pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
24,751,756 | Does indoleamine 2,3-dioxygenase inhibition alter the non-coding RNA transcriptome following renal ischemia-reperfusion injury? | {
"contexts": [
"Indoleamine 2,3 dioxygenase (IDO) degrades the essential amino acid tryptophan and has been shown to minimize rejection in animal models of renal transplantation. Ischemia-reperfusion injury (IRI) is unavoidable in renal transplantation and correlates with shorter graft survival times. Despite it... | These results suggest a biologic role for non-coding, IDO-dependent genes in regulating the early response to IRI. | yes |
24,747,591 | Does combined elevation of microRNA-196a and microRNA-196b in sera predict unfavorable prognosis in patients with osteosarcomas? | {
"contexts": [
"To investigate whether the aberrant expression of microRNA (miR)-196a and miR-196b can be used as potential prognostic markers of human osteosarcoma.",
"Quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR) analysis was performed to detect the expression levels of m... | Our present data indicate the involvement of miR-196a and miR-196b upregulation in the pathogenesis of osteosarcoma. More importantly, the altered levels of circulating miR-196a and miR-196b might have great potential to serve as novel and non-invasive prognostic factors for this malignancy. | yes |
24,747,447 | Does benchmarking trauma centers on mortality alone reflect quality of care : implications for pay-for-performance? | {
"contexts": [
"Trauma centers are currently benchmarked on mortality outcomes alone. However, pay-for-performance measures may financially penalize centers based on complications. Our objective was to determine whether the results would be similar to the current standard method of mortality-based benchmarking i... | Mortality-based external benchmarking does not identify centers with high complication rates. This creates a dichotomy between current trauma center profiling standards and measures used for pay-for-performance. A benchmarking mechanism that reflects all measures of quality is needed. | no |
24,773,337 | Does a prenatal prediction model for total nucleated cell count increase the efficacy of umbilical cord blood banking? | {
"contexts": [
"The most important factor for the selection of an umbilical cord blood unit (CBU) for hematopoietic stem cell transplantation is the total nucleated cell (TNC) count as a surrogate marker for stem cell content in the CBU. At present, about one in five donors can provide a CBU with a sufficient TN... | Our prenatal prediction model increases the efficacy of obtaining informed consent for UCB banking while still allowing relevant numbers of CBUs to be banked. | yes |
24,776,871 | Does assessment of procedural skills using virtual simulation remain a challenge? | {
"contexts": [
"The LAP Mentor is a procedural simulator that provides a stepwise training for laparoscopic cholecystectomy. This study addresses its \"construct\" validity that is present when a simulator is able to discriminate between persons with known differences in performance level on the laparoscopic cho... | Only the full procedure of the LAP Mentor procedural simulator has enough discriminative power to claim construct validity. However, the lack of quality control, which is indispensible in the evaluation of procedural skills, makes it currently unsuited for the assessment of procedural laparoscopic skills. The role of t... | yes |
24,755,250 | Does morus alba L. suppress the development of atopic dermatitis induced by the house dust mite in NC/Nga mice? | {
"contexts": [
"Morus alba, a medicinal plant in Asia, has been used traditionally to treat diabetes mellitus and hypoglycemia. However, the effects of M. alba extract (MAE) on atopic dermatitis have not been verified scientifically. We investigated the effects of MAE on atopic dermatitis through in vitro and in... | Our results suggest that MAE has potent inhibitory effects on atopic dermatitis-like lesion and may be a beneficial natural resource for the treatment of atopic dermatitis. | yes |
24,758,604 | Is nOX2-generated oxidative stress associated with severity of ultrasound liver steatosis in patients with non-alcoholic fatty liver disease? | {
"contexts": [
"Chronic oxidative stress is one of the key mechanisms responsible for disease progression in non-alcoholic fatty liver disease. However, so far, few studies reported increased circulating levels of oxidative stress markers in patients with non-alcoholic fatty liver and no study has been performed... | We demonstrated increased markers of oxidative stress in subjects with non-alcoholic fatty liver. Urinary 8-iso-PGF2α and serum soluble NOX2-derived peptide levels were independent from obesity, diabetes and metabolic syndrome and increased with the severity of liver steatosis at ultrasound. | yes |
24,769,011 | Is preeclampsia in high risk women characterized by risk group-specific abnormalities in serum biomarkers? | {
"contexts": [
"To determine if early pregnancy serum biomarkers in high-risk women who develop preeclampsia vary according to risk factor.",
"We performed a secondary analysis of the Maternal-Fetal Medicine Units Network randomized controlled trial of low-dose aspirin for the prevention of preeclampsia in h... | Patterns of serum biomarkers vary by high-risk group. These data support the hypothesis that multiple pathogenic pathways lead to the disease recognized clinically as preeclampsia. | yes |
24,771,334 | Are mannose-binding lectin gene , MBL2 , polymorphisms associated with susceptibility to invasive pneumococcal disease in children? | {
"contexts": [
"Most children are transiently colonized with Streptococcus pneumoniae, but very few develop invasive pneumococcal disease (IPD). Host genetic variation of innate immunity may predispose to IPD. We investigated the effect of genetic variation in the mannose-binding lectin gene, MBL2, on susceptibi... | Defective MBL2 polymorphisms did not predict increased IPD susceptibility in children born in Northern Europe. | no |
24,778,028 | Does mALDI imaging on tissue microarrays identify molecular features associated with renal cell cancer phenotype? | {
"contexts": [
"To identify molecular features associated with clinico-pathological parameters in renal cell cancer.",
"Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging was employed for a kidney cancer tissue microarray containing tissue samples from 789 patients for which clinic... | Our data pinpoint towards various molecules with potential relevance in renal cell cancer. They also demonstrate that the combination of the MALDI mass spectrometry imaging and large-scale tissue microarray platforms represents a powerful approach to identify clinically-relevant molecular cancer features. | yes |
24,778,024 | Is formyl Peptide receptor 1 expression associated with tumor progression and survival in gastric cancer? | {
"contexts": [
"Formyl peptide receptor 1 (FPR1) as a regulator of innate inflammatory response has been implicated in tumor progression of gliomas. The purpose of the present study was to evaluate the prognostic significance and the ligand-receptor interaction of FPR1 in gastric cancer (GC).",
"FPR1 was imm... | FPR1 expression may be used as a novel indicator to predict outcome in GC patients after gastrectomy. | yes |
24,761,760 | Does smokeless tobacco increase aneuploidy in oral HPV16 E6/E7-transformed keratinocytes in vitro? | {
"contexts": [
"The scope of this work was to study synergism between human papillomavirus (HPV) infection and tobacco in vitro, both known to be independent risk factors for oral cancer.",
"HPV-positive and HPV-negative oral keratinocytes and oral HPV-negative fibroblasts were exposed to smokeless tobacco e... | The effect of STE varied in the cell lines studied. STE2 increased significantly the proportion of aneuploid cells in HPV-positive oral keratinocytes, but not HPV16 E6/E7 expression. This indicates that tobacco products may enhance the effects of HPV 16 and the risk of DNA aneuploidy increasing risk to malignant transf... | yes |
24,749,562 | Does eGR1 support the osteogenic differentiation of dental stem cells? | {
"contexts": [
"To evaluate whether and how the transcription factor early growth response gene 1 (EGR1) affects the osteogenic differentiation of dental stem cells.",
