pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
12,553,678 | Does thalidomide prevent donor corneal graft neovascularization in an alkali burn model of corneal angiogenesis? | {
"contexts": [
"Thalidomide is a potent inhibitor of angiogenesis. We evaluated the effects of Thalidomide on corneal angiogenesis and on tissue survival of grafts in rabbit eyes with pre-existing neovascularization secondary to alkali burn.",
"Sixteen rabbits received alkali burns to one cornea. One month p... | Thalidomide is an effective inhibitor of corneal angiogenesis and prolongs graft survival as measured by graft clarity in donor corneas in eyes with previous neovascularization secondary to alkali injury. | yes |
12,558,193 | Does endogenous adenosine regulate neutrophil pro-inflammatory activities by cyclic AMP-dependent accelerated clearance of cytosolic calcium? | {
"contexts": [
"To identify the involvement of adenosine in restoration of Ca2+ homeostasis to activated human neutrophils.",
"Neutrophils were isolated from venous blood taken from healthy, adult, human volunteers.",
"The cells were exposed to adenosine deaminase (ADA, 0.1-2 units/ml) for 10 min at 37 d... | These results are compatible with a physiological role for adenosine in promoting deactivation of neutrophils, possibly by promoting cAMP-dependent clearance of Ca2+ from the cytosol of the cells by the endo-membrane Ca2+-ATPase. | yes |
12,538,421 | Are beneficial effects of phosphodiesterase 5 inhibition in pulmonary hypertension influenced by natriuretic Peptide activity? | {
"contexts": [
"Phosphodiesterase type 5 (PDE5) inhibitors (eg, sildenafil) are a novel, orally active approach to the treatment of pulmonary arterial hypertension. The role of natriuretic peptides in the response to sildenafil was examined in mice lacking NPR-A, a guanylyl cyclase-linked natriuretic peptide rec... | The natriuretic peptide pathway influences the response to PDE5 inhibition in hypoxia-induced pulmonary hypertension, particularly its effects on RV hypertrophy and vascular remodeling. | yes |
12,552,972 | Do thymidylate synthase and p53 expression in primary tumor predict chemotherapy outcome in metastatic colorectal carcinoma? | {
"contexts": [
"Thymidylate synthase (TS) and p53 expression have been reported to predict the results of palliative chemotherapy in advanced colorectal carcinoma (ACRC), but the knowledge is still limited and partly conflicting.",
"One hundred and twenty-two patients with ACRC were treated with 5-fluorourac... | Immunohistochemical investigation of TS and p53 of the primary tumour is not useful to predict the outcome of palliative chemotherapy in ACRC. Instead, TS can be regarded as a marker for prediction of time to recurrence. | no |
12,559,019 | Does heart rate increase linearly in response to acute isovolemic anemia? | {
"contexts": [
"The cardiovascular response to acute isovolemic anemia in humans is thought to differ from that of other species. Studies of anesthetized humans have found either no change or a decreased heart rate. A previous study showed that in 32 healthy unmedicated humans, heart rate increased during acute ... | In 95 unmedicated, healthy humans, heart rate was a linear function of Hb during acute isovolemic anemia. Females had a significantly greater slope of increase in heart rate with decreasing Hb concentration than did males. The relationship is consistent among individuals, is similar to that reported for conscious dogs,... | yes |
12,553,949 | Is food production and wastage in relation to nutritional intake in a general district hospital -- wastage reduced by training the staff? | {
"contexts": [
"To assess the amount of food produced in a hospital kitchen and the amount wasted. To assess the amount of food eaten by patients in relation to their energy needs. To assess whether the food production and wastage could be reduced by training members of the staff.",
"The study was carried ou... | Despite a supply of food, which was much higher than the patients' needs, the patients have only approx. 60% of their energy need covered. We suggest a reorganization of nutrition in hospitals, so that this is made the responsibility of specific staff members. | no |
12,558,088 | Does peroral tramadol premedication increase postoperative nausea and delays home-readiness in day-case knee arthroscopy patients? | {
"contexts": [
"To evaluate the effect of preoperative oral tramadol on postoperative pain and its effect on the patient's home-readiness after diagnostic day-case knee arthroscopy performed under spinal anaesthesia.",
"We studied 156 outpatients in a prospective, randomized, double-blind fashion to examine ... | Preoperatively given slow-release tramadol is ineffective for reduction of postoperative pain after day-case arthroscopy of the knee. Additionally, preoperative tramadol is associated with higher incidence of PONV and it seems to cause delay in the patient's home-readiness. | yes |
19,841,979 | Does e2F1 expression predict outcome in Korean women who undergo surgery for breast carcinoma? | {
"contexts": [
"The transcriptional factors E2F1 and E2F2 have been reported to be associated with improved chemosensitivity in various cancers. We aimed to investigate whether E2F1 and E2F2 can be used as predictors of chemosensitivity in hormone-receptor-negative breast cancers (HRNBCs), which are common in Ko... | E2F1 may be a potential prognostic and predictive factor for clinical outcome and therapeutic results following adjuvant chemotherapy in HRNBC patients. | yes |
19,858,617 | Is hepatitis C virus-associated thrombocytopenia related to serum thrombopoietin levels? | {
"contexts": [
"Hepatitis C virus (HCV) infection is one of the most important health problems in Egypt. Thrombocytopenia is a common finding in subjects with chronic hepatitis. The precise etiology of this thrombocytopenia is still obscure. There is increasing interest in the potential role of thrombopoietin (T... | An impaired TPO production did not explain the development of thrombocytopenia in HCV and other mechanisms must be involved. | no |
19,845,671 | Is transient receptor potential ankyrin receptor 1 a novel target for pro-tussive agents? | {
"contexts": [
"The transient receptor potential ankyrin receptor 1 (TRPA1) is a cation channel, co-expressed with the pro-tussive transient receptor potential vanilloid type 1 (TRPV1) channel in primary sensory neurons. TRPA1 is activated by a series of irritant exogenous and endogenous alpha,beta-unsaturated a... | A novel pro-tussive pathway involves the TRPA1 channel, expressed by capsaicin-sensitive airway sensory nerves and is activated by a series of exogenous (cigarette smoke) and endogenous irritants. These results suggest TRPA1 may be a novel target for anti-tussive medicines. | yes |
19,845,676 | Does hyperlipidaemia induced by a high-cholesterol diet lead to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats? | {
"contexts": [
"Hyperlipidaemia interferes with cardioprotective mechanisms, but the cause of this phenomenon is largely unknown, although hyperlipidaemia impairs the cardioprotective NO-cGMP system. However, it is not known if natriuretic peptide-cGMP-protein kinase G (PKG) signalling is affected by hyperlipida... | This is the first demonstration that defects in the cardioprotective cGMP-PKG system could be a critical biochemical anomaly in hyperlipidaemia. | yes |
19,845,678 | Does haem oxygenase-1 induction protect against tumour necrosis factor alpha impairment of endothelial-dependent relaxation in rat isolated pulmonary artery? | {
"contexts": [
"Disturbances in pulmonary vascular reactivity are important components of inflammatory lung disease. Haem oxygenase-1 (HO-1) is an important homeostatic enzyme upregulated in inflammation. Here we have investigated the potentially protective effect of HO-1 against cytokine-induced impairment in p... | Induction of HO-1 protected against TNFalpha impairment of endothelium-dependent relaxation in pulmonary artery, by a mechanism involving a reduction in inducible NO synthase-derived NO production. | yes |
19,844,106 | Are high systolic and pulse pressure levels associated with better cognitive performance in patients with probable Alzheimer 's disease : a cross-sectional observational study in a geriatric outpatient population? | {
"contexts": [
"The prevalence of cardiovascular disease and Alzheimer's disease (AD) increases with age. A number of studies have demonstrated an association between AD and cardiovascular risk factors and disease. However, data are inconsistent.",
