pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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24,761,665 | Do [ Quick identification and discrimination of sun-dried and sulfur-fumigated cimicifugae rhizoma by Fourier transform infrared spectroscopy ]? | {
"contexts": [
"To develop a method for quick identification of sun-dried and sulfur-fumigated Cimicifugae Rhizoma by Fourier transform infrared spectroscopy (FTIR).",
"The alcoholic and aqueous extracts of sun-dried and sulfur-fumigated Cimicifugae Rhizoma were analyzed and compared by FTIR combined with se... | The FTIR method combined with the second derivative IR spectrum can be used to analyze and distinguish sun-dried and sulfur-fumigated Cimicifugae Rhizoma quickly and accurately. The developed method provides an efficient approach for the quality control of Chinese herbal medicines with its simplicity and strong specifi... | yes |
24,764,354 | Do early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair? | {
"contexts": [
"Human de novo single-nucleotide variation (SNV) rate is estimated to range between 0.82-1.70×10(-8) mutations per base per generation. However, contribution of early postzygotic mutations to the overall human de novo SNV rate is unknown.",
"We performed deep whole-genome sequencing (more than... | Early postzygotic mutations constitute a substantial proportion of de novo mutations in humans. Therefore, genome mosaicism resulting from early mitotic events during embryogenesis is common and could substantially contribute to the development of diseases. | yes |
24,768,992 | Is routine pathology evaluation of hydrocele and spermatocele specimens associated with significant costs and no identifiable benefit? | {
"contexts": [
"Hydrocelectomy and spermatocelectomy are routine scrotal surgeries. A significant number of the surgical specimens are sent for pathology analysis. However, to our knowledge no study has been done to examine outcomes and necessity, which results in significant potentially unnecessary costs to the... | No malignancy was detected in 159 hydrocele and spermatocele specimens during the 14 study years, suggesting that the pathology analysis is of little clinical benefit. Forgoing surgical pathology analysis of these specimens would result in significant cost savings to the patient and the health care system. | yes |
24,777,731 | Does opioid use after fracture surgery correlate with pain intensity and satisfaction with pain relief? | {
"contexts": [
"In 2012, Medicare began to tie reimbursements to inpatient complications, unplanned readmissions, and patient satisfaction, including satisfaction with pain management.",
"We aimed to identify factors that correlate with (1) pain intensity during a 24-hour period after surgery; (2) less than ... | After operative fracture treatment, patients who take more opioids report greater pain intensity and less satisfaction with pain relief. Greater self-efficacy was the best determinant of satisfaction with pain relief. Evidence-based interventions to increase self-efficacy merit additional study for the management of po... | yes |
24,746,569 | Are blood biomarkers helpful in the prediction of response to chemoradiation in rectal cancer : a prospective , hypothesis driven study on patients with locally advanced rectal cancer? | {
"contexts": [
"Chemoradiation (CRT) has been shown to lead to downsizing of an important portion of rectal cancers. In order to tailor treatment at an earlier stage during treatment, predictive models are being developed. Adding blood biomarkers may be attractive for prediction, as they can be collected very ea... | CEA and IL-8 were identified as predictive biomarkers for tumor response and PCR after CRT in rectal cancer. Incorporation of these blood biomarkers leads to an additional accuracy of earlier developed prediction models using clinical variables and PET-information. The new model could help to an early adaptation of tre... | yes |
24,746,566 | Are genetic variants in inducible nitric oxide synthase gene associated with the risk of radiation-induced lung injury in lung cancer patients receiving definitive thoracic radiation? | {
"contexts": [
"Nitric oxide (NO), mainly synthesized by inducible nitric oxide synthase (NOS2) in pathological conditions, plays an important role in cytotoxicity, inflammation and fibrosis. Elevations in exhaled NO after thoracic radiation have been reported to predict radiation-induced lung injury (RILI). Thi... | Our results demonstrate that genetic variants of NOS2 may serve as a reliable predictor of RILI in lung cancer patients treated with thoracic radiation. | yes |
24,773,941 | Is the positive influence of methotrexate on the mortality of patients with rheumatoid arthritis partly independent of its effect on disease activity : results of a re-evaluation 18 years after baseline? | {
"contexts": [
"Methotrexate (MTX) is the anchor drug in the treatment of patients with rheumatoid arthritis (RA). MTX shows effects on disease activity and mortality. However, it is unclear whether the effect of MTX on mortality depends on its effect on disease activity.",
"In a post-hoc analysis we analyse... | In this cohort, the mortality lowering effect of continued MTX use was partly independent of its effect on disease activity. This finding may affect treatment decisions concerning RA patients with insufficient response to MTX. | yes |
24,759,959 | Does methylglyoxal impair endothelial insulin sensitivity both in vitro and in vivo? | {
"contexts": [
"Insulin exerts a direct action on vascular cells, thereby affecting the outcome and progression of diabetic vascular complications. However, the mechanism through which insulin signalling is impaired in the endothelium of diabetic individuals remains unclear. In this work, we have evaluated the r... | MGO impairs the action of insulin on the endothelium both in vitro and in vivo, at least in part through an ERK1/2-mediated mechanism. These findings may be instrumental in developing novel strategies for preserving endothelial function in diabetes. | yes |
24,761,813 | Is transsulfuration an active pathway for cysteine biosynthesis in Trypanosoma rangeli? | {
"contexts": [
"Cysteine, a sulfur-containing amino acid, plays an important role in a variety of cellular functions such as protein biosynthesis, methylation, and polyamine and glutathione syntheses. In trypanosomatids, glutathione is conjugated with spermidine to form the specific antioxidant thiol trypanothio... | These findings demonstrate that the RTS pathway is active in T. rangeli, suggesting that this may be the only pathway for cysteine biosynthesis in this parasite. In this sense, the RTS pathway appears to have an important functional role during the insect stage of the life cycle of this protozoan parasite. | yes |
24,777,158 | Does dehydration affect spinal cord cross-sectional area measurement on MRI in healthy subjects? | {
"contexts": [
"This was a prospective cohort observational study.",
"To determine the effect of dehydration and rehydration on spinal cord cross-sectional area (CSA) measurement on magnetic resonance imaging (MRI).",
"MRI Research Centre, University of British Columbia, Canada.",
"Ten healthy subjec... | Dehydration can confound CSA measurements on MRI. The magnitude of the effect is significant relative to short-term pathological changes that have been observed in diseases such as multiple sclerosis. | yes |
24,756,738 | Is mean platelet volume associated with glycaemic control and retinopathy in patients with type 2 diabetes mellitus? | {
"contexts": [
"To investigate the relationship between mean platelet volume (MPV) and glycometabolic indices, to compare MPV according to HbA1c levels, and to analyse the difference in MPV between patients with and without microvascular complications.",
"This retrospective study was conducted on 60 Type 2 d... | This study has shown that an increased MPV is closely associated with poor glycaemic control, which may be a risk factor for diabetic retinopathy. Nonetheless, further prospective studies are needed to assess the relationship between MPV, glycaemic indices and microvascular complications. | yes |
24,763,405 | Is younger age associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents? | {
"contexts": [
"The use of digital reactive hyperemia as a measure of endothelial function among children and adolescents is becoming increasingly common. However, unexpected observations of low reactive hyperemic index values in younger children in our laboratory led us to conduct a study evaluating the influen... | Younger age is associated with lower RHI but not lower FMD among children and adolescents. These findings call into question the validity and usefulness of digital reactive hyperemia as a method to quantify endothelial function among younger children. | yes |
