pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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18,571,029 | Do a novel stereolithographic surgical guide template for planning treatment involving a mandibular dental implant? | {
"contexts": [
"In recent years, the concept of prosthodontic-driven implantology has received more attention. The precise placement of implants in accordance with greater safety and confidence allow the practitioner to offer a safer, more secure and predictable treatment than could previously be provided. In th... | It was demonstrated that the versatility of the technique allows not only precise translation of the treatment plan to the patient's mouth, but also offers many additional significant benefits including use of special guides during surgery which would be difficult to achieve with traditional procedures. | yes |
18,550,916 | Do neural stem cells improve learning and memory in rats with Alzheimer 's disease? | {
"contexts": [
"We investigated whether neural stem cells (NSC) with transgenic expression of human nerve growth factor (hNGF) transplanted into the brain could offer a therapeutic option for the treatment of Alzheimer's disease (AD).",
"We infused okadaic acid into rat lateral ventricles to establish a chro... | The injection of okadaic acid into rat lateral ventricles constitutes a promising animal model for investigating selective aspects of AD. rAAV2-mediated hNGF delivery can render long-term and stable transduction of hNGF in NSC. NSC-hNGF-eGFP transplantation may offer a viable therapeutic approach for treatment of AD. | yes |
18,550,915 | Does hypermethylation-modulated downregulation of claudin-7 expression promote the progression of colorectal carcinoma? | {
"contexts": [
"The expression of tight junction-related transmembrane protein claudin-7 (CLDN7) and its regulatory mechanism were investigated in colorectal carcinomas (CRCs).",
"Methylation-specific polymerase chain reaction and treatment with the demethylating agent 5-aza-2'-deoxycytidine were conducted t... | These findings suggest that the CLDN7 gene silencing by promoter hypermethylation and the resultant reduction of CLDN7 expression may play an important role in the progression of CRCs. | yes |
18,556,568 | Is restoration of plasma von Willebrand factor deficiency sufficient to correct thrombus formation after gene therapy for severe von Willebrand disease? | {
"contexts": [
"Gene therapy for severe von Willebrand disease (vWD) seems an interesting treatment alternative with long-term therapeutic potential. We investigated the feasibility of targeting the liver for ectopic expression of physiologically active von Willebrand factor (vWF).",
"The capacity of transge... | High ectopic expression of transgene encoded plasma vWF can be obtained after gene transfer to the liver. Liver-expressed vWF was fully multimerized and able to restore proper platelet plug formation in severe vWD. The liver therefore seems an attractive target for gene therapy for severe vWD. | yes |
18,556,566 | Is triglyceride-rich lipoprotein-associated apolipoprotein C-III production stimulated by plasma free fatty acids in humans? | {
"contexts": [
"Insulin resistant states are associated with increased fatty acid flux to liver and intestine, which stimulates the production of triglyceride-rich lipoproteins (TRL). ApoC-III production and plasma and TRL concentrations are increased in insulin resistance and may contribute to the hypertriglyce... | These findings confirm that TRL apoC-III production is stimulated by an acute elevation of plasma FFAs, suggesting a novel regulatory pathway that may play a role in the overproduction of TRL apoC-III in insulin resistant states. | yes |
18,545,997 | Is cisplatin sensitivity of oral squamous carcinoma cells regulated by Na+ , K+-ATPase activity rather than copper-transporting P-type ATPases , ATP7A and ATP7B? | {
"contexts": [
"Cisplatin (CDDP) is one of the major chemotherapeutic drugs, but tumor cells' acquired resistance to CDDP limits its therapeutic potentials. One of the main reasons of resistance is reduced drug accumulation. The mechanism by which tumor cells accumulate reduced CDDP is not well elucidated yet. T... | Na(+),K(+)-ATPase activity is responsible for regulating intracellular CDDP accumulation in oral squamous carcinoma cells rather than Cu(2+)-ATPase. | yes |
18,549,934 | Are interleukin-6 and neutrophils associated with long-term survival after acute myocardial infarction? | {
"contexts": [
"Assessing acute myocardial infarction (MI) with respect to long-term survival is not easy. Authorities in the field suggest that inflammation predicts short-range (up to 17 months) coronary death. It is not known whether long-term survival is associated with the inflammatory response. In this stu... | Circulating IL-6 predicts long-term survival after acute MI. Neutrophils appear to have prognostic value as well. | yes |
18,551,723 | Does the herbicide flamprop-M-methyl have a new antimicrotubule mechanism of action? | {
"contexts": [
"The herbicidal mode of action of flamprop-M-methyl [methyl N-benzoyl-N-(3-chloro-4-fluorophenyl)-D-alaninate] was investigated.",
"For initial characterization, a series of bioassays was used, which indicated a mode of action similar to that of mitotic disrupter herbicides. Cytochemical fluor... | The results indicate that flamprop-M-methyl is a mitotic disrupter herbicide with a new antimicrotubule mechanism of action that affects orientation of spindle and phragmoblast microtubules, possibly by minus-end microtubule disassembly. | yes |
18,571,531 | Does the quality of the early motor repertoire in preterm infants predict minor neurologic dysfunction at school age? | {
"contexts": [
"The quality of a child's motor repertoire at age 3 to 4 months postterm is predictive of later cerebral palsy (CP). Its predictive power for minor neurologic dysfunction (MND) is unclear. This study aimed to investigate the predictive value of the quality of the early motor repertoire for the dev... | Assessment of the quality of the early motor repertoire can accurately identify individual infants at high and low risk for MND at school age. | yes |
18,554,396 | Does the metastasis-associated protein S100A4 exist in several charged variants suggesting the presence of posttranslational modifications? | {
"contexts": [
"S100A4 is a metastasis-associated protein which has been linked to multiple cellular events, and has been identified extracellularly, in the cytoplasm and in the nucleus of tumor cells; however, the biological implications of subcellular location are unknown. Associations between a variety of pos... | Endogenously expressed S100A4 were shown to exist in several charge variants, which indicates the presence of posttranslational modifications altering the net charge of the protein. The different variants were present in all subcellular compartments and tissues/cell lines examined, suggesting that the described charge ... | yes |
18,554,400 | Does a physical map of the heterozygous grapevine 'Cabernet Sauvignon ' allows map candidate genes for disease resistance? | {
"contexts": [
"Whole-genome physical maps facilitate genome sequencing, sequence assembly, mapping of candidate genes, and the design of targeted genetic markers. An automated protocol was used to construct a Vitis vinifera 'Cabernet Sauvignon' physical map. The quality of the result was addressed with regard t... | Despite some limitations that interfere with the correct assembly of heterozygous clones into contigs, the 'Cabernet Sauvignon' physical map is a useful and reliable intermediary step between a genetic map and the genome sequence. This tool was successfully exploited for a quick mapping of complex families of genes, an... | yes |
18,562,250 | Does acute opioid administration improve work-related exercise performance in patients with chronic back pain? | {
"contexts": [
"We studied the impact of acute opioid administration on work-related exercise performance in patients with chronic back pain. A double-blinded, random-order, placebo-controlled, crossover trial was conducted. Subjects were predominantly men (63%), with a mean age of 49 years. Subjects performed a... | This article presents the results of a clinical trial showing that acute opioid administration improves work-related exercise performance in individuals with chronic back pain. Longer trials of the effectiveness of opioid analgesia as an adjunct to functional restoration programs are recommended. | yes |
