pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
25,091,988 | Does sunitinib mesylate inhibit proliferation of human colonic stromal fibroblasts in vitro and in vivo? | {
"contexts": [
"Cancer stromal fibroblasts are important members of the cancer microenvironment. In this study, we determined the effect of sunitinib, a small molecule tyrosine kinase inhibitor, on the primary human colonic fibroblasts.",
"Cell cycle analysis and cell proliferation assays were performed to e... | Sunitinib mesylate inhibited the proliferation of primary human colonic fibroblasts through target-inhibited PDGFR signaling in vitro and in vivo. | yes |
25,082,616 | Does sports-related concussion increase the risk of subsequent injury by about 50 % in elite male football players? | {
"contexts": [
"Little is known about the short-term and long-term sequelae of concussion, and about when athletes who have sustained such injuries can safely return to play.",
"To examine whether sports-related concussion increases the risk of subsequent injury in elite male football players.",
"Prospec... | Concussion was a risk factor for sustaining subsequent injury within the following year. In-depth medical evaluation, which includes neurological and cognitive assessment, is warranted within the concussion management and return-to- play process. | yes |
25,073,778 | Is intracavitary physiotherapy inferior to endometrial scratching in patients with recurrent implantation failure? | {
"contexts": [
"To investigate whether intracavitary physiotherapy is superior to endometrial scratching in patients with recurrent implantation failure (RIF) after in vitro fertilization/intracytoplasmic sperm injection- embryo transfer (IVF/ICSI-ET) cycles.",
"According to the inclusion criteria defined by... | Intracavitary physiotherapy is not inferior to endometrial scratching on improving implantation and clinical pregnancy rates in patients with RIF after IVF/ICSI cycles. | no |
25,097,079 | Does vaccination against zoster remain effective in older adults who later undergo chemotherapy? | {
"contexts": [
"Approximately 40% of adults develop invasive cancer during their lifetimes, many of whom require chemotherapy. Herpes zoster (HZ) is common and often severe in patients undergoing chemotherapy, yet there are no data regarding whether these patients retain specific protection against HZ if they ha... | Zoster vaccine continues to protect against HZ if recipients later undergo chemotherapy. Our findings provide an additional rationale for offering zoster vaccine to indicated adults while they are immunocompetent. | yes |
25,093,408 | Are obesity-related genomic loci associated with type 2 diabetes in a Han Chinese population? | {
"contexts": [
"Obesity is a well-known risk factor for type 2 diabetes. Genome-wide association studies have identified a number of genetic loci associated with obesity. The aim of this study is to examine the contribution of obesity-related genomic loci to type 2 diabetes in a Chinese population.",
"We suc... | This study indicates that obesity-related genomic loci were associated with type 2 diabetes and glycemic traits in the Han Chinese population. | yes |
25,075,034 | Does high oxygen partial pressure increase photodynamic effect on HeLa cell lines in the presence of chloraluminium phthalocyanine? | {
"contexts": [
"Photodynamic therapy (PDT) is linked with oxidative damage of biomolecules causing significant impairment of essential cellular functions that lead to cell death. It is the reason why photodynamic therapy has found application in treatment of different oncological, cardiovascular, skin and eye di... | These results demonstrate that the photodynamic effect in cervical cancer cells utilizing ClAlPcS2 significantly depends on oxygen level. | yes |
25,076,244 | Is bRAF mutation analysis a valid tool to implement in Lynch syndrome diagnosis in patients classified according to the Bethesda guidelines? | {
"contexts": [
"Lynch syndrome (LS) is clinically defined by the Amsterdam criteria (AC) and by germline mutations in mismatch-repair (MMR) genes leading to microsatellite instability (MSI) at the molecular level. Patients who do not fulfil AC are considered suspected-Lynch according to the less stringent Bethes... | The prevalence of BRAF mutations in CRC patients is not high but extremely correlated with MSI and risk categories as BG, whereas they are absent in LS patients. BRAF mutation detection can reduce the need for MMR gene analysis in a small (but not negligible) proportion of MSI patients (7%), with a positive impact on t... | yes |
25,081,571 | Do s-aryl-L-cysteine sulphoxides and related organosulphur compounds alter oral biofilm development and AI-2-based cell-cell communication? | {
"contexts": [
"To design and synthesize a library of structurally related, small molecules related to homologues of compounds produced by the plant Petiveria alliacea and determine their ability to interfere with AI-2 cell-cell communication and biofilm formation by oral bacteria. Many human diseases are associ... | Due to the structural similarity of these compounds to each other, and to key molecules in AI-2 biosynthetic pathways, we propose that these molecules potentially reduce biofilm formation via antagonism of QS or QS-related pathways. | yes |
25,091,089 | Is the covariation between burnout and sick leave due to mental disorders explained by a shared genetic liability : a prospective swedish twin study with a five-year follow-up? | {
"contexts": [
"This study aims to assess whether the associations between burnout and sick leave due to stress-related mental disorders, other mental disorders, and somatic conditions are influenced by familial (genetic and shared environmental) factors.",
"In this prospective cohort study, 23,611 Swedish t... | The association between burnout and sick leave due to stress-related and other mental disorders seems to be a reflection of a shared genetic liability. | yes |
25,091,082 | Does dental anxiety screening practices and self-reported training need among Australian dentists? | {
"contexts": [
"It is recommended that dentists screen for dental anxiety (DA) so that fearful patients may be better managed. The main aim of this study was to determine what dentists are being taught in relation to DA as well as whether and how anxious patients are identified in the clinic.",
"Two hundred ... | The use of formal, validated scales for screening DA is minimal. Training in anxiety management appears to be low and is an area that could be expanded upon. | yes |
25,099,429 | Do mental health service use among high school students exposed to interpersonal violence? | {
"contexts": [
"Violence-exposed youth rarely receive mental health services, even though exposure increases risk for academic and psychosocial problems. This study examines the association between violence exposure and mental health service contact. The 4 forms of violence exposure were peer, family, sexual, an... | Associations between adolescent violence exposure and mental health service contact vary by forms of exposure. Outreach to a broader set of exposed youth may reduce the impact of violence and its consequences for vulnerable students. | yes |
25,090,928 | Does prognostic significance of MSI2 predict unfavorable outcome in adult B-acute lymphoblastic leukemia? | {
"contexts": [
"The Musashi-2 gene (MSI2) is implicated in leukemogenesis, and high MSI2 expression has been associated with decreased survival in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), suggesting its use as a new prognostic marker. We aimed to validate the prognostic significance of MSI... | These results confirm the association of MSI2 expression with outcome in adult B-ALL and demonstrate the utility of MSI2 as a clinical prognostic biomarker. | yes |
25,085,279 | Does liver transcript analysis reveal aberrant splicing due to silent and intronic variations in the ABCB11 gene? | {
"contexts": [
"Progressive familial intrahepatic cholestasis type 2 (PFIC2) is an autosomal recessive disease due to mutations in ABCB11. ABCB11 encodes the bile salt export pump (BSEP), the major transporter responsible for biliary bile acid secretion, which expression is restricted to hepatocytes. In some pat... | ABCB11 liver transcript analysis is a useful tool to confirm or invalidate the predicted splicing effect of a silent or intronic ABCB11 variation. | yes |