24,763,407 | Is low serum bilirubin concentration a predictor of chronic kidney disease? | {
"contexts": [
"Chronic kidney disease (CKD) is a worldwide public health problem. It is very important to identify the factors that affect CKD. Previous studies have reported that serum bilirubin concentration was positively correlated with renal function in a cross-sectional study. The aim of this study was to... | Our study demonstrated that serum total bilirubin concentration could be a novel risk factor for the progression of CKD, defined as eGFR <60 ml/min/1.73 m(2), in the general population. | yes |
24,767,324 | Is repeated introperative cholangiography helpful for donor safety in the procurement of right liver graft with supraportal right bile duct variants in living-donor liver transplantation? | {
"contexts": [
"Despite recent advances in preoperative diagnostic imaging and operative techniques, biliary variation of the donor still remains a challenge in the procurement of graft. The supraportal right bile duct (BD) variant including presentation as trifurcation is a potential trap for injuring the remna... | Repeated IOC is suggested as a routine for variants of supraportal right bile ducts especially trifurcation pattern in graft procurement to avoid the injury of donor remnant bile ducts. | yes |
24,776,717 | Is growth in preterm infants until 36 weeks ' postmenstrual age close to target recommendations? | {
"contexts": [
"To establish the determinants of weight, length and head circumference changes during their initial hospitalization in very-low-birth-weight preterm infants.",
"A prospective cohort study was performed. Weight z-score and percentage of target dietary intakes (TDIs) were prospectively determin... | Despite achieving a protein and energy intake close to the described target intake, the rate of growth in our infants was lower than indicated by the intrauterine growth curve. Lower gestational age, lower birth weight and severe illness had a negative effect on growth. | yes |
24,748,281 | Is transient intrauterine fluid accumulation not due to hydrosalpinx or any identifiable pelvic pathology detrimental to IVF outcome? | {
"contexts": [
"This study is to assess whether transient intrauterine fluid accumulation (IUFA) first noted during controlled ovarian hyperstimulation that does not persist on the day of embryo transfer not due to any identifiable pelvic pathology has any detrimental effect on in vitro fertilization (IVF) outco... | Transient IUFA not due to hydrosalpinx or any identifiable pelvic pathology has no detrimental effect on IVF pregnancy rates. Hence, cycle cancellation should be avoided in such cycles. | no |
24,774,218 | Is down regulation of miR-143 related with tumor size , lymph node metastasis and HPV16 infection in cervical squamous cancer? | {
"contexts": [
"This study is to investigate the role of miR-143 expression in cervical squamous cell carcinoma (SCC).",
"The expression level of miR-143 was examined by quantitative real-time PCR. Human papillomavirus (HPV) genotype was detected by HPV genotype detection kit. The expression level of bcl-2 w... | Down-regulated miR-143 is related with tumor size, lymph node metastasis and HPV16 infection in cervical SCC, but miR-143 does not participate in the Taxol sensitivity response. | yes |
24,765,229 | Does video education provide effective wound care instruction pre- or post-mohs micrographic surgery? | {
"contexts": [
"The objective of this study was to determine if delivery of wound care instruction pre-Mohs micrographic surgery versus the typical, post-Mohs surgery would allow for greater patient retention.",
"A non-blinded, randomized, controlled trial receiving institutional review board exemption from ... | Video education prior to or post-Mohs surgery serves as an effective mechanism for patient education and improvement of time management in clinical practice. | yes |
24,754,983 | Do [ Effects of continuous positive airway pressure treatment of inflammatory factors in patients with overlap syndrome ]? | {
"contexts": [
"To explore the effects of continuous positive airway pressure (CPAP) treatment on the serum levels of associated inflammatory factors in patients with overlap syndrome (OS).",
"Seventy-four patients with obstructive sleep apnea syndrome (OSAS) or chronic obstructive pulmonary disease (COPD) o... | CPAP treatment significantly reduces the serum levels of CRP and TNF-α so as to improve inflammation responses in OS and OSAS patients. | yes |
24,755,887 | Is tumour-initiating capacity independent of epithelial-mesenchymal transition status in breast cancer cell lines? | {
"contexts": [
"Epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) are considered to be crucial for cancer biology. The purpose of this study was to determine whether EMT directly led to the acquisition of tumour-initiating capacity in breast cancer cell lines.",
"Epithelial-mesenchymal tra... | Epithelial-mesenchymal transition does not alter tumour-initiating capacity of breast cancer cells but some other biological characteristics. Therefore, EMT and tumour-initiating capacity may not be directly linked in breast cancer cell lines. | yes |
24,758,388 | Does rutin protect against cognitive deficits and brain damage in rats with chronic cerebral hypoperfusion? | {
"contexts": [
"Chronic cerebral hypoperfusion is a critical causative factor for the development of cognitive decline and dementia in the elderly, which involves many pathophysiological processes. Consequently, inhibition of several pathophysiological pathways is an attractive therapeutic strategy for this diso... | Our results provide new insights into the pharmacological actions of rutin and suggest that rutin has multi-targeted therapeutical potential on cognitive deficits associated with conditions with chronic cerebral hypoperfusion such as vascular dementia and Alzheimer's disease. | yes |
24,758,347 | Are starch biosynthetic genes and enzymes expressed and active in the absence of starch accumulation in sugar beet tap-root? | {
"contexts": [
"Starch is the predominant storage compound in underground plant tissues like roots and tubers. An exception is sugar beet tap-root (Beta vulgaris ssp altissima) which exclusively stores sucrose. The underlying mechanism behind this divergent storage accumulation in sugar beet is currently not ful... | Considering underground storage organs, sugar beet tap-root upholds a unique property in exclusively storing sucrose. Lack of starch also in the ancestor sea beet indicates an evolved trait of biological importance.Our findings in this study show that gene expression and enzymatic activity of main starch biosynthetic f... | yes |
24,765,534 | Is conventional cytology beneficial for predicting peritoneal recurrence after curative surgery for gastric cancer : results of a prospective clinical study? | {
"contexts": [
"The role of peritoneal washing cytology in determining further treatment strategies after surgery for gastric cancer remains unclear. One reason for this is the fact that optimal procedures to increase the accuracy of predicting peritoneal metastasis have not been established. The aim of this stu... | Peritoneal washing cytology using samples harvested from two different sites in the abdominal cavity was not able to predict peritoneal recurrence or survival in gastric cancer patients. Further studies will be required to determine whether peritoneal washing cytology during gastric cancer surgery is a meaningful proce... | no |
24,752,976 | Does toll-like receptor 2/4 heterodimer mediate inflammatory injury in intracerebral hemorrhage? | {
"contexts": [
"Inflammatory injury plays a critical role in intracerebral hemorrhage (ICH)-induced secondary brain injury. However, the upstream events that initiate inflammatory responses following ICH remain elusive. Our previous studies suggested that Toll-like receptor 4 (TLR4) may be the upstream signal th... | Our results suggest that a novel TLR2/TLR4 heterodimer induced by Hb initiates inflammatory injury in ICH. Interfering with the assembly of the TLR2/TLR4 heterodimer may be a novel target for developing effective treatment of ICH. | yes |
24,774,171 | Are bacteriocin-encoding genes and ExPEC virulence determinants associated in human fecal Escherichia coli strains? | {
"contexts": [
"A set of 1181 E. coli strains of human fecal origin isolated in the South Moravia region of the Czech Republic was collected during the years 2007-2010. Altogether, 17 virulence determinants and 31 bacteriocin-encoding genes were tested in each of them.",
