pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
26,545,527 | Does [ SNACK HIGH WHEY PROTEIN improve THE LEVEL OF SATIETY AND REDUCES APPETITE HEALTHY WOMEN ]? | {
"contexts": [
"the nutritional content and energy density of foods is related to greater control of appetite, satiety and reducing food intake.",
"the randomized crossover study included 20 healthy women, aged 20 and 30 years with a BMI of 20 to 24.9 kg/m2 and who completed that included 3 day trial compari... | snacks with less energy density and rich in protein (yogurt with PSL) improve the control of appetite, satiety and reduces food intake in healthy women later. | yes |
26,547,020 | Is amazonian delicacy tucupi as erosive as a cola-based soft drink? | {
"contexts": [
"Acidic diets are advocated as main risk factor for tooth erosion, which could be prevented, or at least controlled, if patients were early advised. It is important to identify, hence, if possible dietary constituents regionally consumed on large scale, such as tucupi, a low-pH yellowish-green col... | Besides the most worldwide appreciated cola-based soft drink, the greatly consumed Amazonian delicacy tucupi can be considered a potential risk factor for tooth erosion. | yes |
26,531,243 | Do instructions influence response to the Chinese version of the Movement-Specific Reinvestment Scale in community-dwelling older adults? | {
"contexts": [
"To examine whether differences emerged when the Chinese version of the Movement-Specific Reinvestment Scale (MSRS-C) was administered to community-dwelling older adults with instructions to respond in the context of \"general\" movements, walking, using chopsticks or dressing. Furthermore, the di... | Both the MSRS-C (general) and MSRS-C (walking) with a six-point or a four-point response format showed good discrimination of older fallers from non-fallers. Older adults might respond to the MSRS-C with respect to the most challenging movements (e.g. fall-related movements) in their daily living. Geriatr Gerontol Int ... | yes |
26,548,850 | Does abdominal compression during endoscopy ( the Bolster technique ) demonstrate hidden Schatzki rings ( with videos )? | {
"contexts": [
"Schatzki rings are found in the distal esophagus, are associated with hiatal hernias, and present with intermittent dysphagia to solid foods. They can be identified by radiology (GI series or barium swallow studies) or endoscopy. Rings are not always visualized during endoscopy in patients in who... | The Bolster technique is a simple maneuver that can increase detection rates of Schatzki rings during endoscopy. | yes |
26,552,329 | Does the pathogenic activity of anti-desmoglein autoantibodies parallel disease severity in rituximab-treated patients with pemphigus vulgaris? | {
"contexts": [
"Pemphigus vulgaris (PV) is an autoimmune blistering disease mediated by IgG autoantibodies targeting desmogleins (Dsgs). The anti-CD20 monoclonal antibody rituximab is increasingly used in corticosteroid-resistant PV patients. In a subset of rituximab-treated patients in remission, high ELISA ind... | Our findings have demonstrated the existence of non-pathogenic autoantibodies in PV patients in remission, establishing the basis for the design of a system able to precisely monitor the course of disease. | yes |
26,542,279 | Is elevated preoperative plasma D-dimer level a useful predictor of chemoresistance and poor disease outcome for serous ovarian cancer patients? | {
"contexts": [
"To examine whether the elevated preoperative plasma D-dimer levels show correlation with chemoresistance and poor prognosis in serous ovarian cancer patients.",
"Preoperative plasma D-dimer levels were measured in 125 patients with primary serous ovarian cancer (SOC).The correlations of plasm... | Elevated preoperative plasma D-dimer levels were associated with chemoresistance and poor disease outcome in serous ovarian cancer patients. Further validation of this easily available parameter as a promising prognostic biomarker for patients with SOC in prospective studies should be encouraged. | yes |
26,553,442 | Is preoperative Helicobacter pylori Infection Associated with Increased Survival After Resection of Gastric Adenocarcinoma? | {
"contexts": [
"Limited data exist on the prognosis of preoperative Helicobacter pylori (H. pylori) infection in gastric adenocarcinoma (GAC).",
"Patients who underwent curative-intent resection for GAC from 2000 to 2012 at seven academic institutions comprising the United States Gastric Cancer Collaborative... | Patients with and without preoperative H. pylori infection had few differences in adverse pathologic features at the time of gastric adenocarcinoma resection. Despite similar disease presentations, preoperative H. pylori infection was independently associated with improved OS. Further studies examining the interaction ... | yes |
26,540,134 | Is plasma cholesterol related to menstrual status in adolescent girls with eating disorders and weight loss? | {
"contexts": [
"This study examined the relationship between plasma cholesterol and circulating triiodothyronine and oestradiol in 561 adolescent girls aged 11-17 with eating disorders.",
"Plasma total cholesterol, high-density lipoprotein cholesterol, serum triodothyronine and oestradiol were measured at as... | Increased plasma total cholesterol was related to amenorrhoea in adolescent girls with eating disorders and weight loss. Oestrogens appeared to mediate the effect of starvation on cholesterol, most effectively in premenarcheal girls. Re-establishing menstruation is an important goal in the treatment of eating disorders... | yes |
26,546,460 | Does evodiamine inhibit the migration and invasion of nasopharyngeal carcinoma cells in vitro via repressing MMP-2 expression? | {
"contexts": [
"Evodiamine is one of active alkaloids isolated from the traditional Chinese medicine Evodia rutaecarpa Bentham and has various pharmacological properties. In this study, we investigated its effects on the migration, invasion, and associated mechanism in human nasopharyngeal carcinoma (NPC) cells.... | These findings demonstrate that evodiamine inhibits the migration and invasiveness of NPC cells, and it is probably a potential agent for the treatment of NPC invasion and metastasis. | yes |
26,547,334 | Is [ Low expression of SLC22A1 associated with a poor prognosis of hepatocellular carcinoma : analysis of 303 patients ]? | {
"contexts": [
"To evaluate the association between SLC22A1 expression and the outcomes of hepatocellular carcinoma (HCC) patients.",
"A tissue microarray of 303 HCC and matched adjacent noncancerous liver tissues (ANLTs) were constructed. The expression of SLC22A1 was tested by immunohistochemistry (IHC) an... | Down-regulation of SLC22A1 is a malignant feature and a potential prognostic marker of HCC. | yes |
26,535,391 | Do patients With Isolated PCL Injuries Improve From Surgery as Much as Patients With ACL Injuries After 2 Years? | {
"contexts": [
"Reports on outcome after posterior cruciate ligament (PCL) reconstruction often contain both isolated PCL and combined knee ligament injuries. This makes it difficult to conclude on the outcome after reconstruction of isolated PCL injuries.",
"To investigate the outcome after PCL reconstructi... | Patients undergoing PCL reconstruction can expect the same improvements in KOOS score as patients undergoing ACL reconstruction. However, PCL patients start out with an inferior score on average and consequently end up at a lower score compared with ACL patients for all KOOS subscales. | yes |
26,552,210 | Does [ Indirubin inhibit the proliferation of prostate cancer PC-3 cells ]? | {
"contexts": [
"To explore the antitumoral effect of indirubin on androgen-independent prostate cancer PC-3 cells and its possible mechanisms.",
"We measured the inhibitory effect of indirubin on the proliferation of prostate cancer PC-3 cells using MTT assay, detected their cell cycles by flow cytometry, an... | Indirubin can suppress the proliferation of androgen-independent prostate cancer PC-3 cells, which may be associated with its inhibitory effect on the cell cycle and Wnt signaling pathway. | yes |
26,552,216 | Does [ Intracytoplasmic sperm injection improve the clinical outcomes of the males with 100 % teratozoospermia ]? | {
"contexts": [
"To investigate whether intracytoplasmic sperm injection (ICSI) can improve the clinical outcomes of the male patients with 100% teratozoospermia.",
"We retrospectively analyzed the clinical data of 152 couples undergoing in vitro fertilization-embryo transfer (IVF-ET), including 75 cycles of ... | ICSI cannot improve the clinical outcomes of the male patients with 100% teratozoospermia. | no |
