pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
25,087,998 | Does miR-506 suppress proliferation of hepatoma cells through targeting YAP mRNA 3'UTR? | {
"contexts": [
"MiR-506 is a miRNA involved in carcinogenesis of several kinds of cancer. In this study, we explored whether miR-506 played a critical role in hepatocellular carcinoma (HCC).",
"Twenty HCC and adjacent normal liver tissue samples were collected. Human hepatoma cell lines HepG2 and H7402 were ... | MiR-506 suppresses the proliferation of hepatoma cells by targeting YAP mRNA. | yes |
25,087,995 | Does ursolic acid ameliorate autoimmune arthritis via suppression of Th17 and B cell differentiation? | {
"contexts": [
"Ursolic acid (UA) is a pentacyclic triterpenoid found in most plant species, which has been shown anti-inflammatory and anti-oxidative activities. In this study, we examined the effects of UA on collagen-induced arthritis (CIA) in mice, and to identify the mechanisms underlying the effects.",
... | UA treatment significantly ameliorates CIA in mice via suppression of Th17 and differentiation. By targeting pathogenic Th17 cells and autoantibody production, UA may be useful for the treatment of autoimmune arthritis and other Th17-related diseases. | yes |
25,087,996 | Does ezetimibe suppress cholesterol accumulation in lipid-loaded vascular smooth muscle cells in vitro via MAPK signaling? | {
"contexts": [
"To investigate the mechanisms of anti-atherosclerotic action of ezetimibe in rat vascular smooth muscle cells (VSMCs) in vitro.",
"VSMCs of SD rats were cultured in the presence of Chol:MβCD (10 μg/mL) for 72 h, and intracellular lipid droplets and cholesterol levels were evaluated using Oil ... | Ezetimibe suppresses cholesterol accumulation in rat VSMCs in vitro by regulating SREBP-1 and caveolin-1 expression, possibly via the MAPK signaling pathway. | yes |
25,087,997 | Does timosaponin A3 induce hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters? | {
"contexts": [
"To investigate the mechanisms underlying the hepatotoxicity of timosaponin A3 (TA3), a steroidal saponin from Anemarrhena asphodeloides, in rats.",
"Male SD rats were administered TA3 (100 mg·kg(-1)·d(-1), po) for 14 d, and the blood and bile samples were collected after the final administrat... | TA3 triggers liver injury through inducing ROS generation and suppressing the expression of BA transporters. Mangiferin, an active component in Anemarrhena, may protect hepatocytes from TA3-induced hepatotoxicity. | yes |
25,073,010 | Does liver X receptor α ( LXRα/NR1H3 ) regulate differentiation of hepatocyte-like cells via reciprocal regulation of HNF4α? | {
"contexts": [
"Hepatocyte-like cells, differentiated from different stem cell sources, are considered to have a range of possible therapeutic applications, including drug discovery, metabolic disease modelling, and cell transplantation. However, little is known about how stem cells differentiate into mature and... | In this study, we found that NR1H3 accelerates hepatic differentiation through an HNF4α-dependent reciprocal network. This contributes to hepatogenesis and is therapeutically beneficial to liver disease. | yes |
25,072,762 | Is bradycardia during therapeutic hypothermia associated with good neurologic outcome in comatose survivors of out-of-hospital cardiac arrest? | {
"contexts": [
"Comatose patients resuscitated after out-of-hospital cardiac arrest receive therapeutic hypothermia. Bradycardia is frequent during therapeutic hypothermia, but its impact on outcome remains unclear. We explore a possible association between bradycardia during therapeutic hypothermia and neurolog... | Bradycardia during therapeutic hypothermia was associated with good neurologic outcome at hospital discharge. Our data indicate that bradycardia should not be aggressively treated in this period if mean arterial pressure, lactate clearance, and diuresis are maintained at acceptable levels. Studies, both experimental an... | yes |
25,069,797 | Does progression-free survival remain poor over sequential lines of systemic therapy in patients with BRAF-mutated colorectal cancer? | {
"contexts": [
"BRAF mutations occur in 5% to 10% of metastatic colorectal cancers and are biomarkers associated with a poor prognosis. However, the outcomes with standard chemotherapy over sequential lines of therapy in a large cohort of patients with BRAF-mutant tumors have not been described.",
"We search... | PFS is expectedly poor for patients with BRAF-mutated metastatic colorectal cancer. Despite the ascertainment bias present (with testing preferentially performed in patients suitable for clinical trials in refractory disease), these data provide historic controls suitable for future study design and support the idea th... | yes |
25,075,070 | Are biologic factors associated with tumor oxygenation prognostic in patients with stage III esophageal cancer : long-term results? | {
"contexts": [
"Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented.",
"In 64 patients, the impact of tumor cell expression of erythropoietin (EPO) and erythropoietin-receptor (EPO-R) and ten additional fact... | The long-term results confirm that hemoglobin levels during radiotherapy and tumor cell expression of EPO-R are significant prognostic factors in patients with locally advanced esophageal cancer. | yes |
25,079,481 | Is integrin β-8 , but not β-5 or -6 , protein expression increased in livers of children with biliary atresia? | {
"contexts": [
"Our previous work demonstrated altered messenger RNA expression of integrin β-5 and -8, using an in silico analysis of publically available data from patients with biliary atresia (BA); however, we were unable to demonstrate statistically significant differences in protein expression because of s... | Our data show that integrin ανβ8, but not integrin ανβ5 or integrin ανβ6, protein expression is increased in liver specimens of patients with BA. These data support the mounting evidence that transforming growth factor-β (TGF-β) activation is responsible for the fibrosis found in BA. Anti-integrin ανβ8 or more global i... | yes |
25,095,771 | Is the dynamic representation of gravity suspended when the idiotropic vector is misaligned with gravity? | {
"contexts": [
"When people are asked to indicate the vanishing location of a moving target, errors in the direction of motion (representational momentum) and in the direction of gravity (representational gravity) are usually found. These errors possess a temporal course wherein the memory for the location of th... | The dynamic visual representation of gravity is neither purely body-referenced nor world-referenced. It seems to be modulated instead by the relationship between the idiotropic vector and physical gravity. | yes |
25,090,261 | Does maslinic acid activate mitochondria-dependent apoptotic pathway in cardiac carcinoma? | {
"contexts": [
"Cardiac carcinoma is the most common subtype of gastric cancer and its incidence has increased in recent years. The current chemotherapeutic drugs exhibit limited effectiveness and significant side effects in patients. Maslinic acid (MA) exerts an anti-tumor activity on a wide range of cancers an... | Our data demonstrated that natural compound, MA, suppressed the growth of cardiac carcinoma by inducing apoptosis via the p38 MAPK/mitochondria/caspase pathway. MA and its derivatives may be promising anti-tumor agents for cardiac carcinoma treatment in the future. (Supplemental Figures available here.). | yes |
25,090,264 | Does metformin reduce circulating malondialdehyde-modified low-density lipoprotein in type 2 diabetes mellitus? | {
"contexts": [
"Type 2 diabetes is known to be associated with increasing cardiovascular mortality. Malondialdehyde-modified LDL (MDA-LDL) is an oxidized LDL and is increased in patients with diabetes or hypertriglyceridemia. Elevated MDA-LDL has been reported to be a risk factor of atherosclerosis or cardiovasc... | These results suggest that increasing the dose of metformin improves serum MDA-LDL levels in type 2 diabetes mellitus. | yes |
25,069,344 | Do [ Comparative analysis of two surgical techniques for controlling nasal width after Le Fort I osteotomy ]? | {
"contexts": [
"To compare the efficacy of two surgical techniques for controllong nasal width after Le Fort I osteotomy.",
"Fifty-five patients who received the Le Fort I osteotomy have been included in this study. They were randomly divided into 2 groups. The experimental group received extraoral ABS, and ... | The surgical technique of ABS is the most important factor for determining the postoperative alar width. Both techniques have better effect on the Sbal-Sbal width control than the G. lat-G. lat and Al-Al width control. Traditional intraoral ABS can more effectively control the alar width. Both techniques cannot complet... | yes |
