pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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26,851,245 | Does calmodulin kinase II inhibition limit the pro-arrhythmic Ca2+ waves induced by cAMP-phosphodiesterase inhibitors? | {
"contexts": [
"A major concern of using phosphodiesterase (PDE) inhibitors in heart failure is their potential to increase mortality by inducing arrhythmias. By diminishing cyclic adenosine monophosphate (cAMP) hydrolysis, they promote protein kinase A (PKA) activity under β-adrenergic receptor (β-AR) stimulati... | Our results show that PDE inhibitors exert inotropic effects via PKA but lead to SCWs via both PKA and CaMKII activation partly via Epac2, suggesting the potential use of CaMKII inhibitors as adjuncts to PDE inhibition to limit their pro-arrhythmic effects. | yes |
26,871,588 | Is vitamin D deficiency associated with prediabetes in obese Swedish children? | {
"contexts": [
"Low vitamin D levels have been associated with obesity and living in areas that lack sunshine, such as northern Europe. The aim of this study was to investigate the vitamin D status of a group of obese children in Sweden and to investigate the associations between vitamin D status and markers of ... | Low vitamin D levels were common among obese adolescents living in Sweden and were strongly associated with age and associated with a higher risk of IFG. | yes |
26,872,722 | Does fluoxetine-induced toxicity result in human placental glutathione S-transferase-π ( GST-π ) dysfunction? | {
"contexts": [
"The antidepressant drug fluoxetine (FLU) is considered in the group of selective serotonine re-uptake inhibitors. Its distribution in brain and binding to human brain glutathione S-transferase-π (GST-π) have been shown. FLU can cross blood brain barrier and placenta, accumulate in fetus and may c... | Although the Ki values obtained for FLU in vitro are high, due to their uneven distribution, long elimination time and inhibitory behavior on detoxification systems, it may cause defects in adults but these effects may be much more severe in fetus and result in congenital malformations. | yes |
26,876,380 | Does virus-mediated EpoR76E gene therapy preserve vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress? | {
"contexts": [
"Glaucoma is a complex neurodegeneration and a leading cause of blindness worldwide. Current therapeutic strategies, which are all directed towards lowering the intraocular pressure (IOP), do not stop progression of the disease. We have demonstrated that recombinant adeno-associated virus (rAAV) g... | Treatment with rAAV.EpoR76E preserves vision in the DBA/2J model of glaucoma at least in part by decreasing infiltration of peripheral immune cells, modulating microglial reactivity, and decreasing oxidative stress. | yes |
26,862,255 | Does preclinical Safety Assessment of Standardized Extract of Centella asiatica ( L. ) Urban leave? | {
"contexts": [
"Centella asiatica (CA) leaves extract has been shown therapeutic potential. However, safety information is lacking.",
"To evaluate acute oral toxicity (AOT), sub-chronic toxicity, and mutagenic potential of standardized extract of CA (L.) Urban leaves (INDCA).",
"For the acute toxicity st... | INDCA was found safe in AOT, sub-chronic toxicity, and mutagenicity studies when tested in rats. | yes |
26,862,256 | Does terminalia Chebula attenuate DMBA/Croton Oil-Induced Oxidative Stress and Inflammation in Swiss albino Mouse Skin? | {
"contexts": [
"The present study was designed to investigate underlying molecular mechanism for antitumorigenic potential of Terminalia chebula (TC) against chemically-induced skin tumorigenesis in Swiss albino mice. It is used as herbal medicine because it exhibits antioxidant, anti-inflammatory, and anticarci... | The findings of the present study suggest that the chemopreventive effect of TC is associated with upregulation of endogenous cytoprotective machinery and downregulation of inflammatory mediators (interleukin (IL)-6, COX-2, i-NOS, ODC, and NF-κB). | yes |
26,868,440 | Do ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans? | {
"contexts": [
"Recent studies suggest that air pollution plays a role in type 2 diabetes (T2D) incidence and mortality. The underlying physiological mechanisms have yet to be established. We hypothesized that air pollution adversely affects insulin sensitivity and secretion and serum lipid levels.",
"Partic... | Exposure to ambient air pollutants adversely affects glucose tolerance, insulin sensitivity, and blood lipid concentrations. Our findings suggest that ambient air pollutants may contribute to the pathophysiology in the development of T2D and related sequelae. | yes |
26,864,570 | Does pTSD REMISSION AFTER PROLONGED EXPOSURE TREATMENT be ASSOCIATED WITH ANTERIOR CINGULATE CORTEX THINNING AND VOLUME REDUCTION? | {
"contexts": [
"Brain structures underlying posttraumatic stress disorder (PTSD) have been a focus of imaging studies, but associations between treatment outcome and alterations in brain structures remain largely unexamined. We longitudinally examined the relation of structural changes in the rostral anterior ci... | These results, while in need of replication, suggest that PE treatment for PTSD, by extinguishing maladaptive trauma associations, may promote synaptic plasticity and structure change in rACC. Future research should explore possible underlying mechanisms. | yes |
26,866,650 | Does molecular hydrogen alleviate motor deficits and muscle degeneration in mdx mice? | {
"contexts": [
"Duchenne muscular dystrophy (DMD) is a devastating muscle disease caused by a mutation in DMD encoding dystrophin. Oxidative stress accounts for dystrophic muscle pathologies in DMD. We examined the effects of molecular hydrogen in mdx mice, a model animal for DMD.",
"The pregnant mother star... | Although molecular mechanisms of the diverse effects of hydrogen remain to be elucidated, hydrogen potentially improves muscular dystrophy in DMD patients. | yes |
26,849,431 | Does age-Related Decline of Neutrophilic Inflammation be Associated with Better Postoperative Prognosis in Non-eosinophilic Nasal Polyps? | {
"contexts": [
"Innate and adaptive immune responses change with increasing age and affect the course of diseases. Previous study investigated immunologic alteration in Western nasal polyps (NP) which is mostly eosinophilic. However, there are no reports regarding age-related immune changes of non-eosinophilic N... | Age-related decline in neutrophil inflammation may favorably affect postoperative results in elderly patients with NE-NP. | yes |
26,873,794 | Does core muscle recruitment pattern during voluntary heel raise is different between patients with patellofemoral pain and healthy individuals? | {
"contexts": [
"Recent studies suggest that the inconsistent outcomes of patellofemoral pain (PFP) treatment may result from the unclear understanding of changes in the structures remote from the knee joint. Due to the crucial influence of core stability on the knee function, this study aimed to evaluate the rec... | The findings demonstrate that muscular stabilization of spine is altered in the presence of PFP and suggest that treatment techniques aimed at improving core stability could be appropriate in the management of PFP. | yes |
26,874,268 | Does gH response to intravenous clonidine challenge correlate with history of childhood trauma in personality disorder? | {
"contexts": [
"Childhood trauma is a risk factor for personality disorder. We have previously shown that childhood trauma is associated with increased central corticotrophin-releasing hormone concentration in adults with personality disorder. In the brain, the release of corticotrophin-releasing hormone can be ... | Childhood trauma is positively correlated with GH response to clonidine challenge in adults with personality disorder. Enhanced rather that blunted GH response differentiates childhood trauma from previously identified negative predictors of GH response, such as anxiety or mood disorder. | yes |
26,872,365 | Does miR-214 attenuate Osteogenic Differentiation of Mesenchymal Stem Cells via Targeting FGFR1? | {
"contexts": [
"Postmenopausal osteoporosis is closely associated with reduction in the differentiation of mesenchymal stem cells (MSCs) into osteoblasts. Previous studies have demonstrated that miR-214 plays an important role in the genesis and development of postmenopausal osteoporosis. Here, we performed this... | MiR-214 attenuates osteogenesis by inhibiting the FGFR1/FGF signaling pathway. Our findings suggest that targeting miR-214 promises to be a potential therapy in treatment of postmenopausal osteoporosis. | yes |
