pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
21,874,574 | Does closed suction drainage with or without re-transfusion of filtered shed blood offer advantages in primary non-cemented total hip replacement using a direct anterior approach? | {
"contexts": [
"Wondering if the use of drains allowing re-transfusion of shed blood as opposed to closed suction drains or no drains would improve quality of care to patients undergoing simple non-cemented primary total hip replacement (THR) using a direct anterior approach, a three-arm prospective randomized s... | The possibility to re-transfuse drained blood was not an argument for using drains and, accepting more thigh swelling, we stop to use drains in simple non-cemented primary THR using the direct anterior approach. | no |
21,886,003 | Does ideal tibial intramedullary nail insertion point vary with tibial rotation? | {
"contexts": [
"The aim of the study was to investigate how superior entry point varies with tibial rotation and to identify landmarks that can be used to identify suitable radiographs for successful intramedullary nail insertion.",
"The proximal tibia and knee were imaged for 12 cadaveric limbs undergoing 5... | The fibula head bisector line can be used to avoid choosing external rotation views and, thus, avoid medial insertion points. The current results may help the surgeon prevent malalignment during intramedullary nailing in proximal tibial fractures. | yes |
21,897,506 | Does pre-induction low dose pethidine decrease incidence of postoperative shivering in laparoscopic gynecological surgeries? | {
"contexts": [
"The incidence of shivering in patients undergoing a laparoscopic procedure is stated to be about 40%. A majority of laparoscopic gynecological procedures are taken up on an outpatient basis. Postoperative shivering may delay hospital discharge and is a common cause of discomfort in patients recov... | Prophylactic pre-induction, low-dose pethidine does not have major role in preventing postoperative shivering. | no |
21,872,265 | Is age-related Notch-4 quiescence associated with altered wall remodeling during vein graft adaptation? | {
"contexts": [
"The link of aging to specific mechanisms of vascular biology is not well understood. We have previously shown that aging is associated with increased vein graft wall thickness and that this process involves the VEGF-Delta/Notch-ephrin/Eph cascade. Therefore, we examined whether Dll-4 or Notch-4 a... | During vein graft adaptation to the arterial environment, both Dll-4 and Notch-4 expression are down-regulated in an aged, but not a young, background. Loss of Notch-4 is associated with loss of attenuation of neointima. The delta-Notch signaling pathway may be active during vein graft adaptation. | yes |
21,872,263 | Are inducible atrial tachycardias with multiple circuits in a stepwise approach associated with increased episodes of atrial tachycardias after catheter ablation? | {
"contexts": [
"Atrial tachycardia (AT) is commonly observed during catheter ablation (CA) in patients with atrial fibrillation (AF) undergoing a stepwise extensive CA. In this study, we examined the hypothesis that the presence of multiple inducible ATs (multiple-ATs), which allow for latent multiple reentrant ... | The presence of an atrial substrate allowing for multiple-ATs was associated with increased AT episodes during follow-up. | yes |
21,872,269 | Does dietary flaxseed protect against lung ischemia reperfusion injury via inhibition of apoptosis and inflammation in a murine model? | {
"contexts": [
"The hallmark of lung ischemia-reperfusion injury (IRI) is the production of reactive oxygen species (ROS), and the resultant oxidant stress has been implicated in apoptotic cell death as well as subsequent development of inflammation. Dietary flaxseed (FS) is a rich source of naturally occurring ... | We conclude that dietary FS is protective against lung IRI in a clinically relevant murine model, and this protective effect may in part be mediated by the inhibition of apoptosis and inflammation. | yes |
21,899,735 | Does osteoarthritis accelerate and exacerbates Alzheimer 's disease pathology in mice? | {
"contexts": [
"The purpose of this study was to investigate whether localized peripheral inflammation, such as osteoarthritis, contributes to neuroinflammation and neurodegenerative disease in vivo.",
"We employed the inducible Col1-IL1βXAT mouse model of osteoarthritis, in which induction of osteoarthritis... | This work supports a model by which peripheral inflammation triggers the development of neuroinflammation and subsequently the induction of AD pathology. Better understanding of the link between peripheral localized inflammation, whether in the form of osteoarthritis, atherosclerosis or other conditions, and brain infl... | yes |
