pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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24,747,452 | Do mitochondrial damage-associated molecular patterns released by abdominal trauma suppress pulmonary immune responses? | {
"contexts": [
"Historically, fever, pneumonia, and sepsis after trauma are ascribed to pain and poor pulmonary toilet. No evidence supports that assertion however, and no known biologic mechanisms link injury to infection. Our studies show that injured tissues release mitochondria (MT). Mitochondrial damage-ass... | Rather than acting as a "second hit" to enhance PMN-mediated lung injury, mtDAMPs from trauma and pathogen-associated danger molecules from peritoneal infection diminish PMN accumulation in a contused lung. This may make the lung susceptible to pneumonia. This paradigm provides a novel mechanistic model of the relation... | yes |
24,764,203 | Does nicotinamide treatment ameliorate the course of experimental colitis mediated by enhanced neutrophil-specific antibacterial clearance? | {
"contexts": [
"In previous studies, we could show that the B vitamin nicotinamide (NAM) enhanced antimicrobial activity of neutrophils. Here, we assessed the effects of NAM in two models of experimental colitis.",
"Colitis was induced in C57BL/6 mice either by oral infection with Citrobacter rodentium or by... | Pharmacological application of NAM mediates beneficial effects in bacterial and chemically induced colitis. Future studies are needed to explore the clinical potential of NAM in the context of intestinal bacterial infections and human inflammatory bowel disease (IBD). | yes |
24,757,031 | Is variation in mortality among populations higher for pymetrozine than for imidacloprid and spiromesifen in Trialeurodes vaporariorum in greenhouses in Finland? | {
"contexts": [
"Insecticide resistance in Trialeurodes vaporariorum W. is unknown in the species' northern distribution range where it inhabits mainly commercial greenhouses. Resistance development in whiteflies feeding on year-round crops in greenhouses is possible owing to the use of chemical treatments to bac... | High variation in resistance levels to pymetrozine among populations within natural whitefly dispersal limits reflects variation in the usage of this compound among individual greenhouse crop producers. Thus, resistance management is recommended at the individual greenhouse crop producer level, even in a dense producti... | yes |
24,751,698 | Is premature immunosenescence associated with memory dysfunction in rheumatoid arthritis? | {
"contexts": [
"Rheumatoid arthritis (RA) has been associated with premature immunosenescence and an increased prevalence of age-related morbidities including poor cognitive function.",
"We explored the relationships among lymphocyte subsets and memory in RA.",
"Thirty patients with RA and 19 age-matched... | RA patients had reduced memory performance compared to healthy controls. Expansion of activated and senescence-associated T cells was correlated with poor memory performance. | yes |
24,751,699 | Do gram negative wound infection in hospitalised adult burn patients -- systematic review and metanalysis-? | {
"contexts": [
"Gram negative infection is a major determinant of morbidity and survival. Traditional teaching suggests that burn wound infections in different centres are caused by differing sets of causative organisms. This study established whether Gram-negative burn wound isolates associated to clinical woun... | Gram-negative infections predominate in burn surgery. This study is the first to establish that burn wound infections do not differ significantly between burn centres. It is the first study to report the pathogens responsible for the majority of Gram-negative infections in these patients. Whilst burn wound infection is... | yes |
24,775,098 | Is lower potassium intake associated with increased wave reflection in young healthy adults? | {
"contexts": [
"Increased potassium intake has been shown to lower blood pressure (BP) even in the presence of high sodium consumption however the role of dietary potassium on vascular function has received less attention. The aim of this study was to evaluate the relationship between habitual intake of sodium (... | These data suggest that lower potassium intakes are associated with greater wave reflection and stiffer arteries in young healthy adults. | yes |
24,745,554 | Does latino children 's body mass index at 2-3.5 years predict sympathetic nervous system activity at 5 years? | {
"contexts": [
"To understand whether the relationship between young children's autonomic nervous system (ANS) responses predicted their BMI, or vice versa, the association between standardized BMI (zBMI) at 2, 3.5, and 5 years of age and ANS reactivity at 3.5-5 years of age, and whether zBMI predicts later ANS ... | Increased zBMI early in childhood may dampen young children's SNS responses later in life. | yes |
24,760,054 | Is leg extension power a pre-disaster modifiable risk factor for post-traumatic stress disorder among survivors of the Great East Japan Earthquake : a retrospective cohort study? | {
"contexts": [
"Post-traumatic stress disorder (PTSD) is a common psychological problem following natural disasters. Although pre-disaster risk factors are important for early detection and proactive support, the examination of such has been limited to sociodemographic factors, which were largely unaffected by t... | Leg extension power is a potentially modifiable pre-disaster risk factor among men for attenuating the severity of PTSD symptoms associated with great disasters such as the Great East Japan Earthquake among men. | yes |
24,760,053 | Does imbalance between pro and anti-oxidant mechanisms in perivascular adipose tissue aggravate long-term high-fat diet-derived endothelial dysfunction? | {
"contexts": [
"The hypothesis of this study is that long-term high-fat diets (HFD) induce perivascular adipose tissue (PVAT) dysfunction characterized by a redox imbalance, which might contribute to aggravate endothelial dysfunction in obesity.",
"C57BL/6J mice were fed either control or HFD (45% kcal from ... | We suggest that the imbalance between pro-oxidant (NOX, superoxide anions, hydrogen peroxide) and anti-oxidant (eNOS, NO, ecSOD, GSSG) mechanisms in PVAT after long-term HFD might contribute to the aggravation of endothelial dysfunction. | yes |
24,757,105 | Do serial montreal cognitive assessments demonstrate reversible cognitive impairment in patients with acute transient ischemic attack and minor stroke? | {
"contexts": [
"Cognitive changes after ischemic stroke are often overlooked, particularly acutely and in patients with mild or transient deficits. We assessed patients with transient ischemic attack (TIA)/minor stroke with serial cognitive screening tests. We tested the hypothesis that mild acute deficits are t... | Acute temporary cognitive impairment after TIA/minor stroke is common. The MoCA is sensitive to these changes, but the MMSE is not. Routine cognitive assessment after TIA/minor stroke may be warranted and relevant to return to activities even when other neurological deficits are not evident. | yes |
24,752,885 | Does hyperintense cortical signal on magnetic resonance imaging reflect focal leukocortical encephalitis and seizure risk in progressive multifocal leukoencephalopathy? | {
"contexts": [
"To determine the frequency of hyperintense cortical signal (HCS) on T1-weighted precontrast magnetic resonance (MR) images in progressive multifocal leukoencephalopathy (PML) patients, its association with seizure risk and immune reconstitution inflammatory syndrome (IRIS), and its pathologic cor... | Seizures are a frequent complication in PML. HCS is associated with seizures and IRIS, and correlates histologically with JCV focal leukocortical encephalitis. | yes |
24,763,120 | Do `` Pleats fold '' technique of amniotic membrane transplantation for management of corneal perforations? | {
"contexts": [
"The aim of this study was to examine the efficacy and surgical success rates of amniotic membrane (AM) transplantation performed for corneal perforation closure using a novel technique.",
"This study included 6 eyes from 6 patients with corneal perforation who had received AM transplantation ... | The AM transplantation procedure may be an effective option for treating corneal perforations when the wound is circular or irregular, except for incised wounds. Our "Pleats Fold" AM transplantation technique can achieve definite closure and effectively repair wounds of various sizes. Postoperative astigmatic values we... | yes |