26,536,893 | Does triheptanoin dramatically reduce paroxysmal motor disorder in patients with GLUT1 deficiency? | {
"contexts": [
"On the basis of our previous work with triheptanoin, which provides key substrates to the Krebs cycle in the brain, we wished to assess its therapeutic effect in patients with glucose transporter type 1 deficiency syndrome (GLUT1-DS) who objected to or did not tolerate ketogenic diets.",
"We ... | Treatment with triheptanoin resulted in a 90% clinical improvement in non-epileptic paroxysmal manifestations and a normalised brain bioenergetics profile in patients with GLUT1-DS. | yes |
26,552,582 | Are hepatic myofibroblasts derived from Schistosoma mansoni-infected mice a source of IL-5 and eotaxin : controls of eosinophil populations in vitro? | {
"contexts": [
"Hepatic myofibroblasts are relevant for pathogenesis of S. mansoni infection. In normal liver, these perisinusoidal cells are quiescent, express the lipocyte phenotype, and are located in the Disse's space, being the major site of vitamin A storage. When activated, they convert to myofibroblasts ... | These results indicate that GR-MF may contribute to maintenance of local eosinophilia in schistosomal hepatic granulomas, and can function as immunoregulatory cells, besides their role in production of fibrosis. | yes |
26,541,037 | Does [ Single-tube Single-run Multiplex PCR detect Mixed Samples with Four Species of Plasmodium ]? | {
"contexts": [
"To establish a single-tube single-run multiplex PCR technique that can detect single or mixed samples with four species of Plasmodium.",
"Folding primers were designed based on the fast nested PCR. The reaction component concentrations were optimized and the primers were selected based on the... | FP-PCR is a simple and sensitive method for detecting both single-species and mixed infections with human Plasmodium, and can be applied for malaria diagnosis, screening and monitoring. | yes |
26,526,883 | Does apparent diffusion coefficient measurement covering complete tumor area better predict rectal cancer response to neoadjuvant chemoradiotherapy? | {
"contexts": [
"To determine the impact of two apparent diffusion coefficient (ADC) measurement techniques on diffusion-weighted magnetic resonance images (DW MRI) on the assessment of rectal cancer response to neoadjuvant chemoradiotherapy (CRT).",
"ADC values were measured prospectively with two different ... | The type of measurement technique significantly affected ADC results. ADC measurements covering a larger area better predicted tumor response to therapy. Post-CRT ADCs, regardless of the measurement technique, and numeric ADC change measured in the whole tumor volume accurately identified non-complete responders. Post-... | yes |
26,526,881 | Does a new Agkistrodon halys venom-purified protein C activator prevent myocardial fibrosis in diabetic rats? | {
"contexts": [
"To assess the effects of protein C activator (PCA) from Agkistrodon halys snake venom on cardiac fibrosis in streptozotocin (STZ) induced diabetic rat model, and investigate the mechanisms of its action.",
"PCA was identified by one-dimensional reversed phase liquid chromatography - mass spec... | Our results indicate that PCA has anti-fibrotic effects and that it may be used to treat myocardial fibrosis. | yes |
26,526,884 | Is real-time two-dimensional shear wave ultrasound elastography of the liver a reliable predictor of clinical outcomes and the presence of esophageal varices in patients with compensated liver cirrhosis? | {
"contexts": [
"Primary: to evaluate predictivity of liver stiffness (LS), spleen stiffness (SS), and their ratio assessed by real-time 2D shear wave elastography (RT-2D-SWE) for adverse outcomes (hepatic decompensation, hepatocellular carcinoma or death; \"event\") in compensated liver cirrhosis (LC) patients. ... | This is the first evaluation of RT-2D-SWE as a prognostic tool in LC. Although preliminary and gathered in a limited sample, our data emphasize the potential of LS to be a reliable predictor of clinical outcomes and the presence of EV in LC patients. | yes |
26,542,961 | Does porcine liver vascular bed in Biodur E20 corrosion cast? | {
"contexts": [
"Pigs are frequently used as animal models in experimental medicine. To identify processes of vascular development or regression, vascular elements must be recognised and quantified in a three-dimensional (3D) arrangement. Vascular corrosion casts enable the creation of 3D replicas of vascular tre... | Only Biodur E20®Plus appeared to be suitable for high-volume vascular corrosion casting due to its optimal permeability, sufficient processing time and minimum fragility. Biodur E20® Plus is slightly elastic, radio-opaque and alcohol-resistant. These properties make this acrylic resin suitable for not only vascular res... | yes |
26,524,810 | Are pregnancy-associated plasma protein a levels decreased in obstetric cholestasis? | {
"contexts": [
"Obstetric cholestasis is a cholestatic disease usually commencing in the third trimester of pregnancy and characterized by pruritus, elevation of liver enzymes, and increase in bile acids. The objective of this study was to compare the first trimester serum indicators of obstetric cholestasis wit... | In this study, the first trimester PAPP-A levels in the obstetric cholestasis cases were found to be significantly lower than the control group. Low PAPP-A levels should be a warning for obstetric cholestasis. | yes |
26,549,862 | Is atrophy of type I and II muscle fibers reversible in the case of grade > 2 fatty degeneration of the supraspinatus muscle : an experimental study in rabbits? | {
"contexts": [
"Although clinical investigations indicate that the limit of reversibility of rotator cuff muscles fibers type I and II atrophy is grade 2 of fatty degeneration (FD) according to the Goutallier computed tomography classification, little is known about the morphometric verification of these finding... | Atrophy of type I and II muscle fibers in rabbit supraspinatus muscle, characterized by grade >2 fatty degeneration according to the Goutallier computed tomography classification, is reversible after 24 weeks from reattachment of its tendon. A requirement for type I and II muscle fibers hypertrophy is a change in the b... | yes |
26,525,840 | Does pax6 influence expression patterns of genes involved in neuro- degeneration? | {
"contexts": [
"Pax6, a highly conserved multifunctional transcription factor, has been critical for neurogenesis and neuronal plasticity. It is presumed that if level of Pax6 approaches either low or null, critical genes responsible for maintaining functional status of neurons or glia would be modulated.",
... | Presence of BDNF and TGFβ indicates association between them in glioblastoma-astrocytoma. Therefore, Pax6 seems to be involved directly with p53 and TGFβ mediated pathways and indirectly with redox-sensitive pathway regulation. The neurodegenerative markers S100β, GFAP, BDNF, NGN2, p73α, p73δ, observed downregulated in... | yes |
26,552,477 | Is androgen receptor status highly conserved during tumor progression of breast cancer? | {
"contexts": [
"With the advent of new and more efficient anti-androgen drugs targeting androgen receptor (AR) in breast cancer (BC) is becoming an increasingly important area of investigation. This would potentially be most useful in triple negative BC (TNBC), where better therapies are still needed. The assess... | Most primary (87 %) and metastasized (86.1 %) BCs are AR positive including a significant fraction of TNBCs (11.4 %). Further, AR status is highly conserved during tumor progression and a change only occurs in a small fraction (4.1 %). Our study supports the notion that targeting AR could be effective for many BC patie... | yes |
26,555,125 | Do delays in Referral and Enrolment Are Associated With Mitigated Benefits of Cardiac Rehabilitation After Coronary Artery Bypass Surgery? | {
"contexts": [
"Cardiac rehabilitation (CR) is recommended after coronary artery bypass graft surgery; however, the consequences of longer wait times to start CR have not been elucidated.",
"Cardiopulmonary, demographic, and anthropometric assessments were conducted before and after 6 months of CR in consecu... | Strategies for timely access to CR at each phase of the process are important given the negative impact that wait time has on key clinical outcomes. This is relevant because optimizing VO2peak and attendance to CR has been shown to confer a mortality advantage. | yes |
26,536,980 | Are neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Predictors of Heart Failure? | {
"contexts": [
"Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are inflammatory markers used as prognostic factors in various diseases. The aims of this study were to compare the PLR and the NLR of heart failure (HF) patients with those of age-sex matched controls, to evaluate the pr... | NLR and PLR were higher in HF patients than in age-sex matched controls. However, NLR and PLR were not sufficient to establish a diagnosis of HF. NLR can be used to predict mortality during the follow-up of HF patients. | yes |
26,539,028 | Are tIMP1 , TIMP2 , and TIMP4 increased in aqueous humor from primary open angle glaucoma patients? | {
"contexts": [
"Elevated intraocular pressure (IOP) is the only known modifiable risk factor for primary open angle glaucoma (POAG), and it can be caused by reduced aqueous humor outflow from the anterior chamber. Outflow is predominantly regulated by the trabecular meshwork, consisting of specialized cells with... | An imbalance among MMPs and TIMPs was found in glaucomatous aqueous humor samples, with a shift toward raised TIMP levels. This may result in the inhibition of MMP activity, leading to an altered ECM composition in the TM and thereby contributing to increased outflow resistance. | yes |
26,539,026 | Does kCC2 expression supersede NKCC1 in mature fiber cells in mouse and rabbit lenses? | {
"contexts": [
"Na-K-Cl cotransporter 1 (NKCC1) and K-Cl cotransporter 2 (KCC2) have fundamental roles in neuron differentiation that are integrated with gamma-aminobutyric acid (GABA) and glutamate receptors, GABA synthesized by GAD25/65/67 encoded by GAD1/GAD2 genes, and GABA transporters (GATs). Cells in the ... | NKCC1 in peripheral elongating fiber cells is superseded by KCC2 expression in interior mature fiber cells that also express >20 additional integral GABA biology genes, AMPA/NMDA glutamate receptors, and an array of accessory proteins that together underlie morphogenesis in neurons. The present findings provide further... | yes |
26,528,903 | Are hCV viral load at baseline and at week 4 of telaprevir/boceprevir based triple therapies associated with virological outcome in HIV/hepatitis C co-infected patients? | {
"contexts": [
"As first generation HCV-specific protease inhibitors, boceprevir (BOC) or telaprevir (TVR) can achieve 60% to 70% sustained virological response (SVR) for HCV infected patients with genotype 1 infections, they could remain temporary a therapeutic option in patients living in resources limited cou... | Overall SVR12 was 63% and our results suggest that HIV/HCV coinfected patients with low HCV viral load (<800,000 IU/mL) and undetectable HCV-RNA after 4 weeks of triple therapy with TVR or BOC-based regimen have a higher probability of treatment success. | yes |
26,537,826 | Are the natural fenhexamid-resistant grey mould populations from strawberry in Zhejiang Province dominated by Botrytis cinerea group S? | {
"contexts": [
"Recently, a novel clade Botrytis cinerea group S was found to be common in B. cinerea populations from Germany and New Zealand. Fenhexamid, an effective antibotrytis fungicide, has not been registered in China, but our preliminary study detected fenhexamid-resistant (HydR) isolates from strawberr... | B. cinerea group S isolates are widespread in all strawberry-growing locations in Zhejiang Province. The natural HydR populations from strawberry are dominated by B. cinerea group S. © 2015 Society of Chemical Industry. | yes |
26,549,381 | Is a 7666-bp genomic deletion frequent in Chinese Han deaf patients with non-syndromic enlarged vestibular aqueduct but without bi-allelic SLC26A4 mutations? | {
"contexts": [
"To investigate the genetic cause of the patients with non-syndromic enlarged vestibular aqueduct (EVA) but without bi-allelic SLC26A4 mutations.",
"Presence of a homozygous genomic deletion was detected in a Chinese Han deaf patient (D1467-1) who failed to amplify the first three exons of SLC... | Our results suggested that the cryptic c.-2071_307+3801del7666 deletion of SLC26A4 is relatively frequent in Chinese Han non-syndromic EVA patients without bi-allelic SLC26A4 mutations. Screening of this genomic deletion should be incorporated into the routine DNA testing of SLC26A4 in Chinese Hans. | yes |
26,544,906 | Is cognitive and language performance in children associated with maternal social anxiety disorder : A study of young mothers in southern Brazil? | {
"contexts": [
"It has been shown that maternal mental health is associated with poorer skills development in the offspring. However, the evidence evaluating the association between social anxiety disorder (SAD) and cognitive or language development, is scarce.",
"To evaluate the association between maternal... | Our findings suggest that children with mothers suffering from SAD have poorer cognitive abilities and language skills. | yes |
26,534,905 | Are polymorphisms of dopamine pathway genes NRG1 and LMX1A associated with cognitive performance in bipolar disorder? | {
"contexts": [
"LIM homeobox transcription factor 1, alpha (LMX1A) and neuregulin 1 (NRG1) are susceptibility genes for schizophrenia that have been implicated in the dopaminergic pathway and have been associated with altered cognitive functioning. We hypothesized that single nucleotide polymorphisms (SNPs) in L... | The risk variants of the rs35753505 SNP were associated with increased performance in several cognitive domains and IQ, whereas the risk variants of the rs11809911 SNP in LMX1A was associated with reduced IQ and memory/learning. | yes |
26,525,894 | Does comparison of Xenorhabdus bovienii bacterial strain genomes reveal diversity in symbiotic functions? | {
"contexts": [
"Xenorhabdus bacteria engage in a beneficial symbiosis with Steinernema nematodes, in part by providing activities that help kill and degrade insect hosts for nutrition. Xenorhabdus strains (members of a single species) can display wide variation in host-interaction phenotypes and genetic potentia... | The analyses presented here demonstrate that while general mechanisms by which X. bovienii bacterial strains interact with their invertebrate hosts are similar, the specific molecules mediating these interactions differ. Our data support that adaptation of individual bacterial strains to distinct hosts or niches has oc... | yes |
26,536,829 | Is the relationship between insomnia with short sleep duration associated with hypercholesterolemia : a cross-sectional study? | {
"contexts": [
"To examine the association between insomnia with short sleep duration and hypercholesterolemia in Taiwanese adults.",
"Previous studies mostly focused on the association between sleep duration and hyperlipidemia, but the results were not consistent. Besides, very few studies extensively exami... | Insomnia with short sleep duration was associated with increased odds of hypercholesterolemia. Caregivers in clinical practice should watch out for the effect brought by this novel factor. | yes |
26,538,338 | Does radiographic Stage Correlate With Symptom Severity in Thumb Basilar Joint Osteoarthritis? | {
"contexts": [
"We hypothesize that thumb basilar joint osteoarthritis (TBJA) radiographic stage does not correlate with patient-reported measures of symptom severity.",
"Patients with unilateral TBJA who completed the 11-item QuickDASH (Disabilities of the Arm, Shoulder, and Hand), Short-Form 12 Health Surv... | Radiographic severity in TBJA does not correlate with validated patient-reported symptom scores. Metrics that link radiographic and subjective components of TBJA may improve surgical decision making and monitoring of treatment response. | no |
26,525,139 | Is anal cushion lifting method a novel radical management strategy for hemorrhoids that does not involve excision or cause postoperative anal complications? | {
"contexts": [
"To describe the anal cushion lifting (ACL) method with preliminary clinical results.",
"Between January to September 2007, 127 patients who received ACL method for hemorrhoid was investigated with informed consent. In this study, three surgeons who specialized in anorectal surgery performed t... | We consider that the ACL method might be better than all other current methods for managing hemorrhoids. | yes |
26,538,107 | Do feelings of worthlessness during a single complicated major depressive episode predict postremission suicide attempt? | {
"contexts": [
"To establish which symptoms of major depressive episode (MDE) predict postremission suicide attempts in complicated single-episode cases.",
"Using the nationally representative two-wave National Epidemiologic Survey on Alcohol and Related Conditions data set, we identified wave 1 lifetime sin... | Among depressive symptoms during an MDE, feelings of worthlessness is the only significant indicator of elevated risk of suicide attempt after the episode has remitted, beyond previous suicide attempts. | yes |
