pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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26,537,085 | Does constitutive secretion of Interleukin-4 dictate CD133+ side population cells to resist drug treatment and cell death? | {
"contexts": [
"In the present study, we made an attempt to elucidate the role of oversecretion of interleukin-4 (IL-4) in cancer stem cells (CSCs) of head and neck squamous cell carcinoma (HNSCC).",
"HNSCC samples were analyzed for the presence of CSCs by flow cytometry. In addition, we have performed drug ... | Our data suggest that the autocrine secretion of IL-4 is a potential target for the development of novel anticancer drugs to prevent the CSCs-mediated therapy failure and tumorigenesis. | yes |
26,537,087 | Does prescription consisting of Vitamin C and Baicalin inhibit tumor growth by enhancing the antioxidant capacity in vivo? | {
"contexts": [
"To explore the antitumor effect of prescription consisting of Vitamin C (Vc) and Baicalin (PVB).",
"To explore the antitumor effect of PVB, using U14 cervical tumor-bearing mice model was used and the drugs were administrated through the gavages. Spectrophotometry was used to determine the co... | PVB shows better antitumor effect than Vc and baicalin used alone, and it can significantly enhance the immunity and antioxidant capacity of the mice. | yes |
26,541,743 | Is total laparoscopic resection for advanced gastric cancer safe and feasible in the Western population? | {
"contexts": [
"There is debate surrounding the use of laparoscopic resection for advanced gastric cancer in the Western population. Here we aim to assess the feasibility and short-term outcomes of laparoscopic gastrectomy in consecutive patients in a Western population.",
"From 2012 to 2014, retrospective r... | Following total laparoscopic resection for advanced gastric cancer, oncologic endpoints, postoperative course, and early cancer-specific follow-up are excellent. The results demonstrated here support the routine use of these techniques in the Western patient population. | yes |
26,542,462 | Does p38 MAPK mediate glial P2X7R-neuronal P2Y1R inhibitory control of P2X3R expression in dorsal root ganglion neurons? | {
"contexts": [
"We have previously shown that endogenously active purinergic P2X7 receptors (P2X7Rs) in satellite glial cells of dorsal root ganglia (DRGs) stimulate ATP release. The ATP activates P2Y1Rs located in the enwrapped neuronal somata, resulting in down-regulation of P2X3Rs. This P2X7R-P2Y1-P2X3R inhib... | p38 in DRG neurons downstream of P2Y1R is necessary and sufficient for the P2X7R-P2Y1R inhibitory control of P2X3R expression. | yes |
26,542,466 | Do tECPR2 mutations cause a new subtype of familial dysautonomia like hereditary sensory autonomic neuropathy with intellectual disability? | {
"contexts": [
"TECPR2 was first described as a disease causing gene when the c.3416delT frameshift mutation was found in five Jewish Bukharian patients with similar features. It was suggested to constitute a new subtype of complex hereditary spastic paraparesis (SPG49).",
"We report here 3 additional patien... | We suggest that the disease should therefore be classified as a new subtype of hereditary sensory-autonomic neuropathy. The discovery of additional mutations in non-Bukharian patients implies that this disease might be more common than previously appreciated and should therefore be considered in undiagnosed cases of in... | yes |
26,547,208 | Are early term infants at increased risk of requiring neonatal intensive care? | {
"contexts": [
"Increasing evidence is demonstrating that infants born early on during the term period are at increased risk of morbidity compared with infants born closer to a complete 40 week gestational pregnancy. The purpose of this study was to compare early term [gestation age (GA): 37-37 6/7 weeks] neonat... | Being born at early term is associated with increased risk of respiratory disease and hypoglycemia requiring neonatal intensive care. Further efforts directed at decreasing early term deliveries may be warranted. | yes |
26,553,336 | Does opioid Prescribing at Hospital Discharge contribute to Chronic Opioid Use? | {
"contexts": [
"Chronic opioid therapy for chronic pain treatment has increased. Hospital physicians, including hospitalists and medical/surgical resident physicians, care for many hospitalized patients, yet little is known about opioid prescribing at hospital discharge and future chronic opioid use.",
"We a... | Opioid receipt at hospital discharge among opioid naïve patients increased future chronic opioid use. Physicians should inform patients of this risk prior to prescribing opioids at discharge. | yes |
26,546,340 | Is abdominal radiography necessary in children with intussusception? | {
"contexts": [
"Children with intussusception require rapid and accurate diagnosis to enable timely intervention for satisfactory outcome. Ultrasonography is the recommended standard diagnostic modality; however, abdominal radiography (AR) is still used as an initial investigation. The aim of this study was to i... | AR is not recommended for the diagnosis of intussusception in children, for the prediction of the outcome of PRI or for the detection of occult pneumoperitoneum. AR should always be performed when clinical peritonism is present but is not otherwise necessary in children with suspected or confirmed intussusception. | no |
26,528,670 | Are symptoms of Depression Common in Patients With Idiopathic Normal Pressure Hydrocephalus : The INPH-CRasH Study? | {
"contexts": [
"If patients with idiopathic normal pressure hydrocephalus (INPH) also have depression, this could have important clinical ramifications in assessment and management of their cognitive function and response to shunting. In many dementias, depression is overrepresented, but the prevalence of depres... | Symptoms of depression are overrepresented in INPH patients compared with the population, despite treatment with a shunt. Screening for depression should be done in the evaluation of INPH patients in order to find and treat a coexisting depression. | yes |
26,546,710 | Do background differences in baseline and stimulated MMP levels influence abdominal aortic aneurysm susceptibility? | {
"contexts": [
"Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic bac... | These data demonstrate that 129/SvEv mice are more susceptible to AAA compared to C57Bl/6 mice. Intrinsic properties of the aorta between the two strains of mice, including baseline expression of MMP-2, influence susceptibility to AAA. | yes |
26,546,712 | Does uptake of Marasmius oreades agglutinin disrupt integrin-dependent cell adhesion? | {
"contexts": [
"Fruiting body lectins have been proposed to act as effector proteins in the defense of fungi against parasites and predators. The Marasmius oreades agglutinin (MOA) is a lectin from the fairy ring mushroom with specificity for Galα1-3Gal containing carbohydrates. This lectin is composed of an N-t... | Our results suggest a possible toxic mechanism of MOA, which consists of disturbing the cell adhesion and the cell viability. | yes |
26,543,299 | Does cD73 predict Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer? | {
"contexts": [
"CD73 is a membrane associated 5'-ectonucleotidase that has been proposed as prognostic biomarker in various solid tumors. The aim of this study is to evaluate CD73 expression in a cohort of patients with primary bladder cancer in regard to its association with clinicopathological features and dis... | High CD73 immunoreactivity was associated with favorable clinicopathological features. Furthermore, it predicts better outcome in the subgroup of pTa and pT1 tumors and may thus serve as additional tool for the selection of patients with favorable prognosis. | yes |
26,531,265 | Does high-pressure physiological saline isotonic solution administration enhance brain NGF and NGF-receptors expression? | {
"contexts": [
"Nerve growth factor (NGF) is a neurotrophin which promotes and regulates the survival of neurons in the peripheral nervous system. The aim of this study was to investigate the effect of high-pressure administration of sterile physiological saline isotonic solution (HpPSIS) into nasal cavity of la... | It was found that forced administration of HpPSIS enhances the presence of these neurotrophic signals, not only in the olfactory bulbs, but also in forebrain cholinergic neurons, which are known to degenerate as result of memory loss and brain aging, including Alzheimer Disease. These findings for the first time in the... | yes |