18,567,082 | Are fragile histidine triad gene alterations essential for hepatocellular carcinoma development in South Korea? | {
"contexts": [
"To establish the role of FHIT in the pathogenesis hepatocellular carcinoma (HCC).",
"We examined genomic alterations, as well as, mRNA and protein expression patterns from the FHIT gene, in 48 surgically resected hepatocellular carcinoma (HCC) tissues. Additionally, p53 mutations were analyze... | Aberrant FHIT transcripts were more common in HCC tissues as compared to non-cancerous liver tissues. However, Fhit expression was lost or reduced in a minor fraction of HCC tissues, while it was strongly expressed in non-cancerous liver tissues. Therefore, our study suggests that FHIT plays a role in relatively few HC... | no |
18,547,417 | Is pancreatobiliary versus intestinal histologic type of differentiation an independent prognostic factor in resected periampullary adenocarcinoma? | {
"contexts": [
"Resectable adenocarcinomas in the pancreatic head, by definition \"periampullary\", originate from ampullary, duodenal, biliary, or ductal pancreatic epithelium. Typically, periampullary adenocarcinomas have either intestinal or pancreatobiliary type of differentiation, and the type of differenti... | Pancreatobiliary versus intestinal type of differentiation independently predicts poor prognosis after pancreaticoduodenectomy for periampullary adenocarcinoma. Lymph node involvement, vessel infiltration, and increasing tumour diameter are adverse predictors of survival in tumours with pancreatobiliary differentiation... | yes |
18,561,952 | Does zinc aspartate alleviate lung injury induced by intestinal ischemia-reperfusion in rats? | {
"contexts": [
"Intestinal ischemia-reperfusion (II/R) induced acute lung injury is mediated by activated neutrophils and formation of free radicals. Several antioxidants have been shown to attenuate such remote organ injury. We studied the effects of zinc aspartate on lung injury induced by II/R in rats.",
... | Our results indicate that zinc aspartate alleviates lung injury induced by II/R attributable to its antioxidant and antiinflammatory effects. | yes |
18,552,385 | Are lysosome-related genes regulated in the orbital fat of patients with graves ' ophthalmopathy? | {
"contexts": [
"The molecular mechanism involved in the hypertrophy of the orbital fat in patients with Graves' ophthalmopathy or thyroid eye disease (TED) remains unclear. Comparison of genome-wide expression profiles may help in the search for the gene sets involved in TED.",
"Twenty-five orbital adipose t... | Lysosome-related genes, such as CLN2, CLN3, and HEXB, may be involved in the pathogenesis of adipose tissue hypertrophy in TED. | yes |
18,567,536 | Does subthalamic stimulation improve orienting gaze movements in Parkinson 's disease? | {
"contexts": [
"To determine the effect of subthalamic stimulation on visually triggered eye and head movements in patients with Parkinson's disease (PD).",
"We compared the gain and latency of visually triggered eye and head movements in 12 patients bilaterally implanted into the subthalamic nucleus (STN) f... | These results demonstrate that visually triggered saccades and orienting eye-head movements are impaired in the advanced stage of PD. In addition, subthalamic stimulation enhances amplitude and shortens latency of these movements. | yes |
18,544,273 | Are hyaluronan oligosaccharides potential stimulators to angiogenesis via RHAMM mediated signal pathway in wound healing? | {
"contexts": [
"To determine if oligosaccharides of hyaluronan (o-HA) promotes wound recovery by accelerating angiogenesis and to study the mechanisms by which o-HA stimulates endothelial cell (EC) proliferation.",
"Using hyaluronidase digestion, we prepared a mixture of hyaluronan (HA) fragments sizesd 2 to... | Hyaluronan oligosaccharides may play a role in wound healing by increasing angiogenesis. o-HA-RHAMM binding dependent signal transduction pathway may be important in the regulation of angiogenesis associated with EC proliferation. | yes |
18,549,495 | Does genomic mid-range inhomogeneity correlate with an abundance of RNA secondary structures? | {
"contexts": [
"Genomes possess different levels of non-randomness, in particular, an inhomogeneity in their nucleotide composition. Inhomogeneity is manifest from the short-range where neighboring nucleotides influence the choice of base at a site, to the long-range, commonly known as isochores, where a particu... | We demonstrate that the excess of strong local SS in pre-mRNAs is linked to the little explored phenomenon of genomic mid-range inhomogeneity (MRI). MRI is an interdependence between nucleotide choice and base composition over a distance of 20-1000 nt. Additionally, we have created a public computational resource to su... | yes |
18,563,480 | Is the number of metastatic lymph nodes a significant risk factor for bone metastasis and poor outcome after surgery for linitis plastica-type gastric carcinoma? | {
"contexts": [
"Linitis plastica-type gastric carcinoma remains a disease with poor prognosis despite an aggressive surgical approach. Although a prominent pattern of disease failure is peritoneal carcinomatosis, some patients experience rapid disease progression without signs of the peritoneal disease.",
"C... | Treatment strategy for the linitis plastica should in general combine surgery with aggressive treatment directed toward peritoneal disease. However, patients with >16 metastatic nodes more often are associated with bone metastasis than those with modest nodal involvement and suffer from poor prognosis. | yes |
18,558,180 | Does laser microdissection allow detection of abnormal gene expression in cystic adenomatoid malformation of the lung? | {
"contexts": [
"Congenital cystic adenomatoid malformation (CCAM) of the lung may result from a localized aberrant epithelial-mesenchymal interaction during lung development. We used laser microdissection (LMD) to isolate the epithelium and mesenchyme of CCAM, and studied candidate gene expression in these pure ... | LMD may be used to overcome the limitations of tissue heterogeneity in the study of CCAM. Abnormal growth factor expression may play a role in the etiology of this lesion. | yes |
18,558,181 | Does splenectomy reduce packed red cell transfusion requirement in children with sickle cell disease? | {
"contexts": [
"The purpose of the study was to measure the effect of splenectomy on packed-cell transfusion requirement in children with sickle cell disease.",
"Thirty-seven sickle cell children who underwent splenectomies between January 2000 and May 2006 at a children's hospital were reviewed. Data were c... | Laparoscopic splenectomy can be successfully completed in sickle cell children. Splenectomy significantly reduces the packed red cell transfusion requirement and frequency of clinic visits, in sickle cell children for at least 12 months postoperatively. | yes |
18,562,736 | Does perfusion MDCT enable early detection of therapeutic response to antiangiogenic therapy? | {
"contexts": [
"The objective of our study was to determine whether perfusion CT can be used to detect early changes in therapeutic response to antiangiogenic therapy in an animal tumor model.",
"Twenty-five rats implanted with R3230 mammary adenocarcinoma (diameter, 1.2-2.0 cm) randomly received 7.5 or 30 m... | Perfusion MDCT can detect focal blood flow changes even when the tumor is shrinking, possibly indicating early reversal of tumor responsiveness to antiangiogenic therapy. Given that changes in tumor volume after antiangiogenic therapy do not necessarily correlate with true treatment response, physiologic imaging of tum... | yes |
18,566,198 | Does total intravenous anesthesia with propofol augment the potency of mivacurium? | {
"contexts": [
"Little is known about the potentiating effect of propofol on neuromuscular blocking drugs. However, some animal studies indicate a dose-dependent increase of the potency of neuromuscular blocking drugs by propofol. This study compared mivacurium potency after five minutes and after 20 min of tota... | After 20 min of TIVA propofol, the potency of mivacurium is approximately 50% greater than after five minutes of TIVA propofol. For clinical purposes, it is important, therefore, to consider the duration of TIVA propofol before determining the dose of neuromuscular blocking drug. | yes |
18,548,617 | Is standardization of flow cytometric minimal residual disease evaluation in acute lymphoblastic leukemia : Multicentric assessment feasible? | {
"contexts": [
