pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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|---|---|---|---|---|
26,528,065 | Is combined glutathione S transferase M1/T1 null genotypes associated with type 2 diabetes mellitus? | {
"contexts": [
"Due to new genetic insights, a considerably large number of genes and polymorphic gene variants are screened and linked with the complex pathogenesis of type 2 diabetes (DM). Our study aimed to investigate the association between the two isoforms of the glutathione S-transferase genes (Glutathion... | The main finding of our study is that the combined, double GSTM1/GSTT1 null genotypes are to be considered among the polymorphic genetic risk factors for type 2 DM. | yes |
26,551,442 | Is vigorous exercise associated with superior metabolic profiles in polycystic ovary syndrome independent of total exercise expenditure? | {
"contexts": [
"To characterize metabolic features of women with polycystic ovary syndrome (PCOS) by exercise behavior and determine relative health benefits of different exercise intensities.",
"Cross-sectional study.",
"Tertiary academic institution.",
"Three hundred and twenty-six women aged 14-52... | Women with PCOS who met DHHS guidelines for exercise demonstrated superior metabolic health parameters. Vigorous but not moderate activity is associated with reduced odds of the metabolic syndrome, independent of age, BMI, and total energy expenditure. PCOS patients should be encouraged to meet activity guidelines via ... | yes |
26,546,362 | Do glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity? | {
"contexts": [
"HIV-1-infected and/or immune-activated microglia and macrophages are pivotal in the pathogenesis of HIV-1-associated neurocognitive disorders (HAND). Glutaminase, a metabolic enzyme that facilitates glutamate generation, is upregulated and may play a pathogenic role in HAND. Our previous studies ... | These findings support MVs as a potential pathway/mechanism of excessive glutamate generation and neurotoxicity in HAND and therefore MVs may serve as a novel therapeutic target. | yes |
26,531,321 | Do fasting hyperinsulinaemia and 2-h glycaemia predict coronary heart disease in patients with type 2 diabetes? | {
"contexts": [
"Patients with diabetes are at greater risk of cardiovascular events. Insulin resistance (IR) and hyperinsulinaemia are both related to an increased cardiovascular risk, but whether IR predicts coronary heart disease (CHD) independently of other risk factors in patients with type 2 diabetes (T2D) ... | Fasting insulin levels are positively associated with incidence of CHD in T2D. Furthermore, 2hPG appears to be a significant predictor of incident CHD independently of other risk factors, including HbA1c. These findings suggest that strategies targeting the reduction of insulinaemia and post-load glycaemia may be usefu... | yes |
26,548,998 | Is mechanical stress associated with right ventricular response to pulmonary valve replacement in patients with repaired tetralogy of Fallot? | {
"contexts": [
"Patients with repaired tetralogy of Fallot account for a substantial proportion of cases with late-onset right ventricular failure. The current surgical approach, which includes pulmonary valve replacement/insertion, has yielded mixed results. Therefore, it may be clinically useful to identify pa... | Computational modeling and right ventricular stress may be used as tools to identify right ventricular function response to pulmonary valve replacement. Large-scale clinical studies are needed to validate these preliminary findings. | yes |
26,529,046 | Do nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice? | {
"contexts": [
"To evaluate the efficacy of nucleoside reverse transcriptase inhibitors (NRTIs) in the laser-induced mouse model of choroidal neovascularization (CNV).",
"We evaluated the NRTIs lamivudine (3TC), zidovudine (AZT), and abacavir (ABC) and the P2X7 antagonist A438079. Choroidal neovascularizatio... | Multiple clinically relevant NRTIs suppressed laser-induced CNV and downregulated VEGF-A, via P2X7. | yes |
26,553,429 | Is obesity associated with increased postoperative complications after operative management of tibial shaft fractures? | {
"contexts": [
"To assess the association of obesity and postoperative complications after operative management of tibial shaft fractures.",
"Patients who underwent operative management of a tibial shaft fracture were identified in a national database by Current Procedural Terminology (CPT) codes for: (1) op... | In patients who undergo either ORIF or IMN for tibial shaft fractures, obesity and its related medical comorbidities are associated with significantly increased rates of postoperative medical complications, infection, nonunion, and implant removal compared to non-obese patients. | yes |
26,542,235 | Does mR Elastography demonstrate Increased Brain Stiffness in Normal Pressure Hydrocephalus? | {
"contexts": [
"Normal pressure hydrocephalus is a reversible neurologic disorder characterized by a triad of cognitive impairment, gait abnormality, and urinary incontinence that is commonly treated with ventriculoperitoneal shunt placement. However, multiple overlapping symptoms often make it difficult to diff... | This study demonstrates increased brain stiffness in patients with normal pressure hydrocephalus compared with age- and sex-matched healthy controls; these findings should motivate future studies investigating the use of MR elastography for this condition and the efficacy of shunt therapy. | yes |
26,553,403 | Are copper surfaces associated with significantly lower concentrations of bacteria on selected surfaces within a pediatric intensive care unit? | {
"contexts": [
"Health care-associated infections result in significant patient morbidity and mortality. Although cleaning can remove pathogens present on hospital surfaces, those surfaces may be inadequately cleaned or recontaminated within minutes. Because of copper's inherent and continuous antimicrobial prop... | Copper surfaces warrant serious consideration when contemplating the introduction of no-touch disinfection technologies for reducing burden to limit acquisition of HAIs. | yes |
26,546,586 | Does increased pretreatment serum IFN-β/α ratio predict non-response to tumour necrosis factor α inhibition in rheumatoid arthritis? | {
"contexts": [
"Studies suggest that circulating type I interferon (IFN) may predict response to biological agents in rheumatoid arthritis (RA). Prediction of response prior to initiating therapy would represent a major advancement.",
"We studied sera from a test set of 32 patients with RA from the Auto-immu... | Increased pretreatment serum IFN-β/α ratio strongly associated with non-response to TNF inhibition. This study supports further investigation of serum type I IFN in predicting outcome of TNF inhibition in RA. | yes |
26,540,171 | Is degree of Rectal Distension Seen on Prostate Radiotherapy Planning CT Scan a Negative Prognostic Factor in the Modern Era of Image-Guided Radiotherapy? | {
"contexts": [
"Studies have shown that rectal distension has a significant impact on treatment failure in patients receiving radical radiotherapy for prostate cancer. A distended rectum contributes to excessive organ movement during treatment, resulting in significant underdosing of the target volume and higher... | In this cohort of predominately high-risk localised prostate cancer, rectal distension had no significant impact on PSA relapse. We suggest that regular imaging during radiotherapy negates the risk caused by rectal distension on local treatment failure. | no |
26,538,180 | Does boron-deficiency-responsive microRNAs and their targets in Citrus sinensis leave? | {
"contexts": [
"MicroRNAs play important roles in the adaptive responses of plants to nutrient deficiencies. Most research, however, has focused on nitrogen (N), phosphorus (P), sulfur (S), copper (Cu) and iron (Fe) deficiencies, limited data are available on the differential expression of miRNAs and their targe... | Our study reveals some novel responses of citrus to B-deficiency, which increase our understanding of the adaptive mechanisms of citrus to B-deficiency at the miRNA (post-transcriptional) level. | yes |
26,554,648 | Is overexpression of major CDKN3 transcripts associated with poor survival in lung adenocarcinoma? | {
"contexts": [