"Cross-sectional observational study in a geriatric outpatie... | Higher systolic blood pressure and pulse pressure were associated with a better cognitive test performance. Patients with probable AD and 2 or more cardiovascular diagnoses had lower MMSE scores. | yes |
19,853,477 | Is serum carboxymethyl-lysine , a dominant advanced glycation end product , associated with chronic kidney disease : the Baltimore longitudinal study of aging? | {
"contexts": [
"Advanced glycation end products (AGEs) are modifiable risk factors for renal disease that were primarily studied in persons with diabetes or endstage renal disease. Our objective was to characterize the relationship between AGEs and renal function in community-dwelling adults.",
"The presence... | Serum CML, a dominant AGE, is independently associated with CKD and eGFR. | yes |
19,840,987 | Does kIT ligand and bone morphogenetic protein signaling enhance human embryonic stem cell to germ-like cell differentiation? | {
"contexts": [
"Signaling mechanisms involved in early human germ cell development are largely unknown and believed to be similar to mouse germ cell development; however, there may be species specific differences. KIT ligand (KITL) and Bone morphogenetic protein 4 (BMP4) are necessary in mouse germ cell developm... | From these studies, we establish that KITL and BMP4 germ cell signaling affects in vitro formation of hESC derived germ-like cells and we suggest that they may play an important role in normal human germ cell development. | yes |
19,837,926 | Is defective O-glycosylation due to a novel homozygous S129P mutation associated with lack of fibroblast growth factor 23 secretion and tumoral calcinosis? | {
"contexts": [
"Homozygous mutations in fibroblast growth factor (FGF23) have recently been described as the genetic cause of one form of hyperphosphatemic tumoral calcinosis (HFTC). However, it remained unclear to date how these mutations lead to loss of biologically active FGF23 in the circulation.",
"We h... | Our data for the first time directly show that FGF23 mutations associated with HFTC impair O-glycosylation in vitro resulting in poor secretion of the mutant hormone thereby explaining the characteristic hyperphosphatemic phenotype of homozygous carriers in vivo. | yes |
19,837,925 | Does mild sleep restriction acutely reduce plasma glucagon levels in healthy men? | {
"contexts": [
"Sleep loss has repeatedly been suggested to affect glucose metabolism adversely, raising the question as to the impact of subtle forms of sleep loss.",
"The aim of the study was to assess the effects of a single night of sleep restriction to 4.5 h on endocrine parameters of glucose metabolism... | Our data show that mild restriction of nocturnal sleep to 4.5 h has a reducing effect on circulating glucagon levels. This finding provides further evidence for the notion that glucose homeostasis is sensitive to subtle changes in sleep duration. | yes |
19,837,921 | Is hypercortisolemia associated with severity of bone loss and depression in hypothalamic amenorrhea and anorexia nervosa? | {
"contexts": [
"Anorexia nervosa (AN) and functional hypothalamic amenorrhea (HA) are associated with low bone density, anxiety, and depression. Women with AN and HA have elevated cortisol levels. Significant hypercortisolemia, as in Cushing's disease, causes bone loss. It is unknown whether anxiety and depressi... | Hypercortisolemia is a potential mediator of bone loss and mood disturbance in these disorders. | yes |
19,847,310 | Does an eight-gene blood expression profile predict the response to infliximab in rheumatoid arthritis? | {
"contexts": [
"TNF alpha blockade agents like infliximab are actually the treatment of choice for those rheumatoid arthritis (RA) patients who fail standard therapy. However, a considerable percentage of anti-TNF alpha treated patients do not show a significant clinical response. Given that new therapies for tr... | The present 8-gene model obtained from whole blood expression efficiently predicts response to infliximab in RA patients. The application of the present system in the clinical setting could assist the clinician in the selection of the optimal treatment strategy in RA. | yes |
19,836,228 | Does vEGF and EMMPRIN expression correlate with survival of patients with osteosarcoma? | {
"contexts": [
"To investigate the clinicopathologic characteristics of Vascular Endothelial Growth Factor (VEGF) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) expression in osteosarcoma, and to evaluate the clinical significance of these two markers in the survival of osteosarcoma.",
"VEGF an... | According to our study, the overexpression of VEGF or EMMPRIN may be an important feature of osteosarcoma. A combined detection of VEGF/EMMPRIN co-expression may benefit us in prediction of a poor survival of osteosarcoma. | yes |
19,861,367 | Does heparin concentration-based anticoagulation for cardiac surgery fail to reliably predict heparin bolus dose requirements? | {
"contexts": [
"Hemostasis management has evolved to include sophisticated point-of-care systems that provide individualized dosing through heparin concentration-based anticoagulation. The Hepcon HMS Plus system (Medtronic, Minneapolis, MN) estimates heparin dose, activated clotting time (ACT), and heparin dose ... | The Hepcon HMS Plus system poorly estimates heparin bolus requirements in the pre-CPB period. Further prospective studies are needed to elucidate what constitutes adequate anticoagulation for CPB and how clinicians can reliably and practically assess anticoagulation in the operating room. | yes |
19,836,757 | Are serial prostate biopsies associated with an increased risk of erectile dysfunction in men with prostate cancer on active surveillance? | {
"contexts": [
"We determined whether serial prostate needle biopsies predispose men to erectile dysfunction and/or lower urinary tract symptoms over time.",
"Men with prostate cancer on an active surveillance protocol were administered the 5-item Sexual Health Inventory for Men and International Prostate Sy... | Serial prostate biopsies appear to have an adverse effect on erectile function in men with prostate cancer on active surveillance but do not affect lower urinary tract symptoms. | yes |
19,837,405 | Does pre-treatment with glutamine attenuate lung injury in rats subjected to intestinal ischaemia-reperfusion? | {
"contexts": [
"Glutamine (Gln) is the most abundant amino acid in blood and tissue fluids and is considered to be essential in certain catabolic conditions. A series of studies has shown that glutamine can attenuate cytokine release, reduce organ damage and improve survival in a rat model of endotoxaemia. The h... | Ischaemia-reperfusion injury increases the expression of ICAM-1 in the lung. This may contribute to the migration, accumulation and activation of neutrophils. Pre-treatment with Gln attenuates rat lung injury and reduces ICAM-1 expression. | yes |
19,854,711 | Do blood dendritic cells in systemic lupus erythematosus exhibit altered activation state and chemokine receptor function? | {
"contexts": [
"Dendritic cells (DCs) have a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). Reduced numbers of blood DCs and the accumulation of DCs at inflammatory sites have been observed in SLE. One crucial feature of DCs is their ability to migrate.",
"To analyse the maturation/a... | The phenotypic and migratory disturbances observed in SLE blood DCs could result in altered distribution of DCs in peripheral tissues, contributing to dysregulated immune responses and autoimmunity. | yes |
19,839,247 | Is epistaxis of patients admitted in the emergency department indicative of underlying arterial hypertension? | {
"contexts": [
"To assess the association between epistaxis and arterial hypertension.",
"A prospective study was conducted in 80 patients admitted in the emergency department, 42 with epistaxis and 38 well-matched controls. Blood pressure was measured upon admission and by continuous 24-hour ambulatory moni... | Although studies with larger series of patients are mandatory, epistaxis does not seem to result from underlying arterial hypertension. | no |
19,861,252 | Does [ P38MAPK pathway regulate COX-2 and caspase-3 expression in a mouse model of Parkinson disease ]? | {
"contexts": [
"To investigate the effect of p38 mitogen-activated protein kinase (p38MAPK) on the expression of COX-2 and caspase-3 in the substania nigra (SN) of mice with MPTP-induced Parkinson disease (PD).",