21,876,213 | Is hypertension common among HIV-infected persons , but not associated with HAART? | {
"contexts": [
"With improved survival after the introduction of highly active antiretroviral therapy (HAART), non-AIDS-related morbidity and mortality have come to the forefront in the management of HIV patients. HAART has been linked to the development of several risk factors for cardiovascular disease includi... | Hypertension is common among HIV-infected persons and is associated with established risk factors, but not with HAART use. Given the high prevalence of hypertension and its association with duration of HIV infection, other factors such as virally-mediated endothelial changes or immune activation may play a role. Furthe... | yes |
21,873,287 | Does abaR4 replace AbaR3 in a carbapenem-resistant Acinetobacter baumannii isolate belonging to global clone 1 from an Australian hospital? | {
"contexts": [
"To explore the diversity of genomic resistance islands in multiply antibiotic-resistant Acinetobacter baumannii isolates in global clone 1 (GC1) from Australian hospitals.",
"PCR was used to characterize isolates, detect antibiotic resistance genes and insertion sequences and screen for genom... | Substantial diversity was observed among the GC1 isolates. This is the first report of AbaR4 replacing the AbaR3-type island seen in most GC1 isolates, and D36 represents a distinct new GC1 lineage. The AbaRs are members of a large, previously undocumented family of transposons that target comM. | yes |
21,879,940 | Does the role of worksite and home smoking ban in smoking cessation among U.S. employed adult female smokers? | {
"contexts": [
"Examine the association of work and home smoking bans with quitting behaviors among employed female smokers in the United States.",
"Secondary analyses using cross-sectional data from the 2006/2007 Tobacco Use Supplement to the Current Population Survey.",
"Nationally representative sampl... | Efforts to promote quitting behaviors among employed female smokers may be facilitated by increasing rates of complete smoking bans at both work and home settings. | yes |
21,873,563 | Does metabolic syndrome detect metabolic risk in African men living in the U.S? | {
"contexts": [
"Metabolic risk and metabolic syndrome (MetSyn) prevalence were compared in Africans who immigrated to the U.S. and African Americans. If MetSyn were an effective predictor of cardiometabolic risk, then the group with a worse metabolic risk profile would have a higher rate of MetSyn.",
"Cross-... | African immigrants have a worse metabolic profile than African Americans but a similar prevalence of MetSyn. Therefore, MetSyn may underpredict metabolic risk in Africans. | no |
21,873,561 | Are telomere dysfunction-related serological markers associated with type 2 diabetes? | {
"contexts": [
"Recent studies have identified a set of serological markers for telomere dysfunction and DNA damage. The relevance of these serological markers in type 2 diabetes remains elusive. We investigated the association of serological markers (elongation factor 1α [EF-1α], stathmin, and N-acetyl-glucosam... | Serological N-acetyl-glucosaminidase, telomere length, and the UCP2-886G>A variant are independent risk factors for type 2 diabetes. Serological N-acetyl-glucosaminidase correlates with telomere length but not with the UCP2-886G>A variant. | yes |
21,880,805 | Is shift work at young age associated with elevated long-term cortisol levels and body mass index? | {
"contexts": [
"The incidence of obesity and other features of the metabolic syndrome is increased in shift workers. This may be due to a misalignment between the internal circadian rhythm and the behavioral rhythm. The stress hormone cortisol could play a role in this phenomenon because it is secreted in a circ... | Shift work at a young adult age is associated with elevated long-term cortisol levels and increased BMI. Elevated cortisol levels and BMI may contribute to the increased cardiovascular risk found in shift workers. | yes |
21,880,800 | Does endothelin-1 stimulate proliferation of first-trimester trophoblasts via the A- and B-type receptor and invasion via the B-type receptor? | {
"contexts": [
"Endothelin-1 (ET-1) stimulates proliferation and invasion of first-trimester human trophoblast cells.",
"To test the hypothesis that ET-1 effects are mediated by different receptor subtypes [ET receptor (ETR)-A and ETR-B].",
"The location of ETR in trophoblast cell columns (wk 6-12) was i... | The effect of ET-1 on cell proliferation in first-trimester trophoblasts is mediated by both ETR, whereas its effect on invasion is mediated predominantly by ETR-B. These effects are in line with the receptor subtype location. | yes |
