pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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|---|---|---|---|---|
26,859,022 | Do cOAGULATION FACTORS LEVEL IN FRESH FROZEN PLASMA IN RWANDA? | {
"contexts": [
"Objectives: To determine the level of coagulation factors and inherited inhibitors in Fresh Frozen Plasma (FFP) and to evaluate Prothrombin Time and activated partial thrombin time in fresh frozen plasma.",
"Cross-sectional study.",
"Jomo Kenyatta University of Agriculture and Technology ... | There is good retention of all coagulation factors and inhibitors in plasma produced from whole blood within eight hours of collection, stored at minus 18 degrees C for three months. | yes |
26,866,381 | Does a Single-Nucleotide Polymorphism of miR-196a2T > C rs11614913 be Associated with Hepatocellular Carcinoma in the Chinese Population? | {
"contexts": [
"We investigated the miR-196a2T>C rs11614913 variant in the initiation and progression of hepatocellular carcinoma (HCC).",
"A case-control research model was conducted and the genotypes of 109 HCC patients and 105 healthy controls were identified by direct sequencing. The correlation between ... | In this study, we found that the CT+CC genotypes of rs11614913 were significantly associated with an increased risk and poor prognosis for HCC in the Chinese population. | yes |
26,870,105 | Do reconstruction of post burn scalp alopecia by using expanded hair-bearing scalp flaps? | {
"contexts": [
"Tissue expansion is a time-tested and frequently used procedure for utilizing local tissue to replace large defects. We aimed to assess the success & complications of tissue expansion in correction of post burn scalp alopecia.",
"In this study, 30 patients of scalp burn alopecia of 5 to 35 ye... | Tissue expansion is a simple, safe, & efficient technique for aesthetic scalp reconstruction. With a simple modification of distal incision and tunneling, we succeeded in minimizing complications. Versatile design of the expanded scalp flap can distribute the expanded hair-bearing scalp properly in the reconstructed re... | yes |
26,868,958 | Is down-Regulation of microRNA-132 Associated with Poor Prognosis of Colorectal Cancer? | {
"contexts": [
"Given the role of microRNA in colorectal cancer (CRC) progression, we explored the association between microRNA (miRNA) expression and CRC-related prognosis.",
"Three types of tissue samples (primary CRC lesions without liver metastasis, primary lesions with liver metastasis, and liver metast... | Down-regulation of miR-132 is associated with poor prognosis in CRC. ANO1 could be one of the crucial targets of miR-132 in CRC. | yes |
26,874,907 | Is neck circumference associated with carotid intimal-media thickness but not with coronary artery calcium : Results from The ELSA-Brasil? | {
"contexts": [
"It is uncertain whether neck circumference can be a risk indicator for subclinical atherosclerosis. We aimed to investigate their relationships measured by coronary artery calcium (CAC) and common carotid intima-media thickness (cc-IMT) with neck circumference in ELSA-Brasil.",
"In cross-sect... | Neck circumference was significantly and independently associated with cc-IMT but not with CAC in women and men, indicating a possible effect of perivascular fat tissue on atherosclerosis. | yes |
26,874,859 | Does select Bcl-2 antagonism restore chemotherapy sensitivity in high-risk neuroblastoma? | {
"contexts": [
"Pediatric patients with high-risk neuroblastoma (HR NB) often fail to respond to upfront intensive multimodal therapy. Tumor-acquired suppression of apoptosis contributes to therapy resistance. Many HR NB tumors depend on the anti-apoptotic protein Bcl-2 for survival, through Bcl-2 sequestration ... | HR NB patients are often thrombocytopenic at relapse, raising concerns for therapies like ABT-263 despite its HR NB tumor targeting potential. Our data confirms that Bcl-2 selective inhibitors like ABT-199 are equally potent in HR NB in vitro and in vivo and given their lack of platelet toxicity, should be translated i... | yes |
26,850,185 | Does polymyxin B hemoperfusion prevent acute kidney injury in sepsis model? | {
"contexts": [
"Direct hemoperfusion with a polymyxin B-immobilized column (PMX-DHP) adsorbs endotoxin and has been used for the treatment of septic shock. Yet, the mechanisms by which PMX-DHP acts on acute kidney injury are only partially understood.",
"Rats were anesthetized, tracheostomized, and placed on... | These findings suggest that PMX-DHP may protect against acute kidney injury not only by inhibiting the NF-κB signaling pathway but also by preventing renal tubular cell apoptosis. | yes |
26,850,186 | Does sildenafil obviate ischemia-reperfusion injury-induced acute kidney injury through peroxisome proliferator-activated receptor γ agonism in rats? | {
"contexts": [
"Sildenafil is a phosphodiesterase inhibitor used clinically for treating erectile dysfunction. Few studies suggest sildenafil to be a renoprotective agent. The present study investigated the involvement of peroxisome proliferator-activated receptor γ (PPAR-γ) in sildenafil-mediated protection aga... | It is concluded that sildenafil protects against ischemia-reperfusion-induced AKI through PPAR-γ agonism in rats. | yes |
26,850,187 | Does interleukin 6 production during cardiac surgery correlate with increasing age? | {
"contexts": [
"Cardiac surgery produces a proinflammatory response characterized by cytokine production. Proinflammatory cytokines such as interleukin 6 (IL-6) may contribute to morbidity and mortality after cardiopulmonary bypass (CPB). Elderly patients undergoing CPB are at increased risk of morbidity and mor... | These data suggest that patients aged >70 y undergoing cardiac operations generate more IL-6 during CPB. The increased circulating IL-6 in elderly patients may incite a proinflammatory state that could subsequently underlie the associated higher mortality and morbidity of these procedures in elderly patients. | yes |
26,850,182 | Does chromogranin A predict survival for resected pancreatic neuroendocrine tumors? | {
"contexts": [
"Currently, no serological prognostic marker exists for pancreatic neuroendocrine tumors (pNETs). Previous studies have suggested potential for chromogranin A (CgA); however, the prognostic capability of CgA remains controversial. Our purpose was to explore preoperative CgA levels in predicting ou... | In patients with resected pNETs, an elevated preoperative CgA level was negatively associated with DFS and OS and was the only independent predictor of DFS. These results indicate that preoperative CgA may be a clinically useful prognostic marker for patients undergoing pancreatic neuroendocrine tumor resection. | yes |
26,863,426 | Does c-Peptide be a Sensitive Indicator for the Diagnosis of Metabolic Syndrome in Subjects from Central Mexico? | {
"contexts": [
"Metabolic Syndrome (MetS) is associated with elevated risk for developing diabetes and cardiovascular disease. A key component of MetS is the development of insulin resistance (IR). The homeostatic model assessment (HOMA) model can determine IR by using insulin or C-peptide concentrations; howeve... | C-peptide is a strong indicator of MetS. Since C-peptide has recently emerged as a biomolecule with significant importance for inflammatory diseases, monitoring C-peptide levels will aid clinicians in preventing MetS. | yes |
26,854,749 | Is spontaneous bacterial peritonitis a risk factor for renal failure requiring dialysis in waitlisted liver transplant candidates? | {
"contexts": [
"To examine the relationship between and impact of spontaneous bacteria peritonitis (SBP) and renal failure requiring dialysis in waitlisted liver transplant (LT) candidates.",
"Renal failure is a common and severe complication in cirrhotic patients with SBP. Approximately one-third of patient... | Spontaneous bacteria peritonitis patients have a significantly increased likelihood to require dialysis and mean shorter waitlist time. Furthermore, the combined occurrence of SBP and dialysis is a strong risk factor for all-cause mortality while on the LT wait list. | yes |
26,879,207 | Is ovarian kisspeptin expression related to age and to monocyte chemoattractant protein-1? | {
"contexts": [
"The objective of this study was to test the hypothesis that ovarian kisspeptin (kiss1) and its receptor (kiss1r) expression are affected by age, obesity, and the age- and obesity-related chemokine monocyte chemoattractant protein-1 (MCP-1).",