25,084,111 | Are arterial stiffness and pulse wave reflection increased in patients suffering from severe periodontitis? | {
"contexts": [
"This single blind cross-sectional study compared the vascular health of subjects suffering from severe chronic periodontitis, severe aggressive periodontitis and periodontal healthy controls by evaluating pulse wave velocity (PWV), augmentation index (AIx) and pulse pressure amplification (PPA)."... | The results of this study confirm the association between periodontal inflammation and increased cardiovascular risk shown by impaired vascular health in case of severe periodontitis. As impaired vascular health is a common finding in patients suffering from severe periodontal disease a concomitant routine cardiovascul... | yes |
25,096,233 | Do somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma? | {
"contexts": [
"Cisplatin-based chemotherapy is the standard of care for patients with muscle-invasive urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based chemotherapy is associated with improved survival, although molecular determinants of cisplatin response are incomplete... | Somatic ERCC2 mutations correlate with complete response to cisplatin-based chemosensitivity in muscle-invasive urothelial carcinoma, and clinically identified mutations lead to cisplatin sensitivity in vitro. Nucleotide excision repair pathway defects may drive exceptional response to conventional chemotherapy. | yes |
25,096,231 | Does preoperative anemia increase mortality and postoperative morbidity after cardiac surgery? | {
"contexts": [
"Anemia is an established adverse risk factor in cardiovascular disease. However, the effect of preoperative anemia is not well defined in heart surgery. This study evaluates the effect of preoperative anemia on early clinical outcomes in patients undergoing cardiac surgery.",
"A retrospective... | In patients undergoing heart surgery, preoperative anemia is associated with an increased risk of mortality and postoperative morbidity. | yes |
25,101,167 | Does vEGFR-1 blockade disrupt peri-implantation decidual angiogenesis and macrophage recruitment? | {
"contexts": [
"Angiogenesis and macrophage recruitment to the uterus are key features of uterine decidualization; the progesterone-mediated uterine changes that allow for embryo implantation and initiation of pregnancy. In the current study, we characterized the expression of vascular endothelial growth factor ... | We found that VEGFR-1 functions in both decidual angiogenesis and macrophage recruitment to the implantation site during pregnancy. VEGFR-1 is expressed by endothelial cells, however blocking VEGFR-1 function in endothelial cells results in reduced macrophage recruitment to the uterus. VEGFR-1 blockade did not compromi... | yes |
25,085,604 | Are operating lung volumes affected by exercise mode but not trunk and hip angle during maximal exercise? | {
"contexts": [
"Despite VO₂peak being, generally, greater while running compared to cycling, ventilation (VE) during maximal exercise is less while running compared to cycling. Differences in operating lung volumes (OLV) between maximal running and cycling could be one explanation for previously observed differe... | Since OLV are altered by exercise mode, but cycling position did not have a significant impact on OLV, we conclude that trunk/hip angle is likely not the primary factor determining OLV during maximal exercise. | yes |
25,076,161 | Does rifaximin suppress background intestinal 18F-FDG uptake on PET/CT scans? | {
"contexts": [
"Identification of cancer or inflammatory bowel disease in the intestinal tract by PET/computed tomography (CT) imaging can be hampered by physiological uptake of F-fluorodeoxyglucose (F-FDG) in the normal colon. Previous work has localized this F-FDG uptake to the intestinal lumen, predominantly ... | This pilot study shows that treatment with rifaximin for 2 days before PET/CT scanning can significantly reduce physiological F-FDG uptake in the normal colonic lumen. | yes |
25,076,163 | Is [ Venous Access Port Implantation an Ideal Teaching Operation - An Analysis of 1423 Cases ]? | {
"contexts": [
"The aim of this study was the analysis of total, early and late complications following venous access port implantation between 1998 and 2008 at the Department of Surgery of the University of Rostock, Germany. A comparison between different implantation techniques addressing success rate, complic... | Venous port implantation is a relatively simple procedure despite its possible complications. An open access technique is safer than puncture. The rate of complications significantly decreases with increasing number of performed operations. Therefore venous port implantation and especially the open access method is an ... | yes |
25,075,101 | Is minichromosome maintenance protein 7 a risk factor for recurrence in patients with Dukes C colorectal cancer? | {
"contexts": [
"It has been hypothesized that minichromosome maintenance (MCM) proteins, which are replicative control factors, can be used to detect tumor proliferation. The aim of the present study was to investigate the expression of MCM in colorectal cancer tissues and correlate it to clinical outcomes.",
... | We found that the expression of MCM7 is an independent risk factor for RFS in patients with Dukes C colorectal cancer. Further studies are required to investigate the validity of MCM7 protein expression for its potential clinical use in colorectal cancer therapy and prognosis. | yes |
25,088,248 | Is obesity associated with a poorer prognosis in women with hormone receptor positive breast cancer? | {
"contexts": [
"Whether moderate to severe obesity (body mass index (BMI)≥30 to <40kg/m(2)) contributes to breast cancer recurrence and mortality remains uncertain.",
"1199 women, recruited within 12 months of their diagnosis of hormone receptor positive (HR+), human epidermal growth factor receptor 2 negati... | Moderate to severe obesity is associated with a poorer invasive breast cancer prognosis; this is also true for women with Stage 1 disease, and is independent of age and treatment. | yes |
25,080,090 | Does integrative analysis reveal disease-associated genes and biomarkers for prostate cancer progression? | {
"contexts": [
"Prostate cancer is one of the most common complex diseases with high leading cause of death in men. Identifications of prostate cancer associated genes and biomarkers are thus essential as they can gain insights into the mechanisms underlying disease progression and advancing for early diagnosis ... | The successful results on prostate cancer samples demonstrated that the integrative analysis is powerful and useful approach to detect candidate disease-associate genes and modules which can be used as the potential biomarkers for prostate cancer progression. The data, tools and supplementary files for this integrative... | yes |
25,080,093 | Does choice of non-inferiority ( NI ) margins protect against degradation of treatment effects on an average -- an observational study of registered and published NI trials? | {
"contexts": [
"NI margins have to be chosen appropriately to control the risk of degradation of treatment effects in non-inferiority (NI) trials. We aimed to study whether the current choice of NI margins protects sufficiently against a degradation of treatment effect on an average.",
"NI trials reflecting ... | Only two fifths of the current NI trials had a likelihood of degradation lower than 50%, suggesting that, in majority of the NI trials, there is no sufficient protection against degradation on an average. We suggest a third hurdle for the choice of NI margins, thus contributing a sufficient degree of protection. | no |
25,073,668 | Do [ Factors influencing the miss rate of polyps in a tandem colonoscopy study ]? | {
"contexts": [
"The miss rate of colon polyps and its related factors have not been clearly identified yet. This study aims to review the miss rate of polyps both on the patient-level and on the polyp-level and to analyze the factors affecting the miss rate such as those related to the endoscopist, procedure, pa... | The experience of endoscopists did not have influence on the accuracy of polyp detection. However, the fatigue of endoscopists in the afternoon is considered to render polyp detection less accurate. Also, the large curves and folds of the sigmoid colon are regarded as a reason for the higher miss rate of polyps in the ... | yes |