"The occurrence of bacteriocin-encodi... | The occurrence of bacteriocin-encoding genes and ExPEC virulence determinants correlate positively in E. coli strains of human fecal origin. Bacteriocin synthesis appears to modulate the ability of E. coli strains to reside in the human intestine and/or the virulence of the corresponding strains. | yes |
24,755,398 | Do momentary negative moods and being with friends precede cigarette use among Korean American emerging adults? | {
"contexts": [
"The objective of this study was to determine contextual antecedents to smoking among Korean American emerging adult (KAEA) smokers using ecological momentary assessment. Based on extant theory and data documenting the importance of negative affect (NA) and social context, we examined the extent t... | Unlike more established smokers, these younger smokers may be strongly influenced by peer contexts as well as unpleasant affect. The interaction between social contexts and NA highlights a potential window for intervention for the population of KAEA smokers. | yes |
24,769,814 | Is red cell distribution width increased in patients with ascending aortic dilatation? | {
"contexts": [
"The prognostic importance of red cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) in cardiovascular diseases has been shown. Ascending aortic dilatation (AAD) is a common cardiovascular disease and is associated with aortic wall inflammation and cystic degeneration. In this stu... | In patients with AAD, RDW and hs-CRP levels are increased, which may indicate the role of inflammation in the pathogenesis of AAD. | yes |
24,763,172 | Does weak evidence support the short-term benefits of orthopaedic treatment for Class III malocclusion in children? | {
"contexts": [
"Data sources The Cochrane Oral Health Group's Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), Medline and Embase.",
"Randomised controlled trials (RCTs) of orthodontic treatment to correct prominent lower front teeth were included.",
"Study screening, risk o... | There is some evidence that the use of a facemask to correct prominent lower front teeth in children is effective when compared to no treatment on a short-term basis. However, in view of the general poor quality of the included studies, these results should be viewed with caution. Further randomised controlled trials w... | yes |
24,763,175 | Do radiotherapy associated with higher rates of dental implant loss? | {
"contexts": [
"Cochrane Oral Health Group's Trials Register, CENTRAL, Medline via PubMed and EMBASE; no restrictions on language, published before February 1st 2013.",
"Observational studies reporting outcomes from irradiated and non-irradiated patients were eligible for inclusion as were randomised control... | Irradiation of the head was linked to increased failure rate of implants compared to failure rates in patients who had not undergone radiotherapy. The failure rate was higher in the maxilla and HBO therapy did not improve implant survival. | yes |
24,776,940 | Do effectiveness of disinfection therapies and promotion of osteoblast growth on osseotite and nanotite implant surfaces? | {
"contexts": [
"To evaluate the effectiveness of 4 procedures to disinfect implant surfaces intentionally inoculated with bacteria and afterward to evaluate osteoblast viability to the disinfected implant surfaces.",
"Eighty-eight commercially pure Osseotite and Nanotite titanium implant discs were inoculate... | The Nanotite implant discs were the most difficult to disinfect, likely because of their chemical and physical properties. Citric acid and tetracycline were most effective for disinfecting the Osseotite implant discs, and further clinical research is needed to verify these effects in vivo. The Nd:YAG laser was the weak... | yes |
24,761,684 | Is modified sequential Helicobacter pylori eradication therapy using high dose omeprazole and amoxicillin in the initial phase in the extensive metaboliser Turkish patients for CYP2C19 polymorphism ineffective? | {
"contexts": [
"To investigate whether the sequential therapy composed of high dose omeprazole and high dose amoxicillin in the first step was effective in eradication of H. pylori and whether there was a relation between effectiveness of the therapy and CYP2C19 gene polymorphism.",
"134 dyspeptic patients w... | This modified high-dose sequential therapy was ineffective in a Turkish sample, nearly all of whom had EM in terms of CYP2C19 gene status. | yes |
24,772,074 | Do residual neural processing of musical sound features in adult cochlear implant users? | {
"contexts": [
"Auditory processing in general and music perception in particular are hampered in adult cochlear implant (CI) users. To examine the residual music perception skills and their underlying neural correlates in CI users implanted in adolescence or adulthood, we conducted an electrophysiological and b... | -Automatic brain responses to musical feature changes reflect the limitations of central auditory processing in adult Cochlear Implant users.-The brains of adult CI users automatically process sound features changes even when inserted in a musical context.-CI users show disrupted automatic discriminatory abilities for ... | yes |
24,771,567 | Does ultraviolet B light attenuate the systemic immune response in central nervous system autoimmunity? | {
"contexts": [
"Environmental conditions (eg, latitude) play a critical role in the susceptibility and severity of many autoimmune disorders, including multiple sclerosis (MS). Here, we investigated the mechanisms underlying the beneficial effects of immune regulatory processes induced in the skin by moderate ul... | Local UVB radiation of the skin influences systemic immune reactions and attenuates systemic autoimmunity via the induction of skin-derived tolerogenic DCs and Tregs. Our data could have implications for the understanding or therapeutic modulation of environmental factors that influence immune tolerance. | yes |
24,768,608 | Is the mechanical fibrillation pattern of the atrial myocardium associated with acute and long-term success of electrical cardioversion in patients with persistent atrial fibrillation? | {
"contexts": [
"Electrophysiological studies demonstrate that a short atrial fibrillation cycle length (AFCL) is related with poor outcome of electrical cardioversion (ECV) of atrial fibrillation (AF). We found previously that the mechanical AFCL (AFCL-tvi) and atrial fibrillatory velocity (AFV-tvi) may be deter... | Higher atrial fibrillatory wall velocities and longer AFCLs determined by echocardiography are associated with acute and long-term success of ECV. | yes |
24,747,463 | Do retrospective analysis of facial dog bite injuries at a Level I trauma center in the Denver metro area? | {
"contexts": [
"Facial dog bite injuries pose a significant public health problem.",
"Seventy-five consecutive patients (45 males, 30 females) treated solely by plastic surgery service for facial dog bite injuries at a Level I trauma center in the Denver Metro area between 2006 and 2012 were retrospectively ... | Availability of the plastic surgery service at a Level I trauma center is vital for the optimal treatment of facial dog bite injuries. Direct repair and reconstruction of facial dog bite injuries at the earliest opportunity resulted in good outcomes as evidenced by the satisfaction survey data and low complication rate... | yes |
24,747,464 | Does levothyroxine therapy before brain death declaration increase the number of solid organ donations? | {
"contexts": [
"Protocols call for the start of hormonal therapy with levothyroxine after the declaration of brain death. As the hormonal perturbations occur during the process of brain death, the role of the early initiation of levothyroxine therapy (LT) to salvage organs is not well defined. The aim of this st... | The early use of LT and aggressive blood product resuscitation was associated with a significantly higher number of solid organs donated per donor. Earlier use of LT before the declaration of brain death may be considered in potential organ donors. | yes |
24,747,465 | Is preinjury ambulatory status associated with 1-year mortality following lateral compression Type I fractures in the geriatric population older than 80 years? | {
"contexts": [
"Lateral compression pelvic Type I fractures in the elderly population are most often low-energy osteoporosis related fractures. Previous literature comparing pelvic fractures in young versus elderly patients called into question the general consideration of these injuries as benign injuries with ... | This is the first study to demonstrate a difference in 1-year mortality between patients who were community ambulators versus those who were household ambulators or nonfunctional ambulators before injury. With our aging population, these findings have important implications. Maintenance of general conditioning and earl... | yes |