"Dental stem cells from apical papilla (SCAPs) and from the dental follicle (DFCs) were transfected with EGR1-specific siRNA or EGR-1 express... | EGR1 supported the osteogenic differentiation of dental stem cells by potentially regulating the expression of DLX3 and BMP2. | yes |
24,761,217 | Does metronomic oral paclitaxel show anti-tumor effects in an orthotopic mouse model of ovarian cancer? | {
"contexts": [
"The purpose of this study was to compare the in vivo anti-tumor efficacy of a mucoadhesive, lipid-based, oral paclitaxel formulation (DHP107) with traditional, intraperitoneal (IP) paclitaxel using an orthotopic mouse model of chemotherapy-sensitive SKOV3ip1 ovarian cancer.",
"To determine th... | Metronomic oral chemotherapy with DHP107 showed anti-tumor efficacy in vivo similar to IP paclitaxel in an orthotopic mouse model. | yes |
24,757,142 | Does activation of spinal NF-κB/p65 contribute to peripheral inflammation and hyperalgesia in rat adjuvant-induced arthritis? | {
"contexts": [
"It is known that noxious stimuli from inflamed tissue may increase the excitability of spinal dorsal horn neurons (a process known as central sensitization), which can signal back and contribute to peripheral inflammation. However, the underlying mechanisms have yet to be fully defined. A number ... | These findings indicate that spinal NF-κB/p65 plays an important role in the initiation and development of both peripheral inflammation and hyperalgesia. Thus, inhibition of spinal NF-κB/p65 expression may provide a potential treatment to manage painful inflammatory disorders. | yes |
24,757,143 | Is endogenous myeloperoxidase a mediator of joint inflammation and damage in experimental arthritis? | {
"contexts": [
"Myeloperoxidase (MPO) is implicated as a local mediator of tissue damage when released extracellularly in many chronic inflammatory diseases. The purpose of this study was to explore the role of endogenous MPO in experimental rheumatoid arthritis (RA).",
"K/BxN serum-transfer arthritis was in... | MPO contributes to the development of arthritis despite suppressing adaptive immunity in secondary lymphoid organs. This suggests distinct effects of local MPO on arthritogenic effector responses. | yes |
24,757,140 | Does rebamipide suppress collagen-induced arthritis through reciprocal regulation of th17/treg cell differentiation and heme oxygenase 1 induction? | {
"contexts": [
"Rebamipide, a gastroprotective agent, has the ability to scavenge reactive oxygen radicals. Increased oxidative stress is implicated in the pathogenesis of rheumatoid arthritis (RA). We undertook this study to investigate the impact of rebamipide on the development of arthritis and the pathophysi... | The inhibitory effects of rebamipide on joint inflammation are associated with recovery from an imbalance between Th17 cells and Treg cells and with activation of an Nrf2/HO-1 antioxidant pathway. | yes |
24,757,148 | Does long noncoding RNA related to cartilage injury promote chondrocyte extracellular matrix degradation in osteoarthritis? | {
"contexts": [
"Long noncoding RNAs (lncRNAs) play crucial regulatory roles in diverse biologic processes, but knowledge of lncRNAs in osteoarthritis (OA) is limited. The aim of this study was to identify lncRNA expression in articular cartilage and to explore the function of cartilage injury-related lncRNAs (ln... | The results indicate that lncRNA-CIR contributes to ECM degradation and plays a key role in the pathogenesis of OA. We propose that lncRNA-CIR could be used as a potential target in OA therapy. | yes |
24,750,691 | Does hIV Tat protein affect circadian rhythmicity by interfering with the circadian system? | {
"contexts": [
"Sleep disorders are common in patients with HIV/AIDS, and can lead to poor quality of life. Although many studies have investigated the aetiology of these disorders, it is still unclear whether impaired sleep quality is associated with HIV itself, social problems, or side effects of antiretrovira... | The HIV Tat protein affects circadian rhythmicity by interfering with the circadian system in patients with HIV/AIDS and further increases the melatonin excretion value. A Tat protein-related high melatonin value may counteract HIV-related poor sleep quality during the progression of HIV infection. This study provides ... | yes |
24,762,453 | Does provider awareness alone improve transition readiness skills in adolescent patients with inflammatory bowel disease? | {
"contexts": [
"Adolescent patients with chronic health conditions must gradually assume responsibility for their health. Self-management skills are needed for a successful transfer from adolescent to adult health care, but the development of these skills could be resource intensive. Pediatric providers are alre... | Increasing awareness around transition readiness for pediatric providers had an insignificant effect on the self-management skills of patients with IBD. A more formal or structured approach is likely required to improve transition skills in adolescent patients. | no |
24,748,758 | Do the effectiveness of four methods for stain removal from direct resin-based composite restorative materials? | {
"contexts": [
"Few studies investigated the best method for removing stains from different types of resin-based composite restorations and compared them to the more recently introduced nanocomposites. This study compared the effect of four methods for stain removal from composite resins; finishing with Sof-lex ... | Compositions of resin-based composite resins play an important role in their susceptibility to stain and their amenability to stain removal procedures. Home bleaching showed good results for the three materials, while office bleach was the least effective. | yes |
24,761,970 | Is time-domain T-wave alternans strongly associated with a history of ventricular fibrillation in patients with Brugada syndrome? | {
"contexts": [
"T-wave alternans (TWA) is an indicator of vulnerability to ventricular arrhythmias and is useful for predicting sudden cardiac death (SCD) in patients with various structural heart diseases. We evaluated whether high levels of time-domain TWA on ambulatory ECG (AECG) are associated with a history... | Elevated time-domain TWA on AECG confirms arrhythmia risk in symptomatic BrS patients without the need for provocative stimuli. | yes |
24,777,651 | Does analytical function for beta and gamma absorbed fractions of iodine-131 in spherical and ellipsoidal volumes? | {
"contexts": [
"The beta and gamma absorbed fractions in organs and tissues are the important key factors of radionuclide internal dosimetry based on Medical Internal Radiation Dose (MIRD) approach.",
"The aim of this study is to find suitable analytical functions for beta and gamma absorbed fractions in sph... | The analytical functions that we obtained from fitting process in Monte Carlo data can be used for obtaining the absorbed fractions of iodine-131 beta and gamma rays for any volume of the thyroid lobe. Moreover, our results for the spheres are in good agreement with the results of MIRD and other scientific literatures. | yes |
24,770,870 | Do base excision repair defects invoke hypersensitivity to PARP inhibition? | {
"contexts": [
"PARP-1 is important for the recognition of both endogenous and exogenous DNA damage, and binds to DNA strand breaks including intermediates of base excision repair (BER). Once DNA-bound, PARP-1 becomes catalytically activated synthesizing PAR polymers onto itself and other repair factors (PARylat... | BER deficiency represents a new therapeutic opportunity to enhance PARPi efficacy. | yes |
24,766,450 | Are subnormal levels of vitamin D associated with acute wheeze in young children? | {
"contexts": [
"This study evaluated risk factors for acute wheeze in preschool children and investigated whether subnormal levels of vitamin D were associated with increased risk for acute wheeze, atopy or viral/bacterial respiratory infections.",
"We recruited 130 children with acute wheeze, aged 6 months ... | Our findings support the hypothesis that subnormal levels of vitamin D are associated with acute wheeze in young children. | yes |
24,746,942 | Is the systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber independent of age and body size? | {