"Single-laboratory experience showed that flow cytometric (FCM) assessment of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) is feasible in most patients and gives independent prognostic information. It is, however, not known whether FCM analysis can reliably be standardized ... | MRD-evaluation by FCM in ALL can be standardized for reliable multicentric assessment in large trials. | yes |
18,558,276 | Is muscular tenderness in the anterior chest wall in patients with stable angina pectoris associated with normal myocardial perfusion? | {
"contexts": [
"This study examines the relationship between the existence of chest wall tenderness evoked by palpation and the absence of ischemic heart disease defined by myocardial perfusion imaging in patients with known or suspected stable angina pectoris.",
"Two hundred seventy-five patients were recru... | Presence of tenderness in the anterior chest wall is associated with a higher prevalence of normal myocardial perfusion imaging in patients with known or suspected angina pectoris, and this association cannot be explained by a common association to age, sex, or pain. | yes |
18,569,797 | Do treatment of serpiginous choroiditis with intravitreous fluocinolone acetonide implant? | {
"contexts": [
"To describe a case in which a fluocinolone acetonide implant was used in a patient with serpiginous choroiditis.",
"Case report.",
"A 57-year-old woman with active serpiginous choroiditis threatening the fovea of her right eye received one intravitreous triamcinolone acetonide injection, ... | Intravitreous fluocinolone acetonide implant should be recognized as a potential treatment option for serpiginous choroiditis. | yes |
18,570,297 | Is gray matter atrophy related to long-term disability in multiple sclerosis? | {
"contexts": [
"To determine the relation of gray matter (GM) and white matter (WM) brain volumes, and WM lesion load, with clinical outcomes 20 years after first presentation with clinically isolated syndrome suggestive of multiple sclerosis (MS).",
"Seventy-three patients were studied a mean of 20 years fr... | In MS patients with a relatively long and homogeneous disease duration, GM atrophy is more marked than WM atrophy, and reflects disease subtype and disability to a greater extent than WM atrophy or lesions. | yes |
18,571,164 | Do peroxisome proliferator-activated receptor-gamma and retinoid X receptor agonists synergistically suppress proliferation of immortalized endometrial stromal cells? | {
"contexts": [
"To examine whether trichostatin A (TSA), a histone deacetylase inhibitor (HDACI), can induce up-regulation of peroxisome proliferator-activating receptor gamma (PPAR gamma) and to see whether LG100268, a retinoid X receptor (RXR) ligand, can inhibit proliferation of endometriotic cells alone or i... | The up-regulation of PPAR gamma induced by TSA indicates that the action of HDACIs also includes the PPAR gamma signaling pathway, suggesting that the activation of PPAR gamma is a desirable way to contain endometriosis phenotypes. The higher sensitivity of endometriotic cells than their endometrial counterpart to LG10... | yes |
18,565,146 | Is peroxiredoxin I differentially expressed in multiple myelomas and in plasmablastic lymphomas? | {
"contexts": [
"Plasmablastic lymphoma (PBL) and multiple myeloma (MM) are B cell-derived malignancies that share many morphologic and immunophenotypic traits, making the differential diagnosis particularly complicated. We have recently demonstrated that peroxiredoxin I (PrdxI) is expressed in plasma cells but n... | We hypothesize PrdxI as a component of the unfolded protein response (UPR), an adaptive pathway essential for plasma cell differentiation. As we have not detected immunoglobulin in our PBL cases, we suggest that UPR was not activated in the cells, accounting for the impediment of the developmental process, and for the ... | yes |
18,552,255 | Is fasting serum ghrelin level associated with metabolic syndrome in peritoneal dialysis patients? | {
"contexts": [
"Serum ghrelin levels are elevated in uremic patients. However, no data are available on the relationship between metabolic syndrome and serum ghrelin levels in peritoneal dialysis (PD) patients.",
"Metabolic syndrome and its components were defined using diagnostic criteria recommended by the... | These results indicate an inverse association between circulating fasting ghrelin and metabolic syndrome in PD patients. Serum HDL was associated with serum ghrelin among PD patients. | yes |
18,559,734 | Does comparison of auditory brainstem response result in normal-hearing patients with and without tinnitus? | {
"contexts": [
"To evaluate electrophysiologically the auditory nerve and the auditory brainstem function of patients with tinnitus and normal-hearing thresholds using the auditory brainstem response (ABR).",
"Case-control study.",
"Ambulatory section of the Department of Otolaryngology, Hospital de Base... | We conclude that, although the averages obtained in several analyzed parameters were within normal limits, the ABR results from the patients with and without tinnitus and normal hearing are different, suggesting that ABR might contribute to the workup of these patients. Our data show that there are changes in the centr... | yes |
18,568,484 | Do personality and choice of coping predict quality of life in head and neck cancer patients during follow-up? | {
"contexts": [
"The aim of the present study was to investigate to what extent personality and choice of coping predicted self-reported quality of life (QoL) in successfully treated head and neck squamous cell carcinoma (HNSCC) patients.",
"We determined QoL by the European Organization for Research and Trea... | In conclusion, a high T stage, high neuroticism, coping by humor and coping by problem solving directly predicted low QoL whereas neuroticism was also associated with QoL through avoidance coping. | yes |
18,558,624 | Does fK778 ameliorate post-transplant expression of fibrogenic growth factors and development of chronic rejection changes in rat kidney allografts? | {
"contexts": [
"Acute rejection is the major risk factor for the development of subsequent chronic allograft nephropathy (CAN), which is the primary reason for late allograft loss in kidney transplantation. Platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) are the main mitogens... | These results indicate that FK778 could prevent the development of CAN and be a promising therapy also in clinical kidney transplantation. | yes |
18,563,961 | Are plasmodium vivax and mixed infections associated with severe malaria in children : a prospective cohort study from Papua New Guinea? | {
"contexts": [
"Severe malaria (SM) is classically associated with Plasmodium falciparum infection. Little information is available on the contribution of P. vivax to severe disease. There are some epidemiological indications that P. vivax or mixed infections protect against complications and deaths. A large mor... | P. vivax monoinfections as well as mixed Plasmodium infections are associated with SM. There is no indication that mixed infections protected against SM. Interventions targeted toward P. falciparum only might be insufficient to eliminate the overall malaria burden, and especially severe disease, in areas where P. falci... | yes |
18,545,985 | Does an endocannabinoid signaling system modulate anxiety-like behavior in male Syrian hamsters? | {
"contexts": [
"An endocannabinoid signaling system has not been identified in hamsters.",
"We examined the existence of an endocannabinoid signaling system in Syrian hamsters using neuroanatomical, biochemical, and behavioral pharmacological approaches.",
"The distribution of cannabinoid receptors was m... | Endocannabinoids engage functional CB1 receptors in hamster brain to suppress anxiety-like behavior and undergo enzymatic hydrolysis catalyzed by FAAH. Our results further suggest that neither unconditioned nor conditioned social defeat in the Syrian hamster is dependent upon cannabinoid CB1 receptor activation. | yes |
18,543,121 | Is the nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase associated to the risk of developing essential tremor? | {
"contexts": [
"We analyzed in patients with essential tremor (ET) the Thr105Ile polymorphism of the Histamine N-methyltransferase (HNMT) enzyme that is associated to Parkinson's disease (PD) risk.",
"Leukocytary DNA from 204 ET patients and a control group of 295 unrelated healthy individuals was studied fo... | These results, combined with previous findings indicating alterations in the frequency for the HNMT Thr105Ile polymorphism in patients with PD, suggest that alterations of histamine homeostasis in the SNC are associated with the risk of movement disorders. | yes |