24,755,322 | Is tumor necrosis factor inhibitor therapy but not standard therapy associated with resolution of erosion in the sacroiliac joints of patients with axial spondyloarthritis? | {
"contexts": [
"Radiography is an unreliable and insensitive tool for the assessment of structural lesions in the sacroiliac joints (SIJ). Magnetic resonance imaging (MRI) detects a wider spectrum of structural lesions but has undergone minimal validation in prospective studies. The Spondyloarthritis Research Co... | The SPARCC SSS method for assessment of structural lesions has discriminative capacity in demonstrating significantly greater reduction in erosion and new fat metaplasia in patients receiving anti-TNFα therapy. | yes |
24,767,643 | Is serum cytokeratin-19 fragment ( Cyfra 21-1 ) a prognostic indicator for epithelial ovarian cancer? | {
"contexts": [
"Cytokeratin 19 is significant for indicating cancer cells, and Cyfra 21-1 is a fragment of cytokeratin 19. This retrospective study was designed to define the prognostic value of serum Cyfra 21-1 in epithelial ovarian cancers (EOC).",
"Serum Cyfra 21-1 concentration was obtained from 42 patie... | The pretreatment level of serum Cyfra 21-1 had remarkable prognostic significance for EOC, indicating poor survival when it was elevated above 3.0 ng/mL. | yes |
24,769,340 | Is serum acid sphingomyelinase upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease? | {
"contexts": [
"Sphingolipids constitute bioactive molecules with functional implications in homeostasis and pathogenesis of various diseases. However, the role of sphingolipids as possible disease biomarkers in chronic liver disease remains largely unexplored. In the present study we used mass spectrometry and ... | Chronic hepatitis C virus infection and non-alcoholic fatty liver disease induce a significant upregulation of serum acid sphingomyelinase which appears as a novel biomarker in chronic hepatopathies. Further studies are required to elucidate the potential of the sphingolipid signaling pathway as putative therapeutic ta... | yes |
24,773,414 | Do eye movements reveal impaired inhibitory control in adult male fragile X premutation carriers asymptomatic for FXTAS? | {
"contexts": [
"Fragile X premutation carriers (fXPCs) have an expansion of 55-200 CGG repeats in the FMR1 gene. Male fXPCs are at risk for developing a neurodegenerative motor disorder (FXTAS) often accompanied by inhibitory control impairments, even in fXPCs without motor symptoms. Inhibitory control impairmen... | Antisaccades require inhibitory control to inhibit reflexive eye movements. We found that eye movements are sensitive to impaired inhibitory control in fXPCs asymptomatic for FXTAS. Thus, eye movements may be useful in assessing FXTAS risk or disease progression. | yes |
24,777,728 | Does carpal tunnel syndrome impair thumb opposition and circumduction motion? | {
"contexts": [
"Carpal tunnel syndrome is associated with sensory and motor impairments resulting from the compressed and malfunctioning median nerve. The thumb is critical to hand function, yet the pathokinematics of the thumb associated with carpal tunnel syndrome are not well understood.",
"The purpose of... | Carpal tunnel syndrome disrupts kinematics of the thumb during opposition and circumduction despite normal pinch strength. | yes |
24,763,612 | Does genome-wide study of hypomethylated and induced genes in patients with liver cancer unravel novel anticancer targets? | {
"contexts": [
"We utilized whole-genome mapping of promoters that are activated by DNA hypomethylation in hepatocellular carcinoma (HCC) clinical samples to shortlist novel targets for anticancer therapeutics. We provide a proof of principle of this approach by testing six genes short-listed in our screen for t... | Our results prove that genes that are hypomethylated and induced in tumors are candidate targets for anticancer therapeutics in multiple cancer cell types. Because these genes are particularly activated in cancer, they constitute a group of targets for specific pharmacologic inhibitors of cancer and cancer metastasis. ... | yes |
24,764,342 | Does low-intensity pulsed ultrasound induce osteogenic differentiation of human periodontal ligament cells through activation of bone morphogenetic protein-smad signaling? | {
"contexts": [
"Low-intensity pulsed ultrasound (US) can accelerate fracture healing and osteogenic differentiation. The aim of this study was to investigate the osteogenic effect of low-intensity pulsed US on human periodontal ligament cells and to determine whether bone morphogenetic protein (BMP)-Smad signali... | Low-intensity pulsed US effectively induced osteogenic differentiation of human periodontal ligament cells, and the BMP-Smad signaling pathway was involved in the mechanism. | yes |
24,777,720 | Does paley 's multiplier method accurately predict adult height in children with bone sarcoma? | {
"contexts": [
"The majority of patients with osteosarcoma and Ewing's sarcoma are diagnosed before skeletal maturity. Paley's multiplier is used for height prediction in healthy children, and has been suggested as a method to make growth predictions for children with osteosarcoma and Ewing's sarcoma when consid... | Owing to its lack of reliability in this patient group, methods other than Paley's should be evaluated to predict adult height. Although limited by a small number of patients, our study results indicate a decreased adult height in patients with bone sarcoma after chemotherapy. | no |
24,751,831 | Does fasting protect liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice? | {
"contexts": [
"Fasting and calorie restriction are associated with a prolonged life span and an increased resistance to stress. The protective effects of fasting have been exploited for the mitigation of ischemic organ injury, yet the underlying mechanisms remain incompletely understood. Here, we investigated w... | Fasting for one day protects from hepatic IR injury via Sirt1-dependent downregulation of circulating HMGB1. The reduction in serum HMGB1 appears to be mediated by its engagement in the autophagic response. These findings integrate Sirt1, HMGB1, and autophagy into a common framework that underlies the anti-inflammatory... | yes |
24,751,833 | Does pPAR-alpha dependent regulation of vanin-1 mediate hepatic lipid metabolism? | {
"contexts": [
"Peroxisome proliferator-activated receptor alpha (PPARα) is a key regulator of hepatic fat oxidation that serves as an energy source during starvation. Vanin-1 has been described as a putative PPARα target gene in liver, but its function in hepatic lipid metabolism is unknown.",
"We investiga... | We show that hepatic vanin-1 is under extremely sensitive regulation by PPARα and that plasma vanin activity could serve as a readout of changes in PPARα activity in human subjects. In addition, our data propose a role for vanin-1 in regulation of hepatic TG levels during fasting. | yes |
24,750,356 | Does coffee consumption and the risk of latent autoimmune diabetes in adults -- result from a Swedish case-control study? | {
"contexts": [
"Coffee consumption is associated with a reduced risk of Type 2 diabetes. Our aim was to investigate if coffee intake may also reduce the risk of latent autoimmune diabetes in adults, an autoimmune form of diabetes with features of Type 2 diabetes.",
"We used data from a population-based case-... | Our findings confirm that coffee consumption is associated with a reduced risk of Type 2 diabetes. Interestingly, the findings suggest that coffee may be associated with development of autoimmunity and possibly an increased risk of more Type 1-like latent autoimmune diabetes in adults. | yes |
24,747,114 | Does downregulation of the glucocorticoid-induced leucine zipper ( GILZ ) promote vascular inflammation? | {
"contexts": [
"Glucocorticoid-induced leucine zipper (GILZ) represents an anti-inflammatory mediator, whose downregulation has been described in various inflammatory processes. Aim of our study was to decipher the regulation of GILZ in vascular inflammation.",
"Degenerated aortocoronary saphenous vein bypas... | Our data show a diminished expression of the anti-inflammatory mediator GILZ in the inflamed vasculature and indicate that GILZ downregulation requires the mRNA binding protein ZFP36. We suggest that reduced GILZ levels play a role in cardiovascular disease. | yes |
24,770,609 | Is playground Safety Associated With Playground , Park , and Neighborhood Characteristics? | {