"contexts": [
"Asthma guidelines recommend prescription of inhaled corticosteroids at a reduced dosage in children compared to older patients in order to minimize the systemic exposure and risk of unwanted side effects. In children, pressurized metered dose inhalers (pMDI) are recommended in combination with a ... | The systemic exposure to the active ingredients of a fixed dose combination of beclometasone/formoterol administered via pMDI with AeroChamber Plus™ correlates with the nominal dose independently of patient age and body size. Thus, dose reduction in relation to age when using a pMDI with VHC may be unnecessary for redu... | yes |
24,763,207 | Is active Transportation to and on Campus Associated With Objectively Measured Fitness Outcomes Among College Students? | {
"contexts": [
"Active transportation (AT) has been associated with positive health outcomes, yet limited research has addressed this with college students, a population at-risk for inactivity. The purpose of this study was to examine the relationship between AT behavior and objectively measured fitness outcomes... | This study documents a relationship between AT behavior and objectively measured fitness among college students and provides a rationale for targeting this behavior as a method for improving health outcomes. | yes |
24,773,920 | Do pseudomonas aeruginosa clinical and environmental isolates constitute a single population with high phenotypic diversity? | {
"contexts": [
"Pseudomonas aeruginosa is an opportunistic pathogen with a high incidence of hospital infections that represents a threat to immune compromised patients. Genomic studies have shown that, in contrast to other pathogenic bacteria, clinical and environmental isolates do not show particular genomic d... | Contrary to what has been described for other bacteria we have found that the P. aeruginosa core genome is constituted by a high proportion of genes and that its pan-genome is thus relatively small. Considering the high degree of genomic conservation between isolates of P. aeruginosa from diverse environments, includin... | yes |
24,764,060 | Are gene-rich large deletions overrepresented in POAG patients of Indian and Caucasian origins? | {
"contexts": [
"Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible bl... | To our knowledge, our study is the first report on large CNV bias for gene-rich regions in glaucomatous neurodegeneration, implicating its impact across populations of contrasting ethnicities. We identified CNTN4 as a novel candidate gene for POAG. | yes |
24,767,520 | Do ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis differ in symptom intensity or response to onabotulinum toxin A? | {
"contexts": [
"To determine whether intratrigonal Onabotulinum toxin A (OnabotA) injection produces a different symptomatic outcome and duration of effect on ulcerative (Ulc) and nonulcerative (NUlc) bladder pain syndrome/interstitial cystitis (BPS/IC) patients and to compare the urinary levels of neurotrophine... | In this cohort, Ulc and NUlc patients had similar symptoms at baseline and comparable clinical response to intratrigonal OnabotA. These findings suggest that pain may not be directly related with ulcers themselves. | no |
24,761,388 | Does factor V Leiden have a role in cryptogenic ischemic stroke among Iranian young adults? | {
"contexts": [
"Different risk factors have been suggested for ischemic stroke in young adults. In a group of these patients despite of extensive diagnostic work-up, the primary cause remains unknown. Coagulation tendency is accounted as a possible cause in these patients. Previous studies on factor V Leiden (FV... | Based on our study, FVL might not be considered as an independent risk factor for ischemic stroke in Iranian individuals who are not suffering from other risk factors of ischemic stroke. | no |
24,772,124 | Does qT dispersion increase with low glomerular filtration rate in patients with coronary artery disease? | {
"contexts": [
"We aimed to evaluate the relationship between estimated glomerular filtration rate (eGFR) and QT dispersion (QTd) in patients with coronary artery disease (CAD).",
"Sixty patients(mean age 62.72 ± 12.48 years) included 46 male, (mean age 60.89 ± 12.70 years)and 14 female (mean age 68.71± 9.86... | QTd tends to be higher in patients with poor renal function independent of severity of angiographical CAD. QTd may be a potentially useful non-invasive test in the management of patients with poor renal function, especially those with CAD. | yes |
24,751,108 | Does rNA sequencing identify novel markers of non-small cell lung cancer? | {
"contexts": [
"The development of reliable gene expression profiling technology increasingly impacts our understanding of lung cancer biology. Here, we used RNA sequencing (RNA-Seq) to compare the transcriptomes of non-small cell lung cancer (NSCLC) and normal lung tissues and to investigate expression in lung ... | CBX3 and CRABP2 expression was markedly increased in lung cancer tissues and especially CRABP2 may be promising candidate genes in lung adenocarcinoma. | yes |
24,747,056 | Is hepatic encephalopathy associated with slowed and delayed stimulus-associated somatosensory alpha activity? | {
"contexts": [
"Hepatic encephalopathy (HE) is associated with motor symptoms and attentional deficits, which are related to pathologically slowed oscillatory brain activity. Here, potential alterations of oscillatory activity in the somatosensory system were investigated.",
"21 patients with liver cirrhosis... | The present results provide the first evidence for a slowing of oscillatory activity in the somatosensory system in HE in combination with a previously unknown deficit of S1 in adjusting activation levels back to baseline. | yes |
24,766,279 | Does sulfhydration of p66Shc at cysteine59 mediate the antioxidant effect of hydrogen sulfide? | {
"contexts": [
"Mitochondrion is considered as the major source of intracellular reactive oxygen species (ROS). H2S has been reported to be an antioxidant, but its mechanism remains largely elusive. P66Shc is an upstream activator of mitochondrial redox signaling. The aim of this study was to explore whether the... | H2S inhibits mitochondrial ROS production via the sulfhydration of Cys-59 residue, which in turn, prevents the phosphorylation of p66Shc. | yes |
24,753,182 | Is hER-2 expression prognostic in osteosarcoma ; a Children 's Oncology Group prospective biology study? | {
"contexts": [
"Since the initial reports of human epidermal growth factor receptor 2 (HER-2) expression as being prognostic in osteosarcoma, numerous small studies varying in the interpretation of the immunohistochemical (IHC) staining patterns have produced conflicting results. The Children's Oncology Group th... | HER-2 expression is not prognostic in osteosarcoma in the context of this large prospective study. HER-2 expression cannot be used as a basis for stratification of therapy. Identification of potential prognostic factors should occur in the context of large multi-institutional biology studies. | no |
24,766,737 | Does shaoYao decoction ameliorate colitis-associated colorectal cancer by downregulating proinflammatory cytokines and promoting epithelial-mesenchymal transition? | {
"contexts": [
"Shaoyao decoction (SYD) is a traditional Chinese medicine prescription formulated by Liu Wan-Su, a master of traditional Chinese medicine in Jin-Yuan Dynasty. SYD is effective in treating ulcerative colitis. Paeonol, a component of SYD, inhibits colorectal cancer (CRC) cell proliferation and indu... | SYD ameliorates caCRC by suppressing inflammation and inhibiting EMT. SYD might be an alternative therapy for caCRC. | yes |
24,768,206 | Does gestational diabetes mellitus alter apoptotic and inflammatory gene expression of trophobasts from human term placenta? | {
"contexts": [
"Increased placental growth secondary to reduced apoptosis may contribute to the development of macrosomia in GDM pregnancies. We hypothesize that reduced apoptosis in GDM placentas is caused by dysregulation of apoptosis related genes from death receptors or mitochondrial pathway or both to enhan... | Maternal GDM results in heavier placentas with aberrant placental apoptotic and inflammatory gene expression that may account, at least partially, for macrosomia in newborns. | yes |
