pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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26,873,695 | Do surgically modifiable factors measured by computer-navigation together with patient-specific factors predict knee society score after total knee arthroplasty? | {
"contexts": [
"The purpose was to investigate whether patient-specific factors (PSF) and surgically modifiable factors (SMF), measured by means of a computer-assisted navigation system, can predict the Knee Society Scores (KSS) after total knee arthroplasty (TKA).",
"Data from 99 patients collected during a... | Younger age, better preoperative KSS-F scores and lower BMI before surgery, a positive tibial component slope and small changes in femoral offset were predictors of better KSS-F scores at 4-years. | yes |
26,855,003 | Is fetal exposure to placental corticotropin-releasing hormone associated with child self-reported internalizing symptoms? | {
"contexts": [
"Fetal exposure to maternal prenatal stress hormones such as cortisol exerts influences on the developing nervous system that persist and include risk for internalizing symptoms later in life. Placental corticotropin-releasing hormone (pCRH) is a feto-placental stress signal that also shapes fetal... | Findings suggest that elevated exposures to the feto-placental stress signal pCRH exert programming effects on the developing fetal central nervous system, with lasting consequences for child mental health. | yes |
26,861,368 | Is modified Ideal Cardiovascular Health Status Associated with Lower Prevalence of Stroke in Rural Northeast China? | {
"contexts": [
"In 2010, the American Heart Association developed a new definition of ideal cardiovascular health (CVH) based on seven cardiovascular health metrics. This study aimed to investigate the relationship between modified ideal CVH metrics and the risk of stroke in the rural population of Northeast Chi... | This study revealed that people with a better CVH status had a lower prevalence of stroke and the susceptibility of stroke increased with the decreasing of the number of ideal CVH metrics. | yes |
26,878,847 | Is detection of pup odors by non-canonical adult vomeronasal neurons expressing an odorant receptor gene influenced by sex and parenting status? | {
"contexts": [
"Olfaction is a fundamental sense through which most animals perceive the external world. The olfactory system detects odors via specialized sensory organs such as the main olfactory epithelium and the vomeronasal organ. Sensory neurons in these organs use G-protein coupled receptors to detect che... | Our results describe, for the first time, a sensory neural population with a specific molecular identity involved in the detection of pup odors. Moreover, it is one of the first reports of a group of sensory neurons the activity of which is sexually dimorphic and depends on social status. Our data suggest that the Olfr... | yes |
26,876,913 | Is cognitive impairment in late-life bipolar disorder associated with Alzheimer 's disease pathological signature in the cerebrospinal fluid? | {
"contexts": [
"Cognitive impairment is a common feature of late-life bipolar disorder (BD). Yet, there is limited information on the biological mechanisms associated with this process. It is uncertain whether cognitively impaired patients with BD may present the Alzheimer's disease (AD) bio-signature in the cer... | Cognitively impaired patients with BD do not display the so-called AD bio-signature in the CSF. We therefore hypothesize that cognitive deterioration in BD is not associated with the classical pathophysiological mechanisms observed in AD, i.e., amyloid deposition and hyperphosphorylation of microtubule-associated tau p... | no |
26,876,910 | Does confirmatory factor analysis of the Infant Feeding style Questionnaire in Latino families? | {
"contexts": [
"Parent feeding practices affect risk of obesity in children. Latino children are at higher risk of obesity than the general population, yet valid measure of feeding practices, one of which is the Infant Feeding Styles Questionnaire (IFSQ), have not been formally validated in Spanish.",
"To va... | In a sample of Latino families, pressuring, restrictive, and responsive constructs performed well. The modified IFSQ in both English and Spanish-speaking Latino families may be used to assess parenting behaviors related to early obesity risk in this at-risk population. | yes |
26,876,914 | Does manganese protect against the effects of alcohol on hypothalamic puberty-related hormones? | {
"contexts": [
"Since manganese (Mn) is capable of stimulating the hypothalamic-pituitary unit and advancing female puberty, we assessed the possibility that this element might overcome some of the detrimental effects of prepubertal alcohol (ALC) exposure on the hypothalamic control of pituitary function.",
... | These results suggest that low level Mn supplementation acts to protect the hypothalamus from some of the detrimental effects of ALC on puberty-related hormones. | yes |
26,873,435 | Does increased Expression of Tripartite Motif ( TRIM ) 47 be a Negative Prognostic Predictor in Human Prostate Cancer? | {
"contexts": [
"Many prognostic biomarkers associated with androgen signaling have been proposed in PC. The role of tripartite motif (TRIM) proteins remains unclear in PC. We investigated TRIM protein 47 (TRIM47) expression levels in human prostate tissues.",
"We performed immunohistochemistry using original... | The results of the present study indicated differential TRIM47 expression levels in human prostate tissues compared to benign tissues. Because high levels of TRIM47 expression were found to be a strong prognostic factor in PC, TRIM47 may represent a novel therapeutic target. | yes |
26,848,992 | Does g protein-coupled receptor 30 regulate trophoblast invasion and its deficiency is associated with preeclampsia? | {
"contexts": [
"Preeclampsia is known to be associated with reduced circulating levels of estrogen. The effects of estrogen in preeclampsia are normally mediated by the classical estrogen receptors. Intriguingly, a novel estrogen receptor, G protein-coupled receptor 30 (GPR30), has been recently found to play an... | The present study suggests that GPR30 is a critical regulator of trophoblast cell invasion, and as such may be a potential therapeutic interventional target for preeclampsia and other pregnancy complications resulting from impaired trophoblast invasion. | yes |
26,879,018 | Does tongxinluo reverse the Hypoxia-suppressed Claudin-9 in Cardiac Microvascular Endothelial Cells? | {
"contexts": [
"Claudin-5, claudin-9, and claudin-11 are expressed in endothelial cells to constitute tight junctions, and their deficiency may lead to hyperpermeability, which is the initiating process and pathological basis of cardiovascular disease. Although tongxinluo (TXL) has satisfactory antianginal effec... | The results manifested that TXL reversed the hypoxia-suppressed claudin-9 by elevating H3K9ac in its gene promoter, playing protective roles in HCMECs. | yes |
26,862,121 | Does ataxia telangiectasia mutated in cardiac fibroblasts regulate doxorubicin-induced cardiotoxicity? | {
"contexts": [
"Doxorubicin (Dox) is a potent anticancer agent that is widely used in the treatment of a variety of cancers, but its usage is limited by cumulative dose-dependent cardiotoxicity mainly due to oxidative damage. Ataxia telangiectasia mutated (ATM) kinase is thought to play a role in mediating the a... | ATM-regulated effects within cardiac fibroblasts are pivotal in Dox-induced cardiotoxicity, and antagonism of ATM and its functions may have potential therapeutic implications. | yes |
26,865,377 | Do the effect of fluctuating maskers on speech understanding of high-performing cochlear implant users? | {
"contexts": [
"The present study evaluated whether the poorer baseline performance of cochlear implant (CI) users or the technical and/or physiological properties of CI stimulation are responsible for the absence of masking release.",
"This study measured speech reception thresholds (SRTs) in continuous and... | The detrimental effect of fluctuating maskers on SRTs in CI users shown by prior studies was confirmed by the current study. Concluding, the absence of masking release is mainly caused by the technical and/or physiological properties of CI stimulation, not just the poorer baseline performance of many CI users compared ... | yes |
26,860,421 | Does high urinary albumin/creatinine ratio at admission predict poor functional outcome in patients with acute ischemic stroke? | {