21,875,759 | Is basal cell carcinoma on the ear more likely to be of an aggressive phenotype in both men and women? | {
"contexts": [
"We observed that basal cell carcinoma (BCC) on the ear demonstrates a more aggressive phenotype compared with other body sites.",
"We sought to determine if it is statistically significant that BCC on the ear is more aggressive.",
"We queried our 2009 database for all BCCs biopsied from t... | The data were retrieved from a single year at our institution, and there could potentially be regional bias given that the population of data is from a single institution. Many of the specimens we evaluate are reviewed in consultation and may thus represent a selection bias. | yes |
21,902,454 | Does comparative genomics of thiol oxidoreductases reveal widespread and essential functions of thiol-based redox control of cellular processes? | {
"contexts": [
"Redox regulation of cellular processes is an important mechanism that operates in organisms from bacteria to mammals. Much of the redox control is provided by thiol oxidoreductases: proteins that employ cysteine residues for redox catalysis. We wanted to identify thiol oxidoreductases on a genome... | These data provide information about organization and properties of thiol-based redox control, whose use is increased with the increase in complexity of organisms. Our data also show an essential combined function of a set of thiol oxidoreductases, and of thiol-based redox regulation in general, in all living organisms... | yes |
21,871,080 | Does predictors of adherence to a multifaceted podiatry intervention for the prevention of fall in older people? | {
"contexts": [
"Despite emerging evidence that foot problems and inappropriate footwear increase the risk of falls, there is little evidence as to whether foot-related intervention strategies can be successfully implemented. The aim of this study was to evaluate adherence rates, barriers to adherence, and the pr... | Adherence to a multifaceted podiatry intervention in this trial ranged from 54 to 72%. People with better physical health, less fear of falling and a younger age exhibited greater adherence, suggesting that strategies need to be developed to enhance adherence in frailer older people who are most at risk of falling. | yes |
21,871,084 | Does a whole blood monokine-based reporter assay provide a sensitive and robust measurement of the antigen-specific T cell response? | {
"contexts": [
"The ability to measure T-cell responses to antigens is proving critical in the field of vaccine development and for understanding immunity to pathogens, allergens and self-antigens. Although a variety of technologies exist for this purpose IFNγ-ELISpot assays are widely used because of their sens... | A monokine-based reporter assay provides a sensitive measure of antigen-specific T cell activation. Assays can be performed on small volumes of whole blood and remain accurate despite delays in processing. This assay may be a useful tool for studying T cell responses, particularly when samples are limited in quantity o... | yes |
21,875,495 | Does intra-acinar trypsinogen activation mediate early stages of pancreatic injury but not inflammation in mice with acute pancreatitis? | {
"contexts": [
"The role of trypsinogen activation in the pathogenesis of acute pancreatitis (AP) has not been clearly established.",
"We generated and characterized mice lacking trypsinogen isoform 7 (T7) gene (T(-/-)). The effects of pathologic activation of trypsinogen were studied in these mice during in... | T7 is activated during pathogenesis of AP in mice. Intra-acinar trypsinogen activation leads to acinar death during early stages of pancreatitis, which accounts for 50% of the pancreatic damage in AP. However, progression of local and systemic inflammation in AP does not require trypsinogen activation. NF-κB is activat... | yes |
21,875,496 | Do luminal CD4⁺ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation? | {
"contexts": [
"The egress of memory T cells from peripheral tissues, such as lung and skin, into the draining lymph nodes requires their expression of CC chemokine receptor 7 (CCR7). In the intestine, resident memory T cells in the intestinal lamina propria (LP) do not express CCR7, indicating that they are tis... | CD4(+) T cells not only penetrate from the luminal side of the intestine to the LP but also actively egress from the LP into the circulation. We developed a rectal administration system that might be used to further investigate cell trafficking in intestinal mucosa and to develop enema-based therapeutics for intestinal... | yes |
21,890,874 | Does a clinical decision support need assessment of community-based physicians? | {
