pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
16,389,167 | Is urinary creatinine concentration inversely related to glycaemic control and the presence of some diabetic complications in patients with newly diagnosed Type 2 diabetes? | {
"contexts": [
"The ratio between urinary albumin concentration (UAC) and urinary creatinine concentration (UCC) is widely used to estimate renal involvement. We examined how UAC and UCC associate with each other, with other risk factors, and with diabetic complications in a population-based sample of Type 2 dia... | The use of albumin/creatinine ratio (ACR) may introduce bias of unpredictable size and direction in comparisons of ACR with variables that are associated with UCC in their own right. In daily clinical practice, renal involvement in the individual patient can be estimated reliably with UAC or ACR measured in a freshly v... | yes |
16,391,298 | Is antibody immunity to the p53 oncogenic protein a prognostic indicator in ovarian cancer? | {
"contexts": [
"Presence of intratumoral T-cell infiltration has been linked to improved survival in ovarian cancer patients. We questioned whether antibody immunity specific for ovarian cancer tumor antigens would predict disease outcome. We evaluated humoral immune responses against ovarian cancer antigens p53... | Data presented here demonstrate that advanced stage ovarian cancer patients can have detectable tumor-specific antibody immunity and that immunity to p53 may predict improved overall survival in patients with advanced-stage disease. | yes |
16,392,343 | Does revascularization of autogenous block graft with or without an e-PTFE membrane? | {
"contexts": [
"The aim of this study was to describe the revascularization process of autogenous bone block grafts placed with or without an expanded polytetrafluoroethylene (e-PTFE) membrane.",
"Thirty Wistar male rats had their mandibles augmented by either an autogenous bone block graft (group A) or an a... | The results emphasized the importance of the vascular network and of the revascularization process of the autogenous bone graft in new bone formation. Early vascular penetration and nutrition of the graft are key factors in its integration with the recipient bed. | yes |
16,392,344 | Do in vitro evaluation of bacterial leakage along the implant-abutment interface of different implant systems? | {
"contexts": [
"Microbial leakage and colonization between implants and their abutments may cause inflammatory reactions in the peri-implant tissues. This study evaluated microbial leakage at the implant-abutment interface with a new in vitro model.",
"Bacterial leakage was tested during dynamic loading in a... | The degree of penetration in a specific implant system presumably is a multifactorial condition dependent on the precision of fit between the implant and the abutment, the degree of micromovement between the components, and the torque forces used to connect them. | yes |
16,392,347 | Are bone mineral density and bone histomorphometry statistically related? | {
"contexts": [
"The aim of this study was to evaluate how closely analysis of bone quality performed using the bone mineral density (BMD) values obtained by quantitative computerized tomography (QCT) reflected the histologic bone density.",
"Eighteen patients requiring implant therapy underwent CT scanning. ... | The results of this study support the use of QCT to assess the bone quality before implant placement to improve the planning of implant treatment. | yes |
16,401,419 | Do mscS-like proteins control plastid size and shape in Arabidopsis thaliana? | {
"contexts": [
"Mechanosensitive (MS) ion channels provide a mechanism for the perception of mechanical stimuli such as sound, touch, and osmotic pressure. The bacterial MS ion channel MscS opens in response to increased membrane tension and serves to protect against cellular lysis during osmotic downshock. MscS... | Our data support a model wherein MSL2 and MSL3 control plastid size, shape, and perhaps division during normal plant development by altering ion flux in response to changes in membrane tension. We propose that MscS family members have evolved new roles in plants since the endosymbiotic event that gave rise to plastids. | yes |
16,380,612 | Are cerebral microbleeds common in ischemic stroke but rare in TIA? | {
"contexts": [
"In patients with stroke, gradient-echo MRI commonly detects microbleeds, indicating small artery disease with increased risk of macroscopic intracranial bleeding. Antithrombotic treatments are frequently prescribed after TIA and stroke, but there have been no previous studies of microbleeds in TI... | Microbleeds are common in ischemic stroke but rare in TIA, an observation not explained by differences in vascular risk factors or severity of white matter disease seen on T2 MRI. This finding has implications for the safety of antithrombotic therapy and clinical trial design in the two groups. Microbleeds may also be ... | yes |
16,387,056 | Does high-frequency QRS electrocardiogram predict perfusion defects during myocardial perfusion imaging? | {
"contexts": [
"Changes in high-frequency (HF) QRS components of the electrocardiogram (ECG) (150-250 Hz) are more sensitive than changes in conventional ST segments for detecting myocardial ischemia. We investigated the accuracy of 12-lead HF QRS ECG in detecting perfusion defects during adenosine tetrofosmin m... | Analysis of 12-lead HF QRS ECG is highly sensitive and reasonably specific for detecting perfusion defects during adenosine MPI stress tests and significantly more sensitive than analysis of conventional ST segments. | yes |
16,380,706 | Does the circadian rhythm of tryptophan in breast milk affect the rhythms of 6-sulfatoxymelatonin and sleep in newborn? | {
"contexts": [
"The hormone melatonin regulates the sleep and this pineal hormone is synthesized in the organism from the amino acid tryptophan. It is known that breast-fed babies have better sleep patterns and a better entrained sleep/wake cycle than bottle-fed babies (adapted formula).",
"To compare the ci... | A temporal relationship was observed between the circadian rhythm of 6-sulfatoxymelatonin of the exclusively breast-fed babies and that of tryptophan in the mother's milk. Acting this amino acid as a zeitgeber entrainment of the biological rhythms in the breast-fed infant. | yes |
16,381,368 | Is heated , humidified CO2 gas unsatisfactory for awake laparoscopy? | {
"contexts": [
"The necessity for general anesthesia represents an impediment to using a laparoscopic approach for some procedures that are otherwise performed with the patient under local anesthesia using a conventional open technique. Heating and humidifying the insufflation gas reportedly reduces perioperativ... | Heated, humidified CO2 gas insufflation does not reduce pain sufficiently to permit satisfactory performance of laparoscopy with local anesthesia, especially when full volume insufflation is required. Cold, dry helium gas produces no pain. The theory that cold, dry insufflation gas is a source of peritoneal pain during... | yes |
16,394,091 | Is increased serum resistin in nonalcoholic fatty liver disease related to liver disease severity and not to insulin resistance? | {
"contexts": [
"The recently discovered hormone resistin is linked to the development of insulin resistance, but direct evidence of resistin levels in humans with nonalcoholic fatty liver disease (NAFLD) is lacking.",
"We conducted this study to assess the relationship between serum resistin and NAFLD. We me... | Both NAFLD and obese patients had lower adiponectin levels, whereas leptin was increased only in the obese group. No correlation was found between resistin and high-sensitivity C-reactive protein, BMI, homeostasis model assessment, insulin, glucose, transaminases, and lipid values. A positive correlation was found betw... | yes |
16,376,700 | Do lifestyle risk factors predict healthcare costs in an aging cohort? | {
"contexts": [
"While the U.S. elderly population uses a disproportionate amount of healthcare resources, there is limited knowledge from prospective studies regarding the impact of lifestyle-related factors on costs in this group. The association was examined between smoking, drinking, exercise, body mass index... | Seniors who were leaner, smoked fewer cigarettes over a lifetime, reduced their smoking, or walked farther had significant subsequent cost savings compared to those with less-healthy lifestyle-related habits. | yes |
16,386,872 | Do [ Evaluation of duration for direct admission dispatch process in an urban area ]? | {