26,537,362 | Is tumor invasion depth a useful pathologic assessment for predicting outcomes in cervical squamous cell carcinoma after neoadjuvant radiotherapy? | {
"contexts": [
"To evaluate whether tumor invasion depth can be a reliable and easily applicable pathologic assessment strategy to predict outcomes using surgically resected cervical squamous cell carcinoma specimens from patients who have received neoadjuvant radiotherapy (RT) or concurrent chemoradiotherapy (C... | The TID or TIDC measured at the cervical internal surface is a useful and easily applied pathologic prognostic factor for distant metastasis and survival outcomes in patients with cervical squamous cell carcinoma treated with neoadjuvant RT or CCRT. | yes |
26,545,625 | Does endoscopic Mediastinal Staging in Lung Cancer be Superior to `` Gold Standard '' Surgical Staging? | {
"contexts": [
"The objective was to evaluate whether endobronchial ultrasonography (EBUS) or endoscopic ultrasonography (EUS) staging techniques of the mediastinum for lung cancer can change the treatment plan compared with the \"gold standard\" of surgical staging.",
"Patients were retrospectively identifi... | Combined EBUS- and EUS-guided biopsies can access more targets, including lung and distant metastasis, and thus have the potential to upstage patients compared with mediastinoscopy and change the treatment plan. | yes |
26,528,507 | Is colonoscopy performance stable during the course of an extended three-session working day? | {
"contexts": [
"Three-session days were introduced in our endoscopy unit to accommodate the increased demand resulting from the introduction of the National Health Service Bowel Cancer Screening Programme (BCSP). Cecal intubation rate (CIR) and adenoma detection rate (ADR) may decline with time during a standard... | Colonoscopy quality does not appear to depend on time of day or queue position in an extended three-session day. | yes |
26,528,030 | Does carbapenem Resistance in Non-Fermentative Bacterial Species and in Enterobacteriaceae isolate from Hospitalized Patients in Different Health-Care Settings? | {
"contexts": [
"Carbapenem-resistant strains have been increasingly reported over the last few years. In this study we used laboratory records to determine the occurrence of carbapenem-resistant strains from hospitalized patients with emphasis on the comparative analysis of the incidence in various health-care s... | Our study demonstrates that infections with carbapenem-resistant strains are correlated with hospitalization in intensive care units. Our data showed a predominant carbapenem-resistant Acinetobacter spp. strain in intensive care units. | yes |
26,546,191 | Is quality of Life in Thyroid Cancer Similar to That of Other Cancers with Worse Survival? | {
"contexts": [
"The incidence of thyroid cancer is increasing. As such, the number of survivors is rising, and it has been shown that their quality of life (QOL) is worse than expected. Using results from the North American Thyroid Cancer Survivorship Study (NATCSS), a large-scale survivorship study, we aim to c... | We found the self-reported QOL of thyroid cancer survivors in our study population is overall similar to or worse than that of survivors of other types of cancer surveyed with the same instrument. This should heighten awareness of the significance of a thyroid cancer diagnosis and highlights the need for further resear... | yes |
26,525,087 | Does motor Function be Associated With Incident Disability in Older African Americans? | {
"contexts": [
"Disability in older African American adults is common, but its basis is unclear. We tested the hypothesis that the level of motor function is associated with incident disability in older African Americans after adjusting for cognition.",
"A prospective observational cohort study of 605 older ... | Better motor function in older African Americans is associated with a decreased risk of developing disability. Moreover, the association of motor function and disability is stronger in individuals with better cognitive function. | yes |
26,525,088 | Does dietary Protein Intake be Protective Against Loss of Grip Strength Among Older Adults in the Framingham Offspring Cohort? | {
"contexts": [
"Age-related decline in muscle strength is an important public health issue for older adults. Dietary protein has been associated with maintenance of muscle mass, yet its relation to muscle strength remains unclear.",
"We determined the association of dietary protein (total, animal, and plant)... | Higher dietary intakes of total and animal protein were protective against loss of grip strength in community-dwelling adults aged 60 years and older. Increasing intake of protein from these sources may help maintain muscle strength and support prevention of mobility impairment in older adults. | yes |
26,541,923 | Is carotid stiffness associated with incident stroke : a systematic review and individual participant data meta-analysis? | {
"contexts": [
"Carotid stiffening is considered a key element in the pathogenesis of stroke. However, results of studies evaluating the association between carotid stiffness and incident stroke have been inconsistent.",
"This study investigated whether carotid stiffness (as determined by ultrasonography) is... | Carotid stiffness is associated with incident stroke independently of CV factors and aortic stiffness. In addition, carotid stiffness improves stroke risk prediction beyond Framingham and aortic stiffness. | yes |
26,541,776 | Does partial-Volume Effect Correction improve Quantitative Analysis of 18F-Florbetaben β-Amyloid PET Scans? | {
"contexts": [
"Neocortical atrophy reduces PET signal intensity, potentially affecting the diagnostic efficacy of β-amyloid (Aβ) brain PET imaging. This study investigated whether partial-volume effect correction (PVEC), adjusting for this atrophy bias, improves the accuracy of (18)F-florbetaben Aβ PET.",
"... | The influence of PVEC on (18)F-florbetaben PET data is associated with the degree of brain atrophy. Thus, PVEC increases the ability of (18)F-florbetaben PET to discriminate between AD patients and HCs, to detect Aβ plaques in the atrophic mesial temporal cortex, and potentially to evaluate changes in brain Aβ load ove... | yes |
26,545,101 | Is prolonged Operative Time to Extubation a Useful Metric for Comparing the Performance of Individual Anesthesia Providers? | {
"contexts": [
"One anesthesiologist performance metric is the incidence of \"prolonged\" (15 min or longer after dressing complete) times to extubation. The authors used several methods to identify the performance outliers and assess whether targeting these outliers for reduction could improve operating room wo... | Bayesian methodology with covariate adjustment is better suited to performance monitoring than an unadjusted, nonhierarchical frequentist approach because it is less likely to identify individuals spuriously as outliers. Targeting outliers in an effort to alter operating room activities is unlikely to have an operation... | no |
26,525,169 | Are tNNT2 Gene Polymorphisms Associated with Susceptibility to Idiopathic Dilated Cardiomyopathy in Kazak and Han Chinese? | {
"contexts": [
"Dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement, systolic dysfunction, and heart failure. Both genetic and non-genetic factors have been linked to DCM pathogenesis. Familial DCM (FDCM) accounts for 20%-50% of all DCM cases, highlighting the importance of genetics in ... | The TNNT2 polymorphisms might play an important role in susceptibility to DCM in Xinjiang Kazak and Han patients. | yes |
26,547,400 | Does complementary Serologic Investigations in Children with Celiac Disease be Unnecessary during Follow-Up? | {
"contexts": [
"To determine the frequency of nutritional deficiencies and thyroid dysfunction in children with celiac disease (CD) and during follow-up after initiation of a gluten-free diet. Laboratory investigations of hemoglobin, ferritin, calcium, folate, vitamin B12, vitamin D, and thyroid function are reg... | Complementary blood investigations are relevant at the time of diagnosis of CD but have little diagnostic yield during follow-up visits once the patient is placed on a gluten-free diet. Thus, we recommend that these variables only be assessed on indication, such as fatigue or abnormal growth. | yes |
26,530,958 | Does laboratory and dialysis characteristics in hemodialysis patients suffering from chronic itch -- result from a representative cross-sectional study? | {
