESS a bifunctional regulator of excitability and cholinergic synaptic transmission? | {
"contexts": [
"Although sleep is conserved throughout evolution, the molecular basis of its control is still largely a mystery. We previously showed that the quiver/sleepless (qvr/sss) gene encodes a membrane-tethered protein that is required for normal sleep in Drosophila. SLEEPLESS (SSS) protein functions, at... | Together, our data point to an evolutionarily conserved, bifunctional role for SSS and its homologs in controlling excitability and synaptic transmission in fundamental processes of the nervous system such as sleep. | yes |
24,587,824 | Does tolcapone addition improve Parkinson 's disease associated nonmotor symptoms? | {
"contexts": [
"Addition of catechol-O-methyltransferase inhibitors to a conventional levodopa/dopadecarboxylase inhibitor regimen improves motor symptoms in patients with Parkinson's disease. Optimizing dopamine substitution is also beneficial for nonmotor features.",
"To investigate the efficacy of supplem... | This trial demonstrates that tolcapone addition may improve nonmotor features. | yes |
24,598,567 | Does culturally competent transplant program improve Hispanics ' knowledge and attitudes about live kidney donation and transplant? | {
"contexts": [
"Hispanics receive disproportionately fewer live donor kidney transplants than non-Hispanic whites. Increasing Hispanics' knowledge and changing attitudes about live kidney donation may reduce these disparities.",
"To evaluate the effectiveness of culturally and linguistically competent educat... | The educational sessions provided by the Hispanic Transplant Program effectively addressed commonly shared Hispanic concerns about live kidney donation. Culturally congruent education increased Hispanic patients' and family members' knowledge and improved attitudes about live donor kidney transplants. | yes |
24,589,480 | Is chemokine ( C-C motif ) receptor 5 an important pathological regulator in the development and maintenance of neuropathic pain? | {
"contexts": [
"The chemokine family has been revealed to be involved in the pathogenesis of neuropathic pain. In this study, the authors investigated the role of chemokine (C-C motif) ligand 3 and its receptors chemokine (C-C motif) receptor 1 and chemokine (C-C motif) receptor (CCR) 5 in neuropathic pain.",
... | Pharmacological blockade of CCR5 was effective in the treatment of the development and maintenance phases of neuropathic pain. Thus, CCR5 antagonists may be potential new drugs for the treatment of neuropathic pain. | yes |
24,589,481 | Does disruption of hippocampal neuregulin 1-ErbB4 signaling contribute to the hippocampus-dependent cognitive impairment induced by isoflurane in aged mice? | {
"contexts": [
"A prolonged isoflurane exposure may lead to cognitive decline in rodents. Neuregulin 1 (NRG1)-ErbB4 signaling plays a key role in the modulation of hippocampal synaptic plasticity through regulating the neurotransmission. The authors hypothesized that hippocampal NRG1-ErbB4 signaling is involved ... | Disruption of NRG1-ErbB4 signaling in the parvalbumin-positive interneurons might, at least partially, contribute to the isoflurane-induced hippocampus-dependent cognitive impairment after exposure to isoflurane carried by 100% O2 in aged mice. | yes |
24,603,371 | Appear oral terbinafine and itraconazole treatments against dermatophytes to favor the establishment of Fusarium spp . in nail? | {
"contexts": [
"Fusarium onychomycoses are weakly responsive or unresponsive to standard onychomycosis treatments with oral terbinafine and itraconazole.",
"To examine whether the use of terbinafine and itraconazole, which are highly effective in fighting Trichophyton onychomycoses, could be a cause of the h... | Oral terbinafine and itraconazole treatments do not appear to favor the establishment of Fusarium spp. in onychomycosis. | no |
24,613,704 | Is genetic interaction of PICALM and APOE associated with brain atrophy and cognitive impairment in Alzheimer 's disease? | {
"contexts": [
"Evidence has emerged indicating that the ε4 allele of APOE and PICALM interact in conferring risk of Alzheimer's disease (AD). The biologic basis of this interaction is unclear, but it is likely to have phenotypic relevance and contribute to the structural and clinical heterogeneity of AD.",
... | The data suggest a neural mechanism for APOE-PICALM interactions in patients with manifest AD and indicate that the PICALM genotype modulates both brain atrophy and cognitive performance in APOE ε4 carriers. | yes |
24,594,993 | Do cytomegalovirus-specific responses of CD38⁺ memory T cells are skewed towards IFN-γ and dissociated from CD154 in HIV-1 infection? | {
"contexts": [
"Despite the strong correlation of T-cell CD38 expression with HIV disease progression, evidence linking CD38 expression and dysfunction at the single cell level is scant. Since CD38⁺ memory CD4⁺ T cells, especially those from HIV-infected persons, fail to induce CD154 (CD40L) while responding to ... | Patients' CD38⁺ memory CD4⁺T-cell responses to CMV favor the effector cytokine IFN-γ over IL-2, in the context of deficient CD154 induction, which may limit co-stimulation, proliferation and survival. | yes |
24,602,777 | Does long noncoding RNA MALAT1 regulate endothelial cell function and vessel growth? | {
"contexts": [
"The human genome harbors a large number of sequences encoding for RNAs that are not translated but control cellular functions by distinct mechanisms. The expression and function of the longer transcripts namely the long noncoding RNAs in the vasculature are largely unknown.",
"Here, we charac... | Silencing of MALAT1 tips the balance from a proliferative to a migratory endothelial cell phenotype in vitro, and its genetic deletion or pharmacological inhibition reduces vascular growth in vivo. | yes |
24,588,843 | Is the collagen cross-linking enzyme lysyl oxidase associated with the healing of human atherosclerotic lesions? | {
"contexts": [
"Acute clinical complications of atherosclerosis such as myocardial infarction (MI) and ischaemic stroke are usually caused by thrombus formation on the ruptured plaque surface. Collagen, the main structural protein of the fibrous cap, provides mechanical strength to the atherosclerotic plaque. Th... | Lysyl oxidase may contribute to the healing of atherosclerotic lesions and to the prevention of its lethal complications. Mediators of inflammation may control LOX expression in plaques and hence plaque stability. | yes |
24,585,716 | Is mechanical alternans associated with mortality in acute hospitalized heart failure : prospective mechanical alternans study ( MAS )? | {
"contexts": [
"Acute hospitalized heart failure (AHHF) is associated with 40% to 50% risk of death or rehospitalization within 6 months after discharge. Timely (before hospital discharge) risk stratification of patients with AHHF is crucial. We hypothesized that mechanical alternans (MA) and T-wave alternans (T... | MA is independently associated with outcomes in AHHF. | yes |
24,592,079 | Does lipoic acid decrease peritoneal adhesion formation in a rat uterine scar model? | {
"contexts": [
"To investigate the effects of lipoic acid in the prevention of postoperative pelvic adhesions by a visual scoring system and immunohistochemistry in a rat uterine horn model with full thickness injury.",
"Twenty-eight female Wistar albino rats were randomised into four groups: uterine trauma ... | Lipoic acid was found to be effective in reducing postoperative adhesion formation in a rat model. | yes |
24,616,575 | Do cancer stem cell markers correlate with early recurrence and survival in hepatocellular carcinoma? | {
"contexts": [
"To investigate whether expression of cancer stem cell (CSC) markers is associated with recurrence and survival in hepatocellular carcinoma (HCC) patients.",
"A consecutive series of 90 HCC patients who underwent curative hepatectomy between April 2007 and April 2009 were analyzed. Of the 90 p... | Expression of CD133, CD90, and EpCAM CSC markers may be linked to HCC tumor onset and/or progression. In addition, EpCAM expression is associated with shorter survival time, while CD90 expression is associated with early HCC recurrence. | yes |