"C57BL/CN mice were treated with MPTP to prepare a subacute PD model, and their behavioral chang... | P38MAPK regulates the inflammation and apoptosis in the SN of the mouse model of subacute PD, and SB203580 may provide some neuroprotective effect. | yes |
19,857,181 | Is the osteogenic response of undifferentiated human mesenchymal stem cells ( hMSCs ) to mechanical strain inversely related to body mass index of the donor? | {
"contexts": [
"While the importance of physical factors in the maintenance and regeneration of bone tissue has been recognized for many years and the mechano-sensitivity of bone cells is well established, there is increasing evidence that body fat constitutes an independent risk factor for complications in bone... | The osteogenic marker genes were all statistically significantly upregulated by CTS, which was accompanied by a significant increase in cell-based ALP activity. Linear correlation analysis revealed that there was a significant correlation between phenotypic CTS response and the body mass index of the donor (r = -0.91, ... | yes |
19,861,448 | Is rituximab-mediated cell signaling and chemo/immuno-sensitization of drug-resistant B-NHL independent of its Fc functions? | {
"contexts": [
"Rituximab [chimeric anti-CD20 monoclonal antibody], alone or combined with chemotherapy, is used in the treatment of non-Hodgkin's lymphoma (NHL). Rituximab binds to CD20 and inhibits intracellular survival/growth pathways leading to chemo/immunosensitization of tumor cells in vitro. The contribu... | These findings reveal that rituximab-mediated inhibition of intracellular signaling pathways and leading to chemo/immuno-sensitization of resistant B-NHL is Fc independent. | yes |
19,861,441 | Are tumor-derived tissue factor-bearing microparticles associated with venous thromboembolic events in malignancy? | {
"contexts": [
"Despite the strong association between malignant disease and thromboembolic disorders, the molecular and cellular basis of this relationship remains uncertain. We evaluated the hypothesis that tumor-derived tissue factor-bearing microparticles in plasma contribute to cancer-associated thrombosis.... | We conclude that tumor-derived tissue factor-bearing microparticles are associated with VTE in cancer patients and may be central to the pathogenesis of cancer-associated thrombosis. | yes |
19,856,273 | Does surface protein EF3314 contribute to virulence properties of Enterococcus faecalis? | {
"contexts": [
"Identification of putative new virulence factors as additional targets for therapeutic approaches alternative to antibiotic treatment of multi-resistant enterococcal infections.",
"The EF3314 gene, coding for a putative surface-exposed antigen, was identified by the analysis of the Enterococc... | EF3314 is a newly described, surface exposed protein that contributes to the virulence properties of E. faecalis. | yes |
19,847,583 | Does posterior displacement of the tibia increase in deep flexion of the knee? | {
"contexts": [
"Deep knee flexion is important to proper function for some activities and in some cultures, although there are large posterior forces during high knee flexion. Most of what we know about posterior restraint and stability, however, has not been determined from deep flexion and without distinguishi... | Posterior displacement was larger in the lateral compartment at both flexion angles with manual posterior stress. As the knees flexed from 90 degrees to 135 degrees , posterior displacement became larger in the lateral compartment. | yes |
19,855,261 | Is signet ring cell histology an independent predictor of poor prognosis in gastric adenocarcinoma regardless of tumoral clinical presentation? | {
"contexts": [
"To test the hypothesis that signet ring cell (SRC) histology has a negative prognostic value in patients with gastric adenocarcinoma (ADC).",
"In western countries, gastric ADC with SRC often occurs after the disease has advanced. Consequently, the prognosis of SRC is generally regarded as po... | This study is currently the best evidence showing that SRC is a major and independent predictor of poor prognosis due to specific characteristics such as more infiltrating tumors showing affinity for lymphatic tissue accompanied by a higher rate of peritoneal carcinomatosis. Our results suggest the need for a specific ... | yes |
19,864,505 | Does progressive chondrocyte death after impact injury indicate a need for chondroprotective therapy? | {
"contexts": [
"Impact injury to articular cartilage can lead to posttraumatic osteoarthritis.",
"This study tests the hypotheses that (1) chondrocyte injury occurs after impact at energies insufficient to fracture the cartilage surface, and that (2) cartilage injury patterns vary with impact energy, time af... | These data showing progressive chondrocyte death after impact injury at energies insufficient to fracture the cartilage surface demonstrate a potential need for early chondroprotective therapy. | yes |
19,843,511 | Do beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice? | {
"contexts": [
"Beta2 integrin-mediated adhesion is thought to be a key event in cardiovascular disease. However, results of clinical trials targeting these molecules have been disappointing. Here, we investigated the effect of inactivation of beta2 integrins at different stages of atherosclerosis by timed bone ... | beta2 integrin-mediated interaction between leucocytes and the vessel wall is a time-dependent and dynamic process. During the initiation phase, it protects against atherosclerotic lesion formation. However, with the evolution of the lesion and chronic exposure to dyslipidaemia, beta2 integrins' pro-atherogenic action ... | yes |
19,843,512 | Does complete loss of murine Xin result in a mild cardiac phenotype with altered distribution of intercalated discs? | {
"contexts": [
"Xin is a striated muscle-specific F-actin binding protein that has been implicated in cardiomyopathies. In cardiomyocytes, Xin is localized at intercalated discs (IDs). Mice lacking only two of the three Xin isoforms (XinAB(-/-) mice) develop severe cardiac hypertrophy. To further investigate the... | Total Xin deficiency leads to topographical ID alterations, premature fibrosis and subtle changes in contractile behaviour; this is a milder cardiac phenotype than that observed in XinAB(-/-) mice, which still can express XinC. Together with the finding that XinC is detected solely in cardiomyopathic human tissues, thi... | yes |
19,850,688 | Are self-reported sleep duration and sleep disturbance independently associated with cortisol secretion in the Whitehall II study? | {
"contexts": [
"The association of short sleep duration with cortisol secretion has not been thoroughly examined in large community dwelling populations and the relative importance of short sleep duration and sleep disturbance is unclear.",
"The objective of the study was to assess the relationships between ... | Short sleep duration and increased sleep disturbances are independently associated with diurnal slope in cortisol secretion of a large community-based cohort of middle-aged men and women. | yes |
19,838,299 | Does dAZL relieve miRNA-mediated repression of germline mRNAs by controlling poly ( A ) tail length in zebrafish? | {
"contexts": [
"During zebrafish embryogenesis, microRNA (miRNA) miR-430 contributes to restrict Nanos1 and TDRD7 to primordial germ cells (PGCs) by inducing mRNA deadenylation, mRNA degradation, and translational repression of nanos1 and tdrd7 mRNAs in somatic cells. The nanos1 and tdrd7 3'UTRs include cis-acti... | Our present study indicated that DAZL acts as an "anti-miRNA factor" during vertebrate germ cell development. Our data also suggested that miRNA-mediated regulation can be modulated on specific target mRNAs through the poly(A) tail control. | yes |
19,858,404 | Do in situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer? | {
"contexts": [
"Many patients who present with early-stage colorectal cancer (International Union Against Cancer TNM stages I and II) are nevertheless at high risk of relapse. We hypothesized that intratumoral immune reaction could influence their prognosis.",
"The intratumoral immune reaction was investigat... | The combined analysis of CD8(+) plus CD45RO(+) cells in specific tumor regions could provide a useful criterion for the prediction of tumor recurrence and survival in patients with early-stage colorectal cancer. | yes |
19,866,456 | Does metabolic response of tomato leave upon different plant-pathogen interactions? | {
"contexts": [
