pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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|---|---|---|---|---|
26,854,046 | Does comminution play no role in worsening fracture healing of conservatively treated middle third clavicular fractures? | {
"contexts": [
"Middle third clavicular fracture is effectively treated by conservative means. Previous studies showed that comminution and displacement of clavicular fractures might affect fracture healing. However, the clavicle horizontally aligns in the shoulder girdle and has different biomechanics from vert... | Comminution plays no role in worsening fracture healing of conservatively treated middle third clavicular fractures in terms of healing rate, union complications, and union configurations. | yes |
26,857,091 | Does obesity decrease B cell responses in young and elderly individuals? | {
"contexts": [
"To evaluate the effects of obesity-associated inflammation on influenza vaccine responses.",
"In young and elderly individuals, both lean and with obesity, antibody responses to influenza vaccination were measured.",
"A decrease in in vivo vaccine responses, circulating switched memory, a... | These results demonstrate that leptin can be responsible for decreased B cell function in obesity. | yes |
26,867,158 | Is arpin downregulation in breast cancer associated with poor prognosis? | {
"contexts": [
"The Arp2/3 complex is required for cell migration and invasion. The Arp2/3 complex and its activators, such as the WAVE complex, are deregulated in diverse cancers. Here we investigate the expression of Arpin, the Arp2/3 inhibitory protein that antagonises the WAVE complex.",
"We used qRT-PCR... | Loss of the Arp2/3 inhibitory protein Arpin produces a similar poor outcome in breast cancer as high expression of the NCKAP1 subunit of the Arp2/3 activatory WAVE complex. | yes |
26,867,055 | Are circulating resistin concentrations independently associated with aortic pulse wave velocity in a community sample? | {
"contexts": [
"The role of the adipokine, resistin in mediating increases in aortic stiffness is uncertain. We aimed to determine independent relations between circulating resistin concentrations and aortic pulse wave velocity (PWV) and wave reflection in a community-based sample with a high prevalence of untre... | Resistin is independently and directly associated with aortic stiffness and these effects occur beyond BP, insulin resistance, and general inflammation. | yes |
26,856,696 | Does sodium thiosulfate attenuate glial-mediated neuroinflammation in degenerative neurological diseases? | {
"contexts": [
"Sodium thiosulfate (STS) is an industrial chemical which has also been approved for the treatment of certain rare medical conditions. These include cyanide poisoning and calciphylaxis in hemodialysis patients with end-stage kidney disease. Here, we investigated the anti-inflammatory activity of S... | Although NaSH was somewhat more powerful than STS in these in vitro assays, STS has already been approved as an orally available treatment. STS may therefore be a candidate for treating neurodegenerative disorders that have a prominent neuroinflammatory component. | yes |
26,850,448 | Does fusion cytokine IL-2-GMCSF enhance anticancer immune responses through promoting cell-cell interactions? | {
"contexts": [
"Potent antitumor responses can be induced through cytokine immunotherapy. Interleukin (IL)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF) are among the most effective cytokines to induce tumor-specific systemic immune responses and can act synergistically. To overcome the limitat... | These results suggested that IL2-GMCSF can efficiently regulate immune responses against tumors. Furthermore, as the bridging effect relies on both IL-2R and GM-CSFR and promotes interactions between immune and tumor cells, IL2-GMCSF may be utilized as a useful tool for dissecting specific immune responses for future c... | yes |
26,851,312 | Does health Insurance affect Head and Neck Cancer Treatment Patterns and Outcomes? | {
"contexts": [
"The purpose of this study is to examine the effect of insurance coverage on stage of presentation, treatment, and survival of head and neck cancer (HNC).",
"A retrospective study was conducted using the Surveillance, Epidemiology, and End Results (SEER) program to identify patients diagnosed ... | Uninsured patients and patients with Medicaid are more likely to present with metastatic disease, are more likely to not be treated definitively, and are at a higher risk of HNCSM. The treatment gap between Medicaid and private insurance observed in this study should serve as an immediate policy target for health care ... | yes |
26,859,129 | Is spontaneous endogenous pulsatile release of kisspeptin temporally coupled with luteinizing hormone in healthy women? | {
"contexts": [
"To evaluate the presence of a spontaneous pulsatile release of kisspeptin and whether it is temporally coupled to LH pulses.",
"Experimental study.",
"Academic medical center.",
"Thirty young healthy eumenorrheic women aged 20-37 years were included in the study group. All subjects we... | The present study provides evidence supporting the hypothesis that kisspeptin is highly relevant in the regulation and modulation of reproductive functions in humans. | yes |
26,849,905 | Does globular adiponectin attenuate LPS-induced reactive oxygen species production in HepG2 cells via FoxO3A and HO-1 signaling? | {
"contexts": [
"Adiponectin has been shown to possess potent anti-oxidative properties in various experimental conditions. However, its anti-oxidative effects and underlying mechanisms have not been reported in liver cells. Herein, we investigated the effects of globular adiponectin (gAcrp) on LPS-stimulated rea... | These results suggest that gAcrp prevents LPS-induced ROS production and NADPH oxidase activity in HepG2 cells via FoxO3A and HO-1 signaling-dependent mechanisms. The present study demonstrated a suppressive effect of adiponectin on ROS production in liver cells and presented a novel mechanism underlying suppression of... | yes |
26,875,905 | Does cardiac shock wave therapy show better outcomes in the coronary artery disease patients in a long term? | {
"contexts": [
"Almost all the past CSWT studies show the beneficial effects on CAD patients in a maximum duration of 1-year follow-up. The aim of this study was to evaluate the actual CSWT effects in 6 years follow-up period.",
"The subjects were selected exclusively on the basis of inclusion criteria. The ... | Following 6 years of follow-up, the CSWT provided agreeable results that improved myocardial function and quality of life in comparing to the month 0 and the control group. These outcomes advise that on a long-term (72 months) CSWT shows better parameters than the control group. These findings highlight that CSWT can i... | yes |
26,875,904 | Is plasma microRNA-21 a potential diagnostic biomarker of acute myocardial infarction? | {
"contexts": [
"Previous studies have demonstrated that microRNA-21 (miR-21) is involved in the pathogenesis of myocardium infarction and cardiac fibrosis; the present study aimed to investigate its potential role in the diagnosis of acute myocardium infarction (AMI).",
"A cohort of patients with AMI and ang... | Plasma miR-21 may be a novel biomarker for the diagnosis of AMI. Our study may also provide implications for the development of new biomarkers. | yes |
26,848,471 | Does rib Fracture Fixation restore Inspiratory Volume and Peak Flow in a Full Thorax Human Cadaveric Breathing Model? | {
"contexts": [
"Multiple rib fractures cause significant pain and potential for chest wall instability. Despite an emerging trend of surgical management of flail chest injuries, there are no studies examining the effect of rib fracture fixation on respiratory function.",
"Using a novel full thorax human cada... | Negative pressure inspiration is significantly impaired by an unstable chest wall. Restoring mechanical stability of the fractured ribs improves respiratory outcomes similar to baseline values. | yes |
26,854,442 | Is heat shock protein 70 a useful marker for predicting colorectal cancer? | {
"contexts": [
"In colorectal cancer (CRC), as in most of other malignancies, heat shock proteins (HSPs) are overexpressed and are associated with apoptosis, cancer cell proliferation, differentiation, invasion, and metastasis. HSP70 is one of the HSPs and has a promising future in cancer studies for both diagno... | This study shows that the serum level of HSP70 is elevated in patients with CRC. HSP70 may be utilized as an adjunct to other diagnostic or screening tests. | yes |