"Ovaries from reproductive-aged and older C57BL/6J... | These data suggest a possible age-related physiologic role for the kisspeptinergic system in ovarian physiology. Additionally, the inflammatory MCP-1 may be associated with kiss1 and AMH genes, which are important in ovulation and folliculogenesis, respectively. | yes |
26,879,201 | Is lower leg muscle density independently associated with fall status in community-dwelling older adults? | {
"contexts": [
"Muscle density is a risk factor for fractures in older adults; however, its association with falls is not well described. After adjusting for biologically relevant confounding factors, a unit decrease in muscle density was associated with a 17 % increase in odds of reporting a fall, independent o... | Muscle density was associated with fall status, independent of functional mobility. Muscle density may compliment functional mobility tests as a biometric outcome for assessing fall risk in well-functioning older adults. | yes |
26,861,769 | Are guideline-concordant weight-loss programs in an urban area uncommon and difficult to identify through the internet? | {
"contexts": [
"To determine the reliability of Internet-based information on community-based weight-loss programs and grade their degree of concordance with 2013 American Heart Association, American College of Cardiology, and The Obesity Society weight-management guidelines.",
"An online search was conducte... | Most weight-loss programs in an urban, mid-Atlantic region do not currently offer guideline-concordant practices and fail to disclose key information online, which may make clinician referrals challenging. | yes |
26,878,055 | Are video capsule endoscopy completion and total transit times similar with oral or endoscopic delivery? | {
"contexts": [
"Video capsule endoscopy (VCE) is limited by incomplete procedures. There are also contraindications to the standard ingestion of the capsule that require endoscopic placement. Our aim was to compare the study completion rate of VCE after oral ingestion and endoscopic deployment.",
"We perform... | VCE completion rates and total transit times are similar after oral or endoscopic deployment for both hospitalized and ambulatory patients. Endoscopic placement is effective in patients with contraindications to standard oral ingestion, but should otherwise be avoided to limit unnecessary procedural risks and costs. | yes |
26,874,565 | Are sT-segment abnormalities associated with long-term prognosis in non-ST-segment elevation acute coronary syndromes : The ERICO-ECG study? | {
"contexts": [
"We aimed to identify whether ST-segment abnormalities, in the admission or during in-hospital stay, are associated with survival and/or new incident myocardial infarction (MI) in 623 non-ST-elevation acute coronary syndrome participants of the Strategy of Registry of Acute Coronary Syndrome (ERIC... | ST-segment abnormalities after the initial tracing added long-term prognostic information. | yes |
26,869,074 | Are β-catenin and Kras/Foxm1 signaling pathway critical to restrict Sox9 in basal cells during pulmonary branching morphogenesis? | {
"contexts": [
"Lung morphogenesis is regulated by interactions between the canonical Wnt/β-catenin and Kras/ERK/Foxm1 signaling pathways that establish proximal-peripheral patterning of lung tubules. How these interactions influence the development of respiratory epithelial progenitors to acquire airway as comp... | Interactions between the Wnt/β-catenin and the Kras/ERK/Foxm1 pathways are essential to restrict SOX9 expression in basal cells. Developmental Dynamics 245:590-604, 2016. © 2016 Wiley Periodicals, Inc. | yes |
26,869,077 | Do cervical cages placed bilaterally in the facet joints from a posterior approach significantly increase foraminal area? | {
"contexts": [
"Foraminal stenosis is a common cause of cervical radiculopathy. Posterior cervical cages can indirectly increase foraminal area and decompress the nerve root. The aim of this study was to assess the influence of bilateral posterior cervical cages on the surface area and shape of the neural forame... | Implantation of bilateral posterior cervical cages can increase foraminal area and may indirectly decompress the nerve roots. Correlation between increase in foraminal area and clinical outcomes needs further investigation. | yes |
26,853,184 | Does family need at a post-acute rehabilitation setting and suggestions for supports? | {
"contexts": [
"To explore the perceived needs, obstacles to services, psychological distress and social problem-solving abilities of family members of persons with ABI at a post-acute community-based brain injury rehabilitation facility and offer suggestions for methods of assessment and providing support.",
... | Family members who do not provide daily care are still impacted by the neurobehavioural changes that progress throughout the long-term, post-acute community phase. This study offers suggestions regarding an effective methodology for assessing family needs and recommends accessible and practical supports. | yes |
26,852,179 | Does progressive Coronary Dilatation predict Worse Outcome in Kawasaki Disease? | {
"contexts": [
"To explore the implication of serial coronary changes on the late coronary outcomes in patients with Kawasaki disease (KD) with coronary aneurysms ≧ 4 mm.",
"We performed a retrospective review of 78 patients with KD with large coronary aneurysms (1980-2013, male: 76.9%; 792 patient-years). P... | In addition to coronary diameters 1 month after the onset of KD, progressive coronary dilatation at 2 or more months after diagnosis may be an indicator of duration, and the severity of vasculitis and adverse dilative remodeling were associated with worse late coronary outcomes. | yes |
26,852,172 | Does underutilization of radiation therapy in early-stage marginal zone lymphoma negatively impact overall survival? | {
"contexts": [
"Multiple population-based studies have suggested increasing omission of radiation therapy in favor of alternative treatment strategies in lymphomas, with an associated negative impact on survival. Radiation therapy has long been considered the standard management for many mucosa-associated lympho... | Although clinical guidelines endorse radiation therapy as the preferred initial therapy for early-stage nongastric and Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma, radiation therapy is underused. Radiation therapy with or without systemic therapy was associated with a significant imp... | yes |
26,865,647 | Does l-Citrulline Supplementation enhance Fetal Growth and Protein Synthesis in Rats with Intrauterine Growth Restriction? | {
"contexts": [
"Intrauterine growth restriction (IUGR) results from either maternal undernutrition or impaired placental blood flow, exposing offspring to increased perinatal mortality and a higher risk of metabolic syndrome and cardiovascular disease during adulthood. l-Citrulline is a precursor of l-arginine a... | l-Citrulline increases fetal growth in a model of IUGR, and the effect may be mediated by enhanced fetal muscle protein synthesis and/or increased NO production. | yes |
26,865,645 | Does l-Glutamine enhance Tight Junction Integrity by Activating CaMK Kinase 2-AMP-Activated Protein Kinase Signaling in Intestinal Porcine Epithelial Cells? | {
"contexts": [
"The tight junctions (TJs) are essential for maintenance of the intestinal mucosal barrier integrity. Results of our recent work show that dietary l-glutamine (Gln) supplementation enhances the protein abundance of TJ proteins in the small intestine of piglets. However, the underlying mechanisms r... | Our findings indicate that activation of CaMKK2-AMPK signaling by Gln is associated with improved intestinal mucosal barrier function through enhancing the abundance of TJ proteins and altering their intracellular localization in intestinal porcine epithelial cells. | yes |
26,854,799 | Does low 25-Hydroxyvitamin D Level be Associated with Peripheral Arterial Disease in Type 2 Diabetes Patients? | {
"contexts": [
"Patients with type 2 diabetes have an increased risk of atherosclerosis and vascular disease. Vitamin D deficiency is associated with vascular disease and is prevalent in diabetes patients. We undertook this study to determine the association between 25-hydroxyvitamin D (25[OH]D) levels and preva... | Low serum 25(OH)D levels were significantly associated with a higher prevalence of PAD in type 2 diabetes patients <65 years of age. It may increase the risk of PAD independent of other known cardiovascular risk factors. | yes |