"contexts": [
"More than 200,000 children each year are treated at emergency departments for injuries occurring on playgrounds. Empirically derived data are needed to elucidate factors associated with playground safety and reduce injury rates.",
"Determine if neighborhood, park and playground characteristic... | Park safety levels need to be improved to reduce the risk of physical injuries. Future studies examining cause-effect associations between environmental features and playground safety are warranted. | yes |
24,746,950 | Is aortic valve calcification mediated by a differential response of aortic valve interstitial cells to inflammation? | {
"contexts": [
"Although calcific aortic stenosis is common, calcification of the other three heart valves is not. The aortic valve interstitial cell (VIC) has been implicated in the pathogenesis of aortic stenosis. Proinflammatory stimulation of aortic VICs induces an osteogenic and inflammatory phenotypic chan... | Proinflammatory stimulation induces an osteogenic phenotype in aortic VICs but not mitral, pulmonic, or tricuspid VICs. We conclude that this differential osteogenic response of aortic VICs contributes to the pathogenesis of calcific aortic stenosis. | yes |
24,756,010 | Is inflammation the cause of an elevated serum ferritin in non-alcoholic fatty liver disease? | {
"contexts": [
"In non-alcoholic fatty liver disease (NALFD), it has often been assumed that an elevation in serum ferritin is likely related to inflammation rather than iron overload.",
"Patients referred with NAFLD were entered into a clinical study of phlebotomy therapy. A liver biopsy with liver iron con... | Serum ferritin is related to liver iron storage in NAFLD and decreasing body iron stores by phlebotomy is reflected by an appropriate decrease in serum ferritin. Inflammation is not the cause of the elevated serum ferritin in fatty liver disease. | no |
24,751,545 | Does pain self-efficacy mediate the relationship between depressive symptoms and pain severity? | {
"contexts": [
"We examined the relationships between depressive symptoms, pain severity, and pain self-efficacy (PSE) in patients with chronic low back pain (CLBP). We hypothesized that change in depressive symptoms would significantly influence change in pain severity, and that PSE indirectly affects this rela... | These findings suggest that pain management and rehabilitation programs for CLBP should specifically target PSE as a key aspect of treatment. | yes |
24,754,849 | Is polymorphism in the epidermal growth factor gene associated with pre-eclampsia and low birthweight? | {
"contexts": [
"We have previously reported that polymorphism in the epidermal growth factor (EGF) gene is associated with pre-eclampsia and birthweight based on case-control association studies involving two single nucleotide polymorphisms (SNP). We extended that work to investigate other SNP in the EGF gene fo... | In this study we found further evidence for the association of polymorphism in the EGF gene with pre-eclampsia and the weight of babies at birth and identified rs3756261A>G as the SNP that makes the most significant contribution to this association. Bioinformatic analysis showed that this effect may be mediated by caud... | yes |
24,774,962 | Do insulin resistant rats display enhanced rewarding effects of nicotine? | {
"contexts": [
"Tobacco use among persons with Type II diabetes exponentially increases negative health consequences and mortality rates. It is especially troubling that diabetic persons who smoke have a greater difficulty with tobacco cessation as compared to non-diabetic smokers. Diabetes is a metabolic syndro... | These present study suggests that insulin resistant rats undergo unique neurobiological changes related to a disruption in insulin signaling that promotes the rewarding effects of nicotine. | yes |
24,749,130 | Is immature reticulocyte fraction an early predictor of bone marrow recovery post chemotherapy in patients with acute leukemia? | {
"contexts": [
"To establish the benefits of immature reticulocyte fraction (IRF) measurement using an automated hematology cells analyzer over absolute neutrophil count (ANC) in predicting bone marrow recovery post induction chemotherapy.",
"A prospective observational study was carried out in the Departmen... | This study proved that IRF was more useful in predicting bone marrow recovery in a patient with acute leukemia post induction chemotherapy compared with ANC. The IRF is not affected by infection, is easily measured, and inexpensive; thus, it is a reliable parameter to evaluate bone marrow reconstitution. | yes |
24,773,608 | Are nadir PSA level and time to nadir PSA prognostic factors in patients with metastatic prostate cancer? | {
"contexts": [
"Primary androgen deprivation therapy (PADT) is the most effective systemic therapy for patients with metastatic prostate cancer. Nevertheless, once PSA progression develops, the prognosis is serious and mortal. We sought to identify factors that predicted the prognosis in a series of patients wit... | Nadir PSA and time from PADT to nadir were factors that affect both CRPC and overall survival in a cohort of patients with metastatic prostate cancer. Lower nadir PSA level and longer time from PADT to nadir were good for survival and progression. | yes |
24,746,282 | Do skin stretching for primary closure of acute burn wounds? | {
"contexts": [
"In burn care, a well-acknowledged problem is the suboptimal scar outcome from skin grafted burn wounds. With the aim of improving this, we focused on a new technique: excision of the burn wound followed by primary closure, thereby using a skin-stretching device to stretch the adjacent healthy ski... | Skin Stretch for primary closure of acute burn wounds is a suitable technique and can be considered for specific circumscript full-thickness burn wounds. However, future research should be performed to provide additional scientific evidence. | yes |
24,771,644 | Is canonical androstenedione reduction the predominant source of signaling androgens in hormone-refractory prostate cancer? | {
"contexts": [
"It has been recognized for almost a decade that concentrations of signaling androgens sufficient to activate the androgen receptor are present in castration-resistant prostate cancer tissue. The source of these androgens is highly controversial, with three competing models proposed. We, therefore... | Reduction of androstenedione to testosterone by the canonical HSD17B AKR1C3 is the predominant source of signaling androgens in HRPC. | yes |
24,771,647 | Is hsa-miR-31-3p expression linked to progression-free survival in patients with KRAS wild-type metastatic colorectal cancer treated with anti-EGFR therapy? | {
"contexts": [
"To identify microRNAs (miRNA) that predict response to anti-EGFR antibodies in patients with wild-type KRAS metastatic colorectal cancer (mCRC).",
"miRNA profiling was performed in a training set of 87 patients with mCRC refractory to chemotherapy treated with anti-EGFR antibodies. This inclu... | Hsa-miR-31-3p seems to be a new mCRC biomarker whose expression level allows for the identification of patients with wild-type KRAS mCRC who are more likely to respond to anti-EGFR therapy. | yes |
24,771,642 | Does rNAi screen identify a synthetic lethal interaction between PIM1 overexpression and PLK1 inhibition? | {
"contexts": [
"To identify genes whose depletion is detrimental to Pim1-overexpressing prostate cancer cells and to validate this finding in vitro and in vivo.",
"RNAi screening was used to identify genes whose depletion is detrimental to Pim1-overexpressing cells. Our finding was validated using shRNA or P... | Our findings demonstrate that PIM1-overexpressing cancer cells are particularly sensitive to PLK1 inhibition, suggesting that PIM1 might be used as a marker for identifying patients who will benefit from PLK1 inhibitor treatment. | yes |
24,777,737 | Do ramp-incremented and RPE-clamped test protocols elicit similar VO2max values in trained cyclists? | {
"contexts": [
"The present study compared the efficacy of ramp incremented and ratings of perceived exertion (RPE)-clamped test protocols for eliciting maximal oxygen uptake (VO2max).",
"Sixteen trained cyclists (age 34 ± 7 years) performed a ramp-incremented protocol and an RPE-clamped protocol 1 week apar... | The RPE-clamped test protocol was as effective as the ramp-incremented protocol for eliciting VO2max and could be considered as a valid alternative protocol, particularly where a fixed test duration is desirable. | yes |
24,748,587 | Does caregiver Quality of Life be Related to Severity of Otitis Media in Children? | {
"contexts": [