26,854,445 | Are antiproliferative and apoptotic effects of the ethanolic herbal extract of Achillea falcata in human cervical cancer cells mediated via cell cycle arrest and mitochondrial membrane potential loss? | {
"contexts": [
"Cervical carcinoma is the second most common malignancy in females and most of the cases are found in developing countries. The objectives of the present study were (a): to demonstrate the antiproliferative and apoptotic effects of Achillea falcata (A.falcata) extract in human cervical cancer cel... | Achillea falcata extract induced potent antiproliferative and apoptotic effects in HeLa cells. This was accompanied by cellular shrinkage, chromatin condensation, G2/M phase cell cycle arrest and a loss of mitochondrial membrane potential in these cancer cells. | yes |
26,862,912 | Do hospitalizations of more than 5 days predict for worse outcomes after radiotherapy for head and neck cancer? | {
"contexts": [
"Patients undergoing chemoradiation for head and neck squamous cell carcinoma (HNSCC) are predisposed to unplanned hospitalizations.",
"To assess the factors associated with prolonged hospitalization and its impact on patient outcomes.",
"We assessed the outcomes of patients hospitalized f... | As a retrospective review, we report only hypothesis-generating observations, which may have been affected by having incomplete patient information. | yes |
26,850,872 | Does modified Mandibular Inferior Border Sagittal Split Osteotomy reduce Postoperative Risk for Developing Inferior Border Defects? | {
"contexts": [
"The purpose of this study was to evaluate the impact of a modified sagittal split osteotomy (SSO) surgical technique on the incidence of persisting inferior border defects. The secondary aim was to identify risk factors associated with the development of these complications.",
"The patient ch... | This study confirms the findings previously reported by our research group that the modified inferior border osteotomy technique in SSO results in a substantial lower frequency of persisting inferior border defects. Surgeons are advised to ensure that the lingual cortex of the inferior border is not included in the spl... | yes |
26,861,585 | Is l1CAM an independent predictor of poor survival in endometrial cancer - An analysis of The Cancer Genome Atlas ( TCGA )? | {
"contexts": [
"L1-cell adhesion molecule (L1CAM) was previously reported to carry a poor prognosis in Stage I, low-risk endometrial cancer (EC). We evaluated the role of L1CAM among all stages and histologies in ECs in The Cancer Genome Atlas (TCGA).",
"Clinical information and RNA-Seq expression data were ... | L1CAM expression is an independent predictor of poor survival in endometrial cancer, and is associated with advanced stage, high-risk endometrial cancer. | yes |
26,861,581 | Does intensive Simulation Training in Lower Limb Arterial Duplex Scanning lead to Skills Transfer in Real-World Scenario? | {
"contexts": [
"To train novices to perform an abbreviated duplex lower limb ultrasound scan using simulation training and assess real-world skills transference.",
"Novices undertook 3 days of simulation training. Their progress was assessed using the Duplex Ultrasound Objective Structured Assessment of Tech... | Intensive simulation of 3-day training achieved real patient-based assessments that were comparable to MSc students who were 3 months into their traditional training program. | yes |
26,861,583 | Do dental Student Hand Hygiene Decreased With Increased Clinical Experience? | {
"contexts": [
"To investigate the effectiveness, related knowledge, attitudes, and practices of hand hygiene (HH) among dental students with different levels of clinical experience.",
"This was a cross-sectional analytical study. Bacterial samples on the participants' hands were obtained using a swab techni... | HH effectiveness, attitudes, and practices of dental students decreased as students gained more clinical experience, whereas knowledge did not. Our results suggest that HH instruction should be given throughout the duration of dental students' education. | yes |
26,870,824 | Is plasma Concentration of the Neurofilament Light Protein ( NFL ) a Biomarker of CNS Injury in HIV Infection : A Cross-Sectional Study? | {
"contexts": [
"Cerebrospinal fluid (CSF) neurofilament light chain protein (NFL) is a sensitive marker of neuronal injury in a variety of neurodegenerative conditions, including the CNS dysfunction injury that is common in untreated HIV infection. However, an important limitation is the requirement for lumbar p... | These results show that plasma NFL may prove a valuable tool to evaluate ongoing CNS injury in HIV infection that may be applied in the clinic and in research settings to assess the presence if active CNS injury. Because CSF NFL is also elevated in a variety of other CNS disorders, sensitive measures of plasma NFL may ... | yes |
26,878,340 | Does inhibition of protease-activated receptor 4 impair platelet procoagulant activity during thrombus formation in human blood? | {
"contexts": [
"Essentials The platelet thrombin receptor, PAR4, is an emerging anti-thrombotic drug target. We examined the anti-platelet & anti-thrombotic effects of PAR4 inhibition in human blood. PAR4 inhibition impaired platelet procoagulant activity in isolated cells and during thrombosis. Our study shows ... | Background Thrombin-induced platelet activation is important for arterial thrombosis. Thrombin activates human platelets predominantly via protease-activated receptor (PAR)1 and PAR4. PAR1 has higher affinity for thrombin, and the first PAR1 antagonist, vorapaxar, was recently approved for use as an antiplatelet agent.... | yes |
26,852,254 | Do postpartum Hemorrhage Preparedness Elements Vary Among Hospitals in New Jersey and Georgia? | {
"contexts": [
"To identify the presence or absence of 38 postpartum hemorrhage preparedness elements in hospitals in New Jersey and Georgia as a component of the Postpartum Hemorrhage Project of the Association of Women's Health, Obstetric and Neonatal Nurses.",
"Quality improvement baseline assessment surv... | Objective measures of preparedness are needed, because perceptions of preparedness were inconsistent with the number of preparedness elements reported. | yes |
26,851,839 | Does subclinical neurological involvement develop if Wilson 's disease is treated early? | {
"contexts": [
"Wilson's disease (WD) is a genetic disorder of copper metabolism causing dysfunctions of various organs, mostly the liver and brain. If untreated, WD is fatal, but early treatment results in a good prognosis, although the long-term neurological outcome has not yet been clarified. To address this ... | This study suggests that early diagnosis and treatment of WD may prevent the onset of neurologic damage, even at subclinical level. | no |
26,878,793 | Is resveratrol equipotent to perindopril in attenuating post-infarct cardiac remodeling and contractile dysfunction in rats? | {
"contexts": [
"Angiotensin-converting enzyme (ACE) inhibitors improve prognosis in patients with post-myocardial infarction (MI) related cardiac dysfunction. Resveratrol is a polyphenol that has been reported to be beneficial in hypertension, ischemic heart disease, and cardiotoxicity in preclinical studies. Ac... | Treatment with resveratrol or perindopril was equivalent in significantly improving remodeling and attenuation of contractile dysfunction in MI rats. Combination treatment also attenuated the cardiac abnormalities. The improvement in cardiac abnormalities may partly be through reducing oxidative stress by preventing th... | yes |
26,865,913 | Does vitamin A supplementation modify the antioxidant system in rats? | {
"contexts": [
"It has been shown that vitamin A supplementation has different effects on skeletal health and the antioxidant system. Deficiency or excess of this vitamin can lead to health problems. Vitamin A can work as either an antioxidant or prooxidant depending on its concentration. The present study was c... | These results indicate that appropriate supplementation of vitamin A might have a beneficial effect on the antioxidant system in rats. | yes |
26,865,910 | Does oligonol promote anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway? | {
"contexts": [
"Oligonol, mainly found in lychee fruit, is an antioxidant polyphenolic compound which has been shown to have anti-inflammatory and anti-cancer properties. The detailed mechanisms by which oligonol may act as an anti-aging molecule have not been determined.",
"In this study, we evaluated the a... | These data demonstrated that oligonol may act as an anti-aging molecule by modulating SIRT1/autophagy/AMPK pathways. | yes |