24,746,502 | Does change in health-related quality of life in patients with coronary artery disease predict 4-year mortality? | {
"contexts": [
"Self-reported health-related quality of life (HRQL) and changes in HRQL have been shown to predict mortality and/or adverse events in patients with coronary artery disease. MacNew Heart Disease HRQL questionnaire scores were examined as predictors of 4-year all-cause mortality.",
"Following r... | A deterioration of ≥0.50 points in MacNew HRQL Global scores at both one and three months is predictive of 4-year all-cause mortality. Serial HRQL information may be useful to identify patients at higher risk for adverse cardiac events and mortality and may have implications for determining follow-up frequency and trea... | yes |
24,770,349 | Does severe and morbid obesity ( BMI ≥ 35 kg/m ( 2 ) ) increase surgical time and length of hospital stay in total knee arthroplasty surgery? | {
"contexts": [
"Certain aspects of total knee arthroplasty (TKA) in severely and morbidly obese (SMO) patients (BMI ≥ 35 kg/m(2)) remain controversial. This study aimed to assess the duration of TKA surgery and hospital stay in relation to patients' BMI.",
"Three operative times during TKA surgery were recor... | Severely and morbidly obese (SMO) patients (BMI ≥ 35 kg/m(2)) undergoing TKA surgery do not require longer operative time or hospital stay than non-obese or obese Class I patients. The fact that surgical time was not significantly different could be due to greater specialisation in the treatment of these patients, whic... | no |
24,755,434 | Do gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection? | {
"contexts": [
"While inflammation predicts mortality in treated human immunodeficiency virus (HIV) infection, the prognostic significance of gut barrier dysfunction and phenotypic T-cell markers remains unclear.",
"We assessed immunologic predictors of mortality in a case-control study within the Longitudin... | Gut epithelial barrier dysfunction, innate immune activation, inflammation, and coagulation-but not T-cell activation, senescence, and exhaustion-independently predict mortality in individuals with treated HIV infection with a history of AIDS and are viable targets for interventions. | yes |
24,755,435 | Does vitamin D deficiency promote epithelial barrier dysfunction and intestinal inflammation? | {
"contexts": [
"Vitamin D, an important modulator of the immune system, has been shown to protect mucosal barrier homeostasis. This study investigates the effects of vitamin D deficiency on infection-induced changes in intestinal epithelial barrier function in vitro and on Citrobacter rodentium-induced colitis i... | This study demonstrates that vitamin D is an important mediator of intestinal epithelial defenses against infectious agents. Vitamin D deficiency predisposes to more-severe intestinal injury in an infectious model of colitis. | yes |
24,773,499 | Does novel individual metabolic profile characterize the protein kinase B-alpha ( pkbα-/- ) in vivo model? | {
"contexts": [
"Type 2 diabetes and associated co-morbidities run epidemic waves worldwide. Since pathophysiological constellations are individual and display a wide spread of dysmetabolic profiles personalized health care assessments start to emerge. Therefore, we established a specific in silico assessment too... | Specific metabolic characterization should be assessed individually. Therefore, our in silico model enables novel insights inaugurating specific primary preventive strategies targeting individual metabolic profiling precisely. | yes |
24,769,306 | Does pPARγ activation affect endothelin activity in non-diabetic patients with hypertension or hypercholesterolemia? | {
"contexts": [
"This study tested the hypothesis that pioglitazone reduces endothelin-1 activity in the forearm vasculature in non-diabetic patients with hypertension or hypercholesterolemia and variable degrees of insulin resistance.",
"We conducted a single center, randomized, double-blind, placebo control... | In non-diabetic patients with hypertension or hypercholesterolemia, pioglitazone improves insulin sensitivity, lipid profile, and inflammation but does not affect endothelin activity. Our data suggest that the determinants of endothelin-1 vascular activity in vivo may differ and/or be more complex than those suggested ... | no |
24,771,555 | Does real-time magnetic resonance assessment of septal curvature accurately track acute hemodynamic changes in pediatric pulmonary hypertension? | {
"contexts": [
"This study assesses the relationship between septal curvature and mean pulmonary artery pressure and indexed pulmonary vascular resistance in children with pulmonary hypertension. We hypothesized that septal curvature could be used to estimate right ventricular afterload and track acute changes i... | Septal curvature metrics are able to estimate right ventricular afterload and track acute changes in pulmonary hemodynamics during vasodilator testing. This suggests that septal curvature could be used for continuing assessment of load in pulmonary hypertension. | yes |
24,775,615 | Is systolic volume index by Doppler echocardiography an useful marker for stratification and prognostic evaluation in patients with severe aortic stenosis and preserved ejection fraction? | {
"contexts": [
"The prognosis of patients with severe aortic stenosis, low aortic gradient and preserved ejection fraction is controversial. Our study analyzed the prognosis of these patients and its relation to pressure gradient and aortic valve flow.",
"We performed a retrospective cohort study of 363 cons... | Patients with severe aortic stenosis, normal ejection fraction and low aortic flow have a worse prognosis. Analysis of aortic flow by Doppler echocardiography is useful in risk stratification and therapeutic decision-making in patients with aortic stenosis. | yes |
24,762,635 | Does eprosartan improve cardiac function in swine working heart model of ischemia-reperfusion injury? | {
"contexts": [
"Eprosartan is an angiotensin II receptor antagonist used as an antihypertensive. We sought to evaluate the regional effect of Eprosartan on postinfarct ventricular remodeling and myocardial function in an isolated swine working heart model of ischemia-reperfusion injury.",
"22 swine hearts we... | Pre-treatment with Eprosartan is associated with a significant improvement in regional cardiac function under ischemic conditions. Pharmacological treatment with eprosartan may exert a direct cardioprotective effect on ischemic myocardium. | yes |
24,766,772 | Does development and evaluation of a novel contamination device that target multiple life-stages of Aedes aegypti? | {
"contexts": [
"The increasing global threat of Dengue demands new and easily applicable vector control methods. Ovitraps provide a low-tech and inexpensive means to combat Dengue vectors. Here we describe the development and optimization process of a novel contamination device that targets multiple life-stages ... | This ovitrap is a promising new tool in the battle against Dengue. It has proven to be attractive to Aedes aegypti mosquitoes and effective in contaminating these with Beauveria bassiana. Furthermore, we show that the larvicide pyriproxyfen is successfully disseminated to breeding sites close to the trap. Its low produ... | yes |
24,757,631 | Do qT Dispersion and T Wave Peak-to-end Interval Dispersion in Children with Kawasaki Disease? | {
"contexts": [
"The main complication of Kawasaki disease is the Coronary Artery (CA) involvement and long term follow up of patients depends on the severity of coronary arterial aneurysms, ischemia, and thrombosis. Early diagnosis of these complications can lead to a more desirable outcome for patients. Myocard... | In conclusion, the QT interval (corrected or non-corrected) and the Tp-Te dispersion significantly increased in the patients with KD which shows repolarization changes during the acute phase of KD. However, there is no correlation between the QT interval and the coronary involvement. | yes |
24,749,685 | Does kidney biopsy result versus clinical parameters on mortality and ESRD progression in 2687 patients with glomerulonephritis? | {
"contexts": [
"Physicians refer proteinuric patients to kidney biopsy in order to clarify the issue of underlying renal disease. We compared kidney biopsy results with classical outcome parameters in a large cohort of patients with biopsy proven glomerulonephritis (GN).",