25,098,913 | Does metal debris concentrations in soft tissues adjacent to loosened femoral stem is higher in uncemented than cemented implants? | {
"contexts": [
"There are still many questions related to aseptic femoral stem loosening. Systemic and local immune responses to the implanted \"foreign body\" is one of the reasons for loosening. The purpose of the study was to measure metal ion concentration (Ti, Co, Cr, Mo, Ni, Al) around loosened femoral ste... | In soft tissue around a loosened stem, the concentrations of metal ions from implants are much higher in case of uncemented stems than of cemented ones. Metal ions from vitalium femoral heads were found around uncemented stems in similar values to cemented streams. | yes |
25,082,024 | Does classification of patients with breast cancer according to Nottingham prognostic index highlight significant differences in immunohistochemical marker expression? | {
"contexts": [
"Prognosis and treatment of patients with breast carcinoma of no special type (NST) is dependent on a few established parameters, such as tumor size, histological grade, lymph node stage, expression of estrogen receptor, progesterone receptor, and HER-2/neu, and proliferation index. The original N... | These data confirm that the original, three-tiered NPI statistically correlates with the expression of prognostic immunohistochemical markers in breast carcinoma NST. | yes |
25,085,498 | Do prior hematologic conditions carry a high morbidity and mortality in patients supported with continuous-flow left ventricular assist devices? | {
"contexts": [
"Mechanical support leads to an increased risk of both bleeding and thrombotic events, but little is known about the risk of device support in patients with a baseline predisposition to these events. The aim of this study was to examine outcomes among patients with baseline hematologic conditions ... | Patients with a history of prior hematologic conditions are at high risk for bleeding, thrombotic and neurologic events during device support, leading to early mortality. This case series questions the benefit of CF-LVAD in these patients and the appropriate management with regard to anti-coagulation. Further studies o... | yes |
25,074,691 | Is mRI-detected subclinical joint inflammation associated with radiographic progression? | {
"contexts": [
"We recently demonstrated that MRI inflammation is prevalent in clinically non-swollen joints of early arthritis patients. In this study, we assessed the relevance of this subclinical inflammation with regard to radiographic progression.",
"1130 joints (unilateral metacarpophalangeal 2-5, wris... | Radiographic progression was infrequent, but joints with subclinical inflammation had an increased risk of radiographic progression within year 1. This demonstrates the relevance of MRI-detected subclinical inflammation. | yes |
25,087,835 | Are repeated dyspnea score and percent FEV1 modest predictors of hospitalization/relapse in patients with acute asthma exacerbation? | {
"contexts": [
"(1) Compare ideal cut-off points for DS and %FEV1 at 1 and 3 h to predict hospitalization/relapse in subjects with moderate to severe asthma exacerbation (2) Develop a multivariate regression model using DS, %FEV1, demographic, and clinical variables to predict hospitalization/relapse.",
"Sub... | The 3-h score for %FEV1 and DS performed better than scores at any other time point and better than either parameter over time. The 3-h DS had the greatest association with the composite outcome. Neither test was a strong enough predictor to be used solely for this purpose. | yes |
25,088,333 | Does mucinous differentiation impact stage or risk of recurrence among patients with grade 1 , endometrioid type , endometrial carcinoma? | {
"contexts": [
"To evaluate whether the presence of mucinous differentiation influences histopathologic findings, stage distribution, or rate of recurrence among women with grade 1, endometrioid type, endometrial carcinoma.",
"This was a retrospective cohort study of all patients with grade 1, endometrioid t... | In the setting of grade 1, endometrioid type, endometrial carcinoma, mucinous differentiation is more common in older patients and is associated with an increased likelihood of myometrial invasion. However, stage distribution and risk of recurrence are not affected. | no |
25,093,167 | Does combined analysis with copy number variation identify risk loci in lung cancer? | {
"contexts": [
"Lung cancer is the most important cause of cancer mortality worldwide, but the underlying mechanisms of this disease are not fully understood. Copy number variations (CNVs) are promising genetic variations to study because of their potential effects on cancer.",
"Here we conducted a pilot stu... | Our results further emphasized the importance of copy number variations in cancer and might be a valuable complement to current genome-wide association studies on cancer. | yes |
25,077,848 | Are potentially traumatic events and serious life stressors prospectively associated with frequency of doctor visits and overnight hospital visits? | {
"contexts": [
"Cumulative lifetime exposure to potentially traumatic events and serious life stressors has been linked with both mental and physical health problems; however, less is known about the association between exposure to potentially traumatic events and serious life stressors with health care use. We ... | Exposure to potentially traumatic events and serious life stressors is associated with increased doctor visits and nights spent in the hospital, which may have important implications for the current standard of care. | yes |
25,074,712 | Does whole-genome bisulfite sequencing of multiple individuals reveal complementary roles of promoter and gene body methylation in transcriptional regulation? | {
"contexts": [
"DNA methylation is an important type of epigenetic modification involved in gene regulation. Although strong DNA methylation at promoters is widely recognized to be associated with transcriptional repression, many aspects of DNA methylation remain not fully understood, including the quantitative ... | Our results suggest that DNA methylation outside promoters also plays critical roles in gene regulation. Future studies on gene regulatory mechanisms and disease-associated differential methylation should pay more attention to DNA methylation at gene bodies and other non-promoter regions. | yes |
25,071,912 | Is cD64 expression increased in patients with severe acute pancreatitis : clinical significance? | {
"contexts": [
"Upregulated CD64 expression on neutrophils is the most useful marker for acute bacterial infections and systemic inflammation. However, it is unknown whether CD64 is involved in the pathogenesis of acute pancreatitis (AP). This study was designed to determine whether CD64 is implicated in severe ... | The CD64 level was significantly increased in correlation with the disease severity in SAP and may act as a useful marker for predicting the development of SAP. | yes |
25,077,824 | Does glibenclamide attenuate myocardial injury by lipopolysaccharides in streptozotocin-induced diabetic mice? | {
"contexts": [
"Sepsis is a common disease that continues to increase in incidence in the world. Diseases, such as diabetes mellitus, may make the situation worse. Diabetic patients are at increased risk for common infections. This study was designed to investigate the role of glibenclamide on myocardial injury ... | We conclude that glibenclamide could attenuate myocardial injury induced by LPS challenge in STZ-mice, which was possibly related to inhibiting inflammation through Nalp3 inflammasomes. | yes |
25,097,584 | Are maternal mRNA expression levels of H19 inversely associated with risk of macrosomia? | {
"contexts": [
"To investigate the associations between the mRNA levels of H19 in term placenta and risk of macrosomia.",
"Term placentas were collected from 37 macrosomia and 37 matched neonates with normal birth weight (controls) born in Changzhou Women and Children Health Hospital, Jiangsu province, P. R.... | The term placental H19 mRNA levels were inversely related to the occurrence of macrosomia. Our findings suggest that the low expression of H19 mRNA may contribute to the development of macrosomia. | yes |
25,079,790 | Is auranofin highly efficacious against Toxoplasma gondii in vitro and in an in vivo experimental model of acute toxoplasmosis? | {
"contexts": [