25,088,104 | Does automated quantification with BRASS reduce equivocal reporting of DaTSCAN ( 123I-FP-CIT ) SPECT studies? | {
"contexts": [
"¹²³I-FP-CIT (DaTSCAN) SPECT studies of the nigrostriatal pathway are a valuable tool in the diagnosis of movement disorders. However some scans are reported as equivocal with potential adverse consequences. We investigated whether the use of quantification of tracer uptake within the striatum can... | Automated quantification of DaTSCAN studies with BRASS and the use of numerical limits can decrease the number of equivocal reports without affecting report accuracy. | yes |
25,097,850 | Does reference range for induced sputum eosinophil counts in Korean adult population? | {
"contexts": [
"Induced sputum analyses are widely utilized to evaluate airway inflammation in asthmatics. However, the values have not been examined in Korean adults.",
"The purpose of this study is to determine reference ranges for induced sputum eosinophils and their influencing factors in Korean adults."... | Current study was the first attempt to determine the reference ranges of induced sputum eosinophils in Korean adults. The cutoff value for sputum eosinophilia was 3.5%, and was significantly associated with atopy. | yes |
25,099,325 | Is indirect foraminal decompression independent of metabolically active facet arthropathy in extreme lateral interbody fusion? | {
"contexts": [
"Retrospective analysis of prospectively collected, nonrandomized radiographical data.",
"To examine the relationship between the presence of preoperative metabolically active facet arthropathy (FA) and the amount of indirect foraminal decompression gained after extreme lateral interbody fusio... | Significant indirect neural decompression is possible in XLIF, regardless of the presence of metabolically active FA. | yes |
25,092,085 | Does the etiology of pectus carinatum involve overgrowth of costal cartilage and undergrowth of ribs? | {
"contexts": [
"We compared the length of costal cartilage and rib between patients with symmetric pectus carinatum and controls without anterior chest wall protrusion, using a 3-dimensional (3D) computed tomography (CT) to evaluate whether the overgrowth of costal cartilage exists in patients with pectus carina... | In patients with symmetric pectus carinatum, the lengths of costal cartilage were longer but the lengths of rib were shorter than those of controls. These findings may supports that the overgrowth of costal cartilage was not the only factor responsible for pectus carinatum. | yes |
25,076,850 | Does lycopene treatment of prostate cancer cell lines inhibit adhesion and migration properties of the cells? | {
"contexts": [
"Consumption of lycopene through tomato products has been suggested to reduce the risk of prostate cancer. Cellular adhesion and migration are important features of cancer progression and therefore a potential target for cancer interception. In the present study we have examined the in vitro effec... | This in vitro investigation indicates that lycopene can influence the cell adhesion and migration properties of cancer cells at a dose which is arguably achievable in patients. The results of our study expand our understanding of a chemo preventive role of lycopene in prostate cancer. | yes |
25,099,342 | Are dact genes chordate specific regulators at the intersection of Wnt and Tgf-β signaling pathways? | {
"contexts": [
"Dacts are multi-domain adaptor proteins. They have been implicated in Wnt and Tgfβ signaling and serve as a nodal point in regulating many cellular activities. Dact genes have so far only been identified in bony vertebrates. Also, the number of Dact genes in a given species, the number and roles ... | The gnathostome Dact gene family comprises four members, derived from a chordate-specific ancestor. The ability to control Wnt signaling seems to be part of the ancestral repertoire of Dact functions, while the ability to inhibit Tgfβ signaling and to carry out specialized, ortholog-specific roles may have evolved late... | yes |
25,076,957 | Are preoperative white matter lesions independent predictors of long-term survival after internal carotid endarterectomy? | {
"contexts": [
"Cerebral white matter lesions (WMLs) predict long-term survival of conservatively treated acute stroke patients with etiology other than carotid stenosis. In carotid endarterectomy patients, WMLs are associated with severe carotid stenosis and unstable plaques, with the risk of perioperative comp... | WMLs in a preoperative CT scan provide a substantially reliable estimate of postoperative long-term survival of carotid endarterectomy patients independent of currently used criteria, i.e. cardiovascular risk factors, indication category and degree of ipsilateral ICA stenosis. | yes |
25,070,816 | Does l-arginine enhance arginine deiminase induced human lymphoma cell growth inhibition through NF-kBp65 and p53 expression in vitro? | {
"contexts": [
"Arginine deiminase (ADI) and L-arginine (L-Arg) can act as anti-tumor agents in-vitro and in-vivo. However, the mechanism of ADI and L-Arg as anti-tumor agents has not been clearly shown.",
"With the goal of understanding the role of ADI and L-Arg in inhibition of cell growth, we used the Ram... | L-arginine enhanced ADI-induced inhibited cell growth through expression of NF-κBp65 and p53 in a dose-dependent manner. | yes |
25,088,500 | Does prolonged erythropoietin treatment impact gene expression in human skeletal muscle? | {
"contexts": [
"We tested for the presence of erythropoietin receptor (Epo-R) in human skeletal muscle and alterations in gene expression after prolonged use of an erythropoiesis-stimulating agent (ESA).",
"Nine healthy men were treated with ESA for 10 weeks (darbepoietin alfa). Muscle biopsies were collecte... | Erythropoietin is unlikely to exert direct effects in human skeletal muscle due to a lack of Epo-R protein. Furthermore, prolonged ESA treatment does not seem to exert either direct or indirect effects on skeletal muscle gene expression. | no |
25,080,433 | Does altered endosome biogenesis in prostate cancer have biomarker potential? | {
"contexts": [
"Prostate cancer is the second most common form of cancer in males, affecting one in eight men by the time they reach the age of 70 years. Current diagnostic tests for prostate cancer have significant problems with both false negatives and false positives, necessitating the search for new molecula... | This discovery of altered endosome biogenesis in prostate cancer may lead to novel biomarkers for more precise cancer detection and patient prognosis. | yes |
25,085,919 | Does whole exome sequencing for familial bicuspid aortic valve identify putative variants? | {
"contexts": [
"Bicuspid aortic valve (BAV) is the most common congenital cardiovascular malformation. Although highly heritable, few causal variants have been identified. The purpose of this study was to identify genetic variants underlying BAV by whole exome sequencing a multiplex BAV kindred.",
"Whole exo... | These results suggest that traditional whole exome sequencing approaches, which assume causal variants alter coding sense, may be insufficient for BAV and other complex traits. Identification of disease-associated variants is facilitated by the use of segregation within families. | yes |
25,092,793 | Are the use of crowdsourcing for dietary self-monitoring : crowdsourced ratings of food pictures comparable to ratings by trained observers? | {
"contexts": [
"Crowdsourcing dietary ratings for food photographs, which uses the input of several users to provide feedback, has potential to assist with dietary self-monitoring.",
"This study assessed how closely crowdsourced ratings of foods and beverages contained in 450 pictures from the Eatery mobile ... | The findings suggest that crowdsourcing holds potential to provide basic feedback on overall diet quality to users utilizing a low burden approach. | yes |
25,097,535 | Does the efficacy of Sustained Natural Apophyseal glide with and without Isometric Exercise Training in Non-specific Neck Pain? | {
"contexts": [
"To determine the efficacy of Sustained Natural Apophyseal Glides (SNAGs) with and without Isometric Exercise Training Program (IETP) in Non-specific Neck Pain (NSNP) Methods: This randomized control trial of one year duration was conducted at out-patient department of Physiotherapy and Rehabilita... | Patients with non-specific neck pain treated with SNAGs manual physical therapy techniques and followed by IETP was more effective in reduction of pain and enhancement of function, as compared to those patients treated with SNAGs manual physical therapy techniques alone. | yes |