26,872,366 | Does tapered-cuff Endotracheal Tube Prevent Early Postoperative Pneumonia Compared with Spherical-cuff Endotracheal Tube after Major Vascular Surgery : A Randomized Controlled Trial? | {
"contexts": [
"Patients undergoing major vascular surgery often develop postoperative pneumonia that impacts their outcomes. Conflicting data exist concerning the potential benefit of tapered-shaped cuffs on tracheal sealing. The primary objective of this study was to assess the efficiency of a polyvinyl chlori... | For major vascular surgery patients, polyvinyl chloride tapered-cuff endotracheal tubes with intermittent cuff-pressure control did not lower the early postoperative pneumonia frequency and did not prevent microaspiration. | no |
26,859,543 | Does intratympanic Iodine Contrast Injection diffuse Across the Round Window Membrane Allowing for Perilymphatic CT Volume Acquisition Imaging? | {
"contexts": [
"Whether the round window membrane (RWM) is permeable to iodine-based contrast agents (IBCA) is unknown; therefore, our goal was to determine if IBCAs could diffuse through the RWM using CT volume acquisition imaging.",
"Imaging of hydrops in the living human ear has attracted recent interest.... | Iohexol iodine contrast is able to diffuse across the RWM. Volume acquisition CT imaging was able to detect perilymphatic enhancement at 0.5-mm slice thickness. The clinical application of IBCA IT injection seems promising but requires further safety studies. | yes |
26,873,343 | Is up-regulation of TDAG51 a dependent factor of LPS-induced RAW264.7 macrophages proliferation and cell cycle progression? | {
"contexts": [
"As a component of the outer membrane in Gram-negative bacteria, lipopolysaccharide (LPS)-induced proliferation and cell cycle progression of monocytes/macrophages. It has been suggested that the proapoptotic T-cell death-associated gene 51 (TDAG51) might be associated with cell proliferation and ... | These findings suggested that TDAG51 up-regulation is a dependent event during LPS-mediated proliferation and cell cycle progression, and which increase our understanding of the interaction mechanism between LPS and macrophages. | yes |
26,868,655 | Does ruminococcus gnavus E1 modulate mucin expression and intestinal glycosylation? | {
"contexts": [
"The molecular cross-talk between commensal bacteria and the gut play an important role in the maintenance of the intestinal homeostasis and general health. Here, we studied the impact of a major Gram-positive anaerobic bacterium of the human gut microbiota, that is, Ruminococcus gnavus on the gly... | This study demonstrates for the first time that R. gnavus E1 possess the ability to modulate the glycosylation profile of the glyco-conjugate molecules and mucus in goblet cells. | yes |
26,872,289 | Are diet , physical activity and mental health status associated with dysglycaemia in pregnancy : the Healthy Start Study? | {
"contexts": [
"To examine the association between dysglycaemia and multiple modifiable factors measured during pregnancy.",
"The Healthy Start Study collected self-reported data on modifiable factors in early and mid-pregnancy (median 17 and 27 weeks gestation, respectively) from 832 women. Women received o... | An increasing number of positive modifiable factors in pregnancy was associated with a dose-response reduction in risk of dysglycaemia. Our results support the hypothesis that modifiable factors in pregnancy are associated with the risk of prenatal dysglycaemia. | yes |
26,870,663 | Are mutations in the Mitochondrial Citrate Carrier SLC25A1 Associated with Impaired Neuromuscular Transmission? | {
"contexts": [
"Congenital myasthenic syndromes are rare inherited disorders characterized by fatigable weakness caused by malfunction of the neuromuscular junction. We performed whole exome sequencing to unravel the genetic aetiology in an English sib pair with clinical features suggestive of congenital myasthe... | Based on the axonal outgrowth defects seen in SLC25A1 knockdown zebrafish, we hypothesize that the neuromuscular junction impairment may be related to pre-synaptic nerve terminal abnormalities. Our findings highlight the complex machinery required to ensure efficient neuromuscular function, beyond the proteomes exclusi... | yes |
26,850,203 | Does more compression improve sealing effect on larger pulmonary arteries? | {
"contexts": [
"Small arteries and veins up to 7 mm can be sealed safe and divided with a bipolar sealing instrument. The results for the safe sealing of larger vessels were unsatisfactory in the past. Using an ex vivo pulmonary artery model, we aimed to investigate, if a higher compression force and duration wi... | With a higher compression force, we reached satisfactory bursting pressures in case of pulmonary arteries >7 mm. An additional 5 s of compression before starting coagulation brings a further significant increase in bursting pressure. However, there is no advantage in a longer compression. | yes |
26,863,137 | Do prestroke Antiplatelet Agents in First-Time Ischemic Stroke Are Related to Subtypes? | {
"contexts": [
"It is not well known whether prestroke antiplatelet agents (PAs) are associated with the subtypes of ischemic stroke.",
"We screened patients in a hospital-based stroke registry. Patients who were admitted with a diagnosis of first-time ischemic stroke within 5 days of symptom onset were incl... | PAs were associated with specific index stroke subtypes. | yes |
26,861,116 | Does methylene blue attenuate mitochondrial dysfunction of rat kidney during experimental acute pancreatitis? | {
"contexts": [
"The disturbance of mitochondrial functions has been considered as one of the mechanisms of pathogenesis of acute pancreatitis (AP) followed by kidney failure. This study was aimed to investigate the effects of methylene blue (MB) on pancreas and kidney mitochondrial respiratory functions during e... | The disturbances of kidney mitochondrial energy metabolism in experimental model of severe AP can be ameliorated by MB administration. | yes |
26,864,355 | Is plasma trimethylamine N-oxide concentration associated with choline , phospholipids , and methyl metabolism? | {
"contexts": [
"Elevated plasma concentrations of the gut bacteria choline metabolite trimethylamine N-oxide (TMAO) are associated with atherosclerosis. However, the determinants of TMAO in humans require additional assessment.",
"We examined cardiometabolic risk factors and pathways associated with TMAO con... | High TMAO and choline concentrations are associated with an advanced cardiometabolic risk profile. Diabetes is related to higher plasma TMAO concentrations but also to alterations in interrelated pathways such as lipids, phospholipids, and methylation. Elevated plasma TMAO concentrations likely reflect a specific metab... | yes |
26,867,675 | Does tGF-beta1 regulate human brain pericyte inflammatory processes involved in neurovasculature function? | {
"contexts": [
"Transforming growth factor beta 1 (TGFβ1) is strongly induced following brain injury and polarises microglia to an anti-inflammatory phenotype. Augmentation of TGFβ1 responses may therefore be beneficial in preventing inflammation in neurological disorders including stroke and neurodegenerative d... | TGFβ1 attenuated pericyte expression of key chemokines and adhesion molecules involved in CNS leukocyte trafficking and the modulation of microglial function, as well as reduced the phagocytic ability of pericytes. However, TGFβ1 also enhanced the expression of classical pro-inflammatory cytokines and enzymes which can... | yes |
26,867,677 | Is bloating associated with worse quality of life , treatment satisfaction , and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation? | {
"contexts": [
"The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes.",
"Thirty-nine centers for functional gastrointe... | Our data suggest that patients regard bloating as a key element in assessing clinical changes and treatments' efficacy as this symptom exerts a strong influence on patient-reported outcomes independent of possible confounders and other symptoms of constipation. Our data provide the rationale to investigate the efficacy... | yes |
