pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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|---|---|---|---|---|
24,588,805 | Is the mitochondrial ATPase6 gene more susceptible to mutation than the ATPase8 gene in breast cancer patients? | {
"contexts": [
"Breast cancer is the most common malignancy in women throughout the world. Mitochondria play important roles in cellular energy production, free radical generation and apoptosis. Identification of mitochondrial DNA mutations and/or polymorphisms as cancer biomarkers is rapidly developing in molec... | Our results showed that the ATPase6 gene is more susceptible to variations in breast cancer and may play an important role in tumorigenesis by changing the energy metabolism level in cancer cells. | yes |
24,608,370 | Does curcuma longa ( curcumin ) decrease in vivo cisplatin-induced ototoxicity through heme oxygenase-1 induction? | {
"contexts": [
"To investigate whether curcumin may have in vivo protective effects against cisplatin ototoxicity by its direct scavenger activity and/or by curcumin-mediated upregulation of HO-1.",
"Cisplatin-induced ototoxicity is a major dose-limiting side effect in anticancer chemotherapy. A protective a... | This preclinical study demonstrates that systemic curcumin attenuates ototoxicity and provides molecular evidence for a role of HO-1 as an additional mediator in attenuating cisplatin-induced damage. | yes |
24,606,467 | Are pre-treatment metabolic tumor volume and total lesion glycolysis useful prognostic factors for esophageal squamous cell cancer patients? | {
"contexts": [
"To study application of the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) with 18F-FDG PET/CT for predicting prognosis of esophageal squamous cell cancer (ESC) patients.",
"Eighty-six patients with ESC staged from I to IV were prosp... | Pre-treatment MTV and TLG are useful prognostic factors in non- surgical ESC. | yes |
24,606,469 | Is higher Ki67 expression associates with unfavorable prognostic factors and shorter survival in breast cancer? | {
"contexts": [
"The prognostic value of the Ki67 expression level is yet unclear in breast cancer. The aim of this study was to investigate the association between Ki67 expression levels and prognostic factors such as grade, Her2 and hormone receptor expression status in breast cancers.",
"Clinical and patho... | High Ki67 expression is associated with ER negativity, Her2 positivity, higher grade and axillary lymph node involvement in breast cancers. The level of Ki67 expression is a prognostic factor predicting relapse-free and overall survival in breast cancer patients. | yes |
24,587,142 | Are malignant pleural effusion supernatants substitutes for metastatic pleural tumor tissues in EGFR mutation test in patients with advanced lung adenocarcinoma? | {
"contexts": [
"Though the possibility of using malignant pleural effusions (MPEs) as alternatives for metastatic pleural tumor tissues (MPTTs) in epidermal growth factor receptor (EGFR) mutation test has been examined, due to the lack of studies comparing the results in matching MPEs and MPTTs, the clinical val... | The high concordance of EGFR mutation statuses between MPEs and MPTTs in lung adenocarcinoma patients with pleural metastasis as determined by ARMS analysis suggests that MPEs, particularly MPE supernatants, may be substitutes for MPTTs in EGFR mutation test. | yes |
24,590,958 | Are sonic hedgehog-expressing basal cells general post-mitotic precursors of functional taste receptor cells? | {
"contexts": [
"Taste buds contain ∼60 elongate cells and several basal cells. Elongate cells comprise three functional taste cell types: I, glial cells; II, bitter/sweet/umami receptor cells; and III, sour detectors. Although taste cells are continuously renewed, lineage relationships among cell types are ill-d... | Shh+ cells are not stem cells, but are post-mitotic, immediate precursors of taste cells. Shh+ cells differentiate into each of the three taste cell types, and the choice of a specific taste cell fate is regulated to maintain the proper ratio within buds. | yes |
24,613,022 | Are rectal microRNAs perturbed in pediatric inflammatory bowel disease of the colon? | {
"contexts": [
"Changes in intestinal microRNAs have been reported in adult patients with ulcerative colitis or Crohn's disease. The goal of this study was to identify changes in microRNA expression associated with colitis in children with inflammatory bowel disease.",
"Rectal mucosal biopsies (n = 50) and b... | This study has demonstrated that rectal and serum microRNAs are perturbed in pediatric inflammatory bowel disease. Future studies identifying targets of inflammatory bowel disease-associated microRNAs may lead to novel therapies. | yes |
24,584,612 | Do anthropometrics Identify Wasting in Patients Undergoing Surgery for Encapsulating Peritoneal Sclerosis? | {
"contexts": [
"♦",
"Encapsulating peritoneal sclerosis (EPS) is a serious complication of peritoneal dialysis in which gastrointestinal (GI) symptoms reduce appetite and dietary intake. Adequate nutrition is important, especially if surgery is required. Although the incidence of EPS is low, the present repo... | Our findings demonstrate the poor nutrition status of patients admitted for EPS surgical intervention. Anthropometrics reveal depleted fat and lean body mass in EPS patients, which might be a result of anorexia and inflammation, and the reason that albumin was not an accurate marker of nutrition. Poor nutrition status ... | yes |
24,584,618 | Is prognostic value of serum von Willebrand factor , but not soluble ICAM and VCAM , for mortality and cardiovascular events independent of residual renal function in peritoneal dialysis patients? | {
"contexts": [
"We explored associations between markers of endothelial dysfunction and outcome events, and whether those associations were independent of residual renal function (RRF) in patients on peritoneal dialysis.",
"The study enrolled 261 incident patients and 68 healthy control subjects who were fol... | The prognostic value of vWf, but not sICAM, is independent of RRF in predicting mortality and CV events. | yes |
24,584,619 | Does intraperitoneal fluid overestimate hydration status assessment by bioimpedance spectroscopy? | {
"contexts": [
"Bioimpedance spectroscopy (BIS) is a valuable tool to assess nutrition and volume status in peritoneal dialysis (PD) patients. However, data about the influence of intraperitoneal fluid on body composition measures are conflicting, and there is no clear consensus about whether the abdomen should ... | Fluid overload is overestimated by BIS when performed in patients with dialysate in the peritoneum. The observed differences are greater in younger, more poorly nourished, or less overhydrated patients. If more precise results are required, we suggest that the abdomen be drained before BIS is performed. | yes |
24,587,311 | Does urotensin II induce interleukin 8 expression in human umbilical vein endothelial cells? | {
"contexts": [
"Urotensin II (U-II), an 11-amino acid peptide, exerts a wide range of actions in cardiovascular systems. Interleukin-8 (IL-8) is secreted by endothelial cells, thereby enhancing endothelial cell survival, proliferation, and angiogenesis. However, the interrelationship between U-II and IL-8 as wel... | The results show that U-II induces IL-8 expression in human umbilical vein endothelial cells via p38 mitogen-activated protein kinase and extracellular signal-regulated kinase signaling pathways and IL-8 is involved in the U-II-induced proliferation of human umbilical vein endothelial cells. | yes |
24,604,884 | Do resource utilization and end-of-life care in a US hospital following medical emergency team-implemented resuscitate orders? | {
"contexts": [
"Medical emergency teams frequently implement do not resuscitate orders, but little is known about end-of-life care in this population.",
"To examine resource utilization and end-of-life care following medical emergency team-implemented do not resuscitate orders.",
"Retrospective review.",... | Despite high mortality, patients with medical emergency team-implemented do not resuscitate orders had a relatively low utilization of end-of-life resources, including palliative care consultation and home hospice services. Coordinated care between medical emergency teams and inpatient palliative care services may help... | no |