"contexts": [
"In France, when physicians in ambulances take care of patients, they report medical status to the dispatch centre. Then the dispatching physician search for the available and appropriate hospital service to agree in directly receiving the patient. We attempted to evaluate this direct admission di... | The average duration of direct admission dispatch process is acceptable. The increased duration of direct admission dispatch process in some pathology during summer may induce a risk for the patients. This problem will be improved only when the management of the available bed for emergency traumatology, will be impleme... | yes |
16,385,514 | Is pulmonary arterial hypertension a major mortality factor in diffuse systemic sclerosis , independent of interstitial lung disease? | {
"contexts": [
"To determine whether pulmonary arterial hypertension (PAH) is a prognostic factor for mortality in diffuse cutaneous systemic sclerosis (dcSSc), independent of interstitial lung disease (ILD).",
"ILD was diagnosed by high-resolution computed tomography and PAH (pulmonary arterial systolic pre... | These results indicate that, independent of ILD, PAH is a major prognostic factor for survival in dcSSc. | yes |
16,385,285 | Does hypertonic saline resuscitation after mesenteric ischemia/reperfusion induce ileal apoptosis? | {
"contexts": [
"We have previously demonstrated that hypertonic saline (HS) resuscitation decreased inflammation and mucosal injury after mesenteric ischemia/reperfusion (I/R). In contrast to I/R cell necrosis, apoptosis provides controlled cell death that minimizes inflammation. We therefore hypothesized that H... | HS resuscitation after mesenteric I/R significantly increased ileal mucosal apoptosis while decreasing mucosal injury and may represent a novel mechanism by which HS resuscitation after mesenteric I/R reduces inflammation and imparts protection to the gut. | yes |
16,385,286 | Does immunoglobulin a modulate inflammatory responses in an in vitro model of pneumonia? | {
"contexts": [
"Preservation of mucosal immunity has been shown to affect the risk and outcome of pneumonia in severely injured patients. Secretory immunoglobulin A (SIgA) is the principle humoral defense of mucosal surfaces in the body and has several antiinflammatory properties. Polymorphonuclear neutrophils (... | PMN cytotoxic potential was decreased by the presence of SIgA but not IgG in an in vitro model to simulate pneumonia in vivo. SIgA may not only function to protect against microbial invasion of mucosal surfaces, but may also protect against tissue injury from an exaggerated inflammatory response. | yes |
16,387,746 | Are pyridine N-oxide derivatives inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture? | {
"contexts": [
"Evaluation of a wide variety of pyridine N-oxide derivatives on their inhibitory activity against feline coronavirus (FIPV strain) and human SARS-CoV (Frankfurt strain-1) in cell culture.",
"FIPV and SARS-CoV were exposed to confluent Crandel feline kidney (CRFK) and simian kidney (Vero) cell... | A wide variety of pyridine N-oxide derivatives have been found to be inhibitory against feline coronavirus (FIPV strain) and human SARS-CoV (Frankfurt strain-1) in CRFK and simian kidney (Vero) cell cultures, respectively. The oxide part on the pyridine moiety proved indispensable for anti-coronavirus activity. The pot... | yes |
16,399,532 | Does increased myocardial performance index correlate with biopsy-proven rejection in pediatric heart transplant recipients? | {
"contexts": [
"To date, cardiac catheterization and endomyocardial biopsy have been considered the \"gold standard\" for rejection surveillance after heart transplantation. Factors such as patient size (i.e., infant transplantation), loss of vascular access after repeated catheterizations, and anesthesia requir... | In this series, increased LVMPI correlated with biopsy-proven rejection, and frequent serial assessments using this technique may provide a relatively sensitive non-invasive means of rejection surveillance after pediatric cardiac transplantation. False positive results may be encountered, likely due to alterations in d... | yes |
16,397,032 | Is expression of hepatoma-derived growth factor correlated with lymph node metastasis and prognosis of gastric carcinoma? | {
"contexts": [
"Hepatoma-derived growth factor (HDGF) is a unique nuclear/growth factor and might play an important role in the development and progression of carcinomas. In the present study, association of HDGF expression with recurrence and prognosis of gastric carcinoma was examined.",
"HDGF expression i... | HDGF expression level was shown to be a prognostic factor for gastric carcinoma. | yes |
16,397,034 | Does reduced expression of CAMTA1 correlate with adverse outcome in neuroblastoma patients? | {
"contexts": [
"A distal portion of 1p is frequently deleted in human neuroblastomas, and it is generally assumed that this region harbors at least one gene relevant for neuroblastoma development. A 1p36.3 commonly deleted region, bordered by D1S2731 and D1S214 has been defined. The present study surveys whether... | Our data suggest that assessment of CAMTA1 expression may improve the prognostic models for neuroblastoma and that it will be important to define the biological function of CAMTA1 in this disease. | yes |
16,377,501 | Is renal function well maintained after use of left renal vein graft for vascular reconstruction in hepatobiliary-pancreatic surgery? | {
"contexts": [
"Advanced hepatobiliary-pancreatic malignancy occasionally involves major vasculatures, such as the portal vein or the inferior vena cava, and complete removal of the tumor is required for longterm survival. We used a left renal vein graft to reconstruct resected vessels in some patients. In this ... | The left renal vein could be safely obtained and used for vascular reconstruction in resection of hepatobiliary-pancreatic malignancy without adverse effects on early and longterm renal function. | yes |
16,374,069 | Does basement membrane matrix modify cytokine interactions between lung cancer cells and fibroblasts? | {
"contexts": [
"Proliferation of fibroblasts (desmoplastic reaction) in the lung adenocarcinomas is an important phenomenon that correlates with metastases and poor prognosis. Because basement membranes are often involved in the desmoplastic areas and many cytokines have binding capacity to basement membrane mol... | These results suggest that the basement membrane acts as a barrier to the diffusion and a reservoir of cytokines secreted by cancer cells, and that the subsequent degradation of the basement membrane by cancer cells could release the stored cytokines and promote growth of fibroblasts. | yes |
16,374,068 | Is overexpression of cyclooxygenase-2 associated with a favorable prognostic phenotype in breast carcinoma? | {
"contexts": [
"Cyclooxygenase (COX) is the rate-limiting enzyme that catalyzes the conversion of arachidonic acid to prostaglandins. The purpose of the present study was to investigate the involvement of COX-2 protein in breast cancer biological behavior through its correlation with the well-known clinicopathol... | The current data suggest that increased expression of COX-2 may be related to breast carcinomas with less aggressive phenotype. This suggestion is further supported by the positive correlation between COX-2 and PPARgamma, since the latter is considered to be indicative of a less malignant phenotype of tumor cells. | yes |
16,386,062 | Does periodic direct current promote wound closure in an in vitro dynamic model of cell migration? | {
"contexts": [
"A prevailing paradigm is that electrical fields can promote cell migration and tissue healing. To further validate this paradigm, we tested the hypothesis that periodic direct current (DC) can enhance wound closure using an in vitro dynamic model of cell migration.",
"Layers of primary fibrob... | Contrary to the authors' expectations, they found that periodic DC did not promote wound closure, a finding that emphasizes the need to clarify the complex effects of electrical fields on migrating cells. | no |
16,389,647 | Does mixed hematopoietic molecular chimerism result in permanent transgene expression from retrovirally transduced hepatocytes in mice? | {
"contexts": [