24,594,442 | Does disc degeneration reduce the delamination strength of the annulus fibrosus in the rabbit annular disc puncture model? | {
"contexts": [
"Degenerative disc disease is a common pathologic disorder accompanied by both structural and biochemical changes. Changes in stress distribution across the disc can lead to annulus fibrosus (AF) damage that can affect the strength and integrity of the disc. Given that some present degeneration th... | The findings of this study suggest that degeneration increases the potential for delamination between AF layers. Given this substantial change to the integrity of the AF after degeneration, clinical treatments should not only target rehydration or regrowth of the NP, but should also target repair and strengthening of t... | yes |
24,586,862 | Does rAGE regulate immune cell infiltration and angiogenesis in choroidal neovascularization? | {
"contexts": [
"RAGE regulates pro-inflammatory responses in diverse cells and tissues. This study has investigated if RAGE plays a role in immune cell mobilization and choroidal neovascular pathology that is associated with the neovascular form of age-related macular degeneration (nvAMD).",
"RAGE null (RAGE... | RAGE-S100B interactions appear to play an important role in CNV lesion formation by regulating pro-inflammatory and angiogenic responses. This study highlights the role of RAGE in inflammation-mediated outer retinal pathology. | yes |
24,594,232 | Is routine post-operative intensive care necessary for children with obstructive sleep apnea at high risk after adenotonsillectomy? | {
"contexts": [
"Post-operative respiratory adverse events (AE) are frequent in children having adenotonsillectomy (AT) for obstructive sleep apnea (OSA). Many hospitals have a policy of routine admission to the intensive care unit (ICU) after surgery for children at highest risk. We aimed to determine the freque... | Our data confirm high rates of AE after AT for high risk patients, however, only 8% suffered a severe AE truly necessitating care in ICU. This outcome was very unlikely if an AE did not occur in PACU. We therefore conclude that routine post-operative ICU care for high risk children may be avoided if prolonged monitorin... | no |
24,588,965 | Does the brain-enriched microRNA miR-124 in plasma predict neurological outcome after cardiac arrest? | {
"contexts": [
"Early prognostication after successful cardiopulmonary resuscitation is difficult, and there is a need for novel methods to estimate the extent of brain injury and predict outcome. In this study, we evaluated the impact of the cardiac arrest syndrome on the plasma levels of selected tissue-specif... | The brain-enriched miRNA miR-124 is a promising novel biomarker for prediction of neurological prognosis following cardiac arrest. | yes |
24,612,679 | Does brain-derived neurotrophic factor promote angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells? | {
"contexts": [
"Brain-derived neurotrophic factor (BDNF), a major type of neurotrophins, plays a role in the regulation of synaptic function. Recent studies suggest that BDNF promotes angiogenesis through its specific receptor, tropomyosin-related kinase B (TrkB). However, the detailed mechanisms for this still ... | The present results for the first time demonstrate that BDNF induces NOX-derived ROS generation through activation of p47 phox in a TrkB receptor-dependent manner, which leads to the promotion of angiogenic tube formation possibly via Akt activation. | yes |
24,602,083 | Is motility response to colonic distention increased in postinfectious irritable bowel syndrome ( PI-IBS )? | {
"contexts": [
"Acute intestinal infection leads to persistent intestinal smooth muscle hypercontractility and pain hypersensitivity after resolution of the infection in animal models. We investigated whether postinfectious irritable bowel syndrome (PI-IBS) is associated with abnormalities in phasic contractions... | Patients with PI-IBS have greater colonic hypercontractility than NI-IBS. We speculate that sustained mild mucosal inflammation may cause this colonic irritability. | yes |
24,615,549 | Does granisetron transdermal system improve refractory nausea and vomiting in gastroparesis? | {
"contexts": [
"Symptoms of gastroparesis include nausea and vomiting, which can markedly diminish quality of life. Nausea and vomiting can also make treatment with oral antiemetics problematic.",
"Our aim was to determine whether treatment-resistant nausea and vomiting in patients with gastroparesis improve... | GTP was moderately effective in reducing refractory symptoms of nausea and/or vomiting from gastroparesis in 50% of patients. Mild side effects were reported by 25% of patients. GTP may be an effective treatment for nausea and vomiting in gastroparesis, and further study is warranted. | yes |
24,612,097 | Does activation of N-methyl-D-aspartate receptor glycine site temporally ameliorate neuropsychiatric symptoms of Parkinson 's disease with dementia? | {
"contexts": [
"We have previously found that sarcosine, a glycine transporter I inhibitor, can improve the psychiatric symptoms of schizophrenia. In this study, we aimed to investigate whether the agent can also ameliorate neuropsychiatric symptoms of Parkinson's disease (PD) patients with dementia.",
"An 8... | Sarcosine temporally improved depression and neuropsychiatric symptoms in PD-D patients without exacerbating the motor or cognitive features; the beneficial effects were more prominent in patients with mild-moderate severity. Enhancement of N-methyl-D-aspartate receptor-glycine cascade may lead to a novel path for the ... | yes |
24,593,848 | Is insulin-like growth factor-1 a mediator of age-related decline of bone health status in men? | {
"contexts": [
"The role of insulin-like growth factor-1 (IGF-1) in bone health in men is debatable. This study aimed to determine whether IGF-1 is a mediator in age-related decline of bone health status measured by calcaneal speed of sound (SOS) in Malaysian men.",
"The study recruited 279 Chinese and Malay... | Serum IGF-1 is a partial mediator in the age-related decline of bone health in men as determined by calcaneal ultrasound. A prospective study should be performed to validate this relationship. | yes |
24,602,166 | Does increased paired box transcription factor 8 have a survival function in glioma? | {
"contexts": [
"The molecular basis to overcome therapeutic resistance to treat glioblastoma remains unclear. The anti-apoptotic b cell lymphoma 2 (BCL2) gene is associated with treatment resistance, and is transactivated by the paired box transcription factor 8 (PAX8). In earlier studies, we demonstrated that i... | PAX8 is increased in the majority of glioblastomas and promoted cell survival. Because PAX8 is absent in normal brain tissue, it may be a promising therapeutic target pathway for treating aggressive gliomas. | yes |
24,602,169 | Do urban settings ensure access to services : findings from the immunisation programme in Kampala Uganda? | {
"contexts": [
"Previous studies on vaccination coverage in developing countries focus on individual- and community-level barriers to routine vaccination mostly in rural settings. This paper examines health system barriers to childhood immunisation in urban Kampala Uganda.",
"Mixed methods were employed with... | Complex health system barriers to childhood immunisation still exist in this urban setting; emphasizing that even in urban areas with great physical access, there are hard to reach people. As the rate of urbanization increases especially in sub-Saharan Africa, governments should strengthen health systems to cater for i... | no |
24,617,351 | Do the prevalence of coronary sinus and left circumflex artery overlap in relation to the mitral valve? | {
"contexts": [
"Characterize where the circumflex artery crosses between the coronary sinus and mitral valve in order to minimize the occurrence of coronary compression during percutaneous indirect mitral valve interventions.",