26,855,845 | Is fall Risk Black and White? | {
"contexts": [
"To determine whether previously reported racial differences in fall rates between White and Black/African American is explained by differences in health status and neighborhood characteristics.",
"Prospective cohort.",
"Community.",
"The study included 550 White and 116 Black older ad... | Our findings suggest that the racial differences in fall rates may be largely due to confounding by individual-level and community-level characteristics. | no |
26,859,365 | Does baroreflex dysfunction in sick newborns make heart rate an unreliable surrogate for blood pressure changes? | {
"contexts": [
"Cerebral pressure passivity (CPP) in sick newborns can be detected by evaluating coupling between mean arterial pressure (MAP) and cerebral blood flow measured by near infra-red spectroscopy hemoglobin difference (HbD). However, continuous MAP monitoring requires invasive catheterization with its... | In these sick newborns, HR was an unreliable surrogate for MAP required for the detection of CPP. This is likely due to the prevalence of BRF failure in these infants. | yes |
26,870,715 | Do galectin-3 Serum Levels Are Independently Associated With Microalbuminuria in Chronic Heart Failure Outpatients? | {
"contexts": [
"Galectin-3 (Gal-3) is a novel biomarker reflecting inflammation status and fibrosis involving worsening of both cardiac and renal functions.",
"The aim of this study was to evaluate the relationship between Gal-3 serum levels and microalbuminuria in a group of chronic heart failure (CHF) outp... | Our findings indicate an independent association between Gal-3 levels and microalbuminuria, an early marker of altered renal function. This suggests the possible role of Gal-3 in the progression of cardiorenal syndrome in CHF outpatients. | yes |
26,850,720 | Does single amino acid substitution Gly186Val in AdeS restore tigecycline susceptibility of Acinetobacter baumannii? | {
"contexts": [
"Amino acid substitutions within the AdeRS two-component system are believed to result in overexpression of the AdeABC efflux pump and extensive resistance to antibiotics in clinical Acinetobacter baumannii isolates. However, the exact amino acid substitutions in AdeRS that cause overexpression of... | Our result demonstrates that a critical amino acid substitution in AdeS alters the AdeABC efflux pump-mediated tigecycline resistance of A. baumannii. | yes |
26,872,427 | Do aGEs trigger autophagy in diabetic skin tissues and fibroblasts? | {
"contexts": [
"Accumulation of advanced glycation end products (AGEs) contributes to the development of diabetic ulcers. Recent evidence indicates that AGEs administration enhanced autophagy in many cell types. As a positive trigger of autophagy, the effect of AGEs on autophagy in skin tissues and fibroblasts r... | AGEs could induce autophagy at least in part via regulating the FOXO1 activity in diabetic skin tissues and fibroblasts. | yes |
26,879,355 | Does early Remission be a Realistic Target in a Majority of Patients with DMARD-naive Rheumatoid Arthritis? | {
"contexts": [
"We analyzed remission rates at 3 and 12 months in patients with rheumatoid arthritis (RA) who were naive for disease-modifying antirheumatic drugs (DMARD) and who were treated in a Finnish rheumatology clinic from 2008 to 2011. We compared remission rates and drug treatments between patients with... | Remarkably high remission rates are achievable in real-world DMARD-naive patients with RA or UA. | yes |
26,859,875 | Does emulsified Isoflurane protect Against Transient Focal Cerebral Ischemia Injury in Rats via the PI3K/Akt Signaling Pathway? | {
"contexts": [
"Phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) pathway activation may promote neuronal survival via neuroprotection during inflammation after cerebral ischemia. In this study, we investigated whether IV pretreatment with emulsified isoflurane (EI) could decrease ischemic brain injury rel... | These findings suggest that EI pretreatment protects against ischemic brain injury via the inhibition of cerebral inflammation and is associated with the PI3K-Akt pathway in rats with MCAO. This drug may be a novel therapeutic agent for patients after stroke. | yes |
26,861,675 | Does d-Serine in the nucleus accumbens region modulate behavioral sensitization and extinction of conditioned place preference? | {
"contexts": [
"D-serine, the endogenous co-agonist of N-methyl-D-aspartate receptors (NMDARs), is considered to be essential for learning and memory. The aim of the current investigation was to systematically evaluate the role of D-serine on addiction behaviors considered to be mediated by the nucleus accumbens... | Our results provide evidence for a critical role of D-serine in synaptic plasticity relevant to cocaine addiction and indicate that D-serine may be an effective therapeutic agent for cocaine addiction. | yes |
26,849,796 | Does optical Coherence Tomographic Elastography reveal Mesoscale Shear Strain Inhomogeneities in the Annulus Fibrosus? | {
"contexts": [
"Basic science study using in vitro tissue testing and imaging to characterize local strains in annulus fibrosus (AF) tissue.",
"To characterize mesoscale strain inhomogeneities between lamellar and inter-/translamellar (ITL) matrix compartments during tissue shear loading.",
"The interver... | Results from this study demonstrate that the lamellar and ITL compartments of the AF distribute strain unevenly during tissue loading. Specifically, shear strain is significantly higher in the ITL matrix, suggesting that these regions may be more susceptible to tissue damage and more mechanobiologically active. | yes |
26,848,443 | Does cephalometric Angular Measurements of the Mandible Using Three-Dimensional Computed Tomography scan in Koreans? | {
"contexts": [
"We conducted this study to analyze the values of the key cephalometric angular measurements of the mandible using 3-dimensional (3D) computed tomography scans.",
"In the 106 enrolled patients, a 3D cephalometric analysis was performed to measure the angular variables of the mandible. These va... | These results provide an average of the mandibular angular measurements for the Korean population, establishing a standard for determining surgical patient groups and outcome evaluations in the field of mandible contour surgery. | yes |
26,848,449 | Do analysis of 344 Hand Injuries in a Pediatric Population? | {
"contexts": [
"The purpose of this study was to identify comprehensive hand injury patterns in different pediatric age groups and to assess their risk factors.",
"This retrospective study was conducted among patients younger than 16-year-old who presented to the emergency room of a general hospital located ... | This study provides a comprehensive overview of the epidemiology of hand injuries in the pediatric population. | yes |
26,867,705 | Is online information for women and their families regarding reduced fetal movements of variable quality , readability and accountability? | {
"contexts": [
"reduced fetal movements (RFM) are experienced by 46-50% of women prior to the diagnosis of stillbirth. Empowering women with evidenced-based information regarding RFM may allow for prompt contact with a health care provider and access to appropriate management. Use of the Internet is growing in p... | overall, there was wide variation in the quality of information regarding RFM on the Internet. However, the study identified four excellent websites on RFM that may be suitable sources of information for women. Women׳s uncertainty displayed in the chat forums may suggest that clearer, accessible guidance is needed if t... | yes |
26,852,322 | Is human endogenous retrovirus ( HERV ) expression induced by treatment with the histone deacetylase ( HDAC ) inhibitors in cellular models of HIV-1 latency? | {
"contexts": [
"While antiretroviral therapies have improved life expectancy and reduced viral loads in HIV-1-positive individuals, the cessation of treatment results in a rebound of viral replication. This suggests that a reservoir of latently-infected cells remains within these patients, the identity of which ... | We show that HDAC inhibitors did not substantially increase the transcription of the analysed HERV env or pol genes, suggesting that histone acetylation is not crucial for controlling HERV expression in these experimental models and in ex vivo primary human T cells. Importantly, this indicates that unwanted HERV expres... | no |