"The mainstay of toxoplasmosis treatment targets the folate biosynthetic pathways and has not changed for the last 50 years. The activity of these chemotherapeutic agents is restricted to one lifecycle stage of Toxoplasma gondii, they have significant toxicity, and the impending threat of emerging... | These results reveal in vitro and in vivo activity of auranofin against T. gondii, suggesting that it may be an effective alternative treatment for toxoplasmosis. | yes |
25,079,799 | Does hippocampal laminar distribution of tau relate to Alzheimer 's disease and age of onset? | {
"contexts": [
"Cerebral deposition of phospho-tau in Alzheimer's disease (AD) occurs with varying patterns within hippocampus. Lamina-specific tau changes in AD may reflect trans-synaptic propagation of phospho-tau along neuroanatomical pathways.",
"To study patterns of tau deposition within inner (IML) and... | Phospho-tau pathology, when prominent within both IML and OML, is associated with CERAD diagnosis of Definite AD and earlier age of onset in AD. Laminar patterns of tau deposition reflect regional involvements during disease course. | yes |
25,082,805 | Does larger A1/M1 diameter ratio predict embolic anterior cerebral artery territorial stroke? | {
"contexts": [
"In contrast to middle cerebral artery territory strokes, anterior cerebral artery strokes (ACAS) occur rarely. The low frequency of ACAS, in relation to middle cerebral artery territory strokes, may be explained by differences in ACA and middle cerebral artery anatomy influencing their respective... | Larger ipsilateral A1 diameters and A1/M1 diameter ratio are associated with embolic ACAS. These findings suggest that A1 diameters and M1 diameters are important in determining the path of emboli that reach the terminal internal carotid artery. | yes |
25,078,447 | Does optimal attenuation of experimental autoimmune encephalomyelitis by intravenous immunoglobulin require an intact interleukin-11 receptor? | {
"contexts": [
"Intravenous immunoglobulin (IVIg) has been used to treat a variety of autoimmune disorders including multiple sclerosis (MS); however its mechanism of action remains elusive. Recent work has shown that interleukin-11 (IL-11) mRNAs are upregulated by IVIg in MS patient T cells. Both IVIg and IL-11... | These results implicate IL-11 as an important immune effector of IVIg in the prevention of Th17-mediated autoimmune inflammation during EAE. | yes |
25,097,469 | Does switching from systemic steroids to ciclesonide restore the hypothalamic pituitary-adrenal axis? | {
"contexts": [
"Treatment of difficult asthma with oral corticosteroids (OCS) may suppress the hypothalamic-pituitary-adrenal axis.",
"In this study we have checked if the substitution of OCS with very high doses of ciclesonide may restore the adrenal function without losing the control of the disease.",
... | Switching from prednisone to very high doses of ciclesonide normalized the hypothalamic-pituitary adrenal axis function and also improved the disease control and the lung function in these 5 patients with difficult asthma. | yes |
25,079,460 | Is autoimmune thyroiditis in children and adolescents with type 1 diabetes mellitus associated with elevated IgG4 but not with low vitamin D? | {
"contexts": [
"To assess levels of vitamin D and of immunoglobulin G subclasses in children and adolescents with type 1 Diabetes Mellitus with or without autoimmune thyroiditis.",
"Among 213 patients with type 1 diabetes, the cases with thyroid-specific autoantibodies formed Group 1 [n=19, M/F: 7/12, median... | There was no difference of vitamin D levels between the groups. Only a small percentage of patients with type 1 diabetes also having autoimmune thyroiditis had elevated serum IgG4 levels, revealing the heterogeneity of autoimmune thyroiditis and existence of IgG4 thyroiditis in the pediatric age group. Total IgG, the o... | yes |
25,092,778 | Do somatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation? | {
"contexts": [
"Recurrently mutated genes in myelodysplastic syndrome (MDS) are pathogenic drivers and powerfully associated with clinical phenotype and prognosis. Whether these types of mutations predict outcome after allogeneic hematopoietic stem-cell transplantation (HSCT) in patients with MDS is not known.",... | Mutations in TP53, TET2, or DNMT3A identify patients with MDS with shorter OS after HSCT. | yes |
25,088,238 | Does maternal obesity influence the relationship between location of neonate fat mass and total fat mass? | {
"contexts": [
"It is suggested that maternal obesity perpetuates offspring obesity to future generations.",
"To determine whether location of neonate fat mass (FM: central vs. peripheral) is related to total neonate FM and whether maternal obesity influences this relationship.",
"Neonate body compositio... | The relationship between total FM and location of FM is influenced by maternal obesity. | yes |
25,085,016 | Are cXXC4 mRNA levels associated with clinicopathological parameters and survival of myelodysplastic syndrome patients? | {
"contexts": [
"The CXXC domain protein 4 (CXXC4) functions as a negative regulator of Wnt signaling and also regulates expression of the ten-eleven translocation 2 (TET2) protein for DNA methylation. This study detected levels of CXXC4 and TET2 mRNA to determine their association with survival of patients with ... | This study demonstrated that the age of patients and levels of CXXC4 mRNA, hemoglobin, and marrow blast associated with survival of MDS patients. | yes |
25,086,730 | Is weight training harmful for women with breast cancer-related lymphoedema : a systematic review? | {
"contexts": [
"Is weight-training exercise intervention harmful to women with or at risk of breast cancer-related lymphoedema?",
"Systematic review with meta-analysis of randomised trials.",
"Women with or at risk of breast cancer-related lymphoedema.",
"Progressive weight-training exercise.",
"... | Weight training appears to be safe and beneficial in improving limb strength and physical components of quality of life in women with or at risk of lymphoedema. Pressure garments, supervision and limiting the intensity of the weight training may each be important, but this could not be confirmed with this review. | no |
25,071,077 | Is insulin sensitivity an important determinant of renal health in adolescents with type 2 diabetes? | {
"contexts": [
"Diabetic nephropathy (DN) remains the most common cause of end-stage renal disease and is a major cause of mortality in type 2 diabetes. Insulin sensitivity is an important determinant of renal health in adults with type 2 diabetes, but limited data exist in adolescents. We hypothesized that meas... | A significant proportion of adolescents with type 2 diabetes showed evidence of early DN, and insulin sensitivity, rather than HbA1c, blood pressure, or lipid control, was the strongest determinant of renal health. | yes |
25,071,078 | Are falling insulin requirements associated with adverse obstetric outcomes in women with preexisting diabetes? | {
"contexts": [
"To investigate the clinical significance of falling insulin requirements in women with preexisting or overt diabetes in pregnancy.",
"A retrospective review of 139 pregnancies was conducted in women, with preexisting diabetes, delivering between January 2010 and January 2013. Women with falli... | Falling insulin requirements, in women with preexisting diabetes, are associated with an increased risk of complications related to placental dysfunction. Further prospective studies are needed to guide clinical management. | yes |
25,070,052 | Do miRNAs affect the expression of innate and adaptive immunity proteins in celiac disease? | {
"contexts": [
"microRNAs (miRNAs) are short RNAs that regulate gene expression in various processes, including immune response. Altered immune response is a pivotal event in the pathogenesis of celiac disease (CD), and miRNAs could have a role in modulating both innate and adaptive response to gluten in celiac ... | miRNA expression is significantly altered in duodenal mucosa of CD patients, and this alteration can increase the expression of molecules involved in immune response. | yes |
25,074,447 | Is the BDNF Val ( 66 ) Met polymorphism associated with escitalopram response in depressed patients? | {
"contexts": [