"The cyclin-dependent kinase inhibitor 3 (CDKN3) has been perceived as a tumour suppressor. Paradoxically, CDKN3 is often overexpressed in human cancer. It was unclear if CDKN3 overexpression is linked to alternative splicing variants or mutations that produce dominant-negative CDKN3.",
"We an... | CDKN3 overexpression is prognostic of poor overall survival in lung adenocarcinoma. CDKN3 overexpression in lung adenocarcinoma is not attributed to alternative splicing or mutation but is likely due to increased mitotic activity, arguing against CDKN3 as a tumour suppressor. | yes |
26,551,585 | Does fGFR4 be a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma? | {
"contexts": [
"The aim of this study was to investigate whether fibroblast growth factor receptor 4 (FGFR4) could serve as a potential therapeutic target, prognostic biomarker or biomarker predicting radiotherapy sensitivity in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC... | FGFR4 is frequently overexpressed in OSCC and OPSCC in the absence of gene amplification, and may serve as a potential predictive marker for FGFR4-directed targeted therapy in OSCC and OPSCC. | yes |
26,524,959 | Do baseline cerebral oximetry values depend on non-modifiable patient characteristics? | {
"contexts": [
"The aim of the present study was to evaluate baseline regional cerebral oxygen saturation (rSO2) values and identify factors influencing preoperative rSO2 in elective minor surgery.",
"Observational analysis post-hoc.",
"Observational post-hoc analysis of data for the patient sample (n=50... | Non-modifiable patient characteristics (ASA physical status, sex, chronic renal failure, body weight and height) influence baseline rSO2. | yes |
26,525,607 | Is global DNA hypomethylation associated with the development and poor prognosis of tongue squamous cell carcinoma? | {
"contexts": [
"Oral cancer is the 4th leading cause of cancer death for males and the top cancer in young adult males in Taiwan. Tongue squamous cell carcinoma (TSCC) is a common oral cancer and generally associated with poor prognosis. Global DNA hypomethylation at the 5 position of cytosine (5mC) is a well-kn... | Global hypomethylation was an independent biomarker for the development and poor prognosis of TSCC. | yes |
26,542,848 | Do postzygotic barriers isolate sympatric species of Cyrtandra ( Gesneriaceae ) in Hawaiian montane forest understories? | {
"contexts": [
"Recent reviews of reproductive isolation (RI) in plants propose that boundaries between closely related species are maintained predominantly through prezygotic mechanisms. However, few experimental studies have explored how boundaries are maintained in long-lived species. Hawaiian Cyrtandra prese... | Results suggest that boundaries between sympatric Cyrtandra species in Hawaii are maintained predominantly through postzygotic barriers. Observations from between-island crosses indicate that postzygotic barriers can arise in allopatry, which may be important in the initial divergence of populations. Future studies of ... | yes |
26,542,842 | Is selection on pollen and pistil traits during pollen competition affected by both sexual conflict and mixed mating in a self-compatible herb? | {
"contexts": [
"Although much attention has focused on the diversity of plant mating systems, only a few studies have considered the joint effects of mating system and sexual conflict in plant evolution. In mixed-mating Collinsia heterophylla, a sexual conflict over timing of stigma receptivity is proposed: poll... | Selection on pollen and pistil traits in C. heterophylla is affected by both sexual conflict and mixed mating, suggesting the importance of jointly considering these factors in plant evolution. | yes |
26,550,029 | Does identification of structural alert for liver and kidney toxicity using repeated dose toxicity data? | {
"contexts": [
"The potential for a compound to cause hepatotoxicity and nephrotoxicity is a matter of extreme interest for human health risk assessment. To assess liver and kidney toxicity, repeated-dose toxicity (RDT) studies are conducted mainly on rodents. However, these tests are expensive, time-consuming a... | It was not possible to assign an unambiguous mode of action for all the SAs, but a mechanistic explanation is provided for some of them. Such achievements may help in the early identification of liver and renal toxicity of substances. | yes |
26,544,874 | Does cytochrome P450 Oxidoreductase influence CYP2B6 Activity in Cyclophosphamide Bioactivation? | {
"contexts": [
"Cyclophosphamide is commonly used as an important component in conditioning prior to hematopoietic stem cell transplantation, a curative treatment for several hematological diseases. Cyclophosphamide is a prodrug activated mainly by cytochrome P450 2B6 (CYP2B6) in the liver. A high degree of inte... | This investigation shows for the first time that POR besides CYP2B6 can influence cyclophosphamide metabolism. Our results indicate that not only CYPs are important, but also POR expression and/or activity may influence cyclophosphamide bioactivation, affecting therapeutic efficacy and treatment related toxicity and he... | yes |
26,526,196 | Does targeting glycolysis by 3-bromopyruvate improve tamoxifen cytotoxicity of breast cancer cell lines? | {
"contexts": [
"Tamoxifen is the standard endocrine therapy for ER+ breast cancer; however, many women still relapse after long-term therapy. 3-Bromopyruvate, a glycolytic inhibitor, has shown high selective anti-tumor activity in vitro, and in vivo. The aim of this study was to evaluate the possible augmentatio... | 3-bromopyruvate could be a valuable compound when added with tamoxifen in breast cancer treatment. | yes |
26,554,243 | Does lipopolysaccharide enhance Beta2-Glycoprotein I Activation of Nuclear Factor κB in Liver Cancer Cells? | {
"contexts": [
"Beta2-glycoprotein I (β2GPI) is a highly abundant glycoprotein in plasma. Our previous study demonstrated strong β2GPI expression in hepatitis B-related hepatocellular carcinoma (HCC) tissue and the combination of β2GPI and hepatitis B surface antigen (HBsAg) was shown to significantly activate t... | LPS enhanced the signal transduction of β2GPI in liver cancer cells leading to activation of NF-κB, which triggered downstream signal transduction and increased the expression of downstream factors. This suggests that LPS enhancement of β2GPI signal transduction may play a role in promoting the development of liver can... | yes |
26,554,245 | Is photodynamic Therapy-Induced Apoptosis of Keloid Fibroblasts Mediated by Radical Oxygen Species In Vitro? | {
"contexts": [
"It has been demonstrated that photodynamic therapy (PDT) is a promising treatment approach for hyperplastic dermatosis and results in a beneficial outcome. In the present study, PDT involving hematoporphyrin monomethyl ether (HMME) was applied to keloid fibroblasts (KFB), and the effects and the ... | Our data indicated that HMME-mediated PDT could inhibit keloid fibroblast proliferation and could also induce apoptosis. This process was associated with the production of ROS. | yes |
26,554,247 | Is increased Neutrophil to Lymphocyte Ratio Associated with In-Hospital Mortality in Patients with Aortic Dissection? | {
"contexts": [
"i ne prognostic relevance of hematological parameters in cardiovascular diseases has been well demonstrated. The purpose of the present study is to investigate the association between the hematological parameters, particularly neutrophil to lymphocyte ratio (NLR), and outcomes of aortic dissectio... | In patients with AD, NLR levels were increased compared to patients with AAD and controls and were independently associated with in-hospital mortality. This finding implicates that admission hematological parameters may have clinical importance in evaluating the mortality risk in patients with AD. | yes |
26,540,915 | Do [ The sequencing analyze of 915 newborn with GJB2 heterozygous mutation in Beijing ]? | {
"contexts": [
"To determine GJB2 allelic mutant and estimate probability of hereditary hearing loss in newborn with GJB2 heterozygous mutation in Beijing.",
"We performed genetic testing for sequencing of GJB2 gene for searching GJB2 allelic mutant in 915 newborn who received newborn deafness gene screening... | The probability of hereditary hearing loss is 7.09% in newborn with GJB2 heterozygous mutation in Beijing. It is noteworthy that c. 109G>A, c. 368C>A occupy a high proportion. | yes |
26,527,560 | Do obese patients have similar short-term outcomes to non-obese in laparoscopic colorectal surgery? | {