"Otitis media (OM) in children is the most frequent reason for physician visits in developed countries and burdens caregivers, society, and the child. Our objective was to describe the impact of OM severity on parent/caregiver quality of life (QoL).",
"Multi-institutional prospective cross-sec... | Worse PedsQL Family Impact and PROMIS scores were highly correlated with elevated OM-6 scores, suggesting that severity of childhood OM significantly affects parent/caregiver QoL. Understanding the impact of a child's illness on parent/caregiver QoL can help physicians counsel patients and families and provide better f... | yes |
24,751,531 | Are perioperative complications after hemiarthroplasty and total shoulder arthroplasty equivalent? | {
"contexts": [
"Total shoulder arthroplasty (TSA) results in superior clinical outcomes to hemiarthroplasty (HA); however, TSA is a more technical and invasive procedure. This study retrospectively compares perioperative complications after HA and TSA using the National Surgical Quality Improvement Program (NSQI... | Multivariate analysis of patients undergoing TSA or HA in the NSQIP database suggests that patient factors-not the procedure being performed-are significant predictors of major complications. Controlling for patient comorbidities, we found no increased risk of perioperative major complications in patients undergoing TS... | yes |
24,762,943 | Are action potentials in retinal ganglion cells initiated at the site of maximal curvature of the extracellular potential? | {
"contexts": [
"The initiation of an action potential by extracellular stimulation occurs after local depolarization of the neuronal membrane above threshold. Although the technique shows remarkable clinical success, the site of action and the relevant stimulation parameters are not completely understood.",
... | We present a framework how to estimate the site of action potential initiation and the stimulus required to cross threshold in neurons tightly interfaced to capacitive stimulation electrodes. Our results underscore the necessity of rigorous electrical characterization of the stimulation electrodes and of the interfaced... | yes |
24,766,747 | Are vitamin D deficiency in community-acquired pneumonia : low levels of 1,25 ( OH ) 2 D associated with disease severity? | {
"contexts": [
"We aimed to explore the association between vitamin D levels and the severity, mortality and microbiological etiology of community-acquired pneumonia.",
"Vitamin D levels (both, the reservoir form 25-OH and the activated form 1,25-OH2) of 300 randomly selected patients with community-acquired... | For 1,25-OH2, we found a significant and independent (controlled for age, season and pathogen) negative correlation to pneumonia severity. Therefore, supplementation of non-activated vitamin D to protect from pneumonia may be non-sufficient in patients that have a decreased capacity to hydroxylate 25-OH to 1,25-OH2. | yes |
24,774,474 | Are most domains of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 reliable? | {
"contexts": [
"The study's aim was to assess the internal reliability for the nine domains of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) to evaluate homogeneity across clinical studies and whether sample characteristics predict coefficient hetero... | Most domains on the EORTC QLQ-C30 are reliable and may therefore be used to help inform decision-making processes, such as those involving individual patients. | yes |
24,755,031 | Does spanish adaptation of the internal functioning of the Work team Scale ( QFI-22 )? | {
"contexts": [
"The aim of this article is to develop the Spanish adaptation of the internal functioning of Work Teams Scale (QFI-22).",
"The scale was adapted from the French version, and was applied to a sample of 1,055 employees working for firms operating in Spain. The article analyses the internal struc... | The QFI-22 scale is a useful instrument for assessing the internal functioning of work teams. | yes |
24,759,203 | Is image more than a uniform : the promise of assurance? | {
"contexts": [
"The purpose of this qualitative study was to explore the meaning of the phrase \"image of the nurse\" in the context of the desired brand experience of assurance.",
"A brand is a promise that lives in the minds of consumers. Nurses play a key role in delivering on the brand promise of a hospi... | Overall appearance and behaviors define the image of nurses and contribute significantly to the brand of assurance. | yes |
24,759,208 | Do physiologic doses of depot-medroxyprogesterone acetate increase acute plasma simian HIV viremia or mucosal virus shedding in pigtail macaques? | {
"contexts": [
"Epidemiologic studies remain inconclusive on whether the injectable contraceptive depot-medroxyprogesterone acetate (DMPA) increases mucosal HIV shedding and transmissibility. Nonhuman primate models may help to determine the effects of DMPA on acute HIV replication.",
"We defined a physiolog... | In this pigtail macaque model of DMPA and vaginal SHIV infection, we found little or no effect of DMPA on plasma viremia and mucosal virus shedding during acute infection. These results do not support a role of DMPA in increasing mucosal HIV shedding. | no |
24,755,923 | Are haemorrhoids associated with internal iliac vein reflux in up to one-third of women presenting with varicose veins associated with pelvic vein reflux? | {
"contexts": [
"To determine the prevalence of haemorrhoids in women with pelvic vein reflux, identify which pelvic veins are associated with haemorrhoids and assess if extent of pelvic vein reflux influences the prevalence of haemorrhoids.",
"Females presenting with leg varicose veins undergo duplex ultraso... | There is a strong association between haemorrhoids and internal Iliac vein reflux. Untreated reflux may be a cause of subsequent symptomatic haemorrhoids. Treatment with methods proven to work in conditions caused by pelvic vein incompetence, such as pelvic vein embolisation and foam sclerotherapy, could be considered. | yes |
24,749,363 | Does [ REGgamma promote malignant behaviors of lung cancer cells ]? | {
"contexts": [
"To determine the expression of proteasome aotivator gamma (REGgamma) in human lung cancer tissues and cell lines and its association with malignant biological behaviors.",
"Immunohistochemistry (IHC) was used to detect the expression of REGgamma in lung cancer and normal lung tissues. The exp... | REGgamma facilitates malignant biological behaviors of lung cancers. | yes |
24,748,402 | Does the mu opioid receptor activation affect ischemia-induced agonal currents in rat spinal ventral horn? | {
"contexts": [
"Opioid-induced spastic paraplegia after transient spinal cord ischemia during aortic surgery has been reported. Opioids modulate neurotransmission through mu (μ) opioid receptors (MORs) in the spinal ventral horn. However, their effects during ischemic insult are not understood.",
"The effect... | Activation of MORs does not influence ongoing ischemia-induced neuronal death. Our findings indicate that MOR agonist administration should be suitable as an anesthetic during aortic surgery. | no |
24,768,598 | Does improving search over Electronic Health Records using UMLS-based query expansion through random walk? | {
"contexts": [
"Most of the information in Electronic Health Records (EHRs) is represented in free textual form. Practitioners searching EHRs need to phrase their queries carefully, as the record might use synonyms or other related words. In this paper we show that an automatic query expansion method based on th... | Our analysis shows that the success of our method is due to the automatic expansion of the query with extra terms, even when they are not directly related in the UMLS Metathesaurus. The terms added in the expansion go beyond simple synonyms, and also add other kinds of topically related terms. | yes |
24,755,661 | Does hospital Case Volume be Associated With Improved Survival for Patients With Metastatic Melanoma? | {
"contexts": [
"Hospital case volume has been shown to be a predictor of patient mortality for treatment for various cancers. The influence of hospital case volume on malignant melanoma survival and treatment utilization is unknown.",
"We used the Surveillance, Epidemiology, and End Results-Medicare linked d... | For patients diagnosed with metastatic melanoma, being treated in a high-volume hospital was associated with an improvement in survival and lower utilization of chemotherapy, immunotherapy, surgery, and radiation therapy. | yes |
24,769,178 | Is n-acetyl-l-methionine a superior protectant of human serum albumin against photo-oxidation and reactive oxygen species compared to N-acetyl-L-tryptophan? | {