"contexts": [
"To conduct a grounded needs assessment to elicit community-based physicians' current views on clinical decision support (CDS) and its desired capabilities that may assist future CDS design and development for community-based practices.",
"To gain insight into community-based physicians' goals... | Physicians identified different aspects of decision-making in need of support: clinical decision-making such as medication administration and treatment, and cognitive decision-making that enhances relationships and interactions with patients and staff. | yes |
21,871,273 | Does small prosthesis size in aortic valve replacement affect mortality? | {
"contexts": [
"Small prosthesis size has been associated with poorer postoperative outcomes in aortic valve replacement (AVR). We hypothesized that the use of small aortic valve (AV) prostheses does not independently increase operative mortality following AVR, but that mortality may instead be related to comorb... | Small aortic valve prosthesis size does not independently increase operative mortality following primary AVR. Increased morbidity and mortality among patients undergoing the implantation of small AV prostheses is related to the confounding effects of preoperative and operative risk factors. Annular enlargement may not ... | no |
21,893,970 | Are preventive scleral buckling and silicone oil tamponade important for posttraumatic endophthalmitis successfully managed with vitrectomy? | {
"contexts": [
"Posttraumatic endophthalmitis (PTE) managed with pars plana vitrectomy (PPV) and a variety of other methods often resulted in retinal detachment (RD), which deteriorates postoperative visual acuity (VA). We investigated initial ocular conditions, surgical management and outcomes of PTE patients a... | Preventive scleral buckling and silicone oil tamponade are important for patients with good initial VA (VA>LP) to be successfully managed by PPV. | yes |
21,898,098 | Does hypoxemia correlate with attentional dysfunction in patients with obstructive sleep apnea? | {
"contexts": [
"Obstructive sleep apnea is associated with cognitive impairment, but whether hypoxemia or repeated arousals and sleepiness are the underlying mechanism is controversial. Studies using a wide range of attention and executive functions tests in patients with severe sleep apnea are lacking.",
"I... | Attention is the predominant cognitive function affected in patients with obstructive sleep apnea and correlates primarily with nocturnal hypoxemia rather than daytime sleepiness or sleep fragmentation. Executive functions, while below average in some patients, do not correlate with polysomnographic parameters. | yes |
21,898,091 | Is wilms ' tumor protein 1 ( WT1 ) peptide vaccination in AML patients : predominant TCR CDR3β sequence associated with remission in one patient detectable in other vaccinated patients? | {
"contexts": [
"Clinically effective T-cell responses can be elicited by single peptide vaccination with Wilms' tumor 1 (WT1) epitope 126-134 in patients with acute myeloid leukemia (AML). We recently showed that a predominant T-cell receptor (TCR) β chain was associated with vaccine-induced complete remission i... | We provide the first data addressing TCR Vβ chain usage in WT1-specific T-cell populations after HLA A*0201-restricted single peptide vaccination. We demonstrate both shared Vβ restriction and the sharing of a TCR β transcript with proven clinical impact in one patient. | yes |
21,898,090 | Does gastrokine 1 function as a tumor suppressor by inhibition of epithelial-mesenchymal transition in gastric cancers? | {
"contexts": [
"Gastrokine 1 (GKN1) plays an important role in the gastric mucosal defense mechanism and also acts as a functional gastric tumor suppressor. The specific aim of this study was to determine the molecular mechanisms underlying GKN1 tumor suppressor activity in the progression of gastric cancers.",
... | These data suggest that the GKN1 gene may play an important role in the progression of sporadic gastric cancers via inhibition of EMT and cancer cell migration. | yes |
21,877,905 | Is thymosin beta 4 associated with collateral development in coronary artery disease? | {
"contexts": [
"Thymosin beta 4 (Tβ4) plays an essential role in cardiac vessel development and is currently being developed as a therapeutic agent for the treatment of coronary artery disease (CAD) in some experimental studies. Thus, we aimed to investigate the association of serum Tβ4 levels and collateral for... | Our findings suggest that serum Tβ4 levels are significantly associated with the collateral development in severe CAD. | yes |
21,882,214 | Is tumor focality associated with biochemical outcome after radical prostatectomy? | {