24,604,886 | Does oat-enriched diet reduce inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes? | {
"contexts": [
"Inflammatory status can increase the risk of adverse cardiovascular events linked to platelet activity and involvement of microparticles (MP) released from platelets (PMP), leukocytes (LMP), and monocytes (MMP). These MP carry host cell-derived antigens that may act as markers of metabolic health... | OAT improved risk factors assessed by MP status, even in subjects with type 2 diabetes already well-controlled by diet and life-style alone. | yes |
24,587,313 | Does iL-17 induce an expanded range of downstream genes in reconstituted human epidermis model? | {
"contexts": [
"IL-17 is the defining cytokine of the Th17, Tc17, and γδ T cell populations that plays a critical role in mediating inflammation and autoimmunity. Psoriasis vulgaris is an inflammatory skin disease mediated by Th1 and Th17 cytokines with relevant contributions of IFN-γ, TNF-α, and IL-17. Despite ... | The genes identified in IL-17-treated RHE are likely relevant to the IL-17 effects in psoriasis, since ixekizumab (anti-IL-17A agent) strongly suppressed the "RHE" genes in psoriasis patients treated in vivo with this IL-17 antagonist. | yes |
24,610,897 | Do obese hypertensive men have plasma concentrations of C-reactive protein similar to that of obese normotensive men? | {
"contexts": [
"Low-grade chronic inflammation is a characteristic feature of obesity, the most important lifestyle risk factor for hypertension. Elevated plasma concentrations of the inflammatory biomarker C-reactive protein (CRP) are associated with an increased risk of hypertension, but elevated plasma CRP co... | Obese hypertensive men, matched for anthropometric measurements, have plasma CRP concentrations similar to those of obese normotensive men. | yes |
24,595,201 | Is prevention of arterial stiffening by using low-dose atorvastatin in diabetes associated with decreased malondialdehyde? | {
"contexts": [
"Without affecting the lipid profile, a low-dose treatment with atorvastatin contributes to the reduction of oxidative stress, inflammation, and adverse cardiovascular events in diabetes. In this study, we investigated whether low-dose atorvastatin exerts any beneficial effect on vascular dynamics... | These findings indicate that low-dose atorvastatin might protect diabetic vasculature against diabetes-associated deterioration in aorta stiffness and cardiac hypertrophy, possibly through its decrease of lipid oxidation-derived malondialdehyde. | yes |
24,615,604 | Does hemoglobin level influence tumor response and survival after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma? | {
"contexts": [
"Neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy confers a survival benefit on patients with esophageal cancer. However, nCRT might be less meaningful for poor responders. Thus, being able to predict responses would help ensure the selection of optimal therapy.",
"We reviewed da... | Pretherapeutic hemoglobin levels can influence responses and survival after nCRT for ESCC. Thus, hemoglobin levels can serve as a useful marker for tailoring optimal therapies for individual patients with advanced ESCC. | yes |
24,615,606 | Is extracapsular lymph node involvement associated with colorectal liver metastases and impact outcome after hepatectomy for colorectal metastases? | {
"contexts": [
"Hepatic resection of metastatic colorectal cancer (CRC) has become the treatment of choice for patients after resection of the primary CRC. However, some patients do not benefit from immediate resection because of rapidly progressive disease. The aim of this study was to examine the prognostic va... | In patients with hepatic CRC metastases, ECI in regional LNs reflects a particularly aggressive behavior, such as a greater number of liver metastases. In CRC patients with liver metastases, ECI in regional LNs might be correlated with poor prognosis following liver resection. | yes |
24,587,778 | Is increased expression of SHP-1 associated with local recurrence after radiotherapy in patients with nasopharyngeal carcinoma? | {
"contexts": [
"Nasopharyngeal carcinoma (NPC) is a major cancer in southern China. Src homology phosphatase-1 (SHP-1) is a tyrosine phosphatase that regulates growth, differentiation, cell cycle progression, and oncogenesis. We determined the clinical significance of SHP-1 expression in the tumours of NPC patie... | SHP-1 appears to be associated with radiation resistance of NPC cells and can be considered as a candidate marker for prognosis and/or therapeutic target in patients with this type of cancer. | yes |
24,597,635 | Do examination of spectral timbre cues and musical instrument identification in cochlear implant recipients? | {
"contexts": [
"To investigate the discrimination of two isolated spectral timbre cues, spectral centroid (Fc) and spectral irregularity (spIrr), in cochlear implant (CI) listeners. To examine whether the perception of Fc and spIrr changes is related to the perception of loudness and pitch and the identification... | CI recipients are able to detect small modifications in spectral timbre cues which are in turn associated with changes in loudness and pitch. Variations of spectral centroid have a larger impact on loudness and pitch perception than variations of spectral irregularity. Music listening behaviour prior to onset of deafne... | yes |
24,606,674 | Does career influence among final year dental students who plan to enter private practice? | {
"contexts": [
"Existing research about the influence of educational debt on students' decision to enter general practice immediately after graduation is conflicting. Other potential factors that could affect this decision include the influence of a spouse or other family member, the importance of a mentoring de... | Since the 1970s, increasing numbers of dentists in the U.S. have pursued specialty training after dental school. However, rising educational debts may counter this trend as increasing numbers of dentists choose to immediately pursue general dentistry at graduation. This project has demonstrated the significant influenc... | yes |
24,610,445 | Does transglutaminase 2 inhibitor abrogate renal cell carcinoma in xenograft models? | {
"contexts": [
"To test whether transglutaminase 2 (TGase 2) inhibitor GK921 alone reverses renal cell carcinoma (RCC) tumor growth. RCC is resistant to both radiation and chemotherapy, and the prognosis remains poor. Despite the recent therapeutic success of vascular endothelial growth factor inhibition in RCC,... | TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC. | yes |
24,595,858 | Does the transcription factor CREB have no non-redundant functions in hepatic glucose metabolism in mice? | {
"contexts": [
"Excessive hepatic glucose production is a hallmark of insulin resistance in type 2 diabetes. The cAMP responsive transcription factor cAMP responsive element binding protein (CREB), thought to be a key activator of the hepatic gluconeogenic gene regulation programme, has been suggested as a thera... | Our data show that CREB has no non-redundant functions in hepatic glucose metabolism, and is therefore not likely to be a useful target for the development of glucose-lowering drugs. | yes |
24,604,622 | Is vascular smooth muscle cell apoptosis an early trigger for hypothyroid atherosclerosis? | {
"contexts": [
"Endothelial dysfunction is an initial and vascular smooth muscle cell (VSMC) apoptosis, a later step of atherosclerosis. Hypothyroidism accelerates atherosclerosis. However, the early events responsible for this pro-atherosclerotic effect are unclear.",
"Rats were resistant to induction of at... | These findings provide an in vivo example for VSMC apoptosis as an early trigger of hypothyroidism-associated atherosclerosis, and reveal activation of TRα1 receptors to prevent VSMC apoptosis as a therapeutic strategy in this disease. | yes |
24,602,606 | Does butyrate impair atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation? | {
"contexts": [
"Butyrate is a four-carbon fatty acid that presents anti-inflammatory, anti-oxidative and apoptotic properties in colon and several cell lines. Because atherosclerosis has important oxidative and inflammatory components, butyrate could reduce oxidation and inflammation, impairing atherogenesis. We... | Oral butyrate is able to slow the progression of atherosclerosis by reducing adhesion and migration of macrophages and increasing plaque stability. These actions are linked to the reduction of CD36 in macrophages and endothelial cells, decreased pro-inflammatory cytokines and lower activation of NFκB all of these data ... | yes |