"Treatment of mitral valve regurgitation using an indirect percutaneous approach ... | The prevalence of circumflex overlap between the coronary sinus and mitral valve was common across the sample size. The large variability in anatomy confirms the value of imaging individual patient cardiac anatomy prior to performing indirect percutaneous mitral valve annuloplasty to avoid impairment to the circumflex ... | yes |
24,602,165 | Do microembolic signals predict cerebral ischaemic events in patients with moyamoya disease? | {
"contexts": [
"Recent studies found that microembolic signals (MESs) could be detected by transcranial Doppler in patients with moyamoya disease. However, the clinical significance of MESs in moyamoya disease remains unclear. Our aim was to investigate whether the MESs could predict cerebral ischaemic events in... | In patients with moyamoya disease, the presence of MESs is associated with recent ischaemic symptoms and independently predicts cerebral ischaemic events. MES detection may be of potential clinical value in the management of patients with moyamoya disease. | yes |
24,612,203 | Does peer and community influence on the acceptance of premarital sex among Vietnamese adolescents? | {
"contexts": [
"Adolescents in Vietnam have a low level of sexual activity, but this may increase with urbanisation and economic development. The aim of this analysis is to understand trends in correlates of permissive attitudes towards premarital sex among Vietnamese adolescents using an ecological framework.",... | The association of permissive attitudes with community norms and certain socio-demographic variables in conjunction with overarching economic development and urbanisation suggests that premarital sex will likely become increasingly common among Vietnamese adolescents. These trends should be further assessed as adolesce... | yes |
24,589,830 | Is management of systolic blood pressure after endoscopic submucosal dissection crucial for prevention of post-ESD gastric bleeding? | {
"contexts": [
"Endoscopic submucosal dissection (ESD) is a useful technique for early gastric neoplasms without lymph node metastasis. However, a critical complication is unpredictable post-ESD bleeding. Some risk factors for post-ESD bleeding have been reported previously, although those risk factors have not ... | Control of SBP after ESD is important for the prevention of post-ESD bleeding because hypertension as a comorbidity, which is associated positively with SBP after ESD, is a significant risk factor for post-ESD bleeding. | yes |
24,588,210 | Does transfusion of older stored blood worsen outcomes in canines depending on the presence and severity of pneumonia? | {
"contexts": [
"In experimental pneumonia we found that transfused older blood increased mortality and lung injury that was associated with increased in vivo hemolysis and elevated plasma cell-free hemoglobin (CFH), non-transferrin-bound iron (NTBI), and plasma labile iron (PLI) levels. In this study, we additio... | The augmented in vivo hemolysis of transfused older red blood cells (RBCs) appears to result in excess plasma CFH and iron release, which requires the presence of established infection to worsen outcome. These data suggest that transfused older RBCs increase the risks from infection in septic subjects. | yes |
24,604,240 | Does intraperitoneal administration of fetuin-A attenuate D-galactosamine/lipopolysaccharide-induced liver failure in mouse? | {
"contexts": [
"Fulminant hepatic failure (FHF) is a devastating syndrome, which sometimes results in death or liver transplantation, in which inflammation would aggravate the development of fetuin-A which would act as an anti-inflammatory factor and may be an available approach to attenuate FHF.",
"The purp... | An intraperitoneal injection of fetuin-A attenuates D-GalN/LPS-induced FHF in mice. Fetuin-A might be a protective agent of liver damage partly through inhibiting liver inflammatory response and hepatocyte apoptosis. | yes |
24,613,612 | Do initial injury severity and social factors determine ability to deploy after combat-related amputation? | {
"contexts": [
"While many recent publications have examined the ability of amputees to return to active duty, it remains largely unknown why few amputees deploy after amputation and many amputees do not. The purpose of this study is to examine what predictor(s) exist for whether or not an amputee will deploy af... | The vast majority of amputees do not able to deploy after undergoing amputation. The main predictors of deploying after sustaining a combat-related amputation appear to be: sustaining a transtibial amputation, being of senior rank or age and being a member of the Special Forces. Many of these factors appear to be non-t... | yes |
24,588,082 | Does tLR4 contribute to the host response to Klebsiella intraocular infection? | {
"contexts": [
"Klebsiella pneumoniae causes a blinding infection called endogenous endophthalmitis. The role of innate immune recognition of K. pneumoniae in the eye during infection is not known. We hypothesized that intraocular recognition of K. pneumoniae was mediated by Toll-like receptor (TLR)-4 and may be... | These studies suggest that TLR4 is important in the early intraocular recognition and host response to K. pneumoniae. However, the role of MagA in TLR4-mediated intraocular recognition and subsequent inflammation is less clear. | yes |
24,602,263 | Do type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE ( 2 ) M17 human neuroblastoma cells? | {
"contexts": [
"Hypoxic-ischaemic injuries such as stroke and traumatic brain injury exhibit features of a distinct neuro-inflammatory response in the hours and days post-injury. Microglial activation, elevated pro-inflammatory cytokines and macrophage infiltration contribute to core tissue damage and contribute... | This study confirms a role for type-1 IFN signalling in the neuro-inflammatory response following OGD in vitro and suggests its modulation through therapeutic blockade of IFNAR1 may be beneficial in reducing hypoxia-induced neuro-inflammation. | yes |
24,588,324 | Is tERT promoter mutation uncommon in acral lentiginous melanoma? | {
"contexts": [
"Melanoma is a heterogeneous group of diseases with distinct sets of genetic changes. Recurrent and mutually exclusive C>T or CC>TT transition mutations were identified in the promoter region of the reverse transcriptase catalytic subunit of the telomerase gene (TERT) in melanoma recently, and it ... | The rarity of TERT promoter mutation in the acral lentiginous melanoma was consistent with the supposed role of UV light in the melanoma pathogenesis and also corroborated the view that acral lentiginous melanomas have a different pathogenesis with the melanomas from sun-exposed sites. | yes |
24,615,685 | Is cD44 variant 6 associated with prostate cancer metastasis and chemo-/radioresistance? | {
"contexts": [
"Prostate cancer (CaP) is the second leading malignancy in older men in Western countries. The role of CD44 variant 6 (CD44v6) in CaP progression and therapeutic resistance is still uncertain. Here, we investigated the roles of CD44v6 in CaP metastasis and chemo/radioresistance. Expression of CD44... | Our findings demonstrate that CD44v6 is an important cancer stem cell-like marker associated with CaP proliferation, invasion, adhesion, metastasis, chemo-/radioresistance, and the induction of EMT as well as the activation PI3K/Akt/mTOR and Wnt signaling pathways, suggesting that CD44v6 is a novel therapeutic target t... | yes |
24,603,989 | Does exogenous hydrogen sulfide ( H2S ) protect alveolar growth in experimental O2-induced neonatal lung injury? | {
"contexts": [
"Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, remains a major health problem. BPD is characterized by impaired alveolar development and complicated by pulmonary hypertension (PHT). Currently there is no specific treatment for BPD. Hydrogen sulfide (H2S), carbon monoxi... | H2S protects from impaired alveolar growth and PHT in experimental O2-induced lung injury. H2S warrants further investigation as a new therapeutic target for alveolar damage and PHT. | yes |