"In a retrospective analysis, 2687 ... | Our study demonstrates histological diagnosis of GN and its specific subtype predicts patient survival and dialysis incidence. Therefore, kidney biopsy should be an integral part of routine diagnostic assessment in patients with any forms of suspected GN. | yes |
24,758,163 | Does visual gene-network analysis reveal the cancer gene co-expression in human endometrial cancer? | {
"contexts": [
"Endometrial cancers (ECs) are the most common form of gynecologic malignancy. Recent studies have reported that ECs reveal distinct markers for molecular pathogenesis, which in turn is linked to the various histological types of ECs. To understand further the molecular events contributing to ECs ... | The results of this study provide a powerful biomarker discovery platform to better understand the progression of ECs and to uncover potential therapeutic targets in the treatment of ECs. This information might lead to improved monitoring of ECs and resulting improvement of treatment of ECs, the 4th most common of canc... | yes |
24,750,253 | Is elevated mean platelet volume associated with silent cerebral infarction? | {
"contexts": [
"The presence of silent cerebral infarction (SCI) increases the risk of transient ischaemia attack, symptomatic stroke, cardiovascular disease and dementia. Mean platelet volume (MPV) is a surrogate marker of activated platelets and is considered a link between inflammation and thrombosis. In addi... | MPV is a novel index for SCI regardless of classical cardiovascular risk factors. | yes |
24,754,148 | Do [ Clinical apprehension on application of Tri-lock BPS total hip arthroplasty ]? | {
"contexts": [
"To study short-term results and clinical application of Tri-lock BPS in total hip arthoplasty.",
"From May 2010 to July 2011, 32 hips in 31 patients (18 males and 13 females, ranging in age from 50 to 77 years old, with an average of 60.5 years old) were treated by total hip arthroplasty with... | Short-term results show that the design of Tri-lock BPS is more in line with human anatomy, and has the advantages in rapid recovery of hip function and retains more bone mass. It offers a newly valuable technology for the treatment of osteonecrosis, femoral neck fracture and DDH and so on. | yes |
24,756,936 | Is a CD8 T cell/indoleamine 2,3-dioxygenase axis required for mesenchymal stem cell suppression of human systemic lupus erythematosus? | {
"contexts": [
"Allogeneic mesenchymal stem cells (MSCs) exhibit therapeutic effects in human autoimmune diseases such as systemic lupus erythematosus (SLE), but the underlying mechanisms remain largely unknown. The aim of this study was to investigate how allogeneic MSCs mediate immunosuppression in lupus patie... | We found a previously unrecognized CD8+ T cell/IFNγ/IDO axis that mediates the therapeutic effects of allogeneic MSCs in lupus patients. | yes |
24,768,130 | Is it all in the factors : effects of cognitive remediation on symptom dimensions? | {
"contexts": [
"Cognitive remediation (CR) aims primarily to improve cognition and functional outcomes. However, a limited number of studies reported a positive effect on symptoms. This limited effect may be because the symptom clusters considered are too broad and heterogeneous. This study explores, for the fir... | CR can have not only a positive effect on disorganisation but also on negative symptoms. Using detailed symptom dimensions can characterise more accurately the effect of CR on symptom of schizophrenia. | yes |
24,747,454 | Is recovery of fibrinogen concentrate after intraosseous application equivalent to the intravenous route in a porcine model of hemodilution? | {
"contexts": [
"Fibrinogen concentrate is increasingly considered as a hemostatic agent for trauma patients experiencing bleeding. Placing a venous access is sometimes challenging during severe hemorrhage. Intraosseous access may be considered instead. Studies of intraosseous infusion of coagulation factor conce... | This study suggests that intraosseous administration of fibrinogen concentrate results in a recovery of fibrinogen similar to that of intravenous administration. The intraosseous route of fibrinogen concentrate could be a valuable alternative in situations where intravenous access is not feasible or would be time consu... | yes |
24,748,159 | Are men traveling away from home more likely to bring malaria into high altitude villages , northwest Ethiopia? | {
"contexts": [
"Information about malaria risk factors at high altitudes is scanty. Understanding the risk factors that determine the risk of malaria transmission at high altitude villages is important to facilitate implementing sustainable malaria control and prevention programs.",
"An unmatched case contro... | Travel outside of their home was an important risk of malaria infections acquisition. Targeting males who frequently travel to malarious areas can reduce malaria transmission risks in high altitude areas. | yes |
24,758,297 | Does breast tumor specific mutation in GATA3 affect physiological mechanisms regulating transcription factor turnover? | {
"contexts": [
"The transcription factor GATA3 is a favorable prognostic indicator in estrogen receptor-α (ERα)-positive breast tumors in which it participates with ERα and FOXA1 in a complex transcriptional regulatory program driving tumor growth. GATA3 mutations are frequent in breast cancer and have been clas... | We propose that this specific, cancer-derived mutation in GATA3 deregulates physiologic protein turnover, stabilizes GATA3 binding across the genome and modulates the response of breast cancer cells to estrogen signaling. | yes |
24,758,291 | Does e2F3a gene expression have prognostic significance in childhood acute lymphoblastic leukemia? | {
"contexts": [
"To study E2F3a expression and its clinical significance in children with acute lymphoblastic leukemia (ALL).",
"We quantified E2F3a expression at diagnosis in 148 children with ALL by real-time PCR. In the test cohort (n = 48), receiver operating characteristic (ROC) curve was used to find th... | Low expression of E2F3a was associated with inferior prognosis in childhood ALL. An algorithm composed of E2F3a expression and MRD could predict relapse or induction failure more precisely than that of the current risk stratification. | yes |
24,778,013 | Does neamine inhibit oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation? | {
"contexts": [
"Angiogenin undergoes nuclear translocation and stimulates ribosomal RNA transcription in both endothelial and cancer cells. Consequently, angiogenin has a dual effect on cancer progression by inducing both angiogenesis and cancer cell proliferation. The aim of this study was to assess whether nea... | Neamine effectively inhibits oral cancer progression through inhibition of tumor angiogenesis. Neamine also directly inhibits proliferation of certain types of oral cancer cells. Therefore, neamine has potential as a lead compound for oral cancer therapy. | yes |
24,778,018 | Is overexpression of NOTCH-regulated ankyrin repeat protein associated with breast cancer cell proliferation? | {
"contexts": [
"NOTCH-regulated ankyrin repeat protein (NRARP) has been implicated in crosstalk between NOTCH and wingless-type mouse mammary tumor virus integration site (WNT) signals during development. Our study aimed to clarify its role in breast cancer cells.",
"Public microarray data were used to analy... | NRARP may stimulate cell proliferation in human breast cancer. | yes |
24,752,832 | Does macular pigment optical density measurements by one-wavelength reflection photometry -- influence of cataract surgery on the measurement result? | {
"contexts": [
"The main objective of the present study was the investigation of possible influence of lens opacification on macular pigment optical density (MPOD) measurements.",
"Eighty-six eyes of 64 patients (mean age 73.4 ± 8.3 years) were included in the study. MPOD was prospectively measured using the... | As established by comparison of pre- to post-operative measurements, cataract presented a strong effect on MPOD measured by one-wavelength reflection method. Particular care should therefore be taken when evaluating MPOD using this method in elderly patients with progressed stage of cataract. Future optimization of cor... | yes |
24,755,233 | Does antioxidant effect of Phyllanthus emblica extract prevent contrast-induced acute kidney injury? | {
"contexts": [
"Contrast-induced acute kidney injury (CI-AKI) occurs after the administration of intravenous iodinated contrast agents. Oxidative stress has been proposed as one of the most important mechanisms in the pathogenesis of CI-AKI. The objective of this study was to investigate the antioxidant effect o... | This study demonstrated the protective role of PE extract against CI-AKI. | yes |
