pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
19,563,529 | Does the phospholipase A ( 2 ) inhibitor methyl indoxam suppress diet-induced obesity and glucose intolerance in mice? | {
"contexts": [
"Previous results have shown that mice lacking in the group 1B phospholipase A(2) (Pla2g1b) are resistant to obesity and diabetes induced by feeding a diabetogenic high-fat/high-carbohydrate diet. This study examined the potential of using the Pla2g1b inhibitor methyl indoxam as therapy to suppres... | These results show that oral supplementation of a diabetogenic diet with the Pla2g1b inhibitor methyl indoxam effectively suppresses diet-induced obesity and diabetes in mice. This suggests that Pla2g1b inhibition may be a potentially effective oral therapeutic option for treatment of obesity and diabetes. | yes |
19,567,520 | Do physiological thyroid hormone levels regulate numerous skeletal muscle transcripts? | {
"contexts": [
"Skeletal muscle is an important target tissue for thyroid hormone (TH). It is currently unknown which genes are regulated by physiological TH levels.",
"We examined the effects of l-thyroxine on human skeletal muscle transcriptome.",
"Microarray analysis of transcript levels was performed... | We demonstrated that physiological levels of TH regulate a myriad of genes in human skeletal muscle. The identification of novel putatively TH-responsive genes may provide the molecular basis of clinical effects in subjects with different TH status. The observation that TH regulates microRNAs reveals a new layer of com... | yes |
19,565,381 | Does evaluation of a new device to prevent fall in persons with Parkinson 's disease? | {
"contexts": [
"To compare walking characteristics of individuals with Parkinson's disease (PD) using a new walking aid, the WalkAbout, with usual walking.",
"Fifteen subjects with PD were recruited. Subjects walked in their usual fashion and then walked again in the WalkAbout. Gait parameters, 5-min walk, a... | The WalkAbout may help persons with PD who have more severe disability to walk farther. These data could be beneficial in selecting a helpful walking aid for persons with PD. | yes |
19,561,827 | Does higher inpatient medical surgical bed occupancy extend admitted patients ' stay? | {
"contexts": [
"Determine the effect that increased medical surgical (med/surg) bed occupancy has on the time interval from admission order to arrival in the bed for the patients admitted from the emergency department (ED).",
"This retrospective observational study compares the total hospital bed occupancy r... | Med/surg bed occupancy has a better correlation to extended transfer times, and occupancy over 92% at 5 AM in our institution corresponds to an increased frequency of extended transfer times from the ED. The process of ED evaluation, hospital admission, and subsequent transfer into the hospital are all complex processe... | yes |
19,561,828 | Is routine laboratory testing to evaluate for medical illness in psychiatric patients in the emergency department largely unrevealing? | {
"contexts": [
"This is a prospective study of psychiatric patients presenting to the emergency department (ED) to determine the value of routine laboratory studies used to attempt to exclude concomitant medical illness.",
"Physical exams and laboratory tests were performed on 375 psychiatric patients presen... | Patients presenting to the ED with psychiatric chief complaints, benign histories and normal physical exams have a low likelihood of clinically significant laboratory findings. | yes |
19,542,178 | Is copper-induced regression of cardiomyocyte hypertrophy associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway? | {
"contexts": [
"Vascular endothelial growth factor (VEGF) has been well documented to stimulate cell proliferation and differentiation; however, we have observed that copper (Cu)-induced regression of heart hypertrophy was VEGF-dependent. The present study was undertaken to test the hypothesis that Cu causes alt... | Enhanced VEGFR-1 signalling is involved in Cu regression of cardiomyocyte hypertrophy, and the PKG-1 pathway is likely associated with VEGFR-1. | yes |
19,543,984 | Does myocardial electrical activity affect myocardial electrical impedance measurements? | {
"contexts": [
"Myocardial electrical impedance (MEI) has shown to be an effective indicator of myocardial ischemia. We have previously developed a novel monitor for measuring MEI in near-real time. The object of this study was to test whether drug-induced changes in the frequency of the periodic myocardial elec... | These results demonstrate that our MEI monitor is unaffected by the frequency of the periodic myocardial electrical activity that generates the HR. | no |
19,540,515 | Is blood pressure elevated in children with primary snoring? | {
"contexts": [
"To compare ambulatory blood pressure (ABP) in nonoverweight, prepubertal children with and without primary snoring (PS), and to investigate whether PS is a part of the dose-response relationship between sleep-disordered breathing (SDB) and BP in children.",
"This was a cross-sectional communi... | PS was demonstrated to be an aspect of the dose-response relationship between SDB and BP in children and should not be considered completely benign. | yes |
19,545,209 | Does adult male circumcision reduce the risk of incident Neisseria gonorrhoeae , Chlamydia trachomatis , or Trichomonas vaginalis infection : results from a randomized , controlled trial in Kenya? | {
"contexts": [
"We examined the effect of male circumcision on the acquisition of 3 nonulcerative sexually transmitted infections (STIs).",
"We evaluated the incidence of STI among men aged 18-24 years enrolled in a randomized trial of circumcision to prevent human immunodeficiency virus (HIV) infection in K... | Circumcision of men in this population did not reduce their risk of acquiring these nonulcerative STIs. Improved STI control will require more-effective STI management, including partner treatment and behavioral risk reduction counseling. | no |
19,561,339 | Is cardiomyopathy associated with structural remodelling of heart valve extracellular matrix? | {
"contexts": [
"To increase the supply, many countries harvest allograft valves from explanted hearts of transplant recipients with ischaemic (ICM) or dilated cardiomyopathy (DCM). This study determines the structural integrity of valves from cardiomyopathic hearts.",
"Extracellular matrix (ECM) was examined... | Valves from cardiomyopathic hearts showed significant ECM deterioration with a disrupted collagen and elastic fibre network. It will be important to determine the impact of this ECM damage on valve durability and calcification in vivo if allografts are to be used from these donors. | yes |
19,553,877 | Does recent evidence support emotion-regulation interventions for improving health in at-risk and clinical populations? | {
"contexts": [
"The regulation of strong emotions has important implications for health, particularly among individuals with chronic illness. We focus this brief review on effective psychosocial interventions that emphasize and teach skills to improve emotion regulation in the context of health-related outcomes.... | Evidence generally supports the use of a variety of emotion-regulation interventions to improve health and well being in at-risk and clinical populations, although factors related to treatment response warrant additional research. | yes |
19,567,417 | Is release of developmental constraints on tetrad shape confirmed in inaperturate pollen of Potamogeton? | {
"contexts": [
"Microsporogenesis in monocots is often characterized by successive cytokinesis with centrifugal cell plate formation. Pollen grains in monocots are predominantly monosulcate, but variation occurs, including the lack of apertures. The aperture pattern can be determined by microsporogenesis feature... | The data support the view that there is a correlation between the inaperturate pollen production and the release of constraint on tetrad shape. However, in P. pusillus the tetrad shape may be constrained by a callose ring. It is also suggested that the lack of apertures in the pollen of Potamogeton may be due to the la... | yes |
19,568,424 | Does lactate dehydrogenase-elevating virus induce systemic lymphocyte activation via TLR7-dependent IFNalpha responses by plasmacytoid dendritic cells? | {
"contexts": [