26,865,894 | Do c-reactive protein and procalcitonin predict anastomotic leaks following colorectal cancer resections - a prospective study? | {
"contexts": [
"Early safe discharge is paramount for the success of ERAS following colorectal cancer resections. Anastomotic leakage (AL) has high morbidity, particularly if the patient has been discharged to the community.",
"To evaluate whether C-reactive protein (CRP) and procalcitonin (PCT) can predict ... | C-reactive protein and PCT measurement on POD 3 following colorectal cancer resection can positively identify patients at low risk of anastomotic leakage. | yes |
26,871,645 | Is overcrowding in Psychiatric Wards Associated With Increased Risk of Adverse Incidents? | {
"contexts": [
"To study the association between bed occupancy in psychiatric wards and rate of adverse incidents (AIs) including aggressive behavior and falls.",
"This is a retrospective study analyzing bed occupancy and AIs' data in 4 closed wards in a state psychiatric hospital in Israel over a 20-month p... | Overoccupancy is prevalent in psychiatric wards and is associated with an increased rate of aggressive AIs and falls. Policy makers should be convinced about the necessity to reduce overcrowding in psychiatric wards and to improve safety of inpatient facilities. | yes |
26,860,254 | Does selective Intra-procedural AAA sac Embolization During EVAR reduce the Rate of Type II Endoleak? | {
"contexts": [
"The pre-treatment presence of at least six efferent patent vessels (EPV) from the AAA sac and/or AAA thrombus volume ratio (VR%) <40% are considered to be positive predictive factors for persistent type II endoleak (ELIIp). The aim of the present study was to evaluate the effectiveness of sac emb... | Selective intra-procedural AAA sac embolization in patients with p-MRF is safe and could be an effective method to reduce ELIIp. Further studies are mandatory to support these results at long-term follow up. | yes |
26,859,315 | Are serum heart type fatty acid binding protein levels changed in hyperthyroidism? | {
"contexts": [
"Heart type fatty acid binding protein (H-FABP) is a small protein and released into the circulation when myocardial damage has occurred. Previous studies have demonstrated that H-FABP is closely associated with cardiac and some endocrinologic disorders including prediabetes, metabolic syndrome, a... | Serum H-FABP levels are not altered in patients with hyperthyroidism. | no |
26,867,504 | Does beta-arrestin 2 rather than G protein efficacy determine the anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor ligands? | {
"contexts": [
"Nociceptin/orphanin FQ (N/OFQ) receptor (NOP) agonists produce anxiolytic-like effects in rodents while antagonists promote antidepressant-like effects. The aim of this study was to investigate the effect on anxiety and depression of NOP receptor partial agonists such as the peptides [F/G]N/OFQ(1... | NOP ligands producing similar effects on NOP/G protein interaction (partial agonism) but showing different effects on β-arrestin 2 recruitment (partial agonism vs antagonism) elicited different actions on anxiety and mood. These results suggest that the action of a NOP ligand on emotional states is better predicted bas... | yes |
26,849,418 | Does anticlostridial agent 8-hydroxyquinoline improve the isolation of faecal bifidobacteria on modified Wilkins-Chalgren agar with mupirocin? | {
"contexts": [
"The need for suitable selective cultivation media for the isolation of Bifidobacterium spp. continues to be a real concern in the field of intestinal microbiology. Isolation of bifidobacteria from human and animal faecal samples using selective agar plating may be problematic especially in sample... | Routine isolation of bifidobacteria from mammalian faeces does not use a reliable selective agar with an anticlostridial agent. Overgrowth of clostridia may result in incorrect estimation of bifidobacterial counts. Thus, in order to improve the selectivity of existing media for bifidobacterial isolation, we chose the m... | yes |
26,850,041 | Does subchronic exposure to static magnetic field differently affect zinc and copper content in murine organs? | {
"contexts": [
"Static magnetic fields (SMF) have been widely used in research, medicine and industry. Since zinc and copper play an important role in biological systems, we studied the effects of the subchronic continuous SMF exposure on their distribution in murine tissues.",
"For 30 days, mice were expose... | Subchronic exposure to SMF differently affected copper and zinc content in examined organs, and the changes were more pronounced for the downward oriented field. The outcome could be attributed to the protective, rather than the harmful effect of SMF. | yes |
26,871,640 | Is caregivers ' Self-Reported Absence of Social Support Networks Related to Treatment Abandonment in Children With Cancer? | {
"contexts": [
"Treatment abandonment (TxA) is a primary cause of therapy failure in children with cancer in low-/middle-income countries. We explored the absence of social support network (SSN), among other predictive factors, and TxA in children with cancer in Cali, Colombia.",
"In this prospective cohort ... | We found a strong association between the absence of SSN and TxA that was independent of other covariates, including surrogate measures of wealth. Our findings highlight the imperative understanding of social ties and support surrounding children's families for planning strategies to prevent TxA. | yes |
26,860,745 | Do intrinsic differences between males and females determine sex-specific consequences of inbreeding? | {
"contexts": [
"Inbreeding increases homozygosity and exposes deleterious recessive alleles, generally decreasing the fitness of inbred individuals. Interestingly, males and females are usually affected differently by inbreeding, though the more vulnerable sex depends on the species and trait measured.",
"We... | These results suggest that females experience stronger selection on genes contributing to reproductive traits. Inbreeding depression in males may be further reduced by sex chromosome hemizygosity, which affects the dominance of some mutations, as well as by the absence of sexual selection. Determining the relative cont... | yes |
26,873,084 | Is incidental findings of uncertain significance : To know or not to know -- that the question? | {
"contexts": [
"Although the \"right not to know\" is well established in international regulations, it has been heavily debated. Ubiquitous results from extended exome and genome analysis have challenged the right not to know. American College of Medical Genetics and Genomics (ACMG) Recommendations urge to info... | This article investigates how the various arguments for and against a right not to know hold for IFUS. The main investigated arguments are: hypothetical utilitarianism, the right-based argument, the feasibility argument, the value of knowledge argument, the argument from lost significance, the empirical argument, the d... | no |
26,854,970 | Is hbA1c significantly associated with arterial stiffness but not with carotid atherosclerosis in a community-based population without type 2 diabetes : The Dong-gu study? | {
"contexts": [
"We examined the associations between HbA1c levels and various atherosclerotic vascular parameters among adults without diabetes from the general population.",
"A total of 6500 community-dwelling adults, who were free of type 2 diabetes and ≥50 years of age, were included. High-resolution B-mo... | High-normal HbA1c level was independently associated with arterial stiffness, but not with carotid atherosclerotic parameters, in the general population without diabetes. Our results suggest that the functional atherosclerotic process may already be accelerated according to HbA1c level, even at a level below the diagno... | yes |
26,855,629 | Is the Need for a Step-up in Postoperative Medical Care Predictable in Orthopedic Patients Undergoing Elective Surgery? | {
"contexts": [
"The goal of elective orthopedic surgery is to return patients to their expected level of activity without an increased incidence of postoperative complications. The first step is identifying patient and/or surgical characteristics responsible for these complications.",
"This study sought to i... | In an elderly population with multiple comorbidities undergoing elective common major orthopedic procedures, approximately 2% of patients required readmission to the PACU. The most common problems requiring this step-up in care were cardiac and pulmonary, which resulted in an increased length of hospital stay. Patients... | yes |