24,755,231 | Is nQO1 gene rs1800566 variant associated with risk for multiple sclerosis? | {
"contexts": [
"A possible role of oxidative stress in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis has been suggested. The detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1) has been found up-regulated in MS lesions. A previous report described an assoc... | Our results indicate that NQO1 rs1800566 does not have an effect on MS disease risk. | no |
24,754,543 | Does cD4 count outperform World Health Organization clinical algorithm for point-of-care HIV diagnosis among hospitalised HIV-exposed Malawian infants? | {
"contexts": [
"To determine, for the WHO algorithm for point-of-care diagnosis of HIV infection, the agreement levels between paediatricians and non-physician clinicians, and to compare sensitivity and specificity profiles of the WHO algorithm and different CD4 thresholds against HIV PCR testing in hospitalised... | Performance by the WHO algorithm and CD4 thresholds resulted in many misclassifications. Point-of-care CD4 thresholds of <1500 cells/mm(3) or <2000 cells/mm(3) could identify more HIV-infected infants with fewer false positives than the algorithm. However, a point-of-care option with better performance characteristics ... | yes |
24,755,784 | Do gNAS gene variants affect β-blocker-related survival after coronary artery bypass grafting? | {
"contexts": [
"Cardiac overexpression of the β-adrenoreceptor (βAR)-coupled stimulatory G-protein subunit Gαs enhances inotropic responses to adrenergic stimulation and improves survival in mice under βAR blockade. The authors recently identified three common haplotypes in the GNAS gene encoding Gαs, with the g... | GNAS haplotypes independently associate with an increased risk of death after primary coronary artery bypass graft surgery. These results are most pronounced in patients receiving βAR blockers, strengthening the rationale for personalized treatment, to decrease medication side effects and improve outcomes. | yes |
24,747,446 | Is complex penetrating duodenal injuries : less better? | {
"contexts": [
"The traditional management of complex penetrating duodenal trauma (PDT) has been the use of elaborate temporizing and complex procedures such as the pyloric exclusion and duodenal diverticulization. We sought to determine whether a simplified surgical approach to the management of complex PDT inj... | An application of basic damage-control techniques for PDT leads to improved survival and an acceptable incidence of complications. | yes |
24,756,254 | Are γ-H2AX foci increased in lymphocytes in vivo in young children 1 h after very low-dose X-irradiation : a pilot study? | {
"contexts": [
"Computed tomography (CT) is an imaging modality involving ionizing radiation. The presence of γ-H2AX foci after low to moderate ionizing radiation exposure has been demonstrated; however it is unknown whether very low ionizing radiation exposure doses from CT exams can induce γ-H2AX formation in ... | We found a significant induction of γ-H2AX foci in lymphocytes from post-CT samples of three very young children. When possible, CT exams should be limited or avoided by possibly applying non-ionizing radiation exposure techniques such as US or MRI. | yes |
24,751,706 | Is target weight gain during the first year of hemodialysis therapy associated with patient survival? | {
"contexts": [
"Hemodialysis (HD) patients are exposed to a high risk of death. Nutritional status has been recognized as a key factor for patient survival. Nutritional markers have been shown to improve after HD onset. In this study we have analyzed the dynamics of target weight (TGW) change and the evolution o... | The initial fluid removal was related to nutritional markers. The secondary TGW change during the first year of HD treatment calculated after the initial phase of fluid removal was identified as a strong predictor of survival. It was associated with a better food intake whereas the patient case mix was not different. T... | yes |
24,748,674 | Do amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease? | {
"contexts": [
"To examine whether β-amyloid (Aβ) and APOE ε4 status independently contribute or interact to influence longitudinal cognitive decline in clinically normal older individuals (CN).",
"Data from 490 CNs were aggregated across 3 observational cohort studies (Harvard Aging Brain Study, Alzheimer's... | Clinically normal individuals who are APOE ε4+ and have high Aβ showed the highest cognitive decline. These results suggest that Aβ and APOE ε4 are not redundant contributors of decline in aging but rather interact to promote decline during the short follow-up period examined in this study. Longer follow-up periods wil... | yes |
24,758,269 | Does hedgehog/Gli promote epithelial-mesenchymal transition in lung squamous cell carcinomas? | {
"contexts": [
"Squamous cell carcinomas (SCC) account for approximately 30% of non-small cell lung cancer. Investigation of the mechanism of invasion and metastasis of lung SCC will be of great help for the development of meaningful targeted therapeutics. This study is intended to understand whether the activat... | Our results suggested that the Shh/Gli pathway may be critical for lung SCC recurrence, metastasis and resistance to chemotherapy. Inhibition of the Shh/Gli pathway activity/function is a potential therapeutic strategy for the treatment of lung SCC patients. | yes |
24,745,729 | Is clinical success of intrauterine insemination cycles affected by the sperm preparation time? | {
"contexts": [
"To determine the impact of the time interval from the end of sperm preparation (TSP) to intrauterine insemination (IUI) on the outcome.",
"Prospective multicentre cohort study.",
"Seven French centers (assisted reproduction group in northeastern France, four academic centers, and three cl... | The observance of TSP in the range of 40-80 minutes has a potential positive effect on pregnancy rate, while not requiring the investment of supplemental resources. This finding awaits confirmation in randomized trials. | yes |
24,778,792 | Is cycling performance decrement greater in hypobaric versus normobaric hypoxia? | {
"contexts": [
"The purpose of this study was to determine whether cycling time trial (TT) performance differs between hypobaric hypoxia (HH) and normobaric hypoxia (NH) at the same ambient PO2 (93 mmHg, 4,300-m altitude equivalent).",
"Two groups of healthy fit men were matched on physical performance and d... | Cycling time trial performance is impaired to a greater degree in HH versus NH at the same ambient PO2 equivalent to 4,300 m despite similar cardiorespiratory responses. | yes |
24,748,833 | Are free-fatty-acid-regulating effects of fermented red ginseng mediated by hormones and by the autonomic nervous system? | {
"contexts": [
"Understanding what causes changes in the flux of free fatty acids (FFA) is important to elucidate the etiology of metabolic syndrome. The first aim of this study was to test whether or not hormones and the autonomic nervous system influence blood FFA levels. A secondary aim was to test by means o... | The path coefficients of cortisol and the branchial pulse for FFA were significantly different between the FRG group and the placebo group. | yes |
24,764,083 | Do impact of electrode design and surgical approach on scalar location and cochlear implant outcomes? | {
"contexts": [
"Three surgical approaches: cochleostomy (C), round window (RW), and extended round window (ERW); and two electrodes types: lateral wall (LW) and perimodiolar (PM), account for the vast majority of cochlear implantations. The goal of this study was to analyze the relationship between surgical appr... | These data suggest that RW and ERW approaches and LW electrodes are associated with an increased likelihood of successful ST placement. Furthermore, electrode position entirely within the ST confers superior audiological outcomes. | yes |
24,751,410 | Are baseline metabolic tumor volume and total lesion glycolysis associated with survival outcomes in patients with locally advanced pancreatic cancer receiving stereotactic body radiation therapy? | {
"contexts": [
"Although previous studies have demonstrated the prognostic value of positron emission tomography (PET) parameters in other malignancies, the role of PET in pancreatic cancer has yet to be well established. We analyzed the prognostic utility of PET for patients with locally advanced pancreatic can... | Pre-SBRT MTV and TLG are potential predictive factors for overall survival in patients with LAPC and may assist in tailoring therapy. | yes |