26,858,093 | Are interleukin-1β gene variants associated with QTc interval prolongation following cardiac surgery : a prospective observational study? | {
"contexts": [
"We characterized cardiac surgery-induced dynamic changes of the corrected QT (QTc) interval and tested the hypothesis that genetic factors are associated with perioperative QTc prolongation independent of clinical and procedural factors.",
"All study subjects were ascertained from a prospecti... | The results suggest a contribution of IL1β in modulating susceptibility to postoperative QTc prolongation after cardiac surgery. | yes |
26,867,118 | Do extracellular vesicles participate in the transport of cytokines and angiogenic factors in diabetic patients with ocular complications? | {
"contexts": [
"Extracellular vesicles (EVs), including circulating microvesicles (MVs) or mi- croparticles (MPs) and exosomes, derived from cells or platelets are present in the peripheral blood and are important elements involved in the activation of the coagulation system, transport of macromolecules and inte... | The profiles of cytokines and angiogenic factors in EVs are significantly increased in patients with diabetes. Also, the formation of specific cytokines related to EVs is strongly influenced by disease duration and successful treatment. EVs seem to be the conveyors of upregulated cytokines and angiogenic agents in diab... | yes |
26,875,547 | Does blockade of cell adhesion molecules enhance cell engraftment in a murine model of liver cell transplantation? | {
"contexts": [
"OLT is the best alternative for patients with end-stage liver diseases. However, as the need for organs surpasses donor availability, alternatives to OLT are required. LCT could be a useful option versus OLT in several patients even though its low cell-engraftment hampers its efficiency. Endothel... | Modification of the vascular wall with monoclonal antibodies against endothelial adhesion molecules before cell transplantation enhances cell engraftment into the mouse liver. | yes |
26,853,442 | Is p2X1-regulated IL-22 secretion by innate lymphoid cells required for efficient liver regeneration? | {
"contexts": [
"Paracrine signalling mediated by cytokine secretion is essential for liver regeneration after hepatic resection, yet the mechanisms of cellular crosstalk between immune and parenchymal cells are still elusive. Interleukin-22 (IL-22) is released by immune cells and mediates strong hepatoprotective... | This study shows that innate immune cell-derived IL-22 is required for efficient liver regeneration and that secretion of IL-22 in the regenerating liver is modulated by the ATP receptor, P2X1. (Hepatology 2016;63:2004-2017). | yes |
26,851,250 | Is very early social support following mild stroke associated with emotional and behavioral outcomes three months later? | {
"contexts": [
"To investigate whether social contact and support received during hospitalization for acute ischemic stroke predict depression and daily life functioning three months later.",
"Prospective observational study using Ecological Momentary Assessments to evaluate the number of social contacts as ... | Patient perceptions of better support quality, and not quantity, immediately following mild stroke, are associated with better behavioral and emotional outcomes three months later. | yes |
26,859,367 | Is timing of allergen exposure and the development of food allergy : treating before the horse out of the barn? | {
"contexts": [
"Until recently, nutritional guidelines did not support early introduction of allergenic foods into the diet of high-risk infants. Following recent studies, this approach is beginning to change, at least for peanuts. This review will examine the change in nutritional guidelines and the scientific ... | Recent studies suggest that early rather than late introduction of allergenic foods reduces the risk of food allergy. The preferred timing of food introduction might be sooner than the current recommendation, and might apply not only to high-risk infants. | yes |
26,875,265 | Do [ BONE TRANSPORTATION BY RING TYPE EXTERNAL FIXATOR COMBINED WITH LOCKED INTRAMEDULLARY NAIL FOR TIBIAL NON-INFECTIOUS DEFECT ]? | {
"contexts": [
"To explore the effectiveness of bone transportation by ring type extenal fixator combined with locked intramedullary nail for tibial non-infectious defect.",
"Between June 2008 and October 2012, 22 cases of tibial large segment defect were treated. There were 15 males and 7 females, aged 24-5... | Bone transportation by ring type external fixator combined with locked intramedullary nail could increase stability of extremities, allow early removal of external fixator and avoid axis shift of extremities, so it has good effect in treating tibial noninfectious defect. | yes |
26,851,944 | Do cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis? | {
"contexts": [
"Cancer-associated fibroblasts (CAFs) are believed to play an essential role in cancer initiation and development. However, little research has been undertaken to evaluate the role of CAFs in endometrial cancer (EC) progression. We aim to detect the functional contributions of CAFs to promote prog... | Our data indicated that CAFs derived from EC tissues promoted EC progression via the SDF-1/CXCR4 axis in a paracrine- or autocrine-dependent manner. SDF-1α is a novel independent poor prognostic factor for EC patients' survival. Targeting the SDF-1/CXCR4 axis might provide a novel therapeutic strategy for EC treatment. | yes |
26,868,285 | Is receipt of Care Discordant with Practice Guidelines Associated with Compromised Overall Survival in Nasopharyngeal Carcinoma? | {
"contexts": [
"It is unknown whether receiving treatment that is discordant with practice guidelines is associated with improved survival in patients with nasopharyngeal carcinoma. The objectives of this study were to characterise national treatment patterns, analyse whether treatment outside of practice guidel... | Many patients with stages I and IVC nasopharyngeal carcinoma do not receive care in accordance with practice guidelines. Receiving guidelines-discordant care is associated with compromised overall survival in the USA. | yes |
26,853,138 | Is carotid Intima-Media Thickness Associated with Markers of Atherosclerosis in Stroke Patients? | {
"contexts": [
"It has been argued that carotid intima-media thickness (IMT) could better reflect an adaptive response of the vessel wall rather than being a marker of atherosclerosis. We explore this hypothesis by analyzing the ARTICO data.",
"The ARTICO study was designed to evaluate the prognostic value o... | In our patients, carotid IMT does not seem to be associated with unequivocal markers of atheromatosis such as the existence of relevant carotid plaques or pathological ABI. These results as well as the association of IMT with age, hypertension, microalbuminuria, and mean waist perimeter support the hypothesis that IMT ... | no |
26,860,821 | Does a non-invasive magnetic resonance imaging-based model predict portal venous pressure? | {
"contexts": [
"To establish a non-invasive model for the assessment of portal venous pressure (PVP) based on the magnetic resonance (MR) parameters.",
"In this prospective study, contrast-enhanced magnetic resonance imaging (MRI) scan was performed in 109 patients indicated for upper abdominal surgeries aft... | The MRI-based formula has great potential for detecting portal hypertension. As a non-invasive measurement, it may be clinically accepted for the replacement of invasive modalities after further refinement. | yes |
26,857,210 | Does foxO3 inactivation promote human cholangiocarcinoma tumorigenesis and chemoresistance through Keap1-Nrf2 signaling? | {
"contexts": [
"FoxO transcription factors have been reported to play pivotal roles in tumorigenesis and drug resistance. The mechanisms underlying the tumor suppression function of FoxOs in human cancers remain largely unknown. Aberrant expression and activation of Nrf2 often correlate with chemoresistance and ... | Our results unravel a unique mechanism underlying the tumor suppressor function of FoxO3 through constraining Nrf2 signaling. (Hepatology 2016;63:1914-1927). | yes |
26,866,753 | Does head-Elevated Patient Positioning decrease Complications of Emergent Tracheal Intubation in the Ward and Intensive Care Unit? | {