26,855,622 | Does initial Surgical Treatment of Humeral Shaft Fracture predict Difficulty Healing when Humeral Shaft Nonunion Occurs? | {
"contexts": [
"Although most humeral nonunions are successfully treated with a single procedure, some humeral nonunions are more difficult to heal and require multiple procedures. Current literature does not provide evidence describing how the prognosis for surgical repair in patients who develop humeral diaphy... | Humeral shaft nonunions following initial operative fixation of the index fracture is more resistant to achieving union when compared to nonunions forming after initial nonoperative treatment. When final healing is achieved, there is no difference in function or pain. | yes |
26,850,675 | Do early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve? | {
"contexts": [
"Acute ischemia is a major cause of sudden arrhythmic death, further promoted by potassium current blockers. Macro-reentry around the ischemic region and early afterdepolarizations (EADs) caused by electrotonic current have been suggested as potential mechanisms in animal and isolated cell studies... | Electrotonically-triggered EADs are identified as a potential mechanism facilitating intramural reentry in a regionally-ischemic human ventricles model with reduced repolarization reserve. | yes |
26,872,014 | Does microRNA-361-5p inhibit Cancer Cell Growth by Targeting CXCR6 in Hepatocellular Carcinoma? | {
"contexts": [
"A growing body of evidence supports the notion that MicroRNAs (miRNAs) function as key regulators of tumorigenesis. In the present study, the expression and roles of miRNA-361-5p were explored in hepatocellular carcinoma (HCC).",
"Quantitative real-time PCR was used to detect the expression m... | Our results indicate that miR-361-5p acts as a tumor suppressor and might serve as a novel therapeutic target for the treatment of HCC patients. | yes |
26,848,822 | Does transfusion of recently donated ( fresh ) red blood cells ( RBCs ) improve survival in comparison with current practice , while safety of the oldest stored units is yet to be established : a meta-analysis? | {
"contexts": [
"Preclinical studies generated the hypothesis that older stored red blood cells (RBCs) can increase transfusion risks. To examine the most updated and complete clinical evidence and compare results between two trial designs, we assessed both observational studies and randomized controlled trials (... | RCTs established that transfusion of 1- to 10-day-old stored RBCs is not superior to current practice. The apparent discrepancy in mortality between analyses of RCTs and observational studies may in part relate to differences in hypotheses tested and ages of stored RBCs studied. Further trials investigating 1- to 10-da... | no |
26,855,987 | Do clinical characteristics and medication use patterns among hospitalized patients admitted with psychotic vs nonpsychotic major depressive disorder? | {
"contexts": [
"In routine practice, major depressive disorder (MDD) with psychotic features often goes under-recognized and undertreated. Previous research has specified several demographic and clinical differences in MDD patients with psychotic features compared with those without psychosis in routine outpatie... | Several demographic and clinical characteristics differentiate MDD patients with psychosis from those without psychosis in hospital settings that may be helpful in identifying these patients. Comparisons with outpatient samples and treatments implications are discussed. | yes |
26,858,771 | Does the antiviral compound BIT225 inhibit HIV-1 replication in myeloid dendritic cells? | {
"contexts": [
"Previous studies with BIT225 (N-carbamimidoyl-5-(1-methyl-1H-pyrazol-4-yl)-2-naphthamide) have demonstrated a unique antiviral activity that blocks the release of HIV-1 from monocyte-derived macrophages (MDM). Antagonising the ion channel formed by HIV-1 Vpu, BIT225 preferentially targets de novo... | HIV-1 release from MDDC was inhibited by BIT225. This data broadens the drug's antiviral activity profile within cells of the myeloid lineage. These findings suggest a potential role for BIT225 in reducing HIV-1 production and preventing viral dissemination in early and chronic infection and may assist in limiting viru... | yes |
26,866,907 | Is iron prioritized to red blood cells over the brain in phlebotomized anemic newborn lambs? | {
"contexts": [
"Critically ill preterm and term neonates are at high risk for negative iron balance due to phlebotomy that occurs with frequent laboratory monitoring, and the high iron demand of rapid growth. Understanding the prioritization of iron between red blood cells (RBCs) and brain is important given iro... | Phlebotomy-induced negative iron balance limits iron availability to the developing brain. | yes |
26,856,963 | Do the relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use? | {
"contexts": [
"The previous use of antibiotics is known to correlate positively with antibiotic resistance; whether this is also the case in the eradication of Helicobacter pylori infection is unclear.",
"To investigate the relationship between the previous use of antibiotics and the failure of eradication ... | A patient's history of macrolides is a useful predictor of the likelihood of standard triple therapy failure in H. pylori eradication. The alternatives such as a bismuth-based quadruple or a levofloxacin-containing therapy should be considered in patients treated with macrolides for >2 weeks. | yes |
26,863,878 | Is cerebrospinal fluid lactate associated with multiple sclerosis disease progression? | {
"contexts": [
"Altered cerebrospinal fluid (CSF) levels of lactate have been described in neurodegenerative diseases and related to mitochondrial dysfunction and neuronal degeneration. We investigated the relationship between CSF lactate levels, disease severity, and biomarkers associated with neuroaxonal damag... | Measurement of CSF lactate may be helpful, in conjunction with other biomarkers of tissue damage, as an early predictor of disease severity in RRMS patients. A better understanding of the alterations of mitochondrial metabolic pathways associated to RRMS severity may pave the way to new therapeutic targets to contrast ... | yes |
26,851,467 | Does active workstation allow office workers to work efficiently while sitting and exercising moderately? | {
"contexts": [
"To determine the effects of a moderate-intensity active workstation on time and error during simulated office work.",
"The aim of the study was to analyse simultaneous work and exercise for non-sedentary office workers. We monitored oxygen uptake, heart rate, sweating stains area, self-percei... | Although moderate intensity exercise performed on cycling workstation during simulated office tasks increases working task execution time with, it has moderate effect size; however, it does not increase the error rate. Participants confirmed that such a working design is suitable for achieving the minimum standards for... | yes |
26,860,771 | Does deletion of Men1 and somatostatin induce hypergastrinemia and gastric carcinoids? | {
"contexts": [
"Gastric carcinoids are slow growing neuroendocrine tumours arising from enterochromaffin-like (ECL) cells in the corpus of stomach. Although most of these tumours arise in the setting of gastric atrophy and hypergastrinemia, it is not understood what genetic background predisposes development of ... | Gastric carcinoids require threshold levels of hypergastrinemia, which modulates p27 | yes |
26,850,270 | Does divergent adherence estimate with pharmacokinetic and behavioural measures in the MTN-003 ( VOICE ) study? | {
"contexts": [
"In the Microbicide Trial Network MTN-003 (VOICE) study, a Phase IIB pre-exposure prophylaxis trial of daily oral or vaginal tenofovir (TFV), product adherence was poor based on pharmacokinetic (PK) drug detection in a random subsample. Here, we sought to compare behavioural and PK measures of adh... | PK measures indicated similarly low adherence for the oral and vaginal groups. No behavioural measure accurately predicted PK non-adherence. Accurate real-time measures to monitor product adherence are urgently needed. | yes |
26,872,557 | Is season of diagnosis associated with overall survival in patients with diffuse large B-cell lymphoma but not with Hodgkin 's lymphoma - A population-based Swedish Lymphoma Register study? | {
"contexts": [