26,554,451 | Does mechanical fibrinogen-depletion support heparin-free mesenchymal stem cell propagation in human platelet lysate? | {
"contexts": [
"Pooled human platelet lysate (pHPL) is an efficient alternative to xenogenic supplements for ex vivo expansion of mesenchymal stem cells (MSCs) in clinical studies. Currently, porcine heparin is used in pHPL-supplemented medium to prevent clotting due to plasmatic coagulation factors. We therefor... | Here, we present an efficient, reproducible and economical method in compliance to good manufacturing practice for the preparation of MSC media avoiding xenogenic components and suitable for clinical studies. | yes |
26,543,059 | Is painful knee but not hand osteoarthritis an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women? | {
"contexts": [
"To assess whether joint pain or radiographic osteoarthritis (ROA) of the knee and hand is associated with all-cause and disease-specific mortality in middle-aged women.",
"Four subgroups from the prospective community-based Chingford Cohort Study were identified based on presence/absence of p... | We found a significantly increased risk of all-cause and CVD-specific mortality in women experiencing knee pain with or without ROA but not ROA alone. No relationship was found between hand OA and mortality risk. This suggests that knee pain, more than structural changes of OA is the main driver of excess mortality in ... | yes |
26,540,503 | Does alternaria induce Production of Thymic Stromal Lymphopoietin in Nasal Fibroblasts Through Toll-like Receptor 2? | {
"contexts": [
"Chronic rhinosinusitis with nasal polyps is a chronic inflammatory disease with markedly increased eosinophils, Th2-type lymphocytes, fibroblasts, and goblet cells. Fungi are commonly associated with airway inflammatory diseases, and thymic stromal lymphopoietin (TSLP) is important in the develop... | The results of this study show that TSLP expression could be induced in nasal fibroblasts by exposure to Alternaria and that TLR2 may be involved in the process. The promotion of TSLP production in nasal fibroblasts by airborne fungi may facilitate the development or exacerbation of Th2-type nasal inflammation, especia... | yes |
26,540,500 | Is the Interaction Between Prenatal Exposure to Home Renovation and Reactive Oxygen Species Genes in Cord Blood IgE Response Modified by Maternal Atopy? | {
"contexts": [
"Although home renovation exposure during childhood has been identified as a risk factor for the development of allergy, there is limited information on the association between prenatal exposure to home renovation and cord blood (CB) IgE response. The aims of this study were to identify the effect... | Maternal atopy modified the effect of prenatal exposure to home renovation on CB serum IgE response as well as the interaction between the exposure and neonatal genes involved in the oxidative stress pathway. These findings suggest that the genetically susceptible offspring of atopic mothers may be more vulnerable to t... | yes |
26,526,228 | Does neural Reactivity to Emotional Stimuli Prospectively predict the Impact of a Natural Disaster on Psychiatric Symptoms in Children? | {
"contexts": [
"Natural disasters expose entire communities to stress and trauma, leading to increased risk for psychiatric symptoms. Yet, the majority of exposed individuals are resilient, highlighting the importance of identifying underlying factors that contribute to outcomes.",
"The current study was par... | Results indicate that heightened neural reactivity and attention toward unpleasant information, as measured by the LPP, predispose children to psychiatric symptoms when exposed to higher levels of stress related to natural disasters, while greater reactivity to and processing of pleasant information may be a protective... | yes |
26,529,331 | Does hydrogen Sulfide alleviate Peritoneal Fibrosis via Attenuating Inflammation and TGF-β1 Synthesis? | {
"contexts": [
"Peritoneal fibrosis is one of the long-term complications in peritoneal dialysis (PD) patients. Recent evidences have suggested that hydrogen sulfide (H2S) is beneficial in treating various fibrotic diseases, including pulmonary fibrosis, cirrhosis, kidney fibrosis and cardiac hypertrophy. Howeve... | Exogenous H2S ameliorates the pathologic process of peritonitis via attenuating inflammatory events and TGF-β1 synthesis. These results suggest that H2S may be a potential therapy against peritoneal fibrosis during chronic PD. In the future, compounds releasing H2S at controlled rate will be assessed as potential candi... | yes |
26,552,238 | Does [ Programmed death ligand 1 negatively regulate inflammatory response of chronic periodontitis ]? | {
"contexts": [
"To investigate whether programmed death ligand 1 (PD-L1) expressed in the periodontal tissue of chronic periodontitis and the correlativity of PD-L1 and different degrees of chronic periodontitis, provide experience for immunoregulation mechanism, clinical treatment and prognosis of chronic perio... | The expression of PD-L1 in the periodontal tissue negativelv regulates inflammatory periodontal tissue damage. | yes |
26,537,893 | Does executive Functioning predict Academic But Not Social Adjustment to University? | {
"contexts": [
"Adjusting well academically and socially has been associated with enhanced academic performance and student retention. The purpose of this study was to examine subthreshold levels of ADHD symptoms such as inattention, hyperactivity, and executive functioning as potential predictors of academic an... | The BASC-College form may identify depression symptoms predictive of social adjustment, but symptoms of inattention or hyperactivity are not sufficiently sensitive to predict academic adjustment. Measures of executive function that include metacognition such as the BRIEF-A may be most promising in identifying skills pr... | yes |
26,535,230 | Is rotator Cuff Weakness a Risk Factor for First-Time Anterior Glenohumeral Instability? | {
"contexts": [
"Shoulder instability is a common problem in young athletes and can lead to pain and decreased ability to participate in high-level activities. Little is known about the modifiable risk factors for glenohumeral joint instability.",
"Isometric shoulder strength at baseline would be a modifiable... | No association was found between isometric shoulder strength measures at baseline and subsequent first-time anterior glenohumeral joint instability within the high-risk athletic population studied in this prospective cohort. | no |
26,536,571 | Does andrographolide attenuate LPS-Induced Cardiac Malfunctions Through Inhibition of IκB Phosphorylation and Apoptosis in Mice? | {
"contexts": [
"Cardiac malfunction is a common complication in sepsis and significantly increases the mortality of patients in septic shock. However, no studies have examined whether andrographolide (And) reduces LPS-induced myocardial malfunction.",
"Left ventricular systolic and diastolic functions were e... | And prevents LPS-induced cardiac malfunctions in mice by inhibiting TNF-α, IL-1β, and NO production, IκB phosphorylation, and cardiac apoptosis, indicating that And may be a potential agent for preventing myocardial malfunction during sepsis. | yes |
26,539,364 | Do hematoxylin and eosin stain shows a high sensitivity but sub-optimal specificity in demonstrating iron pigment in liver biopsies? | {
"contexts": [
"Perls' stain is routinely used to demonstrate iron in liver biopsies. We tested the hypothesis that it may be unnecessary in cases, where no iron or another similar pigment was seen on the routine hematoxylin and eosin (H and E) stained section.",
"The aim of this study was to evaluate the ef... | We demonstrate that the H and E stain is a sensitive method to detect iron pigment in liver biopsies, particularly when present in large quantities. A negative H and E stain might obviate the need for extra Perls' staining, thus saving costs and shortening report turn-around times. | yes |
26,538,092 | Is aIP1 a novel Agenet/Tudor domain protein from Arabidopsis that interacts with regulators of DNA replication , transcription and chromatin remodeling? | {
"contexts": [