25,074,818 | Is normotopic cortex the major contributor to epilepsy in experimental double cortex? | {
"contexts": [
"Subcortical band heterotopia (SBH) is a cortical malformation formed when neocortical neurons prematurely stop their migration in the white matter, forming a heterotopic band below the normotopic cortex, and is generally associated with intractable epilepsy. Although it is clear that the band het... | These results suggest a major role of the normotopic cortex over the band heterotopia in generating interictal epileptiform activity and seizures in brains with SBH. | yes |
25,084,318 | Do self-control and parental control mediate the relationship between negative emotions and emotional eating among adolescents? | {
"contexts": [
"The study was conducted to simultaneously investigate the mediating effects of parental control and adolescents' self-control on the relationship between adolescents' negative emotions and emotional eating, and to determine pathways with the greatest effect among these variables.",
"Negative ... | The results indicate that both self-control and parental control should be considered in designing preventative measures against emotional eating in adolescents. Adolescent self-control training could also assist in preventing emotional eating. | yes |
25,074,991 | Does reference range for serum total and monomeric prolactin for the current generation Abbott Architect assay? | {
"contexts": [
"Exclusion of macroprolactinaemia, a well-recognised interference, as the cause of hyperprolactinaemia is essential to avoid potential misdiagnosis and mismanagement of patients. We have derived gender-specific serum total and post-polyethylene glycol (PEG) precipitation monomeric reference ranges... | The use of post-PEG monomeric reference ranges not only identifies hyperprolactinaemia due solely to macroprolactinaemia but has the added advantage of identifying patients who have simultaneous true monomeric hyperprolactinaemia and elevated concentrations of macroprolactin. | yes |
25,088,758 | Does cognitive dysfunction associated with fall in progressive supranuclear palsy? | {
"contexts": [
"Attentional and executive dysfunctions are associated with falls in community-dwelling elderly individuals and patients with PD. Frontal cognitive dysfunction and falls are frequent symptoms of PSP. We studied to identify the cognitive domains associated with recurrent falls in patients with PSP.... | Recurrent falls in patients with PSP were associated mainly with executive and visuospatial dysfunctions, including (1) impaired coordinated alternating uni- and bimanual motor programming and execution, (2) deficit of attention and decision making in the presence of interference, (3) visuospatial misperception and (4)... | yes |
25,080,153 | Do rheumatologists lack confidence in their knowledge of cannabinoids pertaining to the management of rheumatic complaints? | {
"contexts": [
"Arthritis pain is reported as one of the most common reasons for persons using medical herbal cannabis in North America. \"Severe arthritis\" is the condition justifying legal use of cannabis in over half of all authorizations in Canada, where cannabis remains a controlled substance. As champions... | Rheumatologists lacked confidence in their knowledge of cannabinoid molecules in general and in their competence to prescribe any cannabinoid for rheumatic complaints. In line with this uncertainty, there is reticence to prescribe cannabinoid preparations for rheumatology patients. Guidance is required to inform rheuma... | yes |
25,081,282 | Does glucose-regulated protein 58 modulate β-catenin protein stability in a cervical adenocarcinoma cell line? | {
"contexts": [
"Cervical cancer continues to threaten women's health worldwide, and the incidence of cervical adenocarcinoma (AD) is rising in the developed countries. Previously, we showed that glucose-regulated protein 58 (Grp58) served as an independent factor predictive of poor prognosis of patients with cer... | Our results demonstrate that β-catenin stability is negatively regulated by Grp58 in HeLa cells. Overexpression of Grp58 may be responsible for the loss of or decrease in membranous β-catenin expression in cervical AD. | yes |
25,085,721 | Do age and gender modulate the neural circuitry supporting facial emotion processing in adults with major depressive disorder? | {
"contexts": [
"Emotion processing, supported by frontolimbic circuitry known to be sensitive to the effects of aging, is a relatively understudied cognitive-emotional domain in geriatric depression. Some evidence suggests that the neurophysiological disruption observed in emotion processing among adults with ma... | This the first study to report gender- and age-specific differences in emotion processing circuitry in MDD. Gender-differential mechanisms may underlie cognitive-emotional disruption in older adults with MDD. The present findings have implications for improved probes into the heterogeneity of the MDD syndrome. | yes |
25,086,401 | Is knee arthroscopic surgery beneficial to middle-aged patients with meniscal symptoms : a prospective , randomised , single-blinded study? | {
"contexts": [
"There is no evidence that a knee arthroscopy is more beneficial to middle-aged patients with meniscal symptoms compared to other treatments. This randomised controlled trial aimed to determine whether an arthroscopic intervention combined with a structured exercise programme would provide more be... | Middle-aged patients with meniscal symptoms may benefit from arthroscopic surgery in addition to a structured exercise programme. Patients' age or symptom history (i.e., mechanical symptoms or acute onset of symptoms) didn't affect the outcome. | yes |
25,086,402 | Does meniscal transection rather than excision increase pain behavior and structural damage in experimental osteoarthritis in mice? | {
"contexts": [
"To evaluate pain behavior and structural damage in mice subjected to either meniscal transection or removal.",
"Mice (10/group) were subjected to transection of the medial collateral and anterior cruciate ligaments (ACLT/MCLT) followed by either transection (meniscotomy) or removal (meniscect... | Meniscal transection rather than resection promotes more severe pain and structural damage in mice. Administration of opioids, cyclooxygenase and nitric oxide (NO) synthase inhibitors provide analgesia in this model. Careful description of the structures damaged is crucial when reporting experimental osteoarthritis (OA... | yes |
25,070,294 | Is bRAF mutation status an independent prognostic factor for resected stage IIIB and IIIC melanoma : implications for melanoma staging and adjuvant therapy? | {
"contexts": [
"5-year survival for melanoma metastasis to regional lymph nodes (American Joint Committee on Cancer stage III) is <50%. Knowledge of outcomes following therapeutic lymphadenectomy for stage III melanoma related to BRAF status may guide adjuvant use of BRAF/MEK inhibitors along with established an... | Patients with BRAF mutations experienced rapid progression of metastatic disease with locoregional recurrence rarely seen in isolation, supporting incorporation of BRAF status into melanoma staging and use of BRAF/MEK inhibitors post-TLND. | yes |
25,075,023 | Do histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations? | {
"contexts": [
"Testicular germ cell tumours are the most common malignancies in young males. Molecular biology studies of these tumours are often contradictory. Two histological groups, seminoma and non-seminoma, differ both morphologically and in malignant behaviour. Although a common cytogenetic feature is se... | Occurrence of genetic alterations correlates with clinical behaviour of these tumours and may indicate that such alterations could occur early in the development of seminomas and non-seminomas. | yes |
25,075,026 | Does sOX18 expression predict response to platinum-based chemotherapy in ovarian cancer? | {
"contexts": [
"SOX18 is a transcription factor known to be involved in blood and lymphatic vessel, hair follicle development, and wound healing processes. In addition, it has been reported that SOX18 may influence cancer growth. The role of SOX18 expression in ovarian cancer (OC) has not been determined.",
... | SOX18 may be a new predictive marker for OC. | yes |
25,076,250 | Does upregulation of ID2 antagonize arsenic trioxide-induced antitumor effects in cancer cells? | {