"Lactate dehydrogenase-elevating virus (LDV) is a natural infectious agent of mice. Like several other viruses, LDV causes widespread and very rapid but transient activation of both B cells and T cells in lymphoid tissues and the blood. The mechanism of this activation has not been fully described... | Results indicate that LDV-induced activation of lymphocytes is due to recognition of LDV nucleic acid by TLR7 pattern recognition receptors in pDC's that respond with a lymphocyte-inducing IFNalpha response. | yes |
19,551,889 | Is yes-associated protein an independent prognostic marker in hepatocellular carcinoma? | {
"contexts": [
"Yes-associated protein (YAP), a downstream target of the Hippo signaling pathway, was recently linked to hepatocarcinogenesis in a mouse hepatocellular carcinoma (HCC) model. The objective of the current study was to investigate the clinical significance of YAP in HCC and its prognostic values in... | YAP is an independent prognostic marker for overall survival and disease-free survival times of HCC patients and clinicopathologically associated with tumor differentiation and serum AFP level. It is a potential therapeutic target for this aggressive malignancy. | yes |
19,546,267 | Does the Manchester Triage System provide good reliability in an Australian emergency department? | {
"contexts": [
"The Australasian Triage Scale is a simple five-point system of triage that forms the basis of triage in most emergency departments in Australia. The Manchester Triage System (MTS) is an algorithmic aid to the process of triage. It utilises a series of flow charts that lead the triage nurse to a l... | The MTS is a reliable system of triage in the emergency department. | yes |
19,540,403 | Does serial bedside B-type natriuretic peptide strongly predict prognosis in acute coronary syndrome independent of echocardiographic abnormalities? | {
"contexts": [
"Elevated levels of B-type natriuretic peptide (BNP) are associated with adverse clinical outcomes in acute coronary syndrome (ACS), but several questions remain outstanding. Firstly, it has not yet been determined whether an additional BNP sample at 7 weeks post ACS would enhance risk prediction.... | In ACS, bedside BNP levels predict CV events at 10 months, independent of many echocardiographic abnormalities including LVH. Furthermore, our study suggests that an additional 7 weeks post ACS BNP enhances risk stratification over and above a one-off high BNP at baseline. | yes |
19,539,913 | Do both host and graft vessels contribute to revascularization of xenografted human ovarian tissue in a murine model? | {
"contexts": [
"To characterize the human ovarian xenograft revascularization process.",
"Prospective experimental study.",
"Gynecology research unit in a university hospital.",
"Ovarian biopsies were obtained from 12 women aged 22-35 years.",
"Frozen-thawed human ovarian fragments were intraperi... | Host and graft vessels contributed sequentially to graft revascularization: murine angiogenesis initiated reperfusion from day 5 and, by day 10, human angiogenesis was shown to participate in graft revascularization. Host and graft angiogenesis are potential targets to reduce the avascular period after grafting. | yes |
19,545,451 | Do combined effects of obesity and type 2 diabetes contribute to increased breast cancer risk in premenopausal women? | {
"contexts": [
"Both obesity and type 2 diabetes are among the risk factors for breast cancer development. Combined effect of these metabolic abnormalities on breast cancer risk however, has not been examined in premenopausal women. We tested this association in type 2 diabetic women, categorized as obese, overw... | Obesity and type 2 diabetes, owing to their effects on adipocytokines and inflammatory mediators, contribute to increased breast cancer risk in premenopausal women. This study emphasizes healthy life style and better management of these metabolic disorders to avoid the pathogenesis of breast cancer and of other chronic... | yes |
26,543,339 | Is addition of rituximab associated with survival benefit compared with CHOP alone for patients with stage I diffuse large B-cell lymphoma? | {
"contexts": [
"The role of rituximab in combination with CHOP regimen in patients with stage I diffuse large B-cell lymphoma (DLBCL) remains to be defined. We aimed to compare CHOP plus rituximab (R-CHOP) with CHOP alone and determine the value of radiotherapy in these patients.",
"Between 2003 and 2009, 14... | CHOP alone could be as effective as R-CHOP regimen and additional radiotherapy would be necessary for stage I or stage I non-bulky DLBCL patients. | no |
26,546,562 | Is higher education associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity : results from the EIRA cohort and Swedish rheumatology register? | {
"contexts": [
"Whether low socioeconomic status (SES) is associated with worse rheumatoid arthritis (RA) outcomes in countries with general tax-financed healthcare systems (such as Sweden) remains to be elucidated. Our aim was to investigate the influence of educational background (achieving university/college ... | In Sweden, with tax-financed, generally accessible healthcare system, RA patients with a high education level experienced less pain and less functional disability. Further, these patients achieved pain remission more often during the first year receiving standard care. Importantly, education background affected neither... | yes |
26,539,255 | Does eGCG attenuate Uric Acid-Induced Inflammatory and Oxidative Stress Responses by Medicating the NOTCH Pathway? | {
"contexts": [
"The aim of this study is to investigate whether (-)-epigallocatechin-3-gallate (EGCG) can prevent the UA-induced inflammatory effect of human umbilical vein endothelial cells (HUVEC) and the involved mechanisms in vitro.",
"HUVEC were subjected to uric acid (UA) with or without EGCG treatment... | In summary, our findings indicated that Notch-1 plays an important role in the UA-induced inflammatory response, and the downregulation of Notch-1 by EGCG could be an effective approach to decrease inflammation and oxidative stress induced by UA. | yes |
26,539,253 | Is dNA-methylation in C1R a prognostic biomarker for acute myeloid leukemia? | {
"contexts": [
"Epigenetic aberrations play a central role in the pathophysiology of acute myeloid leukemia (AML). It has been shown that molecular signatures based on DNA-methylation (DNAm) patterns can be used for classification of the disease. In this study, we followed the hypothesis that DNAm at a single Cp... | Analysis of DNAm at C1R provides a simple, robust, and cost-effective biomarker to further complement risk assessment in AML. | yes |
26,553,031 | Is prediction of critical weight loss during radiation treatment in head and neck cancer patients dependent on BMI? | {
"contexts": [
"The aims of the present study were to explore pre-treatment predictors of weight loss during radiation treatment only in head and neck cancer (HNSCC) patients and investigate the weight loss in patients with or without a feeding tube.",
"Retrospectively, weight change during curative radiothe... | Pre-treatment BMI, tumor site and stage predicted weight loss above 5 % in HNSCC patients during radiotherapy. BMI should be considered when analyzing weight loss in HNSCC patients receiving curative radiotherapy. | yes |
26,548,949 | Does pRL-3 promote gastric cancer migration and invasion through a NF-κB-HIF-1α-miR-210 axis? | {
"contexts": [
"Phosphatase of regenerating liver-3 (PRL-3) has been implicated in controlling cancer cell invasiveness. Deregulated expression of PRL-3 is involved in cancer progression and predicts poor overall survival. Recent studies have revealed critical roles for microRNAs in various cellular processes, i... | PRL-3 regulates microRNA in gastric cancer. PRL-3 elevates hsa-miR-210 by upregulating HIF-1α. PRL-3 activates a NF-κB-HIF-1α-miR-210 axis by enhancing the phosphorylation of p65. PRL-3 promotes cell migration and invasion via the NF-κB-HIF-1α-miR-210 axis. High levels of PRL-3 and miR-210 are related with poor OS in g... | yes |
26,553,695 | Do calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease? | {
"contexts": [
"Calcific aortic valve stenosis (AS) is a life-threatening disease with no medical therapy. The genetic architecture of AS remains elusive. This study combines genome-wide association studies, gene expression, and expression quantitative trait loci mapping in human valve tissues to identify suscep... | This integrative genomic study confirmed the role of RUNX2 as a potential driver of AS and identified a new AS susceptibility gene, CACNA1C, belonging to the calcium signaling pathway. | yes |