"The aim of this study was to investigate the effect of season of diagnosis on the outcome of patients with diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL). In this study, we included curatively treated DLBCL (n = 5875) and HL (n = 1693) patients, diagnosed between 2000 and 2011, b... | In summary, season of diagnosis was shown to have impact on overall survival in male patients with DLBCL. Possible explanations of our results are the higher vitamin D level during the summer months, the effects of sunlight on the circadian rhythm and the immune system, or the lower risk of infectious disease during th... | yes |
26,851,035 | Does high NEK2 Expression be a Predictor of Tumor Recurrence in Hepatocellular Carcinoma Patients After Hepatectomy? | {
"contexts": [
"Better prognosis of cancer including hepatocellular carcinoma (HCC) remains unsatisfactory due to recurrence and chemoresistance. In this respect it is important to identify molecular targets specific to the disease in order to design effective therapeutic strategies. In the present study, we inv... | Overall, these results suggest that NEK2 could be a promising biomarker for HCC recurrence. | yes |
26,869,361 | Does low-dose paclitaxel ameliorate renal fibrosis by suppressing transforming growth factor-β1-induced plasminogen activator inhibitor-1 signaling? | {
"contexts": [
"To investigate the effect of microtubule stabilization with low-dose paclitaxel on renal fibrosis, focusing on the transforming growth factor-β1 (TGF-β1)-induced plasminogen activator inhibitor-1 (PAI-1) signaling cascade.",
"Forty-eight rats were randomly assigned to four groups: sham/vehicl... | Paclitaxel at low non-cytotoxic doses ameliorates renal fibrosis by inhibiting multiple steps in the TGF-β1-induced PAI-1 signaling including Smads and mitogen-activated protein kinases. | yes |
26,877,874 | Are rECQ helicases deregulated in hematological malignancies in association with a prognostic value? | {
"contexts": [
"RECQ helicase family members act as guardians of the genome to assure proper DNA metabolism in response to genotoxic stress. Hematological malignancies are characterized by genomic instability that is possibly related to underlying defects in DNA repair of genomic stability maintenance.",
"We... | RECQ helicase expression is deregulated in hematological malignancies compared to their normal counterparts in association with a prognostic value. Deregulation of RECQ helicases appears to play a role in tumorigenesis and represent potent therapeutic targets for synthetic lethal approaches in hematological malignancie... | yes |
26,860,119 | Is older patient hospital admissions following primary care referral : the truth in the referring? | {
"contexts": [
"Health information has a major role in the planning of future healthcare provision. With current reconfiguration and cost saving measures, further demands are being placed on acute hospitals.",
"To examine the elderly admissions and the referral documentation of older patients admitted to a t... | Almost all primary care referrals included the required details as per recent HIQA guidelines. The further inclusion of optional information relating to patient social or functional status, which are of particular relevance to the older population may help patient management. | yes |
26,857,535 | Does branched-chain amino acid-enriched nutrient increase blood platelet count in patients after endoscopic injection sclerotherapy? | {
"contexts": [
"Protein and energy malnutrition is a severe problem for patients with liver cirrhosis (LC) and fasting often induces starvation which is a vitally important outcome. Dietary restriction is essential for endoscopic injection sclerotherapy (EIS) in patients with risky esophageal varices, thereby cr... | EIS induced protein-energy malnutrition, however, skeletal muscle volume was maintained by taking BCAA. Administration of BCAA had some effect in maintaining the nutritional state, and may improve the platelet count. Taking a greater amount of nutrients and shorter dietary restriction period or hospitalization was desi... | yes |
26,857,375 | Does exosomal transfer of miR-30a between cardiomyocytes regulate autophagy after hypoxia? | {
"contexts": [
"Recent studies have indicated a protective role of physiological autophagy in ischemic heart disease. However, the underlying mechanisms of autophagy regulation after ischemia are poorly understood. Exosomes are nano-sized vesicles released from cells that play critical roles in mediating cell-to... | miR-30a is highly enriched in exosomes from the serum of AMI patients. Hypoxia induces miR-30a upregulation and enrichment into exosomes. MiR-30a is efficiently transferred via exosomes between hypoxic cardiomyocytes. Inhibition of exosome release contributes to maintaining of autophagy after hypoxia. Inhibition of miR... | yes |
26,867,141 | Does endurance Exercise improve Molecular Pathways of Aerobic Metabolism in Patients With Myositis? | {
"contexts": [
"Endurance exercise demonstrates beneficial effects in polymyositis/dermatomyositis (PM/DM); however, the molecular effects of exercise on skeletal muscle are incompletely understood. We undertook this controlled pilot study to investigate the effects of a 12-week endurance exercise training progr... | Our data indicate that endurance exercise in patients with established PM and DM may activate an aerobic phenotype and promote muscle growth and simultaneously suppress the inflammatory response in these patients' muscles, as supported by a combination of data on gene expression, proteomics, and capillary density in re... | yes |
26,851,287 | Does fracture clinic redesign reduce the cost of outpatient orthopaedic trauma care? | {
"contexts": [
"\"Virtual fracture clinics\" have been reported as a safe and effective alternative to the traditional fracture clinic. Robust protocols are used to identify cases that do not require further review, with the remainder triaged to the most appropriate subspecialist at the optimum time for review. ... | The virtual fracture clinic system was associated with less overall use of staff resources in comparison to national cost data. Adoption of this system nationally may have the potential to achieve significant cost savings.Cite this article: P. J. Jenkins. Fracture clinic redesign reduces the cost of outpatient orthopae... | yes |
26,875,899 | Is high dose amoxicillin-based first line regimen equivalent to sequential therapy in the eradication of H. pylori infection? | {
"contexts": [
"Helicobater (H.) pylori eradication rates with standard first-line triple therapy have declined to unacceptable levels. To date, amoxicillin-resistant H. pylori strains have rarely been detected. Whether increasing the dosage of amoxicillin in a standard 7 days eradicating regimen may enhance its... | High-dose amoxicillin based eradicating treatment is superior to standard triple therapy and equivalent to sequential therapy; compared to the latter, the shorter duration may represent an advantage. | yes |
26,849,632 | Is hydrogen Inhalation Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats? | {
"contexts": [
"Non-shockable rhythms represent an increasing proportion of reported cases of out-of-hospital cardiac arrest but with an associated poor prognosis. In the present study, we investigated the effects of hydrogen inhalation on cardiac and neurological function after cardiopulmonary resuscitation and... | Small amounts of inhaled hydrogen were superior to mild hypothermia in improving cardiac function and neurological outcome in this asphyxial rat model of cardiac arrest. | yes |
26,862,521 | Is sTAT3 Overactivated in Gastric Cancer Stem-Like Cells? | {
"contexts": [
"Gastric cancer (GC) is widely associated with chronic inflammation. The pro inflammatory microenvironment provides conditions that disrupt stem/progenitor cell proliferation and differentiation. The signal transducer and activator of transcrip- tion-3 (STAT3) signaling pathway is involved in infl... | The present findings point to STAT3 over activation in GCSLCs. Com- plementary experiments are required to extend the role of STAT3 in stemness fea- tures and invasion properties of GCSCs and to consider the STAT3 pathway for CSC targeted therapy. | yes |
26,875,907 | Does valsartan attenuate cardiac and renal hypertrophy in rats with experimental cardiorenal syndrome possibly through down-regulating galectin-3 signaling? | {
"contexts": [
"Aortocaval fistula (AV) induced chronic volume overload in rats with preexisting mild renal dysfunction (right kidney remove: UNX) could mimic the type 4 cardiorenal syndrome (CRS): chronic renocardiac syndrome. Galectin-3, a β-galactoside binding lectin, is an emerging biomarker in cardiovascula... | Up-regulated galectin-3 signaling might also be involved in the pathogenesis in this CRS model. The beneficial effects of valsartan in terms of attenuating cardiac and renal hypertrophy and reducing 24 hours albumin in this model might partly be mediated through down-regulating galectin-3 signal pathway. | yes |