24,602,149 | Does carotid artery elasticity decrease during pregnancy - the Cardiovascular Risk in Young Finns study? | {
"contexts": [
"The aims were to evaluate the effect of pregnancy on carotid artery elasticity and determine the associations between maternal lipids, endothelial function and arterial elasticity during pregnancy.",
"We examined 99 pregnant and 99 matched non-pregnant control women as part of a population-ba... | The present study revealed that carotid artery elasticity declined towards the end of the pregnancy; this neither is straight correlating with maternal hyperlipidemia or the diameter of the carotid artery nor is it associated with changes in endothelial function. | yes |
24,614,510 | Does microtubule disorganization affect the mitochondrial permeability transition pore in cardiac myocytes? | {
"contexts": [
"Microtubule (MT) disorganization is related to cardiac disorders. To elucidate the mechanism by which disorganization of the MT network deteriorates cardiac function, the relationship between MT disorganization and mitochondrial permeability transition pore (mPTP) in cardiac myocytes was investig... | Disruption of the MT network by nocodazole might destroy the MT-mitochondria connection and alter mitochondrial function. MT disorganization by paclitaxel could regulate mPTP through the outer mitochondrial membrane complex and the Ca(2+)-sensitive signaling pathway, which also interacts with the mitochondrial fusion p... | yes |
24,587,680 | Does chloride intracellular channel 1 regulate colon cancer cell migration and invasion through ROS/ERK pathway? | {
"contexts": [
"To investigate the mechanisms of chloride intracellular channel 1 (CLIC1) in the metastasis of colon cancer under hypoxia-reoxygenation (H-R) conditions.",
"Fluorescent probes were used to detect reactive oxygen species (ROS) in LOVO cells. Wound healing assay and transwell assay were perform... | Our results suggest that CLIC1 protein is involved in the metastasis of colon cancer LOVO cells via regulating the ROS/ERK pathway in the H-R process. | yes |
24,593,165 | Is tNFα but not IL-17 critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcγRIIB-deficient mouse model? | {
"contexts": [
"TNFα and IL-17 have been shown to be the major inflammatory cytokines involved in the pathogenesis of rheumatoid arthritis (RA). Here, we examined the effect of these cytokines on spontaneously occurring RA in our newly established arthritis-prone FcγRIIB- deficient C57BL/6 (B6) mice, designated ... | TNFα is indispensable while IL-17 is dispensable in the pathogenesis of RA in KO1 mice. In this model, TNFα may contribute to the development of arthritis, through mediating the increase in frequencies of osteoclast precursors in circulation and their migration into the joints, and the decrease in OPG expression, leadi... | yes |
24,589,182 | Is a gene-specific non-enhancer sequence critical for expression from the promoter of the small heat shock protein gene αB-crystallin? | {
"contexts": [
"Deciphering of the information content of eukaryotic promoters has remained confined to universal landmarks and conserved sequence elements such as enhancers and transcription factor binding motifs, which are considered sufficient for gene activation and regulation. Gene-specific sequences, inter... | These data suggest that gene-specific sequences such as the GPS, identified here, may have critical roles in regulating gene-specific activity from eukaryotic promoters. | yes |
24,589,181 | Does calreticulin protect rat microvascular endothelial cells against microwave radiation-induced injury by attenuating endoplasmic reticulum stress? | {
"contexts": [
"This study was designed to evaluate whether exogenous CRT was beneficial for alleviating MR-induced injury by suppressing ER stress in rat MMECs.",
"MMECs were pretreated with CRT (25 pg/mL) for 12 hours, followed by the exposure to 2.856 GHz radiation at a mean power density of 30 mW/cm(2) f... | Exogenous CRT attenuates MR-induced ER stress-related apoptosis by suppressing CHOP-mediated apoptotic signaling pathways in MMECs. | yes |
24,615,873 | Does modification of the Lund-Kennedy endoscopic scoring system improve its reliability and correlation with patient-reported outcome measures? | {
"contexts": [
"To compare three existing endoscopic scoring systems and a newly proposed modified scoring system for the assessment of patients with chronic rhinosinusitis (CRS).",
"Blinded, prospective cohort study.",
"CRS patients completed two patient-reported outcome measures (PROMs)-the visual anal... | Modification of the LK system by excluding the subscores of scarring and crusting improves its reliability and its correlation with PROMs. In addition, the MLK system retains the familiarity of the widely used LK system and is applicable to any patient irrespective of surgical status. The MLK system may be a more suita... | yes |
24,606,398 | Does radiation-inducible HtrA2 gene enhance radiosensitivity of uveal melanoma OCM-1 cells in vitro and in vivo? | {
"contexts": [
"To explore an effective approach for the treatment of patients with uveal melanomas, we designed a strategy that combines HtrA2 gene therapy and radiation therapy.",
"pIRES-Egr1-Omi/HtrA2 (pEgr1-HtrA2) recombinant plasmids were constructed and transfected into human uveal melanoma cells (OCM-... | Our findings indicate that radiation-inducible gene therapy may have potential to be a more effective and specific therapy for uveal melanoma because the therapeutic gene can be spatially or temporally controlled by exogenous radiation. | yes |
24,606,050 | Is the frequency of alcohol consumption associated with the stroke mortality? | {
"contexts": [
"The purpose of this study was to examine the association between the frequency of alcohol consumption and stroke mortality among eastern Finnish men.",
"This study is a population-based sample of men with an average follow-up of 20.2 years. A total of 2609 men with no history of stroke at bas... | This study shows a strong association between the frequency of alcohol consumption and stroke mortality, independent of total amount of alcohol consumption. The risk of stroke death was the highest among men who consumed alcohol >2.5 times per week. | yes |
24,612,773 | Does high-intensity interval training alter ATP pathway flux during maximal muscle contractions in humans? | {
"contexts": [
"High-intensity interval training (HIT) results in potent metabolic adaptations in skeletal muscle; however, little is known about the influence of these adaptations on energetics in vivo. We used magnetic resonance spectroscopy to examine the effects of HIT on ATP synthesis from net PCr breakdown... | These alterations to muscle ATP production in vivo indicate that brief, maximal contractions are performed with increased support of oxidative ATP synthesis and relatively less contribution from anaerobic ATP production following training. These results extend previous reports of molecular and cellular adaptations to H... | yes |
24,615,276 | Is lower air temperature associated with ambulance transports and death in Takamatsu area , Japan? | {
"contexts": [
"The aim of this study was to investigate the linkage among ambulance transports, the number of death and air temperature in Takamatsu area, Japan.",
"Monthly data of ambulance transports (total and acute disease) and the number of death from 2004 to 2012 were obtained from Fire Department Ser... | Although higher air temperature was only associated with higher ambulance transports, lower air temperature was associated with both higher ambulance transports and the number death in Takamatsu area, Japan. | yes |
24,594,405 | Do an intricate network of conserved DNA upstream motifs and associated transcription factors regulate the expression of uromodulin gene? | {
"contexts": [
"Uromodulin is a kidney specific glycoprotein whose expression can modulate kidney homeostasis. However, the set of sequence specific transcription factors that regulate the uromodulin gene UMOD and their upstream binding locations are not well characterized. We built a high resolution map of its ... | Our findings will form a map for understanding the regulation of uromodulin expression in health and disease. | yes |