"contexts": [
"To determine whether obese patients undergoing laparoscopic surgery within an enhanced recovery program had worse short-term outcomes.",
"A prospective study of consecutive patients undergoing laparoscopic colorectal resection was carried out between 2008 and 2011 in a single institution. Pat... | Obesity (BMI > 25) does not lead to worse short-term outcomes in laparoscopic colorectal surgery and therefore such patients should not be precluded from laparoscopic surgery. | yes |
26,524,703 | Is moderate Alcohol Consumption Associated with Reduced All-cause Mortality? | {
"contexts": [
"A large body of research suggests that light or moderate alcohol consumption is associated with reduced all-cause mortality. However, concerns remain that the observed relationship is due to selection bias, misclassification of ex-drinkers, or residual confounding.",
"The association between ... | Moderate alcohol consumption is not associated with reduced all-cause mortality in older adults. The previously observed association may have been due to residual confounding. | no |
26,528,354 | Do polyunsaturated fatty acids trigger apoptosis of colon cancer cells through a mitochondrial pathway? | {
"contexts": [
"Colorectal cancer is common in developed countries. Polyunsaturated fatty acids (PUFAs) have been reported to possess tumoricidal action, but the exact mechanism of their action is not clear.",
"In the present study, we studied the effect of various n-6 and n-3 fatty acids on the survival of ... | PUFAs induced apoptosis of colon cancer cells through a mitochondrial dependent pathway. | yes |
26,528,359 | Is melatonin more effective than ascorbic acid and β-carotene in improvement of gastric mucosal damage induced by intensive stress? | {
"contexts": [
"Oxidative stress has been considered to play a primary role in the pathogenesis of stress-induced gastric damage. The aim of this study was to investigate the effects of melatonin, ascorbic acid and β-carotene on stress-induced gastric mucosal damage.",
"Fifty-six male Wistar albino rats were... | Melatonin is more effective than ascorbic acid and β-carotene in improvement of gastric damage induced by intensive stress. We suggest that as well as the direct antioxidant and free radical scavenging potency of melatonin, its indirect effect via the brain-gut axis might account for its greater beneficial action again... | yes |
26,530,319 | Are signs of immune activation and local inflammation present in the bronchial tissue of patients with untreated early rheumatoid arthritis? | {
"contexts": [
"Events in the lungs might contribute to generation of anticitrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA). We investigated if signs of immune activation are present in bronchial biopsies and bronchoalveolar lavage (BAL) of patients with early-untreated RA without clinical sig... | Signs of immune cell accumulation and activation are present both in the bronchial tissue and in BAL of untreated patients with early RA without concomitant lung disease, strengthening the role of the lung compartment as an important player in ACPA-positive RA. | yes |
26,544,611 | Is cannabis use disorder associated with greater illness severity in tobacco smoking patients with bipolar disorder? | {
"contexts": [
"Cannabis use disorders (CUD) may influence the course of bipolar disorder (BD), but key confounding factors such as tobacco smoking have not been adequately addressed. This study examined whether CUD was associated with a more severe illness course in tobacco smoking BD patients.",
"A sample ... | Despite the multivariate approach, differences between the two samples may lead to spurious findings related to hidden confounders. Substance use and mood episode information was collected retrospectively, and potential birth cohort effects could not be controlled for. | yes |
26,549,599 | Is anxiety associated with increased risk of dementia in older Swedish twins? | {
"contexts": [
"We asked whether anxiety is associated with prospective risk of dementia, and the extent to which genetic influences mediate this association.",
"Nondemented twins (n = 1082) from the Swedish Adoption Twin Study of Aging completed an assessment of anxiety symptoms in 1984 and were followed fo... | Anxiety symptoms were associated with increased risk of dementia. Genetic factors common to dementia and anxiety partially mediated this association. | yes |
26,542,776 | Are excessive reactive oxygen species therapeutic targets for intervertebral disc degeneration? | {
"contexts": [
"Oxidative stress has been reported to be involved in numerous human diseases, including musculoskeletal disorders such as osteoarthritis. However, the interaction between intervertebral disc (IVD) degeneration and oxidative stress is not well understood. The purpose of the present study was to el... | A positive feedback loop was formed between excessive ROS and TNF-alpha in AF cells. Thus, oxidative stress contributes to the progression of IVD degeneration and NAC can be a therapeutic option for IVD degeneration. | yes |
26,545,364 | Is overexpression of the long non-coding RNA PVT1 correlated with leukemic cell proliferation in acute promyelocytic leukemia? | {
"contexts": [
"Acute promyelocytic leukemia (APL) is associated with chromosomal translocation t(15;17), which results in the proliferation of morphologically abnormal promyelocytes. Gain of supernumerary copies of the 8q24 chromosomal region, which harbors MYC and PVT1, has been shown to be the most common sec... | Our findings reveal that the lncRNA PVT1 may play an important role in the proliferation of APL cells and may be useful for future therapeutic management. | yes |
26,550,120 | Does angiogenesis and proliferation of bile duct enhance ischemic tolerance in rats with cirrhosis? | {
"contexts": [
"Primary biliary cirrhosis (PBC), an autoimmune disease of the liver, is marked by slow progressive destruction of bile ducts. These patients with PBC often undergo orthotopic liver transplantation (OLT). Ischemic bile duct lesion (IBDL) is a major source of morbidity and even mortality after OLT.... | The results suggest that a liver with cirrhosis has a better ischemic tolerance than a normal liver. Angiogenesis and proliferation of bile duct enhances ischemic tolerance in rats with cirrhosis. More research on the pathogenesis of IBDLs is needed for developing more specific preventive or therapeutic strategies. | yes |
26,541,582 | Does sevoflurane postconditioning improve long-term learning and memory of neonatal hypoxia-ischemia brain damage rats via the PI3K/Akt-mPTP pathway? | {
"contexts": [
"Volatile anesthetic postconditioning has been documented to provide neuroprotection in adult animals. Our aim was to investigate whether sevoflurane postconditioning improves long-term learning and memory of neonatal hypoxia-ischemia brain damage (HIBD) rats, and whether the PI3K/Akt pathway and ... | Sevoflurane postconditioning exerts a neuroprotective effect against HIBD in neonatal rats via PI3K/Akt/eNOS and PI3K/Akt/GSK-3β pathways, and blockage of mPTP opening may be involved in attenuation of histomorphological injury. | yes |
26,525,371 | Does bariatric surgery acutely change the expression of inflammatory and lipogenic genes in obese adipose tissue? | {
"contexts": [
"Adipose tissue of obese subjects is known to exhibit increased inflammatory activity linked to altered expression of factors involved in glucose and lipid metabolism. The surgical procedure constitutes an injury per se, evoking a systemic inflammatory response.",
"To evaluate changes in the e... | Bariatric surgery acutely changes the expression of inflammatory and lipogenic genes in adipose tissue. This information should be considered cautiously when designing studies to assess adipose tissue gene expression in morbidly obese patients. The same timing of sampling is mandatory. | yes |
26,530,229 | Do unmet needs mediate the relationship between symptoms and quality of life in breast cancer survivors? | {
"contexts": [
"This study aimed to compare the symptoms, unmet needs, and QoL reported by women at 6 months to <2 years and 2 to 5 years following surgery and adjuvant treatment for breast cancer. It also evaluated the relationships among symptoms, unmet needs, and QoL using structural equation modeling.",
... | Results suggest that breast cancer survivors continue to endure many symptoms independent of the survivorship period. The unmet needs mediate the relationship between symptom burden and survivors' QoL. | yes |