"contexts": [
"Based on the data from elective surgical patients, positioning patients in a back-up head-elevated position for preoxygenation and tracheal intubation can improve patient safety. However, data specific to the emergent setting are lacking. We hypothesized that back-up head-elevated positioning wou... | Placing patients in a back-up head-elevated position, compared with supine position, during emergency tracheal intubation was associated with a reduced odds of airway-related complications. | yes |
26,850,822 | Does joint instability lead to long-term alterations to knee synovium and osteoarthritis in a rabbit model? | {
"contexts": [
"Joint instability is believed to promote early osteoarthritic changes in the knee. Inflammatory reactions are associated with cartilage degradation in osteoarthritis (OA) but their possible synergistic or additive effects remain largely unexplored. The goal of the present study was to investigate... | BTX-A induced joint instability in a muscle weakness model uniquely leads to alterations in gene expression and histological changes in the synovial membranes and cartilage in otherwise intact knee joints. These results lead to the conclusion that joint instability may promote an inflammatory intraarticular milieu, the... | yes |
26,855,586 | Are high levels of EGFR expression in tumor stroma associated with aggressive clinical features in epithelial ovarian cancer? | {
"contexts": [
"The aim of this study was to investigate the clinical significance and biological function of epidermal growth factor receptor (EGFR) expressed in tumor stroma of epithelial ovarian cancer.",
"Immunohistological staining of EGFR was evaluated in 242 patients with epithelial ovarian cancer. Th... | High expression of EGFR in tumor stroma correlates with aggressive clinical features in epithelial ovarian cancer, and is an independent prognostic factor. | yes |
26,853,811 | Is annual decline in forced expiratory volume steeper in aluminum potroom workers than in workers without exposure to potroom fumes? | {
"contexts": [
"Aluminum potroom exposure is associated with increased mortality of COPD but the association between potroom exposure and annual decline in lung function is unknown. We have measured lung volumes annually using spirometry from 1986 to 1996. The objective was to compare annual decline in forced ex... | Aluminum potroom operators have increased annual decline in FEV1 relative to a comparable group with non-exposure to potroom fumes and gases. | yes |
26,864,529 | Does a simple heated-capillary modification improve the analysis of non-covalent complexes by Z-spray electrospray ionization? | {
"contexts": [
"The observation of intact non-covalent complexes by electrospray ionization mass spectrometry (ESI-MS) hinges on the ability to minimize in-source activation processes that take place during analyte desolvation. We explored the merits of replacing the sampling cone of a standard Z-spray source wi... | The heated capillary minimizes in-source activation processes that can lead to unintended dissociation of complexes and perturbation of biomolecular structure, which rely on the integrity of non-covalent interactions. This effect can be attributed to the attenuation of the supersonic expansion typical of the Z-spray ge... | yes |
26,878,816 | Does initial varus displacement of proximal humerus fractures result in similar function but higher complication rates? | {
"contexts": [
"To investigate the effect of initial varus or valgus surgical neck alignment on outcomes of patients who sustained proximal humerus fractures treated with open reduction and internal fixation (ORIF).",
"An institutional review board approved database of proximal humerus fractures treated with... | In this study, initial surgical neck displacement in varus or valgus was found to not significantly affect functional outcome. Based upon our findings, patients with varus displaced proximal humerus fractures are at a greater risk of developing postoperative complications than those who present with initial valgus disp... | yes |
26,876,946 | Does a Human Open Field Test reveal Thigmotaxis Related to Agoraphobic Fear? | {
"contexts": [
"Thigmotaxis refers to a specific behavior of animals (i.e., to stay close to walls when exploring an open space). Such behavior can be assessed with the open field test (OFT), which is a well-established indicator of animal fear. The detection of similar open field behavior in humans may verify t... | This study is the first to our knowledge to verify the translational validity of the OFT and to reveal that thigmotaxis, an evolutionarily adaptive behavior shown by most species, is related to agoraphobia, a pathologic fear of open spaces, and anxiety sensitivity, a risk factor for agoraphobia. | yes |
26,851,722 | Does fetal thymus size in human pregnancies reveal inverse association with regulatory T cell frequencies in cord blood? | {
"contexts": [
"To determine fetal thymus growth and its relationship with fetal weight and cord blood T-regulatory cells in a prospective study. Assessment of fetal immune organs by ultrasound could provide a screening approach to identify fetuses at risk of impaired postnatal immunity.",
"Thymus size was m... | Fetal thymus growth is significantly correlated with fetal weight (GA 23-25 weeks r=0.40, p<0.01; GA 28-30 weeks r=0.21, p=0.04, GA 35-37 weeks r=0.56, p<0.01). We observed an inverse correlation between fetal thymus size at GA 23-25 weeks and cord blood Treg cells (r=0.37, p=0.01). Thymus growth occurs in a linear fas... | yes |
26,871,560 | Does distribution of Dengue Virus type 1 and 4 in Blood Components from Infected Blood Donors from Puerto Rico? | {
"contexts": [
"Dengue is a mosquito-borne viral disease caused by the four dengue viruses (DENV-1 to 4) that can also be transmitted by blood transfusion and organ transplantation. The distribution of DENV in the components of blood from infected donors is poorly understood.",
"We used an in-house TaqMan qR... | DENV was present in all tested components from most donors, and viral RNA was not preferentially distributed in any of the tested components. Infectious DENV was also present in similar proportions in cultured plasma, clot and CCWB samples, indicating that these components may serve as a resource when sample sizes are ... | yes |
26,869,829 | Does upregulation of heme oxygenase-1 by ginsenoside Ro attenuate lipopolysaccharide-induced inflammation in macrophage cells? | {
"contexts": [
"The beneficial effects of ginsenoside species have been well demonstrated in a number of studies. However, the function of ginsenoside Ro (GRo), an oleanane-type saponin, has not been sufficiently investigated. Thus, the aim of the present study was to investigate the anti-inflammatory effects of... | GRo induces anti-inflammatory effects following treatment with LPS via upregulation of HO-1. | yes |
26,863,007 | Do personality Traits of Suicidality Are Associated with Premenstrual Syndrome and Premenstrual Dysphoric Disorder in a Suicidal Women Sample? | {
"contexts": [
"Both Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD) might increase the risk of suicidal behavior. The aim of this study was to assess the relationship between personality dimensions specifically involved in suicidal vulnerability and PMS/PMDD.",
"We collected data from... | This study demonstrates a strong, independent association between PMS/PMDD and trait anger among a representative sample of female suicide attempters. It is of major interest for clinicians in view of addressing a substantial public health problem among women of reproductive age. | yes |
26,848,890 | Does genetic Variant in ACVR2B be Associated with Lean Mass? | {
"contexts": [
"Low lean mass (LM) is a risk factor for chronic disease, a major cause of disability and diminished quality of life, and is a heritable trait. However, relatively few specific genetic factors have been identified as potentially influencing this trait.",
"In this study, we selected 1493 single... | Our findings support a previously proposed role of ACVR2B allelic variation as a determinant of muscle mass and extend prior findings in men and women. Additional large-scale studies will be needed to confirm our findings in different populations. | yes |
26,873,329 | Does rhoA/Rho-kinase activation promote lung fibrosis in an animal model of systemic sclerosis? | {
"contexts": [