26,549,734 | Does a Dipeptidyl Peptidase-4 Inhibitor but not Incretins suppress Abdominal Aortic Aneurysms in Angiotensin II-Infused Apolipoprotein E-Null Mice? | {
"contexts": [
"The main pathophysiology of abdominal aortic aneurysm (AAA) considerably overlaps with that of atherosclerosis. We reported that incretins [glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP)] or a dipeptidyl peptidase-4 inhibitor (DPP-4I) suppressed atheroscleros... | DPP-4I, MK0626, but not native incretins has protective effects against AAA in Ang II-infused Apoe－/－ mice via suppression of inflammation, proteolysis, and fibrosis in the aortic wall. | yes |
26,544,952 | Do lack of Acute Hand Care in the Southwest United States? | {
"contexts": [
"To describe the epidemiology of acute hand injuries and hand infections and to describe the factors associated with the transfer of these patients to a level 1 trauma center. In addition, we sought to understand management before transfer.",
"Retrospective review of patients with hand trauma ... | Patients transferred for acute hand care were young and male, and traveled an average 51 miles to get to our center. More than half of these patients were treated and discharged from our ED. This indicates that a majority may have been managed in a clinic setting. Most EDs in our region do not have a hand surgeon avail... | yes |
26,554,540 | Is nedd4L expression decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue? | {
"contexts": [
"Recent studies have demonstrated that the neural precursor cell expressed, developmentally downregulated 4-like (Nedd4L) gene plays a role in the progression of various cancers. However, reports describing Nedd4L expression in ovarian cancer tissues are limited.",
"A cohort (n = 117) of archi... | Nedd4L protein expression may be an independent prognostic marker of ovarian cancer development. | yes |
26,529,285 | Is osteopontin a proximal effector of leptin-mediated non-alcoholic steatohepatitis ( NASH ) fibrosis? | {
"contexts": [
"Liver fibrosis develops when hepatic stellate cells (HSC) are activated into collagen-producing myofibroblasts. In non-alcoholic steatohepatitis (NASH), the adipokine leptin is upregulated, and promotes liver fibrosis by directly activating HSC via the hedgehog pathway. We reported that hedgehog-... | OPN overexpression in NASH enhances leptin-mediated fibrogenesis via PI3K/Akt. OPN neutralization significantly reduces NASH fibrosis, reinforcing the potential utility of targeting OPN in the treatment of patients with advanced NASH. | yes |
26,538,215 | Does a20 suppress hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression? | {
"contexts": [
"Aberrant expression of A20 has been reported in several human malignancies including hepatocellular carcinoma (HCC). However, its clinical relevance and potential role in HCC remain unknown.",
"Quantitative PCR, Western blots and immunohistochemistry analyses were used to quantify A20 express... | Our results demonstrate that A20 plays a negative role in the development and progression of HCC probably through inhibiting Twist1 expression. A20 may serve as a novel prognostic biomarker and potential therapeutic target for HCC patients. | yes |
26,538,583 | Does endothelial β-Catenin Signaling be Required for Maintaining Adult Blood-Brain Barrier Integrity and Central Nervous System Homeostasis? | {
"contexts": [
"The blood-brain barrier (BBB) formed by brain endothelial cells interconnected by tight junctions is essential for the homeostasis of the central nervous system. Although studies have shown the importance of various signaling molecules in BBB formation during development, little is known about th... | These results demonstrate the prerequisite role of endothelial β-catenin in maintaining the integrity of adult BBB. The results suggest that BBB dysfunction secondary to defective β-catenin transcription activity is a key pathogenic factor in hemorrhagic stroke, seizure activity, and central nervous system inflammation... | yes |
26,527,425 | Is unplanned return to operating room after lower extremity arterial bypass an independent predictor for hospital readmission? | {
"contexts": [
"Hospital readmissions after surgical operations are considered serious complications and have an impact on health care-associated costs. The Centers for Medicare and Medicaid Services strongly encourage identification and ramification of factors associated with hospital readmissions after operati... | Readmission after lower extremity bypass surgery is a serious complication. Various factors put a patient at high risk for readmission. Return to the operating room, wound infection, amputation, deep venous thrombosis, and major reintervention on bypass are independent risk factors for hospital readmission. Return to t... | yes |
26,527,582 | Does aganglionosis with the absence of hypertrophied nerve fibres predict disease proximal to rectosigmoid colon? | {
"contexts": [
"The gold standard for the diagnosis of Hirschsprung's disease (HSCR) is the pathologic evaluation of a rectal biopsy that demonstrates the absence of ganglion cells and nerve fibre hypertrophy. However, it has been frequently reported that hypertrophic nerves may not be present in some variants l... | The absence of nerve fibre hypertrophy in the presence of aganglionosis on rectal biopsy specimens is predictive of long-segment HSCR. | yes |
26,546,017 | Does prevalence and correlate of Hazardous Drinking among Female Sex Workers in 13 Mexican Cities? | {
"contexts": [
"To describe the prevalence and correlates of hazardous drinking among female sex workers (FSWs) at 13 sites throughout Mexico.",
"FSWs (N = 1089) who were enrolled in a brief sexual risk reduction intervention (Mujer Segura) were queried about their sexual risk and substance use practices and... | Findings support the high prioritization by public health authorities of alcohol prevention and treatment programs for FSWs. | yes |
26,553,843 | Is twin vaginal delivery associated with lower umbilical arterial blood pH of the second twin and less intrapartum blood loss? | {
"contexts": [
"To clarify actual differences in the neonatal as well as maternal outcome between completed twin vaginal delivery and cesarean delivery.",
"We collected the data from women with a twin pregnancy who delivered two live fetuses between 1 January and 31 December 2014 at 20 teaching hospitals (1)... | Twin vaginal deliveries were associated with slightly but significantly lower UmA-pH of the second twin, whereas twin cesarean delivery was associated with significantly larger intrapartum blood loss. Not only the neonatal risk but also the maternal risk should be taken into account when an optimal delivery mode for th... | yes |
26,543,101 | Does microsomal Prostaglandin E Synthase-1-Derived PGE2 inhibit Vascular Smooth Muscle Cell Calcification? | {
"contexts": [
"Chronic administration of selective cyclooxygenase-2 (COX-2) inhibitors leads to an increased risk of adverse cardiovascular events, including myocardial infarction and stroke. Vascular smooth muscle cell (VSMC) calcification, a common complication of chronic kidney disease, is directly related t... | Our data revealed the pivotal role of COX-2-mPGES-1-PGE2 axis in vascular calcification. The selective inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure. | yes |
26,541,838 | Does [ MicroRNA-33a regulate the invasion of cervical cancer cells via targeting Twist1 ]? | {
"contexts": [
"To examine the expression of Twist1 in cervical cancer and to explore its biological function in the progression of cervical cancer.
",
"The expressions of Twist1 in 32 cervical cancers and matched normal tissues were examined by immunohistochemistry (IHC). Cell invasive ability and the expre... | Twist1 is critical for the invasiveness of cervical cancer cells; miR-33a, as a tumor suppressor gene, functions as an upstream regulator of Twist1 and is involved in the invasiveness of cervical cancer cell. | yes |
26,541,837 | Does [ MiRNA-381 inhibit the invasion of renal carcinoma and the underlying mechanisms ]? | {
"contexts": [
"To determine the inhibitory effect of miRNA-381 on renal carcinoma invasion and to explore the underlying mechanisms.