"DNA replication and transcription are dynamic processes regulating plant development that are dependent on the chromatin accessibility. Proteins belonging to the Agenet/Tudor domain family are known as histone modification \"readers\" and classified as chromatin remodeling proteins. Histone modif... | AIP1 is a novel Agenet/Tudor domain protein in plants that could act as a link between DNA replication, transcription and chromatin remodeling during flower development. | yes |
26,554,585 | Does a Naturally Occurring rev1-vpu Fusion Gene Confer a Fitness Advantage to HIV-1? | {
"contexts": [
"Pandemic strains of HIV-1 (group M) encode a total of nine structural (gag, pol, env), regulatory (rev, tat) and accessory (vif, vpr, vpu, nef) genes. However, some subtype A and C viruses exhibit an unusual gene arrangement in which the first exon of rev (rev1) and the vpu gene are placed in the... | Expression of a rev1-vpu fusion gene does not affect regular Rev and Vpu functions or alter HIV-1 replication in primary target cells. Since there is no evidence for increased replication fitness of rev1-vpu encoding viruses, this polymorphism likely emerged in the context of other mutations within and/or outside the r... | no |
26,549,840 | Does multiple Intercostal Space Electrocardiogram allow Accurate Localization of Outflow Tract Ventricular Arrhythmia Origin? | {
"contexts": [
"Multiple intercostal recordings were supposed to get a more comprehensive view of the depolarization vector of the outflow tract ventricular arrhythmia (OT-VA), which may help to identify the OT-VA more accurately. This study was undertaken to develop a more accurate electrocardiogram (ECG) crite... | The combined TZ index outperformed other ECG criteria to differentiate left from right OT-VA origins. | yes |
26,536,615 | Does exenatide facilitate Recovery from Oxaliplatin-Induced Peripheral Neuropathy in Rats? | {
"contexts": [
"Oxaliplatin has widely been used as a key drug in the treatment of colorectal cancer; however, it causes peripheral neuropathy. Exenatide, a glucagon-like peptide-1 (GLP-1) agonist, is an incretin mimetic secreted from ileal L cells, which is clinically used to treat type 2 diabetes mellitus. GLP... | These results suggest that exenatide may be useful for treating peripheral neuropathy induced by oxaliplatin in colorectal cancer patients with type 2 diabetes. | yes |
26,526,964 | Are high homocysteine , low vitamin B-6 , and increased oxidative stress independently associated with the risk of chronic kidney disease? | {
"contexts": [
"Hyperhomocysteinemia, increased oxidative stress, and decreased antioxidant defense function have been found to be associated with the risk of chronic kidney disease (CKD). Deficiencies of folate and vitamin B-6 (pyridoxal 5'-phosphate, PLP) may cause hyperhomocysteinemia and increased oxidative ... | High homocysteine, low PLP, increased oxidative stress, and decreased antioxidant enzyme activity (superoxide dismutase activity) were independent contributing factors in the development of early stage CKD. | yes |
26,549,219 | Does dNA Methylation of MMP9 be Associated with High Levels of MMP-9 Messenger RNA in Periapical Inflammatory Lesions? | {
"contexts": [
"Matrix metalloproteinases (MMPs) are the major class of enzymes responsible for degradation of extracellular matrix components and participate in the pathogenesis of periapical inflammatory lesions. MMP expression may be regulated by DNA methylation. The purpose of the present investigation was t... | The present study suggests that the unmethylated status of the MMP9 gene in periapical lesions may explain the observed up-regulation of messenger RNA transcription in these lesions. | yes |
26,543,603 | Does miR-132 inhibit lung cancer cell migration and invasion by targeting SOX4? | {
"contexts": [
"Multiple MicroRNAs (miRNAs) have been identified in the development and progression of lung cancer. However, the expression and roles of miR-132 in non-small cell lung cancer (NSCLC) remain largely undefined. The aim of this study is to investigate the biological functions and its molecular mecha... | Our finding provides new insight into the mechanism of NSCLC progression. Therapeutically, miR-132 may serve as a potential target in the treatment of human lung cancer. | yes |
26,543,604 | Is miR-1290 a potential prognostic biomarker in non-small cell lung cancer? | {
"contexts": [
"miR-1290 is a newly discovered microRNA (miRNA), and its role in non-small cell lung cancer (NSCLC) remains unknown. This study aimed to evaluate the expression levels of miR-1290 in NSCLC tissues and serum, and explore its associations with clinicopathological characteristics and prognosis of NS... | Our study suggests that miR-1290 is overexpressed in NSCLC, and serum miR-1290 may be used as a potential prognostic biomarker for NSCLC. | yes |
26,542,751 | Are functional polymorphisms in the gene encoding macrophage migration inhibitory factor ( MIF ) associated with active pulmonary tuberculosis? | {
"contexts": [
"The role of the cytokine, macrophage migration inhibition factor (MIF) was assessed in tuberculosis. This case-control study investigated whether commonly occurring functional MIF polymorphisms are associated with active tuberculosis as well as with serum levels of MIF, IFN-γ and TNF-α.",
"Tw... | These data suggested a distinct genetic and immunopathogenic basis for tuberculosis at the MIF locus. Serum MIF, IFN-γ and TNF-α profiles distinguish tuberculosis from the more inflammatory phenotype and may play a role in pathogenesis and as biomarkers of active tuberculosis. | yes |
26,553,068 | Does autophagy contribute to the chemo-resistance of non-small cell lung cancer in hypoxic conditions? | {
"contexts": [
"The development of chemo-resistance in non-small lung cancer is a major obstacle in treating patients. Hypoxia is a commonly faced microenvironment in solid tumor and suggested to be related to both autophagy and chemo-resistance.",
"In this study, we investigated the role of hypoxia-induced ... | Autophagy may play an important role in acquiring resistance to chemotherapy in lung cancer and hypoxia related pathway seems to be involved in autophagy induction. | yes |
26,527,378 | Do mapping areas of spatial-temporal overlap from wildlife tracking data? | {
"contexts": [
"The study of inter-individual interactions (often termed spatial-temporal interactions, or dynamic interactions) from remote tracking data has focused primarily on identifying the presence of such interactions. New datasets and methods offer opportunity to answer more nuanced questions, such as w... | The value of the jPPA approach within current wildlife habitat analysis workflows is highlighted along with its simple and straightforward implementation and interpretation. Given the current emphasis on remote tracking in wildlife movement and habitat research, new approaches capable of leveraging both the spatial and... | yes |
26,545,730 | Are serum caspase-3 levels and mortality associated in patients with severe traumatic brain injury? | {
"contexts": [
"Different apoptosis pathways activate caspase-3. In a study involving 27 patients with traumatic brain injury (TBI), higher caspase-3 levels were found in contusion brain tissue resected from non-survivors than from survivors. The objective of this study was to determine whether there is an assoc... | The association between serum caspase-3 levels and mortality in TBI patients was the major novel finding of our study. | yes |
26,526,700 | Are iCMJE authorship criteria met in a substantial proportion of manuscripts submitted to Biochemia Medica? | {
"contexts": [
"Our aim was to investigate if: (a) authors of Biochemia Medica meet authorship criteria given by International Committee of Medical Journal Editors (ICMJE), (b) authorship violations are more frequent in submissions containing some type of scientific misconduct.",
"Self-reported authorship co... | Large proportion of authors of the manuscripts submitted to Biochemia Medica do not fulfil ICMJE criteria. Violation of authorship criteria is not more common for manuscripts with some type of scientific misconduct. | no |
26,546,127 | Do divergent growth strategies between red algae and kelps influence biomechanical properties? | {
"contexts": [