18,547,287 | Does corticosteroid therapy increase membrane-tethered while decreases secreted mucin expression in nasal polyps? | {
"contexts": [
"Mucus hypersecretion is a hallmark of nasal polyposis (NP). Corticosteroids (CS) are first-line treatment for NP, decreasing their size and inflammatory component. However, their effect on mucin production is not well-understood. The aim of this (pilot) study was to investigate CS effect on mucin... | These results suggest: (i) CS up-regulate membrane (MUC1, MUC4) while down-regulate secreted (MUC5AC, MUC5B) mucins; (ii) there exists a link between secreted mucin expression and goblet cell hyperplasia; and (iii) NP from AIA may develop resistance to CS treatment. | yes |
18,547,288 | Does activation of peroxisome proliferator-activated receptor gamma suppress mast cell maturation involved in allergic diseases? | {
"contexts": [
"Mast cells play a central role in allergic and inflammatory diseases. Several reports indicated role of peroxisome proliferator-activated receptor gamma (PPARgamma) on mast cell function. However, there is no report about the role of PPARgamma on differentiation of mast cells from the progenitors... | Our results indicate that PPARgamma is one of master regulators on mast cell maturation and potentially useful for the therapy in various disorders involving mast cell activation. | yes |
18,548,955 | Do perceptions of outcomes of implant therapy in patients with ectodermal dysplasia syndromes? | {
"contexts": [
"The purpose of this study was to evaluate patient-specific outcomes and satisfaction using dental implants in a population affected with ectodermal dysplasia.",
"Patient-based data were collected using a self-reported survey instrument sent to patients belonging to a private patient foundatio... | Affected individuals receiving tooth replacement therapy with dental implants reported satisfaction with the outcome. A higher level of complications, including infection, mechanical problems, and implant loss, relative to the unaffected population was reported. | yes |
18,549,927 | Do dietary lipids modify redox homeostasis and steroidogenic status in rat testis? | {
"contexts": [
"The present study explored the effect of dietary oils on lipid composition, antioxidant status, and the activity of the main steroidogenic enzymes in the testis.",
"Forty Wistar rats were randomly assigned to one of four groups (n = 10) fed for 60 d on the same basal diet plus different lipid... | Different oils in the diets strongly modified the homeostasis of the testicular antioxidant defense system and, in consequence, affected steroidogenic function, showing a clear correlation with the damage induced. According to our results, an appropriate mixture of olive and soybean oils could be a healthy recommendati... | yes |
18,549,921 | Do novel cardiovascular risk factors completely explain the higher prevalence of peripheral arterial disease among African Americans . The San Diego Population Study? | {
"contexts": [
"This study was designed to determine whether novel cardiovascular disease (CVD) risk factors explain the high prevalence of peripheral arterial disease (PAD) among African Americans.",
"Compared with Caucasians, African Americans have higher prevalence of PAD, an association that is not expla... | Traditional and novel CVD risk factors only partially explain the higher prevalence of PAD among African Americans. | no |
18,547,412 | Does pichia stipitis xylose reductase help detoxifying lignocellulosic hydrolysate by reducing 5-hydroxymethyl-furfural ( HMF )? | {
"contexts": [
"Pichia stipitis xylose reductase (Ps-XR) has been used to design Saccharomyces cerevisiae strains that are able to ferment xylose. One example is the industrial S. cerevisiae xylose-consuming strain TMB3400, which was constructed by expression of P. stipitis xylose reductase and xylitol dehydroge... | We demonstrate for the first time that xylose reductase is also able to reduce the furaldehyde compounds that are present in undetoxified lignocellulosic hydrolysates. Possible implications of this newly characterized activity of Ps-XR on lignocellulosic hydrolysate fermentation are discussed. | yes |
18,554,389 | Does the pro-apoptotic K-Ras 4A proto-oncoprotein affect tumorigenesis in the ApcMin/+ mouse small intestine? | {
"contexts": [
"Alterations in gene splicing occur in human sporadic colorectal cancer (CRC) and may contribute to tumour progression. The K-ras proto-oncogene encodes two splice variants, K-ras 4A and 4B, and K-ras activating mutations which jointly affect both isoforms are prevalent in CRC. Past studies have e... | The K-Ras 4A proto-oncoprotein does not exhibit tumour suppressor activity in the small intestine, even though the K-ras 4A/4B ratio is reduced in adenomas lacking K-ras activating mutations. | no |
18,556,729 | Does smoking increase the risk of relapse after successful tuberculosis treatment? | {
"contexts": [
"Recent tobacco smoking has been identified as a risk factor for developing tuberculosis, and two studies which have investigated its association with relapse of tuberculosis after completion of treatment had conflicting results (and did not control for confounding). The objective of this study wa... | Our results establish that smoking is associated with relapse of tuberculosis even after adjustment for the socioeconomic variables. Smoking cessation support should be incorporated in the strategies to improve effectiveness of Tuberculosis Control Programs. | yes |
18,568,343 | Is pharmacogenetic effect of the UGT polymorphisms on mycophenolate modified by calcineurin inhibitors? | {
"contexts": [
"Mycophenolic acid (MPA) is glucuronidated primarily by uridine diphosphate glucuronosyltransferase enzymes (UGT) 1A9 and 1A8. These enzymes are highly polymorphic resulting in low activity and high expression phenotypes. We hypothesized that polymorphisms of UGT1A9 and 1A8 may alter MPA pharmacok... | The effect of UGT1A8 and UGT1A9 variants on MPA metabolism appears to be modified by concomitant calcineurin inhibitor therapy. Confirmatory in vivo and in vitro studies are needed. | yes |
18,554,414 | Does mild therapeutic hypothermia shorten intensive care unit stay of survivors after out-of-hospital cardiac arrest compared to historical controls? | {
"contexts": [
"Persistent coma is a common finding after cardiac arrest and has profound ethical and economic implications. Evidence suggests that therapeutic hypothermia improves neurological outcome in these patients. In this analysis, we investigate whether therapeutic hypothermia influences the length of in... | Therapeutic hypothermia was found to significantly shorten ICU stay and time of mechanical ventilation in survivors after out-of-hospital cardiac arrest. Moreover, profound improvements in both neurological outcome and 1-year survival were observed. | yes |
18,554,418 | Is mix of methods needed to identify adverse events in general practice : a prospective observational study? | {
"contexts": [
"The validity and usefulness of incident reporting and other methods for identifying adverse events remains unclear. This study aimed to compare five methods in general practice.",
"In a prospective observational study, with five general practitioners, five methods were applied and compared. T... | A mix of methods is needed to identify adverse events in general practice. | yes |
18,562,248 | Is myocardial scar detected by contrast-enhanced cardiac magnetic resonance imaging associated with ventricular tachycardia in hypertrophic cardiomyopathy patients? | {
"contexts": [
"Hypertrophic cardiomyopathy (HCM) is associated with myocardial scarring and ventricular tachycardia (VT). Contrast-enhanced cardiac magnetic resonance imaging (CE-CMR) can quantify myocardial scar, and scar imaging has been documented in patients with HCM. We investigated the assessment of myoca... | Myocardial scar imaged by CE-CMR is common in patients with HCM, and is predictive of VT. Scar is seen in all HCM variants, and is associated with maximal wall thickness. There may be a role for CE-CMR in improved risk stratification for individual patients with HCM. | yes |
18,572,246 | Is modulation of intracellular machinery by beta-glycolipids associated with alteration of NKT lipid rafts and amelioration of concanavalin-induced hepatitis? | {
"contexts": [