"contexts": [
"A representative cross-sectional study showed that chronic itch (lasting for a minimum of 6 weeks) affects 25.2 % (point prevalence) of hemodialysis (HD) patients. Pathophysiology and etiology of chronic itch (CI) in HD are still unclear.",
"We investigated 860 HD patients from a representati... | Long-term follow-up studies will show if the type of dialysis membrane influences the development of CI in HD patients. It is most likely that several factors e.g. elevated parathormone, origin of end stage renal disease (ESRD), type of dialysis membrane, and a neuropathic component all contribute to the occurrence of ... | yes |
26,548,766 | Does proteomics of the red blood cell carbonylome during blood banking of erythrocyte concentrate? | {
"contexts": [
"Transfusion of red blood cells (RBCs) is a daily medical procedure. Erythrocyte concentrates (ECs) can be stored up to 56 days at 4 °C in saline additive solution mainly composed of adenine and sugar. Such nonphysiological conditions induce the occurrence of storage lesions, such as alterations o... | Affected cellular mechanisms involve antioxidant defenses, metabolism pathways, and proteasomal degradation. To better store RBCs those functions have to be preserved, which opens new routes of investigation in transfusion medicine. | yes |
26,543,546 | Does insulin combined with Chinese medicine improve glycemic outcome through multiple pathways in patients with type 2 diabetes mellitus? | {
"contexts": [
"Insufficient insulin secretion or inefficient insulin response are responsible for the clinical outcome of type 2 diabetes mellitus. Administration of insulin alone is prone to cause secondary effects, resulting in an unsatisfactory outcome. Shen-Qi-Formula (SQF), a well-known Chinese medicinal f... | The results from our study showed that the combination therapy of SQF and insulin significantly improved the clinical outcome of type 2 diabetes mellitus compared with insulin monotherapy. The mechanism of improvement was possibly involved in the multiple pathways. | yes |
26,543,542 | Is carbohydrate intake associated with time spent in the euglycemic range in patients with type 1 diabetes? | {
"contexts": [
"Greater glycemic variability and lack of predictability are important issues for patients with type 1 diabetes. Dietary factors are one of the contributors to this variability, but how closely diet is linked to glycemic fluctuation on a daily basis has not been investigated. We examined the assoc... | Carbohydrate intake is associated with time spent in euglycemia in patients with type 1 diabetes. | yes |
26,553,267 | Is metabolic Syndrome Associated with Increased Postoperative Morbidity and Hospital Resource Utilization in Patients Undergoing Elective Pancreatectomy? | {
"contexts": [
"In patients undergoing elective partial pancreatectomy, our aim was to evaluate the effect of metabolic syndrome (MS) on postoperative mortality, morbidity, and utilization of hospital resources. Our hypothesis was that MS is associated with worse surgical outcomes after pancreatectomy.",
"Fi... | MS is an under-emphasized predictor of increased postoperative morbidity and utilization of hospital resources in patients undergoing elective pancreatectomy. The effect of MS on these postoperative outcomes appears to be more pronounced for patients with benign rather than malignant indications for pancreatectomy and ... | yes |
26,536,696 | Do [ The preliminary study of the origin characters of snore in simple snorers ]? | {
"contexts": [
"to investigate the origin characters of snore in simple snorers and provide the basis for its treatment.",
"Thirty-two simple snorers diagnosed by polysomnography were induced to sleep by propofol and dexmedetomidine, then we observed the vibration sites, pattern and concomitant collapse of s... | The palatal fluttering is the main source of snoring sounds for most simple snorers, then followed by vibration of palatal and pharyngeal lateral wall together. The site of collapse in pharyngeal cavity is consistent with the main site of vibration. | yes |
26,545,531 | Does mATERNAL AND POST-WEANING EXPOSURE TO A HIGH FAT DIET promote VISCERAL OBESITY AND HEPATIC STEATOSIS IN ADULT RATS? | {
"contexts": [
"considering the frequent consumption of fat-rich diets by women of reproductive age, the aim of the present study was to investigate the effects of maternal consumption of a high-fat diet during the perinatal and/ or post-weaning period on the liver parameters and lipid metabolism of young rats."... | the food intake did not differ among the groups, however, the relative weight of the adipose tissue was higher in animals from the HC, HH and CH groups (p ≤ 0.005). Liver steatosis was found in the CH and HH animals, which also exhibited hypercholesterolemia (p ≤ 0.05). The levels of the liver enzymes alanine aminotran... | yes |
26,542,082 | Does vagus Nerve Stimulation During Rehabilitative Training improve Forelimb Recovery After Chronic Ischemic Stroke in Rats? | {
"contexts": [
"Stroke is a leading cause of long-term disability. Currently, there are no consistently effective rehabilitative treatments for chronic stroke patients. Our recent studies demonstrate that vagus nerve stimulation (VNS) paired with rehabilitative training improves recovery of function in multiple ... | VNS paired with rehabilitative training confers significantly greater recovery of forelimb function after chronic ischemic stroke in rats. | yes |
26,535,566 | Is reorganization of Azospirillum brasilense cell membrane mediated by lipid composition adjustment to maintain optimal fluidity during water deficit? | {
"contexts": [
"We study the Azospirillum brasilense tolerance to water deficit and the dynamics of adaptive process at the level of the membrane.",
"Azospirillum brasilense was exposed to polyethylene glycol (PEG) growth and PEG shock. Tolerance, phospholipids and fatty acid (FA) composition and membrane fl... | Azospirillum brasilense is able to perceive osmotic changes by changing the membrane fluidity. This effect is offset by changes in the composition of membrane phospholipid and FA, contributing to the homeostasis of membrane fluidity under water deficit. | yes |
26,544,583 | Is obesity associated with greater inflammation and monocyte activation among HIV-infected adults receiving antiretroviral therapy? | {
"contexts": [
"Among virally suppressed HIV-infected persons, we examined the relationship between obesity and alterations in key clinical markers of immune activation and inflammation. These markers have also been associated with excess HIV-related cardiovascular disease and mortality.",
"We evaluated data... | Obesity was prevalent and independently associated with greater monocyte activation and systemic inflammation. Research is needed to determine how adipose tissue excess is functionally related to persistent immunologic abnormalities among HIV-infected persons with viral suppression. | yes |
26,544,628 | Does dickkopf1 Up-Regulation Induced by a High Concentration of Dexamethasone promote Rat Tendon Stem Cells to Differentiate Into Adipocytes? | {
"contexts": [
"Dexamethasone (Dex)-induced spontaneous tendon rupture and decreased self-repair capability is very common in clinical practice. The metaplasia of adipose tissue in the ruptured tendon indicates that Dex may induce tendon stem cells (TSCs) to differentiate into adipocytes, but the mechanism remai... | In conclusion, by upregulating DKK1 expression, reducing the level of P-GSK-3β (ser9), and increasing the level of P-GSK-3β (tyr216), Dex causes the degradation of β-catenin, the central molecule of the classical WNT pathway, thereby inducing rat TSCs to differentiate into adipocytes. | yes |
26,545,961 | Is autophagy , which decreased in labouring fetal membranes , regulates IL-1β production via the inflammasome? | {
"contexts": [
"IL-1β plays a vital role in the terminal processes of human labour and delivery. Inflammasome activation is required to process pro IL-1β to an active, secreted molecule. Recent studies have shown that autophagy regulates IL-1β via the inflammasome. The aims were to determine the effect of (i) hu... | Autophagy is decreased in fetal membranes after spontaneous labour and delivery, and PPROM. Inhibition of autophagy regulates the secretion of IL-1β via inflammasome activation. IL-1β is a major contributor to the pathophysiology of spontaneous preterm birth. Therefore activation of autophagy may be a potential therape... | yes |
26,542,240 | Do protocol for a systematic review of quantitative burn wound microbiology in the management of burns patients? | {
"contexts": [