"Morphology and material properties are the main components of the mechanical design of organisms, with species groups developing different optimization strategies in the context of their physical environment. For intertidal and subtidal seaweeds, possessing highly flexible and extensible tissues ... | We propose that divergent patterns in the distribution of material properties along blades may have different consequences for the performance of kelps and red algae. The positioning of younger tissues at the blade base for kelps may enable these species to attain larger body sizes in wave-swept habitats. | yes |
26,552,743 | Is lower-normal TSH associated with better metabolic risk factors : A cross-sectional study on Spanish men? | {
"contexts": [
"Subclinical thyroid conditions, defined by normal thyroxin (T4) but abnormal thyroid-stimulating hormone (TSH) levels, may be associated with cardiovascular and metabolic risk. More recently, TSH levels within the normal range have been suggested to be associated with metabolic syndrome and cardi... | TSH and free T4 within the normal range are associated with the metabolic syndrome. The sample half-below the TSH median (with probably higher functional thyroid status) exhibited better metabolic and cardiovascular profiles. | yes |
26,531,054 | Does poor self-rated health predict mortality in patients with stable chronic heart failure? | {
"contexts": [
"In heart failure, a holistic approach incorporating the patient's perspective is vital for prognosis and treatment. Self-rated health has strong associations with adverse events and short-term mortality risk, but long-term data are limited. We investigated the predictive value of two consecutive ... | Poor self-rated health predicts mortality in our long-term follow-up of patients with stable chronic heart failure, even after adjustment for established risk predictors. We encourage clinicians to capture patient-reported self-rated health routinely as an easy to assess, clinically meaningful measure and pay extra att... | yes |
26,550,819 | Does disordered eating behavior and mental health correlate among treatment seeking obese women? | {
"contexts": [
"Previous research has suggest that obesity is associated with increased risk for psychopathological disorders, however, little is known about which obese patients are most vulnerable to psychopathological disorders. We therefore investigated 126 treatment-seeking obese women to describe eating di... | Findings corroborate earlier work indicating that psychological distress is elevated in obese treatment seeking, bolstering the need for mental health assessment of such individuals. The feeling of ineffectiveness constitutes the major predictor of psychopathological aspects. This is an important result which may infor... | yes |
26,536,363 | Is a male preponderance in patients with Indian post kala-azar dermal leishmaniasis associated with increased circulating levels of testosterone? | {
"contexts": [
"Post kala-azar dermal leishmaniasis (PKDL) is a neglected parasitic disease that occurs after apparent cure from visceral leishmaniasis (VL) and poses a challenge for elimination of VL, being its proposed reservoir. Several epidemiological studies have proposed that sex hormones may account for t... | Taken together, our study has established a male dominance in PKDL, which showed a strong association with testosterone. This information should be taken into consideration for disease monitoring and control. | yes |
26,547,514 | Does ankaferd blood stopper enhance healing after osseous grafting in patients with intrabony periodontal defects? | {
"contexts": [
"The aim of this clinical study were to compare the clinical efficacy of ankaferd blood stopper (ABS) when used in combination with autogenous cortical bone graft (ACB) in the treatment of intrabony periodontal defects.",
"The study was planned as a split-mouth design. Fifteen patients with ch... | The findings suggest that ABS enhances the soft tissue healing during the periodontal defect fill by the ACB by stimulating angiogenesis and vascular endothelial cell function, prevents GR and thereby increases the clinical attachment gain. | yes |
26,548,631 | Does transamniotic stem cell therapy ( TRASCET ) mitigate bowel damage in a model of gastroschisis? | {
"contexts": [
"We sought to determine whether intraamniotic delivery of concentrated amniotic-derived mesenchymal stem cells (afMSCs) could reduce damage to exposed bowel in experimental gastroschisis.",
"Rat fetuses (n=117) with surgically created gastroschisis were divided into three groups: untreated ani... | Amniotic mesenchymal stem cells mitigate bowel damage in experimental gastroschisis after concentrated intraamniotic injection. Transamniotic stem cell therapy (TRASCET) may become a practical component of the treatment of gastroschisis. | yes |
26,528,344 | Does treatment of subclinical hypothyroidism affect bone mass as determined by dual-energy X-ray absorptiometry , peripheral quantitative computed tomography and quantitative bone ultrasound in Spanish women? | {
"contexts": [
"The results of studies examining the influence of subclinical hypothyroidism (SCH) and levothyroxine (L-T4) replacement therapy on bone have generated considerable interest but also controversy. The present research aims to evaluate the effects of L-T4 treatment on different skeletal sites in wom... | Our results indicate that adequate metabolic control through replacement treatment with L-T4 in pre- and postmenopausal women does not affect bone mass. | no |
26,552,836 | Is co-morbid personality disorder in early intervention psychosis clients associated with greater key worker emotional involvement? | {
"contexts": [
"Co-morbid personality disorder (PD) is associated with poorer outcomes in psychosis patients, but it is not known whether these patterns are present at illness onset. This study investigated the prevalence of co-morbid PD in clients of an Early Intervention in Psychosis Service (EIPS) and compare... | Co-morbid PD is common in EIPS patients. The EIPS model is both assertive and intensive; although this appears to be effective in preventing hospital admissions, this does not equip professionals to manage the higher emotional burden associated with a co-morbid PD diagnosis. | yes |
26,551,082 | Is cDX2 downregulation associated with poor differentiation and MMR deficiency in colon cancer? | {
"contexts": [
"Homeobox genes are often deregulated in cancer and can have both oncogenic and tumor-suppressing potential. The Caudal-related homeobox transcription factor 2 (CDX2) is an intestine-specific transcription factor. CDX2 has been implicated in differentiation, proliferation, cell adhesion, and migra... | We found that CDX2 downregulation is associated with MMR deficiency, right-sided tumors, and poor differentiation at both the mRNA and protein level. Whether CDX2 plays an active role in tumor progression in MSI/MMR-deficient tumors remains to be elucidated. | yes |
26,537,115 | Does fibroblast growth factor 8 regulate postnatal development of paraventricular nucleus neuroendocrine cells? | {
"contexts": [
"Fibroblast growth factors (FGFs) are crucial signaling molecules that direct the development of the vertebrate brain. FGF8 gene signaling in particular, may be important for the development of the hypothalamus-pituitary-adrenal (HPA)-axis. Indeed, newborn Fgf8 hypomorphic mice harbor a major redu... | First, Fgf8 hypomorphy did not eliminate VP and CRH neurons in the mouse PVN, but rather disrupted the postnatal timing of neuropeptide expression onset in PVN neurons. Second, Fgf8 hypomorphy may, in part, be an explanation for affective disorders involving hyperactivity of the HPA axis, such as anxiety. | yes |
26,537,114 | Do inferior vena cava diameters and collapsibility index reveal early volume depletion in a blood donor model? | {
"contexts": [
"Changes of volume status can be readily inferred from variations in diameter of the inferior vena cava (IVC) measured by ultrasound. However the effect of IVC changes following acute blood loss are not fully established. In this study, three different approaches to measuring IVC variables were co... | IVC diameter and collapsibility index variations, as measured in M mode, consistently detect volume changes after blood donation. The longitudinal mid-hepatic approach performed better by allowing a panoramic view, avoiding anatomical aberrancies at fixed points and permitting to identify the best possible perpendicula... | yes |
26,541,651 | Does targeting protein arginine methyltransferase 5 inhibit human hepatocellular carcinoma growth via the downregulation of beta-catenin? | {