26,541,479 | Is epidural analgesia superior to local infiltration analgesia in children with cerebral palsy undergoing unilateral hip reconstruction? | {
"contexts": [
"Treatment of postoperative pain in children with cerebral palsy (CP) is a major challenge. We investigated the effect of epidural analgesia, high-volume local infiltration analgesia (LIA), and an approximated placebo control on early postoperative pain in children with CP who were undergoing unil... | Epidural analgesia is superior to local infiltration analgesia for early postoperative pain management in children with cerebral palsy who undergo unilateral hip reconstruction. | yes |
26,526,856 | Do prevalence of pseudobulbar affect symptoms and clinical correlates in nursing home residents? | {
"contexts": [
"Pseudobulbar affect (PBA) is a neurological disorder of emotional expression, characterized by uncontrollable episodes of crying or laughing in patients with certain neurological disorders affecting the brain. The purposes of this study were to estimate the prevalence of PBA in US nursing home re... | Pseudobulbar affect symptoms were present in 17.5% of nursing home residents with neurological conditions, and 9.0% of residents overall. Increasing awareness and improving diagnostic accuracy of PBA may help optimize treatment. Copyright © 2015 John Wiley & Sons, Ltd. | yes |
26,552,486 | Do mycobacterium tuberculosis secretory proteins downregulate T cell activation by interfering with proximal and downstream T cell signalling events? | {
"contexts": [
"Mycobacterium tuberculosis (M. tuberculosis) modulates host immune response, mainly T cell responses for its own survival leading to disease or latent infection. The molecules and mechanisms utilized to accomplish immune subversion by M. tuberculosis are not fully understood. Understanding the mo... | To the best of our knowledge, this is the first study to investigate effect of Ag85A and ESAT-6 on TCR- and TCR/CD28- induced upstream and downstream signalling events of T-cell activation in TB patients. This study showed the effect of secretory antigens of M. tuberculosis in the modulation of T cell signalling pathwa... | yes |
26,537,003 | Does biochar-amended potting medium reduce the susceptibility of rice to root-knot nematode infections? | {
"contexts": [
"Biochar is a solid coproduct of biomass pyrolysis, and soil amended with biochar has been shown to enhance the productivity of various crops and induce systemic plant resistance to fungal pathogens. The aim of this study was to explore the ability of wood biochar to induce resistance to the root-... | These results suggest that biochar amendments protect rice plants challenged by nematodes. This priming effect partially depends on the ET signaling pathway and enhanced H2O2 accumulation. | yes |
26,527,653 | Does p53 Activity dominate That of p73 upon Mdm4 Loss in Development and Tumorigenesis? | {
"contexts": [
"Mdm4 negatively regulates the p53 tumor suppressor. Mdm4 loss in mice leads to an embryonic lethal phenotype that is p53-dependent. Biochemical studies indicate that Mdm4 also binds p73, a member of the p53 family, with higher affinity than p53. In this study, the significance of the Mdm4 and p73... | Genetic characterization of the Mdm4 and p73 interaction during development and tumorigenesis suggests new insight into the role of p53 family members, which may influence treatment options for patients. | yes |
26,539,739 | Do lymphocyte depletion and subset alteration correlate to renal function in chronic kidney disease patients? | {
"contexts": [
"It is widely accepted that chronic renal failure is associated with severe alterations of immune system. However, few studies looked into the immune alteration in earlier stage of chronic kidney disease (CKD) patients. To characterize immune defect in CKD patients, we performed lymphocyte subset ... | Lymphocyte depletion and subset alteration occurred during the progress of CKD. Further studies are needed to clarify the role of immune system in CKD and to expand our knowledge about the effect of uremia on the structure and function of immune system. | yes |
26,525,528 | Does locomotor Adaptability Task promote Intense and Task-Appropriate Output From the Paretic Leg During Walking? | {
"contexts": [
"To test the hypothesis that participants with stroke will exhibit appropriate increase in muscle activation of the paretic leg when taking a long step with the nonparetic leg compared to during steady-state walking, with a consequent increase in biomechanical output and symmetry during the stance... | These findings support the assertion that the nonparetic long-step task may be effective for use in poststroke locomotor rehabilitation to engage the paretic leg and promote recovery of walking. | yes |
26,546,790 | Are anticipatory and consummatory effects of ( hedonic ) chocolate intake associated with increased circulating levels of the orexigenic peptide ghrelin and endocannabinoids in obese adults? | {
"contexts": [
"Hedonic hunger refers to consumption of food just for pleasure and not to maintain energy homeostasis. Recently, consumption of food for pleasure was reported to be associated with increased circulating levels of both the orexigenic peptide ghrelin and the endocannabinoid 2-arachidonoyl-glycerol ... | When motivation to eat is generated by exposure to, and consumption of, chocolate a peripheral activation of specific endogenous rewarding chemical signals, including ghrelin, AEA, and 2-AG, is observed in obese subjects. Although preliminary, these findings predict the effectiveness of ghrelin and endocannabinoid anta... | yes |
26,546,793 | Is social interaction associated with changes in infants ' motor activity? | {
"contexts": [
"In developmental research, infants are commonly assumed to be early stakeholders in interactions with their caregivers. The tools that infants can use to interact with others vary from visual contact to smiling or vocalizing, and also include motor activity. However, surprisingly few studies have... | These results are in line with those reported by previous studies and confirm the relevance of using motor activity to delineate the early forms of interactive episodes in infants. | yes |
26,545,669 | Does gANODERMA LUCIDUM improve PHYSICAL FITNESS IN WOMEN WITH FIBROMYALGIA? | {
"contexts": [
"fibromyalgia is a chronic disease characterized by generalized pain, stiffness, poor physical conditioning, non-restorative sleep and poor health-related quality of life. Ganoderma lucidum a type of mushroom that has demonstrated several benefits in different populations. Ceratonia siliqua is a n... | Ganoderma lucidum may improve physical fitness in women with fibromyalgia, whereas, Ceratonia siliqua seemed to be ineffective at increasing physical fitness. These results may indicate that Ganoderma lucidum might be a useful dietary supplement to enhance physical performance of the patients suffering from fibromyalgi... | yes |
26,525,280 | Is expression of epigenetic modifiers significantly altered by exposure to secondhand smoke? | {
"contexts": [
"Secondhand smoke (SHS) is a major risk factor for lung cancer in nonsmokers. DNA damage-derived mutagenicity is a well-established mechanism of SHS-carcinogenicity; however very little is known about the impact of SHS exposure on the epigenome.",
"We have investigated whether exposure to SHS ... | Quantification of the expression of genes encoding DNA methyltransferases (Dnmt1, Dnmt3a, Dnmt3b and Dnmt3l), methyl binding domain proteins (Mecp2, Mbd2 and Mbd3) and histone deacetylases (Hdac1 and Hdac2) by quantitative reverse-transcription polymerase chain reaction analysis showed modest but not statistically sign... | no |
26,546,610 | Does a novel N-acetyl-glucosamine lectin of Lonchocarpus araripensis attenuate acute cellular inflammation in mice? | {
"contexts": [
"This study had investigated the anti-inflammatory activity of a seed lectin (LAL) isolated from Lonchocarpus araripensis.",
"LAL was purified by affinity chromatography (chitin column) and ion exchange chromatography (DEAE-Sephacel). In vitro LAL was tested for hemagglutinating activity again... | The novel N-acetyl-D-glucosamine-binding lectin isolated from L. araripensis seeds presents anti-inflammatory effect involving the lectin domain and the inhibition of 5-HT, BK, PGE2, NO, TNF-α and leukocyte rolling and adhesion. | yes |