"Plants utilise various defence mechanisms against their potential biotic stressing agents such as viroids, viruses, bacteria or fungi and abiotic environmental challenges. Among them metabolic alteration is a common response in both compatible and incompatible plant-pathogen interactions. However... | NMR metabolomics is a potent platform to analyse the compounds involved in different plant infections. A broad response to different pathogenic infections was revealed at metabolomic levels in the plant. Also, metabolic specificity against each pathogen was observed. | yes |
19,855,034 | Does anxiety predict poor perceived health in patients with an implantable defibrillator? | {
"contexts": [
"Implantation with an implantable cardioverter defibrillator (ICD) may cause psychological problems, including anxiety.",
"The objective was to determine whether general anxiety and disease-specific anxiety differentially predict poor perceived health in ICD patients.",
"Patient concerns a... | Identifying and supporting ICD patients with various anxiety symptoms is important. Future research should examine the differential predictive value of different forms of anxiety toward medical endpoints as well as possible interventions for disease-related anxiety. | yes |
19,857,759 | Is c-reactive protein in bronchoalveolar lavage fluid associated with markers of airway inflammation after lung transplantation? | {
"contexts": [
"C-reactive protein (CRP), an acute-phase marker of systemic inflammation, may also be a local regulator of the pulmonary immune system. Its role in lung transplantation (LT), however, is unclear. We hypothesized that CRP in bronchoalveolar lavage (BAL) fluid might be associated with airway inflam... | The current data corroborate a possible role for CRP in airway inflammation after LT. Its importance for BOS should therefore be further elucidated. | yes |
19,835,625 | Do subgingival bacterial colonization profiles correlate with gingival tissue gene expression? | {
"contexts": [
"Periodontitis is a chronic inflammatory disease caused by the microbiota of the periodontal pocket. We investigated the association between subgingival bacterial profiles and gene expression patterns in gingival tissues of patients with periodontitis. A total of 120 patients undergoing periodonta... | Our findings suggest that the microbial content of the periodontal pocket is a determinant of gene expression in the gingival tissues and provide new insights into the differential ability of periodontal species to elicit a local host response. | yes |
19,847,451 | Are specific secretory phase endometrial leukocytes of women with two and more consecutive idiopathic abortions significantly different from healthy controls? | {
"contexts": [
"To analyze concentrations of endometrial leukocytes in patients with idiopathic-repeated abortions.",
"Biopsies of exactly dated secretory endometrium in 25 patients with idiopathic-repeated abortions and 10 control patients without a history of miscarriage were compared with respect to the c... | This study suggests that the concentrations of specific endometrial leukocytes in a non-pregnant cycle are not associated with repeated pregnancy loss. Thus, the hypothesis of an altered endometrial immunity in patients with repeated miscarriages, symbolized by persistently differing local immune-cell concentrations, h... | no |
19,859,543 | Does study of human RIG-I polymorphisms identify two variants with an opposite impact on the antiviral immune response? | {
"contexts": [
"RIG-I is a pivotal receptor that detects numerous RNA and DNA viruses. Thus, its defectiveness may strongly impair the host antiviral immunity. Remarkably, very little information is available on RIG-I single-nucleotide polymorphisms (SNPs) presenting a functional impact on the host response.",
... | Hence, this study characterized P(229)fs and S(183)I SNPs as major functional RIG-I variants and potential genetic determinants of viral susceptibility. This work also demonstrated that serine 183 is a residue that critically regulates RIG-I-induced antiviral signaling. | yes |
19,841,890 | Is the interferon-induced helicase IFIH1 Ala946Thr polymorphism associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations? | {
"contexts": [
"The rs1990760 polymorphism (Ala946Thr) of interferon induced with helicase C domain 1 (IFIH1) has been proposed to associate with type 1 diabetes. In this study, association between IFIH1 Ala946Thr and type 1 diabetes was investigated in two distinct white populations, the Hungarians and Finns.",... | This study represents the first independent confirmation of the association between type 1 diabetes and the IFIH1 gene in Hungarian and Finnish populations. Summarising the data published so far, a clear association between the Ala946Thr polymorphism and type 1 diabetes was detected, with an apparent difference in the ... | yes |
19,844,095 | Is tIMP-2 gene polymorphism associated with intracerebral hemorrhage? | {
"contexts": [
"Both ischemic stroke and intracerebral hemorrhage are associated with altered expression and activation of matrix metalloproteinases (MMPs). Particularly relevant are MMP-2 and MMP-9. This proteolytic effect is dampened by tissue inhibitors of metalloproteinases (TIMPs). TIMP-2 is an important en... | We investigated a SNP 261 base pairs upstream of the start codon in exon 1 of TIMP-2. Our data suggest that carriers of homozygosity for allele A are at increased risk of developing intracerebral hemorrhage. | yes |
19,844,094 | Are post-stroke depressive symptoms associated with post-stroke characteristics? | {
"contexts": [
"Several studies have described the frequency and risk factors of post-stroke depressive symptoms (PSDS). However, most studies did not exclude patients with depressive symptoms shortly before stroke and paid little attention to prestroke risk factors of depression, including previous depressive e... | This is the largest study that investigated the prevalence and risk factors of PSDS by carefully excluding patients with depressive symptoms shortly before stroke. PSDS were not related to lesion side or location, but to the degree of post-stroke handicap and functional independence. Early detection of PSDS and their r... | yes |
19,844,092 | Does simultaneous ring voice-over-Internet phone system enable rapid physician elicitation of explicit informed consent in prehospital stroke treatment trials? | {
"contexts": [
"Cellular phone conversations between on-scene patients or their legally authorized representatives (LARs) and off-scene enrolling physician-investigators require immediate and reliable connection systems to obtain explicit informed research consent in prehospital treatment trials.",
"The NIH ... | The simultaneous ring system was reliable and effective, permitting enrollment of a substantial number of patients within the first hour after stroke onset. VOIP cellular networks with simultaneous ring are a preferred means of facilitating consent in prehospital treatment trials. | yes |
19,850,898 | Is higher systolic blood pressure associated with increased water diffusivity in normal-appearing white matter? | {
"contexts": [
"Hypertension is associated with the development of white matter lesions in older people. Diffusion tensor MRI can detect subtle, previsible white matter damage, but relationships between diffusion tensor MRI parameters and blood pressure (BP) remain unclear. We examined correlations among mean di... | The increase in MD without change in fractional anisotropy indicates that, in normal-appearing white matter, higher BP may be associated with increased extracellular fluid before any cytoarchitectural damage occurs. | yes |
19,863,500 | Is topical photodynamic therapy immunosuppressive in humans? | {
"contexts": [
"Visible light irradiation after application of a photosensitizer (topical photodynamic therapy; PDT) is increasingly used to treat nonmelanoma skin cancers and premalignant actinic keratoses. PDT can provide a cosmetically superior alternative to surgery, but carries failure rates of 10-40%. Whil... | Topical PDT induced significant immune suppression, which could impair local antitumour immune responses and may thus contribute to treatment failure. | yes |
19,840,991 | Is long-term outcome of endoscopic dilatation in patients with Crohn 's disease affected by disease activity or medical therapy? | {
"contexts": [
"Endoscopic dilatation of Crohn's disease-related strictures is an alternative to surgical resection in selected patients. The influence of disease activity and concomitant medical therapy on long-term outcomes is largely unknown.",