"The integrity of lipid rafts in cell membranes is important for signal transduction.",
"To determine the distinct effects of beta-glycolipids on the composition of lipid rafts in natural killer T (NKT) cells and on the level of expression of flotillin-2, leukocyte-specific protein tyrosine ki... | The alteration in the expression levels of flotillin-2, Lck, and STAT1 that occurs concomitantly with changes in lipid raft composition and structure following the administration of beta-glycolipids in ConA-induced hepatitis is microenvironment-dependent and is associated with decreased intrahepatic CD8(+) T lymphocyte... | yes |
18,548,824 | Is heavy snoring a risk factor for case fatality and poor short-term prognosis after a first acute myocardial infarction? | {
"contexts": [
"Sleep disordered breathing has been associated with an increased risk for developing coronary heart disease. Data on the effects of sleep disordered breathing on case fatality and prognosis of a myocardial infarction are sparse. The present study aimed to investigate a possible relationship of sn... | Heavy snoring is associated with case fatality and short-term mortality in patients with a first acute myocardial infarction. | yes |
18,548,825 | Does coronary blood flow become uncoupled from myocardial work during obstructive sleep apnea in the presence of endothelial dysfunction? | {
"contexts": [
"Patients with obstructive sleep apnea (OSA) and coronary artery disease have a poor long-term prognosis. It is unknown whether the coronary blood flow (CBF) response to OSA is appropriate for myocardial metabolic requirements. Therefore, CBF was assessed during OSA, before and after the developme... | Under baseline conditions, CBF correlates well with myocardial work following the termination of apnea in lambs. After the creation of coronary artery endothelial dysfunction with LPS, there is uncoupling of the normal CBF-myocardial work relationship. | yes |
18,559,303 | Are overweight HIV patients with abdominal fat distribution treated with protease inhibitors at high risk for abnormalities in glucose metabolism - a reason for glycemic control? | {
"contexts": [
"In HIV patients, disorders in glucose metabolism seem to be side effects of highly active antiretroviral therapy (HAART) which may be favoured by obesity, abdominal fat accumulation and familial disposition for diabetes mellitus (DM). The aim of our study was to identify patients at high risk for... | HIV patients on long-term PI therapy with overweight and familial disposition for DM are at high risk to develop abnormalities of glucose metabolism. Thus, measurements of HOMA-Index, BMI and waist circumference should be routinely done especially in PI medicated patients. | yes |
18,547,428 | Do an update on Uniform Resource Locator ( URL ) decay in MEDLINE abstracts and measures for its mitigation? | {
"contexts": [
"For years, Uniform Resource Locator (URL) decay or \"link rot\" has been a growing concern in the field of biomedical sciences. This paper addresses this issue by examining the status of the URLs published in MEDLINE abstracts, establishing current availability and estimating URL decay in these r... | URL persistence parallels previous studies which showed approximately 81% general availability during the 1-month study period. As peer-reviewed literature remains to be the main source of information in biomedicine, we need to ensure the accuracy and preservation of these links. | yes |
18,550,442 | Do pain catastrophizing and beliefs predict changes in pain interference and psychological functioning in persons with spinal cord injury? | {
"contexts": [
"The current study sought to examine how changes in pain-related beliefs and coping responses are related to changes in pain interference and psychological functioning in individuals with spinal cord injuries (SCI) and pain. To measure longitudinal changes in these variables, respondents completed... | Intervention studies targeting catastrophizing and maladaptive pain-related beliefs may be the next step in determining which variables play a causal role in the pain interference and psychological functioning of individuals with pain and SCI. | yes |
18,568,977 | Do an update of the general health status in the indigenous populations of Malaysia? | {
"contexts": [
"Health scenarios are constantly evolving, particularly in developing countries but little is known regarding the health status of indigenous groups in Malaysia. This study aims to elucidate the current health status in four indigenous populations in the country, who by and large been left out of ... | Our findings reflect a shifting health burden and an epidemiological transition, particularly in the Temuan and Bidayuh. These changes could be attributed to dietary habits, lifestyles and socio-economic factors brought about by urbanization. | yes |
18,565,266 | Does circulating survivin indicate severe course of juvenile idiopathic arthritis? | {
"contexts": [
"Survivin is an anti-apoptotic protein that has been recently suggested as a predictive marker of joint destruction in adult rheumatoid arthritis. We assessed the presence of extracellular survivin in patients with juvenile idiopathic arthritis (JIA).",
"Survivin levels were assessed in the ci... | Circulating survivin is expressed in a significant group of patients with JIA being associated to a severe course of the disease. It may be potentially used to select children with unfavorable prognosis of JIA who are in need of active pharmacologic treatment. | yes |
18,551,064 | Do donor postextubation hypotension and age correlate with outcome after donation after cardiac death transplantation? | {
"contexts": [
"Compared with standard donors, kidneys recovered from donors after cardiac death (DCD) exhibit higher rates of delayed graft function (DGF), and DCD livers demonstrate higher rates of biliary ischemia, graft loss, and worse patient survival. Current practice limits the use of these organs based o... | Time between profound instability and cold perfusion is a better predictor of outcome than time from extubation to asystole. If validated, this information could be used to predict DGF after DCD renal transplant and improve outcomes after DCD liver transplant. | yes |
18,546,285 | Does botulinum toxin type A induce direct analgesic effects in chronic neuropathic pain? | {
"contexts": [
"Botulinum toxin type A (BTX-A) has been reported to have analgesic effects independent of its action on muscle tone, possibly by acting on neurogenic inflammation. Such a mechanism may be involved in peripheral neuropathic pain.",
"A possible direct analgesic effect of BTX-A pain processing w... | These results indicate for the first time that BTX-A may induce direct analgesic effects in patients with chronic neuropathic pain independent of its effects on muscle tone and suggest novel indications for BTX-A in analgesia. | yes |
18,569,952 | Is paroxysmal atrial fibrillation uncommon in outpatients with chronic heart failure? | {
"contexts": [
"The objective was to evaluate the prevalence of paroxysmal atrial fibrillation (PAF) in patients with heart failure (HF) due to systolic dysfunction.",
"We included 79 patients (age 68 years, LVEF 30%) with HF and sinus-rhythm (SR) referred to a HF outpatient clinic. A 48 hours Holter ECG and... | Outpatients with HF due to systolic dysfunction did not present with PAF during 48 hours Holter, but had several episodes of AR. The clinical and prognostic importance of AR deserves further investigation. | yes |
18,557,008 | Do occupational therapy service use among people aging with multiple sclerosis? | {
"contexts": [
"We examined the use of occupational therapy services in a sample of people aging with multiple sclerosis (MS).",
"A total of 1,282 people with MS, ages 45 to 90, participated in telephone interviews to identify unmet health-related service needs. Occupational therapy was 1 of 22 services exam... | The results raise questions about what constitutes appropriate levels of occupational therapy service use and how to ensure that these levels are achieved. | yes |
18,557,007 | Do interrater reliability of Sensory Integration and Praxis Tests ( SIPT ) score interpretation? | {
"contexts": [
"This study examined interrater reliability of score interpretation on the Sensory Integration and Praxis Tests (SIPT).",