26,858,195 | Is amino Acid Metabolism Altered in Adolescents with Nonalcoholic Fatty Liver Disease-An Untargeted , High Resolution Metabolomics Study? | {
"contexts": [
"To conduct an untargeted, high resolution exploration of metabolic pathways that was altered in association with hepatic steatosis in adolescents.",
"This prospective, case-control study included 39 Hispanic-American, obese adolescents aged 11-17 years evaluated for hepatic steatosis using ma... | Metabolic pathways of several amino acids are significantly disturbed in adolescents with elevated hepatic steatosis. This is a novel finding and suggests that these pathways may be integral in the mechanisms of NAFLD. | yes |
26,851,014 | Does polo-like Kinase Inhibitor Volasertib exhibit Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies? | {
"contexts": [
"Polo-like kinase 1 (PLK1) controls the main cell-cycle checkpoints, suggesting utility of its inhibition for cancer treatment, including of highly proliferative pediatric cancer. This preclinical study explored the selective PLK1 inhibitor volasertib (BI 6727) alone and combined with chemotherapy... | These findings support the further exploration of volasertib for pediatric malignancies, particularly alveolar rhabdomyosarcoma, and its combination with mitotic spindle poison. | yes |
26,851,010 | Does hSV-1 Infection modulate the Radioresponse of a HPV16-positive Head and Neck Cancer Cell Line? | {
"contexts": [
"The combined effects of Human papillomavirus (HPV) and Herpes simplex type 1 (HSV-1) infections and their effects on cancer cell radioresistance are unexplored.",
"An HPV16-positive hypopharyngeal carcinoma cell line (UD-SCC-2) was infected with wt-HSV-1 at low multiplicity of infection (MOI)... | HSV-1 infection modulates radioresistance of HPV16-positive hypopharyngeal carcinoma cells. | yes |
26,851,186 | Does sTAT3/5-Dependent IL9 Overexpression contribute to Neoplastic Cell Survival in Mycosis Fungoides? | {
"contexts": [
"Sustained inflammation is a key feature of mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL). Resident IL9-producing T cells have been found in skin infections and certain inflammatory skin diseases, but their role in MF is currently unknown.",
"We analyzed lesi... | Our results suggest that IL9 and its regulators are promising new targets for therapy development in mycosis fungoides. Clin Cancer Res; 22(13); 3328-39. ©2016 AACR. | yes |
26,852,066 | Is familial dilated cardiomyopathy diagnosis commonly overlooked at the time of transplant listing? | {
"contexts": [
"The prevalence and clinical characteristics of familial dilated cardiomyopathy (FDCM) among patients with end stage heart failure (ESHF) has yet to be elucidated. We sought to determine the prevalence of FDCM in ESHF in the United Network for Organ Sharing (UNOS) registry and compare this with ce... | The diagnosis of FDCM was missed in the majority of patients with end stage heart failure enrolled in the UNOS database, as sampled from a large, tertiary care teaching hospital in the United States. Echocardiographic findings are unlikely to aid in the differentiation between DCM and FDCM. Detailed pedigree analysis c... | yes |
26,865,177 | Are fGF-23 levels associated with vascular calcification , but not with atherosclerosis , in hemodialysis patients? | {
"contexts": [
"High fibroblast growth factor-23 (FGF-23) levels are associated with mortality and cardiovascular events in patients with chronic kidney disease. The aim of this cross-sectional study was to investigate the relationship between plasma FGF-23 levels and coronary artery calcification and carotid ar... | In HD patients, plasma FGF-23 level is superior to phosphate in the prediction of coronary artery calcification. However, FGF-23 is not associated with carotid artery atherosclerosis in HD patients. | yes |
26,860,290 | Does intraarticular hamstring graft diameter decrease with continuing knee growth after ACL reconstruction with open physes? | {
"contexts": [
"To evaluate the graft diameter size after one-year follow-up or more of patients Tanner II, III, and IV who were submitted to anterior cruciate ligament reconstruction.",
"Ten patients [five males (mean age: 14.4 years) and five females (mean age: 13.6 years)] with open physis and anterior cr... | Diameter size of hamstring graft in skeletally immature patients is smaller in most cases. If there is a decrease in the diameter of the graft along postoperative time, the risk of a re-rupture is theoretically further increased. Quadruple hamstring graft decreases a mean 25.3% in diameter from time of anterior cruciat... | yes |
26,861,463 | Does research consent capacity vary with executive function and memory in Parkinson 's disease? | {
"contexts": [
"We examined the association between cognitive domains and research consent capacity in PD. Our hypothesis was that research consent capacity is best predicted by executive function.",
"A cohort of 90 PD patients and 30 healthy older adults were administered the MacArthur Competence Assessment... | These results extend our previous findings by demonstrating that memory and executive abilities appear closely associated with capacity when evaluated using either a structured interview or expert judgment of that interview. | yes |
26,861,461 | Does sIRT6 Overexpression potentiate Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway? | {
"contexts": [
"To characterize the functional role of SIRT6 in hepatocellular carcinoma (HCC).",
"The expression of SIRT6 in 60 paired paraffin-embedded HCC tissues and adjacent nontumoral liver tissues was examined by immunohistochemistry. The expression of SIRT6 in 101 paired frozen HCC tissues and adjace... | SIRT6 is an important protumorigenic factor in liver carcinogenesis. Thus, the therapeutic targeting of SIRT6 may offer options for HCC treatment. Clin Cancer Res; 22(13); 3372-82. ©2016 AACR. | yes |
26,861,460 | Does reduced Expression of SMAD4 be Associated with Poor Survival in Colon Cancer? | {
"contexts": [
"SMAD4 loss is associated with the development of metastases and poor prognosis. We evaluated expression of SMAD4 protein and its association with tumor characteristics, including biomarkers and outcome in terms of relapse-free survival and overall survival.",
"We used 1,564 stage II/III colon... | We conclude that clonal loss of SMAD4 expression in adenomas, carcinomas, and liver metastases increases with disease progression. SMAD4 loss, and to a lesser extent weak expression, is strongly associated with poor survival regardless of stage. Clin Cancer Res; 22(12); 3037-47. ©2016 AACR. | yes |
26,876,441 | Do heat shock protein complex vaccines induce antibodies against Neisseria meningitidis via a MyD88-independent mechanism? | {
"contexts": [
"Neisseria meningitidis are common colonizers of the human nasopharynx. In some circumstances, N. meningitidis becomes an opportunistic pathogen that invades tissues and causes meningitis. While a vaccine against a number of serogroups has been in effective use for many years, a vaccine against N.... | N. lactamica and N. meningitidis HSPC vaccines both have potential utility for immunising against neisserial meningitis without the requirement for an exogenous adjuvant. The mode of action of these vaccines is highly complex, with HSPCs inducing immune responses via both MyD88-dependent and -independent mechanisms. In... | yes |
26,878,545 | Do prophylaxis against heterotopic ossification after elbow and acetabular fractures - Do we really need it? | {
"contexts": [
"To compare the efficacy and safety of prophylactic modalities for heterotopic ossification prevention after elbow and acetabular surgeries.",
"The retrospective chart review was conducted at the Aga Khan University Hospital and comprised record of patients who underwent open reduction and int... | No role of radiotherapy or indomethacin was detected in the prevention of heterotopic ossification. | yes |
26,856,684 | Does prostate cancer-derived cathelicidin-related antimicrobial peptide facilitate macrophage differentiation and polarization of immature myeloid progenitors to protumorigenic macrophages? | {
"contexts": [