24,757,137 | Is reverse interferon signature characteristic of antigen-presenting cells in human and rat spondyloarthritis? | {
"contexts": [
"In HLA-B27-transgenic rats, the development of a disorder that mimics spondyloarthritis (SpA) is highly correlated with dendritic cell (DC) dysfunction. The present study was undertaken to analyze the underlying mechanisms of this via transcriptome analysis.",
"Transcriptome analysis of ex vi... | Our results suggest that expression of HLA-B27 leads to a defect in IFNγ signaling in antigen-presenting cells in both B27-transgenic rats and SpA patients, which may result in Th17 expansion and Treg cell alteration (as shown in B27-transgenic rats) and contribute to disease pathogenesis. | yes |
24,757,136 | Does inactivation of patched1 in murine chondrocytes cause spinal fusion without inflammation? | {
"contexts": [
"During development of the vertebrate skeleton, chondrocytes form a cartilage template that is gradually replaced by bone. Hormones of the Hedgehog (HH) family have been implicated in the ossification process, but their exact relationship to normal or pathogenic bone formation is unclear. This stu... | Our findings indicate that chronic activation of the HH signal pathway in spinal chondrocytes can trigger an ankylosing spine morphology without immune cell contributions. Hence, the destruction of cartilage and loss of axial joint integrity can result from chondrocyte-intrinsic defects of monogenic origin. | yes |
24,768,808 | Does biofeedback-guided control of abdominothoracic muscular activity reduce regurgitation episodes in patients with rumination? | {
"contexts": [
"Rumination syndrome is characterized by effortless recurrent regurgitation of recently ingested food into the mouth, with consequent expulsion or re-chewing and swallowing. We investigated whether rumination is under volitional control and can be reversed by behavioral treatment.",
"We perfor... | Rumination is produced by an unperceived somatic response to food ingestion that disrupts abdominal accommodation and can be effectively corrected by biofeedback-guided control of abdominothoracic muscular activity. | yes |
24,768,807 | Does paeonol protect against premature senescence in endothelial cells by modulating Sirtuin 1 pathway? | {
"contexts": [
"Paeonol is a phenolic compound isolated mainly from Moutan cortex, root bark of Chinese Peony tree. Moutan cortex holds a significant value in traditional Chinese medicine for alleviating various oxidative stress-related diseases mainly atherosclerosis and myocardial infarction. The present study... | These findings suggest that paeonol protects endothelial cells against oxidative stress-induced premature senescence by modulating the expressions of Sirt1 protein and its substrates. | yes |
24,768,802 | Does kynurenine production mediated by indoleamine 2,3-dioxygenase aggravate liver injury in HBV-specific CTL-induced fulminant hepatitis? | {
"contexts": [
"Indoleamine 2,3-dioxygenase (IDO), an enzyme that is ubiquitously distributed in mammalian tissues and cells, converts tryptophan to kynurenine, and is also known as a key molecule that promotes apoptosis in lymphocytes and neurons. In this study, we established hepatitis B virus (HBV)-transgenic... | Kynurenine and IFN-γ induced by the administration with HBV-specific CTL are cooperatively involved in the progression of liver injury in acute hepatitis model. Our results may lead to a new therapy for the acute liver injury caused by HBV infection. | yes |
24,771,001 | Are mitochondrial SIRT3 and its target glutamate dehydrogenase altered in follicular cells of women with reduced ovarian reserve or advanced maternal age? | {
"contexts": [
"Is the activity of sirtuin 3 (SIRT3) altered in granulosa and cumulus cells from young women with reduced ovarian reserve or women of advanced maternal age?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Adult",
"Anti-Mullerian Hormone",
"Cumulus Cells",
"Female",
"Fe... | SIRT3 mRNA and active protein in granulosa and cumulus cells were decreased in women with reduced ovarian reserve and advanced maternal age. | yes |
24,755,560 | Are human spotted fever group rickettsioses underappreciated in southern Taiwan , particularly for the species closely-related to Rickettsia felis? | {
"contexts": [
"Despite increased identification of spotted fever group rickettsioses (SFGR) in animals and arthropods, human SFGR are poorly characterized in Taiwan.",
"Patients with suspected Q fever, scrub typhus, murine typhus, leptospirosis, and dengue fever from April 2004 to December 2009 were retrosp... | Human SFGR exist and are neglected diseases in southern Taiwan, particularly for the species closely-related to R. felis. | yes |
24,773,072 | Is mitochondrial DNA copy number associated with diagnosis and prognosis of head and neck cancer? | {
"contexts": [
"Mitochondrial DNA (mtDNA) copy number correlates with tumor pathology in some cancers.",
"To investigate mtDNA copy number in head and neck cancer (HNC).",
"mtDNA copy number was determined and compared between HNC patients and malignancy-free controls.",
"The mtDNA copy number was si... | mtDNA copy number appears to be associated with HNC stage and survival, but confirmation requires similar studies in larger cohorts. | yes |
24,747,134 | Is chk1 required for the metaphase-anaphase transition via regulating the expression and localization of Cdc20 and Mad2? | {
"contexts": [
"The checkpoint kinase 1 (Chk1) functions not only in genotoxic stresses but also in normal cell cycle progression, particularly in the initiation, progression and fidelity of unperturbed mitosis. In this study, we investigated the role of Chk1 in regulating the metaphase-anaphase transition in ma... | These results strongly suggest that Chk1 is required for the metaphase-anaphase transition via regulating the subcellular localization and the expression of Cdc20 and Mad2. | yes |
24,747,135 | Does sedum sarmentosum Bunge extract exert renal anti-fibrotic effects in vivo and in vitro? | {
"contexts": [
"Sedum sarmentosum Bunge, a traditional Chinese herbal medicine, has a wide range of clinical effects, including anti-oxidation, anti-inflammation, and anti-cancer properties. In this study, we determined whether S. sarmentosum Bunge Extract (SSBE) has anti-fibrotic effects on renal tissues.",
... | These findings suggest that SSBE may have therapeutic potential for fibrotic kidney diseases. | yes |
24,773,508 | Do neutrophils from allergic asthmatic patients produce and release metalloproteinase-9 upon direct exposure to allergens? | {
"contexts": [
"Asthma is characterized by airway inflammation and remodelling in which matrix metalloproteinases (MMPs) play an important role. MMP-9 is the major MMP found in the bronchoalveolar lavage fluids and bronchial biopsies from patients with allergic asthma after allergen challenge, where it correlate... | These data demonstrate that the exposure of neutrophils to allergens leads to generation of MMP-9, which may then lead to remodelling in asthma. | yes |
24,754,458 | Are c3 and C4 strongly related to adipose tissue variables and cardiovascular risk factors? | {
"contexts": [
"In several reports, C3 and C4 have been linked to diabetes and cardiovascular disease (CVD). Here, we investigate this link and the degree of C3 activation in elderly individuals.",
"In this study, C3 and C4 and the activation fragment C3a-desArg were analysed in 1016 subjects aged 70, in whi... | A strong relation between C3, C4 and C3a-desArg levels, adipose tissue and risk factors of CVD was established. The data support that the adipose tissue produces complement components and generates initiators of inflammation, such as C3a and C5a, able to trigger a cyto/chemokine response, in proportion to the amount of... | yes |
24,751,286 | Does continuous endotracheal tube cuff pressure control system protect against ventilator-associated pneumonia? | {
"contexts": [
"The use of a system for continuous control of endotracheal tube cuff pressure reduced the incidence of ventilator-associated pneumonia (VAP) in one randomized controlled trial (RCT) with 112 patients but not in another RCT with 142 patients. In several guidelines on the prevention of VAP, the use... | The use of a continuous endotracheal cuff pressure control system and/or an endotracheal tube with a lumen for SSD could help to prevent VAP in patients requiring more than 48 hours of mechanical ventilation. | yes |