24,766,300 | Are antihelminthic benzimidazoles novel HIF activators that prevent oxidative neuronal death via binding to tubulin? | {
"contexts": [
"Pharmacological activation of the adaptive response to hypoxia is a therapeutic strategy of growing interest for neurological conditions, including stroke, Huntington's disease, and Parkinson's disease. We screened a drug library with known safety in humans using a hippocampal neuroblast line exp... | These studies demonstrate that tubulin-binding drugs can activate a component of the hypoxic adaptive response, specifically the stabilization of HIF-1α and its downstream targets. Tubulin-binding drugs, including antihelminthic benzimidazoles, also abrogate oxidative neuronal death in primary neurons. Given their safe... | yes |
24,755,295 | Does microRNA-181a promote tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1? | {
"contexts": [
"Given the emerging role of microRNA in tumor disease progression, we investigated the association between microRNA expression, liver metastasis and prognosis of colorectal cancer.",
"Colorectal cancer tissues from patients with or without liver metastases were profiled to identify differentia... | Our data demonstrate that miR-181a expression is associated with CRC liver metastasis and survival. miR-181a has strong tumor-promoting effects through inhibiting the expression of WIF-1, and its potential role in promoting epithelial-mesenchymal transition. | yes |
24,749,728 | Does inhibition during early adolescence predict alcohol and marijuana use by late adolescence? | {
"contexts": [
"Adolescent substance use has been associated with poorer neuropsychological functioning, but it is unclear if deficits predate or follow the onset of use. The goal of this prospective study was to understand how neuropsychological functioning during early adolescence could predict substance use b... | Compromised inhibitory functioning during early adolescence prior to the onset of substance use was related to more frequent and intense alcohol and marijuana use by late adolescence. Inhibition performance could help identify teens at risk for initiating heavy substance use during adolescence, and potentially could be... | yes |
24,753,748 | Does miRNA-26b inhibit cellular proliferation by targeting CDK8 in breast cancer? | {
"contexts": [
"MicroRNA-26b (miR-26b) has been reported to be down-regulated in a wide range of malignant tumors, However, the mechanism by which miR-26b is implicated in breast cancer tumorigenesis is incompletely understood. This study was undertaken to evaluate the expression pattern of miR-26b and character... | These findings suggest that miR-26b exerts a tumor suppressive role in breast cancer and the miR-26b-mediated growth inhibition is achieved through suppression of a new target gene CDK8. | yes |
24,753,749 | Are activation of circulated immune cells and inflammatory immune adherence involved in the whole process of acute venous thrombosis? | {
"contexts": [
"To investigate localization and distribution of integrin subunit β1, β2 and β3 and morphological changes of ligand-recepter binding in thrombi of acute pulmonary embolism (PE) patients and explore activation of circulated immune cells, inflammatory immune adherence and coagulation response in acu... | Acute venous thrombosis is an activation process of circulated lymphocytes, neutrophils and platelets mainly, and a whole process including integrin subunit β2 and β3 binding with their ligands. Activation of immune cells, inflammatory immune adherence and coagulation response are involved in the acute venous thrombosi... | yes |
24,755,130 | Does flurbiprofen improve dysfunction of T-lymphocyte subsets and natural killer cells in cancer patients receiving post-operative morphine analgesia? | {
"contexts": [
"Acute pain can lead to immune dysfunction, which can be partly ameliorated by successful pain management. Opioids, which are widely used for analgesia, can result in the deterioration of immune function. This study aimed to investigate the influence of morphine with or without flurbiprofen as pos... | The combination of morphine and flurbiprofen ameliorates the immune depression in Tlymphocyte subsets and natural killer cells and provides a similar analgesic efficacy to morphine alone in patients undergoing gastric cancer surgery. | yes |
24,755,071 | Are human adipocytes highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression? | {
"contexts": [
"Intermittent hypoxia (IH)-induced activation of pro-inflammatory pathways is a major contributing factor to the cardiovascular pathophysiology associated with obstructive sleep apnea (OSA). Obesity is commonly associated with OSA although it remains unknown whether adipose tissue is a major sourc... | Human adipocytes demonstrate strong sensitivity to inflammatory gene expression in response to acute IH and hence, adipose tissue may be a key source of inflammatory mediators in OSA. | yes |
24,749,241 | Does increasing functional variability in the preparatory phase of the takeoff improve elite springboard diving performance? | {
"contexts": [
"Previous research demonstrating that specific performance outcome goals can be achieved in different ways is functionally significant for springboard divers whose performance environment can vary extensively. This body of work raises questions about the traditional approach of balking (terminatin... | Results suggested that on completion of training, athletes were capable of successfully adapting their movement patterns under more varied takeoff conditions to achieve greater consistency and stability of performance outcomes. | yes |
24,754,509 | Are anticytomegalovirus antibody titres associated with caregiving burden in younger caregivers? | {
"contexts": [
"This analysis examines whether or not younger caregivers, parents of children with developmental disabilities, differed from controls in terms of cytomegalovirus (CMV) seropositivity and CMV-specific antibody titre. Secondly, it examined whether any particular socio-demographics, health behaviour... | These data suggest that in the absence of immunosenescence, the chronic stress of caregiving is not sufficient to compromise the immune response to persistent CMV infection. However, an indirect mechanism to poorer health in caregivers might be via adoption of disadvantageous health behaviours in response to stress. St... | no |
24,749,793 | Is maternal sleep duration and complaints of vital exhaustion during pregnancy associated with placental abruption? | {
"contexts": [
"Sleep disorders are associated with cardiovascular complications and preterm delivery (PTD). Insufficient sleep results in metabolic alterations and increased inflammation, both known to contribute to placental abruption (abruption), a determinant of PTD. We examined associations of abruption wit... | We extend the existing literature and support the thesis that maternal sleep habits and disorders should be assessed among pregnant women. | yes |
24,749,794 | Is the passage of meconium alone a sign of correctly positioned anus? | {
"contexts": [
"The aim of this study is to determine the consequences of delayed presentation of anorectal malformations and emphasize the causes of delayed diagnosis of these malformations.",
"We retrospectively reviewed 54 neonatal patients with a diagnosis of anorectal malformations. Group 1 consisted of... | The passage of meconium is not the only sign of correctly positioned anus. A careful physical examination and awareness of this anomaly are of great importance in making a timely diagnosis of anorectal malformations. | no |
24,769,132 | Is endocan useful biomarker of survival and severity in sepsis? | {
"contexts": [
"Coagulation abnormalities which occur as a consequence of endothelial changes are recognized as diagnostic criteria for sepsis, but significance of these changes in the outcome prognosis and prediction of the course of sepsis is still not accurately defined.",
"60 patients who fulfilled the c... | Results of our study show that endocan can be used as strong and significant predictor of sepsis severity and outcome, perhaps even better than SOFA and APACHE II scores. | yes |