"Sepsis from burn injuries can result from colonisation of burn wounds, especially in large surface area burns. Reducing bacterial infection will reduce morbidity and mortality, and mortality for severe burns can be as high as 15 %. There are various quantitative and semi-quantitative techniques t... | Given the increasing use of quantitative methods, this is a timely systematic review, which will attempt to clarify the evidence base. As far as the authors are aware, it will be the first to address this topic. | yes |
26,535,138 | Are longer durations of antitumour necrosis factor treatment associated with reduced risk of cardiovascular events in patients with rheumatoid arthritis? | {
"contexts": [
"To assess the effects of treatment with antitumour necrosis factor (TNF) agents, methotrexate, or other non-biological disease-modifying antirheumatic drugs (DMARDs) on cardiovascular event risks among patients with rheumatoid arthritis (RA).",
"We conducted a retrospective study using data f... | Anti-TNF therapy was associated with a significantly lower risk of cardiovascular events among patients with RA, older patients with RA and patients without prior exposure to methotrexate. | yes |
26,526,395 | Do serum interferon-inducible protein 10 levels predict hepatitis B s antigen seroclearance in patients with chronic hepatitis B? | {
"contexts": [
"Hepatitis B s antigen (HBsAg) seroclearance is regarded as the optimal virological end-point.",
"To investigate the dynamic changes in serum cytokine levels around the time of HBsAg seroclearance.",
"This was a case-control study. Consecutive patients with chronic hepatitis B (CHB) who lo... | Lower serum IP-10 level at Year 0 was the only factor associated with HBsAg seroclearance. | yes |
26,544,579 | Does single oral dose of maraviroc prevent ex-vivo HIV infection of rectal mucosa in HIV-1 negative human volunteers? | {
"contexts": [
"Maraviroc (MVC) is a potential candidate for 'on demand' preexposure prophylaxis. In the present study, we evaluated the efficacy of a single oral dose of MVC to prevent ex-vivo HIV-1 infection of rectal tissue in humans.",
"Eight HIV-1-negative healthy volunteers received a single oral dose ... | An ex-vivo challenge with a single oral dose of MVC does not prevent ex-vivo infection of human rectal mucosa. The lack of prophylactic efficacy observed suggests that 'on demand' MVC preexposure prophylaxis would not prevent rectal HIV-1 transmission. | no |
26,525,964 | Are high levels of serum mannose-binding lectins associated with the severity and clinical outcomes of severe traumatic brain injury? | {
"contexts": [
"Mannose-binding lectin (MBL) is a key component of innate immunity. The expression of cortical MBL is up-regulated after clinical and experimental head trauma. This study aimed to assess the association of serum MBL levels with injury severity and long-term clinical outcomes after severe traumati... | Increased serum level of MBL was independently associated with head trauma severity and long-term clinical outcomes of STBI. | yes |
26,551,933 | Is functional dyspepsia associated with GNβ3 C825T and CCK-AR T/C polymorphism? | {
"contexts": [
"A polymorphism (C825T) in G-protein β polypeptide-3 (GNβ3) gene alters intracellular signal transduction, which may cause motor or sensory abnormalities in the gastrointestinal tract. Cholecystokinin-A receptor (CCK-AR) gene T/C polymorphism is associated with a defective splicing of the primary ... | TT genotype of GNβ3 C825T is more common among patients with FD than among HC, suggesting that increased signal transduction associated with this genotype may be important in its pathophysiology. However, CCK-AR polymorphism is protective against FD. | yes |
26,553,398 | Is a high-fat diet associated with otitis media with effusion? | {
"contexts": [
"An association between obesity and otitis media with effusion (OME) has been previously reported. The aim of this study was to evaluate the association between dietary intake and OME when adjusting obesity.",
"We analyzed the differences in dietary intake between children with/without OME who... | A high-fat diet was associated with OME and may represent a confounding factor between obesity and OME. | yes |
26,540,129 | Do large deletions play a minor but essential role in congenital coagulation factor VII and X deficiencies? | {
"contexts": [
"Congenital factor VII (FVII) and factor X (FX) deficiencies belong to the group of rare bleeding disorders which may occur in separate or combined forms since both the F7 and F10 genes are located in close proximity on the distal long arm of chromosome 13 (13q34). We here present data of 192 cons... | Large deletions play a minor but essential role in the mutational spectrum of the F7 and F10 genes. Copy number analyses (e. g. MLPA) should be considered if sequencing cannot clarify the underlying reason of an observed coagulopathy. Of note, in cases of combined FVII/FX deficiency, a deletion of the two contiguous ge... | yes |
26,535,381 | Does reconstruction of the Posterolateral Corner After Sequential Sectioning restore Knee Kinematics? | {
"contexts": [
"Various surgical techniques to treat posterolateral knee instability have been described. To date, the recommended treatment is an anatomic form of reconstruction in which the 3 key structures of the posterolateral corner (PLC) are addressed: the popliteofibular ligament, the popliteus tendon, an... | The PFL has a key role between 30° and 90° of flexion, and the lateral collateral ligament plays a role in extension. Reconstruction with the modified Larson technique restores these 2 complementary stabilizers of the knee. | yes |
26,528,456 | Is a Fixed Flow More Effective than Titrated Flow during Bubble Nasal CPAP for Respiratory Distress in Preterm Neonates? | {
"contexts": [
"The clinical effects of a pre-fixed flow of air-oxygen versus a flow titrated according to visible bubbling are not well understood.",
"To compare the effects of a fixed flow (5 L/min) and titrated flow (flow just enough to ensure bubbling) at different set pressures on delivered intra-prong ... | In preterm infants on bubble CPAP with set pressures of 4-6 cm H2O, a fixed flow of 5 L/min is more effective than a flow titrated to ensure adequate visible bubbling. It achieves higher delivered pressures, better oxygenation and ventilation. | yes |
26,552,209 | Does [ Crypotanshione reduce the expression of metadherin in DU145 prostate cancer cells ]? | {
"contexts": [
"To investigate the effects of crypotanshinone (CPT) on the proliferation and apoptosis of DU145 prostate cancer cells as well as on the metadherin expression and the downstream PI3K/AKT signaling pathway in the DU145 cells.",
"We treated DU145 prostate cancer cells with different concentratio... | CPT can inhibit the proliferation and induce the apoptosis of DU145 prostate cancer cells, which may be associated with its suppression of the downstream PI3K/AKT signaling pathway by reducing the expression of metadherin in the DU145 cells. | yes |
26,552,593 | Does microRNA367 negatively regulate the inflammatory response of microglia by targeting IRAK4 in intracerebral hemorrhage? | {
"contexts": [
"Intracerebral hemorrhage (ICH) induces microglial activation and the release of inflammatory cytokines, leading to inflammation in the brain. IRAK4, an essential component of the MyD88-dependent pathway, activates subsets of divergent signaling pathways in inflammation.",
"In the experiment, ... | In conclusion, our study demonstrates that miR-367/IRAK4 pathway plays an important role in microglial activation and neuroinflammation in ICH. Our finding also suggests that miR-367 might represent a potential therapeutic target for ICH. | yes |
26,553,053 | Is percutaneous biliary drainage oncologically inferior to endoscopic drainage : a propensity score matching analysis in resectable distal cholangiocarcinoma? | {
"contexts": [
"The aim of this study was to evaluate whether percutaneous transhepatic biliary drainage (PTBD) increases the incidence of seeding metastasis and shortens postoperative survival compared with endoscopic biliary drainage (EBD).",
"A total of 376 patients with distal cholangiocarcinoma who unde... | Compared with EBD, PTBD increases the incidence of seeding metastasis after resection for distal cholangiocarcinoma and shortens postoperative survival. | yes |
26,553,485 | Does risk factors for severe injury following indoor and outdoor fall in geriatric patients? | {
"contexts": [
"This study was performed to examine the characteristics of indoor and outdoor falls in older patients and the factors related to severe injury in the emergency department (ED).",