"contexts": [
"Protein arginine methyltransferase 5 (PRMT5), a type II PRMT, is highly expressed in some tumors, but its role in hepatocellular carcinoma (HCC) is still unknown.",
"PRMT5 level in HCC specimens was determined by immunohistochemical staining and the association with clinicopathologic features... | PRMT5 plays an important role in HCC. PRMT5 may be a promising target for HCC therapy. | yes |
26,551,326 | Does trinitrotoluene induce Endoplasmic Reticulum Stress and Apoptosis in HePG2 Cells? | {
"contexts": [
"This study aims to describe trinitrotoluene (TNT)-induced endoplasmic reticulum stress (ERS) and apoptosis in HePG2 cells.",
"HePG2 cells were cultured in vitro with 0, 6, 12, or 24 μg/ml TNT solution for 12, 24, and 48 h. Western blotting was performed to detect intracellular ERS-related pro... | TNT could increase the expression levels of GRP78, GRP94, Caspase-4, and CHOP in HePG2 cells; this increase in protein expression might be involved in HePG2 apoptosis through the induction of the ERS pathway. | yes |
26,540,401 | Does interleukin-17A be Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome? | {
"contexts": [
"Interleukin-17A is a proinflammatory cytokine known to play a role in host defense and pathologic inflammation in murine models of lung injury. The relationship between interleukin-17A and inflammation in human lung injury is unknown. Our primary objective was to determine whether interleukin-17A... | Elevated circulating and alveolar levels of interleukin-17A are associated with increased percentage of alveolar neutrophils, alveolar permeability, and organ dysfunction in acute respiratory distress syndrome. | yes |
26,542,478 | Does resveratrol relieve gestational diabetes mellitus in mice through activating AMPK? | {
"contexts": [
"Gestational diabetes mellitus (GDM) is a disease often manifests in mid to late pregnancy with symptoms including hyperglycemia, insulin resistance and fetal mal-development. The C57BL/KsJ-Lep (db/+) (db/+) mouse is a genetic GDM model that closely mimicked human GDM symptoms. Resveratrol (RV) is... | Our findings further supported the potential therapeutic effect of RV on not only diabetes, but also alleviating GDM. | yes |
26,549,336 | Does rush immunotherapy for wasp venom allergy seem safe and effective in patients with mastocytosis? | {
"contexts": [
"Patients with mastocytosis and wasp venom allergy (WA) may benefit from venom immunotherapy (VIT). However, fatal insect sting reactions have been described in mastocytosis patients despite previous immunotherapy. We investigated the safety and efficacy of (rush) VIT in patients with mastocytosis... | VIT is safe in cutaneous mastocytosis patients with WA, while caution has to be made in case of systemic mastocytosis. VIT was effective in the patients who were re-stung. | yes |
26,546,374 | Does low-Level Vagus Nerve Stimulation attenuate Myocardial Ischemic Reperfusion Injury by Antioxidative Stress and Antiapoptosis Reactions in Canines? | {
"contexts": [
"Low-level vagus nerve stimulation (LL-VNS) has been demonstrated to protect myocardium against acute ischemia/reperfusion (I/R) injury. However, the underlying mechanism of this protective effect remains unknown.",
"This study aimed to test the hypothesis that LL-VNS exerts cardioprotective e... | LL-VNS exerts protective effects on myocardial I/R injury. Its potential mechanisms involve the suppression of oxidative stress and cellular apoptosis. | yes |
26,548,745 | Is bone marrow involvement rare in superficial gastric mucosa-associated lymphoid tissue lymphoma? | {
"contexts": [
"The initial staging work-up of gastric mucosa-associated lymphoid tissue (MALT) lymphoma includes bone marrow examination. Since gastric MALT lymphoma is mostly detected in early stages with the national cancer screening programme in Korea, bone marrow is rarely involved.",
"To investigate th... | Bone marrow involvement was rare in patients with only superficial gastric MALT lymphoma without extragastric invasion. Further studies are warranted to identify the risk factors of bone marrow involvement in gastric MALT lymphoma. | yes |
26,536,055 | Does next-Generation Sequencing of Matched Primary and Metastatic Rectal Adenocarcinomas demonstrate Minimal Mutation Gain and Concordance to Colonic Adenocarcinomas? | {
"contexts": [
"-Colorectal carcinoma is the third most common cause of cancer death in males and females in the United States. Rectal adenocarcinoma can have distinct therapeutic and surgical management from colonic adenocarcinoma owing to its location and anatomic considerations.",
"-To determine the oncol... | -The somatic mutations identified in our rectal adenocarcinoma cohort showed a strong correlation to those previously characterized in colonic adenocarcinoma. In addition, most rectal adenocarcinomas harbored identical somatic mutations in both the primary tumor and metastasis. These findings demonstrate evidence that ... | yes |
26,531,279 | Does new probing and warm-wash-out technique improve early patency rates in arteriovenous fistula surgery? | {
"contexts": [
"Arteriovenous fistulas (AVFs) are commonly used during hemodialysis. Early failure of AVFs is quite common with incidence of 43% to 63%. In this study we aimed to describe a novel approach to AVF surgery for improving early patency rates.",
"Patients were divided into two groups according to ... | Probing and warm-wash out technique will simply increase the surgical success and flow rate of draining vein. | yes |
26,545,983 | Are dNA methylation subgroups in melanoma associated with proliferative and immunological processes? | {
"contexts": [
"DNA methylation at CpG dinucleotides is modified in tumorigenesis with potential impact on transcriptional activity.",
"We used the Illumina 450 K platform to evaluate DNA methylation patterns of 50 metastatic melanoma tumors, with matched gene expression data.",
"We identified three diff... | Melanoma consists of divergent methylation groups that are distinguished by promoter methylation, proliferation and content of immunological cells. | yes |
26,531,709 | Does horizontal Slide create Less Cervical Motion When Centering an Injured Patient on a Spine Board? | {
"contexts": [
"A patient with a suspected cervical spine injury may be at risk for secondary neurologic injury when initially placed and repositioned to the center of the spine board.",
"We sought to determine which centering adjustment best limits cervical spine movement and minimizes the chance for second... | Of the three adjustments, our team found that horizontal slide was also easier to complete than the other methods. The horizontal slide best limited cervical spine motion and may be the most helpful for minimizing secondary injury based on the study findings. | yes |
26,541,263 | Is serum dipeptidyl peptidase-4 associated with multiple vertebral fractures in type 2 diabetes mellitus? | {
"contexts": [
"Patients with type 2 diabetes mellitus (T2DM) have a high risk of fracture although they have slightly higher bone mineral density (BMD). There is no evidence that dipeptidyl peptidase-4 (DPP-4) is involved in the bone fragility of the patients. The aim of this study was to investigate the associ... | We firstly showed that high level of serum DPP-4 is associated with prevalent multiple VFs independently of BMD and bone formation in men with T2DM. | yes |
26,526,232 | Are gender differences in scalp hair growth rates maintained but reduced in pattern hair loss compared to controls? | {
"contexts": [
"Hair loss is related to follicular density, programmed regrowth and hair productivity.",
"The dissatisfaction with hair growth in patients experiencing hair loss might be due to slower linear hair growth rate (LHGR).",
"LHGR and hair diameter was evaluated in Caucasian controls and patien... | Caucasian ethnicity. | yes |
26,540,149 | Does neuromuscular Blocking Agent Cisatracurium attenuate Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1? | {
"contexts": [
"Neuromuscular blocking agents (NMBAs) bind the nicotinic acetylcholine receptor α1 (nAChRα1) that also contributes to inflammatory signaling. Thus, the author hypothesized that the use of NMBA mitigates lung injury by improving ventilator synchrony and decreasing inflammatory responses.",
"Lu... | The use of NMBA is lung protective through its antiinflammatory properties by blocking the nAChRα1. | yes |