24,599,803 | Does nitrite therapy improve left ventricular function during heart failure via restoration of nitric oxide-mediated cytoprotective signaling? | {
"contexts": [
"Nitric oxide (NO) bioavailability is reduced in the setting of heart failure. Nitrite (NO2) is a critically important NO intermediate that is metabolized to NO during pathological states. We have previously demonstrated that sodium nitrite ameliorates acute myocardial ischemia/reperfusion injury.... | These results support the emerging concept that nitrite therapy may be a viable clinical option for increasing NO levels and may have a practical clinical use in the treatment of heart failure. | yes |
24,594,856 | Is pathological impact of hepatitis B virus surface proteins on the liver associated with the host genetic background? | {
"contexts": [
"While the immune pathogenesis caused by hepatitis B virus (HBV) infection has been studied extensively, little is known about direct pathogenic effects of HBV surface proteins. Here, we have investigated pathological cellular effects of HBV surface protein expression in the liver of transgenic mi... | Extent of liver injury, fibrosis, and tumour development induced by hepatic HBV surface protein expression considerably depends on host genetic background. | yes |
24,587,374 | Does transcriptomic profile reveal gender-specific molecular mechanisms driving multiple sclerosis progression? | {
"contexts": [
"Although the most common clinical presentation of multiple sclerosis (MS) is the so called Relapsing-Remitting MS (RRMS), the molecular mechanisms responsible for its progression are currently unknown. To tackle this problem, a whole-genome gene expression analysis has been performed on RRMS pati... | The interpretation of the modules of the coexpression network suggests that Epstein-Barr virus (EBV) reactivation of B cells happens in MS relapses; however, qPCR expression data of the viral genes supports that hypothesis only in female patients, reinforcing the notion that different molecular processes drive disease ... | yes |
24,587,379 | Does negative pressure wound therapy decrease mortality in a murine model of burn-wound sepsis involving Pseudomonas aeruginosa infection? | {
"contexts": [
"The colonization of burn wounds by Pseudomonas aeruginosa can lead to septic shock, organ injuries, and high mortality rates. We hypothesized that negative pressure wound therapy (NPWT) would decrease invasion and proliferation of P. aeruginosa within the burn wound and reduce mortality.",
"T... | Our data indicate that NPWT inhibits the invasion and proliferation of P. aeruginosa in burn-wounded tissue and decreases early mortality in a murine model of burn-wound sepsis. These therapeutic benefits likely result from the ability of NPWT to decrease bacterial proliferation on the wound surface, reduce cytokine se... | yes |
24,602,238 | Are thyroid antibodies associated with stenotic lesions in the terminal portion of the internal carotid artery? | {
"contexts": [
"Several studies have reported moyamoya syndrome associated with thyroid disease, and the mechanism involved in this relationship is unknown. This study aimed to clarify the involvement of thyroid antibodies and thyroid function in intracranial arterial stenosis.",
"The study included 30 patie... | In young and middle-aged patients, a lesion in the terminal portion of the internal carotid artery was associated with elevated thyroid antibody levels and increased thyroid function. Stenoses found in the terminal portion of the internal carotid artery and immune-mediated thyroid diseases may share a common background... | yes |
24,615,808 | Do i Collect Therefore I am -- Autonoetic Consciousness and Hoarding in Asperger Syndrome? | {
"contexts": [
"A growing number of studies have highlighted impairments in the ability of individuals with autism spectrum disorders to recall specific, personally experienced material. These difficulties have been related to underlying problems with autonoetic consciousness, namely the subjective awareness of ... | People with Asperger syndrome can have problems in developing a functional sense of self. Collecting and hoarding behaviour by people with Asperger syndrome may reflect such underlying difficulties in their sense of self rather than being symptoms of comorbid mental illness. Interventions need to take account of the fu... | yes |
24,612,434 | Is the protein expression profile of meningioma cells associated with distinct cytogenetic tumour subgroups? | {
"contexts": [
"Limited information exists about the impact of cytogenetic alterations on the protein expression profiles of individual meningioma cells and their association with the clinicohistopathological characteristics of the disease. The aim of this study is to investigate the potential association betwee... | Here we show that the protein expression profile of individual meningioma cells is closely associated with tumour cytogenetics, which may reflect the involvement of different signalling pathways in the distinct cytogenetic subgroups of meningiomas, with specific immunophenotypic profiles also translating into a differe... | yes |
24,608,150 | Are serum levels of omentin altered in drug-naive patients with major depression : a pilot study? | {
"contexts": [
"Decreased plasma levels of omentin, a relatively novel adipokine, are shown to be associated with metabolic abnormalities and proinflammatory states. Although other adipokines such as leptin and adiponectin have been extensively investigated in patients with major depressive disorder (MDD), no st... | This is the first investigation of omentin levels in patients with MDD. The hypothesis that circulating omentin levels would be different in depressed patients than in healthy controls is not supported by our data. | no |
24,602,372 | Does next generation sequencing with copy number variant detection expand the phenotypic spectrum of HSD17B4-deficiency? | {
"contexts": [
"D-bifunctional protein deficiency, caused by recessive mutations in HSD17B4, is a severe, infantile-onset disorder of peroxisomal fatty acid oxidation. Few affected patients survive past two years of age. Compound heterozygous mutations in HSD17B4 have also been reported in two sisters diagnosed ... | Our case expands the phenotypic spectrum of HSD17B4-deficiency, representing the first male case reported with infertility. Furthermore, it points to crosstalk between mitochondria and peroxisomes in HSD17B4-deficiency and Perrault syndrome. | yes |
24,594,348 | Does excision of Mullerian duct remnant for persistent Mullerian duct syndrome provide favorable short- and mid-term outcomes? | {
"contexts": [
"In dealing with persistent Mullerian duct syndrome (PMDS), excision of Mullerian duct remnant (MDR) has been rarely mentioned in the past, but recent discussions have taken place. This study aimed to evaluate the operative feasibility and outcomes.",
"Three patients with PMDS operated on with... | Excision of MDR is technically feasible, and provides favorable outcomes in cases of a single operation. For experienced surgeons, immediate reconstruction should be the priority when this abnormality is incidentally encountered at an age suitable for orchiopexy. | yes |
24,593,693 | Does noninvasive fractional flow on MRA predict stroke risk of intracranial stenosis? | {
"contexts": [
"Fractional flow may identify hemodynamic effects and ischemic risk beyond percent stenosis of an artery. We hypothesized that diminished TOF-MRA signal intensity distal to an intracranial stenosis predicts stroke risk.",
"TOF-MRA was acquired prospectively in the SONIA-WASID trials. The dista... | Fractional flow assessed by TOF-MRA SIR may be a useful noninvasive tool to identify high-risk intracranial lesions. | yes |
24,602,921 | Does rituximab modulate IL-17 expression in the salivary glands of patients with primary Sjögren 's syndrome? | {
"contexts": [
"The aim of this study was to evaluate the role of rituximab (RTX) in modulating the expression of the IL-17/IL-23 pathway in the salivary glands (SGs) of patients with primary SS (pSS).",
"Consecutive SG biopsies were obtained from 15 patients with pSS before and after 1 year of RTX therapy. ... | RTX acts on pSS patients by globally reducing the expression of IL-17 and specifically inducing a pronounced apoptotic depletion of mast cells. | yes |
24,604,452 | Do three-dimensional pulmonary perfusion MRI with radial ultrashort echo time and spatial-temporal constrained reconstruction? | {