"contexts": [
"Arsenic trioxide (ATO) strongly induces apoptosis and differentiation in acute promyelocytic leukemia, and induces cell cycle arrest in most solid tumors. Although many signaling pathways are involved in its antitumor mechanism, a detailed investigation of the transforming growth factor beta-bone... | A combination of ATO and ID2-targeted agents may have considerable therapeutic benefits in cancers. | yes |
25,074,684 | Does optix define a neuroepithelial compartment in the optic lobe of the Drosophila brain? | {
"contexts": [
"During early brain development, the organisation of neural progenitors into a neuroepithelial sheet maintains tissue integrity during growth. Neuroepithelial cohesion and patterning is essential for orderly proliferation and neural fate specification. Neuroepithelia are regionalised by the expres... | We propose that the optic lobe is compartmentalised by expression of Optix and Vsx1. Our findings provide insight into the spatial patterning of a complex region of the brain, and suggest an evolutionarily conserved principle of visual system development. | yes |
25,072,206 | Does directly sampling the lung of a young child with cystic fibrosis reveal diverse microbiota? | {
"contexts": [
"The airways of people with cystic fibrosis (CF) are chronically infected with a variety of bacterial species. Although routine culture methods are usually used to diagnose these infections, culture-independent, DNA-based methods have identified many bacterial species in CF respiratory secretions ... | These results support the concept that diverse and spatially heterogeneous microbiota, not necessarily dominated by "traditional CF pathogens," are present in the airways of young, symptomatic children with early CF lung disease. | yes |
25,087,193 | Is high self-perceived exercise exertion before bedtime associated with greater objectively assessed sleep efficiency? | {
"contexts": [
"To assess the association between self-perceived exercise exertion before bedtime and objectively measured sleep.",
"Fifty-two regularly exercising young adults (mean age, 19.70 years; 54% females) underwent sleep electroencephalographic recordings 1.5 h after completing moderate to vigorous ... | Against expectations and general recommendations for sleep hygiene, high self-perceived exercise exertion before bedtime was associated with better sleep patterns in a sample of healthy young adults. Further studies should also focus on elderly adults and adults suffering from insomnia. | yes |
25,080,211 | Do single-base-resolution methylomes of Populus trichocarpa reveal the association between DNA methylation and drought stress? | {
"contexts": [
"DNA methylation is an important biological form of epigenetic modification, playing key roles in plant development and environmental responses.",
"In this study, we examined single-base resolution methylomes of Populus under control and drought stress conditions using high-throughput bisulfit... | These findings may provide valuable new insight into our understanding of the interaction between gene expression and methylation of drought responses in Populus. | yes |
25,084,196 | Is s137 phosphorylation of profilin 1 an important signaling event in breast cancer progression? | {
"contexts": [
"Profilins are actin-modulating proteins regulating many intracellular functions based on their multiple and diverse ligand interactions. They have been implicated to play a role in many pathological conditions such as allergies, cardiovascular diseases, muscular atrophy, diabetes, dementia and ca... | Previous studies show that profilin could be executing a dual role in cancer by either suppressing or promoting tumorigenesis in a context dependent manner. In this study we demonstrate for the first time that phosphorylation of profilin 1 at serine 137 enhances oncogenic properties in breast cancer cells. Inhibitors t... | yes |
25,084,021 | Is eZH2 associated with malignant behavior in pancreatic IPMN via p27Kip1 downregulation? | {
"contexts": [
"The epigenetic mechanism of tumorigenesis in pancreatic intraductal papillary mucinous neoplasm (IPMN) remains largely unknown. The aim of this study is to examine the role of enhancer of zeste homologue 2 (EZH2) alteration in pancreatic IPMN progression.",
"Fifty-four surgically resected pan... | EZH2 is associated with the accelerated cell proliferation and malignant step in pancreatic IPMN via the downregulation of p27Kip1. | yes |
25,077,978 | Does methotrexate inhibit NF-κB activity via long intergenic ( noncoding ) RNA-p21 induction? | {
"contexts": [
"To determine interrelationships between the expression of long intergenic (noncoding) RNA-p21 (lincRNA-p21), NF-κB activity, and responses to methotrexate (MTX) in rheumatoid arthritis (RA) by analyzing patient blood samples and cell culture models.",
"Expression levels of long noncoding RNA ... | Our findings support a model whereby depressed levels of lincRNA-p21 in RA contribute to increased NF-κB activity. MTX decreases basal levels of NF-κB activity by increasing lincRNA-p21 levels through a DNA PKcs-dependent mechanism. | yes |
25,085,923 | Is infarct characterization and quantification by delayed enhancement cardiac magnetic resonance imaging a powerful independent and incremental predictor of mortality in patients with advanced ischemic cardiomyopathy? | {
"contexts": [
"Infarct heterogeneity has been shown to be independently associated with adverse outcomes in previous smaller studies. However, it is unknown whether infarct characterization is an independent predictor of all-cause mortality in patients with advanced ischemic cardiomyopathy, after adjusting for ... | In advanced ischemic cardiomyopathy, PI% is a powerful independent and incremental predictor of all-cause mortality. Infarct heterogeneity offers substantial further risk stratification when compared with quantification of total myocardial scar % alone even after adjusting for clinical risk factors, end-systolic volume... | yes |
25,074,630 | Does elective change of surgeon during the OR day have an operationally negligible impact on turnover time? | {
"contexts": [
"To compare turnover times for a series of elective cases with surgeons following themselves with turnover times for a series of previously scheduled elective procedures for which the succeeding surgeon differed from the preceding surgeon.",
"Retrospective cohort study.",
"University-affil... | The investigated institution averages 2.5 cases per OR per day. The cumulative additional turnover time (far less than one hour per OR per day) for switching surgeons definitely does not allow the addition of another elective procedure if the difference could be eliminated. A flexible scheduling policy allowing surgeon... | yes |
25,070,024 | Is esophageal carcinoma cell line with high EGFR polysomy responsive to gefitinib? | {
"contexts": [
"It has previously been shown that gefitinib-treated patients with epidermal growth factor receptor (EGFR) gene amplification or high polysomy had a statistically significant improvement in response, time to progression, and survival in non-small cell lung cancer (NSCLC). Only few studies utilizin... | We show for the first time a significant treatment response to the EGFR tyrosine kinase inhibitor gefitinib in esophageal tumor cells with a high polysomy for EGFR, suggesting a future role of anti-EGFR therapy for esophageal adenocarcinoma patients with a high EGFR polysomy. | yes |
25,084,682 | Does patient trust in physician influence colorectal cancer screening in low-income patients? | {
"contexts": [
"Colorectal cancer (CRC) screening is effective but underutilized. Although physician recommendation is an important predictor of screening, considerable variation in CRC screening completion remains.",
"To characterize the influence of patient trust in care providers on CRC screening behavior... | After controlling for traditional factors, trust in PCP remained the only significant driver of CRC screening completion in low-income patients. Interventions to promote CRC screening may be improved by including efforts to enhance patient trust in PCP. | yes |
25,089,378 | Does hyperoxia inhibit nitric oxide treatment effects in alveolar epithelial cells via effects on L-type amino acid transporter-1? | {
"contexts": [