24,752,868 | Does hepatocyte nuclear factor 4α-nuclear factor-κB feedback circuit modulate liver cancer progression? | {
"contexts": [
"Hepatocyte nuclear factor 4α (HNF4α) is a liver enriched transcription factor and is indispensable for liver development. However, the role of HNF4α in hepatocellular carcinoma (HCC) progression remains to be elucidated. We report that reduced HNF4α expression correlated well with the aggressive ... | Collectively, an HNF4α-NF-κB feedback circuit including miR-124, miR-7, and miR-21 was identified in HCC, and the combination of HNF4α and NF-κB exhibited more powerful predictive efficiency of patient prognosis. These findings broaden the knowledge of hepatic inflammation and cancer initiation/progression, and also pr... | yes |
24,751,748 | Do intraoperative measurement for a new transcutaneous bone conduction hearing implant? | {
"contexts": [
"To investigate the possibility of using a modified reverse transfer function (RTF) measurement intraoperatively during surgery of a new transcutaneous bone conduction hearing implant to evaluate the status of the device.",
"Tests were performed on a cadaver skull (preclinically) and two condu... | The usage of an intraoperative RTF measurement may be a good method to verify the mechanical coupling of the bone conduction floating mass transducer and to test the functional integrity of the implant in an objective way. | yes |
24,752,092 | Does [ Sanhuangyinchi decoction pretreatment ameliorate acute hepatic failure in rats by suppressing antioxidant stress and caspase-3 expression ]? | {
"contexts": [
"To observe the effects of Sanhuangyinchi decoction (SHYCD) pretreatment on acute hepatic failure (AHF) induced by D-galactosamine and lipopolysaccharide (LPS) in rats and explore the possible mechanisms involving antioxidant stress and cell apoptosis-related protein expression.",
"Forty-eight... | SHYCD pretreatment can dose-dependently ameliorate AHF in rats possibly by suppressing antioxidant stress and caspase-3 expression to decrease hepatic cell apoptosis. | yes |
24,752,094 | Does [ 1,25-dihydroxyvitamin D3 pretreatment inhibit house dust mite-induced thymic stromal lymphopoietin release by human airway epithelial cells ]? | {
"contexts": [
"To investigate the effect of 1,25-dihydroxyvitamin D3 (1,25VD3) on house dust mites (HDM)-induced expression of thymic stromal lymphopoietin (TSLP) in human airway epithelial cells in vitro.",
"Human airway epithelial 16HBE cells were incubated with 200, 400, and 800 U/L in the absence or pre... | Both 1,25VD3 and HDM can induce TSLP expression and release in 16HBE cells, but pretreatment with 1,25VD3 can decrease HDM-augmented TSLP expression in the cells. | yes |
24,752,098 | Does [ SCF/c-Kit signaling promote invasion of T24 cells via PI3K pathway ]? | {
"contexts": [
"To explore the role of SCF/c-Kit signaling in the invasion of bladder cancer T24 cells.",
"Western blotting was used to detect the expression of c-Kit and PI3K pathway activation stimulated by stem cell factor (SCF) in T24 cells. The invasiveness of T24 cells before and after SCF stimulation ... | SCF/c-Kit signaling promotes the invasiveness of T24 cells, and this effect is mediated by the PI3K pathway. | yes |
24,752,115 | Does [ Serum follicle-stimulating hormone in combination with serum inhibin B evaluate spermatogenesis of azoospermic men ]? | {
"contexts": [
"This study is in an attempt to evaluate the diagnostic significance to predict the spermatogenesis of azoospermic men in examination of serum follicle-stimulating hormone (FSH) combination with serum inhibin B (INHB).",
"Quantitative examination of serum FSH and INHB was performed in 95 case ... | Serum FSH and INHB levels is ineffective to distinguish the spermatogenic classifications from azoospermic men, but they are available to confirm the disease of Sertoli cell only. The other abnormalities of azoospermic men is also dependent on bioptic histopathology to confirm the subtypes. | yes |
24,773,080 | Does highly prevalent SERPINB7 founder mutation cause pseudodominant inheritance pattern in Nagashima-type palmoplantar keratosis? | {
"contexts": [
"Nagashima-type palmoplantar keratosis (NPPK) is a distinct autosomal recessive genodermatosis characterized by diffuse transgressive palmoplantar keratoderma (PPK). Very recently, putative loss-of-function mutations in SERPINB7, which encodes a member of the serine protease inhibitor superfamily ... | These data clearly provide further evidence that NPPK is caused by loss-of-function mutations in SERPINB7. | yes |
24,751,313 | Do augmentative therapies potentiate the antidepressant-like effects of deep brain stimulation in rats? | {
"contexts": [
"Clinical trials have shown promising results with the use of subcallosal cingulate gyrus deep brain stimulation (DBS) for treatment-resistant depression. However, strategies to manage patients who do not respond to this therapy have not been explored in detail. In rats, DBS in the ventromedial pr... | Despite having good predictive validity, animal models are limited from a translational perspective. | no |
24,751,319 | Does both body weight and BMI predict improvement in symptom and functioning for patients with major depressive disorder? | {
"contexts": [
"Obesity has shown a positive association with depression. We aimed to investigate the relationships among body weight, body mass index (BMI=kg/m(2)), change in a depression rating scale, and change in a functional scale with fluoxetine treatment for hospitalized patients with major depressive dis... | This is a short-term trial with relatively small sample size. | yes |
24,749,506 | Is density and duration of pneumococcal carriage maintained by transforming growth factor β1 and T regulatory cells? | {
"contexts": [
"Nasopharyngeal carriage of Streptococcus pneumoniae is a prerequisite for invasive disease, but the majority of carriage episodes are asymptomatic and self-resolving. Interactions determining the development of carriage versus invasive disease are poorly understood but will influence the effectiv... | These data explain the mechanisms by which S. pneumoniae colonize the human nasopharynx without inducing damaging host inflammation and provide insight into the role of bacterial and host constituents that allow and maintain carriage. | yes |
24,758,222 | Does chronic stress impair GABAergic control of amygdala through suppressing the tonic GABAA receptor currents? | {
"contexts": [
"Chronic stress is generally known to exacerbate the development of numerous neuropsychiatric diseases such as fear and anxiety disorders, which is at least partially due to the disinhibition of amygdala subsequent to the prolonged stress exposure. GABA receptor A (GABAAR) mediates the primary com... | Our study suggests that enduring loss of tonic but not phasic GABAAR currents critically contributes to the prolonged amygdala disinhibition subsequent to chronic stress. We propose that the preferential loss of tonic inhibition may account for the development of stress-related neuropsychiatric diseases. | yes |
24,758,223 | Do brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke? | {
"contexts": [
"Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disturbance in which patients enact their dreams while in REM sleep. The behavior is typically violent in association with violent dream content, so serious harm can be done to the patient or the bed partner. The prevalence of RBD ... | The results support the notion of a predominant role of brainstem injury in the development of RBD and suggest that patients with brainstem infarcts RBD should be evaluated by a clinical neurologist. | yes |
24,758,227 | Does severe hypoxia exert parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells? | {
"contexts": [
"The endosteum of the bone marrow provides a specialized hypoxic niche that may serve to preserve the integrity, pluripotency, longevity and stemness of resident mesenchymal stem cells (MSCs). To explore the molecular genetic consequences of such a niche we subjected human (h) MSCs to a pO2 of 4 m... | We conclude that severe hypoxia confers a quiescent phenotype in hMSCs that is reflected by both the transcriptome profile and gene-specific changes of splicosome actions. The results reveal that severe hypoxia imposes markedly different patterns of gene regulation of MSCs compared with more moderate hypoxia. This is t... | yes |