"The brain-derived neurotrophic factor (BDNF) gene is a candidate gene in therapeutic responses to antidepressants. The aim of the study was to determine the effects of BDNF allelic variability on responses to escitalopram treatment at 3 weeks after treatment initiation and at a 6-week endpoint.",... | These findings highlight a significant association between the BDNF valine to methionine substitution (Val(66)Met) polymorphism and the treatment response to escitalopram in a Caucasian population of severely depressed inpatients. | yes |
25,085,452 | Does subthalamic deep brain stimulation improve auditory sensory gating deficit in Parkinson 's disease? | {
"contexts": [
"While motor effects of dopaminergic medication and subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients are well explored, their effects on sensory processing are less well understood. Here, we studied the impact of levodopa and STN-DBS on auditory processing.... | This differential treatment effect suggests a divergent mode of action of levodopa and STN-DBS on auditory processing. | yes |
25,097,454 | Does ropivacaine attenuate endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling? | {
"contexts": [
"Acute lung injury (ALI) is associated with high mortality due to the lack of effective therapeutic strategies. Mechanical ventilation itself can cause ventilator-induced lung injury. Pulmonary vascular barrier function, regulated in part by Src kinase-dependent phosphorylation of caveolin-1 and i... | Ropivacaine may be a promising therapeutic agent for treating the cause of pulmonary edema by blocking inflammatory Src signaling, ICAM-1 expression, leukocyte infiltration, and vascular hyperpermeability. | yes |
25,073,444 | Do exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice? | {
"contexts": [
"Exosomes released from cells can transfer both functional proteins and RNAs between cells. In this study we tested the hypothesis that muscle cells might transmit specific signals during lipid-induced insulin resistance through the exosomal route.",
"Exosomes were collected from quadriceps mu... | Exosomes act as 'paracrine-like' signals and modify muscle homeostasis during high-fat diets. | yes |
25,081,699 | Does iL-12 regulate B7-H1 expression in ovarian cancer-associated macrophages by effects on NF-κB signalling? | {
"contexts": [
"B7-H1, a co-inhibitory molecule of the B7 family, is found aberrantly expressed in ovarian cancer cells and infiltrating macrophage/dendritic-like cells, and plays a critical role in immune evasion by ovarian cancer. IL-12, an inducer of Th1 cell development, exerts immunomodulatory effects on ov... | IL-12 upregulates the expression of B7-H1 in monocyte-derived macrophages, which is possible though inducing the secretion of IFN-γ and further activating the NF-κB signal pathway. However, IL-12 downregulates the expression of B7-H1 in THP-1-derived macrophages, associated with a lack of IFN-γ and inhibition of expres... | yes |
25,100,235 | Does vitamin A-enriched diet modulate reverse cholesterol transport in hypercholesterolemic obese rats of the WNIN/Ob strain? | {
"contexts": [
"Vitamin A plays a major role in lipid metabolism. Previously, we reported that chronic vitamin A feeding (129 mg/kg) for two months normalized the abnormally high plasma HDL-cholesterol (HDL-C) levels in hypercholesterolemic obese rats by upregulating the hepatic scavenger receptor class B type 1... | Chronic feeding of a vitamin A-enriched diet in hypercholesterolemic obese rats normalizes the plasma HDL-C level and presumably improves RCT, with an effective dose of 52 mg/kg diet. Further studies should focus on the pharmacological potential of vitamin A supplementation to correct an abnormal human obesity-associat... | yes |
25,080,773 | Do pre-admission clinical factors affect length of stay in the epilepsy monitoring unit? | {
"contexts": [
"Video-EEG monitoring in the epilepsy monitoring unit (EMU) is a limited clinical resource. Knowledge of the predicting factors for length of stay (LOS) in the EMU may allow providers to more efficiently utilize EMU bed space.",
"The records for all consecutive admissions to the EMU at the Uni... | Pre-admission clinical variables may predict EMU LOS. These factors could be used at the administrative level for maximum EMU resource utilization. | yes |
25,080,170 | Does transcriptional profiling of Arabidopsis root hairs and pollen define an apical cell growth signature? | {
"contexts": [
"Current views on the control of cell development are anchored on the notion that phenotypes are defined by networks of transcriptional activity. The large amounts of information brought about by transcriptomics should allow the definition of these networks through the analysis of cell-specific tr... | Our results suggest that maintaining apical growth mechanisms synchronized with energy yielding might require a combinatorial network of transcriptional regulation. We propose that this study should constitute the foundation for further genetic and physiological dissection of the mechanisms underlying apical growth of ... | yes |
25,093,413 | Are complaints of sleep disturbances associated with cardiovascular disease : results from the Gutenberg Health Study? | {
"contexts": [
"Despite their high prevalence, sleep disorders often remain unrecognized and untreated because of barriers to assessment and management. The aims of the present study were to examine associations of complaints of sleep disturbances with cardiovascular disease, related risk factors, and inflammati... | Given the high prevalence of complaints of sleep disturbances and their strong impact on health status, increased efforts should be undertaken for their identification and treatment. | yes |
25,077,441 | Does hLA and KIR genotyping correlate with relapse after T-cell-replete haploidentical transplantation in chronic myeloid leukaemia patients? | {
"contexts": [
"Conflicting results have been reported regarding the predicative roles of alloreactive natural killer (NK) cells on the outcomes of transplantation in leukaemia patients.",
"We prospectively analysed the human leukocyte antigen (HLA) typing of donor-recipient pairs and the KIR typing of the d... | This study suggests that the presence of class I ligands for the donor-activating or donor-inhibitory KIR gene in the recipient might confer some protection against leukaemic relapse in T-cell-replete haploidentical transplantation. | yes |
25,077,442 | Does dasatinib worsen the effect of cetuximab in combination with fractionated radiotherapy in FaDu- and A431-derived xenografted tumours? | {
"contexts": [
"Cetuximab is often combined with radiotherapy in advanced SCCHN. Alternative routes bypassing inhibition of EGFR with cetuximab may overshadow the efficacy of this combination. We undertook this study to investigate a possible role of dasatinib in this scenario.",
"The SCC5, SCC25, SCC29, FaD... | In xenografts derived from these two cell lines, dasatinib did not improve the efficacy of cetuximab combined with radiotherapy. On the contrary, it worsened tumour control achieved by the combination of these two treatments. | yes |
25,073,934 | Does serum glycated albumin predict the progression of diabetic retinopathy -- a five year retrospective longitudinal study? | {
"contexts": [
"To assess the predictive value of glycated albumin (GA) and other risk factors on a progression of diabetic retinopathy (DR).",
"In this retrospective longitudinal study, we enrolled the subjects with type 2 diabetes who had undergone fundus photography twice with a 5-years gap between Januar... | The presence of DR at baseline, poor glycemic control, glycated albumin, and impaired renal function predicted DR progression in patients with type 2 diabetes. | yes |
25,090,165 | Is dexamethasone diffusion across contact lenses inhibited by Staphylococcus epidermidis biofilms in vitro? | {
"contexts": [
"This study was designed to measure the impact of bacterial biofilms on diffusion of an ocular therapeutic through silicone hydrogel bandage lenses in vitro.",
"An assay was designed to study the passage of a commonly used steroid, dexamethasone, through silicone hydrogel soft contact lenses. ... | The results of this in vitro study demonstrate that bacterial biofilms impede dexamethasone diffusion through silicone hydrogel contact lenses and warrant future studies regarding the clinical benefit of using ocular therapeutics in the setting of bandage contact lens use for corneal epithelial defects. | yes |
25,092,915 | Does metastasis-associated protein ribosomal RNA processing 1 homolog B ( RRP1B ) modulate metastasis through regulation of histone methylation? | {
"contexts": [