"To study the long-term safety and efficacy of stricture dila... | This largest series ever reported confirms that long term efficacy of endoscopic dilatation of Crohn's disease outweighs the complication risk. Neither active disease at the time of dilatation nor medical therapy afterwards predict recurrent dilatation or surgery. | no |
19,837,933 | Is genetic predisposition to elevated serum thyrotropin associated with exceptional longevity? | {
"contexts": [
"Exceptional longevity is associated with raised serum TSH.",
"The aim of this study was to examine whether offspring of people with exceptional longevity have elevated serum TSH and whether specific single nucleotide polymorphisms (SNPs) in the TSH-B gene and TSH receptor (TSHR) gene are asso... | A heritable phenotype characterized by raised serum TSH is associated with human longevity. Carriers of rs12050077 and rs10149689 SNPs in the TSHR have higher serum TSH, possibly contributing to decreased thyroid function and longevity. | yes |
19,837,610 | Is ventricular unloading associated with increased 20s proteasome protein expression in the myocardium? | {
"contexts": [
"The ubiquitin-proteasome system (UPS) breaks down misfolded and normal proteins, including cell cycle regulatory proteins involved in cardiac hypertrophy. Because congestive heart failure (CHF) increases cardiomyocyte cellular mass, indicative of increased protein synthesis and/or impaired breakd... | Our data indicate that: (1) the UPS is depressed in CHF; and (2) this is reversed by ventricular unloading and associated with decreased cardiomyocyte hypertrophy, mean DNA content, and cell cycle regulatory proteins. The findings support the view that the UPS is involved in both the pathogenesis of cardiac hypertrophy... | yes |
19,842,559 | Do [ Effects of arginine enriched enteral nutrition on nutritional status and cellular immunity in burn patients ]? | {
"contexts": [
"To investigate the effects of arginine enriched enteral nutrition (EN) on nutritional status and cellular immunity of severely burned patients.",
"Randomized, single blind, parallel and positive control investigation was employed in the study. Thirty severely burned patients were divided into... | Arginine enriched enteral nutrition can effectively improve nutritional status and cellular immune function of burn patients. | yes |
19,836,237 | Do the MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation? | {
"contexts": [
"Human MST/hSAV/LATS/hMOB tumor suppressor cascades are regulators of cell death and proliferation; however, little is known about other functions of MST/hMOB signaling. Mob1p, one of two MOB proteins in yeast, appears to play a role in spindle pole body duplication (the equivalent of mammalian ce... | Our observations propose a novel pathway in control of human centriole duplication after recruitment of HsSAS-6 to centrioles. | yes |
19,842,790 | Are arm/shoulder problems in breast cancer survivors associated with reduced health and poorer physical quality of life? | {
"contexts": [
"Except for lymphedema, the consequences of arm/shoulder problems (ASPs), at long-term in breast cancer survivors (BCSs) have hardly been studied. We examined demography, lifestyle, quality of life (QoL) and somatic morbidity in BCSs with and without ASPs. We also compared the associations of rest... | In BCSs, at four years after treatment, having ASP was associated with mastectomy, minimal physical activity and poorer physical QoL. Poor physical QoL is strongly associated with reduced shoulder abduction rather than with lymphedema. | yes |
19,854,708 | Do total cholesterol and LDL levels decrease before rheumatoid arthritis? | {
"contexts": [
"To compare lipid profiles in patients with rheumatoid arthritis (RA) and in non-RA subjects during the 5 years before and 5 years after the RA incidence/index date.",
"Lipid measures were abstracted in a population-based incident cohort of patients with RA (1987 American College of Rheumatolo... | TC and LDL levels and the prevalence of abnormal TC or LDL measures decreased significantly during the 5 years before the RA incidence/index date in patients with RA as compared with the non-RA cohort. These trends in lipid profile in RA are unlikely to be solely due to lipid-lowering treatment. | yes |
19,863,414 | Does efficient use of automatic exposure control systems in computed tomography require correct patient positioning? | {
"contexts": [
"Image quality and radiation dose to the patient are important factors in computed tomography (CT). To provide constant image quality, tube current modulation (TCM) performed by automatic exposure control (AEC) adjusts the tube current to the patient's size and shape.",
"To evaluate the effect... | This study demonstrates that patient centering markedly affects the efficacy of AEC function and that tube current changes vary between scanners. Tube position when acquiring the scout projection radiograph is decisive for the direction of the mAs change. Off-center patient positions cause errors in tube current modula... | yes |
19,852,667 | Is domain 3 of hepatitis C virus core protein sufficient for intracellular lipid accumulation? | {
"contexts": [
"Hepatitis C virus (HCV) is a major cause of liver disease worldwide, with steatosis, or \"fatty liver,\" being a frequent histologic finding. In previous work, we identified sequence polymorphisms within domain 3 (d3) of genotype 3 HCV core protein that correlated with steatosis and in vitro lipi... | Our results suggest that HCV core d3 is sufficient to mediate the accumulation of lipid by means of a mechanism that is independent of domains 1 and 2. Our results also suggest that altered lipid trafficking may be involved. | yes |
19,846,691 | Do zonal chondrocyte subpopulations reacquire zone-specific characteristics during in vitro redifferentiation? | {
"contexts": [
"If chondrocytes from the superficial, middle, and deep zones of articular cartilage could maintain or regain their characteristic properties during in vitro culture, it would be feasible to create constructs comprising these distinctive zones.",
"Zone-specific characteristics of zonal cell po... | Chondrocytes isolated from the 3 zones of equine cartilage can restore their zone-specific matrix expression when cultured in alginate after in vitro expansion. | yes |
19,843,777 | Does acute methadone treatment reduce myocardial infarct size via the delta-opioid receptor in rats during reperfusion? | {
"contexts": [
"Methadone is an opioid agonist often given to manage acute and chronic pain. We sought to determine whether methadone compared with morphine dose dependently reduces myocardial infarct size (IS) and whether the mechanism is delta-opioid receptor mediated. Furthermore, we examined whether myocardi... | These findings demonstrate that methadone and morphine produce similar myocardial IS-sparing effects that are delta-opioid receptor mediated and that are dependent on the duration of myocardial ischemia. | yes |
19,854,420 | Are trunk muscle attributes associated with balance and mobility in older adults : a pilot study? | {
"contexts": [
"To determine whether trunk muscle attributes are associated with balance and mobility performance among mobility-limited older adults.",
"Cross-sectional analysis of data from a randomized clinical trial.",
"Outpatient rehabilitation research center.",
"Community-dwelling older adults... | Trunk endurance and strength can be safely measured in mobility-limited older adults and are associated with both balance and mobility performance. Trunk endurance and trunk strength are physiologic attributes worthy of targeting in the rehabilitative care of mobility-limited older adults. | yes |
19,851,105 | Do intratubular hydrodynamic forces influence tubulointerstitial fibrosis in the kidney? | {
"contexts": [
"Renal epithelial cells respond to mechanical stimuli with immediate transduction events (e.g. activation of ion channels), intermediate biological responses (e.g. changes in gene expression), and long-term cellular adaptation (e.g. protein expression). Progressive renal disease is characterized b... | In conclusion, intratubular biomechanical forces, stretch, and fluid shear stress generate changes in intracellular signaling and gene expression that contribute to the pathobiology of obstructive and nonobstructive kidney disease. | yes |
19,840,363 | Does the glycoprotein Ibalpha-von Willebrand factor interaction induce platelet apoptosis? | {
"contexts": [