26,875,908 | Does high-volume hemofiltration combined with early goal-directed therapy improve alveolar-arterial oxygen exchange in patients with refractory septic shock? | {
"contexts": [
"This study is to evaluate the effect of high-volume hemofiltration (HVHF) and early goal-directed therapy (EGDT) on alveolar-arterial oxygen exchange in patients with refractory septic shock.",
"Patients were classified into two groups by a prospective cohort study: 86 received both HVHF and ... | These findings demonstrated that HVHF, when used as an adjunctive therapy to the EGDP protocol, could improve alveolar-arterial oxygen exchange, clinical outcome and survival in patients with refractory septic shock. | yes |
26,876,434 | Are upregulation of inflammasome activity and increased gut permeability associated with obesity in children and adolescents? | {
"contexts": [
"Immune activation contributes to the persistent state of inflammation associated with metabolic dysfunction in obesity. The specific immune receptors that sense metabolic stress signals and trigger inflammation are nevertheless largely unknown, and little is known on inflammatory and immune gene ... | In children and adolescents, obesity is characterized by the activation of the inflammasome and by an alteration of gut permeability. Successful lifestyle modification is effective in reducing inflammation, suggesting that inhibition of the inflammasome may be a potential therapeutic strategy in obesity. | yes |
26,853,102 | Does percentage-Method improve Properties of Workers ' Sitting- and Walking-Time Questionnaire? | {
"contexts": [
"Does asking for the percentage of time spent sitting during work (P-method) instead of asking for the absolute length of time spent sitting (T-method) improve properties of the workers' sitting- and walking-time questionnaire (WSWQ)? The purpose of this study was to investigate whether questionin... | The study revealed that the P-method WSWQ had better reliability, validity, and ease of answering than the T-method, suggesting that the P-method can improve properties of the WSWQ and consequently advance the quality of epidemiological surveys in this field. | yes |
26,854,457 | Are anticancer effects of bishydroxycoumarin mediated through apoptosis induction , cell migration inhibition and cell cycle arrest in human glioma cells? | {
"contexts": [
"To evaluate the cytotoxic and apoptotic effects of bishydroxycoumarin (BHC) against human glioma cells and to study their mode of action.",
"Three cells were used in the experiments. MTT and LDH assays were used to assess the cytotoxic effects of BHC while an in vitro wound healing assay was ... | This study provides help to elucidate the translational potential of the in vitro results to be used for further in vivo studies on human glioma using animal or human subjects. The mechanistic pathway studied in this report could be helpful in explaining the mode of action of these classes of natural products. | yes |
26,854,455 | Is weight loss at the time of diagnosis associated with prognosis in patients with advanced-stage non-small cell lung cancer? | {
"contexts": [
"To investigate the prognostic value of weight loss before diagnosis in patients with advanced stage non-small cell lung cancer (NSCLC) treated with first-line chemotherapy.",
"A total of 81 NSCLC patients with stages IIIB/IV were included in this retrospective cross-sectional study. Study var... | Pre-diagnosis weight loss was found to have a negative impact on PFS in patients with NSCLC treated by first-line chemotherapy. Similar studies in larger patient series are warranted. | no |
26,854,125 | Does allosteric Modulation of Sigma-1 Receptors elicit Rapid Antidepressant Activity? | {
"contexts": [
"Sigma-1 receptors are involved in the pathophysiological process of several neuropsychiatric diseases such as epilepsy, depression. Allosteric modulation represents an important mechanism for receptor functional regulation. In this study, we examined antidepressant activity of the latest identifi... | SOMCL-668, a novel allosteric modulator of sigma-1 receptors, elicits a potent and rapid acting antidepressant effect. The present data provide the first evidence that allosteric modulation of sigma-1 receptors may represent a new approach for antidepressant drug discovery. | yes |
26,854,129 | Do common and rare CARD14 gene variants affect the antitumour necrosis factor response among patients with psoriasis? | {
"contexts": [
"The CARD14 gene encodes a protein that enhances nuclear factor (NF)-κB activation and the upregulation of proinflammatory pathway genes. CARD14 is upregulated in psoriatic vs. normal skin, and rare and common CARD14 variants have been associated with the risk of developing psoriasis. Our hypothes... | The common CARD14 p.Arg820Trp variant might have a significant effect on the response to anti-TNF therapies among patients with psoriasis. In addition, rare CARD14 missense variants could also predispose to a better response. | yes |
26,849,168 | Do a Multi-Stakeholder Process to Transform a Community-based Screening and Referral Program to Implement Evidence-Based Depression Care? | {
"contexts": [
"Screening and referral for geriatric depression by service agencies is associated with poor treatment engagement indicating the need to transform services to directly provide depression care.",
"To describe a multi-organization workgroup implementation planning process used to transform a com... | A multi-organization workgroup can benefit from a semi-structured implementation planning procedure because it provides all stakeholders with a shared roadmap for implementation planning. | yes |
26,851,022 | Does l-Carnosine prevent the Pro-cancerogenic Activity of Senescent Peritoneal Mesothelium Towards Ovarian Cancer Cells? | {
"contexts": [
"L-Carnosine inhibits senescence of somatic cells and displays anticancer activity. Here we analyzed if L-carnosine (20 mM) retards senescence of human peritoneal mesothelial cells (HPMCs) and inhibits progression of ovarian cancer cells.",
"Experiments were performed with primary HPMCs establ... | L-carnosine may be a valuable anticancer drug, especially in the context of prevention and therapy of intraperitoneal ovarian cancer metastasis. | yes |
26,869,278 | Does interleukin-6 trans-signaling induce VEGF synthesis partly via Janus kinases-STAT3 pathway in human mesothelial cells? | {
"contexts": [
"Interleukin-6 (IL-6) is a vital inflammatory factor in the peritoneal cavity of peritoneal dialysis (PD) patients. Because intraperitoneal inflammation is closely associated with angiogenesis, we sought to explore the effect of IL-6 on vascular endothelial growth factor (VEGF) synthesis and its t... | The present study might provide evidence that high glucose up-regulates IL-6 synthesis in Met-5A cells, to some extent, depending on its osmolality and that IL-6 trans-signaling could induce VEGF synthesis partly dependent on the JAK/STAT3 pathway. This article is protected by copyright. All rights reserved. | yes |
26,855,545 | Does staging laparoscopy improve treatment decision-making for advanced gastric cancer? | {
"contexts": [
"To evaluate the clinical value of staging laparoscopy in treatment decision-making for advanced gastric cancer (GC).",
"Clinical data of 582 patients with advanced GC were retrospectively analyzed. All patients underwent staging laparoscopy. The strength of agreement between computed tomograp... | Staging laparoscopy can improve treatment decision-making for advanced GC and decrease unnecessary exploratory laparotomy. | yes |
26,857,633 | Is simple radiographic assessment of bone quality associated with loss of surgical fixation in patients with proximal humeral fractures? | {
"contexts": [
"This study aimed to determine if the ratio of cortical thickness to shaft diameter of the humerus, as measured on a simple anterior-posterior shoulder radiograph, is associated with surgical fixation failure.",
"64 consecutive fractures in 63 patients (mean age 66.1 years, range 35-90) operat... | Medial cortex ratio is significantly associated with loss of surgical fixation and may prove to be a useful adjunct for clinical decision making in patients with proximal humeral fractures. | yes |
26,878,477 | Does the traditional Japanese medicine hangeshashinto alleviate oral ulcer-induced pain in a rat model? | {
"contexts": [