"Cytotoxic immune elimination of transduced hepatocytes may limit gene therapy for inherited liver diseases. Using beta-galactosidase as a marker gene, we studied whether creation of mixed beta-galactosidase molecular hematopoietic chimerism could induce tolerance to beta-galactosidase-transduced ... | Creation of a molecular hematopoietic chimerism can result in transgene tolerance and evade immune rejection of retrovirally transduced hepatocytes. This strategy may be useful for hepatic inherited diseases in which the transgene product behaves as a non-self protein. | yes |
16,387,896 | Do liver and skeletal muscle lipids have differing fatty acid profiles in short-gut rats fed via parenteral nutrition? | {
"contexts": [
"In short-gut rats, we showed marked abnormalities in plasma lipid fatty acids using parenteral nutrition (PN) with lipid vs sham surgery rats. This suggests that either sensing or metabolism of parenteral lipid is abnormal in malabsorption. The goal of this study was to determine fatty acid profi... | Both the presence of short gut and type of PN led to increases in distal metabolites of fatty acids on omega:3 and omega:6 pathway in liver phospholipids but not in skeletal muscle during short-term PN feeding in rats. | yes |
16,387,897 | Does feeding an elemental diet vs a milk-based formula decrease intestinal mucosal growth in infant pigs? | {
"contexts": [
"We previously showed that the level of enteral nutrient intake determines the rate of intestinal growth in piglets. Our objective was to determine whether providing enteral nutrition in the form of elemental nutrients (glucose, amino acids, lipid [ED]) rather than cow's milk formula (lactose, pro... | We conclude that intestinal mucosal growth and villus morphology are similar in pigs fed ED and FORM, despite higher cell proliferation and protein synthesis rates and lower lactase activity with ED. This implies that elemental diets may be as trophic as polymeric formulas to simultaneously provide nutrition and a stim... | no |
16,385,231 | Is ethanol-induced sensitization to endotoxin in Kupffer cells dependent upon oxidative stress? | {
"contexts": [
"Activation of Kupffer cells by gut-derived endotoxin plays a pivotal role in alcoholic liver injury. On the other hand, it was reported that acute ethanol administration reduced activation of Kupffer cells. We found that Kupffer cells isolated from rat treated only once with ethanol were sensitiz... | Ethanol causes tolerance in the early phase after ethanol consumption, while sensitization was observed later. Both tolerance and sensitization were induced by gut-derived endotoxin. These findings indicate that ethanol-induced both tolerance and sensitization of Kupffer cells to endotoxin involve IRAK expression. Furt... | yes |
16,371,118 | Is soluble tissue factor a candidate marker for progression of microvascular disease in patients with Type 2 diabetes? | {
"contexts": [
"To determine the relationship between abnormalities in blood coagulation and prevalent or incident cardiovascular complications in Type 2 diabetes.",
"Prospective cohort study of 128 patients with Type 2 diabetes in whom blood samples were collected at baseline and after 1 year of follow-up. ... | Soluble TF is associated with existing microvascular and neurogenic complications in patients with Type 2 diabetes and is a candidate marker for progression of microvascular disease. | yes |
16,389,042 | Does n-acetyl-cysteine suppress amniotic fluid and placenta inflammatory cytokine responses to lipopolysaccharide in rats? | {
"contexts": [
"Maternal infections may induce placental, amniotic and, potentially, fetal inflammatory responses. As cytokine responses may be mediated by oxidative stress, we determined whether the antioxidant N-acetyl-cysteine (NAC), can attenuate maternally induced amniotic and placental cytokine responses t... | NAC inhibition of inflammatory responses may protect the fetus from potential long-term sequelae. | yes |
16,399,034 | Is fractional anisotropy higher in Heschl 's gyrus than in superior temporal gyrus in normal subjects? | {
"contexts": [
"The first Heschl's gyrus (HG) is believed to receive the core projection of the acoustic radiation. We examined if it were possible to differentiate the subcortical white matter of the HG from the superior temporal gyrus (STG) using diffusion tensor (DT) imaging.",
"The study was approved and... | The FA in the subcortical white matter of the HG was higher than that of the STG in both hemispheres. These changes in DT imaging may be accounted for by the presence of the auditory radiations. | yes |
16,398,778 | Does chronic fetal hypoxia increase activin A concentrations in the late-pregnant sheep? | {
"contexts": [
"To determine whether activin A concentrations are altered in chronic fetal hypoxemia and intrauterine fetal growth restriction (IUGR).",
"In vivo animal experimental model.",
"Department of Physiology, Monash University.",
"Chronically catherised fetal sheep in late pregnancy.",
"... | SUAL-induced IUGR and fetal hypoxaemia increases AF activin A. This may be an important adaptive or protective response to IUGR. | yes |
16,393,285 | Are blood oxidative stress markers unreliable markers of hepatic steatosis? | {
"contexts": [
"Non-alcoholic fatty liver disease (NAFLD) and viral hepatitis are associated with hepatic oxidative stress, which is partially dependent on the amount of hepatic fat.",
"To determine whether the circulating lipid and oxidative stress parameters could be non-invasive markers of hepatic steatos... | Standard blood oxidative stress markers do not predict the extent of hepatic steatosis as they probably do not accurately reflect intrahepatic oxidative stress. Serum lipid levels were best correlated with hepatic steatosis. | yes |
16,396,725 | Does spinal manipulative therapy reduce inflammatory cytokines but not substance P production in normal subjects? | {
"contexts": [
"To examine the effect of a single spinal manipulation therapy (SMT) on the in vitro production of inflammatory cytokines, tumor necrosis factor alpha, and interleukin (IL) 1beta, in relation to the systemic (in vivo) levels of neurotransmitter substance P (SP).",
"Sixty-four asymptomatic subj... | SMT-treated subjects show a time-dependent attenuation of LPS-induced production of the inflammatory cytokines unrelated to systemic levels of SP. This suggests SMT-related down-regulation of inflammatory-type responses via a central yet unknown mechanism. | yes |
16,373,278 | Are expression and activation of MMP -2 , -3 , -9 , -14 induced in rat colon after abdominal X-irradiation? | {
"contexts": [
"Colonic response to single-dose irradiation is characterized by epithelial denudation followed by restitution. Extracellular matrix (ECM) remodeling is involved in both of these phases. The aim of this study was to characterize the contribution of matrix metalloproteinases (MMPs) and of their sti... | This study brings new insights into ECM remodeling in the colon after exposure to ionizing radiation and highlights the role of MMP subtypes specialized in basement membrane degradation. | yes |
16,377,835 | Does documentation in medical records improve after a neurointensivist 's appointment? | {
"contexts": [
"Medical documentation is important for communication among health care professionals, research, legal defense, and reimbursement. Previous studies have indicated insufficient documentation by health care providers and resistance among physicians to comply with the new guidelines. Data in the inte... | Our findings suggest that a major change was implemented in the NICU regarding documentation after a neurointensivist was appointed. Although the direct or indirect impact of the appointment was not clarified, these preliminary data warrant a prospective ICU study, which should determine the exact variables that play a... | yes |
16,399,490 | Does genistein affect the expression of genes involved in blood pressure regulation and angiogenesis in primary human endothelial cells? | {
"contexts": [
"Several lines of evidence suggest that the dietary isoflavone genistein (Gen) has beneficial effects with regard to cardiovascular disease and in particular on aspects related to blood pressure and angiogenesis. The biological action of Gen may be, at least in part, attributed to its ability to a... | Our data indicate that physiologically achievable levels of Gen change the expression of mRNA encoding for proteins involved in the control of blood pressure under baseline conditions and reduce the angiogenic response to oxLDL in the endothelium. | yes |
16,376,749 | Do isovolumic but not ejection phase Doppler tissue indices detect left ventricular dysfunction caused by coronary stenosis? | {
"contexts": [