"The aims of this study were to determine hyperoxia effects on S-nitrosothiol (SNO) accumulation and L-type amino acid transporter 1 (LAT1) expression/function in alveolar epithelium and to determine whether hyperoxia impairs exogenous nitric oxide (NO) treatment effects in alveolar epithelium thr... | SNO uptake after NO treatment is dependent on LAT1. Hyperoxia impairs SNO uptake and NO effects during NO exposure and impairs LAT system function and LAT1 expression. Effects on SNO formation and transport must be considered for rational optimization of NO-based therapeutics. | yes |
25,072,851 | Does sIRT2 deficiency modulate macrophage polarization and susceptibility to experimental colitis? | {
"contexts": [
"SIRT2 belongs to a highly conserved family of NAD+-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes. Recently SIRT2 was revealed to play an important role in infl... | These data confirm a protective role for SIRT2 against the development of inflammatory processes, pointing out a potential role for this sirtuin as a suppressor of colitis. In fact, SIRT2 deletion promotes inflammatory responses by increasing NF-κB acetylation and by reducing the M2-associated anti-inflammatory pathway... | yes |
25,091,398 | Is yttrium-90 radioembolization a safe and effective treatment for unresectable hepatocellular carcinoma : a single centre experience of 45 consecutive patients? | {
"contexts": [
"There is controversy regarding the role of yttrium-90 (90Y) radioembolization in the management of advanced, unresectable hepatocellular carcinoma (HCC).",
"Forty-five consecutive patients underwent resin-based 90Y radioembolization for unresectable, HCC between 2006 and 2013 in Sydney, Austr... | Radioembolization with 90Y is a safe and effective treatment for unresectable HCC. | yes |
25,089,931 | Is a functional synonymous coding variant in the IL1RN gene associated with survival in septic shock? | {
"contexts": [
"Death from infection is a highly heritable trait, yet there are few genetic variants with known mechanism influencing survival during septic shock.",
"We hypothesized that a synonymous coding variant in the IL-1 receptor antagonist gene (IL1RN), rs315952, previously associated with reduced ri... | In European ancestry subjects, the IL1RN variant rs315952C is preferentially transcribed and associated with increased evoked plasma IL1RA and with improved survival from septic shock. It may be that genetically determined IL1RA levels influence survival from septic shock. | yes |
25,074,249 | Is plantarflexion moment a contributor to step length after-effect following walking on a split-belt treadmill in individuals with stroke and healthy individuals? | {
"contexts": [
"To assess plantarflexion moment and hip joint moment after-effects following walking on a split-belt treadmill in healthy individuals and individuals post-stroke.",
"Cross-sectional study.",
"Ten healthy individuals (mean age 57.6 years (standard deviation; SD 17.2)) and twenty individual... | Split-belt treadmills could be useful for restoring step length symmetry in individuals post-stroke who present with a longer paretic step length because the use of this type of intervention increases paretic plantarflexion moments. This intervention might be less recommended for individuals post-stroke with a shorter ... | yes |
25,091,495 | Does electroacupuncture mediate extracellular signal-regulated kinase 1/2 pathways in the spinal cord of rats with inflammatory pain? | {
"contexts": [
"Activation of extracellular signal-regulated kinase1/2 (ERK1/2) in dorsal horn of the spinal cord by peripheral inflammation is contributed to inflammatory pain hypersensitivity. Although electroacupuncture (EA) has been widely used to alleviate various kinds of pain, the underlying mechanism of ... | The present study suggests that EA produces analgesic effect by preventing the activation of ERK1/2-COX-2 pathway and ERK1/2-CREB-NK-1 pathway in CFA rats. | yes |
25,091,629 | Do metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness? | {
"contexts": [
"Targeted metabolomic and transcriptomic approaches were used to evaluate the relationship between skeletal muscle metabolite signatures, gene expression profiles and clinical outcomes in response to various exercise training interventions. We hypothesised that changes in mitochondrial metabolic i... | The metabolic signatures of exercise-trained skeletal muscle reflected reprogramming of mitochondrial function and intermediary metabolism and correlated with changes in cardiometabolic fitness. Succinate metabolism and the succinate dehydrogenase complex emerged as a potential regulatory node that intersects with whol... | yes |
25,086,943 | Does the prognosis of pulmonary metastasectomy depend on the location of the primary colorectal cancer? | {
"contexts": [
"Rectal cancer has a higher risk of developing lung metastasis compared with colon cancer. It is unclear whether the prognosis after pulmonary metastasectomy for these distinct tumors is different.",
"Patients who underwent pulmonary metastasectomy for colorectal carcinoma were analyzed for su... | Disease-free survival and site of recurrence after pulmonary metastasectomy for colorectal carcinoma are dependent on the site of the primary tumor. Lung metastases from rectal cancer have a worse disease-free survival compared with colon cancer. This may influence treatment and follow-up strategies. | yes |
25,088,988 | Does duodenal-jejunal bypass improve diabetes and liver steatosis via enhanced glucagon-like peptide-1 elicited by bile acids? | {
"contexts": [
"Bariatric surgery not only elicits weight loss but also rapidly resolves diabetes. However, the mechanisms remain unclear. The present study investigates how diabetes and liver steatosis are improved after duodenal-jejunal bypass (DJB) compared with a glucagon-like peptide-1 (GLP-1) analog and co... | Duodenal-jejunal bypass might improve diabetes and liver steatosis by enhancing GLP-1 secretion through increasing serum bile acids and the proliferation of L cells in the ileum, compared with liraglutide. | yes |
25,088,986 | Are not all intestinal traumatic injuries the same : a comparison of surgically treated blunt vs. penetrating injuries? | {
"contexts": [
"Traumatic intestinal injuries are less common with blunt compared to penetrating mechanisms of trauma and blunt injuries are often associated with diagnostic delays. The purpose of this study is to evaluate differences in the characteristics and outcomes between blunt and penetrating intestinal i... | Blunt and penetrating intestinal injury patterns have high injury severity. Significant operative delays occurred in the blunt injury group as well as, anastomotic failures, enteric fistulas, nosocomial infections, and higher cost. These features underscore the complexity of blunt injury patterns and warrant vigilant i... | yes |
25,075,098 | Does resveratrol induce luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture? | {
"contexts": [
"We have previously reported the crucial roles of oncogenic Kirsten rat sarcoma viral oncogene homolog (KRAS) in inhibiting apoptosis and disrupting cell polarity via the regulation of phosphodiesterase 4 (PDE4) expression in human colorectal cancer HCT116 cells in three-dimensional cultures (3DC)... | Resveratrol induced apoptosis of HCT116 cells in 3DC, resulting in the formation of a luminal cavity, probably by inhibiting PDE4 activity. | yes |
25,095,747 | Is upper extremity access for fenestrated endovascular aortic aneurysm repair associated with increased morbidity? | {
"contexts": [
"Fenestrated endovascular aortic aneurysm repair (FEVAR) is an alternative to open repair in patients with complex abdominal aortic aneurysms who are neither fit nor suitable for standard open or endovascular repair. Chimney and snorkel grafts are other endovascular alternatives but frequently req... | Upper extremity access appears to be a safe and feasible approach for patients undergoing FEVAR. Open exposure in the upper extremity may be safer than percutaneous access during FEVAR. Unlike chimney and snorkel grafts, upper extremity access during FEVAR is not associated with an increased risk of stroke, despite the... | no |
25,079,429 | Is allelic variation within the S-adenosyl-L-homocysteine hydrolase gene family associated with wood properties in Chinese white poplar ( Populus tomentosa )? | {
"contexts": [
"S-adenosyl-l-homocysteine hydrolase (SAHH) is the only eukaryotic enzyme capable of S-adenosyl-l-homocysteine (SAH) catabolism for the maintenance of cellular transmethylation potential. Recently, biochemical and genetic studies in herbaceous species have obtained important discoveries in the fun... | The present study demonstrates that PtoSAHHs were split off prior to the divergence of interspecies in Populus, and SAHHs may play a key role promoting transmethylation reactions in the secondary cell walls biosynthesis in trees. Hence, our findings provide insights into SAHH function and evolution in woody species and... | yes |