26,546,412 | Does bone morphogenetic protein 7 sensitize O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide? | {
"contexts": [
"Temozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase (MGMT) in tumor tissue. Here we used MGMT-expressing glioblastoma stem cells (GSC) lines... | These data support the view that reduced endogenous BMP7 expression/signaling in GSC may contribute to maintained stemness, EMT, and chemoresistant phenotype, suggesting that BMP7 treatment may provide a novel strategy in combination with TMZ for an effective treatment of glioblastoma exhibiting unmethylated MGMT. | yes |
26,546,411 | Is p21 deficiency susceptible to osteoarthritis through STAT3 phosphorylation? | {
"contexts": [
"Osteoarthritis (OA) is a multifactorial disease, and recent studies have suggested that cell cycle-related proteins play a role in OA pathology. p21 was initially identified as a potent inhibitor of cell cycle progression. However, it has been proposed that p21 is a regulator of transcription fac... | The lack of p21 has catabolic effects by regulation of aggrecan and MMP-13 expression through STAT3 phosphorylation in the cartilage tissue. p21 may function as a regulator of transcriptional factors other than the inhibitor of cell cycle progression in the cartilage tissue. Thus, the regulation of p21 may be a therape... | yes |
26,550,135 | Does herbal compound Naoshuantong capsule attenuate retinal injury in ischemia/reperfusion rat model by inhibiting apoptosis? | {
"contexts": [
"Ischemic ophthalmopathy threatens people's lives and health. The herbal compound medication, Naoshuantong capsule, plays a critical role in the treatment of cardiac-cerebral vascular diseases; however, the roles and mechanisms of action of Naoshuantong capsule in ischemic ophthalmopathy is unknow... | Our study indicated that Naoshuantong capsule attenuates retinal damage in rat models of ischemic ophthalmopathy, possibly by inhibiting apoptosis. | yes |
26,537,248 | Does tLE6 mutation cause the earliest known human embryonic lethality? | {
"contexts": [
"Embryonic lethality is a recognized phenotypic expression of individual gene mutations in model organisms. However, identifying embryonic lethal genes in humans is challenging, especially when the phenotype is manifested at the preimplantation stage.",
"In an ongoing effort to exploit the hig... | In this first report of a human defect in a member of the subcortical maternal subcritical maternal complex, we show that the TLE6 mutation is gender-specific and leads to the earliest known human embryonic lethality phenotype. | yes |
26,541,007 | Does atrial electrogram interpretation improve after an innovative education program? | {
"contexts": [
"To avoid adverse patient outcomes from inappropriate treatment, it is recommended that an atrial electrogram (AEG) be recorded whenever atrial arrhythmias develop in patients after cardiac surgery. However, AEGs are not commonly performed because nurses lack knowledge about differentiating atrial... | Accurate interpretation of AEGs is an easy skill for specialized critical care nurses to learn via an online education program. | yes |
26,547,591 | Does cFTR potentiator therapy ameliorate impaired insulin secretion in CF patients with a gating mutation? | {
"contexts": [
"To investigate the effect of treatment with ivacaftor on insulin secretion in patients with cystic fibrosis (CF) (ΔF508\\S549R) having CFRD/impaired insulin secretion.",
"A standard OGTT was performed before and after 16weeks of treatment with ivacaftor in 2 sibling patients with CF carrying ... | The treatment with ivacaftor in patients with CF carrying gating mutation can ameliorate impaired insulin secretion. Further studies and larger cohorts are needed to evaluate the impact of ivacaftor on insulin secretion in patients with CF carrying gating or other mutations. | yes |
26,547,330 | Does [ Methylglyoxal inhibit human umbilical vein cell migration in vitro by down-regulating integrinβ3 ]? | {
"contexts": [
"To explore the effects of methylglyoxal on endothelia cell migration.",
"Human umbilical vein endothelial cells (HUVECs) were stimulated by serial concentrations of methylglyoxal (MGO, 0, 25, 50, 100 and 200 µmol/L) for 24 h, and the cell migration was assessed by scratch wound and Transwell ... | Methylglyoxal inhibits HUVEC migration in vitro by down-regulating integrin β3 expression. | yes |
26,554,252 | Is cYP2C9 Genetic Polymorphism a Potential Predictive Marker for the Efficacy of Rosuvastatin Therapy? | {
"contexts": [
"There is well-known inter-individual variability in the cholesterol-lowering effect of statins. However, inter-individual variability in response to rosuvastatin treatment in subjects with hypercholesterolemia has not been clearly established. This study aimed to evaluate the associations of CYP2... | This study suggests that the CYP2C9 polymorphism may be involved in the lipid-lowering efficacy of rosuvastatin in patients with hyperlipidemia. | yes |
26,554,254 | Is downregulation of MicroRNA-1 Associated with Poor Prognosis in Hepatocellular Carcinoma? | {
"contexts": [
"The relationship between microRNA-1 (miR-1) expression and prognosis has not been reported in hepatocellular carcinoma (HCC). The present study aimed to explore the clinicopathological significance and the prognostic role of miR-1 in HCC.",
"The expression levels of miR-1 were quantified usin... | Low miR-1 expression is associated with shortened survival time. MiR-1 may act as a potential prognostic biomarker for HCC patients. | yes |
26,528,509 | Do cold snare piecemeal resection of colonic and duodenal polyps ≥1 cm? | {
"contexts": [
"Endoscopic removal of duodenal and colorectal adenomas is currently considered to be the standard of care for prevention of adenocarcinoma. The use of cautery carries a risk of delayed bleeding, post-polypectomy syndrome, and perforation. We examined the safety and feasibility of removing colonic... | Cold snare polypectomy for large duodenal and colonic polyps is technically feasible and may have a favorable safety profile compared to standard electrocautery-based endoscopic resection. Comparative trials are required to determine the relative safety and efficacy of cold snare techniques for complete and durable res... | yes |
26,525,812 | Do [ What do the doctors of different specialties know about sleep disorders and their treatment ]? | {
"contexts": [
"To assessdoctor's knowledge on the relevance of the problem of sleep disorders, methods of their diagnosis and treatment.",
"The survey was conducted among90physicians of different the rapeuticspecialties of Kazan medical institutions.",
"The doctors believe that main causes of sleep diso... | Physicians are not well informed about the problems of sleep disorders, have a small idea of the methods of sleepresearch and drugs for their treatment as well as of a sequence of operations that should be used to resolve this problem. | yes |
26,538,247 | Is visceral adiposity associated with altered myocardial glucose uptake measured by ( 18 ) FDG-PET in 346 subjects with normal glucose tolerance , prediabetes , and type 2 diabetes? | {
"contexts": [
"The heart requires constant sources of energy mostly from free fatty acids (FFA) and glucose. The alteration in myocardial substrate metabolism occurs in the heart of diabetic patients, but its specific association with other metabolic variables remains unclear. We aimed to evaluate glucose uptak... | Our findings indicate visceral adiposity is strongly associated with the alteration of myocardial glucose uptake evaluated by (18)FDG-PET, and its association further relates to T2DM. | yes |
26,550,140 | Do aqueous extracts of Fructus Ligustri Lucide induce gastric carcinoma cell apoptosis and G2/M cycle arrest? | {
"contexts": [
"Previous studies have shown that Fructus Ligustri Lucide (FLL) can be used to anti-cancer. However, the mechanism by which FLL mediate this effect is unclear. In the present study, aqueous extracts of FLL induced cell apoptosis in human gastric carcinoma cell was investigated.",
"The cell via... | These results confirmed that FLL could induce apoptosis in human gastric carcinoma, the underlying molecular mechanisms, at least partially, through activation p21/p53 and suppression CDC2/cdc25C signaling in vitro. | yes |
26,525,994 | Is proactive Semantic Interference Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders : A Preliminary Study? | {