"Systemic sclerosis (SSc) is a connective-tissue disease characterized by vascular injury, immune-system disorders, and excessive fibrosis of the skin and multiple internal organs. Recent reports found that RhoA/Rho-kinase (ROCK) pathway is implicated in various fibrogenic diseases. Intradermal in... | Our findings confirm HOCl-induced pulmonary inflammation and fibrosis in mice, and provide further evidence for a key role of RhoA/ROCK pathway in several pathological processes of experimental SSc. Fasudil could be a promising therapeutic approach for the treatment of SSc. | yes |
26,859,806 | Do predictors of Human Papillomavirus Vaccination Among Young Men Who Have Sex With Men? | {
"contexts": [
"Human papillomavirus (HPV) is a common sexually transmitted infection that causes anal, penile, and oropharyngeal cancers in men. Men who have sex with men (MSM) are at particularly high risk for HPV infection and HPV-related disease. Human papillomavirus vaccination is currently recommended for ... | Findings highlight potential disparities in HPV vaccine uptake, as well as disparities in provider recommendation practices for HPV vaccination. Future interventions should aim to clarify misconceptions, modify psychosocial beliefs, and address barriers and facilitators to HPV vaccine uptake specific to young MSM. | yes |
26,860,700 | Is non-alcoholic Fatty Liver Disease ( NAFLD ) associated with impairment of Health Related Quality of Life ( HRQOL )? | {
"contexts": [
"NAFLD impacts patient reported outcomes (PROs). Our aim was to assess the impact of NAFLD on patients' HRQOL.",
"National Health and Nutrition Examination Survey (NHANES) 2001-2011 data were used to identify adult patients with NAFLD [Fatty Liver Index (FLI) > 60 in absence of other liver dis... | NAFLD causes impairment of HRQOL. As NAFLD is becoming the most important cause of CLD, its clinical and PRO impact must be assessed. | yes |
26,850,632 | Is the presence of fructosamine in human aortic valves associated with valve stiffness? | {
"contexts": [
"Human heart valves are prone to glycation, a fundamental process of ageing. The aim of this study was to establish the relationship between fructosamine formation and the mechanical properties of human aortic valves.",
"67 patients (age: 76±8 years) diagnosed with an aortic valve stenosis, wh... | Although no direct causativeness is proven with the presented results, which just show an association between fructosamine, the effect of FN3K and aortic valve stiffness, the present study points for the first time towards a possible additional role of the Amadori products in the biomechanical properties of ageing aort... | yes |
26,855,828 | Does fully automated open-source lesion mapping of T2-FLAIR images with FSL correlate with clinical disability in MS? | {
"contexts": [
"T2 Lesion Volume (T2LV) has been an important biomarker for multiple sclerosis (MS). Current methods available to quantify lesions from MR images generally require manual adjustments or multiple images with different contrasts. Further, implementations are often not easily or openly accessible.",... | Our T2LV quantification software produces T2LVs from a single FLAIR image that correlate with physical disability in MS and is freely available as open-source software. | yes |
26,879,230 | Does selective Targeting of a Novel Epsin-VEGFR2 Interaction promote VEGF-Mediated Angiogenesis? | {
"contexts": [
"We previously reported that vascular endothelial growth factor (VEGF)-induced binding of VEGF receptor 2 (VEGFR2) to epsins 1 and 2 triggers VEGFR2 degradation and attenuates VEGF signaling. The epsin ubiquitin interacting motif (UIM) was shown to be required for the interaction with VEGFR2. Howe... | Distinct residues in the epsin UIM and VEGFR2 mediate specific interactions between epsin and VEGFR2, in addition to UIM recognition of ubiquitin moieties on VEGFR2. These novel interactions are critical for pathophysiological angiogenesis, suggesting that these sites could be selectively targeted by therapeutics to mo... | yes |
26,870,315 | Does y-chromosome phylogeographic analysis of the Greek-Cypriot population reveal elements consistent with Neolithic and Bronze Age settlements? | {
"contexts": [
"The archeological record indicates that the permanent settlement of Cyprus began with pioneering agriculturalists circa 11,000 years before present, (ca. 11,000 y BP). Subsequent colonization events followed, some recognized regionally. Here, we assess the Y-chromosome structure of Cyprus in cont... | Analyses of Cypriot haplogroup data are consistent with two stages of prehistoric settlement. E-V13 and E-M34 are widespread, and PCA suggests sourcing them to the Balkans and Levant/Anatolia, respectively. The persistent pre-Greek component is represented by elements of G2-U5(xL30) haplogroups: U5*, PF3147, and L293. ... | yes |
26,850,378 | Is high Single-dose Vancomycin Loading Associated With Increased Nephrotoxicity in Emergency Department Sepsis Patients? | {
"contexts": [
"Vancomycin loading doses are recommended; however, the risk of nephrotoxicity with these doses is unknown. The primary objective of this study was to compare nephrotoxicity in emergency department (ED) sepsis patients who received vancomycin at high doses (>20 mg/kg) versus lower doses (≤20 mg/kg... | Initial dosing of vancomycin > 20 mg/kg was not associated with an increased rate of nephrotoxicity compared with lower doses. Findings from this study support compliance with initial weight-based vancomycin loading doses. | no |
26,849,730 | Does o-012 The Intestinal Wound Regeneration modulate Mucosal Microenvironment to Stimulate Expansion of a Local Pro-restitutive Microbiota? | {
"contexts": [
"Ulcerative colitis and Crohn's disease frequently cause epithelial damage in the intestine, leading to gut inflammation accompanied by areas of ulceration. The regeneration of damaged mucosa as well as the restoration of intestinal homeostasis involve induced and coordinated proliferation and mig... | These findings highlight a novel role of FPR1 to promote changes in the wound microenvironment to such extent that enriches a specific mucosa-associated bacterium to enhance enterocyte migration and proliferation in an FPR1-mediated and redox-dependent fashion. | yes |
26,870,821 | Does genetic Variation in NFKBIE be Associated With Increased Risk of Pneumococcal Meningitis in Children? | {
"contexts": [
"Streptococcus pneumoniae and Neisseria meningitidis are frequent pathogens in life-threatening infections. Genetic variation in the immune system may predispose to these infections. Nuclear factor-κB is a key component of the TLR-pathway, controlled by inhibitors, encoded by the genes NFKBIA, NFK... | A NFKBIE polymorphism was associated with increased risk of pneumococcal meningitis. | yes |
26,865,512 | Does urinary LRRK2 phosphorylation predict parkinsonian phenotypes in G2019S LRRK2 carriers? | {
"contexts": [
"To test whether phosphorylated Ser-1292 LRRK2 levels in urine exosomes predicts LRRK2 mutation carriers (LRRK2+) and noncarriers (LRRK2-) with Parkinson disease (PD+) and without Parkinson disease (PD-).",
"LRRK2 protein was purified from urinary exosomes collected from participants in 2 inde... | Elevated ratio of phosphorylated Ser-1292 LRRK2 to total LRRK2 in urine exosomes predicted LRRK2 mutation status and PD risk among LRRK2 mutation carriers. Future studies may explore whether interventions that reduce this ratio may also reduce PD risk. | yes |
26,865,516 | Does standardized EEG interpretation accurately predict prognosis after cardiac arrest? | {
"contexts": [
"To identify reliable predictors of outcome in comatose patients after cardiac arrest using a single routine EEG and standardized interpretation according to the terminology proposed by the American Clinical Neurophysiology Society.",
"In this cohort study, 4 EEG specialists, blinded to outcom... | Highly malignant EEG after rewarming reliably predicted poor outcome in half of patients without false predictions. An isolated finding of a single malignant feature did not predict poor outcome whereas a benign EEG was highly predictive of a good outcome. | yes |
26,869,797 | Is oct-4 associated with gastric cancer progression and prognosis? | {
"contexts": [
"To investigate the clinical significance of Oct-4 in the development and progression of gastric cancer.",