"Isovolumic acceleration (IVA) obtained by tissue Doppler echocardiography (TDE) is a sensitive and relatively load-independent index for assessing systolic ventricular function. IVA also has the ability to describe the force-frequency relationship during incremental atrial pacing in vivo.",
"... | IVA detects changes in global LV systolic function during LAD constriction and may be a useful clinical tool to diagnose ischemia. | yes |
26,850,462 | Does miR-155 Overexpression promote Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair? | {
"contexts": [
"miR-155 is an oncogenic miRNA that is often overexpressed in cancer and is associated with poor prognosis. miR-155 can target several DNA repair factors, including RAD51, MLH1, and MSH6, and its overexpression results in an increased mutation frequency in vitro, although the mechanism has yet to ... | Taken together, miR-155 overexpression drives an increase in mutation frequency via multifaceted impact on DNA damage response and DNA repair pathways. | yes |
26,848,486 | Is therapy with natalizumab associated with high JCV seroconversion and rising JCV index values? | {
"contexts": [
"The aim of the study was to analyze John Cunningham virus (JCV) serology in natalizumab-treated patients over time and assess whether they are influenced by natalizumab treatment.",
"German (n = 1,921; 525 longitudinally) and French (n = 1,259; 711 longitudinally) patients were assessed for J... | JCV seroconversion and index values may be influenced by treatment with natalizumab. It is therefore important to monitor patients' JCV serology but also to incorporate additional risk factors into the progressive multifocal leukoencephalopathy risk stratification. | yes |
26,848,487 | Do patients with MS under daclizumab therapy mount normal immune responses to influenza vaccination? | {
"contexts": [
"The purpose of this study was to assess the potential immunosuppressive role of daclizumab, a humanized monoclonal antibody against the α chain of the interleukin 2 receptor, in vivo, by comparing immune responses to the 2013 seasonal influenza vaccination between patients with multiple sclerosis... | Despite the mild immunosuppressive effects of daclizumab in vivo demonstrated by an increased incidence of infectious complications in clinical trials, patients with MS under daclizumab therapy mount normal antibody responses to influenza vaccinations. | yes |
26,851,968 | Does multidimensional endotyping in patients with severe asthma reveal inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1? | {
"contexts": [
"Disease heterogeneity in patients with severe asthma and its relationship to inflammatory mechanisms remain poorly understood.",
"We aimed to identify and replicate clinicopathologic endotypes based on analysis of blood and sputum parameters in asthmatic patients.",
"One hundred ninety-fo... | In 2 distinct cohorts we have identified and replicated 6 clinicopathobiologic clusters based on blood and induced sputum measures. Our data underline a disconnect between clinical features and underlying inflammation, suggest IL-5 production is relatively steroid insensitive, and highlight the expression of YKL-40 in ... | yes |
26,854,462 | Do stem cells improve the quality of colonic anastomoses - A systematic review? | {
"contexts": [
"Stem cells have multiple ways of differentiating and restoring healing. This feature may recommend their usage for decreasing the incidence of anastomotic fistulas in the colon in case of colorectal malignancy.",
"To determine whether stem cells are improving digestive healing, we performed a... | These findings suggest a novel role for mesenchymal stem cells in digestive sutures on ischemic conditions. Although stem cells have shown their beneficial effect on anastomotic healing, further studies are necessary to establish the indications, the appropriate method of administration, the sampling site and the ident... | yes |
26,850,917 | Does nrf2 activator ameliorate hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation? | {
"contexts": [
"Oxidative stress has been reported to be a main cause of neuronal cell death in ischemia reperfusion injury (IRI). Nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important factor involved in anti-oxidative responses. We previously reported that bardoxolone methyl (BARD), an Nrf2 activat... | BARD suppressed the exacerbation hemorrhage caused by warfarin pretreatment and ameliorated BBB disruption by protecting endothelial cells, pericytes, and tight junction protein expressions. These results indicate that Nrf2 activators may be an effective therapy against hemorrhagic transformation caused by anticoagulan... | yes |
26,861,207 | Does feedback activation of neurofibromin terminate growth factor-induced Ras activation? | {
"contexts": [
"Growth factors induce a characteristically short-lived Ras activation in cells emerging from quiescence. Extensive work has shown that transient as opposed to sustained Ras activation is critical for the induction of mitogenic programs. Mitogen-induced accumulation of active Ras-GTP results from ... | Our findings show that, in addition to feedback inhibition of Sos, feedback stimulation of the RasGAP neurofibromin enforces termination of the Ras signal in the context of growth-factor signaling. These findings ascribe a precise role to neurofibromin in growth factor-dependent control of Ras activity and illustrate h... | yes |
26,850,918 | Does matrix metalloproteinase-9 deletion rescue auditory evoked potential habituation deficit in a mouse model of Fragile X Syndrome? | {
"contexts": [
"Sensory processing deficits are common in autism spectrum disorders, but the underlying mechanisms are unclear. Fragile X Syndrome (FXS) is a leading genetic cause of intellectual disability and autism. Electrophysiological responses in humans with FXS show reduced habituation with sound repetiti... | Fragile X Syndrome (FXS) is the leading known genetic cause of autism spectrum disorders. Individuals with FXS show symptoms of auditory hypersensitivity. These symptoms may arise due to sustained neural responses to repeated sounds, but the underlying mechanisms remain unclear. For the first time, this study shows def... | yes |
26,849,118 | Is conservative strategy in infantile fibrosarcoma possible : The European paediatric Soft tissue sarcoma Study Group experience? | {
"contexts": [
"Infantile fibrosarcoma (IFS) is a very rare disease occurring in young infants characterised by a high local aggressiveness but overall with a favourable survival. To try to reduce the total burden of therapy, the European pediatric Soft tissue sarcoma Study Group has developed conservative thera... | Conservative therapy is possible in IFS as only three children required mutilating surgery, and alkylating or anthracycline based chemotherapy was avoided in 71.0% of patients needing chemotherapy. VA regimen should be first line therapy in order to reduce long term effects. | yes |
26,861,901 | Do peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease? | {
"contexts": [
"To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically.",
"A prospective case-control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK a... | Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease. | yes |
26,850,513 | Do asymptomatic elite young tennis players show lateral and ventral growth plate alterations of proximal humerus on MRI? | {
"contexts": [
"The specific aim of the study was to investigate and compare epiphyseal length and extension in the proximal humerus, closure in the growth plate and bone marrow signal intensity related to the proximal humeral physis in the dominant arm and the non-dominant arm of the asymptomatic adolescent eli... | Significant findings assessing MRI measurements of the epiphyseal plate in the asymptomatic adolescent elite tennis player might reflect a development of consecutive alterations in the epiphyseal plate in the dominant arm. | yes |
26,854,258 | Is resistance to thrombomodulin associated with de novo portal vein thrombosis and low survival in patients with cirrhosis? | {
"contexts": [
"Portal vein thrombosis (PVT) is frequently observed in cirrhosis and may be a clinically important complication. In vitro assays for endogenous thrombin potential (ETP) demonstrated that in cirrhosis plasma has intrinsic resistance to the anticoagulant action of thrombomodulin (TM-R). This study ... | Owing to PVT results from the pro-coagulant imbalance occurring in patients with advanced cirrhosis, TM-R might serve as a predictor and could possibly be a biological mediator of adverse outcome in patients with advanced cirrhosis. | yes |