"contexts": [
"To evaluate the relationship between susceptibility to proactive semantic interference (PSI) and retroactive semantic interference (RSI) and brain amyloid load in non-demented elders.",
"27 participants (11 cognitively normal [CN] with subjective memory complaints, 8 CN without memory complai... | In non-demented individuals, vulnerability to PSI was highly associated with total and regional beta-amyloid load and may be an early cognitive marker of brain pathology. | yes |
26,552,444 | Do experimental evaluation of sand fly collection and storage methods for the isolation and molecular detection of Phlebotomus-borne viruses? | {
"contexts": [
"Several viruses have been recently isolated from Mediterranean phlebotomine sand flies; some are known to cause human disease while some are new to science. To monitor the Phlebotomus-borne viruses spreading, field studies are in progress using different sand fly collection and storage methods. T... | While the collection and storage methods investigated had not much impact on the ability to detect viral RNA by molecular methods, they affected the capacity to recover viable viruses. Consequently, sand fly collection and handling procedures should be established in advance depending on the goal of the surveillance st... | yes |
26,552,447 | Does high glucose induce renal tubular epithelial injury via Sirt1/NF-kappaB/microR-29/Keap1 signal pathway? | {
"contexts": [
"Diabetic nephropathy (DN) is a serious complication that commonly confronted by diabetic patients. A common theory for the pathogenesis of this renal dysfunction in diabetes is cell injury, inflammation as well as oxidative stress. In this content, the detailed molecular mechanism underlying high... | High glucose induces renal tubular epithelial injury via Sirt1/NF-κB/microR-29/Keap1 signal pathway. | yes |
26,537,913 | Is horizontal gene transfer in bdelloid rotifers ancient , ongoing and more frequent in species from desiccating habitats? | {
"contexts": [
"Although prevalent in prokaryotes, horizontal gene transfer (HGT) is rarer in multicellular eukaryotes. Bdelloid rotifers are microscopic animals that contain a higher proportion of horizontally transferred, non-metazoan genes in their genomes than typical of animals. It has been hypothesized tha... | Nearly half of foreign genes were acquired before the divergence of bdelloid families over 60 Mya. Nonetheless, HGT is ongoing in bdelloids and has contributed to putative functional differences among species. Variation among our study species is consistent with the hypothesis that desiccating habitats promote HGT. | yes |
26,528,957 | Does low-Dose Docetaxel Combined with Dexamethasone be Feasible for Patients with Castration-Resistant Prostate Cancer? | {
"contexts": [
"Docetaxel-based chemotherapy against castration-resistant prostate cancer (CRPC) has recently been shown to be effective and tolerable. The objective of this study was to retrospectively evaluate the efficacy and toxicity of low-dose docetaxel in combination with dexamethasone.",
"Thirty-seve... | Low-dose docetaxel in combination with dexamethasone is feasible in Japanese CRPC patients. Hematological toxicity is less than that seen with standard docetaxel therapy, but it is necessary to monitor patients for severe nonhematological toxicities, particularly very elderly patients. | yes |
26,528,955 | Does the profile of platelet α-granule released molecules affect postoperative liver regeneration? | {
"contexts": [
"Platelets promote liver regeneration through site-specific serotonin release from dense granules, triggering proliferative signaling in hepatocytes. However, the effects of factors derived from platelet α-granules on liver regeneration are unclear, because α-granules contain bioactive molecules w... | The postoperative profile of circulating platelet-derived factors correlates with the ability of the remnant liver to regenerate. Portal venous pressure and intrahepatic endothelial dysfunction might account for the selective granule release profile. Selective modulation of platelet α-granule release in patients may re... | yes |
26,538,618 | Do large-volume low apparent diffusion coefficient lesions predict poor survival in bevacizumab-treated glioblastoma patients? | {
"contexts": [
"Glioblastomas treated with bevacizumab may develop low-signal apparent diffusion coefficient (low-ADC) lesions, which may reflect increased tumor cellularity or atypical necrosis. The purpose of this study was to examine the relationship between low-ADC lesions and overall survival (OS). We hypot... | The volume of low-ADC lesions at the second post-bevacizumab scan predicted shorter OS. This suggests that low-ADC lesions may be considered important imaging markers and included in treatment decision algorithms. | yes |
26,534,878 | Are glut-1 intensity and pattern of expression in thymic epithelial tumors predictive of WHO subtypes? | {
"contexts": [
"Glucose-transporter-1 (Glut-1) may be a useful marker for differentiating B3 thymomas and thymic carcinomas. Since the literature is limited, we undertook a study to evaluate its diagnostic value in a series of thymic epithelial tumors.",
"Glut-1 expression was studied by the group of patholo... | Glut-1 expression globally depended on histological subtypes and the staining patterns (diffuse or zonal) were different between thymic carcinomas and type B3 thymomas. A comparative study of Glut-1 expression in atypical versus conventional type A thymomas appears warranted. Otherwise, restriction to epithelial cells ... | yes |
26,542,945 | Does eIF2A-dependent translational arrest protect leukemia cells from the energetic stress induced by NAMPT inhibition? | {
"contexts": [
"Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD(+) biosynthesis from nicotinamide, is one of the major factors regulating cancer cells metabolism and is considered a promising target for treating cancer. The prototypical NAMPT inhibitor FK866 effectively lowers NAD... | We identified EIF2A phosphorylation as a novel early molecular event occurring in response to NAMPT inhibition and mediating protein synthesis arrest. In addition, our data suggest that tumors exhibiting an impaired LBK1- AMPK- EIF2A response may be especially susceptible to NAMPT inhibitors and thus become an elective... | yes |
26,534,750 | Does evaluation of anxiety levels and factors associated with positive test result in patients with drug hypersensitivity? | {
"contexts": [
"High anxiety has been reported in patients with drug hypersensitivity reaction (DHR); however, its relationship with the test results was not studied previously.",
"We aimed to investigate the association of patient anxiety with the results of drug tests together with the other contributing f... | Patients with DHR have high levels of anxiety; however, this is not related to the results of drug tests. Because panic reaction symptoms may accompany the objective symptoms of DHR, a complete clinical work-up is required before deciding whether the reaction is related to panic or a "true DHR." | yes |
26,541,579 | Do validation of Duruöz Hand Index in patients with tetraplegia? | {
"contexts": [
"Cross-sectional, clinical measurement.",
"To investigate the validity of the Duruöz Hand Index (DHI) in the assessment of hand function in patients with tetraplegia.",
"A total of 40 patients with tetraplegia participated. Patients' upper extremities were assessed on the level of 'body fu... | The DHI was found a valid method in the assessment of hand functions in patients with tetraplegia. | yes |
26,525,360 | Does diazoxide protect L6 skeletal myoblasts from H2O2-induced apoptosis via the phosphatidylinositol-3 kinase/Akt pathway? | {
"contexts": [
"Transplanted cell survival might greatly improve the therapeutic efficacy of cell therapy. Diazoxide (DZ), a highly selective mitochondrial ATP-sensitive potassium channel opener, is known to suppress cell apoptosis and protect cells in oxidative stressed ischemic environment. We explored the mec... | These data suggest that DZ pre-treatment contributes to protection of L6 SKMs against apoptosis at least partly by activating the PI3K/Akt pathway and subsequently inhibiting the mitochondrial-mediated caspase-dependent apoptotic signalling pathway. | yes |
26,546,094 | Is dopamine Administration a Risk Factor for Delirium in Patients Undergoing Coronary Artery Bypass Surgery? | {