24,766,152 | Does comparison of not for resuscitation ( NFR ) form across five Victorian health services? | {
"contexts": [
"Within Australian hospitals, cardiac and respiratory arrests result in a resuscitation attempt unless the patient is documented as not for resuscitation.",
"To examine the consistency of policies and documentation for withholding in-hospital resuscitation across health services.",
"An obs... | NFR forms should be reviewed and standardised so as to be clear, uniform and consistent with the legislative framework. We propose a two-stage process of documentation. Stage 1 facilitates discussion of patient-specific goals of care and consideration of limitations of treatment. Stage 2 serves to communicate a NFR ord... | yes |
24,766,907 | Does thorax irradiation trigger a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells? | {
"contexts": [
"Lymphocyte infiltration is a common feature of radiation-induced pneumonitis and fibrosis, but their contribution to the pathogenic processes is still unclear. Here, we addressed the impact of thorax irradiation on the T cell compartment with a focus on immunosuppressive regulatory T cells (Treg)... | The response of the adaptive immune system to whole thorax irradiation is characterized by local immunoactivation and systemic immunosuppression. The transient accumulation of immunosuppressive CD4+ FoxP3+ Treg may be required to protect the lung against excessive inflammation-induced tissue damage. Further investigati... | yes |
24,746,137 | Does tRIB3 alter endoplasmic reticulum stress-induced β-cell apoptosis via the NF-κB pathway? | {
"contexts": [
"To examine the effect of TRIB3 on endoplasmic reticulum stress induced β-cell apoptosis and to investigate the mechanism with a specific emphasis on the role of NF-κB pathway.",
"We investigated the effect of TRIB3 on ER stress-induced β-cell apoptosis in INS-1 cells and primary rodent islets... | TRIB3 mediated ER stress-induced β-cell apoptosis via the NF-κB pathway. | yes |
24,756,175 | Is additional surgical procedure a risk factor for surgical site infections after laparoscopic cholecystectomy? | {
"contexts": [
"Surgical site infections (SSI) are associated with increased costs and length of hospital stay, readmission rates, and mortality. The aim of this study was to identify risk factors for SSI in patients undergoing laparoscopic cholecystectomy.",
"Analysis of 35,432 laparoscopic cholecystectomie... | Additional surgical procedure was identified as a strong risk factor for SSI after laparoscopic cholecystectomy. Furthermore, operation time >60 min, age >55 years, conversion to open procedure, cystic stump insufficiency, postoperative hematoma, gallbladder perforation, gallbladder empyema, or surgical revision were i... | yes |
24,759,965 | Is cannulation time a more accurate measure of cannulation difficulty in endoscopic retrograde cholangiopancreatography than the number of attempts? | {
"contexts": [
"Cannulation of the common bile duct (CBD) is the initial and sometime challenging step in endoscopic retrograde cholangiopancreatography (ERCP) procedure. Endoscopists often use cannulation attempts and cannulation time to grade cannulation difficulty, but a standard system has yet to be establis... | The grade of cannulation difficulty for a given ERCP procedure may differ when different methods are used (total cannulation time vs number of attempts); thus, grading by different methods should not be used interchangeably. Cannulation time is a more objective and more accurate assessment tool for grading cannulation ... | yes |
24,762,556 | Does taurolidine specifically inhibit growth of neuroblastoma cell lines in vitro? | {
"contexts": [
"Neuroblastoma is a common pediatric solid tumor with poor outcome for metastatic disease. Thus, novel therapeutic options are of main interest. The anti-neoplastic properties of taurolidine have been demonstrated on a variety of human cancer cells. However, data on neuroblastoma is lacking. There... | The observed negative impact on cell growth, highly distinctive in SK-N-BE(2)-M17 and SK-N-SH, implies a taurolidine-specific mode of action that appears dependent on differences on cellular and molecular level. Further investigations are warranted to evaluate its mechanism and probable clinical use. | yes |
24,766,791 | Does humeral windows and longitudinal split for component removal in revision shoulder arthroplasty? | {
"contexts": [
"Removal of a humeral component during revision shoulder arthroplasty can be difficult. If the component cannot be extracted from above, an alternative approach may compromise bone integrity. Two potential solutions are a humeral window and a longitudinal split. This review was performed to determ... | In both groups, there were no cases of malunion or clinical loosening. These data suggest that windows and longitudinal splits facilitate controlled removal of well-fixed components with high rate of union and low rate of intraoperative or postoperative sequelae. | yes |
24,777,168 | Do common variants on 9p21.3 are associated with brain arteriovenous malformations with accompanying arterial aneurysms? | {
"contexts": [
"To investigate whether previously reported 9p21.3 single nucleotide polymorphisms (SNPs) are associated with risk of brain arteriovenous malformations (BAVM), which often have accompanying arterial aneurysms. Common variants in the 9p21.3 locus have been reported to be associated with multiple ca... | Common 9p21.3 variants showed similar effect sizes for association with BAVM as previously reported for aneurysmal disease. The association with BAVM appears to be explained by known associations with aneurysms, suggesting that BAVM-associated aneurysms share similar vascular pathology mechanisms with other aneurysm ty... | yes |
24,767,563 | Does intracanal delivery of Resolvin E1 control inflammation in necrotic immature rat teeth? | {
"contexts": [
"Pulp necrosis in immature teeth and the resulting periodontal apical inflammation negatively affect root formation. Resolvin E1 (RvE1) is a lipid-derived endogenous pro-resolution molecule that controls inflammation. The aim of this investigation was to evaluate the impact of RvE1 applied as an i... | RvE1 and TAP had a positive impact on reducing inflammation and promoting root formation. RvE1 was more effective in reducing inflammation at earlier stages. RvE1 has potential to be used as root canal dressing to control inflammation in endodontically compromised teeth before complete root formation. Stability of RvE1... | yes |
24,763,164 | Does limited evidence suggest standard fluoride toothpaste reduces caries potential in preschool children? | {
"contexts": [
"CENTRAL, Medline, Embase, Web of Science, LILACS and BBO databases, the Brazilian database of thesis and dissertations (Banco de Teses CAPES), a Brazilian register of ethically approved projects involving human beings (SISNEP) and two registers of ongoing trials (Current Controlled Trials and Cli... | Standard F toothpastes are effective in reducing dental caries in the primary teeth of preschool children and thus their use should be recommended to this age group. | yes |
24,774,438 | Does activation of peroxisome proliferator-activated receptor β/δ attenuate acute ischemic stroke on middle cerebral ischemia occlusion in rats? | {
"contexts": [
"Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the nuclear hormone receptor family. There is little information about the effects of the immediate administration of specific ligands of PPAR-β/δ (GW0742) in animal models of acute ischemic stroke. Us... | The study suggests the neuroprotective effect of the PPAR-β/δ ligand GW0742 in acute ischemic stroke by a mechanism that may involve its anti-inflammatory and antiapoptotic action. | yes |
24,754,551 | Does serum high-mobility group box 1 protein correlate with cognitive decline after gastrointestinal surgery? | {
"contexts": [
"Accumulating evidence has indicated that inflammation may act as a potential mechanism underlying post-operative cognitive dysfunction (POCD). High-mobility group box 1 (HMGB1), as a known late mediator of inflammation, is involved in the development of post-operative complications. Thus, we soug... | Serum HMGB1 and IL-6 levels increase significantly after major gastrointestinal surgery in elderly patients and such elevations are associated with the occurrence of cognitive decline after surgery. | yes |
24,748,519 | Is adenovirus species C associated with chronic suppurative lung diseases in children? | {
"contexts": [