"Immunohistochemistry was used to analyze Oct-4 expression in 412 gastric cancer cases. Oct-4 protein levels were upregulated in gastric cancer tissues compared with adjacent noncancerous... | Oct-4 protein is a useful marker in predicting tumor progression and prognosis. | yes |
26,877,206 | Does effectiveness of hand hygiene depend on the patient 's health condition and care environment? | {
"contexts": [
"The present authors examined how patient hand contamination was associated with underlying disease and treatment environment in order to determine effective hand hygiene methods.",
"Samples were collected from inpatients (45 with hematological malignancies, 48 postoperative), outpatients (48 ... | Patient hand contamination is affected by underlying disease and care environment, but can be reduced by encouraging proper hand washing. Proper patient hand hygiene can reduce MRSA on patients' hands, and thus may serve as an effective tool for prevention of healthcare-associated infections. | yes |
26,876,574 | Does p38/JNK signaling pathway mediate the fluoride-induced down-regulation of Fam83h? | {
"contexts": [
"The similar clinical and pathological feature in fluorosis and amelogenesis imperfect with FAM83H mutations imply that excess fluoride could have effects on the expression of FAM83H and could elaborate this process by some signal pathways regulation. The present study aims to investigate the effe... | The findings suggest that JNK and P38 could be key regulatory element for Fam83h expression, and that LS8 cells can respond to fluoride by down-regulating Fam83h expression through the regulation of JNK and p38 signaling pathways. | yes |
26,874,894 | Does lung density associate with survival in alpha 1 antitrypsin deficient patients? | {
"contexts": [
"CT density correlates with quality of life (QOL) scores and impaired upper zone lung density associates with higher mortality in alpha one antitrypsin deficiency (A1ATD). We hypothesised that decline in CT densitometry would relate to survival or deterioration in QOL in A1ATD.",
"All augmenta... | Rate of change in lung densitometry could predict survival in A1ATD. | yes |
26,854,780 | Do a Comparison of the Effect Between Coronoid Process Graft and Costochondral Graft in the Reconstruction of Temporomandibular Joint? | {
"contexts": [
"Bone graft to reconstruct the temporomandibular joint for ankylosis patient is effective. This study used three-dimensional measurement to evaluate the effect between free coronoid process graft (CPG) and costochondral graft (CCG) in the temporomandibular joint reconstruction.",
"Patients tre... | CPG has higher frequency of a malocclusion secondary to resorption than CCG for the ramus reconstruction. | yes |
26,860,969 | Does transthoracic Echocardiography provide Important Long-Term Prognostic Information in Selected Patients Undergoing Endovascular Abdominal Aortic Repair? | {
"contexts": [
"The value of performing transthoracic echocardiography (TTE) as part of the clinical assessment of patients awaiting endovascular repair of the abdominal aorta is little evaluated. We aimed to estimate the prognostic importance of information derived from TTE on long-term all-cause mortality in a... | Echocardiography provides important long-term prognostic information in patients undergoing endovascular aneurysm repair. These TTE indices were more important at predicting outcome than standard conventional risk factors in this patient group. A greater tubular ascending aorta, presence of mitral regurgitation, reduce... | yes |
26,875,556 | Does follicular thyroid carcinoma but not adenoma recruit tumor-associated macrophages by releasing CCL15? | {
"contexts": [
"The differential diagnosis of follicular thyroid carcinoma (FTC) and follicular adenoma (FA) before surgery is a clinical challenge. Many efforts have been made but most focusing on tumor cells, while the roles of tumor associated macrophages (TAMs) remained unclear in FTC. Here we analyzed the d... | Our study suggested FTC might induce TAMs infiltration by producing CCL15. Measurement of TAMs and CCL15 in follicular thyroid lesions may be applied clinically to differentiate FTC from FA pre-operation. | yes |
26,850,597 | Are males seropositive for hepatitis B surface antigen at risk of lower bone mineral density : the 2008-2010 Korea National Health and Nutrition Examination Surveys? | {
"contexts": [
"Hepatic osteodystrophy has been reported in patients with various chronic liver diseases, including liver cirrhosis. However, it has not been well investigated in patients with hepatitis B virus infection. The aim of this study was to investigate the association between hepatitis B surface antige... | HBsAg seropositivity was significantly associated with lower BMD in male. Future long-term prospective studies investigating bone turnover markers and hormones are needed to better understand the pathophysiology and clinical significance of chronic hepatitis B virus-related hepatic osteodystrophy. | yes |
26,866,176 | Does mOLECULAR CHARACTERISATION AND ANTIMICROBIAL RESISTANCE PATTERNS OF ESCHERICHIA COLI isolate FROM GOATS SLAUGHTERED IN PARTS OF KENYA? | {
"contexts": [
"To determine the antibiotic resistance patterns of pathogenic Escherichia coli on goat meat carcass at Huruma and Kiserian abattoirs in Kenya.",
"Laboratory based study.",
"Huruma and Kiserian abattoirs in Kenya,",
"400 slaughtered goats inspected by veterinary health officers and app... | This study demonstrated that there is a significant level of antimicrobial resistance in pathogenic E. coli isolated from goat meat from Huruma and Kiserian abattoir. This indicates that goat meat from abattoirs could pose a risk of transmission of pathogenic antibiotic resistant strains to human. Poor hygienic standar... | yes |
26,859,090 | Does antroduodenal Manometry be Abnormal in Children Presenting With Orthostatic Intolerance and Gastrointestinal Symptoms? | {
"contexts": [
"Gastrointestinal (GI) symptoms of nausea, vomiting, and abdominal pain are common in patients with orthostatic intolerance (OI), including neurally mediated hypotension (NMH) and postural orthostatic tachycardia syndrome (POTS). Autonomic dysregulation is considered the underlying pathophysiology... | ADM is frequently abnormal in children with OI and GI symptoms. Upper GI motility studies should be a part of the comprehensive evaluation in this population. | yes |
26,855,396 | Is higher Mortality in Surgically Managed Diverticulitis Associated with Asian Ethnicity and Right-Sided Disease? | {
"contexts": [
"Although right-sided diverticulitis is perceived to have a higher incidence among Asians and infrequently requires surgical management in comparison with sigmoid diverticulitis, it is unknown whether differences in outcomes are due to ethnic disparity or disease pathophysiology.",
"The aim of... | The ethnicity variable was not uniformly collected by all states within the Nationwide Inpatient Sample database. | yes |
26,854,010 | Does molecular characterization of HCV in a Swedish county over 8 years ( 2002-2009 ) reveal distinct transmission patterns? | {
"contexts": [
"Hepatitis C virus (HCV) is a major public health concern and data on its molecular epidemiology in Sweden is scarce. We carried out an 8-year population-based study of newly diagnosed HCV cases in one of Sweden's centrally situated counties, Södermanland (D-county). The aim was to characterize th... | We found different transmission patterns in D-county which may, from a public health perspective, have implications for how to control virus infections by targeted interventions. | yes |
26,851,957 | Does uCA1 overexpression predict clinical outcome of patients with ovarian cancer receiving adjuvant chemotherapy? | {
"contexts": [
"Urothelial carcinoma associated 1 (UCA1) functions as an oncogene, which promotes cancer cell proliferation, invasion, and metastasis, and is responsible for drug resistance. This study aimed to determine the expression level of UCA1 in ovarian cancer and to further investigate its clinical signi... | Our findings provided the first evidence that UCA1 may serve as an indicator of response to chemotherapy and prognosis of ovarian cancer. UCA1 may play an important role in the progression of ovarian cancer. | yes |
26,872,828 | Do immediate effect of vibratory stimuli on quadriceps function in healthy adults? | {
"contexts": [
"The purpose of this study was to compare the effect of whole body vibration (WBV) and local muscle vibration (LMV) on quadriceps function.",