"contexts": [
"Albuminuria and a low estimated glomerular filtration rate (eGFR) are widely recognised indices of kidney dysfunction and have been linked to cardiovascular events, including stroke. We evaluated albuminuria, measured using the urinary albumin/creatinine ratio (UACR), and the eGFR in the acute ph... | A high UACR at admission may predict a poor outcome at discharge in patients with acute ischemic stroke. | yes |
26,849,887 | Does waste dump in local communities in developing countries and hidden danger to health? | {
"contexts": [
"The rapid industrialisation and urbanisation fuelled by a fast-growing population has led to the generation of a huge amount of waste in most communities in developing countries. The hidden disorders and health dangers in waste dumps are often ignored. The waste generated in local communities is ... | Industrialisation and urbanisation have brought about a change in the waste that is generated in contemporary communities in developing countries. Therefore, there is the need to embrace speciation and sound management of waste, probably including bioremediation. | yes |
26,871,996 | Is arsenic trioxide-based therapy suitable for patients with psoriasis-associated acute promyelocytic leukemia - A retrospective clinical study? | {
"contexts": [
"Many patients with psoriasis have developed acute promyelocytic leukemia (APL) whereas few reports on psoriasis-associated APL were found in the published literature. This study was aimed to study the etiology, clinical characteristics, and prognosis of psoriasis-associated APL and to map a suita... | Psoriasis patients are at high risk for APL. The increased risk is most likely associated with the genetic background and bimolane treatment. The ATO-based therapy is especially suitable for patients with psoriasis-associated APL. Our study also brings a new treatment option for psoriasis. | yes |
26,856,319 | Does fluid consumption and taste novelty determine transcription temporal dynamics in the gustatory cortex? | {
"contexts": [
"Novel taste memories, critical for animal survival, are consolidated to form long term memories which are dependent on translation regulation in the gustatory cortex (GC) hours following acquisition. However, the role of transcription regulation in the process is unknown.",
"Here, we report t... | We demonstrate that in taste learning, transcription programs were activated following the physiological responses (i.e., fluid consumption following a water restriction regime, reward, arousal of the animal, etc.) and the specific information about a given taste (i.e., taste novelty). Moreover, the cortical differenti... | yes |
26,865,705 | Is excellent outcome of minimal residual disease-defined low-risk patients sustained with more than 10 years follow-up : results of UK paediatric acute lymphoblastic leukaemia trials 1997-2003? | {
"contexts": [
"Minimal residual disease (MRD) is defined as the presence of sub-microscopic levels of leukaemia. Measurement of MRD from bone marrow at the end of induction chemotherapy (day 28) for childhood acute lymphoblastic leukaemia (ALL) can highlight a large group of patients (>40%) with an excellent (>... | The excellent outcome for childhood ALL in patients with MRD <0.01% after induction chemotherapy is sustained for more than 10 years from diagnosis. This supports the potential exploration of further reduction of therapy in this group, in an attempt to reduce treatment-related mortality and late effects. | yes |
26,850,174 | Does zinc have insulin-mimetic properties which enhance spinal fusion in a rat model? | {
"contexts": [
"Previous studies have found that insulin or insulin-like growth factor treatment can stimulate fracture healing in diabetic and normal animal models, and increase fusion rates in a rat spinal fusion model. Insulin-mimetic agents, such as zinc, have demonstrated antidiabetic effects in animal and ... | This study demonstrates the potential benefit of a locally applied insulin-mimetic agent, such as zinc, in a rat lumbar fusion model. Previous studies have demonstrated the benefits of local insulin application in the same model, and it appears that zinc has similar effects. | yes |
26,861,796 | Do drivers who self-estimate lower blood alcohol concentrations are riskier drivers after drinking? | {
"contexts": [
"Alcohol increases the tendency for risky driving in some individuals but not others. Little is known about the factors underlying this individual difference. Studies find that those who underestimate their blood alcohol concentration (BAC) following a dose of alcohol tend to be more impulsive and... | The tendency to estimate lower BACs could support a series of high-risk decisions, regardless of one's actual BAC. This could include the decision to drive after drinking. | yes |
26,848,940 | Does comparison of Maximum Intercuspal Contacts of Articulated Casts and Virtual cast Requiring Posterior Fixed Partial Dentures? | {
"contexts": [
"To evaluate the accuracy of the CEREC CAD/CAM system in reproducing the maximum intercuspal contacts of the casts, which include posterior teeth preparation for a fixed partial denture (FPD).",
"Ten pairs of gypsum casts were mounted in articulators in maximum intercuspal position (MIP) to se... | When there is no posterior antagonist contact following tooth preparation for an FPD, taking a full-arch digital impression and designing the restoration on full-arch virtual models can be advocated. | yes |
26,879,370 | Does systematic data-querying of large pediatric biorepository identify novel Ehlers-Danlos Syndrome variant? | {
"contexts": [
"Ehlers Danlos Syndrome is a rare form of inherited connective tissue disorder, which primarily affects skin, joints, muscle, and blood cells. The current study aimed at finding the mutation that causing EDS type VII C also known as \"Dermatosparaxis\" in this family.",
"Through systematic dat... | Our work is significant not only because it sheds new light on the pathophysiology of EDS for the affected family and the field at large, but also because it demonstrates the utility of unbiased large-scale clinical recruitment in deciphering the genetic etiology of rare mendelian diseases. With unbiased large-scale cl... | yes |
26,873,192 | Does artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably suppress Hepatocellular Carcinoma? | {
"contexts": [
"Aberrant signal transducer and activator of transcription 3 (STAT-3) molecular signaling elicit hepatocellular carcinoma (HCC) in humans. Therefore, targeting STAT-3 is considered as an attractive option towards suppression of HCC in humans.",
"Our objective is to identify a potential small m... | All the above observations substantiated by unified computational and in vitro experimental approaches suggested its potential role as a therapeutic anti-cancer agent against HCC. | yes |
26,872,128 | Does surgical Debridement be Superior to Sole Antibiotic Therapy in a Novel Murine Posttraumatic Osteomyelitis Model? | {
"contexts": [
"Bone infections after trauma, i.e. posttraumatic osteomyelitis, pose one of the biggest problems of orthopedic surgery. Even after sufficient clinical therapy including vast debridement of infected bone and antibiotic treatment, regeneration of postinfectious bone seems to be restricted. One expl... | Thus, the animal model presented herein provides a reliable and fascinating tool to study posttraumatic osteomyelitis for clinical therapies. | yes |
26,872,126 | Does macrophage CGI-58 attenuate Inflammatory Responsiveness via Promotion of PPARγ Signaling? | {
"contexts": [
"Comparative gene identification-58 (CGI-58), an adipose triglyceride lipase (ATGL) coactivator, strongly promotes ATGL-mediated triglyceride (TG) catabolism. Beyond its function in promoting lipolysis, other features of CGI-58 have been proposed. Here, we investigated the role of CGI-58 in the re... | These results demonstrate that macrophage CGI-58 enhances PPARγ signaling and thus suppresses inflammatory responsiveness and mitochondrial dysfunction. | yes |
26,869,690 | Are plasma and intracellular ribavirin concentrations significantly altered by abacavir in hepatitis C virus-infected patients? | {
"contexts": [
"The objective of this study was to evaluate the effects of abacavir on intracellular ribavirin triphosphate and plasma ribavirin trough concentrations.",