"Using SIPT scores of two complex cases, 20 trained participants independently rated each case for presence of sensory integrative dysfunction and for relevance of specific... | Interrater reliability was moderate to high for interpretation of the presence of sensory integrative dysfunction using SIPT scores. Less agreement was apparent regarding specific patterns of dysfunction. Results suggest that additional clinical information, such as clinical observations and case history, may be needed... | yes |
18,548,257 | Does the FVIIa-tissue factor complex induce the expression of MMP7 in LOVO cells in vitro? | {
"contexts": [
"The extracellular interactions of plasma clotting factor VIIa (FVIIa) with tissue factor (TF) on the cell surface trigger intracellular signaling events involved in multiple physiological processes. TF expression is related to the metastatic potential of tumor cells and is a significant risk fact... | Taken together, these data provide evidence that expression of MMP7 in colon cancer may be regulated by FVIIa and TF at the transcriptional level. MMP7 may act as a downstream mediator of FVIIa/TF signal transduction to facilitate the development of metastasis in colon cancer. | yes |
18,557,710 | Is childhood hygiene associated with the risk for inflammatory bowel disease : a population-based study? | {
"contexts": [
"The \"hygiene hypothesis\" postulates that individuals raised in a sanitary environment are more likely to develop inflammatory bowel disease (IBD). Several studies previously demonstrated contradictory results in this regard. We performed for the first time a population-based study on the associ... | Surrogate markers of childhood hygiene are associated with the risk for IBD, thus reinforcing the "hygiene hypothesis." | yes |
18,556,712 | Does absence of auto-antibodies against cardiac troponin I predict improvement of left ventricular function after acute myocardial infarction? | {
"contexts": [
"Application of antibodies against cardiac troponin I (cTnI-Ab) can induce dilation and dysfunction of the heart in mice. Recently, we demonstrated that immunization with cTnI induces inflammation and fibrosis in myocardium of mice. Others have shown that auto-antibodies to cTnI are present in pat... | We demonstrate for the first time that the prevalence of cTnI-Abs in patients with AMI has an impact on the improvement of the LVEF over a study period of 6-9 months. | yes |
18,560,942 | Do human breast tumor cells express multimodal imaging reporter genes? | {
"contexts": [
"Human ZR75-1 cells were among the first few characterized estrogen-dependent mammary gland carcinoma cell lines and had been utilized in various studies for the pro- or antitumor effect of xenoestrogens and antiestrogens. The objective of this study was to establish a breast tumor model in ZR75-1... | This study confirmed the usefulness of eGFP-tk in many applications by providing, in vitro and in vivo, the sensitive and reporter gene-specific imaging. ZR75-1-eGFP-tk cells that are ready to incorporate in various imaging platforms constitute a useful model in breast cancer research. | yes |
18,560,512 | Does the histidine kinase AHK5 integrate endogenous and environmental signals in Arabidopsis guard cells? | {
"contexts": [
"Stomatal guard cells monitor and respond to environmental and endogenous signals such that the stomatal aperture is continually optimised for water use efficiency. A key signalling molecule produced in guard cells in response to plant hormones, light, carbon dioxide and pathogen-derived signals i... | Our findings identify an integral signalling function for AHK5 that acts to integrate multiple signals via H(2)O(2) homeostasis and is independent of ABA signalling in guard cells. | yes |
18,557,987 | Do serum gastrin and pepsinogens correlate with the different grades of severity of gastro-oesophageal reflux disease : a matched case-control study? | {
"contexts": [
"Gastrin and pepsinogens reflect the functional state of the gastric mucosa.",
"To evaluate whether serum gastrin and pepsinogens correlate with the different grades of severity of gastro-oesophageal reflux disease (GERD).",
"In all, 388 patients with heartburn not taking any form of acid ... | Serum gastrin and pepsinogen I and II do not correlate with the different grades of severity of GERD. The non-invasive GastroPanel is not useful for the differentiation of the various forms of GERD. | no |
18,573,817 | Does memory decline evolve independently of disease activity in MS? | {
"contexts": [
"The natural history of cognitive impairment in multiple sclerosis (MS) and its relationship with disease activity is not well known. In this study, we evaluate a prospective cohort of 44 MS patients who were followed every 3 months for 2 years. Cognitive evaluation was done at baseline and by the... | Our findings indicate that verbal memory steadily declines in patients with MS from the beginning of the disease and independently of other parameters of disease activity. | yes |
18,547,972 | Is serum CA-125 level after 6 cycles of primary adjuvant chemotherapy a useful prognostic factor for complete responders ' survival in patients with advanced epithelial ovarian cancer? | {
"contexts": [
"The aim of this study was to evaluate the prognostic value of the serum CA-125 level for complete responders after 6 cycles of primary adjuvant paclitaxel/carboplatin chemotherapy in advanced epithelial ovarian cancer.",
"The clinical data of 123 complete responders after 6 cycles of primary ... | The serum CA-125 level after 6 cycles of primary adjuvant paclitaxel/carboplatin chemotherapy may be a good prognostic factor for survival in complete responders after 6 cycles of chemotherapy in advanced epithelial ovarian cancer. | yes |
18,544,997 | Does chemokine receptor CCR7 expression correlate with lymph node metastasis in pancreatic cancer? | {
"contexts": [
"The clinical significance of chemokine receptor CCR7 expression in pancreatic ductal cancer was investigated.",
"Immunohistochemical staining of 89 pancreatic cancers treated macroscopically with curative resection without hematogenous metastases or peritoneal dissemination were analyzed in a... | The survival impact of CCR7 expression on resectable pancreatic cancer may be associated with lymphatic spread. The results from the present study should foster further investigation of treatments using an inhibitor for the CCR7 protein to improve the survival of pancreatic cancer. | yes |
18,544,999 | Does xIAP-associated factor 1 ( XAF1 ) suppress angiogenesis in mouse endothelial cells? | {
"contexts": [
"XIAP-associated factor 1 (XAF1) is a tumor suppressor gene, but its role in angiogenesis is unknown. We investigated whether XAF1 has any antiangiogenesis effect.",
"MS1 (a mouse endothelial cell line) was infected with an adenoviral vector ZD55-XAF1. Controls were uninfected or infected with... | Our data suggest that XAF1 possesses a potential antiangiogenesis effect. Suppressed expression of Tie-1, Ang-1, Ang-2 and c-Myc may be mechanistically responsible for the observed antiangiogenesis effect. | yes |
18,573,415 | Does age at repair affect the very long-term outcome of sinus venosus defect? | {
"contexts": [
"Records of patients who had repair of sinus venosus defect (SVD) between 1970 and 2008 were reviewed to predict very long-term outcome.",
"Repairs occurred in 104 consecutive patients (51 men), aged 29 +/- 23 years (range, 1 to 70 years). Seven had isolated SVD and 97 had associated lesions t... | SVD repair at an older age is associated with increased risk of late mortality, adverse cardiac events, and worse functional outcome. Repair during childhood is strongly advised. | yes |
18,560,789 | Is dietary magnesium intake related to metabolic syndrome in older Americans? | {
"contexts": [
"Magnesium (Mg) is an essential cofactor for enzymes involved in glucose and insulin metabolism. Low intakes of dietary magnesium may be linked to greater risk of metabolic syndrome (MS) in older adults.",
"The objective of this study was to examine the cross-sectional relationship between die... | Our study demonstrates that Mg intake is inversely associated with prevalence of the MS in older adults. Older adults should be encouraged to eat foods rich in Mg, such as green vegetables, legumes and whole-grains. | yes |
18,560,516 | Does cellular islet autoimmunity associate with clinical outcome of islet cell transplantation? | {
"contexts": [
"Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin-independent in the following years. We tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to this progressive loss of islet allograft function.",