24,598,787 | Does chlorogenic acid inhibit human platelet activation and thrombus formation? | {
"contexts": [
"Chlorogenic acid is a potent phenolic antioxidant. However, its effect on platelet aggregation, a critical factor in arterial thrombosis, remains unclear. Consequently, chlorogenic acid-action mechanisms in preventing platelet activation and thrombus formation were examined.",
"Chlorogenic ac... | Antiplatelet and antithrombotic effects of chlorogenic acid are associated with the A2A receptor/adenylate cyclase/cAMP/PKA signaling pathway. | yes |
24,596,361 | Does human epidermal growth factor receptor-2 positivity predict locoregional recurrence in patients with T1-T2 breast cancer? | {
"contexts": [
"To determine the impact of biological subtypes defined by hormonal receptors and human epidermal growth factor receptor-2 status on risk of recurrence in women with invasive breast cancer treated with breast-conserving therapy.",
"Between 2001-2005, we observed 590 women with invasive breast ... | Patients with hormone receptor-negative or human epidermal growth factor receptor-2-positive T1-T2 breast cancer seem to have a greater risk of disease recurrence. | yes |
24,594,999 | Do tAp63 suppress metastasis via miR-133b in colon cancer cells? | {
"contexts": [
"TAp63 is a tumour-suppressor protein that is often underexpressed in various types of cancer. It has been shown to activate gene transcription depending on the transcription domain and to be closely related with metastasis. In this study, we demonstrate that TAp63 suppresses metastasis in colon c... | TAp63 and microRNA-133b were able to suppress the metastasis of colon cancer. Both TAp63 and microRNA-133b may be potential biomarkers for diagnosis in colon cancer metastasis and may provide unique therapeutic targets for this common malignancy. | yes |
24,594,997 | Is tumoral CD105 a novel independent prognostic marker for prognosis in clear-cell renal cell carcinoma? | {
"contexts": [
"Angiogenesis is essential for tumour growth and metastasis. There are conflicting reports as to whether microvessel density (MVD) using the endothelial marker CD105 (cluster of differentiation molecule 105) in clear-cell renal cell carcinomas (ccRCC) is associated with prognosis. Recently, CD105 ... | We have shown for the first time that tumoral CD105 is an independent predictive marker for death risk and unfavourable prognosis in patients with ccRCC after curative resection. | yes |
24,590,339 | Is a new measurement method in Graf technique : prediction of future acetabular development possible in physiologically immature hips? | {
"contexts": [
"Universal ultrasound screening has led to overtreatment and higher follow-up rates than are found with clinical examination alone because of high incidence of physiologically immature hips (type IIa) in the first weeks of life. The ability to predict future acetabular development in physiological... | The amount of cartilage mass covering the femoral head, which is a part of the acetabular roof, can therefore provide information about future acetabular development. This paper describes a new method of measurement (the γ-angle) that assesses the extent of the cartilage coverage of the femoral head, which can predict ... | yes |
24,593,017 | Is skin irritability to sodium lauryl sulfate associated with increased positive patch test reactions? | {
"contexts": [
"As previous observations have indicated an inter-relationship between irritant and allergic skin reactions we analysed data of synchronous allergen and sodium lauryl sulfate (SLS) patch tests in terms of a relationship between SLS responsiveness and allergic patch test reactions.",
"To analys... | The marked association between SLS reactivity and the number of positive reactions in patch test patients may be due to nonspecific increased skin reactivity at the moment of patch testing only. However, increased SLS reactivity could also be due to longer-lasting enhanced skin irritability, which may have promoted (po... | yes |
24,595,538 | Is dual antiplatelet therapy plus postoperative heparin and dextran safe and effective for reducing risk of embolic stroke during aneurysm coiling? | {
"contexts": [
"Thromboembolic events represent a clinically significant cause of neurological morbidity during the endovascular management of cerebral aneurysms. We have implemented an anti-thromboembolic regimen consisting of pre- and postoperative dual antiplatelet therapy, as well as postoperative anticoagul... | This study provides evidence that the regimen described here is safe and reduces thromboembolic complications during elective aneurysm coiling. Ours is likely the most aggressive regimen in the published literature and significantly reduced the rate of thromboembolism without any significant increase hemorrhagic compli... | yes |
24,585,942 | Does weekend compared with weekday presentation affect outcomes of patients presenting with non-ST elevation acute coronary syndrome? | {
"contexts": [
"In non-ST elevation acute coronary syndromes (NSTEACS), early invasive management improves survival. However, since treatment strategies are urgent, not emergent, decisions to postpone invasive management due to weekend admission could affect outcome.",
"Using the Alberta Provincial Project f... | In a large unselected population of NSTEACS patients, weekend admission was associated with modest delays (4.8 h) in time to catheterization, but not with increased 30-day or 1-year mortality. | no |
24,592,393 | Is p-cresyl sulfate a valuable predictor of clinical outcomes in pre-ESRD patients? | {
"contexts": [
"Previous studies have reported p-cresyl sulfate (PCS) was related to endothelial dysfunction and adverse clinical effect. We investigate the adverse effects of PCS on clinical outcomes in a chronic kidney disease (CKD) cohort study.",
"72 predialysis patients were enrolled from a single medic... | Our study shows serum PCS could be a valuable marker in predicting cardiovascular event and renal function progression in CKD patients without dialysis. | yes |
24,600,531 | Does surgical time of day affect outcome following hip fracture fixation? | {
"contexts": [
"Due to the need for medical optimization and congested operating room schedules, surgical repair is often performed at night. Studies have shown that work done at night increases complications. The primary aim of our study is to compare the rates of complications and 30-day mortality between 2 su... | Surgical time of day did not affect 30-day mortality or total number of complications. Age, ASA score, and CCI were associated with adverse outcomes. | no |
24,606,854 | Does microRNA-223 enhance radiation sensitivity of U87MG cells in vitro and in vivo by targeting ataxia telangiectasia mutated? | {
"contexts": [
"Ataxia telangiectasia mutated (ATM) protein is important in the DNA damage response because it repairs radiation-induced damage in cancers. We examined the effect of microRNA-223 (miR-223), a regulator of ATM expression, on radiation sensitivity of cancer cells.",
"Human embryonic kidney 293 ... | miR-223 overexpression downregulates ATM expression and sensitizes U87 cells to radiation in vitro and in vivo. MicroRNA-223 may be a novel cancer-targeting therapy, although its cancer- and patient-specific roles are currently undefined. | yes |
24,590,678 | Does tetanus toxin preserve skeletal muscle contractile force and size during limb immobilization? | {
"contexts": [
"We examined the possibility that tetanus toxin can prevent muscle atrophy associated with limb immobility in rats.",
"While the knee and ankle joints were immobilized unilaterally, the tibialis anterior (TA) muscle on the immobilized side was injected with 1 μl saline or with 1 ng tetanus tox... | Tetanus toxin prevented common signs of muscle atrophy and may become a useful adjunct to current rehabilitation strategies. | yes |
24,590,208 | Do smad3-deficient mice have reduced esophageal fibrosis and angiogenesis in a model of egg-induced eosinophilic esophagitis? | {