26,546,611 | Is mortality in patients with non-functioning pituitary adenoma increased : systematic analysis of 546 cases with long follow-up? | {
"contexts": [
"Non-functioning pituitary adenomas (NFAs) have a prevalence of 7-22/100,000 people. A significant number of patients suffer from morbidities related to the tumor, possible recurrence(s), and treatments utilized. Our aim was to assess mortality of patients with macroNFA and predictive factors.",
... | Despite the improvement of treatments over the last three decades, the mortality of patients with NFAs in our series remains high. Apart from age, factors related with the management/outcome of the tumor are not independent predictors, and pituitary hormone deficits managed with the currently-used substitution protocol... | yes |
26,546,617 | Does combination of Photodynamic Therapy and Specific Immunotherapy Efficiently eradicate Established Tumors? | {
"contexts": [
"The efficacy of immunotherapy against advanced cancer may be improved by combination strategies. Photodynamic therapy (PDT) is a local tumor ablation method based on localized activation of a photosensitizer, leading to oxygen radical-induced tumor cell death. PDT can enhance antitumor immune res... | We show that immunotherapy can be efficiently combined with PDT to eradicate established tumors, based on strong local tumor ablation and the induction of a robust systemic immune response. These results suggest combination of active immunotherapy with tumor ablation by PDT as a feasible novel treatment strategy for ad... | yes |
26,531,184 | Does age affect the clinical and radiological outcomes after open-wedge high tibial osteotomy? | {
"contexts": [
"Open-wedge high tibial osteotomy (OWHTO) is a well-established procedure in the management of medial compartment osteoarthritis and osteonecrosis of the medial femoral condyle. Several studies have evaluated factors that negatively influence outcomes. However, few reports have investigated the ef... | OWHTO using the rigid long plate was an effective procedure independent of patient's age. The results showed that age did not influence the clinical and radiological outcomes after OWHTO. | no |
26,531,183 | Do patient-reported allergies cause inferior outcomes after total knee arthroplasty? | {
"contexts": [
"The main objective of this study was to analyse the outcomes after total knee arthroplasty (TKA) of a group of patients with at least one self-reported allergy and a group of patients without reported allergies. We hypothesized there is a significant negative influence on clinical outcome scores ... | Patients with at least one self-reported allergy have worse post-operative outcomes in terms of the WOMAC and KSS-Knee scores after TKA than patients without allergies. These poor outcomes do not seem to be related to depression. Therefore, more research is needed to explain them. Reported allergies could be considered... | yes |
26,547,127 | Do electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines? | {
"contexts": [
"Evaluate the cytotoxicity and genotoxicity of short- and long-term e-cigarette vapor exposure on a panel of normal epithelial and head and neck squamous cell carcinoma (HNSCC) cell lines.",
"HaCaT, UMSCC10B, and HN30 were treated with nicotine-containing and nicotine-free vapor extract from t... | E-cigarette vapor, both with and without nicotine, is cytotoxic to epithelial cell lines and is a DNA strand break-inducing agent. Further assessment of the potential carcinogenic effects of e-cigarette vapor is urgently needed. | yes |
26,551,455 | Does long non-coding MIAT mediate high glucose-induced renal tubular epithelial injury? | {
"contexts": [
"Long non-coding RNAs (lncRNAs) constitute a novel class of non-coding RNAs that take part in occurrence and development of diabetes complication via regulating gene expression. However, litter is known about lncRNAs in the setting of diabetes induced nephropathy. The aim of this study was to exam... | In summary, our data suggested that MIAT/Nrf2 served as an important signaling pathway for high glucose induced renal tubular epithelial injury. | yes |
26,526,814 | Do flowers of the early-branching papilionoid legume Petaladenium urceoliferum display unique morphological and ontogenetic features? | {
"contexts": [
"Floral development can help to shed light on puzzling features across flowering plants. The enigmatic Amazonian monospecific genus Petaladenium of the legume family (Leguminosae) had rarely been collected and only recently became available for ontogenetic studies. The fimbriate-glandular wing pet... | The floral ontogeny confirms the close affinity of P. urceoliferum with the florally heterogeneous, early-diverging papilionoid Amburaneae clade. The results strengthen the theory of a distinct experimental phase among early-branching papilionoid legumes during which a wider range of floral morphologies arose. Polysymm... | yes |
26,530,813 | Is the arterial tumor enhancement pattern on contrast-enhanced computed tomography associated with primary cancer death after radiofrequency ablation for small hepatocellular carcinoma? | {
"contexts": [
"Critical recurrences after radiofrequency ablation for hepatocellular carcinoma (HCC), such as intrahepatic metastases or dissemination, and extrahepatic metastases or seeding, which are difficult to treat radically, almost certainly lead to primary cancer death. The present study aimed to clarif... | Arterial heterogeneous tumor enhancement on CECT is associated with critical recurrence and cancer death after RFA for small HCC. | yes |
26,553,304 | Is informed consent instead of assent appropriate in children from the age of twelve : Policy implications of new findings on children 's competence to consent to clinical research? | {
"contexts": [
"For many decades, the debate on children's competence to give informed consent in medical settings concentrated on ethical and legal aspects, with little empirical underpinnings. Recently, data from empirical research became available to advance the discussion. It was shown that children's compet... | Although assessment of children's competence has a normative character, ethics, law and clinical practice can benefit from research data. The findings may help to do justice to the capacities children possess and challenges they may face when deciding about treatment and research options. We discuss advantages and draw... | yes |
26,530,998 | Is vacuum-assisted biopsy a viable alternative to surgical biopsy in the investigation of breast lesions of uncertain malignant potential? | {
"contexts": [
"In patients presenting with a breast lesion, when initial core biopsy histology falls into the category of \"uncertain malignant potential\" (i.e. a B3 lesion), the next line of investigation has traditionally been a surgical biopsy (SBx). Vacuum-assisted biopsy (VAB) may be a viable minimally in... | The increase in VAB use over time suggests that the procedure is well tolerated. The results demonstrate a VAB sensitivity of 92% for carcinoma diagnosis. In 96% of cases (150 of 156), VAB results were conclusive enough to avoid a subsequent SBx. This data suggests that VAB may be a preferable alternative to surgical b... | yes |
26,531,071 | Is anticholinergic burden associated with recurrent and injurious falls in older individuals? | {
"contexts": [
"While the anticholinergic activity of medications has been linked to cognitive decline, few studies have linked anticholinergic burden with falls in older people. We evaluated the relationship between anticholinergic burden and recurrent and injurious falls among community-dwelling older adults."... | The association between recurrent and injurious falls and the use of any medications listed in the ACB scale was mediated through gait and balance impairment but not by muscular weakness, providing a novel insight into the potential mechanistic link between ACB and falls. Future studies should determine whether TUG and... | yes |
26,530,761 | Does a Radiation-Induced Hippocampal Vascular Injury Surrogate Marker predict Late Neurocognitive Dysfunction? | {
"contexts": [
"We aimed to develop a hippocampal vascular injury surrogate marker for early prediction of late neurocognitive dysfunction in patients receiving brain radiation therapy (RT).",