"Twe... | In this cohort study, cellular islet-specific autoimmunity associates with clinical outcome of islet cell transplantation under ATG-tacrolimus-MMF immunosuppression. Tailored immunotherapy targeting cellular islet autoreactivity may be required. Monitoring cellular immune reactivity can be useful to identify factors in... | yes |
18,565,131 | Does thrombin induce osteoprotegerin synthesis via phosphatidylinositol 3'-kinase/mammalian target of rapamycin pathway in human periodontal ligament cells? | {
"contexts": [
"Thrombin influences the biological behavior of periodontal ligament cells and plays multiple roles in the early stages of bone healing. Osteoprotegerin (OPG) is one of the key molecules that regulate bone homeostasis and prevent osteoclastogenesis. The purpose of this study was to evaluate the bi... | Thrombin induces OPG synthesis in HPDL cells post-transcriptionally, possibly through PAR-1. The regulation was through the PI3K/Akt and mTOR pathway. This finding suggests that thrombin may play a significant role in alveolar bone repair and homeostasis of periodontal tissue, partly through the OPG/RANKL system. | yes |
18,554,398 | Does whole genome assessment of the retinal response to diabetes reveal a progressive neurovascular inflammatory response? | {
"contexts": [
"Despite advances in the understanding of diabetic retinopathy, the nature and time course of molecular changes in the retina with diabetes are incompletely described. This study characterized the functional and molecular phenotype of the retina with increasing durations of diabetes.",
"Using ... | These changes in permeability, apoptosis, and gene expression provide further evidence of progressive retinal malfunction with increasing duration of diabetes. The specific gene expression changes confirmed in multiple sets of animals indicate that pro-inflammatory, anti-vascular barrier, and neurodegenerative changes ... | yes |
18,558,872 | Does a luciferase immunoprecipitation systems assay enhance the sensitivity and specificity of diagnosis of Strongyloides stercoralis infection? | {
"contexts": [
"We investigated whether luciferase immunoprecipitation systems (LIPS) can be the basis for a more rapid, specific, and standardized assay for the diagnosis of Strongyloides stercoralis infection.",
"A LIPS assay was developed based on immunoglobulin (Ig) G or IgG4 antibody to a recombinant St... | LIPS addresses several limitations of current ELISAs and represents a major advance in the diagnosis of S. stercoralis infection. | yes |
18,551,513 | Do de novo LMNA mutations cause a new form of congenital muscular dystrophy? | {
"contexts": [
"To describe a new entity of congenital muscular dystrophies caused by de novo LMNA mutations.",
"Fifteen patients presenting with a myopathy of onset in the first year of life were subjected to neurological and genetic evaluation. Histopathological and immunohistochemical analyses were perfor... | The LMNA mutations identified appear to correlate with a relatively severe phenotype. Our results further broaden the spectrum of laminopathies and define a new disease entity that we suggest is best classified as a congenital muscular dystrophy (LMNA-related congenital muscular dystrophy, or L-CMD). | yes |
18,569,226 | Does response to bronchodilators after exercise challenge predict bronchial hyperreactivity? | {
"contexts": [
"Some subjects with suspected asthma and a negative exercise challenge test (ECT) demonstrate improved expiratory flow rates after administration of bronchodilators (BD) at the end of the ECT (unpublished observation). This study investigated whether this response predicts the presence of bronchia... | BD should be administered routinely after ECT, as the response may be used as a simple, inexpensive tool to predict BHR in young patients and may substantially reduce the number of unnecessary MCTs. | yes |
18,544,941 | Is hepatitis B core-related antigen assay useful for monitoring the antiviral effects of nucleoside analogue therapy? | {
"contexts": [
"The clinical significance of the hepatitis B virus core-related antigen (HBcrAg) assay in monitoring the antiviral effects of lamivudine is reviewed.",
"The HBcrAg assay simultaneously measured serum levels of hepatitis B core (HBc) and e (HBe) antigens using monoclonal antibodies which recog... | The HBcrAg assay is indeed useful for monitoring the antiviral effects of lamivudine, and we propose that it be adopted as a serum marker which reflects the amount of HBV covalently closed circular DNA in hepatocytes. | yes |
18,544,076 | Is uVA1 phototherapy effective in darker skin : a review of 101 patients of Fitzpatrick skin types I-V? | {
"contexts": [
"Studies suggest ultraviolet (UV) A1 phototherapy is efficacious and safe in treating a variety of skin disorders. However, most reports evaluating the benefits of UVA1 phototherapy have been from Europe, focusing on a predominantly Caucasian population. Darker skin types have been evaluated only ... | Data indicate skin pigmentation as graded by Fitzpatrick skin type does not significantly influence the efficacy of UVA1 phototherapy. Thus, UVA1 should be considered as a therapeutic option in more darkly pigmented patients. | yes |
18,544,467 | Is husbands ' SUD associated with higher levels of co-occurring but not non-co-occurring psychiatric disorders among their wives? | {
"contexts": [
"Substance use among husbands has been shown to be associated with higher rates of substance use and of psychiatric symptoms among their wives. However, substance use disorders (SUD) and psychiatric disorders (as opposed to substance use or psychiatric symptoms) are rarely rigorously assessed amon... | These findings demonstrate that SUD and co-occurring psychiatric disorders (with SUD) are more common among the spouses of SUD+ husbands than among the spouses of SUD- husbands, but non-co-occurring ("pure") psychiatric disorders are not more common among the spouses of the SUD+ husbands. | yes |
18,555,231 | Do submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity? | {
"contexts": [
"To evaluate the effect of uterine leiomyomas on the endometrium using molecular markers of endometrial receptivity: HOXA10, HOXA11, LIF, and BTEB1.",
"Case-control study.",
"University medical center.",
"Thirty reproductive-aged women with submucosal, intramural, or no uterine myomas ... | The molecular mechanism by which submucosal myomas adversely affect reproduction includes a global decrease in endometrial HOX gene expression, not simply a focal change over the myoma. This may explain the reproductive dysfunction observed with submucosal myomas. | yes |
18,555,233 | Is sperm head morphology related to high deoxyribonucleic acid stainability assessed by sperm chromatin structure assay? | {
"contexts": [
"To examine the relationship between sperm strict morphology and sperm chromatin integrity.",
"Prospective study.",
"Infertility clinic.",
"Eighty-seven consecutive semen samples from non-azoospermic men presenting for infertility evaluation and 6 samples from fertile donors.",
"As... | The observed relationship between sperm head defects and %HDS suggests that sperm head abnormalities may, in part, be due to incomplete sperm chromatin condensation. | yes |
18,547,571 | Does eUS accurately predict the need for therapeutic ERCP in patients with a low probability of biliary obstruction? | {
"contexts": [
"Because of its inherent risks, ERCP should only be performed for purposes of treatment. EUS and MRCP have emerged as diagnostic alternatives before therapeutic ERCP.",
"Our purpose was to test the accuracy of EUS in predicting the need for therapeutic ERCP in low-risk patients.",
"Prospec... | Single-center experience. | yes |
18,551,126 | Is overweight associated with decreased cognitive functioning among school-age children and adolescents? | {
"contexts": [
"Childhood overweight and obesity have increased substantially in the past two decades, raising concerns about their psychosocial and cognitive consequences. We examined the associations between academic performance (AP), cognitive functioning (CF), and increased BMI in a nationally representative... | Increased body weight is independently associated with decreased visuospatial organization and general mental ability among children. Future research is needed to determine the nature, persistence, and functional significance of this association. | yes |
18,545,701 | Is tDP-43 a common cause of sporadic amyotrophic lateral sclerosis? | {
"contexts": [
"TAR DNA binding protein, encoded by TARDBP, was shown to be a central component of ubiquitin-positive, tau-negative inclusions in frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Recently, mutations in TARDBP have been linked to familial and sporadic ALS.",