"contexts": [
"Eosinophilic esophagitis (EoE) is a food-triggered disease associated with esophageal fibrosis and stricture formation in a subset of patients. In the present study we used a murine model of egg (ovalbumin [OVA])-induced EoE to determine whether inhibiting transforming growth factor-β1 (TGF-β1) s... | In a mouse model of egg-induced EoE, Smad3-deficient mice have significantly less esophageal remodeling, especially fibrosis and angiogenesis that is associated with reduced expression of VEGF. Targeting the TGF-β1/Smad3 pathway may be a novel strategy to reduce esophageal fibrosis and its associated complications such... | yes |
24,589,771 | Does nADPH oxidase inhibition improve neurological outcome in experimental traumatic brain injury? | {
"contexts": [
"Traumatic brain injury (TBI) is a worldwide health problem with oxidative stress recognized as a major pathogenetic factor. The present experimental study was designed to explore the neuroprotective effect of NADPH oxidase (NOX) inhibitor, apocynin, on mouse TBI.",
"Moderately severe weight-d... | Pre-treatment with apocynin effectively attenuates markers of cerebral oxidative stress after TBI, thus supporting the hypothesis that apocynin is a potential neuroprotectant and adjunct therapy for TBI patients. | yes |
24,612,681 | Does bruton tyrosine kinase mediate TLR9-dependent human dendritic cell activation? | {
"contexts": [
"Bruton tyrosine kinase (BTK) plays an essential role in various biologic functions of different cell types. Mutations in BTK lead to X-linked agammaglobulinemia (XLA) in humans. BTK was recently linked to the innate immune system, in particular, the Toll-like receptor (TLR) pathway; however, the ... | Analysis of these data suggests that BTK regulates human DC responses upon TLR9 engagement in terms of activation, cytokine production, and STAT1/3 upregulation. These findings may be of important significance for better understanding and managing different clinical conditions, such as agammaglobulinemia and lymphoid m... | yes |
24,612,682 | Do children with asthma by school age display aberrant immune responses to pathogenic airway bacteria as infants? | {
"contexts": [
"Asthma is a highly prevalent chronic lung disease that commonly originates in early childhood. Colonization of neonatal airways with the pathogenic bacterial strains Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae is associated with increased risk of later childhood as... | Children with asthma by school age exhibited an aberrant immune response to pathogenic bacteria in infancy. We propose that an abnormal immune response to pathogenic bacteria colonizing the airways in early life might lead to chronic airway inflammation and childhood asthma. | yes |
24,606,089 | Is the metabolically healthy but obese phenotype associated with lower plasma levels of persistent organic pollutants as compared to the metabolically abnormal obese phenotype? | {
"contexts": [
"Although obesity is strongly linked to insulin resistance and type 2 diabetes, a subset of obese individuals termed metabolically healthy but obese (MHO) appears relatively protected from the development of cardiometabolic complications. The origins of this metabolically healthy phenotype remain ... | Our study demonstrates that the metabolically healthy and abnormal phenotypes have distinct plasma POP profiles. | yes |
24,598,002 | Does the nucleotide-binding oligomerization domain-containing protein 1 ( NOD1 ) polymorphism S7N affect receptor function? | {
"contexts": [
"Activation and signal transduction in the Nucleotide binding, leucine-rich repeat containing receptor (NLR) family needs to be tightly regulated in order to control the inflammatory response to exogenous and endogenous danger signals. Phosphorylation is a common cellular mechanism of regulation t... | The NOD1 polymorphism S7N does not interfere with receptor function in response to ligand stimulation. | no |
24,615,981 | Is hCV genotype 3 associated with an increased risk of cirrhosis and hepatocellular cancer in a national sample of U.S. Veterans with HCV? | {
"contexts": [
"Data show that viral genotype 1 may increase the risk of cirrhosis and hepatocellular carcinoma (HCC) compared to genotype 2 in patients with chronic hepatitis C virus (HCV) infection. However, the effect of HCV genotype 3 on cirrhosis and HCC risk is uncertain. We identified patients with active... | HCV genotype 3 is associated with a significantly increased risk of developing cirrhosis and HCC compared to HCV genotype 1. This association is independent of patients' age, diabetes, body mass index, or antiviral treatment. | yes |
24,613,692 | Is lower extremity autologous vein bypass for critical limb ischemia adversely affected by prior endovascular procedure? | {
"contexts": [
"It has been reported that a failed endovascular intervention adversely affects results of lower extremity bypass (LEB). We reviewed rates of prior endovascular intervention (PEI) in patients undergoing LEB with autologous vein for critical limb ischemia (CLI) to determine effects on graft patency... | Overall operative mortality, patency rates, and limb salvage for autologous vein LEB in CLI patients continue to be excellent in the endovascular era and are not necessarily affected by a prior ipsilateral endovascular procedure. Long-term survival remains poor in CLI patients requiring LEB. | no |
24,587,567 | Are cytokine polymorphisms associated with poor sleep maintenance in adults living with human immunodeficiency virus/acquired immunodeficiency syndrome? | {
"contexts": [
"Cytokine activity and polymorphisms have been associated with sleep outcomes in prior animal and human research. The purpose of this study was to determine whether circulating plasma cytokines and cytokine polymorphisms are associated with the poor sleep maintenance commonly experienced by adults... | This study strengthens the evidence for an association between inflammation and sleep maintenance problems. In this chronic illness population, cytokine polymorphisms associated with wake after sleep onset provide direction for intervention research aimed at comparing anti-inflammatory mechanisms with hypnotic agents f... | yes |
24,587,306 | Are death receptor ( DR4 ) haplotypes associated with increased susceptibility of gallbladder carcinoma in north Indian population? | {
"contexts": [
"Defective apoptosis is a hallmark of cancer development and progression. Death receptors (DR4, FAS) and their ligands (TRAIL, FASL) are thought to mediate the major extrinsic apoptotic pathway in the cell. SNPs in these genes may lead to defective apoptosis. Hence, the present study aimed to inve... | The DR4 haplotype C rs20575 A rs20576 A rs6557634 represents an important factor accounting the patients susceptibility to GBC probably due to decreased apoptosis. However, additional well-designed studies with larger sample size focusing on different ethnicities are required to further validate the results. | yes |
24,601,713 | Is vitamin D deficiency at 16 to 20 weeks ' gestation associated with impaired lung function and asthma at 6 years of age? | {
"contexts": [
"Vitamin D deficiency is associated with chronic lung disease. We have previously shown in an in vivo mouse model that maternal vitamin D deficiency is associated with alterations in early life lung structure and function. However, there are limited data to support a relationship between maternal ... | This study supports the notion that vitamin D deficiency during lung development may impact on postnatal lung growth and increase the risk of developing lung disease. | yes |
24,604,630 | Does metformin decrease glycated albumin to glycated haemoglobin ratio in patients with newly diagnosed type 2 diabetes? | {
"contexts": [
"To know whether metformin improves postprandial hyperglycaemia, we examined the effect of metformin on the glycated albumin (GA) to glycated haemoglobin (HbA1c) ratio (GA/HbA1c ratio) in patients with newly diagnosed type 2 diabetes.",