26,854,259 | Are thirty percent of abstracts presented at dental conferences published in full : a systematic review? | {
"contexts": [
"To review the publication fate of abstracts presented at dental conferences and investigate the association between full publication proportion (FPP) and abstract characteristics, conference characteristics, and methodological quality of primary studies.",
"PubMed, EMBASE, and Google Scholar ... | Less than one-third of abstracts presented at dental conferences were published in full more than 4 years after conference presentation. | yes |
26,874,031 | Do endothelin ETA receptors predominate in chronic thromboembolic pulmonary hypertension? | {
"contexts": [
"Endothelin-1 levels are raised in chronic thromboembolic pulmonary hypertension. Our aim in this study was to identify the presence of endothelin receptors in patients with CTEPH by analysing tissue removed at pulmonary endarterectomy.",
"Pulmonary endarterectomy tissue cross-sections were an... | The presence of ET-1 receptors in the chronic thrombus in proximal CTEPH suggests ET-1 could act not only on the distal vasculopathy in the unobstructed vessels but may also stimulate smooth muscle cell proliferation within chronic clot. The abundance of ET receptors within the tissue provides evidence that the ET path... | yes |
26,851,700 | Does intracoronary injection of tirofiban prevent microcirculation dysfunction during delayed percutaneous coronary intervention in patients with acute myocardial infarction? | {
"contexts": [
"To determine whether tirofiban can prevent microcirculation dysfunction during delayed percutaneous coronary intervention (PCI) of spontaneously recanalized and severe narrowing coronary artery in patients with acute myocardial infarction.",
"62 patients who have a single angiographically con... | Intracoronary injection of tirofiban can significantly prevent the abnormal increase of IMR value during delayed PCI in patients with acute myocardial infarction. | yes |
26,863,121 | Is early Trauma-Induced Coagulopathy Associated with Increased Ventilator-Associated Pneumonia in Spinal Cord Injury Patients? | {
"contexts": [
"Early trauma-induced coagulopathy may increase susceptibility to nosocomial infections such as ventilator-associated pneumonia. However, the relationship between trauma- induced coagulopathy and the development of ventilator-associated pneumonia in spinal cord injury patients has not been evaluat... | Coagulopathy on admission in patients with spinal cord injury is associated with a statistically significant increase in ventilator-associated pneumonia incidence. Additional research is warranted to further characterize this association. | yes |
26,875,070 | Does molecular Staging of Sentinel Lymph Nodes identify Melanoma Patients at Increased Risk of Nodal Recurrence? | {
"contexts": [
"Molecular staging of sentinel lymph nodes (SLNs) may identify patients who are node-negative by standard microscopic staging but are at increased risk for regional nodal recurrence; such patients may benefit from completion lymph node dissection (CLND).",
"In a multicenter, randomized clinica... | Patients with microscopically negative/PCR+ SLN have an increased risk of nodal recurrence that was mitigated by CLND. Although CLND did not affect OS, these data suggest that molecular detection of melanoma-specific mRNA in the SLN predicts a greater risk of nodal recurrence and deserves further study. | yes |
26,868,926 | Does interferon-γ enhance the efficacy of autogenous bone grafts by inhibiting postoperative bone resorption in rat calvarial defects? | {
"contexts": [
"Interferon (IFN)-γ is a major cytokine produced by immune cells that plays diverse roles in modulating both the immune system and bone metabolism, but its role in autogenous bone grafting remains unknown. Here, we present that local IFN-γ administration improved the efficacy of autogenous bone gr... | Local IFN-γ administration promoted bone formation in autogenous bone grafts possibly via regulating osteoclastogenesis and TNF-α expression. The data provide insights into the potential roles of IFN-γ in autogenous bone grafting. | yes |
26,855,770 | Is a novel mutation in CELSR1 associated with hereditary lymphedema? | {
"contexts": [
"Biological evidence reported in the literature supports the role of CELSR1 as being essential for valvular function in murine lymphatics. Yet thus far, there have been no variants in CELSR1 associated with lymphatic dysfunction in humans.",
"In this report, a rare early inactivating mutation ... | CELSRI may be responsible for primary, non-syndromic lymphedema in humans. | yes |
26,855,771 | Does a biophysical model of supercoiling dependent transcription predict a structural aspect to gene regulation? | {
"contexts": [
"Transcription in Escherichia coli generates positive supercoiling in the DNA, which is relieved by the enzymatic activity of gyrase. Recently published experimental evidence suggests that transcription initiation and elongation are inhibited by the buildup of positive supercoiling. It has therefo... | Our model, incorporating the supercoiling state of the gene, makes specific predictions that differ from previous models of gene expression. Genes in the same supercoiling domain influence the expression level of neighboring genes. Such structurally dependent regulation predicts correlations between genes in the same s... | yes |
26,867,523 | Does epidermal growth factor receptor inhibitor AG1478 inhibit mucus hypersecretion in airway epithelium? | {
"contexts": [
"Mucus hypersecretion and neutrophil infiltration are important characteristics of airway inflammation. Epidermal growth factor receptor (EGFR) transactivation induces mucus and inflammatory cytokine secretion from airway epithelial cells. To elucidate the roles of EGFR in airway inflammation, the... | These results indicated that EGFR transactivation plays an important role in mucin and IL-8 secretion from airway epithelial cells. Intranasal instillation of an EGFR tyrosine kinase inhibitor may be a new therapeutic approach for the treatment of upper airway inflammation. | yes |
26,870,786 | Does whole Genome Analysis of Injectional Anthrax identify Two Disease Clusters Spanning More Than 13 Years? | {
"contexts": [
"Anthrax is a rare disease in humans but elicits great public fear because of its past use as an agent of bioterrorism. Injectional anthrax has been occurring sporadically for more than ten years in heroin consumers across multiple European countries and this outbreak has been difficult to trace b... | Genome-based differentiation of injectional anthrax isolates argues for at least two separate disease events spanning > 12 years. The genomic similarity of the two clusters makes it likely that they are caused by separate contamination events originating from the same geographic region and perhaps the same site of drug... | yes |
26,870,789 | Is tuberculous Pericarditis Multibacillary and Bacterial Burden Drives High Mortality? | {
"contexts": [
"Tuberculous pericarditis is considered to be a paucibacillary process; the large pericardial fluid accumulation is attributed to an inflammatory response to tuberculoproteins. Mortality rates are high. We investigated the role of clinical and microbial factors predictive of tuberculous pericardit... | Patients with culture confirmed tuberculous pericarditis have a high bacillary burden, and this bacterial burden drives mortality. Thus proven tuberculosis pericarditis is not a paucibacillary disease. Moreover, the severe immunosuppression suggests limited inflammation. There is a need for the design of a highly bacte... | yes |
26,856,771 | Is cytologic atypia in the contralateral unaffected breast related to parity and estrogen-related genes? | {
"contexts": [
"The contralateral unaffected breast (CUB) of women with unilateral breast cancer provides a model for the study of breast tissue-based risk factors. Using random fine needle aspiration (rFNA), we have investigated hormonal and gene expression patterns related to atypia in the CUBs of newly diagno... | Cytologic atypia, and particularly anisonucleosis, is associated with recent and multiple births and ER negative status of the index tumor. Atypical samples showed increased expression of estrogen-related genes, consistent with the role of estrogen exposure in breast cancer development. | yes |
26,866,822 | Does ocular Fluid Analysis in Children reveal Interleukin-29/Interferon-λ1 as a Biomarker for Juvenile Idiopathic Arthritis-Associated Uveitis? | {
"contexts": [