"Sixty adults were randomized to WBV, LMV, or control groups. Quadriceps function [Hoffmann (H)-reflex, active motor threshold (AMT), motor evoked poten... | WBV and LMV increased quadriceps function and may be used to enhance the efficacy of strengthening protocols. Muscle Nerve 54: 469-478, 2016. | yes |
26,872,827 | Do genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms? | {
"contexts": [
"The multisubunit SIN3 complex is a global transcriptional regulator. In Drosophila, a single Sin3A gene encodes different isoforms of SIN3, of which SIN3 187 and SIN3 220 are the major isoforms. Previous studies have demonstrated functional non-redundancy of SIN3 isoforms. The role of SIN3 isofor... | These data establish the role of SIN3 isoforms in regulating distinct biological processes. This study substantially contributes to our understanding of the complexity of gene regulation by SIN3. | yes |
26,873,528 | Is elevated TNF-α associated with pain and physical disability in mucopolysaccharidosis types I , II , and VI? | {
"contexts": [
"Children and adults with the lysosomal storage diseases mucopolysaccharidosis (MPS) types I, II and VI live shortened lives permeated by chronic pain and physical disability. Current treatments do not alleviate these problems. Thus there is a critical need to understand the mechanism of chronic p... | Higher TNF-α levels are implicated in the pain and decreased physical function present in individuals with MPS despite treatment with ERT and/or HCT, suggesting that TNF-a inhibition could potentially be a useful adjunctive therapy. Further investigation into the role of TNF-α inhibition in MPS to decrease pain and imp... | yes |
26,853,806 | Is migraine related to an increased risk of Parkinson 's disease : A population-based , propensity score-matched , longitudinal follow-up study? | {
"contexts": [
"The association between migraine and Parkinson's disease (PD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether migraineurs are at a higher risk of developing PD.",
"A total of 41,019 subjects aged between 4... | This study showed an increased risk of developing PD in patients with migraine. | yes |
26,865,835 | Is mutation pattern an influential factor on functional mutation rates in cancer? | {
"contexts": [
"Mutation rates are consistently varied in cancer genome and play an important role in tumorigenesis, however, little has been known about their function potential and impact on the distribution of functional mutations. In this study, we investigated genomic features which affect mutation pattern ... | Somatic mutation densities vary largely across cancer genome, mutation frequency is a major indication of function and influence on the distribution of functional mutations in cancer. | yes |
26,876,350 | Does aggregatibacter actinomycetemcomitans-Induced AIM2 Inflammasome Activation be Suppressed by Xylitol in Differentiated THP-1 Macrophages? | {
"contexts": [
"Aggressive periodontitis is characterized by rapid destruction of periodontal tissue caused by Aggregatibacter actinomycetemcomitans. Interleukin (IL)-1β is a proinflammatory cytokine, and its production is tightly regulated by inflammasome activation. Xylitol, an anticaries agent, is anti-inflam... | A. actinomycetemcomitans induced IL-1β production and AIM2 inflammasome activation. Xylitol inhibited these effects, possibly by suppressing internalization of A. actinomycetemcomitans into cells. Thus, this study proposes a mechanism for IL-1β production via inflammasome activation and discusses a possible use for xyl... | yes |
26,873,460 | Is strain echocardiography related to fibrosis and ventricular arrhythmias in hypertrophic cardiomyopathy? | {
"contexts": [
"Hypertrophic cardiomyopathy (HCM) patients are at risk of ventricular arrhythmias (VAs). We aimed to explore whether systolic function by strain echocardiography is related to VAs and to the extent of fibrosis by cardiac magnetic resonance imaging (CMR).",
"We included 150 HCM patients and 50... | GLS, mechanical dispersion, and LGE were markers of VAs in HCM patients. Mechanical dispersion was a strong independent predictor of VAs and related to the extent of fibrosis. Strain echocardiography may improve risk stratification of VAs in HCM. | yes |
26,857,093 | Does genome-wide association study in mice identify loci affecting liver-related phenotypes including Sel1l influencing serum bile acids? | {
"contexts": [
"Using publicly available data from inbred mouse strains, we conducted a genome-wide association study to identify loci that accounted for liver-related phenotypes between C57BL/6J and A/J mice fed a Paigen diet. We confirmed genome-wide significant associations for hepatic cholesterol (chromosome... | Genetic analyses of inbred mouse strains identified loci affecting different liver-related traits and implicated Sel1l as a significant determinant of serum bile acid concentration. (Hepatology 2016;63:1943-1956). | yes |
26,857,113 | Does platelet activation independent of pulmonary inflammation contribute to diesel exhaust particulate-induced promotion of arterial thrombosis? | {
"contexts": [
"Accelerated thrombus formation induced by exposure to combustion-derived air pollution has been linked to alterations in endogenous fibrinolysis and platelet activation in response to pulmonary and systemic inflammation. We hypothesised that mechanisms independent of inflammation contribute to ac... | DEP accelerates arterial thrombus formation through increased platelet activation. This effect is dissociated from pulmonary and systemic inflammation and from impaired fibrinolytic function. | yes |
26,866,618 | Does gaAlAs laser-induced pulp mineralization involve dentin matrix protein 1 and osteopontin expression? | {
"contexts": [
"GaAlAs lasers induce pulp mineralization by promoting reparative dentinogenesis. This study analyzed the expression of dentin matrix protein 1 (DMP1) and osteopontin in GaAlAs laser-irradiated rat molars, to examine the hypothesis that these proteins play a role in the laser-induced reparative de... | GaAlAs laser irradiation of rat molars induced upregulated DMP1 and osteopontin mRNA expression in the coronal pulp, followed by the formation of reparative dentin and the colocalization of DMP1 and osteopontin immunoreactivity at the site at which this tissue first appeared. | yes |
26,866,610 | Does caffeine prevent Hyperoxia-Induced Functional and Structural Lung Damage in Preterm Rabbits? | {
"contexts": [
"Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most common complication of extreme preterm birth.",
"To study the inflammatory, structural and functional effects of caffeine in an anim... | In preterm rabbits, caffeine reduces the functional, architectural and inflammatory pulmonary changes induced by hyperoxia in the lung. | yes |
26,877,239 | Do stimulated echo diffusion weighted imaging of the liver at 3 Tesla? | {
"contexts": [
"Diffusion time (Δ) effect in diffusion measurements has been validated as a sensitive biomarker in liver fibrosis by rat models. To extend this finding to clinical study, a reliable imaging technique is highly desirable. This study aimed to develop an optimal stimulated echo acquisition mode (STE... | The results verified the Δ dependence in diffusion measurements, indicating restricted diffusion in healthy human livers for the first time at 3T. This prepared STEAM DWI a potential technique for liver fibrotic studies in clinical practice. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc. | yes |
26,878,864 | Are nailfold videocapillaroscopy and serum VEGF levels in scleroderma associated with internal organ involvement? | {
"contexts": [
"Nailfold videocapillaroscopy (NVC) identifies the microvascular hallmarks of systemic sclerosis (SSc) and vascular endothelial growth factor (VEGF) and may play a pivotal role in the associated vasculopathy. The aim of the present study was to compare NVC alterations with clinical subsets, intern... | Our data suggest the importance of NVC not only for the diagnosis, but also for the global evaluation of SSc patients. Of note, serum VEGF levels may act as a biomarker of interstitial lung involvement. | yes |
26,864,934 | Is aNGPTL8/Betatrophin R59W variant associated with higher glucose level in non-diabetic Arabs living in Kuwaits? | {
"contexts": [