24,750,438 | Does impact of postoperative renal replacement therapy on long-term outcome after cardiac surgery increase with age? | {
"contexts": [
"In the present study, we investigated the survival of patients who received postoperative renal replacement therapy (RRT) after cardiac surgery. We specifically focused on factors predicting long-term outcome in elderly patients.",
"Data of all patients that received unintentional renal repla... | Patients requiring RRT after cardiac surgery have a poor prognosis with a high mortality. Older age predicted both 30-day and late mortality in these patients. | yes |
24,773,329 | Does collaborative DTM reduce hospitalization and healthcare costs in patients with diabetes treated with polypharmacy? | {
"contexts": [
"To evaluate the effects of a collaborative pharmacy benefits manager (PBM)/ health plan-administered drug therapy management (DTM) program on healthcare utilization and costs in patients with diabetes treated with polypharmacy.",
"Retrospective quasi-experimental design with comparison group.... | A collaborative pharmacist-driven DTM program with a care manager-executed patient outreach component results in reduced hospital utilization and significant healthcare cost savings. | yes |
24,772,492 | Does tetanus toxin reduce local and descending regulation of the H-reflex? | {
"contexts": [
"Skeletal muscles that are under the influence of tetanus toxin show an exaggerated reflex response to stretch. We examined which changes in the stretch reflex may underlie the exaggerated response.",
"H-reflexes were obtained from the tibialis anterior (TA) and flexor digitorum brevis (FDB) m... | Tetanus toxin increased the amplitude of the Hwave and reduced the normal depression of H-wave amplitude that is associated with closely timed stimuli, two phenomena that could contribute to hyperactivity of the stretch reflex. | yes |
24,755,710 | Is arterial blood pressure closely related to ascites development in compensated HCV-related cirrhosis? | {
"contexts": [
"Arterial blood pressure (BP) is a reliable marker of circulatory dysfunction in cirrhotic patients. There are no prospective studies evaluating the association between different levels of arterial BP and ascites development in compensated cirrhotic patients. Therefore, we evaluated the relationsh... | The MAP is closely related to the development of ascites in compensated HCV-related cirrhosis. The risk of ascites development increases in 4.4 fold for subjects with MAP values <83.32 mm/Hg. | yes |
24,755,712 | Is evidence that the lung Adenocarcinoma EML4-ALK fusion gene caused by exposure to secondhand tobacco smoke during childhood? | {
"contexts": [
"The EML4-ALK fusion gene is more frequently found in younger, never smoking patients with lung cancer. Meanwhile, never smokers exposed to secondhand tobacco smoke (SHS) during childhood are diagnosed at a younger age compared with never smoking patients with lung cancer who are not exposed. We, ... | The EML4-ALK fusion gene is not enriched in tumors from individuals exposed to SHS during childhood. | no |
24,769,857 | Are genetic variants in microRNA machinery genes associated [ corrected ] with idiopathic recurrent pregnancy loss risk? | {
"contexts": [
"Key molecules involved in microRNA (miRNA) biogenesis, such as DROSHA, XPO5, and DICER, have been identified in trophoblast cells, confirming that the miRNA biogenesis pathway is active in human placenta. In addition, miRNAs regulate uterine gene expression associated with inflammatory responses ... | Our study demonstrates the relationship between RPL development and the polymorphism of the miRNA machinery gene RAN and combined genotype of DROSHA/DICER. | yes |
24,760,181 | Is collagen type III alpha 1 polymorphism ( rs1800255 , COL3A1 2209 G > A ) assessed with high-resolution melting analysis associated with pelvic organ prolapse in the Dutch population? | {
"contexts": [
"The rs1800255, COL3A1 2209 G>A polymorphism in the alpha 1 chain of collagen type III has been associated with an increased risk of pelvic organ prolapse (POP). In one of our previous studies however, polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) misdiagnosed... | The previously found statistically significant association between the rs1800255, COL3A1 2209 G>A polymorphism as measured with PCR-RFLP and POP could no longer be demonstrated. This raises concerns regarding the results of other association studies using PCR-RFLP. | no |
24,771,329 | Is severe malarial anemia associated with long-term neurocognitive impairment? | {
"contexts": [
"Cerebral malaria (CM) is associated with long-term neurocognitive impairment in children ≥5 years of age. No prospective studies to date have assessed neurocognitive impairment in children with CM <5 years of age, or in children with severe malarial anemia (SMA), a form of severe malaria estimate... | In children <5 years of age, SMA is associated with long-term impairment in cognitive ability, whereas CM is associated with additional impairment in the areas of attention and associative memory. SMA may be a major contributor to long-term neurocognitive impairment in children in sub-Saharan Africa. | yes |
24,759,437 | Do neural responses to exclusion predict susceptibility to social influence? | {
"contexts": [
"Social influence is prominent across the lifespan, but sensitivity to influence is especially high during adolescence and is often associated with increased risk taking. Such risk taking can have dire consequences. For example, in American adolescents, traffic-related crashes are leading causes o... | These results address the neural bases of social influence and risk taking; contribute to our understanding of social and emotional function in the adolescent brain; and link neural activity in specific, hypothesized, regions to risk-relevant outcomes beyond the neuroimaging laboratory. Results of this investigation ar... | yes |
24,752,070 | Is viral infection uncommon in adult patients with severe hospital-acquired pneumonia? | {
"contexts": [
"Viral pathogens have not generally been regarded as important causes of severe hospital-acquired pneumonia (HAP), except in patients with hematologic malignancy or transplant recipients. We investigated the role and distribution of viruses in adult with severe HAP who required intensive care.",
... | Viral pathogens are not uncommon in adult patients with severe HAP who required ICU admission. Since viral pathogens may cause severe HAP and could be a potential source of viral transmission, further investigation is required to delineate the role of viral pathogens in severe HAP. | no |
24,764,283 | Is proteinuria testing among patients with diabetes mellitus associated with bladder cancer diagnosis : potential for unmeasured confounding in studies of pioglitazone and bladder cancer? | {
"contexts": [
"The observed association between pioglitazone and bladder cancer could be causal or because of bias in the design of prior studies. We hypothesize that proteinuria testing may lead to detection bias if routine test results for proteinuria lead to a full urinalysis.",
"We reanalyzed patients w... | Proteinuria testing may be a confounder in studies of pioglitazone and bladder cancer but does not fully explain the association between pioglitazone and bladder cancer in this cohort. Optimal adjustment for proteinuria testing likely requires knowledge of the test result. | yes |
24,748,941 | Does survey of sonoanatomic distances for lumbar medial branch nerve block in healthy volunteers? | {
"contexts": [
"The precise knowledge of anatomy and the region of transverse process (TP) and superior articular processes (AP) and their distance from the skin are important in blocking and treating lumbar facet syndrome. Evaluation of these anatomic distances from 3rd and 5th lumbar vertebrae in both sides an... | We found many anatomic distances which may increase awareness of US guided LMBB. | yes |
24,761,122 | Does margaritaria discoidea ( Euphorbiaceae ) stem bark extract attenuate allergy and Freund 's adjuvant-induced arthritis in rodents? | {
"contexts": [