",
"After up-regulation of miRNA-381, the inhibitory effect of miR-381 on cell invasion was investigated. We screened the target genes of miRNA-381 in a database (starBase) th... | MiRNA-381 can inhibit cell invasion in renal cancer by block the function of CBP, β-catenin and LEF-1. | yes |
26,526,066 | Does deletion of aquaporin-4 in APP/PS1 mice exacerbate brain Aβ accumulation and memory deficits? | {
"contexts": [
"Preventing or reducing amyloid-beta (Aβ) accumulation in the brain is an important therapeutic strategy for Alzheimer's disease (AD). Recent studies showed that the water channel aquaporin-4 (AQP4) mediates soluble Aβ clearance from the brain parenchyma along the paravascular pathway. However the... | These results suggest that AQP4 attenuates Aβ pathogenesis despite its potentially inflammatory side-effects, thus serving as a promising target for treating AD. | yes |
26,539,667 | Does umbilical cord gene expression reveal the molecular architecture of the fetal inflammatory response in extremely preterm newborns? | {
"contexts": [
"The fetal inflammatory response (FIR) in placental membranes to an intrauterine infection often precedes premature birth raising neonatal mortality and morbidity. However, the precise molecular events behind FIR still remain largely unknown, and little has been investigated at gene expression lev... | The FIR expression signature in UC tissue contains molecular clues about signaling pathways that trigger FIR, and it is consistent with an acute inflammatory response by fetal innate and adaptive immune systems, which participate in the pathogenesis of neonatal brain damage. | yes |
26,540,658 | Does active Maintenance of the Gradient of Refractive Index be Required to Sustain the Optical Properties of the Lens? | {
"contexts": [
"To determine whether the cellular physiology of the lens actively maintains the optical properties of the lens and whether inhibition of lens transport affects overall visual quality.",
"One lens from a pair of bovine lenses was cultured in artificial aqueous humor (AAH), while the other was ... | The cellular physiology of the lens actively maintains its optical properties and inhibiting the Na/K/ATPase induces a myopic shift in vision similar to that observed clinically in patients who go on to develop cataract. | yes |
26,534,898 | Are higher levels of procoagulant microparticles in women with recurrent miscarriage associated with antiphospholipid antibodies? | {
"contexts": [
"Are the levels of circulating cell-derived microparticles (cMPs) in patients with recurrent miscarriage (RM) associated with the antiphospholipid syndrome (APS)?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Abortion, Habitual",
"Adult",
"Antibodies, Antiphospholipid",
"... | cMPs in women with RM are not associated with antiphospholipid antibodies (aPLs). | no |
26,545,946 | Is meis2 essential for cranial and cardiac neural crest development? | {
"contexts": [
"TALE-class homeodomain transcription factors Meis and Pbx play important roles in formation of the embryonic brain, eye, heart, cartilage or hematopoiesis. Loss-of-function studies of Pbx1, 2 and 3 and Meis1 documented specific functions in embryogenesis, however, functional studies of Meis2 in m... | Meis2-null mice are embryonic lethal. Our results reveal a critical role of Meis2 during cranial and cardiac neural crest cells development in mouse. | yes |
26,542,176 | Does endostatin exert radiosensitizing effect in non-small cell lung cancer cells by inhibiting VEGFR2 expression? | {
"contexts": [
"To determine the effects of endostatin on vascular growth factor receptor 2 (VEGFR2) expression in non-small cell lung cancer (NSCLC) cells and the mechanisms underlying its radiosensitizing effect.",
"VEGFR2 mRNA levels were determined in different NSCLC cell lines using qRT-PCR. RT-PCR and ... | Endostatin induces apoptosis and enhances radiosensitivity of the VEGFR2 high-expressing cell line Calu-1, but it has a limited effect on the VEGFR2 low-expressing cell line A549. | yes |
26,550,050 | Does software-Based Hybrid Perfusion SPECT/CT provide Diagnostic Accuracy When Other Pulmonary Embolism Imaging Is Indeterminate? | {
"contexts": [
"To investigate the diagnostic performance of perfusion single-photon emission computed tomography/computed tomography (Q-SPECT/CT) in patients suspected to have pulmonary embolism (PE) but with indeterminate computed tomographic pulmonary angiography (CTPA) or planar ventilation/perfusion (V/Q) s... | Q-SPECT/CT improves the diagnostic rate with promising accuracy in diagnosing PE that yields a satisfactory clinical verdict, especially when the CTPA and planar V/Q scan are indeterminate. | yes |
26,530,935 | Does impaired GLP-1 signaling contribute to reduced sensitivity to duodenal nutrients in obesity-prone rats during high-fat feeding? | {
"contexts": [
"Increased consumption of a high-fat (HF) diet is a salient contributor to obesity; however, how diminished satiation signaling contributes to overconsumption and obesity development remains poorly understood.",
"Using obese-prone (OP) and obese-resistant (OR) rats, we tested feeding responses... | Susceptibility to obesity coupled with HF feeding results in rapid impairments in nutrient-induced satiation through blunted responses in endogenous GLP-1 and hindbrain vagal afferent signaling. | yes |
26,550,269 | Does fasudil alleviate traumatic optic neuropathy by inhibiting Rho signaling pathway? | {
"contexts": [
"The present study is to investigate the pathological changes in rabbits with traumatic optic neuropathy (TON), as well as the effect of fasudil on the lesions.",
"A total of 144 New Zealand rabbits were successfully established as TON models. Twelve hours after surgery, the rabbits in control... | The present study demonstrates that fasudil inhibits the apoptosis of retinal ganglion cells and ameliorates damages of optic nerves in traumatic optic neuropathy. | yes |
26,542,058 | Does eRRα be a Marker of Tamoxifen Response and Survival in Triple-Negative Breast Cancer? | {
"contexts": [
"Estrogen-related receptor alpha (ERRα) signaling has recently been implicated in breast cancer. We investigated the clinical value of ERRα in randomized cohorts of tamoxifen-treated and adjuvant-untreated patients.",
"Cox proportional hazards regression was used to evaluate the significance o... | Taken together, these data show that ERRα expression predicts response to tamoxifen treatment, and ERRα could be a biomarker of tamoxifen sensitivity and a prognostic factor in TNBC. | yes |
26,541,225 | Does microRNA-340 mediate Metabolic Shift in Oral Squamous Cell Carcinoma by Targeting Glucose Transporter-1? | {
"contexts": [
"MicroRNA-340 (miR-340) is deregulated in many human cancers in correlation with tumor progression. Recent studies have found that microRNAs play key roles in energy metabolism. This study explored the contributions of miR-340 to the metabolic shift in oral squamous cell carcinoma (OSCC).",
"M... | The findings suggest that miR-340 might act as a molecular switch that contributes to the regulation of glycolysis in OSCC by regulating Glut1 expression. | yes |
26,550,183 | Does estrogen receptor α ( ESR1 ) IVS1-397T > C polymorphism lower risk of fracture? | {
"contexts": [
"Genetic factors are reported to affect fracture incidence. Many groups have explored the correlation of fracture risk with ESR1 IVS1-397T>C. The observed associations, however, are largely inconsistent. This meta-analysis of data from early-released studies was performed in an effort to determine... | The meta-analysis demonstrates that risk of fracture seems likely to be decreased due to IVS1-397 CC or CT genotype. | yes |
26,545,868 | Is willis-Ekbom disease associated with poor cardiovascular health in adults? | {
"contexts": [
"Willis-Ekbom disease (WED), also called restless legs syndrome (RLS), is a neurologic sensorimotor disease that may be associated with cardiovascular disease. Given high morbidity and mortality rates of cardiovascular disease worldwide, we assessed the relation between WED/RLS and cardiovascular ... | In adult Amerindians, although obesity and body mass index were associated with WED/RLS on univariate analyses, the association was not present after adjustment for confounders. No other significant associations were found between WED/RLS and AHA cardiovascular metrics. | no |