"contexts": [
"The clinical and prognostic significance of unifocal prostatic carcinoma is not clearly understood. In the current study, we sought to characterize the clinical and pathologic characteristics of unifocal and multifocal prostate cancers and to investigate the effects of tumor focality on biochemic... | Tumor focality is not an independent prognostic factor of biochemical outcome in radical prostatectomy patients. | no |
21,882,211 | Is increased expression of putative cancer stem cell markers in primary prostate cancer associated with progression of bone metastases? | {
"contexts": [
"A number of putative stem cell markers have been associated with aggressiveness of prostate cancer, including alpha 2 and alpha 6 integrin and c-met. The study aimed to test the hypothesis that the development of bone metastasis correlates with the proportion of prostate cancer stem cell-like cel... | It can be concluded that percentage of stem cell-like prostate cancer cells has a prognostic impact especially on the risk of metastatic bone progression. | yes |
21,872,446 | Is epidermal growth factor-induced matrix metalloproteinase-1 expression negatively regulated by p38 MAPK in human skin fibroblasts? | {
"contexts": [
"Many extracellular stimuli, including epidermal growth factor (EGF), are known to induce MMP-1 expression. Recently, several reports have shown that ERK activity plays an important role in EGF-induced MMP-1 expression. However, EGF is also known to activate many signaling pathways in addition to ... | Our results indicate that EGF-induced MMP-1 expression is differentially regulated by the JNK, p38 MAPK, and PI3K/Akt pathways, and suggest that p38 MAPK negatively regulates EGF-induced MMP-1 expression by suppressing the activations of ERK and JNK. | yes |
21,872,447 | Does human catestatin enhance migration and proliferation of normal human epidermal keratinocytes? | {
"contexts": [
"Skin-derived antimicrobial peptides, such as human β-defensins and cathelicidins, actively contribute to host defense by inactivating microorganisms. Catestatin, a neuroendocrine peptide that affects human autonomic functions, has recently been detected in keratinocytes upon injury/infection wher... | Besides inhibiting the growth of skin pathogens, catestatin peptides may also contribute to cutaneous wound closure by enhancing keratinocyte migration and proliferation at the wound site. | yes |
21,872,442 | Does analysis of efficacy and side effects in CATIE demonstrate drug response subgroups and potential for personalized medicine? | {
"contexts": [
"This study aims to improve understanding of antipsychotic non/response and assess the potential for personalized schizophrenia treatment.",
"We used data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). Efficacy measures included the Positive and Negative Syndrome... | Our results demonstrate the existence of subgroups of patients characterized by distinct patterns of drug response. Further, findings suggest that patients who experience a poor response to one drug may be an optimal responder to another antipsychotic. Taken together these findings demonstrate the potential to personal... | yes |
21,899,552 | Does leaf extract of Rhus verniciflua Stokes protect dopaminergic neuronal cells in a rotenone model of Parkinson 's disease? | {
"contexts": [
"The present study investigated the neuroprotective effects of Rhus verniciflua Stokes (RVS) leaf extract on rotenone-induced apoptosis in human dopaminergic cells, SH-SY5Y.",
"Cells were pretreated with RVS extract for 1 h then treated with vehicle or rotenone for 24 h. Cell viability, cell c... | These findings demonstrate that RVS protects SH-SY5Y cells against rotenone-induced injury and suggest that RVS may have potential therapeutic value for neurodegenerative disease associated with oxidative stress. | yes |
21,898,119 | Do use of parenteral colistin for the treatment of multiresistant Gram-negative organisms in major burn patients in South Korea? | {
"contexts": [
"To assess the therapeutic effect and toxicity of intravenous colistin in the treatment of multidrug-resistant (MDR) Gram-negative bacteria in patients with severe burns.",
"The medical records of 930 patients admitted to the Burn Intensive Care Unit (ICU) at Hallym University Hangang Sacred H... | Colistin appears to be a relatively safe and effective treatment for major burn patients with infections caused by MDR Gram-negative bacteria when no other drug is available. Additionally, we found no statistically significant impairment of creatinine levels. | yes |
21,901,119 | Does high tumour cannabinoid CB1 receptor immunoreactivity negatively impact disease-specific survival in stage II microsatellite stable colorectal cancer? | {