"contexts": [
"To assess the feasibility of spatial-temporal constrained reconstruction for accelerated regional lung perfusion using highly undersampled dynamic contrast-enhanced (DCE) three-dimensional (3D) radial MRI with ultrashort echo time (UTE).",
"A combined strategy was used to accelerate DCE MRI f... | The proposed method is promising for fast and flexible 3D pulmonary perfusion imaging. Magn Reson | yes |
24,603,102 | Does prophylactic sildenafil citrate improve select aspects of sexual function in men treated with radiotherapy for prostate cancer? | {
"contexts": [
"We studied adjuvant daily sildenafil citrate during and after radiotherapy for prostate cancer for erectile function preservation.",
"We performed a randomized, prospective trial of 279 patients with localized prostate cancer treated with radiotherapy who received sildenafil citrate (50 mg da... | Daily sildenafil citrate during and after radiotherapy for prostate cancer was associated with improved overall sexual function compared with placebo for various sexual function domains. To our knowledge this is the largest randomized, prospective, controlled trial to show the usefulness of a phosphodiesterase-5 inhibi... | yes |
24,586,945 | Is area level deprivation an independent determinant of prevalent type 2 diabetes and obesity at the national level in Germany . Results from the National Telephone Health Interview Surveys 'German Health Update ' GEDA 2009 and 2010? | {
"contexts": [
"There is increasing evidence that prevention programmes for type 2 diabetes mellitus (T2DM) and obesity need to consider individual and regional risk factors. Our objective is to assess the independent association of area level deprivation with T2DM and obesity controlling for individual risk fac... | Area level deprivation is an independent, important determinant of T2DM and obesity prevalence in Germany. Identifying and targeting specific area-based risk factors should be considered an essential public health issue relevant to increasing the effectiveness of diabetes and obesity prevention. | yes |
24,602,286 | Does silencing of ETS1 reverse adriamycin resistance in MCF-7/ADR cells via downregulation of MDR1? | {
"contexts": [
"Clinical resistance to chemotherapeutic agents is one of the major hindrances in the treatment of human cancers. Erythroblastosis virus E26 oncogene homolog 1 (ETS1) is involved in the drug resistance of various cancer cells, and is overexpressed in drug-resistant human breast cancer cell lines. ... | This study demonstrates that drug resistance can be effectively reversed in adriamycin-resistant breast carcinoma cells through delivery of siRNAs targeting ETS1. | yes |
24,613,166 | Do previous coronary stents increase early and long-term adverse outcomes in patients undergoing off-pump coronary artery bypass grafting : a propensity-matched comparison? | {
"contexts": [
"The aim of our study was to compare the early and long-term outcomes of patients undergoing off-pump coronary artery bypass grafting (CABG) with and without previous coronary stents.",
"Between September 2004 and September 2011, 269 patients with previous stents underwent first-time isolated ... | Previous coronary stents do not increase early and long-term morbidity or mortality in patients undergoing off-pump CABG. | no |
24,613,160 | Is graft patency after off-pump coronary artery bypass surgery inferior even with identical heparinization protocols : results from the Danish On-pump Versus Off-pump Randomization Study ( DOORS )? | {
"contexts": [
"To determine whether graft patency after on-pump and off-pump coronary artery bypass surgery is similar when performed using the same heparinization protocol.",
"In a randomized, controlled, multicenter trial, 900 patients more than 70 years of age received either on-pump or off-pump coronary... | Despite comparable heparinization, graft patency after off-pump surgery was inferior to that after on-pump surgery. | yes |
24,613,168 | Does chronic competitive flow from a patent arterial or venous graft to the circumflex system impair the long-term patency of internal thoracic artery to left anterior descending grafts in patients with isolated predivisional left main disease : long-term angiographic results of 2 different revascularization strategies... | {
"contexts": [
"To compare 2 different surgical approaches to treatment of patients with isolated predivisional stenosis of the left main coronary artery (IOSLM) and to evaluate the effect of chronic competitive flow from a patent arterial or venous graft to the circumflex system on the long-term patency of inte... | In patients with IOSLM, long-term ITA to left anterior descending artery patency is not jeopardized by chronic flow competition from a concomitant arterial or venous graft to the circumflex system. Notably, the addition of a second ITA graft or of a SV to the first ITA does not lead to differences in long-term angiogra... | no |
24,584,175 | Does probucol suppress macrophage infiltration and MMP expression in atherosclerotic plaques of WHHL rabbits? | {
"contexts": [
"Probucol is a lipid-lowering drug that is often prescribed for the treatment of familial hypercholesterolemia. However, it is not known whether probucol can change the lesion quality of atherosclerosis.",
"We examined this possibility using WHHL rabbits, a model of human familial hypercholest... | These results suggest that probucol treatment may have beneficial effects on the plaque stability of hypercholesterolemic patients. | yes |
24,607,509 | Do β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo? | {
"contexts": [
"The fruit hull of Garcinia mangostana Linn. has been used in traditional medicine for treatment of various inflammatory diseases. Hence, this study aims to investigate the in vitro and in vivo anti-inflammatory effect of β mangostin (βM), a major compound present in Garcinia mangostana.",
"Th... | The current study supports the traditional use of Garcinia mangostana fruit hull for treatment of inflammatory conditions. In addition, it is clear that the anti-inflammatory efficacy of this plant is not limited to the presence of α and γ, but β also with significant activity. | yes |
24,595,101 | Is genetic variant in MTRR , but not MTR , associated with risk of congenital heart disease : an integrated meta-analysis? | {
"contexts": [
"Congenital heart disease (CHD) is one of the most common birth defects and the leading cause of deaths among individuals with congenital structural abnormalities worldwide. Both Methionine synthase reductase (MTRR) and Methionine synthase (MTR) are key enzymes involved in the metabolic pathway of... | This meta-analysis demonstrated a suggestive result that the A66G variant in MTRR, but not the A2756G in MTR, may be associated with the increase of CHD risks. | yes |
24,596,158 | Is diaphragm dysfunction in heart failure accompanied by increases in neutral sphingomyelinase activity and ceramide content? | {
"contexts": [
"Chronic heart failure (CHF) causes inspiratory (diaphragm) muscle weakness and fatigue that contributes to dyspnoea and limited physical capacity in patients. However, the mechanisms that lead to diaphragm dysfunction in CHF remain poorly understood. Cytokines and angiotensin II are elevated in C... | Our major novel finding was that diaphragm dysfunction in CHF rats was accompanied by higher diaphragm neutral SMase activity, which is expected to cause the observed increase in diaphragm ceramide content. | yes |
24,593,809 | Does iCAM-2 regulate vascular permeability and N-cadherin localization through ezrin-radixin-moesin ( ERM ) proteins and Rac-1 signalling? | {
"contexts": [
"Endothelial junctions control functions such as permeability, angiogenesis and contact inhibition. VE-Cadherin (VECad) is essential for the maintenance of intercellular contacts. In confluent endothelial monolayers, N-Cadherin (NCad) is mostly expressed on the apical and basal membrane, but in th... | These results indicate that ICAM-2 regulates endothelial barrier function and permeability through a pathway involving N-Cadherin, ERMs and Rac-1. | yes |
24,603,645 | Does c-reactive protein concentration predict change in body mass index during childhood? | {
"contexts": [