"Various parts of Margaritaria discoidea find use in traditional medicine in the treatment of pain and oedema. This study evaluated the anti-allergic, anti-inflammatory and anti-arthritic effects of a 70% (v/v) aqueous ethanol extract of the stem bark of Margaritaria discoidea, MDE in rodents.",
... | Margaritaria discoidea suppresses allergy and exhibits anti-inflammatory activity in mice. In addition it attenuates Freund's adjuvant-induced arthritis through a reduction in serum levels of TNFα and IL-6 in rats. | yes |
24,769,314 | Is stromal transforming growth factor-beta 1 crucial for reinforcing the invasive potential of low invasive cancer? | {
"contexts": [
"Tumour cells alter the characteristics of the adjacent stroma to create a supportive microenvironment during cancer progression. In vitro and in vivo experiments were carried out to verify the role of stromal TGF-β1 in reinforcing of the invasive potential in low invasive cancer.",
"Isolated ... | Stromal TGF-β1 signalling promoted PDPN expression in cancer cells, thereby enhancing tumour growth and leading to a more invasive phenotype. | yes |
24,761,873 | Does eGF reverse multi-drug resistance via the p-ERK pathway in HepG2/ADM and SMMC7721/ADM hepatocellular carcinoma models? | {
"contexts": [
"To investigate signaling pathways for reversal of EGF-mediated multi-drug resistance (MDR) in hepatocellular carcinoma (HCC) models.",
"HCC MDR cell strain HepG2/adriamycin (ADM) and SMMC7721/ADM models were established using a method of exposure to medium with ADM between low and high concen... | EGF might enhance the chemosensitivity of HepG2/ADM and SMMC7721/ADM cells via up-regulating p-ERKs and BimEL protein. | yes |
24,778,708 | Does psychiatric staff on the wards share attitudes on aggression? | {
"contexts": [
"The concept of ward culture has been proposed as a reason for the often reported differences in treatment decisions when managing inpatient aggression. We therefore studied whether staff on wards actually shares similar perceptions and attitudes about aggression and whether the specialty of the w... | Psychiatric staff on the wards does not share attitudes on aggression. As each staff member has his/her own opinion about aggression, training for dealing with aggression or violent incidents should be done, at least partly, on an individual level. We also suggest caution in using the concept of ward culture as an expl... | no |
24,757,138 | Do fcγ receptor III and Fcγ receptor IV on macrophages drive autoimmune valvular carditis in mice? | {
"contexts": [
"Arthritis and valvular carditis coexist in several human rheumatic diseases, including systemic lupus erythematosus, rheumatic fever, and rheumatoid arthritis. T cell receptor-transgenic K/BxN mice develop spontaneous autoantibody-associated arthritis and valvular carditis. The common Fc receptor... | FcγRIII and FcγRIV act redundantly to promote valvular carditis in K/BxN mice with systemic autoantibody-associated arthritis. Macrophage depletion reduced the severity of valve inflammation. These findings suggest that pathogenic autoantibodies engage Fcγ receptors on macrophages to drive valvular carditis. Our study ... | yes |
24,764,073 | Do aM-PAC `` 6-Clicks '' functional assessment scores predict acute care hospital discharge destination? | {
"contexts": [
"Physical therapists and occupational therapists practicing in acute care hospitals play a crucial role in discharge planning. A standardized assessment of patients' function could be useful for discharge recommendations.",
"The study objective was to determine the accuracy of \"6-Clicks\" bas... | Limitations included lack of information on the rater reliability of "6-Clicks" instruments, use of surrogate data for some discharge designations, and use of a clinical database for research purposes. | yes |
24,762,493 | Does proteomic analysis reveal novel proteins associated with progression and differentiation of colorectal carcinoma? | {
"contexts": [
"The objective of this study is to characterize differential proteomic expression among well-differentiation and poor-differentiation colorectal carcinoma tissues and normal mucous epithelium.",
"The study is based on quantitative 2-dimensional gel electrophoresis and analyzed by PDquest.",
... | Their functional networks were analyzed by Ingenuity systems Ingenuity Pathways Analysis and revealed the potential roles as novel biomarkers for progression in various differentiation stages of CRC. | yes |
24,768,874 | Does omentin prevent myocardial ischemic injury through AMP-activated protein kinase- and Akt-dependent mechanisms? | {
"contexts": [
"This study examined the impact of omentin on myocardial injury in a mouse model of ischemia/reperfusion (I/R) and explored its underlying mechanisms.",
"Obesity is a major risk factor for ischemic heart disease. Omentin is a circulating adipokine that is down-regulated by obesity.",
"In p... | Our data indicate that omentin functions as an adipokine that ameliorates acute ischemic injury in the heart by suppressing myocyte apoptosis through both AMPK- and Akt-dependent mechanisms. | yes |
24,768,531 | Are hyperglycemia , hypoglycemia , and glycemic complexity associated with worse outcomes after surgery? | {
"contexts": [
"The purpose of this study was to determine if glycemic complexity, along with hypoglycemia and hyperglycemia, was associated with worse outcomes after cardiac surgery.",
"We conducted a retrospective analysis of 970 patients who had insulin infusions designed to keep blood glucose levels betw... | We found that hypoglycemia (glucose<71 mg/dL) and hyperglycemia (glucose>140 mg/dL) were associated with increased risk of complications, whereas greater complexity of the glucose time series was associated with mortality. | yes |
24,768,533 | Does the Intermountain Risk Score predict mortality in trauma patients? | {
"contexts": [
"Intermountain Risk Score (IMRS) uses the admission complete blood count and basic metabolic profile to predict mortality. Intermountain Risk Score has been validated in medical patients but has not been evaluated in trauma. This study tested whether IMRS is predictive of mortality in a trauma pop... | Intermountain Risk Score strongly predicts mortality in trauma patients at this single level I trauma center. The ability to accurately determine a patient's mortality risk at admission makes IMRS a potentially clinically important tool. | yes |
24,770,679 | Is cytoplasmic YAP expression associated with prolonged survival in patients with lung adenocarcinomas and epidermal growth factor receptor tyrosine kinase inhibitor treatment? | {
"contexts": [
"Yes-associated protein (YAP) has been reported to be associated with the prognosis of various cancers and also to affect epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) activity in ovarian cancer cell lines. However, few studies have evaluated YAP protein expression in lung ... | High cytoplasmic YAP expression predicted a good clinical outcome for patients with lung adenocarcinoma and in EGFR-TKI-treated patients. Therefore, YAP may play a role in EGFR-TKI-treated lung cancer, and YAP targeting may enhance therapeutic effects in combination with other cancer drugs. | yes |
24,773,597 | Does frequency of mealtime insulin bolus predict glycated hemoglobin in youths with type 1 diabetes? | {
"contexts": [
"Within pediatric diabetes management, two electronic measures of adherence exist: frequency of daily blood glucose monitoring (BGM) and the BOLUS score, a measure of frequency of mealtime insulin bolusing. Past research has demonstrated that the BOLUS score is superior to daily BGM in predicting ... | In a prospective, longitudinal design, youths' BOLUS scores were superior to youths' daily BGM in predicting future values of HbA1c. Calculating a BOLUS score versus BGM can help researchers and clinicians achieve a better prediction of youths' HbA1c. | yes |
24,752,914 | Is isatis canescens a rich source of glucobrassicin and other health-promoting compounds? | {
"contexts": [
"Glucobrassicin (GBS), a glucosinolate contained in many brassica vegetables, is the precursor of chemopreventive compounds such as indole-3-carbinol. Large amounts of GBS would be needed to perform studies aimed at elucidating its role in the diet. This study was mainly undertaken to evaluate the... | I. canescens flower buds represent a naturally rich source of GBS, at a level suitable for its purification. Furthermore, flower bud consumption could provide an intake of health-promoting compounds, with possible antioxidant and chemopreventive properties. | yes |