"Overexpression of ribosomal RNA processing 1 homolog B (RRP1B) induces a transcriptional profile that accurately predicts patient outcome in breast cancer. However, the mechanism by which RRP1B modulates transcription is unclear. Here, the chromatin-binding properties of RRP1B were examined to de... | RRP1B, a breast cancer metastasis suppressor, regulates gene expression through heterochromatinization and transcriptional repression, which helps our understanding of mechanisms that drive prognostic gene expression in human breast cancer. | yes |
25,099,007 | Does enhancing the detection of barcoded read in high throughput DNA sequencing data by controlling the false discovery rate? | {
"contexts": [
"DNA barcodes are short unique sequences used to label DNA or RNA-derived samples in multiplexed deep sequencing experiments. During the demultiplexing step, barcodes must be detected and their position identified. In some cases (e.g., with PacBio SMRT), the position of the barcode and DNA context... | Our method offers a proper quantitative treatment of the problem of detecting barcoded reads in a noisy sequencing environment. It is based on the false discovery rate statistics that allows a proper trade-off between sensitivity and precision to be chosen. | yes |
25,093,847 | Does hydrogen peroxide elicit constriction of skeletal muscle arterioles by activating the arachidonic acid pathway? | {
"contexts": [
"The molecular mechanisms of the vasoconstrictor responses evoked by hydrogen peroxide (H2O2) have not been clearly elucidated in skeletal muscle arterioles.",
"Changes in diameter of isolated, cannulated and pressurized gracilis muscle arterioles (GAs) of Wistar-Kyoto rats were determined und... | These data suggest that H2O2 activates the endothelial Src kinase/PLC/PKC/PLA pathway, ultimately leading to the synthesis and release of TXA2 by COX-1, thereby increasing the Ca(2+) sensitivity of the vascular smooth muscle cells and eliciting constriction in rat skeletal muscle arterioles. | yes |
25,093,845 | Does smoking cessation reverse DNA double-strand breaks in human mononuclear cells? | {
"contexts": [
"Cigarette smoking is a major risk factor for atherosclerotic cardiovascular disease, which is responsible for a significant proportion of smoking-related deaths. However, the precise mechanism whereby smoking induces this pathology has not been fully delineated. Based on observation of DNA double... | Smoking induces DSBs in human MNCs in vivo, and importantly, smoking cessation for 1 month resulted in a decrease in DSBs to a level comparable to that seen in non-smokers. These data reinforce the notion that the cigarette smoking induces DSBs and highlight the importance of smoking cessation. | yes |
25,070,523 | Do aging and alcohol interact to alter hepatic DNA hydroxymethylation? | {
"contexts": [
"Aging and chronic alcohol consumption are both modifiers of DNA methylation, but it is not yet known whether chronic alcohol consumption also alters DNA hydroxymethylation, a newly discovered epigenetic mark produced by oxidation of methylcytosine. Furthermore, it has not been tested whether agin... | The observation that alcohol alters DNA hydroxymethylation indicates a new epigenetic effect of alcohol. This is the first study demonstrating the interactive effects of chronic alcohol consumption and aging on DNA hydroxymethylation. | yes |
25,081,746 | Is chronic cerebrospinal venous insufficiency associated with chronic venous disorders : A case-control study? | {
"contexts": [
"To evaluate the relationship between chronic cerebrospinal venous insufficiency (CCSVI) and the presence of a Chronic Venous Disorder (CVD).",
"We included 55 subjects with CCSVI aged >18 years, and 186 controls without CCSVI. Each subject was evaluated with color Doppler sonography in accord... | We found no association of CCSVI with the presence of CVD or family history of varicose veins. | no |
25,073,540 | Does cigarette smoke condensate inhibit collagen gel contraction and prostaglandin E2 production in human gingival fibroblasts? | {
"contexts": [
"Granulation tissue remodeling and myofibroblastic differentiation are critically important events during wound healing. Tobacco smoking has a detrimental effect in gingival tissue repair. However, studies evaluating the effects of cigarette smoke on these events are lacking.",
"We used gingiv... | CSC may alter the capacity of gingival fibroblasts to remodel and contract a collagen matrix. Inhibition of PGE(2) production and alterations of actin stress fibers in these cells may impair proper tissue maturation during wound healing in smokers. | yes |
25,073,543 | Does meta-analysis show that infants who have suffered neonatal sepsis face an increased risk of mortality and severe complications? | {
"contexts": [
"Infants suffering from neonatal sepsis face an increased risk of early death and long-term neurodevelopmental delay. This paper analyses and summarises the existing data on short-term and long-term outcomes of neonatal sepsis, based on 12 studies published between January 2000 and 1 April 2012 an... | Infants who have suffered neonatal sepsis face an increased risk of mortality and severe complications such as brain damage and, or, neurodevelopmental delay. | yes |
25,083,083 | Does mast cell deficiency exacerbate inflammatory bowel symptoms in interleukin-10-deficient mice? | {
"contexts": [
"To test the role of mast cells in gut inflammation and colitis using interleukin (IL)-10-deficient mice as an experimental model.",
"Mast cell-deficient (Kit (W-sh/W-sh) ) mice were crossbred with IL-10-deficient mice to obtain double knockout (DKO) mice. The growth, mucosal damage and coliti... | Mast cell deficiency in IL-10-deficient mice resulted in systematic and gut inflammation, impaired gut barrier function, and severer Th1-mediated colitis when compared to mice with only IL-10-deficiency. Inflammation and impaired gut epithelial barrier function likely form a vicious cycle to worsen colitis in the DKO m... | yes |
25,100,123 | Does stathmin destabilizing microtubule dynamics promote malignant potential in cancer cells by epithelial-mesenchymal transition? | {
"contexts": [
"Stathmin is a ubiquitous cytosolic regulatory phosphoprotein and is overexpressed in different human malignancies. The main physiological function of stathmin is to interfere with microtubule dynamics by promoting depolymerization of microtubules or by preventing polymerization of tubulin heterod... | We propose that there is a stathmin-microtubule dynamics-EMT (S-M-E) axis during cancer development. By this axis, stathmin together with its microtubule-destabilizing activity contributes to EMT, which stimulates the malignant potential in cancer cells. | yes |
25,090,481 | Is baseline diabetic knowledge after 5-day teaching program an independent predictor of subclinical macroangiopathy in patients with type 1 diabetes ( Poznan Prospective Study )? | {
"contexts": [
"The cardiovascular diseases (CVD) are the leading cause of mortality in type 1 diabetes (DM1). Carotid intima-media thickness (IMT) has been approved as a marker of subclinical atherosclerosis. The aim of this prospective study was to evaluate the relationship between baseline diabetic knowledge ... | Baseline diabetic knowledge after 5-day teaching program is an independent predictor of subclinical macroangiopathy in patients with DM1. | yes |
25,069,706 | Is a trabecular plate-like phenotype overrepresented in Chinese-American versus Caucasian women? | {
"contexts": [
"This study used extreme phenotype selection to define two trabecular bone phenotypes in a cohort of Chinese-American and Caucasian women. A trabecular plate-predominant phenotype is more common in Chinese-Americans while the rod-predominant phenotype is more typical of Caucasians. The robustness ... | Using extreme phenotype selection, we defined a plate- and rod-like trabecular bone phenotype for the TPR ratio trait. The former phenotype is more common in Chinese-American women, while the latter is more typical of Caucasian women. The robustness of these phenotypic associations after controlling for differences in ... | yes |
25,082,369 | Do cadmium-induced ethylene production and responses in Arabidopsis thaliana rely on ACS2 and ACS6 gene expression? | {
"contexts": [