"Childhood uveitis is a vision-threatening inflammatory eye disease commonly attributed to juvenile idiopathic arthritis (JIA). The pathogenesis is poorly understood, which makes clinical management challenging. We analyzed soluble mediators in ocular fluid (aqueous humor [AqH]) and serum from chi... | We identified IL-29/IFNλ1 as an intraocular biomarker for JIA-associated uveitis, which suggests that aberrant IFNλ signaling might be important in JIA-associated uveitis and distinct from other forms of childhood uveitis. | yes |
26,873,309 | Do glucocorticoid receptor polymorphisms modulate cardiometabolic risk factors in patients in long-term remission of Cushing 's syndrome? | {
"contexts": [
"Glucocorticoid receptor (GR) polymorphisms modulate glucocorticoid (GC) sensitivity and are associated with altered metabolic profiles.",
"To evaluate the presence of GR polymorphisms (BclI (rs41423247), N363S (rs56149945), ER22/23EK (rs6189/rs6190), and 9β (rs6198) and investigate their asso... | The 9β and BclI polymorphisms of the GR adversely affect the cardiometabolic profile in patients who are in remission after the treatment of CS. This suggests that genetically altered GC sensitivity modulates the long-term adverse cardiometabolic effects resulting from (endogenous) hypercortisolism. | yes |
26,869,963 | Is `` Food Addiction '' in Patients with Eating Disorders Associated with Negative Urgency and Difficulties to Focus on Long-Term Goals? | {
"contexts": [
"The present study aimed to investigate if eating disorder patients differ in specific personality traits depending on a positive screening of food addiction (FA) and to find a model to predict FA in eating disorder patients using measures of personality and impulsivity.",
"Two hundred seventy... | Eating disorder patients who have more problems to pursue tasks to the end and to focus on long-term goals seem to be more likely to develop addictive eating patterns. | yes |
26,851,533 | Does nicotine inhibit the production of proinflammatory cytokines of mice infected with coxsackievirus B3? | {
"contexts": [
"Although excessive sympathetic activation in viral myocarditis and the protective effects of sympathetic inhibition with β-blockers are clear, the effects of enhancing vagal tone on viral myocarditis remain unclear. In several models, vagus nerve activation with the α7 nicotinic acetylcholine rec... | The results indicate that cholinergic stimulation with nicotine significantly reduced the severity of viral myocarditis in mice. The findings suggest that alpha7 nAChR agonists may be a promising new strategy for patients with myocarditis. | yes |
26,860,892 | Does ponatinib attenuate experimental pulmonary arterial hypertension by modulating Wnt signaling and vasohibin-2/vasohibin-1? | {
"contexts": [
"An abnormal ratio of vasohibin-2/vasohibin-1 may be involved in the abnormal angiogenesis and vascular remodeling during pulmonary arterial hypertension (PAH).",
"To evaluate the pharmacological actions of Ponatinib (AP) in experimental model of PAH, the effects of AP on TGF-β1-mediated endot... | Our results identified a therapeutic potential of AP in PAH therapy might be modulated VASH-2/VASH-1 and the Wnt signaling. | yes |
26,863,584 | Are lactoferrin Levels in Tears Increased by the Topical Application of Diadenosine Tetraphosphate? | {
"contexts": [
"This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears.",
"Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples were collected by micropipette and lactoferrin was measured by... | Topical application of diadenosine tetraphosphate stimulates the secretion of lactoferrin in rabbit tears through P2 receptor activation. | yes |
26,868,993 | Is higher PDCD4 expression associated with obesity , insulin resistance , lipid metabolism disorders , and granulosa cell apoptosis in polycystic ovary syndrome? | {
"contexts": [
"To investigate the expression and clinical significance of programmed cell death 4 (PDCD4), a novel metabolism-associated gene, during polycystic ovary syndrome (PCOS) pathogenesis.",
"Case-control study.",
"University hospital.",
"A total of 77 PCOS patients and 67 healthy women as m... | Our study suggests for the first time that higher PDCD4 expression might play an important role in PCOS pathogenesis by affecting obesity, insulin resistance, lipid metabolism disorders, and GC apoptosis. | yes |
26,872,063 | Does missense Variant in MAPK Inactivator PTPN5 be Associated with Decreased Severity of Post-Burn Hypertrophic Scarring? | {
"contexts": [
"Hypertrophic scarring (HTS) is hypothesized to have a genetic mechanism, yet its genetic determinants are largely unknown. The mitogen-activated protein kinase (MAPK) pathways are important mediators of inflammatory signaling, and experimental evidence implicates MAPKs in HTS formation. We hypoth... | We report PTPN5 as a novel genetic locus associated with HTS severity. PTPN5 is a MAPK inhibitor expressed in neurons, suggesting a potential role for neurotrophic factors and neuroinflammatory signaling in HTS pathophysiology. | yes |
26,850,197 | Do gender and frailty predict poor outcomes in infrainguinal vascular surgery? | {
"contexts": [
"Women have poorer outcomes after vascular surgery as compared to men as shown by studies recently. Frailty is also an independent risk factor for postoperative morbidity and mortality. This study examines the interplay of gender and frailty on outcomes after infrainguinal vascular procedures.",
... | Female gender and frailty are both associated with increased risk of complications and death following infrainguinal vascular procedures with the highest risk in frail females. Further studies are needed to explore the mechanisms of interaction of gender and frailty and its effect on long-term outcomes for peripheral v... | yes |
26,857,874 | Does reasons for discrepancies in hip fracture risk estimate using FRAX and Garvan calculators? | {
"contexts": [
"Both the FRAX and Garvan calculators are used to estimate absolute risk of fracture, but they sometimes produce different estimates. We sought to determine which patient characteristics contribute to these discrepancies.",
"Ten-year hip fracture risk was estimated for 122 women, using both FR... | Hip fracture risk estimates are usually higher with Garvan than FRAX, and these differences could impact on treatment decisions in about a quarter of patients. Falls and multiple fractures have a strong influence on Garvan risk estimates, when present. Clinically important discrepancies tend to occur in patients who ar... | yes |
26,854,754 | Does an integrated molecular landscape implicate the regulation of dendritic spine formation through insulin-related signalling in obsessive-compulsive disorder? | {
"contexts": [
"Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with onset in childhood and is characterized by obsessions (recurrent, intrusive, persistent thoughts, impulses and/or ideas that often cause anxiety or distress) and compulsions (ritualized and stereotypic behaviours or mental ac... | This study is a first attempt to integrate molecuar information from different sources in order to identify biological mechanisms underlying OCD etiology. Our findings are constrained by the limited information from hypothesis-free studies and the incompleteness and existing limitations of the OCD literature and the ge... | yes |
26,872,549 | Do fractures lead to worsening of disease activity in rheumatoid arthritis? | {
"contexts": [
"The cause of rheumatoid arthritis (RA) flares is multifactorial and not well understood. No reports of fractures influencing disease activity in patients with RA have been published. The purpose of this study was to determine whether fractures influence disease activity in patients with RA.",
... | We have demonstrated that fractures influence disease activity in patients with RA. Larger numbers of fracture cases are required to confirm the present observations; however, the prevention of fracture is clearly required in patients with RA. | yes |
26,872,979 | Does microRNA-30a promote chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression? | {
"contexts": [
"MicroRNAs (miRNAs) play important roles in chondrogenic differentiation of mesenchymal stem cells (MSCs). However, the regulation of miR-30a during such process has not yet been well understood. The aim of the study was to investigate the effects of miR-30a on chondrogenic differentiation of MSCs... | Our results indicate that miR-30a acts as a key promoter for chondrogenic differentiation of MSCs by down-regulating DLL4 expression, and provide a novel insight on miRNA-mediated MSC therapy for cartilage-related disorders including osteoarthritis. | yes |