"The interaction of glycoprotein (GP) Ibalpha with von Willebrand factor (VWF) initiates platelet adhesion, and simultaneously triggers intracellular signaling cascades leading to platelet aggregation and thrombus formation. Some of the signaling events are similar to those occurring during apopto... | This study demonstrates that the GPIbalpha-VWF interaction induces apoptotic events in platelets, and that the association of 14-3-3zeta with the cytoplasmic domain of GPIbalpha is essential for apoptotic signaling. This finding may suggest a novel mechanism for platelet clearance or some thrombocytopenic diseases. | yes |
19,854,029 | Is scarless healing of oral mucosa characterized by faster resolution of inflammation and control of myofibroblast action compared to skin wounds in the red Duroc pig model? | {
"contexts": [
"Scar formation following skin trauma can have devastating consequences causing physiological and psychosocial concerns. Currently, there are no accepted predictable treatments to prevent scarring which emphasizes a need for a better understanding of the wound healing and scar formation process.",... | Earlier resolution of the inflammatory reaction and reduced wound contraction may promote scarless oral mucosal wound healing. In addition, scar formation likely depends not only on the number of myofibroblasts but also on the extracellular environment which regulates their function. | yes |
19,863,186 | Are cYFRA21-1 and CEA useful markers for predicting the sensitivity to chemoradiotherapy of esophageal squamous cell carcinoma? | {
"contexts": [
"Chemoradiotherapy (CRT) is currently performed for patients with advanced esophageal carcinoma. Sensitivity of tumours to CRT differs from one case to another and may be influenced by the expression of biological molecules. The aim of this study was to identify biological markers which could pred... | CYFRA21-1 and CEA may be helpful in predicting the responsiveness in ESCC of primary lesions to CRT, although the results should be confirmed in larger, more homogeneous studies. | yes |
19,860,994 | Is poor dietary quality of complementary foods associated with multiple micronutrient deficiencies during early childhood in Mongolia? | {
"contexts": [
"To assess whether persistent micronutrient deficiencies in Mongolian children identified in our earlier biochemical study are associated with inadequacies in quantity and/or quality in their complementary diets.",
"A cross-sectional study of breast-fed children aged 6-23 months, randomly sele... | Complementary feeding in Mongolia is compromised by deficits in several micronutrients but not energy, in part because of frequent consumption of non-nutritious snacks. The latter may interfere with breast-feeding and should be avoided. Instead, wheat-based complementary foods should be enriched with affordable cellula... | yes |
19,851,775 | Does upregulation of endothelin receptors A and B in the nitrofen induced hypoplastic lung occur early in gestation? | {
"contexts": [
"Pulmonary hypoplasia and persistent pulmonary hypertension (PPH) aggravate clinical courses in congenital diaphragmatic hernia (CDH). Endothelin 1 enhances PPH by vasoconstriction and proliferation of vessel walls. Up-regulation of pulmonary Endothelin Receptors A and B (EDNRA, EDNRB) has been re... | Altered expression of EDNRA and EDNRB is an early event in lung morphogenesis in the nitrofen model. We speculate that pulmonary arteries in CDH become excessively muscularised in early fetal life, becoming unable to adapt normally at birth. | yes |
19,846,469 | Do polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis? | {
"contexts": [
"Chronic lung infection with Pseudomonas aeruginosa is the most severe complication for patients with cystic fibrosis (CF). This infection is characterised by endobronchial mucoid biofilms surrounded by numerous polymorphonuclear leucocytes (PMNs). The mucoid phenotype offers protection against th... | The results demonstrate that CF sputum contains PMNs with an active consumption of O(2) for O(-)(2) production and suggest that the respiratory burst is ongoing and causes accelerated O(2) depletion due to formation of O(-)(2) in the lungs of chronically infected patients with CF. | yes |
19,861,961 | Does tumour-targeted delivery of TRAIL using Salmonella typhimurium enhance breast cancer survival in mice? | {
"contexts": [
"An effective cancer therapeutic must selectively target tumours with minimal systemic toxicity. Expression of a cytotoxic protein using Salmonella typhimurium would enable spatial and temporal control of delivery because these bacteria preferentially target tumours over normal tissue.",
"We e... | These results show the pre-clinical utility of S. typhimurium as a TRAIL expression vector that effectively reduces tumour growth and extends host survival. | yes |
19,861,154 | Is enhancement of muscle cell glucose uptake by medicinal plant species of Canada 's native populations mediated by a common , metformin-like mechanism? | {
"contexts": [
"The purpose of the present study was to elucidate the mechanisms of action mediating enhancement of basal glucose uptake in skeletal muscle cells by seven medicinal plant products recently identified from the pharmacopeia of native Canadian populations (Spoor et al., 2006).",
"Activity of the... | The mechanism common to the seven products studied here is analogous to that of the antidiabetic drug Metformin. Of interest is the observation that metabolic stress need not be sustained in order to induce important adaptive responses. The results support the use of these products as culturally adapted treatments for ... | yes |
19,851,073 | Does antiapoptotic seminal vesicle protein IV induce histamine release from human FcepsilonRI+ cells? | {
"contexts": [
"Seminal vesicle protein number 4 (SV-IV) is a small, basic, multifunctional, intrinsically disordered secretory protein synthesized in large amounts by rat seminal vesicle epithelium under androgen transcriptional control. SV-IV-immunorelated proteins occur in other rat tissues and in humans.",
... | SV-IV protein induces in human FcepsilonRI+ cells the release of histamine, a proinflammatory, antiapoptotic and immunosuppressive biogenic amine. These data: (1) are consistent with the antiapoptotic and immunosuppressive properties of SV-IV; (2) confirm a regulatory feature of SV-IV on mammal inflammatory reactivity ... | yes |
19,851,079 | Is soluble e-selectin an inverse and independent predictor of left ventricular wall thickness in end-stage renal disease patients? | {
"contexts": [
"E-selectin is a specific endothelial cell product involved in leukocyte recruitment on the endothelium, which is an important early step in the reparative process following vascular damage. In end-stage renal disease (ESRD), the relationship of E-selectin with left ventricular function has been s... | This study demonstrates that soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in ESRD patients. | yes |
19,855,158 | Does dasatinib inhibit both osteoclast activation and prostate cancer PC-3-cell-induced osteoclast formation? | {
"contexts": [
"Therapies to target prostate cancer bone metastases have only limited effects. New treatments are focused on the interaction between cancer cells, bone marrow cells and the bone matrix. Osteoclasts play an important role in the development of bone tumors caused by prostate cancer. Since Src kinas... | Dasatinib inhibits osteoclast differentiation of mouse primary bone marrow-derived monocytes and PC-3 cell-induced osteoclast differentiation. Dasatinib also inhibits osteoclast degradation activity. Inhibiting osteoclast differentiation and activity may be an effective targeted therapy in patients with prostate cancer... | yes |
19,850,263 | Do bone marrow-derived B cells preserve ventricular function after acute myocardial infarction? | {
"contexts": [
"In view of evidence that mature cells play a role in modulating the stem cell niche and thereby stem cell potential and proliferation, we hypothesized that a mature bone marrow (BM) mononuclear cell (MNC) infusion subfraction may have particular potency in promoting hematopoietic or resident stem... | Intramyocardial injection of B cells into early post-ischemic myocardium preserved cardiac function by cardiomyocyte salvage. Other BM MNC subtypes were either ineffective or suppressed cardioprotection conferred by an enriched B cell population. | yes |
19,850,260 | Does optimal stent-sizing with intravascular ultrasound contribute to complete neointimal coverage after sirolimus-eluting stent implantation assessed by angioscopy? | {
"contexts": [