"Recent studies have demonstrated that mouthwash made with the traditional Japanese medicine hangeshashinto exhibits anti-inflammatory action and alleviates oral mucositis scores, including pain complaints, in patients undergoing chemoradiotherapy. However, no study has demonstrated the mechanism ... | Hangeshashinto leads to long-lasting analgesic effects, specifically in the ulcer region by destroying the epithelial barrier. Hangeshashinto alleviates oral ulcer-induced pain in inflammation-dependent and/or independent manner. | yes |
26,872,916 | Is the zebrafish fast myosin light chain mylpfa : H2B-GFP transgene a useful tool for in vivo imaging of myocyte fusion in the vertebrate embryo? | {
"contexts": [
"Skeletal muscle fibers are multinucleated syncytia that arise from the fusion of mononucleated precursors, the myocytes, during embryonic development, muscle hypertrophy in post-embryonic growth and muscle regeneration after injury. Even though myocyte fusion is central to skeletal muscle differe... | Since we know so little about the molecules regulating vertebrate myocyte fusion, we propose that the mylpfa:H2B-GFP transgene will be a very useful reporter for conducting forward and reverse genetic screens to identify new components regulating vertebrate myocyte fusion. | yes |
26,853,074 | Does rNA interference of cytochrome P450 CYP6F subfamily genes affect susceptibility to different insecticides in Locusta migratoria? | {
"contexts": [
"Many insect cytochrome P450s (CYPs) play critical roles in detoxification of insecticides. The CYP6 family is unique to the class Insecta, and its biochemical function has essentially been associated with the metabolism of xenobiotics. In this study, we sequenced and characterised the full-length... | Three of the four CYP6F subfamily genes in L. migratoria were associated with the detoxification of deltamethrin or carbaryl. The role of CYPs in insecticide detoxification appears to be both gene and insecticide specific. © 2016 Society of Chemical Industry. | yes |
26,848,743 | Does irradiation decrease the Neuroendocrine Biomarker Pro-Opiomelanocortin in Small Cell Lung Cancer Cells In Vitro and In Vivo? | {
"contexts": [
"Small cell lung cancer (SCLC) is an extremely aggressive disease, commonly displaying therapy-resistant relapse. We have previously identified neuroendocrine and epithelial phenotypes in SCLC tumours and the neuroendocrine marker, pro-opiomelanocortin (POMC), correlated with worse overall surviva... | In summary, POMC biomarker expression and secretion were reduced in SCLC tumours which regrew after irradiation and in repeatedly irradiation (irradiation-primed) cells. Therefore, POMC was no longer predictive of tumour burden. This highlights the importance of fully evaluating biomarkers during and after therapy to a... | yes |
26,877,612 | Does interleukin-22 contribute to liver regeneration in mice with concanavalin A-induced hepatitis after hepatectomy? | {
"contexts": [
"To investigate the therapeutic effects and mechanisms of interleukin (IL)-22 in liver regeneration in mice with concanavalin A (ConA)-induced liver injury following 70% hepatectomy.",
"Mice were injected intravenously with ConA at 10 μg/g body weight 4 d before 70% hepatectomy to create a hep... | In this study, we demonstrated that IL-22 is a survival factor for hepatocytes and prevents and repairs liver injury by enhancing pro-growth pathways via STAT3 activation. Treatment with IL-22 protein may represent a novel therapeutic strategy for preventing liver injury in patients with liver disease who have undergon... | yes |
26,877,618 | Does minimizing tacrolimus decrease the risk of new-onset diabetes mellitus after liver transplantation? | {
"contexts": [
"To investigate the impact of minimum tacrolimus (TAC) on new-onset diabetes mellitus (NODM) after liver transplantation (LT).",
"We retrospectively analyzed the data of 973 liver transplant recipients between March 1999 and September 2014 in West China Hospital Liver Transplantation Center. F... | A minimal TAC regimen can decrease the risk of long-term NODM after LT. Maintaining a cTAC value below 5.89 ng/mL after LT is safe and beneficial. | yes |
26,872,890 | Does intestine-specific homeobox ( ISX ) induce intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis? | {
"contexts": [
"Helicobacter pylori induces chronic inflammation and intestinal metaplasia (IM) through genetic and epigenetic changes and activation of intracellular signaling pathways that contribute to gastric carcinogenesis. However, the precise mechanism of IM in gastric carcinogenesis has not been fully el... | ISX expression induced by H. pylori infection may lead to IM and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis. | yes |
26,874,027 | Is metformin-induced protection against oxidative stress associated with AKT/mTOR restoration in PC12 cells? | {
"contexts": [
"Reactive oxygen species have been recognized to impair cell function through suppressing Akt the well-known pro-survival molecule. Pile of concrete evidence imply metformin as an Insulin sensitizer may enhance Akt/mTOR activity however the significance of Akt/mTOR recruitment has not yet been rev... | Taken together our experimentation supports the hypothesis that Akt/mTOR/S6K cascade may contribute to metformin alleviating effect. The present work while highlighting metformin anti-oxidant characteristics, concludes that Akt/mTOR signaling might be central to the drug's alleviating effects. | yes |
26,874,029 | Does nOD2 contribute to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and inflammation? | {
"contexts": [
"Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), an intracellular pattern recognition receptor, which plays an important role in the innate immunity and inflammation. However, its role in myocardial ischemia/reperfusion (I/R) injury remains unknown. In this study, we sought ... | NOD2 aggravates myocardial I/R injury by inducing cardiomyocyte apoptosis and inflammation through JNK, p38MAPK and NF-κB signaling pathways. This study provides insight into better understanding the molecular mechanism of NOD2, which may be served as a potential target for the treatment of myocardial I/R injury. | yes |
26,849,376 | Is expression of 58-kD Microspherule Protein ( MSP58 ) Highly Correlated with PET Imaging of Tumor Malignancy and Cell Proliferation in Glioma Patients? | {
"contexts": [
"The nucleolar 58-kDa microspherule protein (MSP58) has important transcriptional regulation functions and plays a crucial role in the tumorigenesis and progression of cancers. 3'-deoxy-3'-[18F]fluorothymidine (FLT) has emerged as a promising positron emission tomography (PET) tracer for evaluatin... | These results indicate that MSP58 plays an important role in cell proliferation and will be one of the potential candidates of molecular therapy targeting proliferation. FLT-PET might be used as an early measure of treatment response in the proliferation-targeted therapy. | yes |
26,876,000 | Is indices of dietary fat quality during midpregnancy associated with gestational diabetes? | {
"contexts": [
"To investigate the relationship between gestational diabetes mellitus (GDM) and the usual intake of fatty acids and indices of dietary fat quality [the atherogenicity (AI) and thrombogenicity indices (TI), and the ratios of hypo-and hypercholesterolemic (hH), ∑n-3/∑n-6, and polyunsaturated/satura... | The quality of dietary fat during pregnancy is strongly associated with GDM. Randomized clinical trial are needed to confirm these findings. | yes |
26,853,899 | Is dementia in Parkinson 's disease associated with enhanced mitochondrial complex I deficiency? | {
"contexts": [
"Dementia is a common feature of Parkinson's disease (PD), but the neuropathological changes associated with the development of Parkinson's disease dementia (PDD) are only partially understood. Mitochondrial dysfunction is a hallmark of PD but has not been studied in PDD.",
"Molecular and bioc... | Patients with PDD have a deficiency in mitochondrial complex I activity and reduced mitochondrial DNA levels in the prefrontal cortex without a change in mitochondrial protein quantity. Therefore, mitochondrial complex I deficiency and reduced mitochondrial DNA in the prefrontal cortex may be a hallmark of dementia in ... | yes |
26,865,218 | Does quercetin mitigate valinomycin-induced cellular stress via stress-induced metabolism and cell uptake? | {
"contexts": [