"Twenty-seven patients (17 males and 10 females, 31-80 years of age) were enrolled in an institutional review board-... | The early hippocampal vascular dose response could be a predictor of late neurocognitive dysfunction. A personalized hippocampus sparing strategy may be considered in the future. | yes |
26,537,234 | Does prolonged use of human insulin increase breast cancer risk in Taiwanese women with type 2 diabetes? | {
"contexts": [
"Human insulin is commonly used to treat hyperglycemia in patients with diabetes, but its potential link with female breast cancer is under debate. This study investigated whether human insulin use might be associated with breast cancer risk in Taiwanese women with type 2 diabetes.",
"The reim... | This study discloses a significantly higher risk of breast cancer associated with prolonged use of human insulin. The increased risk of breast cancer associated with human insulin use may be modified by medications such as metformin, statin and ACEI/ARB. | yes |
26,546,482 | Do patients with ClearCode34-identified molecular subtypes of clear cell renal cell carcinoma represent unique populations with distinct comorbidities? | {
"contexts": [
"The 34-gene classifier, ClearCode34, identifies prognostically distinct molecular subtypes of clear cell renal cell carcinoma (ccRCC) termed clear cell A (ccA) and clear cell B (ccB). The primary objective of this study was to describe clinical characteristics and comorbidities of relevance in pa... | ClearCode34, after considering distinct patterns of comorbidities in each molecular subtype, remains a strong prognostic tool in patients with ccRCC. Obesity and diabetes mellitus emerged as factors that may influence ccRCC phenotypes and further studies investigating the effect of these metabolic conditions functional... | yes |
26,547,353 | Is [ Nucleolin expression correlated with carcinogenesis and progression of cervical squamous cell carcinoma ]? | {
"contexts": [
"To investigate the differential expressions of nucleolin in invasive cervical squamous cell carcinoma, cervical intraepithelial neoplasms (CIN) and normal cervical epithelial tissues and explore the role of nucleolin in the carcinogenesis and progression of cervical squamous cell carcinoma.",
... | Overexpression of nucleolin plays an important role during carcinogenesis of cervical squamous cell carcinoma and is positively correlated with tumor progression of CIN and cervical squamous cell carcinoma. | yes |
26,547,355 | Do impaired post-tetanic potentiation of muscle twitch in myasthenia gravis? | {
"contexts": [
"The aim of this study was to evaluate post-tetanic potentiation of muscle twitch in myasthenia gravis (MG).",
"Post-tetanic potentiation was evaluated by recording the compound muscle action potential (CMAP) of abductor pollicis brevis and movement-related potential (MRP) of the thumb using a... | Post-tetanic potentiation of muscle twitch is significantly diminished in MG, suggesting impaired excitation-contraction coupling. | yes |
26,554,390 | Does a novel acetylcholinesterase inhibitor and calcium channel blocker SCR-1693 improve Aβ25-35-impaired mouse cognitive function? | {
"contexts": [
"The mechanism involved in AD is complex, which has prompted to develop compounds that could simultaneously interact with several potential targets. Here, we report a new synthesized compound SCR-1693 which is designed to target both AChE and calcium channels that are potential for AD therapy.",
... | All these findings indicated that SCR-1693, as a double-target-direction agent, is a considerable candidate for AD therapy. | yes |
26,528,707 | Is rANK/OPG ratio of expression in primary clear-cell renal cell carcinoma associated with bone metastasis and prognosis in patients treated with anti-VEGFR-TKIs? | {
"contexts": [
"Bone metastases (BMs) are associated with poor outcome in metastatic clear-cell renal carcinoma (m-ccRCC) treated with anti-vascular endothelial growth factor tyrosine kinase inhibitors (anti-VEGFR-TKIs). We aimed to investigate whether expression in the primary tumour of genes involved in the de... | RANK/OPG ratio of expression in primary ccRCC is associated with BM and prognosis in patients treated with anti-VEGFR-TKIs. Prospective validation is warranted. | yes |
26,526,356 | Does a Her2-let-7-β2-AR circuit affect prognosis in patients with Her2-positive breast cancer? | {
"contexts": [
"Our previous studies show that β2-adrenergic receptor (β2-AR) is highly expressed in most Her2-overexpressing breast cancers. However, the mechanisms underlying upregulation of the β2-AR expression in Her2-overexpressing breast cancer cells are not fully understood. The clinical significance of t... | The mutual and reciprocal interaction between Her2, β2-AR, and let-7f may maintain a high level of β2-AR in breast cancer cells. Our data suggest that β2-AR may be a new useful biomarker for predicting prognosis in Her2-positive breast cancer and may also be a promising selective therapeutic target for the aggressive s... | yes |
26,544,895 | Does mutant GDF15 present a poor prognostic outcome for patients with oral squamous cell carcinoma? | {
"contexts": [
"To investigate the mutation status of growth differentiation factor 15 (GDF15) in patients with oral squamous cell carcinoma (OSCC), as well as the prognostic value of missense GDF15 mutations.",
"Formalin-fixed paraffin-embedded biopsy samples from 46 OSCC patients were involved in this stud... | Patients with missense GDF15 mutations have significantly poorer outcomes than those with wild-type GDF15, missense GDF15 mutations could be used as an independent increased risk factor of poor prognosis in OSCC patients. | yes |
26,546,573 | Does thiosulfate mediate Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia? | {
"contexts": [
"Hydrogen sulfide (H2S) exhibits protective effects in various disease models including cerebral ischemia-reperfusion (I/R) injury. Nonetheless, mechanisms and identity of molecules responsible for neuroprotective effects of H2S remain incompletely defined. In the current study, we observed that t... | The protective effects of H2S are mediated by thiosulfate that is transported across cell membrane by NaS-2 and exerts antiapoptotic effects via persulfidation of caspase-3. Given the established safety track record, thiosulfate may be therapeutic against ischemic brain injury. | yes |
26,540,164 | Is zFX a Strong Predictor of Poor Prognosis in Renal Cell Carcinoma? | {
"contexts": [
"This study was designed to assay the expression of zinc finger protein X-linked (ZFX) in renal cell carcinoma (RCC) tissues and evaluate the correlation between ZFX expression and prognosis of RCC patients.",
"The expressions of ZFX mRNA in 53 RCC tissues and 51 normal tissues were determined... | Our findings show that ZFX could be considered as a predictor for prognosis of RCC patients. | yes |
26,543,079 | Does oligo-based High-resolution aCGH Analysis enhance Routine Cytogenetic Diagnostics in Haematological Malignancies? | {
"contexts": [
"The purpose of the present study was to evaluate the detection rate of genomic aberrations in haematological malignancies using oligobased array-CGH (oaCGH) analysis in combination with karyotyping and fluorescence in situ hybridization (FISH) analyses, and its feasibility in a clinical pragmatic... | oaCGH analysis is a valuable asset in routine cytogenetics of haematological malignancies. | yes |
26,524,729 | Does systematic Tracking of Disrupted Modules identify Altered Pathways Associated with Congenital Heart Defects in Down Syndrome? | {
"contexts": [
"This work aimed to identify altered pathways in congenital heart defects (CHD) in Down syndrome (DS) by systematically tracking the dysregulated modules of reweighted protein-protein interaction (PPI) networks.",
"We performed systematic identification and comparison of modules across normal ... | We successfully identified 4 altered pathways and we predicted that these pathways would be good indicators for CHD in DS. | yes |
26,531,875 | Does iloprost and vitamin C attenuate acute myocardial injury induced by suprarenal aortic ischemia-reperfusion in rabbits? | {
"contexts": [
"The aim of this study was to evaluate antioxidant and cytoprotective effects of iloprost and Vitamin C in a distant organ after abdominal aorta ischemia-reperfusion injury.",
"Twenty-eight New Zealand rabbits weighing 2,400-2,800 g were used for this study. The rabbits were divided into four ... | This study clearly showed that myocardial injury and edema occurred after ischemia-reperfusion of abdominal aorta and that groups administered with iloprost and iloprost+vitamin C showed an attenuation of ischemia-reperfusion injury in distant organs (Tab. 3, Fig. 4, Ref. 30). | yes |