"ANGPTL8 (betatrophin) has been recently identified as a regulator of lipid metabolism through its interaction with ANGPTL3. A sequence variant in ANGPTL8 has been shown to associate with lower level of Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL). The objective of this study i... | Our data shows for the first time that heterozygote form of ANGPTL8 Rs.2278426 variant was associated with higher FBG level in Arabs highlighting the importance of these variants in controlling the function of betatrophin. | yes |
26,855,250 | Are early detection of type 2 diabetes mellitus and screening for retinopathy associated with reduced prevalence and severity of retinopathy? | {
"contexts": [
"To explore whether the prevalence and severity of retinopathy differ in diabetes cohorts diagnosed through screening as compared with conventional health care.",
"A total of 257 diabetes patients, 151 detected through screening and 106 through conventional clinical care, were included. Retino... | Among patients with screening-detected diabetes, the prevalence of retinopathy and increasing severity of retinopathy were significantly lower than among those who had their diabetes diagnosed through conventional care, even when other risk factors for retinopathy such as duration, hyperglycaemia and blood pressure wer... | yes |
26,856,334 | Is tGF-β signaling activated in patients with chronic HBV infection and repressed by SMAD7 overexpression after successful antiviral treatment? | {
"contexts": [
"Although animal studies demonstrated that Smad7 induction ameliorates TGF-β/SMAD-mediated fibrogenesis, its role in human hepatic diseases is rather obscure. Our study explored the activation status of TGF-β/activin pathway in patients with chronic liver diseases, and how it is affected by succes... | SMAD7 overexpression might represent a mechanism limiting TGF-β-mediated fibrogenesis in human hepatic diseases; therefore, SMAD7 induction likely represents a candidate for novel therapeutic approaches. | yes |
26,874,357 | Is the proteolytic activity of pregnancy-associated plasma protein-A potentially regulated by stanniocalcin-1 and -2 during human ovarian follicle development? | {
"contexts": [
"Is the proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) regulated by the stanniocalcins (STC1 and STC2) during human follicle maturation?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Adult",
"Chorionic Gonadotropin",
"Female",
"Fertility Preservati... | The STCs and PAPP-A show similar expression by immunohistochemistry in developing follicles, and regulation of PAPP-A proteolytic activity is suggested by the identification of inhibited protein complexes between PAPP-A and STC1 or STC2 in human follicular fluid (FF). | yes |
26,874,350 | Does transportome Profiling identify Profound Alterations in Crohn 's Disease Partially Restored by Commensal Bacteria? | {
"contexts": [
"Several transport alterations have been described in intestinal inflammatory diseases. This is relevant because the primary function of the intestine is nutrient and mineral absorption. However, analysis of the transportome as a whole and the effect of commensal bacteria on it have not been addre... | These results describe the altered transportome profile in CD and open the possibility of restoring transportome complications with commensal bacteria. | yes |
26,851,165 | Does implantation of healthy matrix-embedded endothelial cells rescue dysfunctional endothelium and ischaemic tissue in liver engraftment? | {
"contexts": [
"Liver transplantation is limited by ischaemic injury which promotes endothelial cell and hepatocyte dysfunction and eventually organ failure. We sought to understand how endothelial state determines liver recovery after hepatectomy and engraftment.",
"Matrix-embedded endothelial cells (MEECs)... | Implants with healthy endothelial cells rescue liver donor and recipient endothelium and parenchyma from ischaemic injury after major hepatectomy and engraftment. This study highlights endothelial-hepatocyte crosstalk in hepatic repair and provides a promising new approach to improve regenerative medicine outcomes and ... | yes |
26,854,998 | Does maternal periodontitis decrease plasma membrane GLUT4 content in skeletal muscle of adult offspring? | {
"contexts": [
"The fetal programming hypothesis suggests that intrauterine stimuli can induce metabolic changes in offspring, increasing the disease risk in adulthood. Periodontal disease may enhance serum cytokine levels. Cytokines such as tumor necrosis factor-alpha (TNF-α) have been associated with reduced g... | Maternal periodontal disease causes LBW, insulin resistance, and alterations in the final stage of insulin signaling in the GSM of adult offspring. | yes |
26,855,722 | Does a Live Vector Expressing HPV16 L1 generate an Adjuvant-Induced Antibody Response In-vivo? | {
"contexts": [
"The association between human papillomavirus (HPV) infections and cervical cancer has suggested the design of prophylactic and therapeutic vaccines against genital warts. The HPV capsid has made of two L1 and L2 coat proteins that have produced late in viral infections. Regarding to the recent st... | The recombinant live vector was able to induce humoral immunity in mice without need of any adjuvant. However, further studies have required to increase its efficiency. | yes |
26,871,397 | Do human classical monocytes display unbalanced M1/M2 phenotype with increased atherosclerotic risk and presence of disease? | {
"contexts": [
"Specific monocyte and macrophage subsets have been implicated in atherosclerosis, with intermediate monocytes proportionally elevated in cardiovascular disease and M1 macrophages abundant in unstable atherosclerotic plaques. While several studies have shown altered proportions of these subsets in... | We conclude that monocyte subsets show functional and phenotypic changes in cardiovascular disease and such changes are likely to contribute to atherosclerotic progression. | yes |
26,867,324 | Do [ The Relationship Between the Damages of Hand Functions and the Type of Cerebral Palsy in Children ]? | {
"contexts": [
"To investigate the relationship between the damages of hand functions and the type of cerebral palsy (CP) in children with CP.",
"A total of 280 children aged 4-12 years old with CP in the 20 districts of Chengdu were included. The damages of hand functions were assessed with the Chinese Vers... | There was a correlation between the MACS and the type of CP which can be used to determine the damaged condition of hand functions and develop the program of rehabilitation and the measures of classification management for the chidren with CP. | yes |
26,851,648 | Are serum fetuin-A levels independently correlated with vascular endothelial growth factor and C-reactive protein concentrations in type 2 diabetic patients with diabetic retinopathy? | {
"contexts": [
"The higher expression of vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) is associated with the development of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM). Fetuin-A is shown to have proangiogenic and proinflammatory effects.",
"This study included 245 T... | Serum fetuin-A concentrations are independently correlated with VEGF and CRP concentrations in T2DM patients with DR, but not in NDR subjects. | yes |
26,870,807 | Is arterial Blood , Rather Than Venous Blood , a Better Source for Circulating Melanoma Cells? | {
"contexts": [
"CTCs provide prognostic information and their application is under investigation in multiple tumor types. Of the multiple variables inherent in any such process, none is more important to outcome than the appropriateness of the sample source. To address this question, we investigated CTCs in pair... | Our data indicate that arterial blood specimens might be a better source of circulating uveal melanoma cells. Although less conveniently processed, perhaps arterial blood should be evaluated as sample source for measurement of CTCs. | yes |
26,848,888 | Does multicomponent Fitness Training improve Walking Economy in Older Adults? | {
"contexts": [
"Walking economy declines with increasing age, possibly leading to mobility limitation in older adults. Multicomponent fitness training could delay the decline in walking economy.",
"This study aimed to determine the effect of multicomponent fitness training on walking economy in older adults.... | Multicomponent fitness training decreases walking cost in older adults, preserving walking economy. Thus, training programs could delay mobility limitation with increasing age. | yes |
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