26,535,257 | Is idiopathic Cam Morphology Caused by Subclinical Slipped Capital Femoral Epiphysis : An MRI and CT Study? | {
"contexts": [
"Cam impingement as a known sequelae of slipped capital femoral epiphysis (SCFE) has led to speculation that subclinical SCFEs may be the causative factor in idiopathic cam morphology; alternatively, others have implicated an abnormal extension of the growth plate as a causative factor.",
"To ... | The proximal femoral growth plate normally has a posterior tilt that becomes more anterior through maturation. Idiopathic cam morphology has a drastically different growth plate tilt angle than cam morphology secondary to SCFE, suggesting that a majority of idiopathic cam morphology is not the result of subclinical SCF... | no |
26,529,096 | Does tNF accelerate Death of Mandibular Condyle Chondrocytes in Rats with Biomechanical Stimulation-Induced Temporomandibular Joint Disease? | {
"contexts": [
"To determine if temporomandibular joint chondrocyte apoptosis is induced in rats with dental biomechanical stimulation and what a role TNF takes.",
"Thirty-two rats were divided into 4 groups (n = 8/group) and exposed to incisor mal-occlusion induced by unilateral anterior crossbite biomechan... | Unilateral anterior crossbite stimulation induces mitochondrion-mediated apoptosis of articular chondrocytes. TNF accelerated the unilateral anterior crossbite induced chondrocytes apoptosis via death-receptor pathway. However, anti-TNF therapy does not prevent cartilage loss in this model of temporomandibular joint. | yes |
26,553,007 | Does g-8 indicate overall and quality-adjusted survival in older head and neck cancer patients treated with curative radiochemotherapy? | {
"contexts": [
"Evidence-based guidelines concerning the older head and neck cancer (HNCA) patient are lacking. Accurate patient selection for optimal care management is therefore challenging. We examined if geriatric assessment is indicative of long-term health-related quality of life (HRQOL) and overall surviv... | G-8 is indicative of quality-adjusted survival, and should be considered at time of treatment decisions for the older HNCA patient. | yes |
26,546,559 | Does an environmental route of exposure affect the formation of nanoparticle coronas in blood plasma? | {
"contexts": [
"Nanoparticles (NPs) in contact with biological fluids become covered by a tightly bound layer of proteins, the \"protein corona\", and it is largely accepted that this corona gives a new identity to NPs in biological milieu. We here consider the exposing scenario of NPs through an environmental r... | This work shows how a self-assembling protein, class II hydrophobin HFBII, with interesting biocompatible coating properties, strongly adsorbs on polystyrene NPs. HFBII is also shown to reduce aggregation of the NPs in human plasma which can increase their bioavailability with potential use in biomedical applications. ... | yes |
26,553,138 | Does combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kill cancer cells? | {
"contexts": [
"Our previous data demonstrated that targeting non-homologous end-joining repair (NHEJR) yields a higher radiosensitivity than targeting homologous recombination repair (HRR) to heavy ions using DNA repair gene knockouts (KO) in mouse embryonic fibroblast (MEF). In this study, we determined if com... | These results suggest that inhibitors targeting the NHEJR pathway could significantly enhance radiosensitivity of human cancer cells to C ion irradiation, rather than targeting the HRR pathway. | yes |
26,553,540 | Does microRNA profiling unveil hyperglycaemic memory in the diabetic heart? | {
"contexts": [
"Recent randomized trials suggest that intensive glycaemic control fails to reduce heart failure-related events in patients with diabetes. The molecular cues underlying persistent myocardial damage despite normoglycaemia restoration remain elusive. MicroRNAs (miRNAs), a class of small non-coding R... | Glycaemic control is not able to rescue hyperglycaemia-induced alterations of miRNA landscape in the diabetic heart. These findings may provide novel insights to understand why diabetic cardiomyopathy progresses despite normalization of blood glucose levels. | yes |
26,537,625 | Does tSG101 Silencing suppress Hepatocellular Carcinoma Cell Growth by Inducing Cell Cycle Arrest and Autophagic Cell Death? | {
"contexts": [
"The tumor susceptibility gene 101 (TSG101) was originally identified as a tumor-suppressor gene that mediates many molecular and biological processes, such as ubiquitination, endosomal trafficking, cell survival, and virus budding, but its role in hepatocellular carcinoma (HCC) is currently unkno... | TSG101 plays an important role in the development of HCC and may be a target for molecular therapy. | yes |
26,552,568 | Is concomitant lamotrigine use associated with decreased efficacy of the ketogenic diet in childhood refractory epilepsy? | {
"contexts": [
"Anti-epileptic drugs (AEDs) and the ketogenic diet (KD) are often used concomitantly in children with refractory epilepsy. It has been hypothesised that certain AEDs may interfere with KD. The purpose of this study was to elucidate relationships between efficacy of KD and use of specific AEDs.",
... | Lamotrigine treatment during KD is associated with a decreased efficacy of the KD. | yes |
26,539,962 | Do macrophages dictate the progression and manifestation of hypertensive heart disease? | {
"contexts": [
"Inflammation has been implicated in the initiation, progression and manifestation of hypertensive heart disease. We sought to determine the role of monocytes/macrophages in hypertension and pressure overload induced left ventricular (LV) remodeling.",
"We used two models of LV hypertrophy (LV... | Macrophages mediate the development of hypertension, LVH, adverse cardiac remodeling, and fibrosis. Macrophages, therefore, should be considered as a therapeutic target to reduce the adverse consequences of hypertensive heart disease. | yes |
26,538,206 | Are procedure Delays and Time of Day Associated With Reductions in Quality of Screening Colonoscopies? | {
"contexts": [
"There have been conflicting results from studies to determine whether factors unrelated to endoscopist skill, such as fatigue, affect the quality of screening colonoscopy. We studied the effects of human and system factors on screening colonoscopy withdrawal time and likelihood of detecting an ad... | Procedure delays and measured factors associated with fatigue, including time of day and multiple procedure blocks, do not reduce the odds of detecting an adenoma. Adenoma detection varies widely among providers, so efforts to improve adenoma detection should focus mainly on optimizing physician skill. | no |
26,537,746 | Do surgical management of damaged inferior alveolar nerve caused by endodontic overfilling of calcium hydroxide paste? | {
"contexts": [
"To evaluate the neurosensory outcome of management of damaged inferior alveolar nerves caused by endodontic overfilling and to assess the efficacy of delayed surgical intervention.",
"Nine patients who underwent surgical removal of extruded endodontic material were included. All patients were... | The results of this case series confirmed the notion that surgical management of the inferior alveolar nerve is effective in the treatment of nerve injuries caused by endodontic extrusion of calcium hydroxide paste. Delayed surgical repair of the inferior alveolar nerve can be indicated and helpful for the neurosensory... | yes |
26,548,541 | Is standards and guidelines for observational studies : quality in the eye of the beholder? | {
"contexts": [
"Patient care decisions demand high-quality research. To assist those decisions, numerous observational studies are being performed. Are the standards and guidelines to assess observational studies consistent and actionable? What policy considerations should be considered to ensure decision makers... | The lack of observational study standard/guideline agreement may contribute to variation in study conduct; disparities in what is considered credible research; and ultimately, what evidence is adopted. A common set of agreed on standards/guidelines for conducting observational studies will benefit funders, researchers,... | yes |