"Anthropogenic activities cause metal pollution worldwide. Plants can absorb and accumulate these metals through their root system, inducing stress as a result of excess metal concentrations inside the plant. Ethylene is a regulator of multiple plant processes, and is affected by many biotic and a... | Cadmium induced the biosynthesis of ACC and ethylene in Arabidopsis thaliana plants mainly via the increased expression of ACS2 and ACS6. This was confirmed in the acs2-1acs6-1 double knockout mutants, which showed a decreased ethylene production, positively affecting leaf biomass and resulting in a delayed induction o... | yes |
25,076,170 | Does environmental enrichment restore cognitive deficits induced by experimental childhood meningitis? | {
"contexts": [
"To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy.",
"On postnatal day 11, the animals received either artificial cerebrospin... | The data presented suggest that EE, a non-invasive therapy, enables recovery from memory deficits caused by neonatal meningitis. | yes |
25,081,339 | Does proper timing of adjuvant chemotherapy affect survival in patients with stage 2 and 3 gastric cancer? | {
"contexts": [
"Adjuvant chemotherapy improves survival in patients with gastric cancer. However, the relationship between the timing of adjuvant chemotherapy and survival has not been investigated.",
"Patients with D2-resected stage 2 and 3 gastric cancer that received adjuvant chemotherapy from 2005 to 201... | There is insufficient evidence to suggest starting adjuvant chemotherapy within 4 weeks after surgery for patients with D2 resected stage 2 and 3 gastric cancer. However, delayed treatment of adjuvant chemotherapy after 8 weeks showed worse survival outcomes than early and intermediate treatment initiation, suggesting ... | yes |
25,082,544 | Does dexmedetomidine inhibit inducible nitric oxide synthase in lipopolysaccharide-stimulated microglia by suppression of extracellular signal-regulated kinase? | {
"contexts": [
"Dexmedetomidine (DEX) has been implicated in modulating the inflammatory response in central nervous system (CNS). However, the mechanism is still poorly understood. In this study, we evaluate the effects of DEX on lipopolysaccharide (LPS)-induced microglia activation and elucidate its possible s... | Dexmedetomidine attenuates NO and iNOS accumulation by inhibiting extracellular signal-regulated kinase (ERK) activation in both BV2 cells and primary microglial cells. | yes |
25,083,983 | Does lung-targeted RNA interference against angiopoietin-2 ameliorate multiple organ dysfunction and death in sepsis? | {
"contexts": [
"Angiopoietin-2, a protein secreted by stimulated endothelium and an antagonist of the endothelium-stabilizing receptor Tie2, contributes to the pathophysiology of septic multiple organ dysfunction. We tested the therapeutic potential of a pulmonary-endothelium-specific RNA interference-based angi... | The Tie2 antagonist angiopoietin-2 represents a promising target against sepsis-associated multiple organ dysfunction. A novel RNA interference therapeutic approach targeting gene expression in the pulmonary endothelium could be a clinically relevant pharmacological strategy to reduce injurious angiopoietin-2 synthesis... | yes |
25,092,376 | Does a Rb1 promoter variant with reduced activity contribute to osteosarcoma susceptibility in irradiated mice? | {
"contexts": [
"Syndromic forms of osteosarcoma (OS) account for less than 10% of all recorded cases of this malignancy. An individual OS predisposition is also possible by the inheritance of low penetrance alleles of tumor susceptibility genes, usually without evidence of a syndromic condition. Genetic variants... | This is the first experimental demonstration of a functional and genetic link between reduced Rb1 expression from a common promoter variant and increased tumor risk after radiation exposure. We propose that a reduced Rb1 expression by common variants in regulatory regions can modify the risk for a malignant transformat... | yes |
25,069,458 | Does androgen receptor expression in male breast cancer predict inferior outcome and poor response to tamoxifen treatment? | {
"contexts": [
"Androgen receptor (AR) plays an important role in male breast cancer (MBC). Additionally, endocrine therapy is the most important treatment in oestrogen receptor (ER)-positive advanced breast cancer. This study was aimed to investigate the role of AR in MBC treatment and prognosis and to analyse ... | AR expression correlates strongly with both OS and DFS in patients with MBC. AR-positive patients can predict a poorer clinical outcome than AR-negative patients after adjuvant tamoxifen therapy. | yes |
25,091,364 | Does nerve ultrasound depict peripheral nerve enlargement in patients with genetically distinct Charcot-Marie-Tooth disease? | {
"contexts": [
"To elucidate the ultrasound (US) features of peripheral nerves including nerve roots in patients with different types of Charcot-Marie-Tooth disease (CMT), and the association between US findings, clinical features and parameters of nerve conduction studies (NCS) in CMT1A.",
"US of median, su... | Nerve US may aid in differentiating among the subtypes of CMT in combination with NCS. In CMT1A, the median nerve CSA correlates with the disease severity and peripheral nerve function. | yes |
25,085,524 | Does δNp63α enhance the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2? | {
"contexts": [
"ΔNp63, a splice variant of p63, is overexpressed and exhibits oncogenic activity in many cancers including pancreatic and breast cancer and promotes cell survival by inhibiting apoptosis. Despite its role in tumorigenesis, mechanistic activity of ΔNp63 mediated oncogenic function in osteosarcoma ... | Here, we report that GLI2 is the novel target gene of ΔNp63α and that ΔNp63α-GLI2 crosstalk in osteosarcoma cells is a necessary event in osteosarcoma progression. Defining the exact mechanisms involved in this interaction that mediate the pathogenesis of osteosarcoma promises to identify targets for drug therapy. | yes |
25,075,223 | Is single cell segmental aneuploidy detection compromised by S phase? | {
"contexts": [
"Carriers of balanced translocations are at high risk for unbalanced gametes which can result in recurrent miscarriages or birth defects. Preimplantation genetic diagnosis (PGD) is often offered to select balanced embryos. This selection is currently mainly performed by array CGH on blastomeres. C... | The results demonstrate that the accuracy to detect segmental chromosomal imbalances is reduced in S-phase cells, which could be a source of misdiagnosis in PGD. Hence, the cell cycle phase of the analyzed cell is of great importance and should be taken into account during the analysis. This knowledge may guide future ... | yes |
25,072,612 | Is pPARγ2 Pro12Ala polymorphism associated with sustained virological response in HIV/HCV-coinfected patients under HCV therapy? | {
"contexts": [
"To analyze whether peroxisome proliferator-activated receptor gamma (PPARγ2) rs1801282 (Pro12Ala) polymorphism is associated with the response to pegylated-interferon-alpha plus ribavirin treatment in HIV/hepatitis C virus (HCV)-coinfected patients, and whether it is able to predict the outcome o... | The presence of PPARγ2 rs1801282 G allele (Ala variant) was associated with increased odds for achieving SVR in HIV/HCV-coinfected patients on HCV treatment. | yes |
25,072,223 | Does cyclosporine-inhibitable cerebral drug transport influence clinical methadone pharmacodynamics? | {
"contexts": [
"Interindividual variability and drug interaction studies suggest that blood-brain barrier drug transporters mediate human methadone brain biodistribution. In vitro and animal studies suggest that methadone is a substrate for the efflux transporter P-glycoprotein, and that P-glycoprotein-mediated ... | Cyclosporine did not affect methadone pharmacodynamics. This result does not support a role for cyclosporine-inhibitable transporters mediating methadone brain access and biodistribution. | no |
25,098,850 | Do surgeons often underestimate the amount of blood loss in replacement surgeries? | {
"contexts": [
"To assess the accuracy of the clinically estimated blood loss (EBL) when compared with the actual blood loss (ABL) in replacement surgeries.",
"This prospective study was done in Sri Ramachandra Medical Centre from April 2011 to April 2013. Altogether 140 patients undergoing total hip replace... | This study has shown that using clinical estimation alone to guide blood transfusion is inadequate. In this study, 70% of patients had their blood loss underestimated, proving that surgeons often underestimate blood loss in replacement surgeries. | yes |