26,524,940 | Does pain intensity attenuate movement control of the lumbar spine in low back pain? | {
"contexts": [
"Pain intensity attenuates muscular activity, proprioception, and tactile acuity, with consequent changes of joint kinematics. People suffering from low back pain (LBP) frequently show movement control impairments of the lumbar spine in sagittal plane. This cross-sectional, observational study inv... | Our results indicate changes in movement control in people suffering from LBP. Whether decreased recurrence and determinism of lumbar movement patterns are intensifiers of LBP intensity or a consequence thereof should be addressed in a future prospective study. | yes |
26,543,727 | Does sildenafil treatment attenuate ventricular remodeling in an experimental model of aortic regurgitation? | {
"contexts": [
"Currently there is no reliable medical treatment for aortic regurgitation (AR).",
"Thirty-nine Sprague-Dawley rats underwent creation of AR or sham operation. Treated rats were assigned to early or late institution of sildenafil therapy (100 mg/kg/day) for a total of 10 weeks. Treatment-effec... | Sildenafil slightly inhibits LV remodeling and improves fractional shortening in rats with AR when treatment is initiated early. | yes |
26,527,864 | Does 4-Hydroxyisoleucine ameliorate an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression? | {
"contexts": [
"Obesity-associated insulin resistance (IR) is highly correlated with soluble tumor necrosis factor-α (sTNF-α), which is released from transmembranous TNF-α by TNF-α converting enzyme (TACE). In vivo, TACE activity is suppressed by tissue inhibitor of metalloproteinase 3 (TIMP3). Agents that can i... | 4-HIL improved an obesity-associated IR-like state in 3T3-L1 adipocytes by targeting TACE/TIMP3 and the insulin signaling pathway. | yes |
26,534,856 | Is a Western dietary pattern associated with higher blood pressure in Iranian adolescents? | {
"contexts": [
"The dietary determinants of adolescent blood pressure (BP) are not well understood. We determined the association between major dietary patterns and BP in a sample of Iranian adolescents.",
"This cross-sectional study was conducted among a representative sample (n = 557) of Shirazi adolescent... | The findings suggest that a Western dietary pattern is associated with higher BP in Iranian adolescents. However, additional large-scale prospective studies with adequate methodological quality are required to confirm these findings. | yes |
26,525,778 | Are e-cadherin regulators differentially expressed in the epithelium and stroma of keratocystic odontogenic tumors? | {
"contexts": [
"The epithelial-mesenchymal transition (EMT) is the process where cells lose their epithelial features and acquire properties of typical mesenchymal cells. The dissociation of tumor cells due to changes in cell-cell adhesion is one of the key principles of tumor invasion and EMT. Thus, the knowled... | The high immunoexpression of Snail and nuclear Slug in keratocystic odontogenic tumors suggests these proteins as transcription factors without necessarily participating in 'cadherin switching'. However, the knowledge of their induction of the epithelial-mesenchymal transition in odontogenic tumors is still limited. | yes |
26,547,756 | Does the Density of Interstitial Cells of Cajal be Diminished in Choledochal Cysts? | {
"contexts": [
"Interstitial cells of Cajal (ICC) have been shown to be present in the extrahepatic biliary tract of animals and humans. However, ICC distribution in choledochal cysts (CC) has not been investigated. A study was conducted to investigate the distribution of ICC in the extrahepatic biliary tract, i... | The scarcity of ICC in the extrahepatic biliary tract may be responsible for the etiopathogenesis of the CC. | yes |
26,547,754 | Is nerve Growth Factor Expression Associated with Perineural Invasion in Extrahepatic Cholangiocarcinoma? | {
"contexts": [
"Although the presence of perineural invasion has been recognized as a poor prognostic factor in extrahepatic cholangiocarcinoma, the molecular mechanisms of perineural invasion in extrahepatic cholangiocarcinoma remain unclear. Nerve growth factor has been reported to be a candidate predictive bi... | Intratumoral nerve growth factor expression is not associated with perineural invasion or recurrence-free and overall survival in patients with resected extrahepatic cholangiocarcinoma. | no |
26,542,767 | Do novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion? | {
"contexts": [
"Thyroid cancer stem cells (CSCs) with ALDH and CD44 markers contribute to tumor growth and aggressiveness. We hypothesized that novel HSP90 inhibitors (KU711, WGA-TA) and 17-AAG can effectively target the function of thyroid CSCs in vitro and prevent migration and invasion.",
"Validated papil... | KU711 and WGA-TA are novel HSP90 inhibitors targeting CSC function and inhibiting cell migration/invasion in differentiated and anaplastic thyroid cancers, warranting further translational evaluation in vivo. | yes |
26,542,686 | Is late follicular progesterone to estradiol ratio influenced by protocols or gonadotropins used? | {
"contexts": [
"Increased progesterone level during follicular phase seemed to be associated with decreased pregnancy rate.",
"A prospective cohort study, 1.1.2012 - 31.8.13. The Progesterone (P) and Progesterone/Estrogen (P/E2) level on ovulation induction day were compared between the protocols and the dif... | Endometrial receptivity is determined by the complex interactions of E2 and P. | no |
26,525,229 | Does airway factor XIII associate with type 2 inflammation and airway obstruction in asthmatic patients? | {
"contexts": [
"Coagulation Factor XIII (FXIII) plays an important role in wound healing by stabilizing fibrin clots and cross-linking extracellular matrix proteins. FXIII is expressed in cells of the monocyte/macrophage and dendritic cell lineages in response to type 2 cytokines.",
"We sought to determine t... | FXIII expression was upregulated in the airways of asthmatic patients after allergen exposure. Expression in the sputum of asthmatic patients correlated with the type 2 immune response and airflow limitation. Excessive activity of FXIII could contribute to the pathophysiology of airway obstruction in asthmatic patients... | yes |
26,530,191 | Does [ Nicotinic acid increase cellular transport of high density lipoprotein cholesterol in patients with hypoalphalipoproteinemia ]? | {
"contexts": [
"Plasma high density lipoproteins (HDL) are involved in reverse cholesterol transport mediated by the scavenger receptor class B type I (SR-BI). Nicotinic acid increases HDL cholesterol levels, even though its specific impact on SR-BI dependent-cellular cholesterol transport remains unknown.",
... | Nicotinic acid therapy increases SR-BI-dependent HDL cholesterol transport in cultured cells, establishing a new cellular mechanism by which this lipid-lowering drug appears to modulate HDL metabolism in patients with hypoalphalipoproteinemia. | yes |
26,541,592 | Does mother 's Self-Efficacy mediate the Relationship Between Household Food Insecurity and Maternal Infant Feeding Styles? | {
"contexts": [
"This study was performed to examine the association between household food insecurity, self-efficacy and infant feeding styles in mothers with children under 2 years old in Varamin, Iran.",
"In this cross-sectional study, 423 mothers aged 17-40 years from different areas of Varamin were selec... | Our findings suggest that performing interventions in order to enhance mother's self-efficacy in food insecure households can lead to improve positive maternal feeding behaviors. | yes |
26,535,066 | Does high Expression of FGFR4 enhance Tumor Growth and Metastasis in Nasopharyngeal Carcinoma? | {
"contexts": [
"FGF receptor (FGFR) family can be activated by FGFs and play important roles in regulating cell growth, differentiation, migration and angiogenesis. Recent studies suggested that FGFR4 could regulate several processes including tumor progression. Nasopharyngeal carcinoma (NPC) is a malignancy wit... | Our data suggested that FGFR4 might induce NPC progression and act as a potential therapeutic target in NPC. | yes |
26,535,063 | Is the Expression of CD9 and PIK3CD Associated with Prognosis of Follicular Lymphoma? | {