"Hepatitis C virus-infected subjects who had been cured or failed prior treatment were randomized to 8 weeks of ribavirin alone (N = 14; we... | Abacavir did not significantly alter ribavirin or ribavirin triphosphate concentrations. | no |
26,859,740 | Does correction of Midface Depression Using an Inverted m-shaped Expanded Polytetrafluoroethylene Implant improve Gingival Exposure? | {
"contexts": [
"Current approaches for the treatment of gingival exposure are often time- and cost-consuming and/or rather invasive. We previously observed a strong correlation between the presence of gingival excess and midfacial depression and here propose an easy 1-step correction technique as a new strategy ... | For cases involving midface depression, the present technique provides an effective and permanent treatment strategy to improve excessive gingival exposure. This single-step approach is a safe and technically easy therapeutic option which is associated with high patient acceptance. | yes |
26,859,239 | Does active opioid use attenuate the humoral responses to inactivated influenza vaccine? | {
"contexts": [
"Influenza vaccination is recommended for vulnerable individuals, including active drug users, to prevent influenza complications and decrease influenza spread. Recent studies suggest that opioids negatively regulate immune responses in experimental models, but the extent to which opioid use will ... | Our results suggest that opioid use do not significantly alter antibody responses to influenza vaccine supporting the vaccination effort in these populations. | no |
26,853,255 | Is higher cancer antigen 125 level associated with the presence of permanent atrial fibrillation in systolic heart failure patients? | {
"contexts": [
"Atrial fibrillation (AF) is a common arrhythmia in heart failure (HF). Recent studies have shown that serum cancer antigen-125 (CA-125) levels are elevated in HF, and high levels of CA-125 in HF patients with sinus rhythm have been shown to be associated with the development of new onset AF. Howe... | We have shown that the CA-125 levels can be used to predict AF in patients with systolic HF. | yes |
26,853,256 | Does renal sympathetic denervation improve rate control in patients with symptomatic persistent atrial fibrillation and hypertension? | {
"contexts": [
"The aim of this study was to investigate whether renal sympathetic denervation (RSD) improves ventricular heart rate (HR) control in patients with persistent atrial fibrillation (AF).",
"Twenty-one patients (aged 57.5 ± 10.2 years, 76.2% male) with persistent AF and hypertension underwent RSD... | RSD could improve ventricular HR control in patients with persistent AF. RSD slowed AV node conduction in baseline HR-dependent manner. RSD may become an alternative non-pharmaceutical tool for rate control in patients with persistent AF. | yes |
26,861,724 | Does microRNA-208a potentiate Angiotensin II-triggered Cardiac Myoblasts Apoptosis via Inhibiting Nemo-like Kinase ( NLK )? | {
"contexts": [
"MicroRNA-208a (miR-208a) exacerbated cardiomyocyte apoptosis via inhibiting nemo-like kinase (NLK). miR-208a is a crucial molecule in the regulation of heart diseases, however, the biological function and underlying mechanism of miR-208a in the progression of cardiomyocyte apoptosis is not clearl... | miR-208a can promote Ang II-induced cardiomyocyte apoptosis via negatively regulating NLK expression, and inhibition of miR-208a may provide a novel therapeutic target for cardiomyocyte apoptosis. | yes |
26,852,333 | Do exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice? | {
"contexts": [
"The crosstalk between skeletal muscle (SkM) and beta cells plays a role in diabetes aetiology. In this study, we have investigated whether SkM-released exosome-like vesicles (ELVs) can be taken up by pancreatic beta cells and can deliver functional cargoes.",
"Mice were fed for 16 weeks with ... | Our data suggest that muscle ELVs might have an endocrine effect and could participate in adaptations in beta cell mass during insulin resistance. | yes |
26,867,062 | Do sacrum and Coccyx Radiographs Have Limited Clinical Impact in the Emergency Department? | {
"contexts": [
"The purpose of this study was to determine the yield and clinical impact of sacrum and coccyx radiographs in the emergency department (ED).",
"Consecutive sacrum and coccyx radiographs obtained in the EDs of four hospitals over a 6-year period were categorized as positive for acute fracture o... | ED sacrum and coccyx radiographs showed a low positivity rate and had no quantifiable clinical impact. We recommend that sacrum and coccyx radiographs be eliminated from ED practice and patients treated conservatively on the basis of clinical parameters. | yes |
26,874,524 | Does perineal body stretch during labor predict perineal laceration , postpartum incontinence , or postpartum sexual function : a cohort study? | {
"contexts": [
"The perineum stretches naturally during obstetrical labor, but it is unknown whether this stretch has a negative impact on pelvic floor outcomes after a vaginal birth (VB). We aimed to evaluate whether perineal stretch was associated with postpartum pelvic floor dysfunction, and we hypothesized t... | PB stretch during labor is unrelated to perineal laceration, postpartum incontinence, sexual activity, or sexual function. | no |
26,856,667 | Is the relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation modified by donor smoking and reperfusion hyperoxia? | {
"contexts": [
"Donor smoking history and higher fraction of inspired oxygen (FIO2) at reperfusion are associated with primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidative injury biomarkers would be elevated in PGD, with higher levels associated with donor exposure to cigare... | Plasma levels of lipid peroxidation products are higher in patients with severe PGD, in recipients of lungs from donors with smoke exposure, and in recipients exposed to higher Fio2 at reperfusion. Oxidative injury is an important mechanism of PGD and may be magnified by donor exposure to cigarette smoke and hyperoxia ... | yes |
26,877,947 | Do diabetic conditions modulate the adenosine monophosphate-activated protein kinase of podocytes? | {
"contexts": [
"Adenosine monophosphate-activated protein kinases (AMPKs), as a sensor of cellular energy status, have been known to play an important role in the pathophysiology of diabetes and its complications. Because AMPKs are known to be expressed in podocytes, it is possible that podocyte AMPKs could be a... | We suggest that diabetic conditions induce the relocation and suppression of podocyte AMPKα, which would be a suggestive mechanism in diabetic podocyte injury. | yes |
26,869,031 | Are knee biomechanics during walking in recurrent lateral patellar dislocation normalized by 1 year after medial patellofemoral ligament reconstruction? | {
"contexts": [
"Gait kinematics and kinetics of the knee before and after medial patellofemoral ligament (MPFL) reconstruction in patients with recurrent lateral patellar dislocation (RPD) are unknown. The purpose of this study was to measure knee kinematics and kinetics during gait before and 1 year after anato... | Initially, RPD patients had lower knee extension moments during gait compared with controls, but by 1 year after MPFL reconstruction, knee kinematics and kinetics of gait in the RPD patients had returned to normal. These observations indicate that MPFL reconstruction may help to delay prospective knee OA as long as pos... | yes |
26,869,033 | Does computer-assisted navigation decrease the change in the tibial posterior slope angle after closed-wedge high tibial osteotomy? | {
"contexts": [
"The purpose of the present study was to compare the change in tibial posterior slope angle (PSA) between patients treated via computer-assisted and conventional closed-wedge high tibial osteotomy (CWHTO). It was hypothesized that a decrease in the PSA would be less in the computer-assisted group ... | Computer-assisted CWHTO using four guide pins could avoid inadvertent change in the PSA. The navigation can be used in anticipation of decreasing the risk of change in the PSA in CWHTO, especially in patients whose preoperative PSA is small. The special attention should be paid to locate the hinge axis acutely and to m... | yes |
26,870,121 | Does influence of mouth rinse on the surface hardness of dental resin nano-composite? | {
"contexts": [
"The aim of this research was to assess the effect of mouth rinses with and without alcohol on the hardness of dental nano-filled composite.",