"Metformin and lifestyle interventions were initiated in ... | Metformin decreased the GA/HbA1c ratio in patients with newly diagnosed type 2 diabetes. This suggests that metformin improves postprandial hyperglycaemia in patients with newly diagnosed type 2 diabetes. | yes |
24,607,776 | Does endothelin-1 but not angiotensin II contribute to functional aging in murine carotid arteries? | {
"contexts": [
"Aging is a major risk factor for carotid artery disease and stroke. Endothelin-1 (ET-1) and angiotensin II (Ang II) are important modifiers of vascular disease, partly through increased activity of NADPH oxidase and vasoconstrictor prostanoids. Since the renin-angiotensin and endothelin systems b... | Aging in carotid arteries decreases ETA receptor gene expression and responsiveness to ET-1, which nevertheless becomes increasingly dependent upon NAPDH oxidase activity with age; responses to Ang II and gene expression of its receptors are however unaffected. These findings suggest that physiological aging differenti... | yes |
24,589,236 | Does peptide deformylase inhibitor actinonin reduce celastrol 's HSP70 induction while synergizing proliferation inhibition in tumor cells? | {
"contexts": [
"Celastrol is a promising anti-tumor agent, yet it also elevates heat shock proteins (HSPs), especially HSP70, this effect believed to reduce its anti-tumor effects. Concurrent use of siRNA to increase celastrol's anti-tumor effects through HSP70 interference has been reported, but because siRNA t... | Concurrent use of the chemical agent actinonin could reduce celastrol's HSP70 elevation and also enhance proliferation inhibition by celastrol. This combination presents a novel alternative to siRNA technology and is worth further investigation for its potentially effective anti-tumor action. | yes |
24,585,721 | Does addition of zoledronic acid to neoadjuvant chemotherapy enhance tumor response in patients with HER2-negative stage II/III breast cancer : the NEOZOTAC trial ( BOOG 2010-01 )? | {
"contexts": [
"The role of zoledronic acid (ZA) when added to the neoadjuvant treatment of breast cancer (BC) in enhancing the clinical and pathological response of tumors is unclear. The effect of ZA on the antitumor effect of neoadjuvant chemotherapy has not prospectively been studied before.",
"NEOZOTAC ... | Addition of ZA to neoadjuvant chemotherapy did not improve pathological or clinical response to chemotherapy. Further investigations are warranted in postmenopausal women with BC, since this subgroup might benefit from ZA treatment. | no |
24,589,605 | Does [ GM6001 suppress scar formation after glaucoma filtration surgery in rabbits ]? | {
"contexts": [
"To study the effect of matrix metalloproteinases inhibitor GM6001 in suppressing scar tissue formation in the filtering passage after glaucoma filtration surgery.",
"Twenty-four pigmented rabbits (48 eyes) underwent trabeculectomy followed by subconjunctival injection of GM6001 in the right e... | GM6001 can inhibit excessive proliferation of the fibroblasts in the filtering pathway to suppress scar tissue formation and prolong the existence of the functional filtration bleb in rabbits. | yes |
24,603,133 | Is pPARγ-induced stimulation of amiloride-sensitive sodium current in renal collecting duct principal cells serum and insulin dependent? | {
"contexts": [
"Thiazolidinediones (TZDs), such as rosiglitazone or pioglitazone, are peroxisome proliferator-activated receptor gamma (PPARγ) agonists currently used in the treatment of type 2 diabetes. However, their clinical applicability is limited by common and severe side effects including strong water ret... | Our data show an increase in transepithelial sodium amiloride-sensitive current induced by a PPARγ agonist in presence of serum and insulin, thus confirming some in-vitro and in-vivo experiments while providing explanations for previous conflicting findings. | yes |
24,598,784 | Does the association of telomere length with colorectal cancer differ by the age of cancer onset? | {
"contexts": [
"Telomeres are nucleoprotein structures that cap the end of chromosomes and shorten with sequential cell divisions in normal aging. Short telomeres are also implicated in the incidence of many cancers, but the evidence is not conclusive for colorectal cancer (CRC). Therefore, the aim of this study... | Younger individuals with longer telomeres or older individuals with shorter telomeres are at higher risk for CRC. These findings indicate that the association of PBL telomere length varies according to the age of cancer onset and that CRC is likely associated with at minimum two different mechanisms of telomere dynamic... | yes |
24,604,529 | Does spouse confidence in self-efficacy for arthritis management predict improved patient health? | {
"contexts": [
"In addition to patient self-efficacy, spouse confidence in patient efficacy may also independently predict patient health outcomes. However, the potential influence of spouse confidence has received little research attention.",
"The current study examined the influence of patient and spouse e... | Our findings add to a growing literature that highlights the important role of spouse perceptions in patients' long-term health. | yes |
24,589,090 | Does preoperative immunonutrition decrease postoperative complications by modulating prostaglandin E2 production and T-cell differentiation in patients undergoing pancreatoduodenectomy? | {
"contexts": [
"An immune-enhancing diet has been used to alter eicosanoid synthesis, cytokine production, and immune function in an attempt to limit the undesired immune reactions after injury from surgery. This prospective randomized study was designed to investigate the effect of preoperative immunonutrition ... | Preoperative immunonutrition modulates PGE2 production and T-cell differentiation and may protect against the aggravation of operative complications in patients undergoing pancreatoduodenectomy. | yes |
24,586,872 | Does blockade of the programmed death-1 ( PD1 ) pathway undermine potent genetic protection from type 1 diabetes? | {
"contexts": [
"Inhibition of PD1-PDL1 signaling in NOD mice accelerates onset of type 1 diabetes implicating this pathway in suppressing the emergence of pancreatic beta cell reactive T-cells. However, the molecular mechanism by which PD1 signaling protects from type 1 diabetes is not clear. We hypothesized tha... | These results indicate that multiple Idd loci collaborate with PD1 signaling. Anti PDL1 treatment undermines a large portion of the genetic protection mediated by Idd genes in the NOD model of type 1 diabetes. Basal insulitis correlated with higher susceptibility to type 1 diabetes. These findings have important implic... | yes |
24,610,603 | Is liquid paraffin superior to 2 % lidocaine gel in reducing urethral pain during urodynamic study in men : A pilot study? | {
"contexts": [
"To compare the pain perception between intraurethral instillation of 2% lidocaine gel and liquid paraffin during Urodynamic study in men.",
"A randomized, single-blind comparison trial was conducted. Forty men scheduled to undergo multichannel Urodynamic study were randomized to receive eithe... | Liquid paraffin is more efficient than 2% lidocaine gel in reducing urethral pain during Urodynamic study in men. Pain scores were specifically better during the instillation of the lubricant and during the delivery of the urethral catheter. | yes |
24,611,954 | Does fish oil supplementation increase concentration of adiponectin in healthy dogs? | {
"contexts": [
"To determine the effect of fish oil supplementation on circulating concentrations of adiponectin, leptin, insulin, glucose, triglyceride and cholesterol in healthy dogs.",
"Twenty healthy adult dogs were administered 220 mg/kg of a fish oil supplement once daily for 30 days. At baseline, on s... | Fish oil supplementation significantly increased circulating concentration of adiponectin in healthy non-obese dogs. Further investigation is warranted to determine whether this effect may be extended to obese dogs and to evaluate the potential role of fish oil supplementation in the management of disorders associated ... | yes |