25,082,159 | Does post-weaning diet determine metabolic risk in mice exposed to overnutrition in early life? | {
"contexts": [
"Maternal overnutrition during pregnancy is associated with an increased risk of obesity and cardiometabolic disease in the offspring; a phenomenon attributed to 'developmental programming'. The post-weaning development of obesity may associate with exacerbation of the programmed metabolic phenoty... | These results suggest that post-weaning exposure to a high-fat high-sugar diet has a more profound effect on offspring weight gain and glucose tolerance than exposure to maternal overnutrition. These data emphasise the importance of optimising early life nutrition in offspring of both obese and lean mothers. | yes |
25,097,246 | Is activation of dopamine D2 receptor critical for the development of form-deprivation myopia in the C57BL/6 mouse? | {
"contexts": [
"This study used dopamine D2 receptor (D2R) knockout (KO) mice to investigate the role of D2R activity in the development of form-deprivation myopia (FDM). Sulpiride, a D2R antagonist, was administered systemically into wild-type (WT) mice to validate the involvement of D2R in FDM development.",
... | Genetic and pharmacological inactivation of D2R attenuates FDM development in mice, suggesting that dopamine acting on D2R appears to promote the development of FDM in C57BL/6 mice. Further studies are required to confirm these results using animal models in which retinal D2R is selectively blocked. | yes |
25,097,240 | Is retinal ischemia/reperfusion injury mediated by Toll-like receptor 4 activation of NLRP3 inflammasomes? | {
"contexts": [
"Retinal ischemia/reperfusion (IR) is common in eye disorders. Pattern-recognition receptors (PRRs) are reported to initiate sterile inflammatory response. The role of PRRs in retinal IR injury is currently unknown. Thus, we investigated the expression and function of membrane and cytoplasmic PRRs... | These findings suggest that TLR4-signaling activation, triggered by damage-associated molecular patterns, regulates the activation of the NLRP3 inflammasomes and is responsible for the function of the retina in retinal IR injury. | yes |
25,083,606 | Does confocal endomicroscopy show food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome? | {
"contexts": [
"We investigated suspected food intolerances in patients with irritable bowel syndrome (IBS) using confocal laser endomicroscopy (CLE) for real-time visualization of structural/functional changes in the intestinal mucosa after food challenge. Patients with functional changes after food challenge (... | Based on CLE analysis of IBS patients with a suspected food intolerance, exposure to candidate food antigens caused immediate breaks, increased intervillous spaces, and increased IELs in the intestinal mucosa. These changes are associated with patient responses to exclusion diets. Registered at clinicaltrials.gov (regi... | yes |
25,084,128 | Are serum cystatin C levels associated with coronary artery disease and its severity? | {
"contexts": [
"Serum cystatin C has been established as a predictor of cardiovascular events. The aim of this study was to evaluate the role of cystatin C in determining the presence and the severity of patients with coronary artery disease (CAD).",
"A total of 936 subjects without overt renal disease were ... | Elevated serum cystatin C levels were significantly associated with the presence and severity of CAD in patients with normal renal function. It is suggested that cystatin C might play a role in CAD diagnosis and serve as a marker of CAD severity. | yes |
25,080,326 | Are equine mesenchymal stromal cells and embryo-derived stem cells immune privileged in vitro? | {
"contexts": [
"Autologous mesenchymal stem cells (MSCs) are an attractive concept in regenerative medicine, but their mechanism of action remains poorly defined. No immune response is reported after in vivo injection of allogeneic equine MSCs or embryo-derived stem cells (ESCs) into the equine tendon, which may... | Equine MSCs and ESCs possess a degree of innate immune privilege, and MSCs secrete soluble factors that suppress PBMC proliferation and alter cytokine expression. These properties may make possible the future clinical use of allogeneic stem cells to help standardize and broaden the scope of treatment of tissue injuries... | yes |
25,091,343 | Do quantitative EEG markers relate to Alzheimer 's disease severity in the Prospective Dementia Registry Austria ( PRODEM )? | {
"contexts": [
"To investigate which single quantitative electro-encephalographic (QEEG) marker or which combination of markers correlates best with Alzheimer's disease (AD) severity as measured by the Mini-Mental State Examination (MMSE).",
"We compared quantitative EEG markers for slowing (relative band po... | Selected QEEG markers show strong associations with AD severity. Both cognitive and resting state should be used for QEEG assessments. | yes |
25,091,344 | Does wireless EEG with individualized channel layout enable efficient motor imagery training? | {
"contexts": [
"The study compared two channel-reduction approaches in order to investigate the effects of systematic motor imagery (MI) neurofeedback practice in an everyday environment using a very user-friendly EEG system consisting of individualized caps and highly portable hardware.",
"Sixteen BCI novic... | The present study demonstrates that systematic MI practice in an everyday environment with a user-friendly EEG system results in MI learning effects. | yes |
25,069,573 | Does transcriptional profiling of peripheral blood in pancreatic adenocarcinoma patients identify diagnostic biomarkers? | {
"contexts": [
"Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy associated with poor survival rates. Fast detection of PDAC appears to be the most relevant strategy to improve the long-term survival of patients.",
"Our objective was to identify new markers in peripheral blood that differentiat... | Peripheral blood gene expression profiling is an useful tool for the diagnosis of PDAC. We present a validated four-gene predictor set (ANKRD22, CLEC4D, VNN1, and IRAK3) that may be useful in PDAC diagnosis. | yes |
25,069,570 | Does partial meniscus substitution with a polyurethane scaffold improve outcome after an open-wedge high tibial osteotomy? | {
"contexts": [
"The aim of the study was to determine whether medial meniscal substitution with a polyurethane scaffold (Actifit(®)) improves the outcome of medial meniscal-deficient varus knees undergoing open-wedge high tibial osteotomy.",
"Sixty patients with symptomatic varus knees those who underwent op... | Patients with symptomatic varus knees were treated with open-wedge high tibial osteotomies, and a meniscectomy was improved more at short-term follow-up in most of the evaluated functional scores than those patients with concomitant implantation of a medial Actifit(®) implant. However, there was no difference in terms ... | no |
25,069,861 | Is epithelial-to-mesenchymal transition ( EMT ) in intraductal papillary mucinous neoplasm ( IPMN ) associated with high tumor grade and adverse outcomes? | {
"contexts": [
"Epithelial-to-mesenchymal transition (EMT) is generally associated with increased tumor aggressiveness and poor prognosis. We evaluated EMT characteristics in intraductal papillary mucinous neoplasm (IPMN) tumor specimens and their potential role as biomarkers for malignancy, metastasis, and adve... | EMT may play a role in IPMN tumorigenesis and metastasis. EMT molecular deregulations could be utilized as potential novel biomarkers for the identification of high-risk IPMN patients. | yes |
25,099,603 | Does glucocorticoid receptor coordinate transcription factor-dominated regulatory network in macrophages? | {
"contexts": [
"Inflammation triggered by infection or injury is tightly controlled by glucocorticoid hormones which signal via a dedicated transcription factor, the Glucocorticoid Receptor (GR), to regulate hundreds of genes. However, the hierarchy of transcriptional responses to GR activation and the molecular... | Pro- and anti-inflammatory stimuli alter the expression of a vast array of transcription factors and chromatin remodelers. By regulating multiple transcription factors, which propagate the initial hormonal signal, GR acts as a coordinating hub in anti-inflammatory responses. As several KLFs promote the anti-inflammator... | yes |
25,069,574 | Is krüpple-like factor 5 required for proper maintenance of adult intestinal crypt cellular proliferation? | {