24,757,635 | Does comorbidity influence multiple aspects of well-being of patients with ischemic heart disease? | {
"contexts": [
"Comorbidity is prevalent among patients with Ischemic Heart Disease (IHD) and may influence patients' subjective and objective domains of well-being.",
"We aimed to investigate the associations between comorbidity and different measures of well-being (i.e. health related quality of life, psyc... | This study showed a consistent pattern of associations between somatic comorbidities and multiple aspects of well-being among patients with IHD. Findings may increase cardiologists' interest to identify and treat somatic conditions among IHD patients. | yes |
24,774,536 | Is the effect of Rho kinase inhibition on long-term keratinocyte proliferation rapid and conditional? | {
"contexts": [
"We previously demonstrated that the lifespan of primary human keratinocytes could be extended indefinitely by culture in the presence of the Rho kinase (ROCK) inhibitor Y-27632. This technique has proven to be very useful in diverse areas of basic and clinical research.",
"In this follow-up s... | ROCK inhibition rapidly and conditionally induces indefinite proliferation of keratinocytes. This method has far-reaching applications for basic research, as well as for regenerative and personalized medicine. | yes |
24,758,567 | Does hypoxia augment the calcium-activated chloride current carried by anoctamin-1 in cardiac vascular endothelial cells of neonatal mice? | {
"contexts": [
"The molecular identity of calcium-activated chloride channels (CaCCs) in vascular endothelial cells remains unknown. This study sought to identify whether anoctamin-1 (Ano1, also known as TMEM16A) functions as a CaCC and whether hypoxia alters the biophysical properties of Ano1 in mouse cardiac v... | Ano1 formed CaCC in CVECs of neonatal mice. Hypoxia enhances Ano1-mediated ICl ( C a) density via increasing its expression, altering the ratio of its splicing variants, sensitivity to membrane voltage and to Ca(2+) . Ano1 may play a role in the pathophysiological processes during ischaemia in heart, and therefore, Ano... | yes |
24,762,601 | Do matrix metalloproteinase-8 inhibitors mitigate sepsis-induced myocardial injury in rats? | {
"contexts": [
"Sepsis-induced myocardial injury (SIMI) is caused by a variety of mechanisms. The aim of the study is to investigate the effects of metalloproteinase-8 (MMP-8) on SIMI and its mechanisms in rats.",
"Forty male Sprague Dawley rats were randomly divided into four groups: MMP-8 inhibitor (M8I), ... | MMP-8 inhibitor attenuated myocardial injury in septic rats, which might be related to reduced expression of TNF-α and IL-1β. | yes |
24,762,600 | Does metformin ameliorate insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3? | {
"contexts": [
"SIRT3 is an important regulator in cell metabolism, and recent studies have shown that it may be involved in the pharmacological effects of metformin. However, the molecular mechanisms underlying this process are unclear.",
"The effects of SIRT3 on the regulation of oxidative stress and insul... | Upregulated SIRT3 is involved in the pharmacological mechanism by which metformin promotes glucose uptake. Additionally, SIRT3 may function as an important regulator of oxidative stress and a new alternative approach for targeting insulin resistance-related diseases. | yes |
24,762,604 | Does theanine improve the function of dendritic cells via the downregulation of cyclooxygenase-2 expression? | {
"contexts": [
"Tumor cells can reduce the number of dendritic cells (DCs) in the tumor environment and cause DC dysfunction through autocrine or paracrine pathways. We sought to measure cyclooxygenase-2 (COX-2) expression in bombesin-inhibited DCs treated with theanine in vitro and to explore the protection and... | Theanine inhibits the transcription and translation of COX-2 and regulates the balance of IL-10/IL-12 secretion in bombesin-inhibited DCs, leading to the recovery of a state of activation in DCs. | yes |
24,767,545 | Does optic nerve crush induce spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice? | {
"contexts": [
"Central nervous system (CNS) trauma and neurodegenerative disorders trigger a cascade of cellular and molecular events resulting in neuronal apoptosis and regenerative failure. The pathogenic mechanisms and gene expression changes associated with these detrimental events can be effectively studie... | A number of detrimental gene expression changes occur that contribute to trauma-induced neurodegeneration after injury to ON axons. Nrn1 (synaptic plasticity gene), Synpr and Syt1 (synaptic vesicle fusion genes), and Vsnl1 (neuron differentiation associated gene) were a few of the potentially unique genes identified th... | yes |
24,768,399 | Is cardiopulmonary exercise testing more accurate than ECG-stress testing in diagnosing myocardial ischemia in subjects with chest pain? | {
"contexts": [
"Cardiopulmonary exercise stress testing (CPET) is used to grade the severity of heart failure and to assess its prognosis. However it is unknown whether CPET may improve diagnostic accuracy of standard ECG stress testing to identify or exclude obstructive coronary artery disease (O-CAD) in patien... | In patients with chest pain, CPET showed a better diagnostic and predictive accuracy than traditional ET to detect/exclude myocardial ischemia. Its use should be encouraged among physicians as a first line diagnostic tool in clinical practice. | yes |
24,766,723 | Does long-term reduction of T-cell intracellular antigens lead to increased beta-actin expression? | {
"contexts": [
"The permanent down-regulated expression of T-cell intracellular antigen (TIA) proteins in HeLa cells improves cytoskeleton-mediated functions such as cell proliferation and tumor growth.",
"Making use of human and mouse cells with knocked down/out expression of T-cell intracellular antigen 1 ... | Collectively, these results suggest that TIA proteins can function as long-term regulators of the ACTB mRNA metabolism in mouse and human cells. | yes |
24,749,853 | Does epigenome-wide DNA methylation assay reveal placental epigenetic markers for noninvasive fetal single-nucleotide polymorphism genotyping in maternal plasma? | {
"contexts": [
"The use of DNA methylation difference between maternal blood cell and fetal (placental) DNA is one of the main areas of interest for the development of fetal epigenetics markers in maternal plasma.",
"We employed a methylation array (HumanMethylation450 array, Illumina, Inc.) to identify nove... | The present studies systematically identified hypermethylated sites in fetal tissues and preliminarily demonstrated that some of the fetal epigenetic markers that contain informative SNPs have great potential for noninvasive fetal genetic diagnosis. | yes |
24,755,984 | Does notch pathway target proangiogenic regulator Sox17 to restrict angiogenesis? | {
"contexts": [
"The Notch pathway stabilizes sprouting angiogenesis by favoring stalk cells over tip cells at the vascular front. Because tip and stalk cells have different properties in morphology and function, their transcriptional regulation remains to be distinguished. Transcription factor Sox17 is specifica... | Our findings demonstrate that the Notch pathway restricts sprouting angiogenesis by reducing the expression of proangiogenic regulator Sox17. | yes |
24,755,985 | Does hemodynamic disturbed flow induce differential DNA methylation of endothelial Kruppel-Like Factor 4 promoter in vitro and in vivo? | {
"contexts": [
"Hemodynamic disturbed flow (DF) is associated with susceptibility to atherosclerosis. Endothelial Kruppel-Like Factor 4 (KLF4) is an important anti-inflammatory atheroprotective transcription factor that is suppressed in regions of DF.",
"The plasticity of epigenomic KLF4 transcriptional regu... | Hemodynamics influence endothelial KLF4 expression through DNMT enrichment/myocyte enhancer factor-2 inhibition mechanisms of KLF4 promoter CpG methylation with regional consequences for atherosusceptibility. | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.