... | Our data indicate that genetic variation in TARDBP is not a common cause of sporadic ALS in North American. | no |
18,545,705 | Do allogeneic lymphocytes persist and traffic in feral MHC-matched mauritian cynomolgus macaques? | {
"contexts": [
"Thus far, live attenuated SIV has been the most successful method for vaccinating macaques against pathogenic SIV challenge; however, it is not clear what mechanisms are responsible for this protection. Adoptive transfer studies in mice have been integral to understanding live attenuated vaccine ... | MHC-matched MCM provide the first viable primate model for adoptive transfer studies. Because macaques infected with SIV are the best model for HIV/AIDS pathogenesis, we can now directly study the correlates of protective immune responses to AIDS viruses. For example, plasma viral loads following pathogenic SIV challen... | yes |
7,478,830 | Does a pacifier increase the risk of recurrent acute otitis media in children in day care centers? | {
"contexts": [
"To follow up a previous retrospective analysis in which we found the use of a pacifier to be a risk factor for recurrent acute otitis media (AOM).",
"In the present prospective study, the occurrence of AOM and the use of a pacifier were recorded in 845 children attending day care centers duri... | We conclude that the use of a pacifier is a significant risk factor for recurrent AOM and suggest that pacifiers should be used only during the first 10 months of life, when need for sucking is strongest, and AOM is uncommon. | yes |
7,478,835 | Does elevated serum lactate correlate with intracranial hemorrhage in neonates treated with extracorporeal life support? | {
"contexts": [
"To correlate the initial and maximal lactate levels with the occurrence of intracranial hemorrhage (ICH) and survival in patients treated with extracorporeal life support (ECLS).",
"Retrospective chart review.",
"Pediatric intensive care unit.",
"Eighty-two neonatal patients placed on... | Lactate is a useful marker for the development of ICH in ECLS patients. In addition, elevated lactates during ECLS identify a subgroup of patients with poor outcome. Prospective studies are needed to determine whether the incorporation of this information into pre-ECLS and ECLS management will decrease the occurrence o... | yes |
7,492,256 | Do signs of defensive control locate conflicted topics in discourse? | {
"contexts": [
"Psychodynamic clinicians cite defensive actions observed in evaluation and treatment as a source of important information. Empirical support for such assertions has seldom been based on objective study of recorded psychotherapy. A quantitative study of the association of signs of defensive contro... | The findings support the psychodynamic hypothesis that observation of defensive behaviors may locate times of communication about conflicted themes. | yes |
7,495,350 | Does maternal age influence risk for HLA-B27 associated ankylosing enthesopathy in transgenic mice? | {
"contexts": [
"To study further the temporal clustering of ankylosing enthesopathy (AE) noted originally during a study of the influence of mouse major histocompatibility complex (MHC) H-2 and transgenic HLA-B27 on the frequency of AE.",
"The relationship between maternal age at littering and frequency of A... | Maternal age is a novel, non-genetic risk factor as defined in relation to an MHC associated enthesopathy. Its mode of action and relevance to human disease require further investigation. | yes |
7,491,661 | Does nonocclusive common carotid artery thrombosis in the rat result in reversible sensorimotor and cognitive behavioral deficits? | {
"contexts": [
"Microemboli released during transient ischemic attack, stroke, and cardiac surgery are thought to cause a variety of functional deficits in humans. The purpose of this study was to characterize the type and extent of neurobehavioral deficits present after photochemically induced common carotid ar... | CCAT produces consistent sensorimotor and cognitive behavioral deficits that recover within 2 weeks of injury. Behavioral outcome was not necessarily associated with overt histopathological damage, suggesting that reversible injury mechanisms, both vascular and neuronal, may be partly responsible for the temporary loss... | yes |
7,494,349 | Is limited range of motion a significant factor in venous ulceration? | {
"contexts": [
"Calf muscle pump dysfunction is a recognized factor in chronic venous insufficiency (CVI). We investigated the hypothesis that limbs with CVI have a reduced ankle range of motion (ROM) that may be responsible for the poor calf pump function associated with venous ulceration.",
"Ankle ROM and ... | Limbs with CVI have a limited ankle ROM that decreases with increasing severity of clinical symptoms. This decreased ROM is associated with, and may contribute to, poor calf pump function. | yes |
7,477,492 | Does [ Good surgery result in older patients with stage 1 lung carcinoma ]? | {
"contexts": [
"To determine the influence of age on survival of patients undergoing resection for lung cancer.",
"Retrospective.",
"South-western part of the Netherlands.",
"Follow-up information was gathered on patients who had undergone resection for stage I non-small cell lung cancer from 1984 th... | Chronological age has a limited influence on the survival of patients with lung cancer and does not preclude surgical treatment. | yes |
7,486,155 | Does intrathecal amitriptyline act as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats? | {
"contexts": [
"Amitriptyline and other tricyclic antidepressants exhibit high affinity binding to N-methyl-D-aspartate (NMDA) receptors in vitro and inhibit NMDA receptor activation-induced neuroplasticity in hippocampal slices. Because spinal NMDA receptor activation is believed to be central to generation and... | Amitriptyline and other tricyclic antidepressants have been demonstrated to exhibit modest activity against clinical neuropathic pain after systemic administration. These data suggest that more profound pain relief might be obtained by intrathecal administration. Amitriptyline reverses hyperalgesia in rats by a mechani... | yes |
7,486,157 | Does one-day hypothermic preservation of isolated hearts with halothane improve cardiac function better than low calcium? | {
"contexts": [
"Halothane exerts a potent negative inotropic effect on the heart and mimics many of the cardiac effects of lowered extracellular CaCl2. Reduced slow inward Ca2+ current and sarcoplasmic reticular effects on intracellular Ca2+ are likely involved. The authors reported previously that halothane pro... | Halothane administered during hypothermia restores left ventricular pressure, cardiac efficiency, basal coronary flow, and flow responses better than low CaCl2. Although halothane and low CaCl2 both reduce intracellular Ca2+, contractile force, and metabolic demand, the better protective effect of halothane is not like... | yes |
7,486,153 | Do desflurane and isoflurane exert modest beneficial actions on left ventricular diastolic function during myocardial ischemia in dogs? | {
"contexts": [
"Volatile anesthetics exert cardioprotective effects during myocardial ischemia. This investigation examined the regional systolic and diastolic mechanical responses to brief left anterior descending coronary artery (LAD) occlusion in the central ischemic zone and in remote normal myocardium in th... | The results indicate that increases in contractility of remote myocardium during brief regional ischemia were preserved in the presence of desflurane and isoflurane anesthesia. In addition, desflurane and isoflurane blunted ischemia-induced increases in tau and regional chamber stiffness in both the ischemic and nonisc... | yes |
7,487,689 | Is serum 25-hydroxyvitamin D3 related to physical activity and ethnicity but not obesity in a multicultural workforce? | {
"contexts": [
"Recent research suggests that body vitamin D levels are decreased in coronary heart disease and diabetes, but it is unclear which cardiovascular risk factors are related to vitamin D status.",
"To examine the relation between vitamin D status and major cardiovascular risk factors.",
"Seru... | People with increased skin pigmentation, such as Polynesians, and people who are inactive, have decreased body levels of vitamin D; this might partly explain their increased risk of cardiovascular disease. | yes |
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