"The role of human adenoviruses (HAdVs) in chronic respiratory disease pathogenesis is recognized. However, no studies have performed molecular sequencing of HAdVs from the lower airways of children with chronic endobronchial suppuration. We thus examined the major HAdV genotypes/species, and rela... | HAdV-C is the major HAdV species detected in the lower airways of children with PBB and BE. Younger age appears to be an important risk factor for HAdV(+) of the lower airways and influences the likelihood of bacterial coinfection. | yes |
24,752,459 | Does severe leukoaraiosis portend a poor outcome after traumatic brain injury? | {
"contexts": [
"It is now well accepted that traumatic white matter injury constitutes a critical determinant of post-traumatic functional impairment. However, the contribution of preexisting white matter rarefaction on outcome following traumatic brain injury (TBI) is unknown. Hence, we sought to determine whet... | We provide first evidence that preexisting cerebral small vessel disease independently predicts a poor functional outcome after closed head TBI. This association is independent of other established outcome predictors such as age, comorbid state as well as intensive care unit complications and interventions. This knowle... | yes |
24,774,753 | Is home death associated with frequency of physician home medical care visits : a questionnaire survey on communications in home medical care settings? | {
"contexts": [
"To investigate the factors related to communications in home medical care settings, and the association between such factors and a patient's place of death.",
"A questionnaire survey of 295 families of patients who had previously received home medical care was carried out in June and July 201... | The frequency of doctor home-visits was the only factor identified that was positively associated with the occurrence of home death in home medical care settings. | yes |
24,769,395 | Does peptide XIB13 reduce capillary leak in a rodent burn model? | {
"contexts": [
"Edema due to capillary leak is a generalized and life threatening event in sepsis and major burns for which there is no causal treatment. Local burn wounds are an ideal model to investigate the impact of a new therapeutic agent on edema formation. We aimed to identify peptide sequences of cinguli... | Xib13 improved angiogenesis, reduced edema formation and showed no side effects on other physiological parameters. Since edema formation is a serious parameter for burn conversion and is associated with survival it could provide a new treatment option for patients with burn injuries. | yes |
24,748,337 | Does overexpression of long noncoding RNA HOTAIR predict a poor prognosis in patients with cervical cancer? | {
"contexts": [
"The long noncoding RNA HOTAIR has been reported to be a good biomarker for poor prognosis in a variety of human cancers. However, whether HOTAIR could serve as novel biomarker to predict prognosis in cervical cancer or not is unknown. The aim of the present study was to examine the expression of ... | our data indicate that high expression of HOTAIR is involved in cervical cancer progression and could be a potential target for diagnosis and gene therapy. | yes |
24,776,095 | Is lPA rs10455872 polymorphism associated with coronary lesions in Brazilian patients submitted to coronary angiography? | {
"contexts": [
"Polymorphisms in the LPA gene were associated with coronary artery disease (CAD). However, there are differences in the allelic frequencies, Lp(a) levels, and significant association with CAD according to ethnic groups. In this scenario, the main aim of this study was to assess the influence of t... | We confirmed the association of the LPA rs10455872 with CAD in a large sample of Brazilian patients. For the LPA rs3798220, our finding is consistent with studies which showed the lack of this genetic association. | yes |
24,767,355 | Is the ratio of plasma interleukin-18 a sensitive biomarker for acute kidney injury after liver transplantation? | {
"contexts": [
"Acute kidney injury (AKI) is common after liver transplantation (OLT) and is associated with high morbidity and mortality. Previous studies have shown that interleukin-18 (IL-18) levels are associated with AKI. The purpose of this study was to determine whether plasma IL-18 levels were early pred... | Plasma IL-18 concentrations taken 1 hour after reperfusion were predictive of AKI. Therefore, changing IL-18 ratio may be an early predictor for AKI after OLT. | yes |
24,767,350 | Do bile CXC motif chemokine 10 levels correlate with anti-donor cytotoxic T cell responses after liver transplantation? | {
"contexts": [
"CXC motif chemokine 10 (CXCL10), known as interferon-γ-induced protein 10, is an inflammatory cytokine secreted by various cells in response to interferon-γ. CXCR3, the receptor of CXCL10, is predominantly expressed on activated T, B, natural killer, and dendritic cells, as well as macrophages. C... | Measurements of bile CXCL10 levels could predict anti-donor cytotoxic T cell responses in liver transplant recipients. | yes |
24,767,353 | Are hypertension and hepatitis C virus infection strong risk factors for developing late renal dysfunction after living donor liver transplantation : significance of renal biopsy? | {
"contexts": [
"Late renal dysfunction (LRD) after liver transplantation develops due to several factors such as viral hepatitis, calcineurin inhibitor, diabetes mellitus, and hypertension. The aim of our study was to clarify the risk factors for LRD after living donor liver plantation (LDLT) by using simple cri... | Although HCV and hypertension were determined to be independent risk factors for LRD after LDLT, a renal biopsy should be performed when clinical symptoms develop regardless of creatinine levels to provide appropriate treatment. | yes |
24,776,707 | Are antibodies to the amino-terminal domain of desmoglein 1 retained during transition from pemphigus vulgaris to pemphigus foliaceus? | {
"contexts": [
"Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two blistering skin diseases mediated by antibodies to desmoglein 3 (Dsg3) and/or Dsg1. Phenotypic transition from PV to PF is rarely reported.",
"To determine the immune response to extracellular (EC) domains of Dsgs during this transi... | Our findings suggest that amino-terminal pathogenic antibodies to the EC domain of Dsg1 were retained, while considerable epitope changes occurred in response to Dsg3 during the shift from PV to PF, with an absolute or significant decrease in pathogenic antibodies to the EC1 domain of Dsg3. | yes |
24,769,404 | Does a rapid two-step algorithm detect and identifies clinical macrolide and beta-lactam antibiotic resistance in clinical bacterial isolates? | {
"contexts": [
"Aiming to identify macrolide and beta-lactam resistance in clinical bacterial isolates rapidly and accurately, a two-step algorithm was developed based on detection of eight antibiotic resistance genes.",
"Targeting at genes linked to bacterial macrolide (msrA, ermA, ermB, and ermC) and beta-... | Having the advantages of the shorter operating time and comparable high sensitivity and specificity with the traditional phenotypic test, our two-step algorithm provides an efficient tool for rapid determination of macrolide and beta-lactam antibiotic resistances in clinical bacterial isolates. | yes |
24,755,016 | Does cognitive executive performance influence functional outcome in euthymic type I bipolar disorder outpatients? | {
"contexts": [
"There is a debate about the influence of executive functioning impairment in the functionality of Bipolar Disorder Type I, even when euthymic (EutBDI). The aim of this study was to explore this relationship, taking functional outcome from a multidimensional point of view.",
"An extended neuro... | Persistent executive deficits in EutBDI may be related to their frequently reported difficulties in personaland occupational adjustment. | yes |
24,746,638 | Does retrograde coronary vein infusion of cardiac explant-derived c-Kit+ cells improves function in ischemic heart failure? | {
"contexts": [
"Progenitor cells isolated from cardiac explant-derived cells improve cardiac function after myocardial infarction (MI). To fully realize the therapeutic potential of these cells, it is essential to develop a safe and efficient delivery method. Therefore, the objective of this study was to determi... | Our study showed that the RCV infusion approach is an efficient technique for targeted cell delivery to the infarcted myocardium. Cardiac c-Kit(+) cells, delivered using RCV infusion ameliorated progression of heart failure, improved cardiac function and retarded myocardial remodeling in heart failure rats. | yes |