26,525,359 | Does isorhamnetin protect mice from lipopolysaccharide-induced acute lung injury via the inhibition of inflammatory responses? | {
"contexts": [
"Isorhamnetin (Isor), a 3-O-methylated metabolite of quercetin, has shown antioxidant and anti-proliferative effects in previous studies. In this study, we investigated the anti-inflammatory effect of Isor on LPS-induced acute lung injury (ALI). Accordingly, we evaluated the effect of Isor on cyto... | Isor showed efficient protective effects on an LPS-induced ALI model. MAPKs and NF-κB pathways are critical for Isor to perform its protective effects. | yes |
26,527,417 | Does the ileal bile acid transporter inhibitor A4250 decrease serum bile acids by interrupting the enterohepatic circulation? | {
"contexts": [
"Reabsorption of bile acids from the intestine by ileal bile acid transporter is pivotal for the enterohepatic circulation of BAs and sterol homoeostasis.",
"To assess tolerability and study, bile acid metabolism in a phase 1 trial with the selective ileal bile acid transporter inhibitor A4250... | A4250 is well tolerated. By blocking ileal bile acid transporter in the terminal ileum, it highly efficiently interrupts the enterohepatic circulation of BAs, and should be of benefit to patients with cholestatic liver diseases. Clinical Trial registration EudraCT 2013-001175-21. | yes |
26,526,641 | Is narrow band CE-Chirp auditory steady-state response more reliable than the conventional ASSR in predicting the behavioral hearing threshold? | {
"contexts": [
"We evaluated conventional ASSR (Bio-logic MASTER II) and NB CE-Chirp ASSR thresholds as objective hearing measures in both normal and hearing loss subjects.",
"Patients with sensorineural hearing loss and volunteer normal hearing subjects were enrolled. Pure tone thresholds at 0.5, 1, 2 and 4... | NB CE-Chirp ASSR generally revealed more favorable outcomes. However, its reliability was reduced at lower frequencies and in patients with milder hearing loss. | yes |
26,545,015 | Are infectious diseases associated with carotid intima media thickness in adolescence? | {
"contexts": [
"Inflammatory risk factors in childhood, e.g. obesity, impact on carotid artery intima media thickness (CIMT), an early indicator of atherosclerosis. Little is known on potential infectious origins in childhood. We investigated the association between number of reported different childhood infecti... | The SAPALDIA Youth study complements current evidence on infectious origins of atherosclerosis in adults. The larger effects observed in boys may relate to a higher vulnerability of the vasculature and/or to infectious pathogens. Our data are suggestive of an early impact of childhood infectious diseases on vascular he... | yes |
26,545,012 | Do apolipoprotein E-deficient rats develop atherosclerotic plaques in partially ligated carotid arteries? | {
"contexts": [
"The goal of this study was to establish an apolipoprotein E-deficient (ApoE(-/-)) rat model.",
"The ApoE(-/-) rat was created by TALEN-mediated gene targeting in the genetic background of Sprague Dawley rat. Six-to eight-week-old male rats were used in the experiments (n = 10 in each group)."... | The ApoE(-/-) rat is a novel model for dyslipidemia and could also be used in the research of atherosclerosis. | yes |
26,546,875 | Do dual inhibition of nuclear factor kappa-B and Mdm2 enhance the antitumor effect of radiation therapy for pancreatic cancer? | {
"contexts": [
"Radiation therapy, alone or in combination with chemotherapy, is effective for patients with locally advanced and recurrent pancreatic cancer. Ionizing radiation induces cell cycle arrest and cell apoptosis through enhancement several signals such as p53, p21(Waf1/Cip1), and caspase. However, the... | Combination therapy of radiation with nafamostat mesilate exerts enhanced anti-tumor effect against human pancreatic cancer. | yes |
26,528,352 | Does apelin-13 protect the heart against ischemia-reperfusion injury through the RISK-GSK-3β-mPTP pathway? | {
"contexts": [
"Apelin plays an important role in the protection against myocardial ischemia-reperfusion (I/R) injury, while the mechanism still remains unclear. In the current study, we aimed to evaluate the protective effect of apelin-13, and the main mechanism.",
"The in vivo I/R injury model (Sprague-Daw... | The protective mechanism of apelin-13 might be that inactivation of GSK-3β could inhibit the opening of mPTP by activating PI3K/Akt and ERK1/2 involved in the reperfusion injury salvage kinase (RISK) pathway. | yes |
26,547,123 | Do simultaneous multi-slice readout-segmented echo planar imaging for accelerated diffusion-weighted imaging of the breast? | {
"contexts": [
"Readout-segmented echo planar imaging (rs-EPI) significantly reduces susceptibility artifacts in diffusion-weighted imaging (DWI) of the breast compared to single-shot EPI but is limited by longer scan times. To compensate for this, we tested a new simultaneous multi-slice (SMS) acquisition for a... | SMS rs-EPI yields similar ADC values and SNR compared to conventional rs-EPI at markedly reduced scan time. Thus, SMS excitation increases the clinical applicability of rs-EPI for DWI of the breast. | yes |
26,542,590 | Does minimally Invasive Pancreaticoduodenectomy Improve Use or Time to Initiation of Adjuvant Chemotherapy for Patients With Pancreatic Adenocarcinoma? | {
"contexts": [
"The modifiable variable best proven to improve survival after resection of pancreatic adenocarcinoma is the addition of adjuvant chemotherapy. A theoretical advantage of minimally invasive pancreaticoduodenectomy (MI-PD) is the potential for greater use and earlier initiation of adjuvant therapy,... | At a national level, MI-PD does not result in greater use or earlier initiation of adjuvant chemotherapy. As surgeons and institutions continue to gain experience with this complex procedure, it will be important to revisit this benchmark as a justification for its increasing use for patients with pancreatic cancer. | no |
26,550,436 | Does notch-1 promote breast cancer cells proliferation by regulating LncRNA GAS5? | {
"contexts": [
"Notch signaling is indicated as novel therapeutic targets to prevent recurrence of breast cancer. LncRNAs were identified as downstream target of Notch pathway. However, the exact mechanisms involved in Notch signaling, lncRNAs and breast cancer remain to be explained.",
"This original resear... | Notch-1 promotes breast cancer cells proliferation by regulating LncRNA GAS5. | yes |
26,541,281 | Does steroid treatment resolve acute respiratory failure in patient transferred for ECMO? | {
"contexts": [
"Space-consuming mediastinal tumors can create respiratory failure.",
"We are reporting on a case of mediastinal lymphoma, which created respiratory failure in our patient. IV steroid therapy was used in our patient, who presented with end-stage respiratory failure.",
"Conservative managem... | In the right patient population, IV steroid treatment can avoid further deterioration of end-stage respiratory failure. | yes |
26,537,554 | Do term neonates with infection and shock display high cortisol precursors despite low levels of normal cortisol? | {
"contexts": [
"Neonatal therapy-resistant septic shock is a common problem in middle and low-income countries. We investigated whether newborn infants with infection and therapy-resistant hypotension showed evidence of abnormal levels of cortisol or cortisol precursors.",
"A total of 60 term or near term ne... | Septic newborn infants with therapy-resistant hypotension had very high DHEA levels, suggesting that 3-beta-hydroxysteroid dehydrogenase activity limited the rate of cortisol synthesis. | yes |
26,536,130 | Does aging be Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion? | {
"contexts": [