"contexts": [
"Sodium octanoate (Oct) and N-acetyl-l-tryptophan (N-AcTrp) are widely used as stabilizers during pasteurization and storage of albumin products. However, exposure to light photo-degrades N-AcTrp with the formation of potentially toxic compounds. Therefore, we have examined the usefulness of N-ace... | The weakly bound N-AcMet is a superior protectant of albumin, because it is a better ROS-protector and structural stabilizer than N-AcTrp, and it is probable and also useful for other protein preparations. | yes |
24,761,785 | Is arecoline cytotoxic for human endothelial cells? | {
"contexts": [
"Oral submucous fibrosis is a pre-malignant fibrotic condition caused by areca nut use and involves reduced mucosal vascularity. Arecoline is the principal areca nut alkaloid and is cytotoxic for epithelium and fibroblasts. Endothelial cell cycle arrest is reported on exposure to arecoline, as is ... | Arecoline is cytotoxic via necrosis for endothelium, while biochemical assays indicate no appreciable cellular leakage before death and detachment, as well as no clear effect on mitochondrial function in viable cells. Arecoline toxicity may thus contribute to reduced vascularity in oral submucous fibrosis. | yes |
24,755,140 | Do parents as moderators of longitudinal associations between sexual peer norms and Dutch adolescents ' sexual initiation and intention? | {
"contexts": [
"The present study investigated how parents and peers interact in promoting or delaying Dutch adolescents' sexual initiation and intention and focused specifically on parents as moderators of peer influence.",
"Using a longitudinal design, two waves of online questionnaire data were collected ... | Our findings show that different types of sexual peer norms and both general and sexuality-specific parenting play an important role in the early stages of Dutch adolescents' sexual trajectories. Moreover, parent-adolescent communication about sexuality can function as a buffer for the sex-stimulating effects of sexual... | yes |
24,755,147 | Does bisphenol A increase atherosclerosis in pregnane X receptor-humanized ApoE deficient mice? | {
"contexts": [
"Bisphenol A (BPA) is a base chemical used extensively in many consumer products. BPA has recently been associated with increased risk of cardiovascular disease (CVD) in multiple large-scale human population studies, but the underlying mechanisms remain elusive. We previously reported that BPA act... | These findings identify a molecular mechanism that could link BPA exposure to increased risk of CVD in exposed individuals. PXR is therefore a relevant target for future risk assessment of BPA and related environmental chemicals in humans. | yes |
24,768,108 | Does lithium increase nitric oxide levels in subjects with bipolar disorder during depressive episodes? | {
"contexts": [
"Altered nitric oxide (NO) signaling has been associated with the pathophysiology of Bipolar Disorder (BD), directly affecting neurotransmitter release and synaptic plasticity cascades. Lithium has shown to regulate NO levels in preclinical models. However, no study has addressed peripheral NO lev... | The present findings suggest that lithium upregulates NO signaling in unmedicated BD with short illness duration. Further studies with larger samples are needed to confirm the effects of lithium on NO pathway and its association with synaptic plasticity and therapeutics of BD. | yes |
24,749,959 | Does olmesartan prevent cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and p53? | {
"contexts": [
"Cardiac rupture is a catastrophic complication that occurs after acute myocardial infarction (MI) and, at present, there are no effective pharmacological strategies for preventing this condition. Here we investigated the effect of the angiotensin II receptor blocker olmesartan (Olm) on post-infar... | Olm prevents cardiac rupture through inhibition of apoptosis and inflammation, which is attributable to the down-regulation of p53 activity and up-regulation of GDF-15. Our findings suggest that early administration of an AT1 receptor anatagonist to patients with acute MI is a potential preventive approach for cardiac ... | yes |
24,752,159 | Is surgical strategy for the gastric gastrointestinal stromal tumors ( GISTs ) larger than 5 cm : laparoscopic surgery feasible , safe , and oncologically acceptable? | {
"contexts": [
"The efficacy and feasibility of laparoscopic surgery (LAP) for gastric GISTs >5 cm has not been adequately assessed. Here we investigated the clinical outcomes of these patients.",
"Twenty-seven consecutive patients who underwent resection for gastric GISTs >5 cm were enrolled in this retrosp... | In patients with gastric GISTs >5 cm, LAP can be performed with outcomes equivalent to those of OPEN if patient selection and intraoperative judgment are appropriate. | yes |
24,748,164 | Is γ-Glutamyltranspeptidase a prognostic marker of survival and recurrence in radiofrequency-ablation treatment of hepatocellular carcinoma? | {
"contexts": [
"Serum γ-glutamyltranspeptidase (GGT) level, which is often elevated in hepatocellular carcinoma (HCC), has now been found to be an oxidative stress marker which correlates with inflammation in the extracellular hepatic microenvironment. The aim of this study was to investigate the prognostic sign... | Serum GGT is a convenient prognostic biomarker related to OS and recurrence in HCC patients undergoing RFA treatment. | yes |
24,776,569 | Do soft-tissue response rate to chin skeletal advancement in patients with lower facial burn scar? | {
"contexts": [
"This study aimed to evaluate the long-term outcomes and the soft-tissue response to osseous genioplasty in patients with chin retrusion caused by early life facial burn injury.",
"Twenty-two consecutive patients with retrusive chin as a result of severe childhood facial burn were included in ... | Burn-related retrusive chin can appropriately be treated with sliding osseous genioplasty and will require slight overcorrection compared with patients without a history of lower face burn. | yes |
24,749,543 | Does inhibition of proteasome-mediated glucocorticoid receptor degradation restore nitric oxide bioavailability in myocardial endothelial cells in vitro? | {
"contexts": [
"Glucocorticoids (GCs), including the synthetic GC derivate dexamethasone, are widely used as immunomodulators. One of the numerous side effects of dexamethasone therapy is hypertension arising from reduced release of the endothelium-derived vasodilator nitric oxide (NO).",
"Herein, we describ... | Summarising our results, we propose a new mechanism involved in the regulation of NO signalling by GCs in myocardial endothelial cells. We suggest that a sufficient GR protein expression plays a crucial role for the management of GC-induced harmful adverse effects, including deregulations of vasorelaxation arising from... | yes |
24,753,128 | Is randomization associated with socio-economic and demographic factors in a multi-center clinical trial of children with sickle cell anemia? | {
"contexts": [
"Few studies have investigated factors influencing participation rates for minority children with a chronic disease in clinical trials. The Silent Cerebral Infarct Multi-Center Clinical (SIT) Trial provides an opportunity to study the impact of demographic and socio-economic factors on randomizati... | In the SIT Trial, acceptance of random allocation was not associated with socio-economic or demographic factors. Although these factors may represent barriers for some participants, they should not bias investigators caring for children with SCD in their approach to recruitment for clinical trial participation. | no |
24,754,296 | Does technical challenge encountered during deployment of the ovation abdominal aortic stent-graft system? | {
"contexts": [
"To describe technical challenges encountered using the Ovation endograft for abdominal aortic aneurysms and suggest tips and maneuvers for successful management.",
"Deployment of the Ovation's unsupported main body is often associated with the anteroposterior arrangement of the limb gates ins... | Awareness of certain aspects associated with the use of the Ovation device and adoption of the adjunctive techniques herein described helps the interventionist avoid unexpected challenges or manage technical difficulties to maximize the device's safety and effectiveness. | yes |
24,754,501 | Does recovery from neuromuscular block in dogs : restoration of spontaneous ventilation exclude residual blockade? | {
"contexts": [
"To evaluate if return of spontaneous ventilation to pre-relaxation values indicates complete recovery from neuromuscular blockade.",