24,590,656 | Is cO ( 2 ) concentration in day care centres related to wheezing in attending children? | {
"contexts": [
"Poor ventilation at day care centres (DCCs) was already reported, although its effects on attending children are not clear. This study aimed to evaluate the association between wheezing in children and indoor CO2 (a ventilation surrogate marker) in DCC and to identify behaviours and building char... | Improved ventilation is needed to achieve a healthier indoor environment in DCC. | yes |
24,602,711 | Do nBME subject examination in surgery scores correlate with surgery clerkship clinical experience? | {
"contexts": [
"Most medical schools in the United States use the National Board of Medical Examiners Subject Examinations as a method of at least partial assessment of student performance, yet there is still uncertainty of how well these examination scores correlate with clinical proficiency. Thus, we investiga... | Students experiencing higher clinical volumes on surgical services, but less self-study time demonstrated statistically higher academic performance on objective evaluation, suggesting clinical experience may be of higher value than self-study and reading. | yes |
24,612,108 | Does warm temperature stimulus suppress the perception of skin wetness during initial contact with a wet surface? | {
"contexts": [
"In the absence of humidity receptors in human skin, the perception of skin wetness is considered a somatosensory experience resulting from the integration of temperature (particularly cold) and mechanical inputs. However, limited data are available on the role of the temperature sense.",
"Wet... | We conclude that it is not the contact of the skin with moisture per se, but rather the integration of particular sensory inputs (amongst which coldness seems dominant) which drives the perception of skin wetness during the initial contact with a wet surface. | yes |
24,613,271 | Does comprehensive care improve physical recovery of hip-fractured elderly Taiwanese patients with poor nutritional status? | {
"contexts": [
"The effects of nutritional management among other intervention components have not been examined for hip-fractured elderly persons with poor nutritional status. Accordingly, this study explored the intervention effects of an in-home program using a comprehensive care model that included a nutriti... | An in-home program using the comprehensive care model with a nutritional component effectively improved the nutritional status of hip-fractured patients with poor nutrition. This comprehensive care intervention more effectively improved recovery of functional independence and balance for patients with recovered nutriti... | yes |
24,613,274 | Does swietenia macrophylla King induce mitochondrial-mediated apoptosis through p53 upregulation in HCT116 colorectal carcinoma cells? | {
"contexts": [
"Swietenia macrophylla King is a traditional herb used to treat various diseases including hypertension, diabetes and cancer. Previous study demonstrated its anti-tumor effect but the potential mechanisms have not been clearly defined. The current study was to further investigate the underlying me... | These results suggested that SMEAF exerts its antitumor activity in HCT116 cells by activating proapoptotic signaling pathway through intracellular ROS formation triggering the mitochondrial-mediated pathway via p53 activation. | yes |
24,593,856 | Are subclinical myocardial inflammation and diffuse fibrosis common in systemic sclerosis -- a clinical study using myocardial T1-mapping and extracellular volume quantification? | {
"contexts": [
"Systemic sclerosis (SSc) is characterised by multi-organ tissue fibrosis including the myocardium. Diffuse myocardial fibrosis can be detected non-invasively by T1 and extracellular volume (ECV) quantification, while focal myocardial inflammation and fibrosis may be detected by T2-weighted and la... | Cardiac involvement is common in SSc even in the absence of cardiac symptoms, and includes chronic myocardial inflammation as well as focal and diffuse myocardial fibrosis. Myocardial abnormalities detected on CMR were associated with impaired strain parameters, as well as disease activity and severity in SSc patients.... | yes |
24,599,164 | Does maze surgery normalize left ventricular function in patients with persistent lone atrial fibrillation? | {
"contexts": [
"The aim of this study is to evaluate the mid-term clinical and functional outcomes of maze surgery in symptomatic refractory lone atrial fibrillation (AF) patients.",
"Between March 2008 and January 2013, 39 highly symptomatic patients [mean age 51 ± 10 (mean ± standard deviation); 95% CI, Eu... | Within a dedicated AF centre, maze surgery grants excellent outcomes, with symptoms relief and negligible risk. It provides a complete reversal of arrhythmia-related myocardial dysfunction and is therefore a convenient alternative to His bundle ablation and lifelong pacemaker dependency in symptomatic refractory patien... | yes |
24,600,976 | Is hepatic impairment induced by scrub typhus associated with new onset of renal dysfunction? | {
"contexts": [
"Scrub typhus is a potentially fatal infectious disease caused by Orientia tsutsugamushi. There is little attention given to hepatic impairment in the adults with scrub typhus. This study investigated the incidence and the prognostic implications of hepatic impairment in patients with scrub typhus... | The degree of hepatic impairment induced by scrub typhus is associated with new onset of renal dysfunction. | yes |
24,608,456 | Is the expression of disabled-2 common reduced in meningiomas? | {
"contexts": [
"Disabled-2 (Dab2) is frequently down-regulated in several types of cancers. We examined the expression level of Dab2 in human meningiomas and meningioma cells, aimed to investigate its role in the oncogenesis and development of meningiomas.",
"Western blot analysis was employed to detect Dab2... | Dab2 is expressed at variable level in meningiomas with different grade of malignancy and probably plays a pivotal role in the early stage of oncogenesis of malignant meningiomas. | yes |
24,605,682 | Does [ New approach to detection of legionellosis causative agents in clinical samples and environment objects by PCR ]? | {
"contexts": [
"Selection of perspective targets as a base for development of test systems for the detection of legionella DNA in study material by PCR with electrophoresis and hybridization-fluorescent accounting of the results.",
"22 Legionella pneumophila, 3 Legionella spp. strains and 30 cultures ofheter... | The studies carried out have shown the perspective of use of life-support ftsZ and mompS genes for the construction of novel preparations for legionellosis genetic diagnostics. | yes |
24,613,046 | Is expression of toll-like receptor 2 and 4 increased in the respiratory epithelial cells of chronic idiopathic interstitial pneumonia patients? | {
"contexts": [
"Idiopathic interstitial pneumonia (IIP) is characterized by chronic interstitial inflammation and fibrosis. Although mounting evidence has suggested that toll-like receptor (TLR) 2 and TLR4 are involved in the pathogenesis of non-infectious lung injury in vitro and in mouse models, their roles in... | This study demonstrates that RE cells over-express TLR2 and TLR4 in the lungs of IIP patients. These findings suggest that high expression of TLRs may contribute to the pathogenesis of human IIP. | yes |
24,588,892 | Are dermoscopic features of cutaneous melanoma associated with clinical characteristics of patients and tumours and with MC1R genotype? | {
"contexts": [
"Several algorithms are available for the dermoscopic diagnosis of pigmented skin lesions. The MC1R gene is a key determinant of pigmentation characteristics that are established host-related melanoma risk factors.",
"To investigate the association of dermoscopic features of sporadic cutaneous... | We suggest a phenotypic/MC1R profile for melanoma patients and their tumours. Melanomas of MC1R R carriers show a significant lower TDS value, with reduced dermoscopic structures, and a lower prevalence of an atypical pigment network. Non-carriers of MC1R R variants develop melanomas dermoscopically characterized by an... | yes |