"The micro-hardness of fifty circular disk shaped specimens of 7 mm x 2 mm were measured after 14 days. Specimens were immersed into alcohol containing... | Alcohol containing mouth rinsing solutions have more deleterious effect on hardness of nano composites as compared to alcohol-free mouth rinses. | yes |
26,868,273 | Does supplementation of transport and freezing media with anti-apoptotic drugs improve ovarian cortex survival? | {
"contexts": [
"Ovarian tissue preservation is proposed to patients at risk of premature ovarian failure, but this procedure still needs to be optimized. To limit injury during ovarian tissue cryopreservation, anti-apoptotic drugs were added to the transport and freezing media of ovarian cortex tissue.",
"Sh... | Our results showed that the addition of S1P or Z-VAD-FMK to the transport and freezing media prior to ovarian tissue cryopreservation improves primordial follicular quality and therefore improves global tissue survival. This should ultimately lead to improved fertility restoration after auto-transplantation. | yes |
26,852,132 | Is downregulation of histone H2A and H2B pathways associated with anthracycline sensitivity in breast cancer? | {
"contexts": [
"Drug resistance in breast cancer is the major obstacle to effective treatment with chemotherapy. While upregulation of multidrug resistance genes is an important component of drug resistance mechanisms in vitro, their clinical relevance remains to be determined. Therefore, identifying pathways th... | This study revealed a key pathway that contributes to anthracycline resistance and established model systems for investigating drug resistance in all four major breast cancer subtypes. As the histone modification can be targeted with small-molecule inhibitors, it represents a possible means of reversing clinical anthra... | yes |
26,852,139 | Is amifampridine phosphate ( Firdapse ( ® ) ) effective and safe in a phase 3 clinical trial in LEMS? | {
"contexts": [
"We evaluated the efficacy and safety of amifampridine phosphate (Firdapse(®)) for symptomatic treatment in Lambert-Eaton myasthenic syndrome (LEMS).",
"Phase 3, randomized, double-blind, study. Patients were treated initially with amifampridine phosphate for 7-91 days, followed by randomizati... | This study provides Class I evidence of efficacy of amifampridine phosphate as a symptomatic treatment for LEMS. | yes |
26,860,188 | Does cocaine-mediated induction of microglial activation involve the ER stress-TLR2 axis? | {
"contexts": [
"Neuroinflammation associated with advanced human immunodeficiency virus (HIV)-1 infection is often exacerbated by chronic cocaine abuse. Cocaine exposure has been demonstrated to mediate up-regulation of inflammatory mediators in in vitro cultures of microglia. The molecular mechanisms involved i... | xThe current study demonstrates that cocaine-mediated activation of microglia involves up-regulation of TLR2 through the ROS-ER stress-ATF4-TLR2 axis. Understanding the mechanism(s) involved in cocaine-mediated up-regulation of ROS-ER stress/TLR2 expression and microglial activation could have implications for the deve... | yes |
26,875,426 | Does sevoflurane and thiopental preconditioning attenuate the migration and activity of MMP-2 in U87MG glioma cells? | {
"contexts": [
"Tumor cell migration and diffuse infiltration into brain parenchyma are known causes of recurrence after treatment in glioblastoma (GBM), mediated in part by the interaction of glioma cells with the extracellular matrix, followed by degradation of matrix by tumor cell derived proteases, particula... | These results suggest that both sevoflurane and thiopental have inhibitory effect on the migration and MMP-2 activity in glioma cells. Thus, it is important that the choice of anesthetics to be used during glioma surgery takes into account their inhibitory properties against the tumor cells. | yes |
26,878,774 | Does soluble receptor for advanced glycation end-products protect against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system? | {
"contexts": [
"Apoptosis participated in the pathological process of myocardial ischemia/reperfusion (I/R) injury. Previous studies have reported that endogenous substance sRAGE protect against I/R injury through inhibiting myocardial apoptosis. But the mechanisms are currently unknown. Prior work has demonstra... | Our data suggest that the inhibition of sRAGE on I/R-induced apoptosis is associated with activation and expression of proteasome, including improved proteasome activity and elevated β1i and β5i expression mediated by STAT3 activation. We predict that sRAGE is a novel intervention to target UPS activation for preventin... | yes |
26,873,324 | Does gene expression identify heterogeneity of metastatic behavior among gastrointestinal stromal tumors? | {
"contexts": [
"Adjuvant imatinib is useful in patients with gastrointestinal stromal tumors (GIST) at high risk of recurrence. At present, the risk of recurrence is determined based on tumor size, mitotic rate, tumor site, and tumor rupture. Previous studies using various biochemical pathways identified gene ex... | Hierarchical clustering using these gene sets identified at least two subsets of GIST with distinct clinical behavior and risk of metastatic disease. The use of gene expression analysis along with other known prognostic factors may better predict the long-term outcome following surgery, and thus restrict the use of adj... | yes |
26,868,135 | Does sulodexide reduce the inflammatory reaction and senescence of endothelial cells in conditions involving chronic venous disease? | {
"contexts": [
"According to previous studies, sulodexide suppresses intravascular inflammation when used in patients with chronic venous disease (CVD). In the current study, we tested the effect of prolonged in vitro exposure of human venous endothelial cells to the serum from patients with CVD, examining the f... | Chronic in vitro exposure of HUVEC to medium supplemented with CVD patient serum induces an inflammatory phenotype. Sulodexide treatment significantly reduces that effect and slows HUVEC senescence in the milieu of CVD serum. | yes |
26,863,260 | Does inhibition of p21-Activated Kinase 1 by IPA-3 promote Locomotor Recovery After Spinal Cord Injury in Mice? | {
"contexts": [
"Ninety-six male adult CD-1 mice were randomly divided into sham, spinal cord injury (SCI) + vehicle, and SCI + IPA-3 groups. Expression of matrix metalloproteinase (MMP)-2 and MMP-9, production of tumor necrosis factors (TNF)-α and interleukin (IL)-1β, tissue edema, blood-spinal cord barrier pene... | Inhibition of PAK1 by IPA-3 promoted recovery of neurological function, possibly by downregulating the expression of MMP-2, MMP-9, TNF-α, and IL-1β. Our data suggest that PAK1 may be a potential therapeutic target in patients with SCI. | yes |
26,857,195 | Does sT2 predict Mortality and Length of Stay in a Critically Ill Noncardiac Intensive Care Unit Population? | {
"contexts": [
"The biomarker suppression of tumorigenicity 2 (ST2) is a well-established clinical biomarker of cardiac strain and is frequently elevated in a variety of cardiac conditions. Here, we sought to evaluate the prognostic value of ST2 in critically ill medical intensive care unit (MICU) patients witho... | ST2 is increased and predictive of prognosis in critically ill patients without primary cardiac disease, suggesting that critically ill patients may often have unrecognized cardiac injury. Clinical decision support algorithms incorporating ST2 and hsTnT results may be useful in patient risk stratification. | yes |
26,870,942 | Does lithium ameliorate LPS-Induced Astrocytes Activation Partly via Inhibition of Toll-Like Receptor 4 Expression? | {
"contexts": [
"Astrocytes are critical for the development of postoperative cognitive dysfunction (POCD). In addition, astrocytes express toll-like receptors 4 (TLR4) and build up responses to innate immune triggers by releasing pro-inflammatory molecules. The pathogenesis of neurological disorders often involv... | Lithium can inhibit LPS-induced TLR4 expression and astrocytes activation. These results indicate that lithium plays an important role in astrocytes activation and neuroinflammation-related diseases, which may open new avenues for neuroscience and biomedical research, and also offers new insight into the treatment of P... | yes |
26,877,211 | Is apolipoprotein E genotype associated with cognitive impairment in older adults with bipolar disorder? | {
"contexts": [