"Inflammation may constitute an underlying mechanism for increased risk of developing chronic diseases in later years, but few prospective studies have assessed the influence of low-grade inflammation on body weight gain, particularly among children in low- to middle-income settings with lower pre... | We found evidence of a role for low-grade inflammation in predicting annual BAZ gain among children aged >5 years. | yes |
24,600,178 | Do the attitude of Iranian nurses about resuscitate orders? | {
"contexts": [
"Do not resuscitate (DNR) orders are one of many challenging issues in end of life care. Previous research has not investigated Muslim nurses' attitudes towards DNR orders.",
"This study aims to investigate the attitude of Iranian nurses towards DNR orders and determine the role of religious s... | Iranian nurses, regardless of their religious sects, reported negative attitude towards many aspects of DNR orders. It may be possible to change the attitude of Iranian nurses towards DNR through education. | no |
24,608,342 | Does overexpression of OLC1 promote tumorigenesis of human esophageal squamous cell carcinoma? | {
"contexts": [
"OLC1 was recently identified to be a potential oncogene. However, the role of OLC1 in human esophageal cell carcinoma (ESCC) is unknown. The aim of this study was therefore to evaluate the expression of OLC1 in human ESCC from normal, premalignant, and malignant lesions, and to clarify the mechan... | Our study provides strong evidence suggesting OLC1 abnormalities may contribute to the development of human ESCC and have some important clinical significance. | yes |
24,592,372 | Does extremely low-frequency electromagnetic field influence the survival and proliferation effect of human adipose derived stem cells? | {
"contexts": [
"Extremely low-frequency electromagnetic fields (ELF-EMF) can effect on biological systems and alters some cell functions like proliferation rate. Therefore, we aimed to attempt the evaluation effect of ELF-EMF on the growth of human adipose derived stem cells (hADSCs).",
"ELF-EMF was generate... | Our results show that between 0.5 m and 1 mT ELF-EMF could be enhances survival and PE of hADSCs conserving the duration of exposure. | yes |
24,606,711 | Is polyphenol intake in elderly people associated with lipid oxidative damage? | {
"contexts": [
"We hypothesized an association between physiological amounts of different classes and subclasses of polyphenol from a subject's regular diet and lipid peroxidation.",
"Diet was assessed through direct observation and a semiquantitative food frequency questionnaire. Daily polyphenol intake, to... | This study represents one of the few attempts to date to evaluate the impact of phenol intake on oxidative damage. Flavonoids intake must be promoted to reduce the negative health effects of oxidative stress in elderly people. | yes |
24,606,714 | Is nutritional status in sick children and adolescents accurately reflected by BMI-SDS? | {
"contexts": [
"Nutritional status provides helpful information of disease severity and treatment effectiveness. Body mass index standard deviation scores (BMI-SDS) provide an approximation of body composition and thus are frequently used to classify nutritional status of sick children and adolescents. However, ... | Using BMI-SDS to determine nutritional status in a sick population is not considered an appropriate clinical tool for identifying individual underweight or overweight children or adolescents. However, BMI-SDS may be appropriate for longitudinal measurements or for screening purposes in large field studies. When accurat... | no |
24,616,042 | Is duration of the pre-diagnostic interval in medulloblastoma subgroup dependent? | {
"contexts": [
"Children presenting with medulloblastoma have a wide range of initial presenting symptoms. However, the influence of underlying tumor biology on the initial presentation of medulloblastoma is currently unknown. In light of the recent discovery of distinct medulloblastoma subgroups, we sought to d... | The duration of the pre-diagnostic interval in childhood medulloblastoma is highly subgroup dependent, further highlighting the clinical heterogeneity and biological relevance of the four principle subgroups of medulloblastoma. | yes |
24,595,210 | Is genetic variation in genes encoding airway epithelial potassium channels associated with chronic rhinosinusitis in a pediatric population? | {
"contexts": [
"Apical potassium channels regulate ion transport in airway epithelial cells and influence air surface liquid (ASL) hydration and mucociliary clearance (MCC). We sought to identify whether genetic variation within genes encoding airway potassium channels is associated with chronic rhinosinusitis (... | We have implicated two airway epithelial potassium channels as novel susceptibility loci in contributing to the pathogenesis of CRS. | yes |
24,605,984 | Is magnitude of efficacy measurements in grass allergy immunotherapy trials highly dependent on pollen exposure? | {
"contexts": [
"The objective was to evaluate the association between grass pollen exposure, allergy symptoms and impact on measured treatment effect after grass sublingual immunotherapy (SLIT)-tablet treatment.",
"The association between grass pollen counts and total combined rhinoconjunctivitis symptom and... | In seasonal allergy trials with grass SLIT-tablet, the observed treatment effect is highly dependent on pollen exposure with the magnitude being greater with higher pollen exposure. This is an important relationship to consider when interpreting individual clinical trial results. | yes |
24,593,914 | Does hypoxia-conditioned media allow species-specific attraction of bone marrow stromal cells without need for recombinant proteins? | {
"contexts": [
"In vivo tissue regeneration depends on migration of stem cells into injured areas, their differentiation into specific cell types, and their interaction with other cells that are necessary to generate new tissue. Human mesenchymal stem cells, a subset of bone marrow stromal cells (BMSCs), can mig... | Generation of HCM is easy and cheap compared to preparation and purification of protein fractions and/or recombinant proteins. Hence, HCM could be applied in large animals (e.g. sheep, horse, dogs) for attraction of BMSCs into tissue defects caused by tumor resection or trauma. | yes |
24,610,450 | Does the chicken egg and skull model of endoscopic endonasal transsphenoidal surgery improve trainee drilling skills? | {
"contexts": [
"We verified the effectiveness of training in endoscopic endonasal transsphenoidal surgery (eETSS) techniques using chicken eggs and a skull model.",
"We verified the area of eggshell removed by drilling when five residents and four experts used the chicken eggs and a skull model.",
"When ... | Our findings suggest that this training method could be adequate for acquiring eETSS techniques. Although experts showed superior endoscopic manipulation, residents may also be able to acquire adequate endoscopic skills through further training, and our training method appears to offer an effective means of improving e... | yes |
24,588,367 | Does air-oxidized linalool elicit eczema in allergic patients - a repeated open application test study? | {
"contexts": [
"Linalool is a commonly used fragrance terpene that forms potent sensitizers upon oxidation. In a recent multicentre study, we found that 7% of 2900 patients showed positive patch test reactions to oxidized linalool at 6.0%. No elicitation studies have been performed.",
"To identify threshold ... | Repeated exposure to low concentrations of oxidized linalool can elicit allergic contact dermatitis in previously sensitized individuals. | yes |
24,604,111 | Does botulinum toxin a decrease calf pain or improve ROM during limb lengthening : a randomized trial? | {
"contexts": [
"During lower limb lengthening, distraction-induced muscle pain and surrounding joint contractures are frustrating complications for which few effective treatments are available.",
"We evaluated Botulinum Toxin Type A (BtX-A) injection in the calf muscles during human tibial distraction osteog... | Local injection of 200 IU BtX-A at the human calf muscle does not appear to reduce calf pain or help enhance ROM of the knee and ankle during tibial lengthening. However, the small sample size provided sufficient power to detect only relatively large clinical effects; future, larger trials will be needed to determine w... | no |
24,613,307 | Do neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis? | {
"contexts": [