"A growing body of evidence indicates a positive correlation between expression of human antimicrobial peptide leucin leucin 37 (LL-37) and progression of epithelial cancers, including prostate cancer (PCa). Although the molecular mechanisms for this correlation has not yet been elucidated, the pr... | Altogether, the present study suggests that overexpressed CRAMP in prostate tumor initially chemoattracts IMPs to TME and mediates differentiation and polarization of early myeloid progenitors into protumorigenic M2 macrophages during PCa progression. Thus, selective downregulation of CRAMP in tumor cells in situ may b... | yes |
26,859,150 | Does mechanical Stretch inhibit MicroRNA499 via p53 to Regulate Calcineurin-A Expression in Rat Cardiomyocytes? | {
"contexts": [
"MicroRNAs play an important role in cardiac remodeling. MicroRNA 499 (miR499) is highly enriched in cardiomyocytes and targets the gene for Calcineurin A (CnA), which is associated with mitochondrial fission and apoptosis. The mechanism regulating miR499 in stretched cardiomyocytes and in volume ... | The miR499-controlled apoptotic pathway involving CnA and Drp1 in stretched cardiomyocytes may be regulated by p53 through the transcriptional regulation of miR499. | yes |
26,853,140 | Are the D9N , N291S , and T495G Polymorphisms of the Lipoprotein Lipase Gene Associated with Cerebral Infarction? | {
"contexts": [
"Lipoprotein lipase (LPL) plays an important role in plasma lipoprotein metabolism and its polymorphisms are possibly implicated in the etiology of ischemic cerebrovascular disease (CVD). The aim of this work was to determine the association of the of D9N, N291S, and T495G polymorphisms of the LPL... | In the present study, the D9N, N291S, and T495G polymorphisms of the LPL gene were not risk factors for the development of CVD. | no |
26,858,166 | Does expression of microRNA-133 inhibit epithelial-mesenchymal transition in lung cancer cells by directly targeting FOXQ1? | {
"contexts": [
"MicroRNA (miR) was implicated in the tumorigenesis of many types of cancer, but no study was conducted on the exact role of miR-133 in lung cancer.",
"We have identified miR-133 as a putative regulator of FOXQ1 expression, and investigated the potential involvement of miR-133 in the migration... | Our study is the first to identify miR-133 as a biomarker for lung cancer. It functions to down-regulate FOXQ1, and inhibit epithelial-mesenchymal transition, which antagonizes lung cancer tumorigenesis. Therefore our data support the role of miR-133 as a potential molecular therapeutic tool in treating lung cancer. | yes |
26,857,698 | Does genome-wide DNA methylation analysis in multiple tissues in primary Sjögren 's syndrome reveal regulatory effects at interferon-induced genes? | {
"contexts": [
"Increasing evidence suggests an epigenetic contribution to the pathogenesis of autoimmune diseases, including primary Sjögren's Syndrome (pSS). The aim of this study was to investigate the role of DNA methylation in pSS by analysing multiple tissues from patients and controls.",
"Genome-wide ... | Our study highlights the role of epigenetic regulation of IFN-induced genes in pSS where replication is needed for novel findings. The association with altered gene expression suggests a functional mechanism for differentially methylated CpG sites in pSS aetiology. | yes |
26,878,385 | Does mTOR inhibition decrease SOX2-SOX9 mediated glioma stem cell activity and temozolomide resistance? | {
"contexts": [
"SOX2 and SOX9 are commonly overexpressed in glioblastoma, and regulate the activity of glioma stem cells (GSCs). Their specific and overlapping roles in GSCs and glioma treatment remain unclear.",
"SOX2 and SOX9 levels were examined in human biopsies. Gain and loss of function determined the ... | Our findings reveal SOX2-SOX9 as an oncogenic axis that regulates stem cell properties and chemoresistance. We identify that rapamycin abrogate SOX protein expression and provide evidence that a combination of rapamycin and temozolomide inhibits tumor growth in cells with high SOX2/SOX9. | yes |
26,854,434 | Do young age and pathological features predict breast cancer outcome - report from a dual Institution experience in Serbia? | {
"contexts": [
"The aim of this study was to investigate the influence of clinicopathological and biological characteristics on prognosis, disease free survival (DFS) and overall survival (OS), of very young patients (≤35 years of age) with breast cancer.",
"We retrospectively collected information of 150 wo... | Diagnosis of breast cancer at very young age (<30) was associated with increased risk of death and shorter DFS than women aged 31-35. Negative impact on survival was seen in patients with presence of LVI, negative HRs and higher grade and stage at the time of presentation. | yes |
26,854,437 | Are erythropoietin receptor and tissue factor coexpressed in human breast cancer cells? | {
"contexts": [
"Erythropoiesis-stimulating agents (ESAs) are recommended for treating chemotherapy-induced anemia in breast cancer patients. Reduced survival rates in ESAs-treated patients have been reported, possibly due to thromboembolic complications, however the exact mechanism remains obscure. The principal... | EPO-R and TF expression and their coexpression in breast cancer cells suggest a possibility that EPO-R might be responsible for some adverse effects and reduced survival observed in ESAs-treated breast cancer patients with anemia, possibly due to the interaction with TF. Further experimental studies are warranted to de... | yes |
26,860,872 | Is activation of zebrafish Src family kinases by the prion protein an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo? | {
"contexts": [
"Prions and amyloid-β (Aβ) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, PrP-1-dependent signals control cell-cell adhesion via a tyrosine phosphorylation-dependent mechan... | Our gain- and loss-of-function experiments in zebrafish suggest that PrP and SFKs enhance the cell surface stability of embryonic adherens junctions via the same complex mechanism through which they over-activate neuroreceptors that trigger synaptic damage. The profound impact of this pathway on early zebrafish develop... | yes |
26,861,252 | Does polyphyllin VII induce apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways? | {
"contexts": [
"Paris polyphylla is an oriental folk medicine that has anticancer activities both in vivo and in vitro. Polyphyllin VII (PP7), a pennogenyl saponin from P. polyphylla has been found to exert strong anticancer activity. However, the underlying mechanisms are poorly understood. In the present study... | These results demonstrated that PP7 induced apoptotic cell death in HepG2 cells through both intrinsic and extrinsic pathways by promoting the generation of mitochondrial-mediated ROS and activating MAPK and PTEN/p53 pathways. | yes |
26,853,280 | Does hyperinflammation in patients with chronic granulomatous disease lead to impairment of hematopoietic stem cell functions? | {
"contexts": [
"Defects in phagocytic nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) function cause chronic granulomatous disease (CGD), a primary immunodeficiency characterized by dysfunctional microbicidal activity and chronic inflammation.",
"We sought to study the effect of chronic inflamma... | Persistent chronic inflammation in patients with CGD is associated with hematopoietic proliferative stress, leading to a decrease in the functional activity of HSCs. Our observations have clinical implications for the development of successful autologous cell therapy approaches. | yes |
26,869,290 | Does sGK Kinase Activity in Multiple Myeloma Cells protect against ER Stress Apoptosis via a SEK-Dependent Mechanism? | {
"contexts": [
"To assess the role of the serum and glucocorticoid-regulated kinase (SGK) kinase in multiple myeloma, we ectopically expressed wild type or a phosphomimetic version of SGK into multiple myeloma cell lines. These cells were specifically resistant to the ER stress inducers tunicamycin, thapsigargin... | Enhanced SGK expression and activity in multiple myeloma cells contributes to resistance to ER stress, including bortezomib challenge. | yes |
26,864,953 | Does a Comparison of Intravascular Imaging Modalities for Detection of Stent strut in Acute Coronary Syndrome? | {
"contexts": [
"We used optical coherence tomography (OCT) and intravascular ultrasound (IVUS) to assess the struts of implanted stents in patients with acute coronary syndrome (ACS).",
"A totle of 10,756 stent struts were analyzed with OCT in 42 patients of ACS. Of them, both of IVUS and OCT imaging were pe... | Stent struts are frequently buried and nondetectable due to thrombi burden in ACS patients. Adequate thrombus removal and proper selection of the imaging device is warranted in ACS. | yes |