"Cognitive decline is part of the long-term outcome for many individuals with bipolar disorder (BD). The ε4 allele (APOE*4) of apolipoprotein E (APOE) is a well-established risk factor for dementia in Alzheimer's disease (AD). However, its contribution to the risk of cognitive deterioration in BD ... | APOE*4 is not associated with the diagnosis of BD and does not impact the occurrence of dementia in BD. Given the distinct clinical and biological features of cognitive impairment in BD, we hypothesized that dementia in BD is unrelated to AD pathological mechanisms. | no |
26,849,270 | Does benchmark dose Based on Abnormality of WBC or Micronucleus Frequency in Benzene-Exposed Chinese Workers? | {
"contexts": [
"The aim of the study was to calculate benchmark dose for chromosomal damage and reduced white blood cell (WBC) associated with exposure to benzene (BZ).",
"A group of 317 exposed workers and 102 controls were examined for WBC count and genotoxicity by micronucleus (MN) frequency. The cumulati... | Benchmark dose estimates indicated that BZ exposure at levels below the current occupational exposure standard can induce genotoxicity and hematotoxicity. | yes |
26,865,862 | Do chicken embryonic stem cells and primordial germ cells display different heterochromatic histone marks than their mammalian counterparts? | {
"contexts": [
"Chromatin epigenetics participate in control of gene expression during metazoan development. DNA methylation and post-translational modifications (PTMs) of histones have been extensively characterised in cell types present in, or derived from, mouse embryos. In embryonic stem cells (ESCs) derived... | Chicken ESCs and PGCs differ from their mammalian counterparts with respect to H3K27 methylation. High enrichment of H3K27me3 at PCH is specific to pluripotent cells in chicken. Our results demonstrate that the dynamics in chromatin constitution described during mouse development is not universal to all vertebrate spec... | yes |
26,866,626 | Does aging promote Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis? | {
"contexts": [
"To quantify functional age-related changes in the cartilage antioxidant network in order to discover novel mediators of cartilage oxidative stress and osteoarthritis (OA) pathophysiology.",
"We evaluated histopathologic changes of knee OA in 10-, 20-, and 30-month-old male F344BN rats and ana... | Our results show that SIRT-3 mediates age-related changes in cartilage redox regulation and protects against early-stage OA. These findings suggest that mitochondrial acetylation promotes OA and that restoration of SIRT-3 in aging cartilage may improve cartilage resistance to oxidative stress by rescuing acetylation-de... | yes |
26,878,859 | Does disruption of clathrin-dependent trafficking result in the failure of grass carp reovirus cellular entry? | {
"contexts": [
"Grass carp reovirus (GCRV) is responsible for viral hemorrhagic disease in cultured grass carp (Ctenopharyngon idellus). GCRV is a non-enveloped, double-stranded RNA virus in the genus Aquareovirus, of the family Reoviridae, which encodes seven structural proteins (VP1-VP7) and five nonstructural... | Our findings suggest that GCRV might enter CIK cells via clathrin-mediated endocytosis in a pH-dependent manner. Additionally, dynamin is critical for efficient viral entry. | yes |
26,870,998 | Does integrative microRNA and gene profiling data analysis reveal novel biomarkers and mechanisms for lung cancer? | {
"contexts": [
"Studies on the accuracy of microRNAs (miRNAs) in diagnosing non-small cell lung cancer (NSCLC) have still controversial. Therefore, we conduct to systematically identify miRNAs related to NSCLC, and their target genes expression changes using microarray data sets.",
"We screened out five miRN... | Our results demonstrate that integrating miRNAs and target genes are valuable for identifying promising biomarkers, and provided a new insight on underlying mechanism of NSCLC. Further, our well-designed validation studies surely warrant the investigation of the role of target genes related to these 14 miRNAs in the pr... | yes |
26,878,472 | Does cholecystokinin in plasma predict cardiovascular mortality in elderly females? | {
"contexts": [
"Cholecystokinin (CCK) and gastrin are related gastrointestinal hormones with documented cardiovascular effects of exogenous administration. It is unknown whether measurement of endogenous CCK or gastrin in plasma contains information regarding cardiovascular mortality.",
"Mortality risk was e... | CCK in plasma is an independent marker of cardiovascular mortality in elderly female patients. The study thus introduces measurement of plasma CCK in gender-specific cardiovascular risk assessment. | yes |
26,866,935 | Does immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury modulate Molecular Outcomes Associated With Early Synovitis? | {
"contexts": [
"To test whether intraarticular corticosteroid injection mitigates injury-induced synovitis and collagen degradation after anterior cruciate ligament transection (ACLT) and to characterize the synovial response using a functional genomics approach in a preclinical model of posttraumatic osteoarthr... | Early intraarticular immunosuppression mitigated injury-induced increases in collagen fragments, an outcome better predicted by specific marker expression than by histologic measures of synovitis. | yes |
26,866,471 | Do elevated Blood Lead Levels Are Associated with Reduced Risk of Malaria in Beninese Infants? | {
"contexts": [
"Elevated blood lead levels (BLL) and malaria carry an important burden of disease in West Africa. Both diseases might cause anemia and they might entail long-term consequences for the development and the health status of the child. Albeit the significant impact of malaria on lead levels described... | Our study shows for the first time that BLL are negatively associated with malarial risk considering other risk factors. Malaria is one of the main causes of morbidity and mortality in infants under 5 years worldwide, and lead poisoning is the 6th most important contributor to the global burden of diseases measured in ... | yes |
26,866,473 | Does selenoprotein T exert an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson 's Disease? | {
"contexts": [
"Oxidative stress is central to the pathogenesis of Parkinson's disease (PD), but the mechanisms involved in the control of this stress in dopaminergic cells are not fully understood. There is increasing evidence that selenoproteins play a central role in the control of redox homeostasis and cell ... | Our findings indicate that selenoproteins such as SelT play a crucial role in the protection of dopaminergic neurons against oxidative stress and cell death, providing insight into the molecular underpinnings of this stress in PD. | yes |
26,876,793 | Is prostate-specific antigen lowering effect of metabolic syndrome influenced by prostate volume? | {
"contexts": [
"To investigate the influence of metabolic syndrome on prostate-specific antigen levels by considering prostate volume and plasma volume.",
"We retrospectively analyzed 4111 men who underwent routine check-ups including prostate-specific antigen and transrectal ultrasonography. The definition ... | Prostate-specific antigen levels in patients with metabolic syndrome seem to be lower, and this finding might be affected by the prostate volume. | yes |
26,865,738 | Do therapeutic potential of Polyalthia cerasoides stem bark extracts against oxidative stress and nociception? | {
"contexts": [
"Polyalthia cerasoides is a medicinal plant known for its ethnopharmacological importance. Despite this, investigation related to its therapeutic benefit is still unexplored.",
"To evaluate the stem bark extracts of Polyalthia cerasoides for pharmacological activities relating to inflammation,... | The ethyl acetate fraction enriched with flavinoids and steroids from Polyalthia cerasoides stem bark has potent bioactivity to combat inflammation, ROS and pain. This needs further characterization for potential therapeutic applications. | yes |
26,864,855 | Is the Alpha-defensin Test for Periprosthetic Joint Infections Affected by Prior Antibiotic Administration? | {
"contexts": [
"Previous studies have demonstrated that the administration of antibiotics to patients before performing diagnostic testing for periprosthetic joint infection (PJI) can interfere with the accuracy of test results. Although a single-institution study has suggested that alpha-defensin maintains its ... | The alpha-defensin test maintains its concentration and sensitivity for PJI even in the setting of antibiotic administration. Furthermore, among patients with PJI on antibiotics, the alpha-defensin tests demonstrated a higher sensitivity in detecting PJI when compared with the ESR, CRP, fluid PMN%, and fluid culture. T... | no |