"In total, 26,515 patients fell indoors and 19,581 outdoors. The general and clinical characteristics were compare... | Transport to the ED by public ambulance or from another medical facility, and head and neck injury were risks for severe injury following indoor and outdoor falls in elderly subjects. Efforts to identify the risk factors for severe injury and for falling itself are important to prevent and reduce fall injuries in elder... | yes |
26,553,484 | Is visual impairment , but not hearing impairment , independently associated with lower subjective well-being among individuals over 95 years of age : A population-based study? | {
"contexts": [
"Sensory impairment affects an increasing number of elderly adults, with a negative psychological impact. Our objective was to examine the associations of visual and hearing impairment with subjective well-being (SWB), an important psychological concept defined by life satisfaction [LS], positive ... | Visual impairment, but not hearing impairment, was independently associated with low SWB among LLIs, and functional ability may play a mediating role in the observed relationship. The findings indicate that rehabilitation targeted for those with reduced vision and functioning in long-lived populations may be important ... | yes |
26,537,975 | Are adolescent Intermittent Alcohol Exposure : Dysregulation of Thrombospondins and Synapse Formation Associated with Decreased Neuronal Density in the Adult Hippocampus? | {
"contexts": [
"Adolescent intermittent alcohol exposure (AIE) has profound effects on neuronal function. We have previously shown that AIE causes aberrant hippocampal structure and function that persists into adulthood. However, the possible contributions of astrocytes and their signaling factors remain largely... | Repeated EtOH exposure during adolescence results in long-term changes in specific astrocyte signaling proteins and their neuronal synaptogenic receptor. Continued signaling by these traditionally developmental factors in adulthood may represent a compensatory mechanism whereby astrocytes reopen the synaptogenic window... | yes |
26,552,460 | Is obstructive sleep apnea with excessive daytime sleepiness associated with non-alcoholic fatty liver disease regardless of visceral fat? | {
"contexts": [
"Obstructive sleep apnea (OSA) is associated with an increased risk of obesity and non-alcoholic fatty liver disease (NAFLD), but it remains unclear whether the risk of NAFLD is independently related to OSA regardless of visceral obesity. Thus, the aim of the present study was to examine whether O... | In the present study, OSA was closely associated with NAFLD in Korean adults. This association was particularly strong in those with EDS or short sleep duration regardless of VFA. | yes |
26,526,974 | Does tobacco Use be Associated With Increased Complications After Anterior Cruciate Ligament Reconstruction? | {
"contexts": [
"The use of tobacco is a well-established cause of preventable morbidity and mortality. There have been few studies examining the effect of tobacco use on outcomes and complications after arthroscopic knee procedures such as anterior cruciate ligament (ACL) reconstruction.",
"To investigate th... | ACL reconstruction in patients who use tobacco is associated with significantly increased rates of infection, VTE, and subsequent ACL reconstruction compared with controls. There was no association between tobacco use and postoperative arthrofibrosis after primary ACL reconstruction. | yes |
26,549,756 | Do chemostat culture systems support diverse bacteriophage communities from human feces? | {
"contexts": [
"Most human microbiota studies focus on bacteria inhabiting body surfaces, but these surfaces also are home to large populations of viruses. Many are bacteriophages, and their role in driving bacterial diversity is difficult to decipher without the use of in vitro ecosystems that can reproduce hum... | Because the diversity of phages in these cultured fecal communities have similarities to those found in humans, we believe these communities can serve as valuable ecosystems to help uncover the role of phages in human microbial communities. | yes |
26,536,866 | Does mammalian prion protein ( PrP ) form conformationally different amyloid intracellular aggregates in bacteria? | {
"contexts": [
"An increasing number of proteins are being shown to assemble into amyloid structures that lead to pathological states. Among them, mammalian prions outstand due to their ability to transmit the pathogenic conformation, becoming thus infectious. The structural conversion of the cellular prion prot... | Overall, our results suggest that modelling PrP amyloid formation in microbial cell factories might open an avenue for a better understanding of the structural features modulating the pathogenic impact of this intriguing protein. | yes |
26,543,611 | Does the BCL11A-XL expression predict relapse in squamous cell carcinoma and large cell carcinoma? | {
"contexts": [
"The B cell leukemia 11A (BCL11A) gene was identified as a proto-oncogene in hematopoietic cell malignancies and breast cancer. Alternative RNA splicing generates three main transcripts designated as Extra-long (XL; 5.9 kb/125 kD), Long (L; 3.8 kb/100 kD) and Short (S; 2.4 kb/35 kD). Our previous ... | Our results demonstrated that the BCL11A-XL isoform might be a potential prognostic biomarker of SCC and LCC. | yes |
26,543,610 | Does analysis of pulmonary function test result in a health check-up population? | {
"contexts": [
"To explore the incidences of chronic obstructive pulmonary disease (COPD), obstructive ventilatory dysfunction, and obstructive small airway disease and their risk factors in a health check-up population, with an attempt to inform the early diagnosis and treatment of COPD.",
"Subjects who age... | Health check-up is an important approach for screening COPD, obstructive ventilator dysfunction, and obstructive small airway disease. Smoking cessation and controlling of relevant risk factors are helpful to lower the incidences of these conditions. | yes |
26,547,717 | Does notochord manipulation impact oesophageal and tracheal formation from isolated foregut in 3D explant culture? | {
"contexts": [
"Tracheo-oesophageal malformations result from disturbed foregut separation during early development. The notochord, a specialised embryonic structure, forms immediately adjacent to the dividing foregut. In the Adriamycin mouse model of oesophageal atresia, foregut and notochord abnormalities co-e... | The relationship between the embryonic foregut and notochord is complex and ill-defined; however, the notochord does not contribute essentially to oesophagus and trachea formation beyond E9 in the mouse, and the transplantation of additional notochord does not disrupt foregut separation in 3D explant culture. | no |
26,539,029 | Does down-regulation of microRNA-155 attenuate retinal neovascularization via the PI3K/Akt pathway? | {
"contexts": [
"We aimed to investigate the anti-angiogenic properties of miR-155 via in vitro and in vivo studies.",
"miR-155 was knocked down using lentivirus-mediated RNA interference. The proliferation, migration, and tube formation of human retinal microvascular endothelial cells (HRMECs) were measured ... | The results revealed that the downregulation of miR-155 attenuated retinal neovascularization via the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. | yes |
26,543,094 | Does allergic Lung Inflammation aggravate Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice? | {
"contexts": [
"Asthma and abdominal aortic aneurysms (AAA) both involve inflammation. Patients with asthma have an increased risk of developing AAA or experiencing aortic rupture. This study tests the development of one disease on the progression of the other.",
"Ovalbumin sensitization and challenge in mic... | This study suggests a pathological link between airway allergic disease and AAA. Production of one disease aggravates the progression of the other. | yes |
26,546,994 | Does adjuvant Stereotactic Radiosurgery reduce Need for Retreatments in Patients with Meningioma Residuals? | {
"contexts": [
"Radical surgical resection of cerebral meningiomas involving the dura mater of venous sinuses is challenging, and tumor residuals are frequently left after surgery. This study sought to evaluate the effect of adjuvant stereotactic radiosurgery (aSRS) on the time to significant growth of meningiom... | aSRS of meningioma residuals had a positive effect on tumor control and should be considered in patients with meningioma residuals. | yes |
26,543,004 | Does intrinsic Visual-Motor Synchrony correlate With Social Deficits in Autism? | {
"contexts": [