25,078,870 | Does pharmacological modulation of autophagy enhance Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells? | {
"contexts": [
"Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) ... | These results demonstrate that combination treatment with autophagy modulators is an effective strategy to augment the therapeutic activity of NDV/FMW against drug-resistant lung cancers. | yes |
25,073,281 | Do [ Effectiveness of a suture bridge technique for repair of quadriceps tendon rupture in uraemic patients ]? | {
"contexts": [
"To investigate the effectiveness of a suture bridge technique for quadriceps tendon rupture repair in uraemic patients.",
"Between March 2010 and September 2012, 10 uraemic patients (14 sides) with quadriceps tendon rupture were treated with the suture bridge technique. Of them, 8 were male a... | For fewer traumas and early functional exercise after operation, the suture bridge technique benefits functional restoration of knee joint in uraemic patients. Operation chance and age seem to be important factors to the results. Early operation should be considered when quadriceps tendon ruptured. | yes |
25,095,871 | Is ischemic cardiomyopathy associated with coronary plaque progression and higher event rate in patients after cardiac transplantation? | {
"contexts": [
"Cardiac allograft vasculopathy is the leading cause of graft failure and death in heart transplant (HTx) recipients; however, the association between the etiology of heart failure (ischemic cardiomyopathy [ICM] or non-ICM) that led to HTx and progression of cardiac allograft vasculopathy, and adv... | Our study demonstrates that ischemic etiology of cardiomyopathy prior to HTx may be independently associated with plaque progression and higher event rate after HTx. | yes |
25,085,320 | Is smoking a perioperative risk factor and prognostic factor for lung cancer surgery? | {
"contexts": [
"The aim of this study was to investigate the smoking status of lung cancer patients and to confirm the risk of smoking for patients undergoing lung cancer surgery.",
"We conducted a retrospective study of patients undergoing lung cancer surgery. Between May 2004 and March 2013, 716 patients u... | Smokers with lung cancer tended to have advanced lung cancer, impaired pulmonary function, and high morbidity after lung cancer surgery. Although multivariate analysis did not show that smoking was associated with poor outcome, non-smokers had significantly better overall survival, even for patients with stage IA lung ... | yes |
25,080,447 | Does bacterial CagA protein induce degradation of p53 protein in a p14ARF-dependent manner? | {
"contexts": [
"Infection with Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the stomach. Tumorigenic transformation of gastric epithelium induced by H. pylori is a highly complex process driven by an active interplay between bacterial virulence and host factors, many aspects of wh... | Our results provide novel evidence that tumorigenicity associated with H. pylori infection is linked to inhibition of p53 protein by CagA. We propose a model in which CagA-induced degradation of p53 protein is determined by a relative level of p14ARF. In cells in which p14ARF levels were decreased due to hypermethylati... | yes |
25,080,448 | Does intestinal epithelial vitamin D receptor deletion lead to defective autophagy in colitis? | {
"contexts": [
"Vitamin D and the vitamin D receptor (VDR) appear to be important immunological regulators of inflammatory bowel diseases (IBD). Defective autophagy has also been implicated in IBD, where interestingly, polymorphisms of genes such as ATG16L1 have been associated with increased risk. Although vita... | Our study demonstrates fundamental relationship between VDR, autophagy and gut microbial assemblage that is essential for maintaining intestinal homeostasis, but also in contributing to the pathophysiology of IBD. These insights can be leveraged to define therapeutic targets for restoring VDR expression and function. | yes |
25,069,864 | Does fatigue correlate with the decrease in parasympathetic sinus modulation induced by a cognitive challenge? | {
"contexts": [
"It is known that enhancement of sympathetic nerve activity based on a decrease in parasympathetic nerve activity is associated with fatigue induced by mental tasks lasting more than 30 min. However, to measure autonomic nerve function and assess fatigue levels in both clinical and industrial sett... | The methods described here are useful for assessing the association between fatigue sensation and autonomic nerve activity using a brief cognitive test in healthy females. | yes |
25,069,635 | Does one size fit all : cardiovascular health disparities as a function of ethnicity in Asian-American women? | {
"contexts": [
"Although few studies have examined cardiovascular disease in Asian-American subgroups separately, limited data in Asian Americans strongly suggest that some subgroups are at increased risk. The present study examined modifiable cardiovascular risk factor profiles as a function of Asian ethnicity.... | Modifiable CVD risk factor profiles significantly differed as a function of ethnicity supporting the premise that Asian-American women cannot be categorized as one group and the traditional "one size fits all" prevention or treatment of CVD risk factors should be re-considered. | no |
25,098,540 | Does cT angiography spot sign in intracerebral hemorrhage predict active bleeding during surgery? | {
"contexts": [
"To determine whether the CT angiography (CTA) spot sign marks bleeding complications during and after surgery for spontaneous intracerebral hemorrhage (ICH).",
"In a 2-center study of consecutive spontaneous ICH patients who underwent CTA followed by surgical hematoma evacuation, 2 experience... | The CTA spot sign is associated with more intraoperative bleeding, more postoperative rebleeding, and larger residual ICH volumes in patients undergoing hematoma evacuation for spontaneous ICH. The spot sign may therefore be useful to select patients for future surgical trials. | yes |
25,085,943 | Does bi-level CPAP improve gas exchange when compared with conventional CPAP for the treatment of neonates recovering from respiratory distress syndrome? | {
"contexts": [
"We hypothesised that short-term application of bi-level nasal continuous positive airway pressure CPAP (SiPAP) compared with conventional nasal CPAP (nCPAP) at the same mean airway pressure in infants with persistent oxygen need recovering from respiratory distress syndrome would improve CO2 remo... | At similar mean airway pressures, SiPAP does not improve CO2 removal, oxygenation or other studied physiological parameters with the exception of mean blood pressure, which was not clinically significant. | no |
25,085,006 | Is high plasma levels of high mobility group box 1 associated with the risk of sepsis in severe blunt chest trauma patients : a prospective cohort study? | {
"contexts": [
"High mobility group box 1 (HMGB1) is a late mediator of systemic inflammation. Extracellular HMGB1 play a central pathogenic role in critical illness. The purpose of the study was to investigate the association between plasma HMGB1 concentrations and the risk of poor outcomes in patients with sev... | Plasma HMGB1 levels were significantly elevated in patients with severe blunt chest trauma. HMGB1 levels were associated with the risk of poor outcome in patients with severe blunt chest trauma. Daily HMGB1 levels measurements is a potential useful tool in the early identification of post-trauma complications. Further ... | yes |
25,085,003 | Does the RNA editing enzyme APOBEC1 induce somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas? | {
"contexts": [
"The AID/APOBECs are deaminases that act on cytosines in a diverse set of pathways and some of them have been linked to the onset of genetic alterations in cancer. Among them, APOBEC1 is the only family member to physiologically target RNA, as the catalytic subunit in the Apolipoprotein B mRNA edi... | Our findings suggest that the ability of APOBEC1 to trigger genetic alterations represents a major layer in its oncogenic potential. Such APOBEC1-induced mutator phenotypes could play a role in the onset of esophageal adenocarcinomas. APOBEC1 could be involved in cancer promotion at the very early stages of carcinogene... | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.