26,851,698 | Does intranasal oxytocin enhance neural processing of monetary reward and loss in post-traumatic stress disorder and traumatized controls? | {
"contexts": [
"Anhedonia is a significant clinical problem in post-traumatic stress disorder (PTSD). PTSD patients show reduced motivational approach behavior, which may underlie anhedonic symptoms. Oxytocin administration is known to increase reward sensitivity and approach behavior. We therefore investigated ... | Oxytocin administration increased reward pathway sensitivity during reward and loss anticipation in PTSD patients and trauma-exposed controls. Thus, oxytocin administration may increase motivation for goal-directed approach behavior in PTSD patients and controls, providing evidence for a neurobiological pathway through... | yes |
26,873,241 | Does early beta-cell dysfunction characterize males with type 2 diabetes of Yemenite origin? | {
"contexts": [
"The aim of the current study was to characterize β-cell function, insulin sensitivity and line of inheritance in patients with recent-onset type 2 diabetes of Yemenite and non-Yemenite Jewish origin.",
"A cohort study including 121 GAD negative diabetic patients, 59 of Yemenite and 62 of non-... | Males with recent-onset diabetes of Yemenite origin have a significant reduction of β-cell function and reduced ability to compensate for insulin resistance compared with diabetic males of non-Yemenite origin. Both males and females of Yemenite origin have a significantly higher maternal inheritance of diabetes. These ... | yes |
26,873,243 | Does systemic antibiotic therapy significantly improve outcome in a rat model of implant-associated osteomyelitis induced by Methicillin susceptible Staphylococcus aureus? | {
"contexts": [
"Treatment of implant-associated osteomyelitis regularly involves the use of systemic antibiotics in addition to surgical intervention. However, it remains unclear if perioperative systemic application of bactericide substances can improve overall outcome in models of severe intramedullary infecti... | Systemic perioperative and implant-associated application of antibiotics were both comparably effective to treat implant-associated infections whereas the combined antibiotic therapy further reduced systemic signs of infection time dependent. | no |
26,859,358 | Is lamina Cribrosa Depth Associated With the Cup-to-Disc Ratio in Eyes With Large Optic Disc Cupping and Cup-to-Disc Ratio Asymmetry? | {
"contexts": [
"To investigate the lamina cribrosa (LC) depth and its relationship with the cup-to-disc ratio (CDR) in the eyes with generalized increased optic disc cupping and CDR asymmetry.",
"Glaucoma suspect subjects with a CDR≥0.7, CDR asymmetry ≥0.2 in the absence of visual field (VF) loss, and normal... | The LC depth was greater in eyes with generalized increased cupping, as well as in eyes with a higher CDR than fellow eyes, and was significantly related to the CDR. These results suggest that the clinical appearance of cup enlargement or cupping has LC displacement components. | yes |
26,859,359 | Is the Conjunctiva in Normal Tension Glaucoma Patients Thinner Than in Primary Open-Angle Glaucoma Patients : A Comparative Histologic Study? | {
"contexts": [
"To compare histologically the thickness of conjunctival specimens of normal tension glaucoma (NTG) patients with primary open-angle glaucoma (POAG) patients.",
"In this prospective study, 54 patients scheduled for trabeculectomy were categorized into NTG and POAG based on their maximum untrea... | The conjunctiva in patients with NTG was thinner than in POAG patients. This finding is an additional feature in the pattern of thinner ocular structures in patients with NTG. | yes |
26,864,064 | Are inflammation markers associated with metabolic syndrome and ventricular arrhythmia in patients with coronary artery disease? | {
"contexts": [
"Inflammation plays a major role in the development and progression of atherosclerosis and coronary artery disease (CAD). Inflammation markers, including white blood cell (WBC) count, C-reactive protein (CRP) and interleukin-6 (IL-6), are widely used for cardiovascular risk prediction. The aim of ... | WBC, CRP and IL-6 are strongly associated with components of the metabolic syndrome. Their strong association with life-threatening ventricular arrhythmia emphasizes the proarrhythmic role of inflammation in the increased cardiovascular risk of CAD patients. | yes |
26,857,965 | Is cochlear implantation a therapeutic option for superficial siderosis patients with sensorineural hearing loss? | {
"contexts": [
"Superficial siderosis is a rare disease that results from chronic bleeding in the subarachnoid space. Haemosiderin deposits throughout the subpial layers of the brain and spinal cord lead to progressive sensorineural hearing loss, which is seen in 95 per cent of patients with superficial siderosi... | The remarkable improvement in Abbreviated Profile of Hearing Aid Benefit scores shown in this study indicates that cochlear implantation leads to a better quality of life in superficial siderosis patients. | yes |
26,851,970 | Does intravenous Thrombolysis facilitate Successful Recanalization with Stent-Retriever Mechanical Thrombectomy in Middle Cerebral Artery Occlusions? | {
"contexts": [
"Several factors influence the outcome after acute ischemic stroke secondary to proximal occlusions of cerebral vessels. Among others, noneligibility for intravenous thrombolysis (IVT) and incomplete revascularization have been identified as predictors of unfavorable outcome. The aim of this study... | IVT and thrombus length are predictive factors for a successful recanalization in MT for acute ischemic stroke with underlying MCA occlusion. | yes |
26,860,664 | Does cortical vessel sign on susceptibility weighted imaging reveal clinically relevant hypoperfusion in internal carotid artery stenosis? | {
"contexts": [
"Internal carotid artery (ICA) stenosis can lead to cerebral hypoperfusion and is a common cause of stroke. As susceptibility weighted imaging (SWI) has been used for penumbra imaging in acute ischemic stroke, we aimed at analyzing hypoperfusion using SWI in patients with ICA stenosis.",
"Clin... | In patients with ICA stenosis, asymmetric cortical vessel sign is a sign of clinically relevant hypoperfusion. | yes |
26,866,843 | Does stakeholder attitudes and need regarding cell-free fetal DNA testing? | {
"contexts": [
"To explore stakeholder views on cell-free DNA testing and highlight findings important for successful implementation and the provision of best practice in counseling.",
"Noninvasive tests based on the analysis of cell-free fetal DNA are now widely available in clinical practice and applicatio... | Stakeholders are positive about the introduction of cell-free fetal DNA testing into clinical practice. They describe both practical and psychological benefits arising from tests that are safe and can potentially be performed earlier in pregnancy. Key concerns, which include the potential for these tests to have a nega... | yes |
26,848,953 | Does hypothermia protect and Prolongs the Tolerance Time of Retinal Ganglion Cells against Ischemia? | {
"contexts": [
"Hypothermia has been shown to be neuroprotective in the therapy of ischemic stroke in the brain. To date no studies exist on the level of the inner retina and it is unclear if hypothermia would prolong the ischemic tolerance time of retinal ganglion cells, which are decisive in many ischemic reti... | Hypothermia protects retinal ganglion cells against ischemia and prolongs their ischemic tolerance time. | yes |
26,867,084 | Does duration of anuria predict recovery of renal function after acute kidney injury requiring continuous renal replacement therapy? | {
"contexts": [
"Little is known regarding the incidence rate of and factors associated with developing chronic kidney disease after continuous renal replacement therapy (CRRT) in acute kidney injury (AKI) patients. We investigated renal outcomes and the factors associated with incomplete renal recovery in AKI pa... | The renal outcome of severe AKI requiring CRRT was poor even in patients without further RRT. Long-term monitoring of renal function is needed, especially in severe AKI patients who are old and have a long duration of anuria. | yes |