"contexts": [
"Follicular lymphoma (FL) frequently develops drug-resistance and transforms into more aggressive subtypes over time. It is urgent to find prognostic biomarkers and disclose signaling pathways that have potential to be drug targets. In this study, we investigated the association of FL prognosis wi... | Both CD9 and PIK3CD are prognostic markers of FL. The negative correlation between CD9 and PIK3CD expression suggests that there may be crosstalks of the 2 proteins in FL. | yes |
26,546,591 | Does treating hypertension in hemodialysis improve symptoms seemingly unrelated to volume excess? | {
"contexts": [
"Among hemodialysis patients, probing dry weight is an effective strategy for improving control of hypertension. Whether controlling hypertension improves or worsens symptoms among such patients remains unclear. The purpose of the study was to develop a tool to evaluate symptoms and examine the re... | Reducing BP through the use of a strategy that includes volume control and medication improves symptoms seemingly unrelated to volume excess. In long-term hemodialysis patients, treating hypertension using home BP measurements may improve well-being. | yes |
26,546,590 | Does micro-RNA analysis of renal biopsies in human lupus nephritis demonstrate up-regulated miR-422a driving reduction of kallikrein-related peptidase 4? | {
"contexts": [
"Aberrancies in gene expression in immune effector cells and in end-organs are implicated in lupus pathogenesis. To gain insights into the mechanisms of tissue injury, we profiled the expression of micro-RNAs in inflammatory kidney lesions of human lupus nephritis (LN).",
"Kidney specimens wer... | KLK4, a serine esterase with putative renoprotective properties, is down-regulated by miR-422a in LN kidney suggesting that, in addition to immune activation, local factors may be implicated in the disease. | yes |
26,530,544 | Is the Porphyromonas gingivalis O antigen required for inhibition of apoptosis in gingival epithelial cells following bacterial infection? | {
"contexts": [
"Porphyromonas gingivalis infection induces apoptosis inhibition in gingival epithelial cells; however, it is not fully understood which bacterial effectors are involved in this process. The aim of this study is to evaluate whether the P. gingivalis lipopolysaccharide (LPS), specifically the O-ant... | The O-antigen region of P. gingivalis LPS is required to increase gingival epithelial cell viability upon infection by bacteria and this increase is attributable to a reduction in apoptosis. Moreover, although bacterial internalization is required, the effects observed are not due to alterations in P. gingivalis adhere... | yes |
26,550,028 | Is stress-induced cortisol associated with generation of non-negative interpretations during cognitive reappraisal? | {
"contexts": [
"Enhanced processing of emotional stimuli after stress exposure is reported to be associated with stress-induced cortisol. Because enhanced emotional information processing could make cognitive emotion regulation more difficult, it was hypothesized that stress-induced cortisol would be associated ... | Although baseline cortisol and sex may have impacted the results, the results suggest that stress-induced cortisol is associated with difficulty in non-negative interpretation generation during the cognitive reappraisal process. | yes |
26,547,549 | Are the importance of the belief that `` light '' cigarettes smoother in misperceptions of the harmfulness of `` light '' cigarettes in the Republic of Korea : a nationally representative cohort study? | {
"contexts": [
"A number of countries have banned misleading cigarette descriptors such as \"light\" and \"low-tar\" as called for by the WHO Framework Convention on Tobacco Control. These laws, however, do not address the underlying cigarette design elements that contribute to misperceptions about harm. This is... | The strong association between the belief that "light" cigarettes are smoother on the throat and chest and the belief that "light" cigarettes are less harmful, which is consistent with previous research, provides further evidence of the need to not only ban "light" descriptors, but also prohibit cigarette design and pa... | yes |
26,535,588 | Are drug Transporter Genetic Variants Associated with TDF-Related Renal Dysfunction in Patients with HIV-1 Infection : A Pharmacogenetic Study? | {
"contexts": [
"To investigate whether single nucleotide polymorphisms (SNP) of drug transporter proteins for TDF is a risk factor for TDF-related renal function decrement.",
"This study investigated the association between 3 SNPs (ABCC2-24, 1249, and ABCB1 2677), which are shown to be associated with TDF-in... | SNPs of the drug transporters for TDF are not associated with clinically important renal outcomes in patients who initiated TDF-containing ART. | no |
26,535,357 | Do meniscus Injuries Alter the Kinematics of Knees With Anterior Cruciate Ligament Deficiency? | {
"contexts": [
"Most knee joint biomechanics studies have involved knees with an isolated anterior cruciate ligament (ACL) injury. However, a large portion of patients with injured ACLs have accompanied meniscus tearing. In this study, the in vivo alteration of knee biomechanics after tearing the ACL with or wit... | The results of this study demonstrate that a combined ACL/meniscus injury could alter the kinematics of ACL-injured knees in a different way compared with knees with isolated ACL tears, depending on the pattern of the meniscus tear. Considering the varying effect of meniscus injuries on knee joint kinematics, future st... | yes |
26,525,539 | Is aspirin-induced gastrointestinal damage associated with an inhibition of epithelial cell autophagy? | {
"contexts": [
"Aspirin (ASA) causes gastrotoxicity by hampering the epithelial defense against luminal contents through cyclooxygenase inhibition. Since cell survival in tough conditions may depend on rescue mechanisms like autophagy, we analyzed whether epithelial cells rely on this process to defend themselve... | Our data highlight the importance of autophagy in the gastric mucosa as a protective mechanism when the epithelium is injured. In the stomach, aspirin induces mucosal damage and reduces autophagy, thus, eliminating a protective mechanism that epithelial cells could use to escape death. We hypothesize that the combinati... | yes |
26,537,518 | Does iterative sub-network component analysis enable reconstruction of large scale genetic networks? | {
"contexts": [
"Network component analysis (NCA) became a popular tool to understand complex regulatory networks. The method uses high-throughput gene expression data and a priori topology to reconstruct transcription factor activity profiles. Current NCA algorithms are constrained by several conditions posed on... | Our framework enables reconstruction of large gene expression data networks, without reducing their size or pruning potentially important components, and at the same time rendering the results more biological plausible. Our ISNCA method is not only suitable for prediction of key regulators in cancer studies, but it can... | yes |
26,543,203 | Are deletions and de novo mutations of SOX11 associated with a neurodevelopmental disorder with features of Coffin-Siris syndrome? | {
"contexts": [
"SOX11 is a transcription factor proposed to play a role in brain development. The relevance of SOX11 to human developmental disorders was suggested by a recent report of SOX11 mutations in two patients with Coffin-Siris syndrome. Here we further investigate the role of SOX11 variants in neurodeve... | We thus propose that SOX11 deletion or mutation can present with a Coffin-Siris phenotype. | yes |
26,530,140 | Does high infiltration of mast cells positive to tryptase predict worse outcome following resection of colorectal liver metastases? | {
"contexts": [
"Accumulation of tumor-infiltrating mast cells (MCs) predicts poor survival in several cancers after resection. However, its effect on the prognosis of patients with colorectal liver metastases (CRLM) is not known.",
"Our retrospective study included 135 patients who underwent potentially cura... | High peritumoral MC infiltration predicts poor prognosis in patients who underwent hepatectomy for CRLM. The number of MCs in metastatic lesions is important for predicting the prognosis of CRLM patients and as an indication of therapy. | yes |
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