"Autophagy is a fundamental cell biological process whereby eukaryotic cells form membranes in the cytoplasm to sequester diverse intracellular targets. Although significant progress has been made in understanding the origins of autophagosomal organelles, the source of lipids that support autophag... | Lipid droplets contribute to autophagic capacity by enhancing it in a process dependent on PNPLA5. Thus, neutral lipid stores are mobilized during autophagy to support autophagic membrane formation. | yes |
24,597,615 | Do three clinically distinct chronic pediatric airway infections share a common core microbiota? | {
"contexts": [
"DNA-based microbiological studies are moving beyond studying healthy human microbiota to investigate diverse infectious diseases, including chronic respiratory infections, such as those in the airways of people with cystic fibrosis (CF) and non-CF bronchiectasis. The species identified in the res... | Our results indicate that these clinically distinct chronic airway infections share common early core microbiota, which are likely shaped by natural aspiration and impaired clearance of the same airway microbes, but that disease-specific characteristics select for divergent microbiota by adulthood. Longitudinal and int... | yes |
24,607,627 | Does monoamine oxidase A suppress hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling? | {
"contexts": [
"Monoamine oxidase A (MAOA), a catecholamine neurotransmitter degrading enzyme, is closely associated with neurological and psychiatric disorders. However, its role in cancer progression remains unknown.",
"Hepatocellular carcinoma (HCC) tissue arrays (n=254) were used to investigate the corre... | Taken together, the results of our study may provide insights into the application of MAOA as a novel predictor of clinical outcomes and indicate that increasing MAOA expression or enzyme activity may be a new approach that can be used for HCC treatment. | yes |
24,593,159 | Does exometabolome analysis reveal hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process? | {
"contexts": [
"Scale-up to industrial production level of a fermentation process occurs after optimization at small scale, a critical transition for successful technology transfer and commercialization of a product of interest. At the large scale a number of important bioprocess engineering problems arise that ... | An optimized S. cerevisiae fermentation process was successfully scaled-up to an industrial scale bioreactor. The oxygen uptake rate (OUR) and overall growth profiles were matched between scales. The major remaining differences between scales were wet cell weight and culture apparent viscosity. The metabolic and physio... | yes |
24,589,197 | Does the impact of CHIP premium increase on insurance outcomes among CHIP eligible children? | {
"contexts": [
"Within the United States, public insurance premiums are used both to discourage private health policy holders from dropping coverage and to reduce state budget costs. Prior research suggests that the odds of having private coverage and being uninsured increase with increases in public insurance p... | When faced with higher CHIP premiums, private health insurance may be a preferable alternative for CHIP eligible families with higher incomes. Therefore, competition in the insurance exchanges being formed under the Affordable Care Act could enhance choice. | yes |
24,589,192 | Does in vivo imaging of mice infected with bioluminescent Trypanosoma cruzi unveil novel sites of infection? | {
"contexts": [
"The development of techniques that allow the imaging of animals infected with parasites expressing luciferase opens up new possibilities for following the fate of parasites in infected mammals.",
"D-luciferin potassium salt stock solution was prepared in phosphate-buffered saline (PBS) at 15 ... | Bioluminescence imaging is accurate for tracking parasites in vivo, and this methodology is important to gain a better understanding of the infection, tissue inflammation, and parasite biology regarding host cell interaction, proliferation, and parasite clearance to subpatent levels. | yes |
24,591,029 | Does dietary protein content affect isotopic carbon and nitrogen turnover? | {
"contexts": [
"Isotopic turnover quantifies the metabolic renewal process of elements in organs and excreta. Knowledge of the isotopic turnover of animal organs and excreta is necessary for diet reconstruction via stable isotope analysis, as used in animal ecology, palaeontology and food authentication. Effects... | The renewal times of organs and excreta depend on the dietary protein content. Hence, isotopic diet reconstruction is confronted with variation in half-lives within the same organ or excrement, altering the time window through which information can be perceived. | yes |
24,591,023 | Does deglycosylation induce extensive dynamics changes in α-amylase revealed by hydrogen/deuterium exchange mass spectrometry? | {
"contexts": [
"N-Linked glycosylation plays important roles in modulating protein structure and function. The direct impact of the modification on protein conformation is not yet well understood.",
"Here we probed the dynamic changes following Endo H trimming of high mannose glycans in α-amylase by means of... | The overall exchange rate is reduced in the glycosylated state, which indicates rigidity enhancement due to the attached carbohydrates. | yes |
24,589,426 | Does movement demands of elite rugby league players during Australian National Rugby League and European Super League match? | {
"contexts": [
"This study compared the movement demands of players competing in matches from the elite Australian and European rugby league competitions.",
"Global positioning system devices were used to measure 192 performances of forwards, adjustables, and outside backs during National Rugby League (NRL; ... | NRL players have better maintenance of high-speed running between the first and second halves of matches and perform less low- and moderate-speed activity, indicating that the NRL provides a higher standard of rugby league competition than the SL. | yes |
24,603,314 | Do retinoid X receptor agonists inhibit hypertension-induced myocardial hypertrophy by modulating LKB1/AMPK/p70S6K signaling pathway? | {
"contexts": [
"Retinoid X receptor (RXR) has been demonstrated to play an important role in cardiac development and has been implicated in cardiovascular diseases. This study aimed to examine the effects of RXRα agonist bexarotene on pathological left ventricular hypertrophy (LVH) in a spontaneously hypertensiv... | RXR agonists prevent the inhibition of the LKB1/AMPK/p70S6K pathway and regulate protein synthesis to reduce LVH. This antihypertrophic effect of bexarotene is independent of blood pressure. | yes |
24,608,747 | Is trait impulsivity associated with the risk of falls in Parkinson 's disease? | {
"contexts": [
"Impulsivity is a \"tendency to act prematurely without foresight.\" Clinical experience suggests that such impulsive behavior can impact on the fall risk in Parkinson's disease (PD), but this has never been tested. We investigated whether trait impulsivity is related to fall risk in a large cohor... | This is the first evidence that impulsivity, in particular in the attentional domain, is related to fall risk in PD. | yes |
24,591,540 | Is brugada syndrome ECG highly prevalent in schizophrenia? | {
"contexts": [
"The causes of increased risk of sudden cardiac death in schizophrenia are not resolved. We aimed to establish (1) whether ECG markers of sudden cardiac death risk, in particular Brugada-ECG pattern, are more prevalent among patients with schizophrenia, and (2) whether increased prevalence of thes... | Brugada-ECG has increased prevalence among patients with schizophrenia. This association is not explained by the use of sodium channel-blocking medication. | yes |
24,607,718 | Is a novel trafficking-defective HCN4 mutation associated with early-onset atrial fibrillation? | {
"contexts": [
"Atrial fibrillation (AF) is the most common arrhythmia, and a recent genome-wide association study identified the hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) as a novel AF susceptibility locus. HCN4 encodes for the cardiac pacemaker channel, and HCN4 mutations are associa... | Our findings are consistent with HCN4 haploinsufficiency as the likely mechanism for early-onset AF in the p.Pro257Ser carrier. | yes |