26,879,216 | Does decreased Cystatin C-Estimated Glomerular Filtration Rate be Correlated with Prolonged Hospital Stay in Transient Tachypnea of Newborn Infants? | {
"contexts": [
"Transient tachypnea of the newborn (TTN) is a benign disorder with a variable clinical course that often leads to hospitalization. The aim of this study was to assess and validate the relationship between the serum cystatin C level and symptom duration in infants with TTN.",
"Forty newborns p... | Tachypnea duration was shorter with higher Cys C-based eGFR in infants with TTN. | yes |
26,848,396 | Are high levels of cathepsin D and cystatin B associated with increased risk of coronary events? | {
"contexts": [
"The majority of acute coronary syndromes are caused by plaque ruptures. Proteases secreted by macrophages play an important role in plaque ruptures by degrading extracellular matrix proteins in the fibrous cap. Matrix metalloproteinases have been shown to be markers for cardiovascular disease whe... | The associations of cathepsin D and cystatin B with future CE provide clinical support for a role of these factors in cardiovascular disease, which for cathepsin D may be of particular importance for smokers. | yes |
26,858,793 | Does the MacNew Questionnaire be a Helpful Tool for Predicting Unplanned Hospital Readmissions After Coronary Revascularization? | {
"contexts": [
"The MacNew questionnaire is a neuro-behavioral tool which is easy and immediately usable. This self-reported questionnaire filled out by the patient allows the physician to achieve helpful information concerning the ways for optimizing the therapy and patient's lifestyles. In this retrospective s... | A relatively elevated MacNew global score appears to be associated with a significantly decreased risk of unscheduled hospitalizations after coronary revascularization over a 3-year follow-up. | yes |
26,850,359 | Does demethylation of tumor necrosis factor-α converting enzyme predict poor prognosis in acute-on-chronic hepatitis B liver failure? | {
"contexts": [
"Tumor necrosis factor-α converting enzyme (TACE) has been demonstrated to be involved in liver inflammation. However, the significance of TACE methylation in acute-on-chronic hepatitis B liver failure (ACHBLF) has not been demonstrated. This study aims to evaluate TACE methylation status in ACHBL... | This study showed that demethylation of TACE promoter occurred in ACHBLF and might serve as a potential prognostic marker. | yes |
26,856,989 | Does lRG1 modulate epithelial-mesenchymal transition and angiogenesis in colorectal cancer via HIF-1α activation? | {
"contexts": [
"Leucine-rich-alpha-2-glycoprotein 1 (LRG1) has been reported to be involved in several tumors, whether it participates in colorectal cancer (CRC) progression remains unclear. Here, we investigated the biological function and underlying molecular mechanisms of LRG1 in CRC.",
"The mRNA and prot... | The present study suggests that LRG1 plays a crucial role in the progression of CRC by regulating HIF-1α expression, thereby may be a promising therapeutic target of CRC. | yes |
26,851,052 | Is the face bow irrelevant for making prostheses and planning orthognathic surgery? | {
"contexts": [
"The author addresses whether the face bow is irrelevant for all types of prosthetic work and for planning orthognathic surgery.",
"The author searched electronic databases to find studies whose investigators used the strongest clinical evidence (that is, randomized clinical trials) and studie... | Eliminating the face bow transfer reduces the patient's chair time and the dentist's overhead expenses. The author found evidence in the results of randomized controlled trials and an online video that justify eliminating the use and teaching of the 133-year-old technique known as the face bow transfer. | yes |
26,869,066 | Does perioperative Dexamethasone Administration Increase the Incidence of Postoperative Infection in Total Hip and Knee Arthroplasty : A Retrospective Analysis? | {
"contexts": [
"Dexamethasone is frequently used for the treatment of postoperative nausea and vomiting and as an adjunct in multimodal postoperative analgesia after total joint arthroplasty; however, the incidence of periprosthetic joint infection (PJI) after the use of perioperative dexamethasone in total join... | A single intravenous perioperative dose of dexamethasone had no statistically significant difference in the rate of PJI after total hip or knee arthroplasty. | no |
26,866,868 | Does tissue-Engineered Skin Substitute enhance Wound Healing after Radiation Therapy? | {
"contexts": [
"When given in conjunction with surgery for treating cancer, radiation therapy may result in impaired wound healing, which, in turn, could cause skin ulcers. In this study, bilayer and monolayer autologous skin substitutes were used to treat an irradiated wound.",
"A single dose of 30 Gy of li... | These results indicate that BTESS is the preferred treatment for irradiated wound ulcers. | yes |
26,876,491 | Is cell phone use associated with an inflammatory cytokine profile of parotid gland saliva? | {
"contexts": [
"There is controversy on the effects of the non-ionizing radiation emitted by cell phones on cellular processes and the impact of such radiation exposure on health. The purpose of this study was to investigate whether cell phone use alters cytokine expression in the saliva produced by the parotid ... | The exposure of parotid glands to cell phones can alter salivary IL-10 and IL-1β levels, consistent with a pro-inflammatory microenvironment that may be related to heat production. | yes |
26,869,380 | Is placental MFSD2a transporter related to decreased DHA in cord blood of women with treated gestational diabetes? | {
"contexts": [
"Maternal-fetal transfer of docosahexaenoic acid (DHA) is impaired by gestational diabetes mellitus (GDM), but the underlying mechanisms are still unknown. MFSD2a was recently recognized as a lyso-phospholipid (lyso-PL) transporter that facilitates DHA accretion in brain. The role of this transpor... | In offspring of women with GDM treated either with diet or insulin, higher fetal fat accretion and lower placental MFSD2a contribute to reduce DHA availability. Lyso-PL appear to contribute to materno-fetal DHA transport. | yes |
26,853,239 | Does branched-chain amino acid supplementation attenuate a decrease in power-producing ability following acute strength training? | {
"contexts": [
"This study aimed to investigate the effects of branched-chain amino acid (BCAA) supplementation on recovery of power-producing ability following a strength training (ST) session.",
"Eleven resistance-trained males, performed baseline measures of a countermovement jump (CMJ) and a seated shot-... | BCAA administered acutely before and following intensive ST attenuates a decrease in power-producing ability experienced by resistance-trained males. The apparent small but significant effects on functional power suggest that BCAA is an effective ergogenic aid for athletes who require augmented recovery of power-produc... | yes |
26,879,479 | Is receptor for advanced glycation end products expressed on alveolar epithelial cells the main target for hyperoxia-induced lung injury? | {
"contexts": [
"Receptor for advanced glycation end products (RAGE) is abundantly expressed on alveolar epithelial cells (AECs) and participates in innate immune responses such as apoptosis and inflammation. However, it is unclear whether RAGE-mediated apoptosis of AECs is associated with hyperoxia-induced lung ... | These results indicated that RAGE on AECs mainly contributed to hyperoxia-induced lung injury and alveolar-capillary barrier disruption. | yes |
26,879,046 | Are isolated tumor cells in stage I & II colon cancer patients associated with significantly worse disease-free and overall survival? | {
"contexts": [
"Lymph node (LN) involvement represents the strongest prognostic factor in colon cancer patients. The objective of this prospective study was to assess the prognostic impact of isolated tumor cells (ITC, defined as cell deposits ≤ 0.2 mm) in loco-regional LN of stage I & II colon cancer patients."... | This study provides compelling evidence that ITC in stage I & II colon cancer patients are associated with significantly worse disease-free and overall survival. Based on these data, the presence of ITC should be classified as a high risk factor in stage I & II colon cancer patients who might benefit from adjuvant chem... | yes |