24,751,515 | Is stromal cell-derived factor-1-3 ' A polymorphism associated with decreased risk of myocardial infarction and early endothelial disturbance? | {
"contexts": [
"Genome-wide association studies have identified single-nucleotide polymorphisms at the 10q11 locus as risk factors for myocardial infarction (MI). This locus lies upstream (∼80 kb) of the stromal cell-derived factor-1 (SDF1) gene that codify for a chemokine with protective atherogenetic effects a... | SDF1-3'A polymorphism is associated with a decreased risk of MI and early endothelial dysfunction, strongly confirming the important atherogenic role of SDF1 gene at clinical level. | yes |
24,767,172 | Does stress mediate the relationship between sexual orientation and behavioral risk disparities? | {
"contexts": [
"Growing evidence documents elevated behavioral risk among sexual-minorities, including gay, lesbian, and bisexual individuals; however, tests of biological or psychological indicators of stress as explanations for these disparities have not been conducted.",
"Data were from the 2005-2010 Nati... | Higher prevalence of current smoking and lifetime history of substance use was observed among sexual minorities compared to heterosexuals. Among bisexuals, depressive symptoms accounted for only 0.9-3% of the reduction in the association between sexual orientation and marijuana use and tobacco use, respectively. More c... | yes |
24,745,829 | Is telling adolescents a parent dying? | {
"contexts": [
"When a parent is terminally ill, one of the major challenges facing families is informing children of the parent's condition and prognosis. This study describes four ways in which parents disclose information about a parent's life-threatening illness to their adolescent children.",
"We audio-... | Families inform adolescents about the progression of a parent's terminal illness in characteristic ways that remain fairly consistent throughout the illness, and are aimed at easing the adolescents' burden and distress. The families engaged in the process of disclosure in one of four ways: measured telling, skirted tel... | yes |
24,776,965 | Is ( 13 ) C enrichment of the CO2 in breast milk and in the breath rapidly modified by changes in the ( 13 ) C content of the diet? | {
"contexts": [
"C4 plants (e.g. corn and sugar cane) have greater (13)C enrichment than C3 plants (e.g. wheat and sugar beet).",
"To assess whether (13)C enrichment of CO2 in the breath and breast milk of women on diets based on C3 and C4 foods changes from one diet to the other.",
"Six breast-feeding wo... | Subjects eating a C4 diet have a higher δ(13)CPDBV value in the breath and breast milk fractions, which diminish rapidly on a C3 diet. Further studies focusing on individual nutrients are warranted. | yes |
24,773,571 | Does patient-prosthesis mismatch in patients undergoing bioprosthetic aortic valve implantation increase risk of reoperation for structural valve deterioration? | {
"contexts": [
"Patient-prosthesis mismatch has been identified as a risk factor for mortality after aortic valve replacement and for structural valve deterioration (SVD) in patients receiving a bioprosthetic aortic valve. The aim of the present study was to compare the incidence of aortic valve bioprosthesis re... | Patients suffering from mismatch were twice as likely to undergo reoperation for aortic bioprosthesis replacement for SVD than those without mismatch. | yes |
24,750,193 | Does early aggressive nutrition enhance language development in very low-birthweight infants? | {
"contexts": [
"Inadequate nutrition in very-low-birthweight (VLBW) infants is known to be associated with growth failure and poor neurological outcomes. We aimed to investigate the association of early aggressive protein and energy intakes with weight gain and 18-month neurodevelopmental outcomes in VLBW infant... | This study demonstrates the importance of the protein and energy intakes in VLBW infants in the first week of life not only for growth but also for better language development. | yes |
24,751,733 | Do long-term subjective benefit with a bone conduction implant sound processor in 44 patients with single-sided deafness? | {
"contexts": [
"Studies that investigate the subjective benefit from a bone conduction implant (BCI) sound processor in patients with single-sided sensorineural deafness (SSD) have been limited to examining short- and mid-term benefit. In the current study, we performed a survey among 44 SSD BCI users with a med... | The majority of the patients reported an overall improvement from using their BCI. However, the number of users decreases during a longer follow-up time and patients get less enthusiastic about the device after an extended period of use, especially in noisy situations. However, diminished satisfaction because of time-r... | yes |
24,752,040 | Does suv39h1 protect from myocardial ischemia-reperfusion injury in diabetic rats? | {
"contexts": [
"Patients with diabetes are at increased risk of ischemic events. Suv39h1 is a histone methyltransferase that catalyzes the methylation of histone 3 lysine 9, which is associated with the suppression of inflammatory genes in diabetes. However, the role of Suv39h1 in myocardial ischemia/reperfusion... | Overexpression of Suv39h1 results in the de-activation of proinflammatory pathways and reduced apoptosis and myocardial injury. Therefore, Suv39h1 might represent a novel therapeutic strategy to reduce I/R injury under diabetic condition. | yes |
24,763,757 | Is risk of obstructive sleep apnea with daytime sleepiness associated with liver damage in non-morbidly obese patients with nonalcoholic fatty liver disease? | {
"contexts": [
"A high prevalence of obstructive sleep apnea syndrome (OSAS) has been reported in severely obese patients with nonalcoholic fatty liver disease (NAFLD), but few studies have evaluated OSAS in non-morbidly obese NAFLD patients.",
"To determine the prevalence of risk for OSAS with or without da... | A proportion of NAFLD patients without severe obesity is at risk for OSAS with daytime sleepiness, which is associated with the severity of liver damage independently of body mass and other cofactors. | yes |
24,758,591 | Do δ-Opioid receptors in the accumbens shell mediate the influence of both excitatory and inhibitory predictions on choice? | {
"contexts": [
"Stimuli that predict rewarding events can control choice between future actions, and this control could be mediated by δ-opioid receptors in the nucleus accumbens shell (NAc-S). Stimuli predicting the absence of important events can also guide choice, although it remains unknown whether they do s... | These findings suggest that δ-opioid receptors in the NAc-S were involved in the effects of predictive learning on choice between actions, whether those predictions involve the presence or absence of specific rewarding events. | yes |
24,758,255 | Is clusterin/Apolipoprotein J immunolocalization on carotid artery affected by TNF-alpha , cigarette smoking and anti-platelet treatment? | {
"contexts": [
"Clusterin (CLU) /Apolipoprotein J is a protein biosensor of oxidative stress and inflammation, which is upregulated in many pathological processes including atherosclerosis. Previous studies have shown that in aortic tissue, CLU expression increases with atherosclerotic lesion progression and it ... | Our study suggests that CLU expression on carotid artery is affected by TNF-alpha, cigarette smoking confirming its association with oxidative and cellular stress and anti-platelet medication reflecting the protective effects of such pharmacological treatment on vascular wall. | yes |
24,755,743 | Do differences in nicotine metabolism of two Nicotiana attenuata herbivores render them differentially susceptible to a common native predator? | {
"contexts": [
"Nicotiana attenuata is attacked by larvae of both specialist (Manduca sexta) and generalist (Spodoptera exigua) lepidopteran herbivores in its native habitat. Nicotine is one of N. attenuata's important defenses. M. sexta is highly nicotine tolerant; whether cytochrome P450 (CYP)-mediated oxidati... | Nicotine oxidation reduces S. exigua's headspace-nicotine and renders it more susceptible to predation by spiders than M. sexta, which exhales unmetabolized nicotine. These results are consistent with the hypothesis that generalist herbivores incur costs of detoxification, which include the ecological costs of greater ... | yes |
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