24,595,335 | Are measurement errors in polymerase chain reaction a confounding factor for a correct interpretation of 5-HTTLPR polymorphism effects on lifelong premature ejaculation : a critical analysis of a previously published meta-analysis of six studies? | {
"contexts": [
"To analyze a recently published meta-analysis of six studies on 5-HTTLPR polymorphism and lifelong premature ejaculation (PE).",
"Calculation of fraction observed and expected genotype frequencies and Hardy Weinberg equilibrium (HWE) of cases and controls. LL,SL and SS genotype frequencies of... | In three studies not-in-HWE and with very low OR, inadequate PCR analysis and/or inadequate interpretation of its gel electrophoresis resulted in very low SL and a resulting shift to very high SS genotype frequency outcome. Consequently, PCRs of these three studies are not reliable. Failure to note the inadequacy of PC... | yes |
24,611,741 | Does acute metformin preconditioning confer neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy? | {
"contexts": [
"Recent clinical trials report that metformin, an activator of AMP-activated protein kinase (AMPK) used to treat type 2 diabetes, significantly reduces the risk of stroke by actions that are independent of its glucose-lowering effects. However, the underlying molecular mechanisms are not known. He... | These results provide the first evidence that acute metformin preconditioning induces autophagy by activation of brain AMPK, which confers neuroprotection against subsequent cerebral ischaemia. This suggests that metformin, a well-known hypoglycaemic drug, may have a practical clinical use for stroke prevention. | yes |
24,612,219 | Is hMGA2 down-regulated by microRNA let-7 and associated with epithelial-mesenchymal transition in oesophageal squamous cell carcinomas of Kazakhs? | {
"contexts": [
"To investigate the expression of let-7 and its regulation of high-mobility group A2 protein (HMGA2), and to verify the relationship between let-7, HMGA2 and the process of epithelial-mesenchymal transition (EMT), in oesophageal squamous cell carcinomas (OSCC) of Kazakh patients.",
"Expression... | Expression of let-7 can suppress cell proliferation by acting directly on regulation of HMGA2 in OSCC. High expression of Snail and its correlation with HMGA2 expression and tumour invasion suggest that HMGA2 may be involved in EMT in the OSCC of Kazakh patients. | yes |
24,589,829 | Do serum levels of preoperative α-fetoprotein and CA19-9 predict survival of hepatic carcinoma patients after liver transplantation? | {
"contexts": [
"The aim of this study was to assess serum levels of presurgical α-fetoprotein (AFP) and carbohydrate antigen 19-9 (CA19-9) as prognostic markers in patients with hepatic carcinoma after liver transplantation (LT).",
"A total of 226 patients were recruited for the analysis of serum AFP and CA1... | The data from this study showed that serum levels of preoperative AFP and CA19-9 were able to predict survival of patients with hepatic carcinoma after LT. This study included novel criteria, adding serum AFP and CA19-9 levels to the selection criteria for LT eligibility of patients, in addition to the Milan criteria. | yes |
24,614,337 | Does lifestyle-induced decrease in fat mass improve adiponectin secretion in obese adults? | {
"contexts": [
"Several studies have identified relationships between weight loss and adipokine levels; however, none have looked at the combined effect of aerobic exercise training with the consumption of a low- or a high-glycemic diet. We examined the effects of 12 wk of aerobic exercise combined with either a... | The data suggest that exercise training, independent of dietary glycemic index, favorably alters HMW adiponectin and leptin secretion and that a reduction in visceral fat mass is a key factor regulating HMW adiponectin in older obese persons. | yes |
24,595,189 | Is pericardial fat associated with atrial conduction : the Framingham Heart Study? | {
"contexts": [
"Obesity is associated with altered atrial electrophysiology and a prominent risk factor for atrial fibrillation. Body mass index, the most widely used adiposity measure, has been related to atrial electrical remodeling. We tested the hypothesis that pericardial fat is independently associated wit... | Pericardial fat is associated with atrial conduction as quantified by PWI, even with adjustment for extracardiac fat depots. Further studies are warranted to identify the mechanisms through which pericardial fat may modify atrial electrophysiology and promote subsequent risk for arrhythmogenesis. | yes |
24,597,607 | Do small RNAs in the peripheral blood discriminate metastasized from non-metastasized seminoma? | {
"contexts": [
"We aimed to better discriminate metastasized (lymphogen/occult/both combined) from non-metastasized seminoma based on post-transcriptional changes examined in the peripheral blood.",
"Total RNAs including small RNAs were isolated from the peripheral blood of patients suffering from metastasiz... | Metastasized (either lymphogen or occult) seminoma can be completely discriminated from non-metastasized seminoma with a combination of two small RNAs measured in the peripheral blood. | yes |
24,596,514 | Is prealbumin a more sensitive marker than albumin to assess the nutritional status in patients undergoing radiotherapy for head and neck cancer? | {
"contexts": [
"The aim of this prospective study was to determine the prevalence of malnutrition and to evaluate a more sensitive marker to assess the nutritional status in patients undergoing RT for head and neck cancer.",
"The prospective study included 51 (mean age of 57.6 ±11.2 years) patients undergoin... | The prevalence of malnutrition was high in patients with head and neck cancer. Prealbumin was a more sensitive marker than albumin to assess the nutritional status in these patients. | yes |
24,602,757 | Is not only type 2 diabetes but also prediabetes associated with portal inflammation and fibrosis in patients with non-alcoholic fatty liver disease? | {
"contexts": [
"Growing evidence suggests that not only type 2 diabetes (T2D) but also prediabetes (PD) is common in patients with non-alcoholic fatty liver disease (NAFLD). However, few data exist on how PD impacts the histological characteristics of NAFLD patients. In this exploratory study, we sought to inves... | Not only T2D but also PD is independently associated with portal inflammation and fibrosis in NAFLD patients. PD may be useful as a clinical indicator of patients who are likely to have already more severe histological findings. | yes |
24,607,049 | Is maternal second-hand smoke exposure in pregnancy associated with childhood asthma development? | {
"contexts": [
"Childhood asthma development has been associated with active maternal smoking during pregnancy, but its association with maternal second-hand smoke exposure in pregnancy needs to be evaluated.",
"We investigated longitudinal associations between maternal smoke exposure in pregnancy and childh... | Maternal home second-hand smoke exposure during pregnancy is associated with incident physician-diagnosed childhood asthma, even if the mother does not smoke actively during pregnancy. Childhood asthma prevention programs should include smoking cessation strategies targeted toward smokers who live in the homes of smoki... | yes |
24,607,045 | Does ongoing allergic rhinitis impair asthma control by enhancing the lower airway inflammation? | {
"contexts": [
"The relationship between allergic rhinitis and asthma is well accepted; however, little is known about the mechanism that underlies the interactions between the upper and lower airways.",
"To investigate the symptomatic and inflammatory linkages between allergic rhinitis and asthma in patient... | This observational study of patients with atopy indicates that the ongoing allergic rhinitis is related to worsening of asthma by enhancing the lower airway inflammation. | yes |
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