26,867,163 | Does human papillomavirus vaccination induce neutralising antibodies in oral mucosal fluids? | {
"contexts": [
"Mucosal human papillomaviruses (HPV) are a major cause of cancers and papillomas of the anogenital and oropharyngeal tract. HPV-vaccination elicits neutralising antibodies in sera and cervicovaginal secretions and protects uninfected individuals from persistent anogenital infection and associated... | We provide experimental proof that HPV-vaccination elicits neutralising antibodies to the vaccine-targeted types in oral fluids. Hence, immunisation may confer direct protection against type-specific HPV infection and associated diseases of the oropharyngeal tract. Measurement of antibodies in oral fluids represents a ... | yes |
26,855,236 | Does large Size Hemicraniectomy reduce Early Herniation in Malignant Middle Cerebral Artery Infarction? | {
"contexts": [
"Decompressive hemicraniectomy (DHC) reduces mortality and improves outcome after malignant middle cerebral artery infarction (MMI) but early in-hospital mortality remains high between 22 and 33%. Possibly, this circumstance is driven by cerebral herniation due to space-occupying brain swelling de... | Despite a more aggressive surgical approach, eDHC may reduce early in-hospital mortality and limit transtentorial herniation. Prospective studies are warranted to confirm our results and assess general safety of eDHC. | yes |
26,855,372 | Are failure of tooth eruption and brachydactyly in pseudohypoparathyroidism related to plasma parathyroid hormone-related protein levels? | {
"contexts": [
"Pseudohypoparathyroidism (PHP) is a genetic disorder characterized by resistance to the peripheral action of PTH due to maternally inherited heterozygous inactivating mutations in the coding sequence of Gsα or intronic regions of GNAS leading to aberrant splice variants (PHP1A), or methylation de... | We described the dental abnormalities in a large series of PHP patients that were followed in a single tertiary center. No relationship between plasma PTHrP levels and failure of tooth eruption, dental manifestations of PHP or brachydactyly was found. It is important that doctors pay attention to dental manifestations ... | no |
26,865,584 | Are adrenal-derived 11-oxygenated 19-carbon steroids the dominant androgens in classic 21-hydroxylase deficiency? | {
"contexts": [
"To comprehensively characterize androgens and androgen precursors in classic 21-hydroxylase deficiency (21OHD) and to gain insights into the mechanisms of their formation.",
"Serum samples were obtained from 38 patients (19 men) with classic 21OHD, aged 3-59, and 38 sex- and age-matched contr... | All four 11oxC19 steroids are elevated in both men and women with classic 21OHD. Our data suggest that 11oxC19 steroids are specific biomarkers of adrenal-derived androgen excess. | yes |
26,865,585 | Does diffuse parathyroid hormone expression in parathyroid tumors argue against important functional tumor subclones? | {
"contexts": [
"Primary hyperparathyroidism is usually characterized by a monoclonal parathyroid tumor secreting excess parathyroid hormone (PTH). The main regulator of PTH secretion is calcium and the calcium-PTH set point is shifted in parathyroid tumor cells. We sought to investigate the relationship between ... | No areas with apparently higher PTH expression were identified, perhaps suggesting that hyper functioning parathyroid tumor subclones should be rare. Circulating 25-hydroxyvitamin D levels may influence tumor PTH expression in vivo. If PTH immunoreactivity reflects the tumor calcium-PTH set point, our data imply that t... | yes |
26,853,120 | Does a Common Polymorphism in a Williams Syndrome Gene predict Amygdala Reactivity and Extraversion in Healthy Adults? | {
"contexts": [
"Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I, which is found within the WS microdeletion, have been associated wit... | A common polymorphism in the WS gene GTF2I associated with reduced social anxiety predicts decreased threat-related amygdala reactivity, which mediates an association between genotype and increased warmth in women. These results are consistent with reduced threat-related amygdala reactivity in WS and suggest that commo... | yes |
26,878,267 | Do community prevalence of long-term urinary catheters use in England? | {
"contexts": [
"To calculate the prevalence of long term catheter use in the community in two areas in the south and west of England.",
"People in England register with general practices to access health care through a National Health Service. Catheters are provided by prescription free of charge. In 2008, p... | Previous evidence on prevalence of long term catheter use is sparse, and of variable quality. The strength of this study is utilisation of a reliable source of data (catheter prescriptions) from a large population of patients. Neurourol. Urodynam. © 2016 Wiley Periodicals, Inc. | yes |
26,852,195 | Does subjective memory decline predict greater rates of clinical progression in preclinical Alzheimer 's disease? | {
"contexts": [
"The objective of this study was to determine the utility of subjective memory decline (SMD) to predict episodic memory change and rates of clinical progression in cognitively normal older adults with evidence of high β-amyloid burden (CN Aβ+).",
"Fifty-eight CN Aβ+ participants from the Austr... | High SMD is a harbinger of greater rates of clinical progression in preclinical AD. Although SMD reflects broader diagnostic implications for CN Aβ+, more sensitive measures may be required to detect early subtle cognitive change. | yes |
26,856,537 | Does inter-tissue coexpression network analysis reveal DPP4 as an important gene in heart to blood communication? | {
"contexts": [
"Inter-tissue molecular interactions are critical to the function and behavior of biological systems in multicellular organisms, but systematic studies of interactions between tissues are lacking. Also, existing studies of inter-tissue interactions are based on direct gene expression correlations,... | In summary, this is the first resource of human multi-tissue networks enabling the investigation of molecular inter-tissue interactions. With the networks in hand, we may systematically design combination therapies that simultaneously target multiple tissues or pinpoint potential side effects of a drug in other tissues... | yes |
26,872,978 | Are higher mitochondrial potential and elevated mitochondrial respiration associated with excessive activation of blood platelets in diabetic rats? | {
"contexts": [
"The high glucose concentration observed in diabetic patients is a recognized factor of mitochondrial damage in various cell types. Its impact on mitochondrial bioenergetics in blood platelets remains largely vague. The aim of the study was to determine how the metabolism of carbohydrates, which h... | Long-term diabetes can result in increased mitochondrial mass and may lead to hyperpolarization of blood platelet mitochondrial membrane. These alterations may be a potential underlying cause of abnormal platelet functioning in diabetes mellitus and hence, a potential target for antiplatelet therapies in diabetes. | yes |
26,876,958 | Is hAL-RAR ( Doppler guided haemorrhoid artery ligation with recto-anal repair ) a safe and effective procedure for haemorrhoids . Results of a prospective study after two-years follow-up? | {
"contexts": [
"To analyse prospectively results of HAL-RAR technique by evaluating pain, perioperative complications and clinical outcome after two years followup.",
"A prospective study design including 30 consecutive patients with haemorrhoids grade III-IV treated from June 2012. After discharge, patients... | HAL-RAR is safe and almost painless technique and it has very good results in the control of haemorrhoidal symptoms. This procedure should be considered as an effective first treatment option for haemorrhoids. | yes |
26,851,540 | Does sMicroRNA-1290 inhibit cells proliferation and migration by targeting FOXA1 in gastric cancer cells? | {
"contexts": [
"Gastric cancer is the third leading cause of cancer-related deaths in the world with high mortality rate due to the lack of markers in early detection and effective therapies. MicroRNAs (miRNAs), a critical part of epigenetic regulations in tumor, have been shown to be closely related to the init... | miR-1290 promotes gastric tumor cells proliferation and metastasis through FOXA1, which could be used as a marker for diagnosis and a target for therapeutic intervention. | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.