26,874,653 | Does recurrent recessive mutation in deoxyguanosine kinase cause idiopathic noncirrhotic portal hypertension? | {
"contexts": [
"Despite advances in the diagnosis and management of idiopathic noncirrhotic portal hypertension, its pathogenesis remains elusive. Insight may be gained from study of early-onset familial idiopathic noncirrhotic portal hypertension, in which Mendelian mutations may account for disease. We perform... | Our findings provide new insight into the mechanisms mediating inherited and acquired noncirrhotic portal hypertension, expand the phenotypic spectrum of DGUOK deficiency, and provide a new genetic test for a specific cause of idiopathic noncirrhotic portal hypertension. (Hepatology 2016;63:1977-1986). | yes |
26,857,862 | Does adipokine zinc-alpha-2-glycoprotein as a novel urinary biomarker present earlier than microalbuminuria in diabetic nephropathy? | {
"contexts": [
"To investigate the role of zinc-alpha-2-glycoprotein (ZAG) in the early stage of diabetic nephropathy, in patients with type 2 diabetes mellitus (T2DM).",
"This cross-sectional observational study recruited patients with longstanding T2DM and healthy control subjects. Patients with T2DM were ... | These preliminary findings suggest that ZAG might be a potentially useful biomarker for early diagnosis of diabetic nephropathy in patients with T2DM. | yes |
26,859,371 | Does frequent injection cocaine use increase the risk of renal impairment among hepatitis C and HIV coinfected patients? | {
"contexts": [
"To examine the association between injection cocaine use, hepatitis C virus (HCV) infection, and chronic renal impairment (CRI).",
"Prospective observational cohort study of HIV-HCV coinfected patients.",
"Data from 1129 participants in the Canadian Co-Infection Cohort with baseline and f... | After accounting for HCV RNA, frequent and cumulative injection cocaine abuse was associated with CRI progression and should be taken into consideration when evaluating impaired renal function in HIV-HCV coinfection. | yes |
26,871,998 | Is obstructive Sleep Apnea Associated with Higher Health Care Use after Colonoscopy under Conscious Sedation? | {
"contexts": [
"The use of sedation allows medical procedures to be performed outside the operating room while ensuring patient comfort and a controlled environment to increase the yield of the procedure. There is concern about a higher risk of adverse events with use of sedation in patients with obstructive sle... | The presence of obstructive sleep apnea was not associated with increased early hospital admissions, ICU admissions, or emergency room visits after colonoscopy with sedation. | no |
26,874,041 | Are postoperative plasma 8-iso-prostaglandin F2α levels associated with delirium and cognitive dysfunction in elderly patients after hip fracture surgery? | {
"contexts": [
"Oxidative stress may be involved in occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD). 8-iso-Prostaglandin F2α (8-iso-PGF2α), an isoprostane derived from arachidonic acid via lipid peroxidation, is considered a gold standard for measuring oxidative stress. The present st... | Postoperative plasma 8-iso-PGF2α levels may have the potential to predict POD and POCD in elder patients undergoing hip fracture surgery. | yes |
26,870,964 | Is irisin Associated with Urotensin II and Protein Energy Wasting in Hemodialysis Patients? | {
"contexts": [
"Irisin is a newly identified myokine which can promote energy expenditure. Urotensin II (UII) is identified as the most potent mammalian vasoconstrictor to date. Previous studies showed that UII can aggravate insulin resistance while irisin alleviate insulin resistance. Through this study, it is ... | Our results are the first to provide the clinical evidence of the association among irisin, UII, and protein energy wasting. Our results hint that UII and protein energy wasting might inhibit the release or synthesis of irisin from skeletal muscles in HD patients. | yes |
26,865,921 | Is vegetable intake associated with lower Frammingham risk scores in Korean men : Korea National Health and Nutrition Survey 2007-2009? | {
"contexts": [
"Observational studies suggest that an association between vegetable consumption and coronary heart disease (CHD). However, the results are inconsistent. This study aimed to investigate the daily intake of vegetables on a national level and its effect on the risk of CHD risk, as determined by the ... | The major results of this study indicate that higher vegetable intake may help prevent CHD in Korean men. | yes |
26,862,033 | Is a multi-drug resistant Salmonella Typhimurium ST213 human-invasive strain ( 33676 ) containing the bla CMY-2 gene on an IncF plasmid attenuated for virulence in BALB/c mice? | {
"contexts": [
"Classical strains of Salmonella enterica serovar Typhimurium (Typhimurium) predominantly cause a self-limiting diarrheal illness in humans and a systemic disease in mice. In this study, we report the characterization of a strain isolated from a blood-culture taken from a 15-year old woman sufferi... | Strain 33676 showed two main features that differentiate it from the originally described ST213 strains: 1) the bla CMY-2 gene was not carried on the IncA/C plasmid, but on a conjugative IncF plasmid, which may open a new route of dissemination for this ESC-resistance gene, and 2) it expresses the H2 FljB flagella, in ... | yes |
26,867,914 | Does percutaneous biliary drainage effectively lower serum bilirubin to permit chemotherapy treatment? | {
"contexts": [
"For digestive tract cancers, the bilirubin threshold for administration of systemic chemotherapy can be 5 or 2 mg/dL (85.5 or 34.2 μmol/L) depending upon the regimen. We examined the ability of percutaneous biliary drainage (PBD) in patients with malignant biliary obstruction to achieve these cli... | PBD of malignant obstruction achieves clinically relevant reduction in serum bilirubin in the majority of patients within 1-2 months, irrespective of the pre-drainage serum bilirubin, sufficient to allow administration of systemic chemotherapy. However, the decision to undergo this procedure for this indication alone m... | yes |
26,863,115 | Does sequestration of Vascular Endothelial Growth Factor ( VEGF ) induce Late Restrictive Lung Disease? | {
"contexts": [
"Neonatal respiratory distress syndrome is a restrictive lung disease characterized by surfactant deficiency. Decreased vascular endothelial growth factor (VEGF), which demonstrates important roles in angiogenesis and vasculogenesis, has been implicated in the pathogenesis of restrictive lung dise... | These data show that mesenchyme-specific inhibition of VEGF in neonatal mice results in late restrictive disease, making this transgenic mouse a novel model for future investigations on the consequences of neonatal RDS and potential interventions. | yes |
26,867,892 | Does audiovisual Biofeedback improve Cine-Magnetic Resonance Imaging Measured Lung Tumor Motion Consistency? | {
"contexts": [
"To assess the impact of an audiovisual (AV) biofeedback on intra- and interfraction tumor motion for lung cancer patients.",
"Lung tumor motion was investigated in 9 lung cancer patients who underwent a breathing training session with AV biofeedback before 2 3T magnetic resonance imaging (MRI... | These results demonstrated that AV biofeedback significantly improved intra- and interfraction lung tumor motion consistency for lung cancer patients. These results demonstrate that AV biofeedback can facilitate consistent tumor motion, which is advantageous toward achieving more accurate medical imaging and radiation ... | yes |
26,866,641 | Is a New Radiographic Classification System for Developmental Hip Dysplasia Reliable and Predictive of Successful Closed Reduction and Late Pelvic Osteotomy? | {
"contexts": [
"The Tonnis radiographic classification of developmental dysplasia of the hip (DDH) has been used as a prognostic indicator for patients with walking-age DDH. The International Hip Dysplasia Institute (IHDI) classification, a new radiographic classification system, has been proposed to be more rel... | The IHDI classification is subjectively more facile to use and has excellent interrelater agreement for classifying the radiographic severity of DDH. It is also reliable in predicting success of closed reduction and need for late pelvic osteotomy. | yes |