"The aim of this study was to explore the determinants of neointimal coverage after sirolimus-eluting stent (SES).",
"Although SES has significantly reduced in-stent restenosis by inhibiting neointimal hyperplasia, insufficient neointimal coverage after stenting might result in adverse outcome... | Adequate stent sizing relative to the vessel size might contribute to the angioscopically complete neointimal coverage after SES implantation. | yes |
19,846,973 | Is altered p53 and pRb expression predictive of response to BCG treatment in T1G3 bladder cancer? | {
"contexts": [
"The aim of this study was to determine the prognostic value of p53 and retinoblastoma protein (pRb) expression in patients with stage T1 grade 3 (T1G3) bladder cancer (BC) treated by transurethral resection of bladder tumour (TURBT) and intravesical instillations of bacillus Calmette-Guerin (BCG)... | This is the first study demonstrating that altered p53 and pRb expression are predictive of T1G3 BC response to BCG treatment. These findings provide grounds for inclusion and prospective validation of these markers in the decision-making process for treating BC. | yes |
19,850,713 | Is there inadequate evidence to determine the effectiveness of nonpharmacological and nonsurgical interventions for hand osteoarthritis : an overview of high-quality systematic reviews? | {
"contexts": [
"Patients with hand osteoarthritis are commonly treated by health care professionals (allied to medicine). Practice should be informed by updated evidence from systematic reviews of randomized controlled trials.",
"The purpose of this overview is to summarize the evidence from systematic revie... | In overviews, results are dependent on available systematic reviews. They are important tools to guide choice of interventions and locate areas where more research is needed, but they might not be useful for deciding specifically how interventions should be carried out. | yes |
19,850,579 | Do atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms? | {
"contexts": [
"Familial hypertrophic cardiomyopathy (FHC) is frequently caused by cardiac myosin-binding protein C (cMyBP-C) gene mutations, which should result in C-terminal truncated mutants. However, truncated mutants were not detected in myocardial tissue of FHC patients and were rapidly degraded by the ubi... | These data suggest that atrogin-1 specifically targets truncated M7t-cMyBP-C, but not WT-cMyBP-C, for proteasomal degradation and that MuRF1 indirectly reduces cMyBP-C levels by regulating the transcription of MHC. | yes |
19,843,505 | Is disruption of ST5 associated with mental retardation and multiple congenital anomalies? | {
"contexts": [
"The authors observed a patient with a cryptic subtelomeric de novo balanced translocation 46,XY.ish t(11;20)(p15.4;q13.2) presenting with severe mental retardation, muscular hypotonia, seizures, bilateral sensorineural hearing loss, submucous cleft palate, persistent ductus Botalli, unilateral cy... | Hence, the authors suppose that ST5 plays an important role in central nervous system development probably due to disturbance of DENN-domain-mediated vesicle formation and neurotransmitter trafficking. Thus, these findings implicate ST5 in the aetiology of mental retardation, seizures and multiple congenital anomalies. | yes |
19,846,066 | Do cocaine-specific antibodies blunt the subjective effects of smoked cocaine in humans? | {
"contexts": [
"Rates of relapse among cocaine-dependent patients are high, and new treatment approaches are needed. Clinical data demonstrate that a cocaine vaccine (TA-CD) produces selective anticocaine antibodies, yet the impact of these antibodies on cocaine's direct effects is unknown. The objective of this... | The TA-CD vaccine substantially decreased smoked cocaine's intoxicating effects in those generating sufficient antibody. These data support further testing of cocaine immunotherapy as a treatment for cocaine dependence. | yes |
19,846,062 | Does uncoupling the D1-N-methyl-D-aspartate ( NMDA ) receptor complex promote NMDA-dependent long-term potentiation and working memory? | {
"contexts": [
"Although dopamine D1 receptors are involved in working memory, how D1 receptors contribute to this process remains unclear. Numerous studies have shown that D1 receptors have extensive functional interaction with N-methyl-D-aspartate (NMDA) receptor. Our group previously demonstrated that D1 rece... | Our study showed a critical role of NMDA-D1 direct protein-protein interaction in NMDA receptor-mediated LTP and working memory and implicated the involvement of CaMKII in this process. | yes |
19,846,063 | Does subgenual prefrontal cortex activity predict individual differences in hypothalamic-pituitary-adrenal activity across different contexts? | {
"contexts": [
"Hypothalamic-pituitary-adrenal (HPA) system activation is adaptive in response to stress, and HPA dysregulation occurs in stress-related psychopathology. It is important to understand the mechanisms that modulate HPA output, yet few studies have addressed the neural circuitry associated with HPA ... | These findings suggest that activation in subgenual PFC may be related to HPA output across a variety of contexts (including familiar settings and novel or threatening situations). Individuals prone to elevated subgenual PFC activity across multiple contexts may be individuals who consistently show heightened cortisol ... | yes |
19,850,698 | Does multidimensional Prognostic Index based on a comprehensive geriatric assessment predict short-term mortality in older patients with heart failure? | {
"contexts": [
"Multidimensional impairment of older patients may influence the clinical outcome of diseases. The aim of this study was to evaluate whether a Multidimensional Prognostic Index (MPI) based on a comprehensive geriatric assessment predicts short-term mortality in older patients with heart failure.",... | The MPI, calculated from information collected in a standardized comprehensive geriatric assessment, is useful to estimate the risk of 1-month mortality in older patients with heart failure. | yes |
19,850,693 | Is preadipocyte factor-1 associated with marrow adiposity and bone mineral density in women with anorexia nervosa? | {
"contexts": [
"Despite having low visceral and sc fat depots, women with anorexia nervosa (AN) have elevated marrow fat mass, which is inversely associated with bone mineral density (BMD). Adipocytes and osteoblasts differentiate from a common progenitor cell, the human mesenchymal stem cell. Therefore, underst... | Pref-1 is elevated in AN. Pref-1, IGF-I, IGF-BP2 and leptin are associated with marrow adiposity and BMD. | yes |
19,842,161 | Does pain severity in eating disorders predict longer inpatient hospitalization? | {
"contexts": [
"This study examined pain intensity (PI) in eating disorders.",
"Comparisons between inpatients (N = 208) reporting moderate to severe pain (HiP) and no pain or mild pain (LoP) at admission were made, and the relationship between PI and treatment response was examined.",
"Patients with HiP... | This is the first observation of a relationship between pain and health care utilization in eating disorders. The results imply that pain management is an important component of treatment. | yes |
19,843,157 | Is outcome after device implantation in chronic heart failure dependent on concomitant medical treatment? | {
"contexts": [
"Device implantation in chronic heart failure (CHF) for cardiac resynchronization therapy (CRT) with or without implantable cardioverter/defibrillator (ICD) is an established treatment option for symptomatic patients under medical baseline therapy. Although recommended, the need for optimization o... | Our data stress the importance of professional monitoring and titration of pharmacotherapy not only in medically treated CHF patients but also in patients under device therapy by a heart failure unit or a specialized cardiologist. | yes |
19,865,469 | Do a qualitative and quantitative analysis of protein substitution in human burn wounds? | {
"contexts": [
"In major burn wounds of more than 15% total burn surface area mediator-associated reactions lead to capillary leak resulting in critical condition. Little is known about the efficiency of protein substitution. We quantified and qualified the systemic and local protein loss in burn patients during... | Substitution of human protein solutions such as Biseko can result in significantly higher serum protein and albumin concentrations as well as lower infection parameters. Higher serum immunoglobulins could help to decrease potential immunodeficiency. | yes |