"contexts": [
"There is good evidence in the literature that the cannabinoid system is disturbed in colorectal cancer. In the present study, we have investigated whether CB(1) receptor immunoreactive intensity (CB(1)IR intensity) is associated with disease severity and outcome.",
"CB(1)IR was assessed in fo... | The level of CB(1) receptor expression in colorectal cancer is associated with the tumour grade in a manner dependent upon the degree of CpG hypermethylation. A high CB(1)IR is indicative of a poorer prognosis in stage II microsatellite stable tumour patients. | yes |
21,887,101 | Do outcomes of 23-gauge pars plana vitrectomy and internal limiting membrane peeling with brilliant blue in macular hole? | {
"contexts": [
"The evaluation of anatomic and visual outcomes in macular hole cases treated with internal limiting membrane (ILM) peeling, brilliant blue (BB), and 23-gauge pars plana vitrectomy (PPV).",
"Fifty eyes of 48 patients who presented between July 2007 and December 2009 with the diagnosis of stage... | PPV and ILM peeling in stage 2, 3, and 4 macular hole cases provide successful anatomic outcomes, however, in delayed cases, due to photoreceptor loss, it has no effect on functional recovery. BB, used for clarity of ILM, may be beneficial due to its low retinal toxicity. | yes |
21,887,100 | Do reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma? | {
"contexts": [
"Laser speckle flowgraphy (LSFG) enables noninvasive quantification of the retinal circulation in glaucoma patients. In this study, we tested the intrasession reproducibility of LSFG-NAVI, a modified LSFG technique.",
"Sixty-five eyes from 33 subjects (male (M):female (F) = 17:16) with a mean ... | LSFG-NAVI showed favorable reproducibility in evaluation of retinal circulation of glaucoma patients, particularly in the optic disk and choroid. | yes |
21,871,300 | Do previous head and neck cancers portend poor prognoses in lung cancer patients? | {
"contexts": [
"Although a common clinical pairing, the epidemiology and prognosis of lung cancer (LC) after head and neck cancer (HNC) is not well described.",
"Data from the database of the Surveillance, Epidemiology and End Results (SEER) Program were used to study the epidemiology and survival of patient... | Of patients who survive LC or HNC, the latter are much more likely to develop a new pulmonary malignancy. Lung cancers that develop after HNC have a poor prognosis. This phenomenon is not explained by misclassified metastases, because histologically discordant cases behave just as poorly. Enhanced surveillance and chem... | yes |
21,881,971 | Does intravenous injection of endogenous microbial components abrogate DSS-induced colitis? | {
"contexts": [
"The etiology of inflammatory bowel diseases (IBD) is largely unknown, but appears to be perpetuated by uncontrolled responses to antigenic components of the endogenous flora. Tolerance to antigenic stimulation can be achieved by exposure to a given antigen in high amounts (high dose tolerance). C... | Pretreatment with high amount of endogenous bacterial components has a profound tolerogenic effect on the systemic and mucosal immune responses resulting in reduced intestinal inflammation and abrogates colitis-induced weight loss. | yes |
21,885,492 | Does fCRL3 -169C/C genotype is associate with anti-citrullinated protein antibody-positive rheumatoid arthritis and with radiographic progression? | {
"contexts": [
"Studies of Caucasian populations have shown conflicting results concerning the association between a promoter polymorphism -169T>C of the Fc receptor-like 3 (FCRL3) gene and rheumatoid arthritis (RA). It is unknown whether FCRL3 is associated with autoantibody status and disease severity. We inve... | The promoter polymorphism of FCRL3 was associated with autoantibody-positive RA. Despite the low number of patients, the C/C genotype of the FCRL3 polymorphism consistently and independently predicted radiographic progression. These findings suggest that FCRL3 is involved in both disease susceptibility and progression. | yes |
21,885,495 | Is undertreatment of disease activity in systemic lupus erythematosus patients with endstage renal failure associated with increased all-cause mortality? | {
"contexts": [
"In a cohort of systemic lupus erythematosus (SLE) patients with endstage renal failure, to evaluate whether continuing rheumatology followup visits and immunosuppressive therapy after starting renal replacement were associated with increased survival.",
"We identified all SLE patients over 21... | Active disease in patients with SLE undergoing renal replacement therapy may be underrecognized and undertreated, leading to increased mortality. | yes |