"contexts": [
"Delirium is an important morbidity following heart surgery. We sought to determine whether dopamine infusion is associated with increased risk of delirium in patients undergoing coronary artery bypass grafting.",
"A total of 137 patients (mean age; 61.02±7.83, 105 males) were included in the ... | Along with older age, dopamine infusion--even in low doses but more probably in higher doses--emerged as an independent risk factor for delirium in patients undergoing CABG. Further study is needed to confirm the validity of results presented. | yes |
26,535,766 | Does novel PPARγ Modulator GED-0507-34 Levo ameliorate Inflammation-driven Intestinal Fibrosis? | {
"contexts": [
"Intestinal fibrosis is mainly associated with Crohn's disease and is defined as a progressive and excessive deposition of extracellular matrix components. No specific antifibrotic therapies are available. In this study, we evaluate the antifibrotic effect of a novel 5-ASA analog able to activate ... | GED ameliorates intestinal fibrosis in dextran sulfate sodium-induced chronic colitis in mice and regulates major profibrotic cellular and molecular mechanisms. | yes |
26,527,749 | Does flightless I Homolog repress Prostate Cancer Progression through Targeting Androgen Receptor Signaling? | {
"contexts": [
"Flightless I (FLII), member of the gelsolin superfamily of actin-remodeling proteins, functions as a transcriptional coregulator. We aim to evaluate a tumor-suppressive function of FLII in regulating androgen receptor (AR) in prostate cancer progression.",
"We examined FLII protein and mRNA e... | FLII plays a tumor-suppressive role and serves as a crucial determinant of resistance of prostate cancer to endocrine therapies. | yes |
26,527,748 | Does a 13 mer LNA-i-miR-221 Inhibitor restore Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells? | {
"contexts": [
"The onset of drug resistance is a major cause of treatment failure in multiple myeloma. Although increasing evidence is defining the role of miRNAs in mediating drug resistance, their potential activity as drug-sensitizing agents has not yet been investigated in multiple myeloma.",
"Here we s... | Taken together, our findings provide the proof of concept that LNA-i-miR-221 can reverse melphalan resistance in preclinical models of multiple myeloma, providing the framework for clinical trials to overcome drug resistance, and improve patient outcome in multiple myeloma. | yes |
26,524,462 | Are cXCL4 Plasma Levels Associated with the Extent of Coronary Artery Disease or with Coronary Plaque Morphology? | {
"contexts": [
"CXCL4 is a platelet chemokine released at micromolar concentrations upon platelet activation. CXCL4 has been shown to promote atherogenesis by various mechanisms. However, data on CXCL4 plasma levels in patients with coronary artery disease are largely inconclusive. Computed coronary artery angio... | While CXCL4 may be present and active within the arterial wall, local increase of CXCL4 may not translate into systemically elevated CXCL4 levels. Further studies will have to test whether CXCL4 may still represent a suitable therapeutic target in human atherosclerosis. | no |
26,544,174 | Does micronutrient Deficiency Independently predict Adverse Health Outcomes in Patients With Heart Failure? | {
"contexts": [
"Despite growing evidence on the important role of micronutrients in prognosis of heart failure (HF), there has been limited research that micronutrient deficiency predicts health outcomes in patients with HF.",
"The aim of this study was to determine whether micronutrient deficiency independe... | These findings show that micronutrient deficiency independently predicted poor HRQoL and earlier cardiac event-free survival in patients with HF. Further research is needed to provide for specific dietary guidelines for better health outcomes in HF patients. | yes |
26,545,220 | Does axillary Lymph Node Dissection be a Risk Factor for Major Complications After Immediate Breast Reconstruction? | {
"contexts": [
"Complications after immediate breast reconstruction pose a significant challenge to the reconstructive surgeon. Known risk factors include smoking, obesity, age, and adjuvant oncologic therapies. Less is known about the association between axillary lymph node dissection (ALND) and the development... | Mastectomy with ALND is associated with a 3-fold increase in risk of major complications in women undergoing immediate breast reconstruction, even after adjustment for known risk factors and confounders. Further studies are warranted to elucidate how ALND leads to these complications and what measures can reduce their ... | yes |
26,542,793 | Does sT depression in lead aVL differentiate inferior ST-elevation myocardial infarction from pericarditis? | {
"contexts": [
"ST-segment elevation (STE) due to inferior STE myocardial infarction (STEMI) may be misdiagnosed as pericarditis. Conversely, this less life-threatening etiology of ST elevation may be confused for inferior STEMI. We sought to determine if the presence of any ST-segment depression in lead aVL wou... | When there is inferior ST-segment elevation, the presence of any ST depression in lead aVL is highly sensitive for coronary occlusion in inferior myocardial infarction and very specific for differentiating inferior myocardial infarction from pericarditis. | yes |
26,535,122 | Does occult H. pylori infection partially explain 'false-positive ' results of ( 13 ) C-urea breath test? | {
"contexts": [
"In a previous study, UBiT-100 mg, (Otsuka, Spain), a commercial (13)C-urea breath test omitting citric acid pre-treatment, had a high rate of false-positive results; however, it is possible that UBiT detected low-density 'occult' infection missed by other routine reference tests. We aimed to vali... | UBiT suffers from a high rate of false-positive results and sub-optimal specificity, and the protocol skipping citric acid pre-treatment should be revised; however, low-density 'occult' H. pylori infection that was undetectable by conventional tests accounted for around 25% of the 'false-positive' results. | yes |
26,544,507 | Does co-Transplantation of Skin-Derived Precursors and Collagen Sponge facilitate Diabetic Wound Healing by Promoting Local Vascular Regeneration? | {
"contexts": [
"Impaired diabetes wound healing can often lead to serious complications and remains a major health concern due to the lack of effective therapeutic approaches. Compromised angiogenesis, disrupted growth factor and cytokine activity are all attributable to diabetic wound healing impairment. The sk... | Accelerated wound healing and enhanced local capillary regeneration could be observed 14 days after skin ablation from both SKPs and collagen sponge co-transplanted and collagen sponge only groups. Subsequent analyses further revealed superior pro-angiogenic effects from the SKP and collagen sponge co-delivered group, ... | yes |
26,535,407 | Do a Profilometric Study to Assess the Role of Toothbrush and Toothpaste in Abrasion Process? | {
"contexts": [
"Despite of many studies conducted on toothbrushes and toothpaste to find out the culprit for abrasion, there is no clear cut evidence to pin point the real cause for abrasion.",
"An in vitro assessment of the role of different types of toothbrushes (soft/ medium/hard) in abrasion process when... | Besides supporting the fact that toothpaste is needed to create a significant abrasion, this study also showed that a softer toothbrush can cause more abrasion than harder ones. The flexibility of bristles is only secondary to abrasion process and abrasivity of dentifrice has an important role in abrasion process. | yes |
26,534,751 | Are anxiety but not depression symptoms associated with greater perceived dyspnea in asthma during bronchoconstriction? | {
"contexts": [
"To determine whether anxiety and depression are associated with greater respiratory discomfort in asthma.",
"Adults with asthma (n = 230) underwent methacholine (Mch) challenge. Anxiety and depression, asthma control, and quality of life were evaluated at study entry by using the Hospital Anx... | Anxiety but not depression was associated with greater perceived dyspnea intensity but not other measures of respiratory discomfort in individuals with asthma. Anxiety may shape the quality and intensity of dyspnea at a given respiratory load. | yes |
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