"contexts": [
"Krüpple-like factor 5 (KLF5) is a transcription factor that is highly expressed in the proliferative compartment of the intestinal crypt. There, it is thought to regulate epithelial turnover and homeostasis.",
"In this study, we sought to determine the role for Klf5 in the maintenance of cell... | These results indicate that Klf5 is necessary to maintain adult intestinal crypt proliferation and proper cellular differentiation. Rapid replacement of Klf5-mutant crypts with wildtype cells and reduction of stem cell markers suggests further that Klf5 is required for self renewal of intestinal stem cells. | yes |
25,091,710 | Is fOXF1 transcription factor required for formation of embryonic vasculature by regulating VEGF signaling in endothelial cells? | {
"contexts": [
"Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene locus are frequently found in patients with alveolar capillary dysplasia with misalignment of pulmonary veins, a lethal congenital disorder, which is characterized by severe abnormalities in the respiratory, cardiovas... | FOXF1 is required for the formation of embryonic vasculature by regulating endothelial genes critical for vascular development and vascular endothelial growth factor signaling. | yes |
25,080,915 | Does [ Ketamine induce apoptosis of human uroepithelial SV-HUC-1 cells ]? | {
"contexts": [
"To determine the effect of ketamine on the apoptosis of human uroepithelial cells (SVHUC-1) and the pathogenesis of ketamine-associated cystitis.",
"SV-HUC-1 cells were cultured under various concentrations of ketamine and differenttime. Flow cytometry was used to analyze the rate of cell apo... | Ketamine can induce the apoptosis of SV-HUC-1 cells in a dose and time dependent manner. | yes |
25,090,258 | Is prior ischemic stroke associated with worse clinical outcomes in patients undergoing percutaneous coronary intervention? | {
"contexts": [
"Cerebrovascular accidents (CVAs) frequently coexist with coronary artery disease (CAD) and adversely affect prognosis in patients with CAD; however, fewer studies have investigated the role of prior ischemic stroke on the outcomes of percutaneous coronary intervention (PCI). The aim of this study... | This study demonstrates that, in daily clinical practice, PCI can be provided safely and with good results to patients with a prior ischemic stroke (≥ 3 months). | no |
25,100,676 | Does the presence of a below-ground neighbour alter within-plant seed size distribution in Phaseolus vulgaris? | {
"contexts": [
"Considerable variation in seed size commonly exists within plants, and is believed to be favoured under natural selection. This study aims to examine the extent to which seed size distribution depends on the presence of competing neighbour plants.",
"Phaseolus vulgaris plants rooting with or ... | Below-ground neighbour presence affects within-plant seed size distribution in P. vulgaris. This effect appears to be non-resource-mediated, i.e. to be independent of neighbour-induced effects on resource availability. It implies that, based on current environmental cues, plants can make an anticipatory adjustment of t... | yes |
25,072,126 | Does effective blue light photodynamic therapy affect cutaneous langerhans cell number or oxidatively damage DNA? | {
"contexts": [
"Photodynamic therapy (PDT) using aminolevulinic acid (ALA) with blue light or red light is effective for treating actinic keratoses (AKs). However, immunosuppression follows red light PDT, raising the spectre of skin cancer promotion in treated skin.",
"To determine whether broad-area short i... | Customary blue light BASI-ALA-PDT does not affect the LC number or produce oxidative DNA damage, the sequelae of red light PDT responsible for immunosuppression in treated skin. | no |
25,097,592 | Is the long head of the biceps tendon a suitable cell source for tendon tissue regeneration? | {
"contexts": [
"Tendon tissue engineering (TTE) tries to produce tendinous tissue of high quality to replace dysfunctional tissue. One possible application of TTE might be the replacement of ruptured tissue of the rotator cuff. Autologous tenocytes seem to be most suitable as no differentiation in vitro is neces... | The TDC of the LHB seems to be the most suitable cell source. Further research is necessary to find out if the results can be transferred to an in vivo model. The new collagen I scaffold seems to offer an opportunity to combine good biocompatibility and mechanical strength. | yes |
25,074,975 | Are sleep spindles related to schizotypal personality traits and thalamic glutamine/glutamate in healthy subjects? | {
"contexts": [
"Schizophrenia is a severe mental disorder affecting approximately 1% of the worldwide population. Yet, schizophrenia-like experiences (schizotypy) are very common in the healthy population, indicating a continuum between normal mental functioning and the psychosis found in schizophrenic patients.... | The common relationship of sleep spindle density with schizotypy and thalamic Glx levels indicates a neurobiological overlap between nonclinical schizotypy and schizophrenia. Thus, sleep spindle density and magical ideation may reflect the anatomy and efficiency of the thalamo-cortical system that shows pronounced impa... | yes |
25,092,160 | Is extent of microinvasion in ductal carcinoma in situ associated with sentinel lymph node metastases? | {
"contexts": [
"Ductal carcinoma in situ with microinvasion (DCISM) is a rare diagnosis with a good prognosis. Although nodal metastases are uncommon, sentinel lymph node biopsy (SLNB) remains standard care. Volume of disease in invasive breast cancer is associated with SLNB positivity, and, thus we hypothesized... | Even with large numbers, there was no higher risk of nodal involvement with ≥2 foci of microinvasion compared with 1 focus. Number of microinvasive foci and results of SLNB appear to be used in decision making for systemic therapy. Prognosis is excellent. | no |
25,069,759 | Does interferon α-2b gain high sustained response therapy for advanced essential thrombocythemia and polycythemia vera with JAK2V617F positive mutation? | {
"contexts": [
"This open-label, prospective, observational study aimed to evaluate treatment response, efficacy therapy and safety to IFN α-2b for the essential thrombocythemia (ET) and polycythemia vera (PV) with JAK2V617F positive mutation.",
"A total of 123 ET patients received IFNα-2b therapy with JAK2V... | The data confirmed that IFN α-2b benefited the patients with ET or PV, particularly for JAK2V617F(+) mutation. | yes |
25,069,953 | Does evolutionary acquisition of cysteines determine FOXO paralog-specific redox signaling? | {
"contexts": [
"Reduction-oxidation (redox) signaling, the translation of an oxidative intracellular environment into a cellular response, is mediated by the reversible oxidation of specific cysteine thiols. The latter can result in disulfide formation between protein hetero- or homodimers that alter protein fun... | IPO7 and IPO8 control the nuclear import of FOXO3, but not FOXO4, in a redox-sensitive and disulfide-dependent manner. Our findings suggest that evolutionary acquisition of cysteines has contributed to regulatory divergence of FOXO paralogs, and that phylogenetic analysis can aid in the identification of cysteines invo... | yes |
25,075,051 | Is prognostic nutritional index associated with survival after total gastrectomy for patients with gastric cancer? | {
"contexts": [
"To investigate the influence of clinical characteristics including nutritional markers on postoperative survival in patients undergoing total gastrectomy (TG) for gastric cancer (GC).",
"One hundred fifty-four patients were enrolled. Uni- and multivariate analyses using the Cox proportional h... | PNI is associated with postoperative survival of patients undergoing TG for GC and is able to divide such patients into two independent groups before surgery. | yes |
25,093,616 | Does maturation of growth differentiation factor 15 in human placental trophoblast cells depend on the interaction with Matrix Metalloproteinase-26? | {
"contexts": [
"Matrix Metalloproteinase-26 (MMP-26) is the smallest member of matrix metalloproteinase (MMP) family that functions mainly in the extracellular milieu to cleave the extracellular matrix proteins. It is expressed in various cell types of placenta, but its function in placentation has been poorly u... | This is the first report to demonstrate the physiological function of placental MMP-26 in processing GDF15 and subsequently promoting trophoblast cell apoptosis. These findings expand our understanding of the working mechanism of the metalloproteinase in the process of placentation. | yes |