26,867,493 | Do the pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis? | {
"contexts": [
"Alcoholic liver disease (ALD) ranges from fatty liver to inflammation and cirrhosis. miRNA-155 is an important regulator of inflammation. In this study, we describe the in vivo role of miR-155 in ALD.",
"Wild-type (WT) (C57/BL6J) or miR-155 knockout (KO) and TLR4 KO mice received Lieber DeCar... | Collectively our results demonstrated the role of miR-155 in alcohol-induced steatohepatitis and fibrosis in vivo. | yes |
26,867,494 | Does novel pre-mRNA splicing of intronically integrated HBV generate oncogenic chimera in hepatocellular carcinoma? | {
"contexts": [
"Hepatitis B virus (HBV) integration is common in HBV-associated hepatocellular carcinoma (HCC) and may play an important pathogenic role through the production of chimeric HBV-human transcripts. We aimed to screen the transcriptome for HBV integrations in HCCs.",
"Transcriptome sequencing was... | A pre-mRNA splicing mechanism is involved in the formation of HBV-human chimeric proteins. This represents a novel and possibly common mechanism underlying the formation of HBV-human chimeric transcripts from intronically integrated HBV genome with functional impact. | yes |
26,872,316 | Does thirty-minutes ' exposure to smartphone call trigger neutrophil activation in vitro? | {
"contexts": [
"Despite accumulating evidence about the negative health effects of exposure to electromagnetic fields emitted by mobile phones, no information is available on the potential impact of radiofrequency (RF) waves on polymorphonuclear leukocytes biology.",
"Two sequential whole blood tubes were co... | The results of this study show that exposure to smartphone RF waves triggers activation of neutrophils in vitro, as mirrored by the significant variations observed in many activation parameters in Advia 2120. | yes |
26,850,031 | Does visual identification of coronary calcifications on attenuation correction CT improve diagnostic accuracy of SPECT/CT myocardial perfusion imaging? | {
"contexts": [
"Coronary artery calcium (CAC) is a powerful CAD risk marker when assessed by dedicated calcium scoring CT scan. We assessed diagnostic implications of CAC visible on attenuation correction CT scans (CTAC) from SPECT/CT myocardial perfusion imaging (MPI).",
"Visual presence or absence of CAC w... | Visual assessment of CAC on CTAC should be performed during SPECT/CT MPI because it affects diagnostic certainty and may improve risk stratification. | yes |
26,862,059 | Are cD10-positive myoepithelial cells usually prominent around in situ lobular neoplasia of the breast and much less prominent or absent in DCIS? | {
"contexts": [
"To study the relationship between the neoplastic cells of in situ lobular neoplasia (ILN) and ductal carcinoma in situ (DCIS) and the surrounding CD10-positive myoepithelial cells.",
"Twenty consecutive cases of ILN and 51 of DCIS were stained for CD10 using the immunoperoxidase technique. Th... | There is a distinct relationship between the type and grade of in situ neoplasia of the breast and the surrounding CD10-positive myoepithelial cells, suggesting the presence of a 'cross talk' between the two elements. | yes |
26,873,001 | Does imaging mass spectrometry detect dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia? | {
"contexts": [
"The initial steps in the cascade leading to cell death are still unknown because of the limitations of the existing methodology, strategy, and modalities used.",
"Imaging mass spectrometry (IMS) was used to measure dynamic molecular changes of phosphatidylcholine (PC) species in the rat hippo... | Histopathology and IMS can provide comprehensive and complementary information on cell death mechanisms in the hippocampal CA1 after global ischemia. IMS provided novel data on molecular changes in phospholipids immediately after TGI. Increased level of PC (diacyl-16:0/22:6) in the pyramidal cell layer of hippocampal C... | yes |
26,873,092 | Does foxo3 circular RNA promote cardiac senescence by modulating multiple factors associated with stress and senescence responses? | {
"contexts": [
"Circular RNAs are a subclass of non-coding RNAs detected within mammalian cells. This study was designed to test the roles of a circular RNA circ-Foxo3 in senescence using in vitro and in vivo approaches.",
"Using the approaches of molecular and cellular biology, we show that a circular RNA g... | We conclude that ID-1, E2F1, FAK, and HIF1α interact with circ-Foxo3 and are retained in the cytoplasm and could no longer exert their anti-senescent and anti-stress roles, resulting in increased cellular senescence. | yes |
26,852,910 | Does variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associate with allergic rhinitis in Chinese subjects? | {
"contexts": [
"Allergic rhinitis (AR) is a complex chronic inflammatory disease of the nasal mucosa, caused by an interaction between genetic and environmental factors. As evidence suggests that some genetic variants may increase susceptibility to both AR and asthma, the objective of this study was to identify ... | These results suggest that the PBX2 gene in the 6p21.3 asthma susceptibility locus may be associated with increased risk for both AR and asthma in Chinese subjects. | yes |
26,849,538 | Do body Composition Changes in Adult Females after Lifestyle Intervention Are Influenced by the NYD-SP18 Variant? | {
"contexts": [
"The study focuses on the analysis of the possible relationship between a common NYD-SP18 (rs6971091, G>A) gene polymorphism and weight loss after lifestyle intervention (combined dietary intake and physical activity) in overweight/obese females.",
"We genotyped 139 unrelated non-diabetic Czec... | Overweight/obese female carriers of the NYD-SP18 rs6971091 GG genotype exhibited a more beneficial response to the intensive lifestyle intervention than others. | yes |
26,874,301 | Is a history of preeclampsia associated with a risk for coronary artery calcification 3 decades later? | {
"contexts": [
"A history of preeclampsia is an independent risk factor for cardiac events and stroke. Changes in vasculature structure that contribute to these associations are not well understood.",
"The aim of this study was to quantify coronary artery calcification (CAC), a known risk factor for cardiac ... | In this first prospective cohort study with confirmation of preeclampsia by medical record review, a history of preeclampsia is associated with an increased risk of CAC >30 years after affected pregnancies, even after controlling individually for traditional risk factors. A history of preeclampsia should be considered ... | yes |
26,864,301 | Is combination of non-ablative fractional photothermolysis and 0.1 % tacrolimus ointment efficacious for treating idiopathic guttate hypomelanosis? | {
"contexts": [
"The efficacy of fractional photothermolysis and topical use of calcineurin inhibitors as treatments of idiopathic guttate hypomelanosis (IGH) have been reported. Data on combination treatments are lacking.",
"To evaluate the efficacy and safety of 1550-nm ytterbium/erbium fiber laser combined... | Fractional 1550-nm ytterbium/erbium fiber laser combined with topical 0.1% tacrolimus ointment was effective for IGH. | yes |
26,870,092 | Do beneficial effects of silver foam dressing on healing of wounds with ulcers and infection control of burn patients? | {
"contexts": [
"To assess the beneficial effects of silver foam dressing on the healing of wounds with ulcers and infection control of burn patients.",
"Eighty-four second-degree burn patients were selected and divided into a study group and a control group (n=42). After disinfection and cleaning, wound beds... | Silver foam dressing rapidly, easily and safely resisted wound bacteria, promoted wound healing and shortened recovery time, effectively relieving the pain of patients. | yes |
26,872,002 | Are in sickness and in health : classmates highly motivated to provide in-hospital support during childhood cancer therapy? | {
"contexts": [
"Extended hospitalization for school-aged cancer patients increases their risk of social marginalization. School-aged children mature through peer-interaction, but healthcare providers fail to incorporate this in rehabilitation efforts. The RESPECT study offers classmates to cancer patients to bec... | Classmates are highly motivated to support patients during serious illness, irrespective of pre-existing friendships. Ambassadors offer a novel in-hospital approach to promote rehabilitation in children with severe/chronic diseases. Results need validation in other settings. Copyright © 2016 John Wiley & Sons, Ltd. | yes |