26,876,682 | Does aLA-PDT elicit oxidative damage and apoptosis in UVB-induced premature senescence of human skin fibroblasts? | {
"contexts": [
"5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has been used for the treatment of skin photoaging. It can significantly improve the appearance of fine lines, dotted pigmentation, and roughness of photoaged skin. However, the mechanisms by which ALA-PDT yields rejuvenating effects on photoag... | Our study demonstrated that ALA-PDT elicits oxidative damage and apoptosis in photoaged fibroblasts in vitro, which may be the basis for the rejuvenating effects on photoaged skin. | yes |
26,865,420 | Does magnetic resonance imaging reveal the complementary effects of decongestant and Breathe Right Nasal Strips on internal nasal anatomy? | {
"contexts": [
"This magnetic resonance imaging (MRI) study of 26 subjects with nasal congestion was performed to assess in the complete nasal passage both the anatomical effect of the marketed Breathe Right Nasal Strip (BRNS) relative to placebo and the potential adjunctive effect of using a decongestant in com... | The BRNS alone significantly increases nasal patency and alleviates perceived nasal congestion, and additional relief of symptoms can be obtained with simultaneous use of a decongestant. | yes |
26,858,005 | Does chronic Alcohol Consumption cause Liver Injury in High-Fructose-Fed Male Mice Through Enhanced Hepatic Inflammatory Response? | {
"contexts": [
"Obesity and the metabolic syndrome occur in approximately one-third of patients with alcoholic liver disease (ALD). The increased consumption of fructose parallels the increased prevalence of obesity and the metabolic syndrome in the United States and worldwide. In this study, we investigated whe... | Our data suggest that dietary high fructose may potentiate chronic alcohol consumption-induced liver injury. The underlying mechanism might be due to the synergistic effect of dietary high fructose and alcohol on the activation of the TLR4 signaling pathway, which in turn leads to KC activation and phenotype switch tow... | yes |
26,876,448 | Is serum apolipoprotein E associated with long-term risk of Alzheimer 's disease : The Rotterdam Study? | {
"contexts": [
"Serum levels of apolipoprotein E (apoE) have been suggested as potential biomarker for dementia, but the long-term association between apoE and risk of dementia is uncertain.",
"Between 1990 and 1993, we measured serum apoE by immunoassay in 1042 non-demented individuals (mean ± SD age 68.4 ±... | Serum apoE is associated with long-term risk of Alzheimer's disease in the general population, independent of APOE genotype. Additional predictive value of serum apoE was limited. | yes |
26,857,816 | Does soluble adenylyl cyclase mediate hydrogen peroxide-induced changes in epithelial barrier function? | {
"contexts": [
"Elevated H2O2 levels are associated with inflammatory diseases and H2O2 exposure is known to disrupt epithelial barrier function, leading to increased permeability and decreased electrical resistance. In normal human bronchial epithelial (NHBE) cells, fully differentiated at the air liquid interf... | The data support an important role for prostaglandin activation of sAC and PKA in H2O2-induced barrier disruption. | yes |
26,860,125 | Is tachycardia burden in stroke unit associated with functional outcome after ischemic stroke? | {
"contexts": [
"Stroke unit care is associated with decrease in mortality and improvement in neurological outcome in patients with acute stroke. Heart rate is a commonly monitored variable in the stroke unit. However, little is known about tachycardia burden in the stroke unit and its association with outcome.",... | Patients with increased tachycardia burden during stroke unit stay have poor functional outcome. Countermeasures against worsening factors might be utilized for patients with increased tachycardia burden. | yes |
26,853,244 | Does cardiac Valve Noise Reduction by Non-Drug Interventions improve the Sleep Quality of Patients after Mechanical Cardiac Valve Implantation? | {
"contexts": [
"To investigate the effects of non-drug interventions on the sleep quality of patients after mechanical cardiac valve implantation.",
"In this prospective, randomized, controlled trial, 64 patients scheduled for mechanical mitral valve replacement were recruited. Patients underwent cognitive b... | Non-drug intervention could improve the sleep quality of patients after mechanical cardiac valve implantation and help the postoperative recovery of the patients. ( | yes |
26,868,311 | Does an Experiential Learning Model facilitate Learning of Bedside Ultrasound by Preclinical Medical Students? | {
"contexts": [
"To examine the effects of an experiential learning model of ultrasound training on preclinical medical students' knowledge and practice of Focused Assessment with Sonography for Trauma (FAST) examination.",
"The study was conducted in 2 phases. In phase 1, first- and second-year medical stude... | An experiential learning model of ultrasound training consisting of brief didactic presentation, practice FAST examinations on normal models, and proctored examinations on patients is an effective way to teach preclinical medical students basic ultrasound skills. | yes |
26,863,473 | Does oxygenated Hypothermic Machine Perfusion After Static Cold Storage improve Hepatobiliary Function of Extended Criteria Donor Livers? | {
"contexts": [
"The mechanism through which oxygenated hypothermic machine perfusion (HMP) improves viability of human extended criteria donor (ECD) livers is not well known. Aim of this study was to examine the benefits of oxygenated HMP after static cold storage (SCS).",
"Eighteen ECD livers that were decl... | Two hours of oxygenated HMP after traditional SCS restores hepatic ATP levels and improves hepatobiliary function but does not reduce (preexisting) hepatobiliary injury in ECD livers. | yes |
26,866,105 | Does mOLECULAR CHARACTERISATION AND ANTIMICROBIAL RESISTANCE PATTERNS OF ESCHERICHIA COLI isolate FROM GOATS SLAUGHTERED IN PARTS OF KENYA? | {
"contexts": [
"To determine the antibiotic resistance patterns of pathogenic Escherichia coli on goat meat carcass at Huruma and Kiserian abattoirs in Kenya.",
"Laboratory based study.",
"Huruma and Kiserian abattoirs in Kenya,",
"400 slaughtered goats inspected by veterinary health officers and app... | This study demonstrated that there is a significant level of antimicrobial resistance in pathogenic E. coli isolated from goat meat from Huruma and Kiserian abattoir. This indicates that goat meat from abattoirs could pose a risk of transmission of pathogenic antibiotic resistant strains to human. Poor hygienic standar... | yes |
26,855,320 | Is improvement of oral contraceptive-induced glucose dysregulation and dyslipidemia by valproic acid independent of circulating corticosterone? | {
"contexts": [
"Cardiometabolic disorders are rapidly becoming major public health challenges. Valproic acid (VPA) is a widely prescribed anticonvulsant drug.",
"We hypothesized that treatment with VPA would improve the regulation of glucose and atherogenic dyslipidemia through reduction in circulating corti... | The findings in this study suggest that VPA mitigates against the development of COC-induced insulin resistance and dyslipidemia independent of elevated circulating corticosterone. | yes |
26,850,746 | Do omega-3 fatty acids alter P-wave parameters in electrocardiogram or expression of atrial connexins in patients undergoing coronary artery bypass surgery? | {
"contexts": [
"We previously reported omega-3 polyunsaturated fatty acids (n-3PUFAs) supplementation does not reduce atrial fibrillation (AF) following coronary artery bypass graft (CABG) surgery. The aim of the present study is to evaluate the impact of n-3 PUFAs on electrocardiogram (ECG) atrial arrhythmic ma... | Omega-3 polyunsaturated fatty acids supplementation does not alter pro-arrhythmic P-wave parameters in ECG or connexin expression in human atrium with no effect on the incidence of AF following CABG surgery. | no |
26,852,287 | Is hPV status associated with altered PIWI-interacting RNA expression pattern in head and neck cancer? | {
"contexts": [