"Imitation, which is impaired in children with autism spectrum disorder (ASD) and critically depends on the integration of visual input with motor output, likely impacts both motor and social skill acquisition in children with ASD; however, it is unclear what brain mechanisms contribute to this im... | Our twice replicated findings confirm that visual-motor functional connectivity is disrupted in ASD. Furthermore, the observed temporal incongruity between visual and motor systems, which may reflect diminished integration of visual consequences with motor output, was predictive of the severity of social deficits and m... | yes |
26,527,360 | Is elevated plasma aldosterone an independent risk factor for erectile dysfunction in men? | {
"contexts": [
"Erectile dysfunction (ED) and cardiovascular disease (CVD) share a great number of common risk factors. There is growing evidence that aldosterone, an independent CVD risk factor, is associated with ED.",
"The purpose of this study was to determine the relationship between plasma aldosterone ... | We determined that elevated plasma aldosterone concentration is an independent risk factor for ED. Our findings also indicate that the aldosterone, a well-recognized contributor to vascular injury, might be a potential bond between ED and CVD. | yes |
26,548,538 | Is arterial Vasoreactivity Equally Affected by In Vivo Cross-Clamping with Increasing Loads in Young and Middle-Aged Mice Aortas? | {
"contexts": [
"To compensate for the lack of haptic feedback by surgical robots, limitation of exerted forces could be implemented. The limits should be based on the observed relationship between tissue load and induced damage. This study examines whether age-related changes influence this relationship.",
"... | Within the tested conditions, mechanical clamping induces damage to the vascular endothelium, but not to the smooth muscle cells. Age has no effect on the obtained results in mice from 10 to 40 weeks old. | yes |
26,526,716 | Does bCL3 reduce the Sterile Inflammatory Response in Pancreatic and Biliary Tissues? | {
"contexts": [
"Under conditions of inflammation in the absence of micro-organisms (sterile inflammation), necrotic cells release damage-associated molecular patterns that bind to Toll-like receptors on immune cells to activate a signaling pathway that involves activation of IκB kinase and nuclear factor κB (NF-... | BCL3 is up-regulated in inflamed pancreatic or biliary tissues from mice and patients with AP or cholangitis. Its production appears to reduce the inflammatory response in these tissues via blocking ubiquitination and proteasome-mediated degradation of p50 homodimers. | yes |
26,539,551 | Is regular Chinese Green Tea Consumption Protective for Diabetic Retinopathy : A Clinic-Based Case-Control Study? | {
"contexts": [
"To determine the association between regular Chinese green tea consumption and the risk of diabetic retinopathy (DR) in diabetic patients in China.",
"100 DR patients and 100 age-sex-matched diabetic controls without retinopathy were recruited in a clinic-based, case-control study. DR was def... | Diabetic patients who had regularly drunk Chinese green tea every week for at least one year in their lives had a DR risk reduction of about 50% compared with those who had not. Regular Chinese green tea consumption may be a novel approach for the prevention of DR. | yes |
26,530,211 | Do peak oxygen uptake during the incremental shuttle walk test in a predominantly female population with Chagas heart disease? | {
"contexts": [
"Chagas heart disease (CHD) patients may have a reduced functional capacity (FC). Field tests, as the Incremental Shuttle Walk Test (ISWT), can estimate peak oxygen uptake (VO2 peak). However, the relationship between the ISWT and the Cardiopulmonary Exercise Testing (CPET), the gold standard in t... | This study showed the good correlation between distance walked in ISWT and VO2 peak directly measured in both tests, and additionally, provided an equation to calculate a predictive VO2 peak by ISWT, suggesting a good alternative to evaluate the FC of CHD patients, especially in locations where sophisticated testing is... | yes |
26,548,628 | Is in ICU state anxiety associated with posttraumatic stress symptoms over six months after ICU discharge : A prospective study? | {
"contexts": [
"Posttraumatic stress symptoms are common after intensive care treatment. The influence of anxiety during critical illness on the development of posttraumatic stress symptoms needs to be investigated.",
"To determine the association between anxiety during critical illness (state and trait comp... | Posttraumatic stress symptoms occurred in a significant proportion of ICU survivors and were significantly associated with higher levels of trait anxiety, younger age, mental health treatment prior to the ICU admission and more symptoms of anxiety after ICU discharge. Early assessment and interventions directed to redu... | no |
26,525,574 | Does dense genotyping of immune-related loci identify HLA variants associated with increased risk of collagenous colitis? | {
"contexts": [
"Collagenous colitis (CC) is a major cause of chronic non-bloody diarrhoea, particularly in the elderly female population. The aetiology of CC is unknown, and still poor is the understanding of its pathogenesis. This possibly involves dysregulated inflammation and immune-mediated reactions in gene... | HLA genotype associates with CC, thus implicating HLA-related immune mechanisms in its pathogenesis. | yes |
26,543,364 | Are methotrexate-loaded lipid-core nanocapsules highly effective in the control of inflammation in synovial cells and a chronic arthritis model? | {
"contexts": [
"Rheumatoid arthritis (RA) is the most common autoimmune disease in the word, affecting 1% of the population. Long-term prognosis in RA was greatly improved following the introduction of highly effective medications such as methotrexate (MTX). Despite the importance of this drug in RA, 8%-16% of p... | The MTX-LNC were better than the MTX solution at reducing proinflammatory cytokines and T-cell-derived cytokines such as interferon-gamma and interleukin-17A. This result, combined with the reduction in the dose required for therapy, shows that MTX-LNC are a very promising system for the treatment of RA. | yes |
26,537,126 | Does sepsis impair microvascular autoregulation and delays capillary response within hypoxic capillaries? | {
"contexts": [
"The microcirculation supplies oxygen (O2) and nutrients to all cells with the red blood cell (RBC) acting as both a deliverer and sensor of O2. In sepsis, a proinflammatory disease with microvascular complications, small blood vessel alterations are associated with multi-organ dysfunction and poo... | Sepsis impaired microvascular autoregulation at both the individual capillary and erythrocyte level, seemingly uncoupling the RBC acting as an "O2 sensor" from microvascular autoregulation. Impaired microvascular autoregulation was manifested by increased capillary stopped-flow, increased capillary response time within... | yes |
26,537,124 | Does acute disruption of glucagon secretion or action improve glucose tolerance in an insulin-deficient mouse model of diabetes? | {
"contexts": [
"Normal glucose metabolism depends on pancreatic secretion of insulin and glucagon. The bihormonal hypothesis states that while lack of insulin leads to glucose underutilisation, glucagon excess is the principal factor in diabetic glucose overproduction. A recent study reported that streptozotocin... | Disruption of glucagon action/secretion did not improve glucose tolerance in diabetic mice. Near-total alpha cell elimination may have prevented further deterioration. Our findings support insulin lack as the major factor underlying hyperglycaemia in beta cell-deficient diabetes. | no |
26,536,542 | Does intracarotid Etomidate decrease the Interhemispheric Synchronization in Electroencephalogram ( EEG ) During the Wada Test? | {
"contexts": [
"The Wada test is a diagnostic method to anesthetize 1 cerebral hemisphere and assess the language and memory functions of awake contralateral hemisphere before temporal lobectomy in patients with epilepsy. The effects of an ipsilateral injection of etomidate on the functional properties of contra... | Our study showed that the EEG effects of intracarotid ipsilateral injection of etomidate is not uniform in both hemispheres. Decrease in the interhemispheric synchronization of delta waves might serve as an indicator of ipsilateral effect of etomidate on the brain. Additional studies are needed to confirm our findings. | yes |
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