26,857,906 | Does a Single Protein Kinase A or Calmodulin Kinase II Site Control the Cardiac Pacemaker Ca2+ Clock? | {
"contexts": [
"Fight or flight heart rate (HR) increases depend on protein kinase A (PKA)- and calmodulin kinase II (CaMKII)-mediated enhancement of Ca(2+) uptake and release from sarcoplasmic reticulum (SR) in sinoatrial nodal cells (SANC). However, the impact of specific PKA and CaMKII phosphorylation sites o... | SR Ca(2+) depletion reduces HR and SR Ca(2+) repletion restores physiological SANC rate responses, despite CaMKII inhibition. PKA and CaMKII do not affect HR by a unique target site governing SR Ca(2+) uptake or release. HR acceleration may require an SR Ca(2+) content threshold. | no |
26,867,788 | Do age and muscle strength mediate the age-related biomechanical plasticity of gait? | {
"contexts": [
"Old compared with young adults walk with reduced ankle and increased hip mechanical output. We examined the idea that age, leg strength, or both are related to the age-related changes in mechanical output during gait.",
"Healthy young (n = 32, age 21.5 years) and old adults (n = 32, age 76.8 ... | Age and leg strength both contribute to the age-related changes in mechanical output during gait. Exercise prescription, normally targeting the knee extensors, should also involve ankle and hip muscles. | yes |
26,875,613 | Are antimicrobial effects of commensal oral species regulated by environmental factors? | {
"contexts": [
"The objectives of this study are to identify oral commensal species which can inhibit the growth of the main periodontopathogens, to determine the antimicrobial substances involved in these inhibitory activities and to evaluate the influence of environmental factors on the magnitude of these inhi... | Bacterial antagonism is species specific and depending on experimental as well as environmental conditions. Blocking hydrogen peroxide production neutralizes the inhibitory effect. | yes |
26,866,434 | Do cHORIORETINAL BIOPSY FOR THE DIAGNOSIS OF ENDOGENOUS ENDOPHTHALMITIS DUE TO ESCHERICHIA COLI? | {
"contexts": [
"To describe the novel use of a chorioretinal biopsy technique to confirm the microbiological diagnosis of endogenous Escherichia coli (E. coli) endophthalmitis, when other investigations have been proven nondiagnostic.",
"Case report of an 82-year-old white man with endogenous endophthalmitis... | Endogenous E. coli endophthalmitis is a rare and aggressive condition usually seen in patients with insulin-dependent diabetes with concurrent urinary tract infection. This case demonstrates chorioretinal biopsy to be a viable and effective method of establishing a firm microbiological diagnosis in cases of culture-neg... | yes |
26,868,498 | Does graph theoretical analysis reveal the reorganization of the brain network pattern in primary open angle glaucoma patients? | {
"contexts": [
"Most previous glaucoma studies with resting-state fMRI have focused on the neuronal activity in the individual structure of the brain, yet ignored the functional communication of anatomically separated structures. The purpose of this study is to investigate the efficiency of the functional commun... | Although the efficiency of functional communication is preserved in the brain network of the glaucoma at the global level, the efficiency of functional communication is altered in some specialized regions of the glaucoma. | yes |
26,857,534 | Do breast cancer stem cells phenotype and plasma cell-predominant breast cancer independently indicate poor survival? | {
"contexts": [
"Cancer stem cell-tumor microenvironment ecosystem is proposed to drive tumor heterogeneity. Tumor-infiltrating lymphocytes (TILs) in breast cancer ecosystem were demonstrated to indicate better prognosis and benefit from chemotherapy. This study sought to detect the association between breast can... | The BCSCs phenotype and PPBC may be helpful stratified factors in future clinical trials. The underlying mechanism needs further research. | yes |
26,850,262 | Does proximal Roux-en-y Gastrojejunal Anastomosis with Pyloric Ring Resection improve Gastric Emptying After Pancreaticoduodenectomy? | {
"contexts": [
"Delayed gastric emptying (DGE) is a common complication of pancreaticoduodenectomy. We determined the efficiency of a new reconstruction technique, designed to preserve motilin-secreting cells and maximize the utility of their receptors, in reducing the incidence of DGE after pancreaticoduodenect... | Our new reconstruction technique reduces the occurrence of DGE after pancreaticoduodenectomy. | yes |
26,848,562 | Does atp13a2 Deficiency aggravate Astrocyte-Mediated Neuroinflammation via NLRP3 Inflammasome Activation? | {
"contexts": [
"Atp13a2 (Park9) gene encodes a transmembrane lysosomal P5-type ATPase (ATP13A2), and its missense or truncation mutations leads to lysosomal dysfunction and consequently results in neuronal death in the pathogenesis of Parkinson's disease (PD). Nevertheless, the roles of ATP13A2 in the biological... | Our results have revealed a novel role of ATP13A2 in modulating astrocyte-mediated neuroinflammation via NLRP3 inflammasome activation, thus bringing to light of a direct link between astrocyte lysosome and neuroinflammation in the pathological model of PD. | yes |
26,863,458 | Do the Military Health Care System May Have the Potential to Prevent Health Care Disparities? | {
"contexts": [
"The existence of health disparities in military populations has become an important topic of research. However, to our knowledge, this is the first study to examine health disparities, as related to access to care and health status, among active duty soldiers and their families. Specifically, the... | In a health equity system of care such as the military health care system, active duty soldiers and their family members did not experience disparities in access to care or in important health outcomes of patient satisfaction, physical health status, or mental health status. | yes |
26,864,156 | Does reduction in radiation doses from paediatric CT scan in Great Britain? | {
"contexts": [
"Although CT scans provide great medical benefits, concerns have been raised about the magnitude of possible associated cancer risk, particularly in children who are more sensitive to radiation than adults. Unnecessary high doses during CT examinations can also be delivered to children, if the sca... | We found that mAs for head and trunk CTs was approximately halved starting around 1990, and age-specific mAs was generally used for paediatric scans after this date. These changes will have substantially reduced the radiation exposure to children from CT scans in Great Britain. | yes |
26,861,538 | Does automation of a Nile red staining assay enable high throughput quantification of microalgal lipid production? | {
"contexts": [
"Within the context of microalgal lipid production for biofuels and bulk chemical applications, specialized higher throughput devices for small scale parallelized cultivation are expected to boost the time efficiency of phototrophic bioprocess development. However, the increasing number of possibl... | The newly established assay proved to be applicable for absolute quantification of algal lipids avoiding limitations of currently established protocols, namely biomass adjustment and limited throughput. Automation was shown to improve data reliability, as well as experimental throughput simultaneously minimizing the ne... | yes |
26,878,122 | Is the protective effect of epicatechin on experimental ulcerative colitis in mice mediated by increasing antioxidation and by the inhibition of NF-κB pathway? | {
"contexts": [
"Ulcerative colitis (UC) is a chronic inflammatory intestinal disease. It is necessary to find out new effective drugs for UC. In our study epicatechin extracted from grape seed by our institute for the first time could treat UC effectively. Then anti-UC mechanisms of epicatechin were elucidated i... | Epicatechin has inhibitory effect on DSS-induced acute UC. This effect is mainly due to its antioxidant effect and the inhibition of inflammatory molecules related to NF-κB pathway. | yes |
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