24,587,299 | Does high expression of protein tyrosine kinase 7 significantly associate with invasiveness and poor prognosis in intrahepatic cholangiocarcinoma? | {
"contexts": [
"The incidence, prevalence, and mortality of intrahepatic cholangiocarcinoma (ICC) are increasing worldwide. Protein tyrosine kinase-7 (PTK7) is upregulated in many common human cancers. However, its expression in ICC has not been studied. The present study aimed to explore the underlying mechanis... | PTK7 expression plays an important role in the invasiveness of ICC cells and leads to a poor prognosis in ICC patients. Thus, PTK7 can be used as a prognostic indicator, and the inhibition of PTK7 expression could be a new therapeutic target for ICC. | yes |
24,612,760 | Does totally thoracoscopic repair of atrial septal defect reduce systemic inflammatory reaction and myocardial damage in initial patients? | {
"contexts": [
"To compare the effect of totally thoracoscopic with conventional, open repair of atrial septal defect.",
"Forty atrial septal defect cases were divided into two groups by surgical approach: totally thoracoscopic approach (group A, n = 20) and conventional open approach (group B, n = 20). In g... | Thoracoscopic cardiac surgery is technically feasible and safe, with less trauma and quicker recovery even when done by a surgeon newly introduced to the technique. | yes |
24,595,716 | Is restless legs syndrome related to obstructive sleep apnea symptoms during pregnancy? | {
"contexts": [
"To investigate the relation between restless legs syndrome (RLS) and obstructive sleep apnea symptoms during pregnancy.",
"A questionnaire consisting of diagnostic criteria of restless legs syndrome, demographic characteristics, personal behavior, muscle cramps during pregnancy, past medical ... | Increasing awareness of restless legs syndrome among obstetricians is essential as it might be related to obstructive sleep apnea syndrome, which is associated with adverse pregnancy outcomes. | yes |
24,599,663 | Do [ Retropupillary iris claw intraocular lens implantation technique for aphakia ]? | {
"contexts": [
"Overview of the retropupillary implantation of iris claw intraocular lenses (Artisan®,Ophtec, Groningen, Niederlande and Verisyse(TM),AMO, Santa Ana CA).",
"A literature search and review of implantation techniques, patient selection, potential complications and management strategies.",
"... | The retropupillary implantation of iris claw intraocular lenses is an interesting and especially time-effective rehabilitation technique for aphakia. | yes |
24,589,155 | Is microvascular glycocalyx dimension estimated by automated SDF imaging related to cardiovascular disease? | {
"contexts": [
"The EG regulates vascular homeostasis and has anti-atherogenic properties. SDF imaging allows for noninvasive visualization of microvessels and automated estimation of EG dimensions. We aimed to assess whether microcirculatory EG dimension is related to cardiovascular disease.",
"Sublingual E... | Microcirculatory EG dimension, as estimated by automated SDF imaging, is not associated with CVD, suggesting that this technique may not contribute to cardiovascular risk stratification. | no |
24,603,000 | Is normal saline to dilute parenteral drugs and to keep catheters open a major and preventable source of hypernatremia acquired in the intensive care unit? | {
"contexts": [
"We wanted to identify modifiable risk factors for intensive care unit (ICU)-acquired hypernatremia.",
"We retrospectively studied sodium and fluid loads and balances up to 7 days prior to the development of hypernatremia (first serum sodium concentration, [Na+], >150 mmol/L; H) vs control (ma... | High sodium input by 0.9% saline used to dilute drugs and keep catheters open is a modifiable risk factor for ICU-acquired H. Dissolving drugs in dextrose 5% may partially prevent potentially harmful sodium overloading and H. | yes |
24,601,752 | Does mR imaging of the substantia nigra at 7 T enable diagnosis of Parkinson disease? | {
"contexts": [
"To evaluate the anatomy of the substantia nigra (SN) in healthy subjects by performing 7-T magnetic resonance (MR) imaging of the SN, and to prospectively define the accuracy of 7-T MR imaging in distinguishing Parkinson disease (PD) patients from healthy subjects on an individual basis.",
"T... | MR imaging at 7-T allows a precise characterization of the SN and visualization of its inner organization. Three-dimensional multiecho susceptibility-weighted images can be used to accurately differentiate healthy subjects from PD patients, which provides a novel diagnostic opportunity. | yes |
24,600,488 | Does serine threonine kinase Pim-3 regulate STAT3 pathway to inhibit proliferation of human liver cancers? | {
"contexts": [
"This study aimed to investigate the effects of serine threonine kinase Pim-3 on the growth of HepG2 cells and to explore the role of STAT3 signaling pathway.",
"Synthetic Pim-3shRNA and negative control shRNA were independently transfected into HepG2 cells in the presence of Lipofectamine(TM)... | Pim-3 shRNA may down-regulate pSTAT3(Tyr705) and pBad(Ser112) protein expression to inhibit the proliferation of liver cancer cells and Pim-3 may serve as a target for the treatment of liver cancer. | yes |
24,611,923 | Does counselor-assisted problem solving improve caregiver efficacy following adolescent brain injury? | {
"contexts": [
"The purpose of the current study is to examine the efficacy of Counselor-Assisted Problem Solving (CAPS) in improving caregiver adaptation following traumatic brain injury (TBI).",
"In a randomized clinical trial comparing CAPS (n = 65), an online problem-solving intervention with accompanyin... | Findings support the potential utility of counselor-supported Web-based interventions particularly for individuals with limited computer expertise following adolescent TBI. | yes |
24,602,382 | Does zinc transporter-1 concentrate at the postsynaptic density of hippocampal synapses? | {
"contexts": [
"Zinc concentrates at excitatory synapses, both at the postsynaptic density and in a subset of glutamatergic boutons. Zinc can modulate synaptic plasticity, memory formation and nociception by regulating transmitter receptors and signal transduction pathways. Also, intracellular zinc accumulation ... | Our study has identified ZnT1 as a novel postsynaptic density protein, and it may help elucidate the role of zinc homeostasis in synaptic function and disease. | yes |
24,588,811 | Are circulating human microRNAs linked to JC polyomavirus serology or urinary viral load in healthy subjects? | {
"contexts": [
"JC polyomavirus (JCPyV) is a widespread human polyomavirus that usually resides latently in its host. It can be reactivated under immunomodulating conditions and cause Progressive Multifocal Leukoencephalopathy (PML). Circulating microRNAs (miRNAs) are emerging as promising biomarkers for several... | This study could not identify circulating human miRNAs that were differentially expressed between plasma from JCPyV seropositive and JCPyV seronegative subjects or between JCPyV shedders and JCPyV non-shedders. | no |
24,596,636 | Do dental pulp polyps contain stem cells comparable to the normal dental pulps? | {
"contexts": [
"Few studies investigated the isolation of stem cells from pathologically injured dental tissues. The aim of this study was to assess the possibility of isolation of stem cells from pulp polyps (chronic hyperplastic pulpitis), a pathological tissue produced in an inflammatory proliferative respons... | The cells isolated from pulp polyps fulfill minimal criteria needed for MSC definition; hence, it can be concluded that pulp polyps contain stem cells. Although pulp polyps are rare tissues in daily practice but when they are present, may serve as a possible new non-invasively acquired tissue resource of stem cells for... | yes |
24,609,795 | Does zwolle risk score predict contrast-induced acute kidney injury in STEMI patients undergoing PCI? | {
"contexts": [
"Contrast-induced acute kidney injury (CI-AKI) is a common complication in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). The Mehran risk score was defined originally in elective PCI and may be predictive of CI-AKI. The a... | Zwolle score predicts CI-AKI slightly better than the Mehran score in patients with STEMI undergoing primary PCI. This simple score can be used at the catheterization laboratory for risk stratification for the development of CI-AKI. | yes |
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