"As HPV-induced cases of oral malignancy increase, it is important to understand the molecular differences between HPV positive and negative head and neck squamous cell carcinoma (HNSCC). PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs aberrantly expressed in cancer. We analyze... | The expression of specific piRNAs is deregulated in HNSCC, and changes with both HPV status and type. Importantly, a five-piRNA signature is able to delineate a subset of HPV-positive HNSCC patients with poor outcome, highlighting the potential utility of piRNAs in patient management. | yes |
26,868,262 | Does pulsatilla saponin A induce differentiation in acute myeloid leukemia in vitro? | {
"contexts": [
"To identify whether Pulsatilla saponin A (PsA), an active molecule extracted from Pulsatilla chinensis regel, can induce acute myeloid leukemia (AML) cells differentiate.",
"PsA was isolated from P. chinensis, and its effects of differentiation induction on both AML cell lines and the primary... | PsA can modify the differentiation activity of AML cells, probably though the MEK/ERK signaling pathway. | yes |
26,854,420 | Are brief alcohol intervention trials conducted by higher prestige authors and published in higher impact factor journals cited more frequently? | {
"contexts": [
"To examine the relationships between study quality, author prestige, journal impact factors, and citation rates of trials and to examine whether journal impact factors mediated the relationships between study quality and author prestige on citation rates.",
"We used bibliometric data from 128... | We conclude that studies conducted by more established authors and reported in more prestigious journal outlets are more likely to be cited by other scholars, even after controlling for various proxies of study quality. | yes |
26,860,844 | Do postoperative Respiratory Exercises Reduce the Risk of Developing Pulmonary Complications in Patients Undergoing Lobectomy? | {
"contexts": [
"To evaluate the effects of an intensive postoperative physiotherapy program focused on respiratory exercises in patients undergoing lobectomy by open thoracotomy.",
"Quasi-experimental study.",
"Tertiary referral academic hospital.",
"208 patients undergoing lobectomy by open thoracot... | Implementing a postoperative intensive physiotherapy program focused on respiratory exercises reduces the risk of PPCs and resultant LOS on patients undergoing lobectomy. | yes |
26,869,289 | Does oncogenic Gene Fusion FGFR3-TACC3 be Regulated by Tyrosine Phosphorylation? | {
"contexts": [
"Fibroblast growth factor receptors (FGFR) are critical for cell proliferation and differentiation. Mutation and/or translocation of FGFRs lead to aberrant signaling that often results in developmental syndromes or cancer growth. As sequencing of human tumors becomes more frequent, so does the det... | These results demonstrate that FGFR3 kinase activity is essential for the oncogenic effects of the FGFR3-TACC3 fusion protein and could serve as a therapeutic target, but that phosphorylated tyrosine residues within the TACC3-derived portion are not critical for activity. Mol Cancer Res; 14(5); 458-69. ©2016 AACR. | yes |
26,874,643 | Does biodentine reduce Tumor Necrosis Factor Alpha-induced TRPA1 Expression in Odontoblastlike Cells? | {
"contexts": [
"The transient receptor potential (TRP) ion channels have emerged as important cellular sensors in both neuronal and non-neuronal cells, with TRPA1 playing a central role in nociception and neurogenic inflammation. The functionality of TRP channels has been shown to be modulated by inflammatory cy... | In conclusion, this study showed TRPA1 to be modulated by caries-induced inflammation and that Biodentine reduced TRPA1 expression and functional responses. | yes |
26,874,646 | Is locomotive syndrome associated not only with physical capacity but also degree of depression? | {
"contexts": [
"Reports of locomotive syndrome (LS) have recently been increasing. Although physical performance measures for LS have been well investigated to date, studies including psychiatric assessment are still scarce. Hence, the aim of this study was to investigate both physical and mental parameters in r... | The results indicate that LS is associated with not only the capacity of physical performance but also the degree of depression although most participants fell under the criteria of LS. | yes |
26,879,597 | Does a prehospital screening tool utilizing end-tidal carbon dioxide predict sepsis and severe sepsis? | {
"contexts": [
"To determine the utility of a prehospital sepsis screening protocol utilizing systemic inflammatory response syndrome (SIRS) criteria and end-tidal carbon dioxide (ETCO2).",
"We conducted a prospective cohort study among sepsis alerts activated by emergency medical services during a 12 month ... | A prehospital screening protocol utilizing SIRS criteria and ETCO2 predicts sepsis and severe sepsis, which could potentially decrease time to therapeutic intervention. | yes |
26,871,711 | Are body mass index curves for Italian preterm infants comparable with American curves for infants born before 34 weeks of gestational age? | {
"contexts": [
"Body mass index (BMI)-for-age curves have been developed in the USA, but not compared with other populations. This study created gender-specific intrauterine BMI-for-age curves for Italian preterm infants and compared them with the USA version.",
"Data on 92 262 newborn infants, born at 26-42... | We developed the first European BMI-for-age at birth curves for premature infants. According to our findings, the Italian curves were comparable to the USA curves for the subgroup of infants born at ≤33 gestational weeks, but not ≥34 gestational weeks. | yes |
26,857,637 | Does non-Fontan Adult Congenital Heart Disease Transplantation Survival be Equivalent to Acquired Heart Disease Transplantation Survival? | {
"contexts": [
"As a result of improved diagnostic methods, medical treatment, surgical correction, and palliation in childhood, there is a growing number of adult patients with congenital heart disease (CHD) who may experience heart failure and subsequently require heart transplantation (HT). Because of complex... | With careful donor and recipient selection, adults with end-stage CHD undergoing HT can achieve excellent early and midterm survival, comparable to the survival of patients who undergo transplantation for other diagnoses. | yes |
26,874,600 | Does transfusion of sex-mismatched and non-leukocyte-depleted red blood cells in cardiac surgery increase mortality? | {
"contexts": [
"To examine the mortality risk of blood transfusions when donor information, postdonation treatment, and a wide selection of risk factors are taken into account.",
"A retrospective study was performed on 9907 patients who underwent coronary artery bypass grafting and/or aortic valve replacemen... | In this large retrospective study, transfusion of non-sex-matched RBCs was associated with increased mortality. In addition, in patients receiving small amounts of blood, leukocyte depletion of RBCs had a beneficial effect on patient survival. | yes |
26,852,239 | Do fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice? | {
"contexts": [
"Fructus mume (F. mume) has been used as a traditional treatment for ulcer, cough, and digestive problems for many years in Asian countries. Previous studies have demonstrated that F. mume extracts alleviate cognitive deficits in rats with chronic cerebral hypoperfusion and in mice with scopolamin... | F. mume may have therapeutic effects on cognitive impairments in AD. | yes |
26,856,115 | Does high Proportion of Nuclear Phenotype identify Aggressive Cutaneous Squamous Cell Carcinoma? | {
"contexts": [
"To develop a quantitative histopathology algorithm to predict which patients with cutaneous squamous cell carcinoma (cSCC) were likely to experience recurrence or metastases.",
"This retrospective study of cSCC lesions compared patients with aggressive disease (n = 40) and those with nonaggre... | These data suggest that discriminant functions may be utilized to distinguish between aggressive and nonaggressive lesions at the time of diagnosis. | yes |
26,856,114 | Do serum Osteopontin Levels Correlate with Clinical and Pathological Features in Non-Small Cell Lung Cancer? | {
"contexts": [
"A metaanalysis was performed to investigate the association between serum osteopontin (OPN) levels and the clinical pathological features in non-small cell lung cancer (NSCLC) patients.",
"A systematic literature search was performed to identify relevant studies published prior to September 2... | Our findings revealed that serum OPN levels strongly correlate with clinical and pathological features in NSCLC patients. | yes |
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