21,872,953 | Does endorectal balloon reduce anorectal doses in post-prostatectomy intensity-modulated radiotherapy? | {
"contexts": [
"To investigate the effect of an endorectal balloon (ERB) on anal wall (Awall) and rectal wall (Rwall) doses in high-dose post-prostatectomy intensity-modulated radiotherapy (IMRT).",
"For 20 patients, referred for salvage IMRT after prostatectomy for prostate cancer, two planning CT-scans wer... | ERB application significantly reduces Awall and to a lesser degree Rwall doses in high-dose post-prostatectomy IMRT. | yes |
21,893,118 | Do variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer? | {
"contexts": [
"Expression of the netrin-1 dependence receptor UNC5C is reduced in many colorectal tumors; mice with the UNC5C mutations have increased progression of intestinal tumors. We investigated whether specific variants in UNC5C increase risk of colorectal cancer (CRC).",
"We analyzed the sequence of... | Inherited mutations in UNC5C prevent apoptosis and increase risk of CRC. | yes |
21,873,690 | Is enthesis erosion in spondyloarthritis a persistent structural lesion? | {
"contexts": [
"To evaluate the ability of ultrasound (US) to detect the presence and change of Achilles erosions in spondyloarthritis (SpA).",
"A blind prospective two-dimensional (2D) and three-dimensional (3D) US study of Achilles enthesis erosions in early SpA was undertaken. US examinations were perform... | US examination of Achilles erosions is reliable and sensitive to change. An association was found between Achilles erosions and objective activity-based measurements of SpA outcomes. | no |
21,894,483 | Are cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy ameliorated by physical activity? | {
"contexts": [
"Studies in women with breast cancer, and in animal models, have demonstrated that chemotherapy can have a negative impact on cognitive function. Which chemotherapy agents cause problems with cognition and the aetiology of the impairment is unknown. Furthermore, there is no proven treatment.",
... | The combination 5FU/OX had a significant impact on cognition. However, rats treated with 5FU/OX that exercised post chemotherapy had improved cognition relative to non-exercising rats. This suggests that physical activity may prove useful in ameliorating the cognitive impairments induced by 5FU/OX. | yes |
21,901,362 | Does resilience in infertile couples act as a protective factor against infertility-specific distress and impaired quality of life? | {
"contexts": [
"Our hypothesis was that resilience (=psychosocial stress-resistance) reduces infertility-specific distress and maintains quality of life of infertile couples.",
"Questionnaire data of WHO Quality of Life assessment (WHOQOL; domains: 'physical', 'psychological', 'social relationships' and 'env... | For infertile couples, resilience can be considered as an unspecific protective factor against infertility-specific distress and impaired quality of life. When offering counselling to involuntarily childless couples, awareness should be raised for resilience as a couple's resource and a "generic" factor of coping. | yes |
21,883,629 | Do program director perceived factors for an enhanced advanced education program in prosthodontics recall system? | {
"contexts": [
"A survey study of program directors in Advanced Education Programs in Prosthodontics (AEPPs) was conducted to determine the barriers to and factors that can lead to an enhanced patient-centered recall system.",
"Surveys were sent to AEPP directors across the United States to assess their prog... | Prosthodontic program directors perceived their program's recall system could be improved. If solutions to the most common hindrances were found, almost all program directors desired to establish a recall system within their AEPP. Therefore, a pilot recall system could be valuable in identifying these solutions in esta... | yes |
21,881,319 | Is ki-67 labeling index associated with recurrence after segmentectomy under video-assisted thoracoscopic surgery in stage I non-small cell lung cancer? | {
"contexts": [
"Video-assisted thoracoscopic surgery (VATS) segmentectomy for small or early stage non-small cell lung cancer (NSCLC) remains controversial. Here, we investigated the clinical importance of predicting recurrence by Ki-67 in VATS segmentectomy for stage I NSCLC.",
"In a retrospective study, 44... | Ki-67 LI after VATS segmentectomy was a prognostic factor of disease-free survival in NSCLC and the treatment of choice for patients with positive LI may be considered, in addition to adjuvant chemotherapy, or lobectomy. | yes |
21,898,707 | Is tools for translational neuroscience : PTSD associated with heightened fear responses using acoustic startle but not skin conductance measures? | {
"contexts": [