"Intestinal cells are constantly exposed to luminal toxins. In this study, we investigated the effect of cellular stress caused by valinomycin, which is structurally and functionally similar to the bacterial toxin cereulide, on quercetin metabolism and cellular localization in undifferentiated cel... | This is the first report on the change in metabolism, localization, and accumulation of O-methylated quercetin metabolites in undifferentiated Caco-2 cells as a response during stress caused by valinomycin. These results indicate a potential cellular stress response mechanism in undifferentiated Caco-2 cells, which add... | yes |
26,870,791 | Does bET Bromodomain Blockade mitigate Intimal Hyperplasia in Rat Carotid Arteries? | {
"contexts": [
"Intimal hyperplasia is a common cause of many vasculopathies. There has been a recent surge of interest in the bromo and extra-terminal (BET) epigenetic \"readers\" including BRD4 since the serendipitous discovery of JQ1(+), an inhibitor specific to the seemingly undruggable BET bromodomains. The... | Blocking BET bromodomains mitigates neointima formation, suggesting an epigenetic approach for effective prevention of intimal hyperplasia and associated vascular diseases. | yes |
26,871,449 | Does pretreatment Gastric Lavage reduce Postoperative Bleeding after Endoscopic Submucosal Dissection for Gastric Neoplasms? | {
"contexts": [
"For patients receiving endoscopic submucosal dissection (ESD), there is urgent need pertaining to the prevention of postoperative bleeding. We conducted a retrospective propensity score-matched study that evaluated whether pre-ESD gastric lavage prevents postoperative bleeding after ESD for gastr... | Pretreatment gastric lavage reduced postoperative bleeding in patients receiving ESD for gastric neoplasm. | yes |
26,855,926 | Does the Colonoscopist 's Expertise affect the Characteristics of Detected Polyps? | {
"contexts": [
"The influence of the endoscopist on the polyp detection rate (PDR) is underappreciated in clinical practice. Moreover, flat lesions or lesions of the proximal colon are more difficult to detect. Here, we evaluated the differences in the PDR and the characteristics of detected polyps according to ... | Our study demonstrated that the quality of a colonoscopy, measured by using the PDR, may increase when performed by experienced fellows. | yes |
26,857,246 | Is increased CSF tau level correlated with decreased lamina cribrosa thickness? | {
"contexts": [
"This study was to investigate whether the previously proposed link between Alzheimer's disease (AD) and decreased retinal nerve fiber layer thickness could be explained by the relationship between abnormal CSF profiles and optic nerve head characteristics, focusing on the influence of CSF tau pro... | An increased CSF level of T-tau was significantly associated with a thinner LCT in both the healthy and AD groups. This result suggests that LCT could serve as a potential non-invasive indicator for increased CSF tau. The clinical meaning of the higher level of CSF T-tau in axonal degeneration of the optic nerve remain... | yes |
26,864,308 | Does iL-33 mediate reactive eosinophilopoiesis in response to airborne allergen exposure? | {
"contexts": [
"Exposure to aeroallergens induces eosinophilic airway inflammation in patients with asthma and allergic airway diseases. The circulating number of eosinophils in peripheral blood is relatively small, leading us to hypothesize that bone marrow needs to be engaged quickly to meet the demands of the... | These finding suggests that lung IL-33, through innate activation of ILC2s and their production of IL-5, plays a key role in promoting acute reactive eosinophilopoiesis in the bone marrow when naïve animals are exposed to airborne allergens. Therefore, bone marrow eosinophilopoiesis may be affected by atmospheric envir... | yes |
26,864,306 | Does far-infrared promote burn wound healing by suppressing NLRP3 inflammasome caused by enhanced autophagy? | {
"contexts": [
"Understanding the underlying molecular mechanisms in burn wound progression is crucial to providing appropriate diagnoses and designing therapeutic regimens for burn patients. When inflammation becomes unregulated, recurrent, or excessive, it interferes with burn wound healing. Autophagy, which i... | Far-infrared (FIR) induced autophagy in THP-1 macrophages. FIR suppressed the NLRP3 inflammasome through the activation of autophagy. FIR induced the ubiquitination of ASC by increasing TRAF6. FIR ameliorated burn wound progression and promoted wound healing in a rat burn model. | yes |
26,855,612 | Try ' I to bother the residents too much ' - the use of capillary blood glucose measurements in nursing homes? | {
"contexts": [
"Capillary blood glucose measurements are regularly used for nursing home residents with diabetes. The usefulness of these measurements relies on clear indications for use, correct measurement techniques, proper documentation and clinical use of the resulting blood glucose values. The use of a reg... | Inadequate procedures and training in diabetes care may compromise the rationale for capillary blood glucose measurements in nursing homes, and hence the residents' safety. These concerns should be addressed together with the possibility of involving and empowering residents by exploring their ability and wish to manag... | no |
26,851,753 | Is 5-Hydroxymethylcytosine expression associated with poor survival in cervical squamous cell carcinoma? | {
"contexts": [
"Deoxyribonucleic acid methylation is an important epigenetic modification that is frequently altered in cancer. Recent reports showed that the level of 5-hydroxymethylcytosine was altered in various types of cancers. The influence of deoxyribonucleic acid methylation in cervical squamous cell car... | In cervical squamous cell carcinoma, less aggressive tumor behavior was correlated with 5-hydroxymethylcytosine and TET2. Our data indicated that 5-hydroxymethylcytosine may become a prognostic marker for cervical squamous cell carcinoma and the decreased expression of TET2 may be an underlying mechanism for decreased ... | yes |
26,859,314 | Are cRM1 and chromosomal passenger complex component survivin essential to normal mitosis progress and to preserve keratinocytes from mitotic abnormalities? | {
"contexts": [
"Human epidermis provides the body a barrier against environmental assaults. To assume this function, the epidermis needs the renewal of keratinocytes allowed by constant mitosis, which replace the exfoliating corneocytes. Keratinocyte stem cells (KSCs) located in the basal epidermis are mitotical... | Basal keratinocytes may divide frequently during skin lifespan, and signs of deterioration could appear such as loss of protein factors required for correct mitosis. Our findings suggest that mitotic abnormalities can be prevented by the modulation of CRM1 and survivin. We demonstrated the ability of compound 'IV08.009... | yes |
26,874,542 | Do myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion? | {
"contexts": [
"High arginase-1 (Arg) expression by myeloid-derived suppressor cells (MDSC) is known to inhibit antitumor T-cell responses through depletion of l-arginine. We have previously shown that nitric oxide (NO), an immune mediator produced from l-arginine, is a potent radiosensitizer of hypoxic tumor ce... | Protumor Arg(+) MDSC reveal a unique ability to radioprotect tumor cells through l-arginine depletion, a common mechanism behind both T-cell and macrophage inhibition. | yes |
26,856,608 | Does comparison of creatinine clearance estimate in subgroups based on Body Mass Index and albumin? | {
"contexts": [
"The establishment of accurate equations for glomerular filtration rate (GFR) estimations is still far from the realization. Factors such as age, diabetes, stage of CKD, pregnancy, muscle mass and ethic nation are associated with less reliance upon commonly utilized estimation equations. We aimed ... | CG gave a better prediction of measured CrCl than MDRD in Mediterranean, non-diabetic, non-hospitalized patients although misclassification of patients with regard to renal impairment stage was not present. | yes |
26,851,383 | Does walking-induced muscle fatigue impair postural control in adolescents with unilateral spastic cerebral palsy? | {
"contexts": [
"Fatigue is likely to be an important limiting factor in adolescents with spastic cerebral palsy (CP).",
"To determine the effects of walking-induced fatigue on postural control adjustments in adolescents with unilateral CP and their typically developing (TD) peers.",
"Ten adolescents with... | Unlike TD adolescents, treadmill walking for 15 min at their preferred speed lead to significant knee extensor strength losses and impairments in postural control in adolescents with unilateral spastic CP. | yes |
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