19,859,719 | Does zinc deficiency impair wound healing of colon anastomosis in rats? | {
"contexts": [
"Anastomotic leakage is a relevant surgical complication. The aim of the study was to investigate the influence of a controlled preoperative zinc deficiency on the extracellular matrix composition of colon anastomosis.",
"Forty male Wistar rats were randomized to either a zinc deficiency group... | Our study constitutes the known negative effect of zinc deficiency on wound healing. Zinc deficiency significantly increased the activity of MMPs (2, 9, and 13), caused a reduced collagen type I/III ratio, and delayed cell proliferation and quality of intestinal wound healing. | yes |
19,863,298 | Is rOS1 Asp2213Asn polymorphism associated with coronary artery disease in a Greek case-control study? | {
"contexts": [
"Rs619203 (Cys2229Ser) and rs529038 (Asp2213Asn) polymorphisms in the ROS1 gene have been studied in relation to myocardial infarction (MI) yielding inconsistent results. We investigated the role of ROS1 rs529038 polymorphism in coronary artery disease (CAD) in Greeks using a case-control study.",... | Our findings do not support the hypothesis that ROS1 rs529038 polymorphism is an important contributing factor in the etiology of CAD in the Greek population. | no |
19,839,176 | Is age-related deterioration in flexibility associated with health-related quality of life in nonagenarians? | {
"contexts": [
"Studies indicate that age is associated with deterioration in physical function and a concomitant decrease in health-related quality of life (HRQL). The contribution of physical function to HRQL in nonagenarians (ages 90-99) is unknown. The purposes of this study were to examine age-related chang... | These data suggest that upper body flexibility continues to decline during the 10th decade of life and has implications for influence on aspects of HRQL in this segment of the population. | yes |
19,835,796 | Is maternal adnexal torsion in pregnancy associated with significant risk of recurrence? | {
"contexts": [
"To investigate the phenomenon of recurrent adnexal torsion during the same pregnancy, describe its risk factors, and suggest possible management of this entity.",
"Retrospective case-control study (Canadian Task Force classification II-3).",
"Gynecologic endoscopy unit in a university hos... | Pregnant women are at risk for recurrent torsion, especially when the ovaries are enlarged and ultrasound studies demonstrate multiple cysts. Cyst aspiration may prevent recurrent torsion during the same pregnancy. | yes |
19,859,555 | Do microrna-221 and microrna-222 modulate differentiation and maturation of skeletal muscle cells? | {
"contexts": [
"MicroRNAs (miRNAs) are a class of small non-coding RNAs that have recently emerged as important regulators of gene expression. They negatively regulate gene expression post-transcriptionally by translational repression and target mRNA degradation. miRNAs have been shown to play crucial roles in m... | miR-221 and miR-222 have been found to be modulated during myogenesis and to play a role both in the progression from myoblasts to myocytes and in the achievement of the fully differentiated phenotype. Identification of miRNAs modulating muscle gene expression is crucial for the understanding of the circuits controllin... | yes |
19,844,672 | Is pancreatic duct replication increased with obesity and type 2 diabetes in humans? | {
"contexts": [
"In a high-fat-fed rat model of type 2 diabetes we noted increased exocrine duct replication. This is a predisposing factor for pancreatitis and pancreatic cancer, both of which are more common in type 2 diabetes. The aim of the study reported here was to establish if obesity and/or type 2 diabete... | Pancreatic duct cell replication is increased in humans in response to both obesity and type 2 diabetes, potentially providing a mechanism for the increased risk of pancreatitis and pancreatic cancer in those with obesity and/or type 2 diabetes. | yes |
19,846,395 | Is renal phenotype of the cystinosis mouse model dependent upon genetic background? | {
"contexts": [
"Cystinosis is caused by mutations in CTNS that encodes cystinosin, the lysosomal cystine transporter. The most severe and frequent form is characterized by a proximal tubulopathy that appears around 6 to 12 months of age. In the absence of treatment, end-stage renal disease is reached by 10 years... | Thus, the C57BL/6 strain represents the first Ctns(-/-) mouse model to show clear renal defects. In addition to highlighting the influence of genetic background on phenotype, the C57BL/6 Ctns(-/-) mice represent a useful model for further understanding cystinosin function in the kidney and, specifically, in the proxima... | yes |
19,837,518 | Does acute HPA axis response to naltrexone differ in female vs. male smokers? | {
"contexts": [
"Both opioid antagonist administration and cigarette smoking acutely increase hypothalamic-pituitary-adrenal (HPA) axis activity as measured by adrenocorticotropic hormone (ACTH) and cortisol levels. However, male and female smokers may differ in their response to the opioid antagonist naltrexone,... | The findings support the hypothesis that women are more sensitive to opioid antagonism at the level of the HPA axis. Although further studies are needed to examine mechanisms underlying these responses, both results may have clinical implications for the use of naltrexone as a treatment for nicotine dependence. | yes |
19,845,544 | Does adenosine deaminase enzyme therapy prevent and reverses the heightened cavernosal relaxation in priapism? | {
"contexts": [
"Priapism featured with painful prolonged penile erection is dangerous and commonly seen in sickle cell disease (SCD). The preventive approaches or effective treatment options for the disorder are limited because of poor understanding of its pathogenesis. Recent studies have revealed a novel role ... | Our studies have identified that PEG-ADA is a novel, safe, and mechanism-based drug to prevent and correct excess adenosine-mediated increased cavernosal relaxation seen in two independent priapic animal models, and suggested its therapeutic possibility in men suffering from priapism. | yes |
19,845,547 | Does inhalation device allow novel administration of apomorphine in men with erectile dysfunction-efficacy and safety findings? | {
"contexts": [
"Erectile dysfunction (ED) treatment is greatly influenced by patient preference, and currently available oral therapies do not meet all patients' needs. New therapies and formulations are therefore being investigated.",
"The aim of this article is to assess the clinical efficacy and safety of... | The VR004 system administers low apomorphine doses that are well tolerated without compromising efficacy. This route of administration ensures a rapid onset of action and reproducible efficacy and safety profiles. Inhaled apomorphine is therefore a potential first-line treatment for ED. | yes |
19,842,931 | Is gRK5 Gln41Leu polymorphism associated with sensitivity to beta ( 1 ) -adrenergic blockade in humans? | {
"contexts": [
"A common, functionally significant polymorphism in GRK5 (Gln41Leu) encodes a gain-of-function enzyme that enhances desensitization of the beta(1)-adrenergic receptor. GRK5 Leu41 has been postulated to confer endogenous 'genetic beta-blockade' and contribute to an attenuated response to beta-block... | The GRK5 Gln41Leu polymorphism does not affect sensitivity to the beta(1)-adrenergic blocker, atenolol, during acute physiological adrenergic stimulation, nor does it contribute to the ethnic differences in sensitivity to atenolol among black and Caucasian individuals. | no |
19,837,940 | Does array comparative genomic hybridization profiling analysis reveal deoxyribonucleic acid copy number variations associated with premature ovarian failure? | {
"contexts": [
"Premature ovarian failure (POF) is defined by amenorrhea of at least 4- to 6-month duration, occurring before 40 yr of age, with two FSH levels in the postmenopausal range. Its etiology remains unknown in more than 80% of cases. Standard karyotypes, having a resolution of 5-10 Mb, have identified... | We report the first study of CNV analysis in a large cohort of Caucasian POF patients. In the eight statistically significant CNVs we report, we found five genes involved in reproduction, thus representing potential candidate genes in POF. The current study along with emerging information regarding CNVs, as well as dat... | yes |
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