"Prospective, with each individual acting as its own control.",
"Ten healthy adult female Beagle dogs weighing 6.2-9.4 kg.",
"Dogs were anesthetized wit... | Significant residual neuromuscular block could be measured at the hind limb with acceleromyography when ventilation had spontaneously returned to pre-vecuronium values. Monitoring spontaneous ventilation, including end-tidal CO2 , expired tidal volume, peak inspiratory flow or minute ventilation cannot be used as a sur... | no |
24,748,531 | Does co-ingestion of caffeine and carbohydrate after meal improve performance at high-intensity intermittent sprints with short recovery times? | {
"contexts": [
"To determine the effects of co-ingesting caffeine (CAF) and carbohydrate (CHO) on high-intensity intermittent sprints (HIS) performance and physiological responses.",
"Twelve active males underwent 4 interventions at least 7 days apart in a randomized, double-blind, placebo-controlled, balanc... | Co-ingestion of CAF and CHO did not improve high-intensity sprint cycling performance or reduce fatigue in active males. Moreover, combined CAF and CHO supplementation might facilitate catabolism during prolonged high-intensity intermittent exercise. | no |
24,748,530 | Does combining heat stress and moderate hypoxia reduce cycling time to exhaustion without modifying neuromuscular fatigue characteristics? | {
"contexts": [
"This study investigated the isolated and combined effects of heat [temperate (22 °C/30 % rH) vs. hot (35 °C/40 % rH)] and hypoxia [sea level (FiO2 0.21) vs. moderate altitude (FiO2 0.15)] on exercise capacity and neuromuscular fatigue characteristics.",
"Eleven physically active subjects cycl... | Moderate hypoxia in combination with heat stress reduces cycling time to exhaustion without modifying neuromuscular fatigue characteristics. Impaired oxygen delivery or increased cardiovascular strain, increasing relative exercise intensity, may have also contributed to earlier exercise cessation. | yes |
24,749,665 | Do extended high-frequency ( 9-20 kHz ) audiometry reference thresholds in 645 healthy subjects? | {
"contexts": [
"The aim of the present study was to study patterns in the extended spectrum of the human hearing (0.125 to 20 kHz) in order to obtain reference thresholds. Then, we compare our values with existing results at extended high-frequencies (8 to 20 kHz) in an attempt to establish new standards for pot... | When comparing different studies the hearing thresholds were found to be similar. Therefore, it would be possible to establish international standard thresholds. | yes |
24,746,881 | Does inhibition of peripheral FAAH depress activities of bladder mechanosensitive nerve fibers of the rat? | {
"contexts": [
"FAAH degrades endocannabinoids and fatty acid amides. FAAH inhibition reduces micturition frequency and counteracts bladder overactivity in rats. We studied the effects of the peripherally active selective FAAH inhibitor URB937, and the CB1 and CB2 receptor antagonists rimonabant and SR144528, re... | To our knowledge we report for the first time that inhibiting peripheral FAAH depresses the Aδ and C-fiber activity of primary bladder afferents via CB1 and CB2 receptors. CB antagonists alone exerted facilitatory effects on single unit afferent activity during bladder filling in rats. The endocannabinoid system may be... | yes |
24,760,622 | Are soluble Klotho levels in adult renal transplant recipients modulated by recombinant human erythropoietin? | {
"contexts": [
"Data on serum soluble Klotho levels in chronic kidney disease are contradictory and even less is known after renal transplantation. Experimental studies demonstrated that recombinant human erythropoietin (rhEPO) treatment mitigates Klotho reduction caused by renal damage. Therefore, this study ai... | Our results demonstrate that KTR have higher serum Klotho levels than HS and that rhEPO treatment modulates these concentrations, suggesting a link between rhEPO and soluble Klotho in KTR. | yes |
24,768,615 | Does dual tasking during postural stepping responses increase falls but not freezing in people with Parkinson 's disease? | {
"contexts": [
"Although falls in people with Parkinson's disease (PD) associate with dual tasking and freezing of gait (FoG), it is not known whether falls during dual tasking are due to FoG. This study investigated the effects of a cognitive task on the occurrence of falls and FoG when subjects with PD step in... | For people with PD and FoG, forward falls may not always be caused by FoG, particularly under attention-distracting conditions. | yes |
24,746,977 | Does physical exercise antagonize clinical and anatomical features characterizing Lieber-DeCarli diet-induced obesity and related metabolic disorders? | {
"contexts": [
"Lieber-DeCarli diet has been used to induce obesity and non-alcoholic steatohepatitis (NASH). As scarce anatomical and clinical-related information on this diet model exists and being exercise an advised strategy to counteract metabolic diseases, we aimed to analyze the preventive (voluntary phys... | ET used as a therapeutic tool mitigated the clinical/anatomical-related features induced by Liber-DeCarli diet, thus possibly contributing to control obesity and metabolic disorders. | yes |
24,748,780 | Do public-private partnerships improve health outcomes in individuals with early stage Alzheimer 's disease? | {
"contexts": [
"In a collaborative effort between the Missouri Department of Health, Area Agencies on Aging (AAA), Alzheimer Association, and academic researchers, we tested whether early dementia detection and comprehensive care consultations would improve health outcomes in care receivers (CRs) and their famil... | PLM was successful in improving detection of incident cases of dementia in the community and in connecting patients and their families with needed services. Our findings support the use of state agencies and community service partners to detect dementia. Early implementation of psychosocial interventions could have sig... | yes |
24,750,470 | Does local injection of vasopressin reduce the blood loss during cesarean section in placenta previa? | {
"contexts": [
"The aim of this study was to evaluate the effect of local injection of vasopressin on blood loss and secondary impact on complications during cesarean section in patients with placenta previa.",
"We retrospectively reviewed the medical records of all patients diagnosed with placenta previa ad... | The local injection of vasopressin into the placental implantation site significantly reduced the blood loss without increasing the morbidity. | yes |
24,751,363 | Does topical application of Kochia scoparia inhibit the development of contact dermatitis in mice? | {
"contexts": [
"Kochia scoparia (Chenopodiaceae) has been reported to have anti-nociceptive, anti-inflammatory, anti-allergic, and anti-pruritic actions. This study investigated the anti-inflammatory effects of externally applied Kochia scoparia water extract (KSW) in 2,4-dinitrochlorobenzene (DNCB)-induced cont... | These findings indicated that KSW ameliorates contact dermatitis via inhibition of the production of several inflammatory mediators. Therefore, external application of KSW may be used for the treatment of contact dermatitis as an alternative therapy. | yes |
24,751,364 | Does preconditioning with the traditional Chinese medicine Huang-Lian-Jie-Du-Tang initiate HIF-1α-dependent neuroprotection against cerebral ischemia in rats? | {
"contexts": [
"Huang-Lian-Jie-Du-Tang (HLJDT) is a classical heat-clearing and detoxicating formula of traditional Chinese medicine that is widely used to treat stroke. The present study was designed to investigate the effects of HLJDT preconditioning on neurons under oxygen and glucose deprivation (OGD) and ra... | Both rats and neurons subjected to HLJDT preconditioning were able to resist ischemia/reperfusion or hypoxia injury through the inhibition of apoptosis and the enhancement of proliferation, and these effects were primarily dependent on the activation of the PI3K/Akt signaling pathway and HIF-1α. | yes |
24,751,369 | Does information-enhancement and goal setting techniques for increasing adaptive motivation and decreasing urge to drink alcohol? | {
"contexts": [
"The aim of the study was to determine whether experimental manipulation of sense of control would change moderate drinkers' (N=106) task-specific motivational structure and explicit and implicit determinants of their urge to drink alcohol.",
"The effects of various levels of information-enhan... | The results show that sense of control can be experimentally induced. This finding has important clinical implications. | yes |
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