25,085,920 | Does a common polymorphism in extracellular superoxide dismutase affect cardiopulmonary disease risk by altering protein distribution? | {
"contexts": [
"The enzyme extracellular superoxide dismutase (EC-SOD; SOD3) is a major antioxidant defense in lung and vasculature. A nonsynonomous single-nucleotide polymorphism in EC-SOD (rs1799895) leads to an arginine to glycine amino acid substitution at position 213 (R213G) in the heparin-binding domain. ... | We conclude that EC-SOD provides optimal protection when localized to the compartment subjected to extracellular oxidative stress: thus, the redistribution of EC-SOD from the lung and pulmonary circulation to the extracellular fluids is beneficial in alveolar lung disease but detrimental in pulmonary vascular disease. ... | yes |
25,088,127 | Does effects of hand gestures on auditory learning of second-language vowel length contrast? | {
"contexts": [
"Research has shown that hand gestures affect comprehension and production of speech at semantic, syntactic, and pragmatic levels for both native language and second language (L2). This study investigated a relatively less explored question: Do hand gestures influence auditory learning of an L2 at... | The overall effect of hand gesture on learning of segmental phonology is limited. Implications for theories of hand gesture are discussed in terms of the role it plays at different linguistic levels. | yes |
25,078,331 | Does next-generation sequencing of adrenocortical carcinoma reveal new routes to targeted therapies? | {
"contexts": [
"Adrenocortical carcinoma (ACC) carries a poor prognosis and current systemic cytotoxic therapies result in only modest improvement in overall survival. In this retrospective study, we performed a comprehensive genomic profiling of 29 consecutive ACC samples to identify potential targets of therap... | Next-generation sequencing can discover targets of therapy for relapsed and metastatic ACC and shows promise to improve outcomes for this aggressive form of cancer. | yes |
25,086,377 | Does upregulation of caveolin-1 contribute to aggravated high-salt diet-induced endothelial dysfunction and hypertension in type 1 diabetic rats? | {
"contexts": [
"Endothelial dysfunction and hypertension is more common in individuals with diabetes than in the general population. This study was aimed to investigate the underlying mechanisms responsible for endothelial dysfunction of type 1 diabetic rats fed with high-salt diet.",
"Type 1 diabetes (DM) w... | Impaired endothelial Akt activation and increased cav-1 expression and resultant decreased eNOS activation contributes to aggravated high-salt diet-induced endothelial dysfunction and hypertension in DM rats. | yes |
25,085,021 | Does tLR4 activation induce IL-1β release via an IPAF dependent but caspase 1/11/8 independent pathway in the lung? | {
"contexts": [
"The IL-1 family of cytokines is known to play an important role in inflammation therefore understanding the mechanism by which they are produced is paramount. Despite the recent plethora of publications dedicated to the study of these cytokines, the mechanism by which they are produced in the air... | TLR4 activation increases levels of BALF IL-1b/IL-18 via an IPAF dependent and caspase 1/11/8 independent pathway. Furthermore, it would appear that the presence of IL-1a in the BALF is independent of these pathways. This novel data sheds light on innate signalling pathways in the lung that control the production of th... | yes |
25,086,705 | Do extremely cold and hot temperatures increase the risk of diabetes mortality in metropolitan areas of two Chinese cities? | {
"contexts": [
"Numerous studies have reported the association between ambient temperature and mortality. However, few studies have focused on the effects of extreme temperatures on diabetes mortality, particularly in China. The objective of the present study was to assess the effects of extremely cold and hot t... | The results indicate that both extremely cold and hot temperatures increase diabetes mortality in different manners in Harbin and Chongqing. Diabetes education programs should include information on either managing or combating the effects of extreme hot and cold weather. | yes |
25,099,519 | Does tumor-α9β1 integrin-mediated signaling induce breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts? | {
"contexts": [
"Tumor-derived matricellular proteins such as osteopontin (OPN) and tenascin-C (TN-C) have been implicated in tumor growth and metastasis. However, the molecular basis of how these proteins contribute to tumor progression remains to be elucidated. Importantly, these matricellular proteins are know... | Tumor α9β1 integrin promotes lymphatic metastasis through enhancing invasion. Tumor α9β1 integrin promotes tumor growth through CAFs. Tumor α9β1 integrin enhances the recruitment of CAFs into the primary tumor. Tumor cells induce the production of OPN by CAFs in the primary tumor. CAF-derived OPN promotes tumor growth. | yes |
25,070,602 | Are non-targeted transcription factors motifs a systemic component of ChIP-seq datasets? | {
"contexts": [
"The global effort to annotate the non-coding portion of the human genome relies heavily on chromatin immunoprecipitation data generated with high-throughput DNA sequencing (ChIP-seq). ChIP-seq is generally successful in detailing the segments of the genome bound by the immunoprecipitated transcri... | Based on the zinger regions proximity to cohesin-bound segments, a loading station model is proposed. Further study of zingers will advance understanding of gene regulation. | yes |
25,082,427 | Does complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupt brain development and motor function? | {
"contexts": [
"Infants born preterm commonly suffer from a combination of hypoxia-ischemia (HI) and infectious perinatal inflammatory insults that lead to cerebral palsy, cognitive delay, behavioral issues and epilepsy. Using a novel rat model of combined late gestation HI and lipopolysaccharide (LPS)-induced i... | Prenatal TSHI and TSHI + LPS lead to different patterns of injury with respect to myelination, axon integrity and gait deficits. Dual injury leads to acute alterations in glial response and cellular inflammation, while TSHI alone causes more prominent chronic white matter and axonal injury. Both injuries cause signific... | yes |
25,088,742 | Does p2Y2 nucleotide receptor mediate arteriogenesis in a murine model of hind limb ischemia? | {
"contexts": [
"Arteriogenesis represents the maturation of preformed vascular connections in response to flow changes and shear stress. These collateral vessels can restore up to 60% of the native blood flow. Shear stress and vascular injury can induce the release of nucleotides from vascular smooth muscle cell... | P2Y2R deficiency does not alter baseline collateral vessel formation but does significantly impair collateral maturation, with resultant persistent limb ischemia despite enhanced angiogenesis. These findings reinforce the importance of arteriogenesis in the recovery of perfusion in ischemic tissues compared with angiog... | yes |
25,088,746 | Are decreased plasma levels of select very long chain ceramide species associated with the development of nephropathy in type 1 diabetes? | {
"contexts": [
"Sphingolipid metabolism is altered in diabetes and we analyzed the plasma concentrations of sphingolipid species to investigate their association with the development of albuminuria in type 1 patients with diabetes.",
"Samples were collected from 497 type 1 diabetic patients during their enro... | These studies demonstrate, prospectively, that decreased plasma levels of select ceramide species are associated with the development of macroalbuminuria in type 1 diabetes. | yes |
25,092,157 | Is serum CA 19-9 response to neoadjuvant therapy associated with outcome in pancreatic adenocarcinoma? | {
"contexts": [
"Baseline carbohydrate antigen 19-9 (CA 19-9) is a useful prognostic marker in pancreatic ductal adenocarcinoma (PDA); however, data on the significance of a change in CA 19-9 following neoadjuvant therapy are lacking.",
"All patients receiving neoadjuvant therapy for PDA from July 2010 to Feb... | CA 19-9 response to neoadjuvant therapy is associated with R0 resection rate, histopathologic response, and survival. Incorporation of this easily obtainable biomarker into future clinical trials may facilitate more rapid evaluation of novel regimens. | yes |
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