"Progressive loss of skeletal muscle mass with aging (sarcopenia) forms a global health concern. It has been suggested that an impaired capacity to increase muscle protein synthesis rates in response to protein intake is a key contributor to sarcopenia. We assessed whether differences in post-abso... | Aging is associated with the development of muscle anabolic inflexibility which represents a key physiological mechanism underpinning sarcopenia. | yes |
26,528,103 | Are polymorphisms of estrogen metabolism-related genes ESR1 , UGT2B17 , and UGT1A1 associated with osteoporosis in surgically menopausal Japanese women? | {
"contexts": [
"Bilateral salpingo-oophorectomy (BSO) is a risk factor for osteoporosis. Previous studies have reported an association between genetic polymorphisms and the risk of developing osteoporosis. However, the relationship between osteoporosis and genetic polymorphisms in Japanese women treated with BSO... | These results suggest that the ESR1, UGT2B17, and UGT1A1 polymorphisms are not genetic factors affecting osteoporosis in postmenopausal Japanese women. | no |
26,550,256 | Does up-regulation of serum miR-744 predict poor prognosis in patients with nasopharyngeal carcinoma? | {
"contexts": [
"MiRNAs has been shown to be implicated in the pathogenesis of many human diseases including cancer. Dysregulation of miR-744 is common in a number of cancers, indicating miR-774 might be closely correlated with the tumorigenesis process. However, the role and clinical significance of miR-774 in n... | Serum miR-744 was up-regulated in NPC patients. Higher expression level of serum miR-744 was closely correlated with was associated with poor prognosis in NPC and it might be employed as a potential biomarker for predicting the clinical outcome of NPC patients. | yes |
26,551,408 | Does resting-state functional network connectivity in prefrontal regions differ between unmedicated patients with bipolar and major depressive disorders? | {
"contexts": [
"Differentiating bipolar disorder (BD) from major depressive disorder (MDD) often poses a major clinical challenge, and optimal clinical care can be hindered by misdiagnoses. This study investigated the differences between BD and MDD in resting-state functional network connectivity (FNC) using a d... | As patients were unmedicated, the sample sizes were relatively small, although they were comparable to those in previous fMRI studies comparing BD and MDD. | yes |
26,538,111 | Does 2D cine DENSE with low encoding frequencies accurately quantify cardiac mechanics with improved image characteristics? | {
"contexts": [
"Displacement Encoding with Stimulated Echoes (DENSE) encodes displacement into the phase of the magnetic resonance signal. The encoding frequency (ke) maps the measured phase to tissue displacement while the strength of the encoding gradients affects image quality. 2D cine DENSE studies have used... | For 2D cine DENSE with through-plane dephasing, the encoding frequency can be lowered to 0.04 cycles/mm without compromising the quantification of twist or strain. The amount of wrapping can be reduced with this lower value to greatly simplify the input to unwrapping algorithms. The strain and twist results from studie... | yes |
26,538,117 | Does linc00152 promote proliferation in gastric cancer through the EGFR-dependent pathway? | {
"contexts": [
"Linc00152 has been identified highly associated with the tumorigenesis and development of gastric cancer, however, the detailed mechanism of Linc00152 involved still remains unclear.",
"RT-PCR and western blot were used to detect the expression of Linc00152 and EGFR. The CCK8 and EDU assay wa... | We first found that Linc00152 could promote tumor growth through EGFR-mediated PI3K/AKT pathway which may serve as potential targets for therapy in the future. | yes |
26,530,759 | Does novel Manganese-Porphyrin Superoxide Dismutase-Mimetic widen the Therapeutic Margin in a Preclinical Head and Neck Cancer Model? | {
"contexts": [
"To test the effects of a novel Mn porphyrin oxidative stress modifier, Mn(III) meso-tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin (MnBuOE), for its radioprotective and radiosensitizing properties in normal tissue versus tumor, respectively.",
"Murine oral mucosa and salivary glands were t... | MnBuOE widens the therapeutic margin by decreasing the dose of radiation required to control tumor, while increasing normal tissue resistance to RT-mediated injury. This is the first study to quantitatively demonstrate the magnitude of a single drug's ability to radioprotect normal tissue while radiosensitizing tumor. | yes |
26,554,234 | Are serum Gamma-Glutamyltransferase and Ferritin Related to Insulin Resistance : A Population-Based Study? | {
"contexts": [
"Recent studies have reported the association of gamma-glutamyltransferase (GGT) or ferritin with metabolic disorders. However, there has been no large population-based study assessing the interrelationship of these two biomarkers and their association with insulin resistance.",
"A population-... | Insulin resistance is associated with elevated serum GGT and ferritin. A combined determination of GGT and ferritin might lead to better predictions in patients with insulin resistance. | yes |
26,528,611 | Do [ Experience in the use of high-frequency selective percutaneous rhizotomy in trigeminal neuralgia associated with multiple sclerosis ]? | {
"contexts": [
"the study was aimed at assessment of the efficacy of percutaneous high frequency selective rhizotomy (PHFSR) after failure of conservative treatment of trigeminal neuralgia (TN) in multiple sclerosis (MS).",
"A retrospective analysis of 28 patients with TN associated with MS who underwent per... | These data confirm that PHFSR is a safe, repeatable, and effective method of symptomatic neurosurgical treatment of TN associated with MS and may be recommended in the case of failure/intolerance of medication. | yes |
26,553,199 | Does severe cranial neuropathies caused by fall from heights in children? | {
"contexts": [
"Falls from heights are the most common traumatic event associated with emergency department visits in children. This study investigated the incidence and clinical course of cranial neuropathies caused by falls from heights in children.",
"The computerized records of a tertiary pediatric medic... | Cranial neuropathies due to falls from heights are rare in children and are associated with high visual morbidity. Vision or ocular motility impairment, especially monocular vision loss, may be missed during acute intake to the emergency department, and a high index of suspicion is needed. Assessment of the pupillary r... | yes |
26,553,192 | Does med14 cooperate with brg1 in the differentiation of skeletogenic neural crest? | {
"contexts": [
"An intricate gene regulatory network drives neural crest migration and differentiation. How epigenetic regulators contribute to this process is just starting to be understood.",
"We found that mutation of med14 or brg1 in zebrafish embryos resulted in a cluster of neural crest cell-related de... | These results suggest a critical role for Mediator and BAF complex function in neural crest development, and may also clarify the nature of defects in some craniofacial abnormalities. | yes |
26,552,246 | Do [ Long-term follow-up study of titanium implant impact on pediatric mandibular growth and development ]? | {
"contexts": [
"To explore the impact of titanium implant on the growth and development of pediatric mandible after suffering from mandibular fracture and undergoing open reduction and internal fixation (ORIF) compared with those that underwent titanium plate removal postoperatively.",
"Fifteen pediatric pat... | The titanium plants have no significant impact on the growth and development of pediatric mandible postoperatively; hence, the question on whether the titanium plates should be removed or not may be neglected. The removal operation may lead to secondary trauma; thus, performing titanium plate removal routinely is not r... | yes |
26,553,587 | Does arjunolic acid protect against DNCB-induced atopic dermatitis-like symptoms in mice by restoring a normal cytokine balance? | {
"contexts": [
"Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying allergic inflammation. AD is triggered by oxidative stress and immune imbalance. The effect of oral arjunolic acid (AA) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in mice was inves... | The results indicate that AA suppresses DNCB-induced AD in mice via redox balance and immune modulation, and could be a safe clinical treatment for AD. | yes |
26,553,017 | Does n2 extenuate experimental ischemic stroke through platelet aggregation inhibition? | {
"contexts": [
"Thromboxane A2 (TXA2) can induce the platelet aggregation and lead to thrombosis. This will cause the low-reflow phenomenon after ischemic stroke and aggravate the damage of brain issues. Therefore, it is potential to develop the drugs inhibiting TXA2 pathway to treat cerebral ischemia.",
"Th... | N2 can improve the motor function, learning and memory ability in MCAO/R rats while reducing the infarct volume. N2 can inhibit TXA2 formation but promote PGI2, and can inhibit platelet aggregation induced by U46619 and ADP. Further, N2 inhibits thrombosis with a minor adverse effect of bleeding than Clopidogrel. In co... | yes |
26,541,061 | Is the differentially methylated region of MEG8 hypermethylated in patients with Temple syndrome? | {
"contexts": [
"To investigate the DNA-methylation levels in the newly described MEG8 differentially methylated region (DMR) in the imprinted cluster in 14q32 in patients with Temple syndrome.",
"We included three patients with Temple syndrome which were studied by Infinium HumanMethylation450 BeadChips, loc... | Based on the observed MEG8-DMR DNA-hypermethylation and previously published data, we conclude that DNA-methylation of the MEG3- and MEG8-DMR is functionally dependent on the DNA-methylation pattern of the IG-DMR. The observed combination of epimutations is predicted to be associated with bi-allelic MEG3 and MEG8 expre... | yes |
26,543,036 | Does catalase improve saccharification of lignocellulose by reducing lytic polysaccharide monooxygenase-associated enzyme inactivation? | {
"contexts": [
"Efficient enzymatic saccharification of plant cell wall material is key to industrial processing of agricultural and forestry waste such as straw and wood chips into fuels and chemicals.",
"Saccharification assays were performed on steam-pretreated wheat straw under ambient and O2-deprived en... | Oxidative inactivation of commercial cellulase mixtures is a significant factor influencing the overall saccharification efficiency and the addition of catalase can be used to protect these mixtures from inactivation. | yes |
26,526,322 | Does purpose in life predict allostatic load ten years later? | {
"contexts": [
"Living a purposeful life is associated with better mental and physical health, including longevity. Accumulating evidence shows that these associations might be explained by the association between life purpose and regulation of physiological systems involved in the stress response. The aim of th... | The current study provides the first empirical evidence for the long-term physiological correlates of life purpose and supports the hypothesis that self-health locus of control acts as one proximal psychological mechanism through which life purpose may be linked to positive biological outcomes. | yes |
26,538,066 | Do gene-expression patterns in peripheral blood classify familial breast cancer susceptibility? | {
"contexts": [
"Women with a family history of breast cancer face considerable uncertainty about whether to pursue standard screening, intensive screening, or prophylactic surgery. Accurate and individualized risk-estimation approaches may help these women make more informed decisions. Although highly penetrant ... | Together, these findings suggest that gene-expression levels in peripheral blood cells reflect genomic variation associated with breast cancer risk and that such data have potential to be used as a non-invasive biomarker for familial breast cancer risk. | yes |
26,525,737 | Is previous chronic cerebral infarction predictive for new cerebral ischemia after carotid endarterectomy? | {
"contexts": [
"The purpose of this study was to investigate the relation between preoperative chronic cerebral ischemia and postoperative new cerebral ischemia in patients undergoing carotid endarterectomy (CEA).",
"We reviewed the diffusion weighted magnetic resonance images (DWI) of the 51 patients (37 me... | The results of the present study suggest that preoperative chronic cerebral ischemia may aggravate postoperative newly developed cerebral ischemia in patients undergoing CEA. | yes |
26,545,365 | Does miR-362-5p promote the malignancy of chronic myelocytic leukaemia via down-regulation of GADD45α? | {
"contexts": [
"MicroRNAs (miR, miRNAs) play pivotal roles in numerous physiological and pathophysiological contexts. We investigated whether miR-362-5p act as an oncogene in chronic myeloid leukaemia (CML) and aimed to understand its potential underlying mechanisms.",
"We compared the miR-362-5p expression ... | miR-362-5p acts as an oncomiR that down-regulates GADD45α, which consequently activates the JNK1/2 and P38 signalling. This finding provides novel insights into CML leukaemogenesis and may help identify new diagnostic and therapeutic targets. | yes |
26,554,238 | Is rs219780 SNP of Claudin 14 Gene Related to Clinical Expression in Primary Hyperparathyroidism? | {
"contexts": [
"The CLDN14 gene encodes a protein involved in the regulation of paracellular permeability or ion transport at epithelial tight junctions as in the nephron. The C allele of the rs219780 SNP (single nucleotide polymorphism) of CLDN14 has been associated with renal lithiasis, high levels of parathor... | rs219780 SNP of CLDN14 does not appear to be a risk factor for the development of PHPT nor does it seem to influence the clinical expression of PHPT. | no |
26,554,236 | Is a Functional Single-Nucleotide Polymorphism in Pre-microRNA-196a2 Associated with Atrial Fibrillation in Han Chinese? | {
"contexts": [
"MicroRNAs are small, single-stranded, non-protein-coding RNAs of about 22 nucleotides. MicroRNA molecules have been identified to play key roles in a broad range of physiologic and pathologic processes. Polymorphisms in the corresponding sequence space are likely to make a significant contributio... | Our data support that the pre-miR-196a2 polymorphism is associated with AF, and the C allele is a risk factor for AF. | yes |
26,525,976 | Does first-Trimester Maternal Abdominal Adiposity predict Dysglycemia and Gestational Diabetes Mellitus in Midpregnancy? | {
"contexts": [
"This study assessed the association between first-trimester abdominal adiposity and dysglycemia and gestational diabetes mellitus (GDM) in midpregnancy.",
"In a prospective cohort of 485 women, we measured subcutaneous (SAT), visceral (VAT), and total (TAT) adipose tissue depth, using ultraso... | Elevated first-trimester VAT and TAT depth independently predicted the risk of dysglycemia later in pregnancy. | yes |
26,538,301 | Is neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins? | {
"contexts": [
"A hexanucleotide expansion in C9orf72 is the major genetic cause of inherited behavioural variant Frontotemporal dementia (bvFTD) and motor neurone disease (MND), although the pathological mechanism(s) underlying disease remains uncertain.",
"Using antibodies to poly-GA, poly-GP, poly-GR, pol... | Degeneration and loss of anterior horn cells associated with expansions in C9orf72 occurs in the absence of DPR, and implies that changes involving loss of nuclear staining for and a cytoplasmic aggregation of TDP-43 are more likely to be the cause of this. | yes |
26,537,870 | Is lamin A/C deficiency an independent risk factor for cervical cancer? | {
"contexts": [
"In the past, cervical cancer has been linked to Human Papilloma Virus (HPV) infection. Previously, we found that pre-neoplastic breast and ovarian lesions may be associated with lamin A/C deficiency, resulting in abnormal nuclear morphologies and chromosomal instability. Ultimately, these phenome... | Lamin A/C deficiency may serve as an independent risk factor for CIN development and as an indicator for preventive therapy in cervical cancer. | yes |
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