"Posttraumatic stress disorder (PTSD) patients show heightened fear responses to trauma reminders and an inability to inhibit fear in the presence of safety reminders. Brain imaging studies suggest that this is in part due to amygdala over-reactivity as well as deficient top-down cortical inhibiti... | Replicating earlier studies, we showed increased FPS in PTSD participants. However, although SCR was a good measure of differential conditioning, it did not differentiate between PTSD groups. These data suggest that FPS may be a useful tool for translational research. | yes |
21,897,293 | Is continuing smoking between adolescence and young adulthood associated with higher arterial stiffness in young adults : the Northern Ireland Young Hearts Project? | {
"contexts": [
"To investigate the associations between smoking in adolescence and adulthood, and changes in smoking behaviour between these age periods, with arterial stiffness in young adults; and whether any such associations could be explained by concomitant smoking-related levels of inflammation and endothe... | Starting to smoke in adolescence and continuing to do so up to young adulthood is adversely associated with aortic stiffness. The continuing smoking-related aortic stiffness was not explained by concomitant higher inflammation and endothelial dysfunction. Prevention of smoking should target the young to prevent arteria... | yes |
21,897,294 | Does atorvastatin reduce sympathetic activity in patients with chronic kidney disease? | {
"contexts": [
"Hypertensive chronic kidney disease (CKD) patients often have sympathetic hyperactivity, which appears to contribute to the pathogenesis of hypertension and cardiovascular organ damage. Experimental studies and some clinical studies have shown that statin therapy can reduce central sympathetic ac... | Atorvastatin has a further sympatholytic effect in CKD patients, who are on chronic aliskiren, which is independent of blood pressure and heart rate. | yes |
21,871,748 | Is the mRNA of claudins expressed in the endolymphatic sac epithelia? | {
"contexts": [
"Claudins are a family of membrane proteins which localize to tight junctions (TJs). Recent studies have shown that claudins can form pores for ions in the TJs and regulate the permeability of epithelial paracellular ion transport. The endolymphatic sac (ES) is a part of the inner ear, absorbing t... | We demonstrated mRNA expression of multiple claudins in the rat ES epithelia. These results in the ES epithelia were consistent with a role of claudins in paracellular ion transport. | yes |
21,873,734 | Does the orphan receptor TR3 suppress intestinal tumorigenesis in mice by downregulating Wnt signalling? | {
"contexts": [
"Wnt signalling is involved in cellular homeostasis and development. Dysregulation of the Wnt signalling pathway has been linked to colorectal cancer. The orphan nuclear receptor TR3 plays important roles in proliferation and apoptosis. In this study, we investigated how TR3 suppresses intestinal ... | TR3 is a negative regulator of Wnt signalling and thus significantly suppresses intestinal tumorigenesis in Apc(min/+) mice. This inhibitory effect of TR3 may be paradoxically overcome through phosphorylation by GSK3β in clinical colorectal cancers. | yes |
21,887,289 | Do glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin? | {
"contexts": [
"Recent meta-analyses of genome-wide association studies revealed new genetic loci associated with fasting glycemia. For several of these loci, the mechanism of action in glucose homeostasis is unclear. The objective of the study was to establish metabolic phenotypes for these genetic variants to ... | By examining parameters of glucose-stimulated proinsulin-to-insulin conversion during an OGTT, we show that the SNP in ADCY5 is implicated in defective proinsulin-to-insulin conversion. In addition, we confirmed previous findings on the role of a genetic variant in MADD on proinsulin-to-insulin conversion. These effect... | yes |
21,885,513 | Is the OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Score ( PsAMRIS ) reliable and sensitive to change : results from an OMERACT workshop? | {
"contexts": [
"The aim of this multireader exercise was to assess the reliability and sensitivity to change of the psoriatic arthritis magnetic resonance imaging score (PsAMRIS) in PsA patients followed for 1 year.",
"MRI was acquired from 12 patients with PsA before initiation of treatment and after 12 mon... | This multireader exercise, performed under standardized conditions, confirmed PsAMRIS to have high interobserver and intraobserver reliability for hand PsA. Measures of inflammation were sensitive to change, implying that PsAMRIS may be a valuable tool for monitoring change in inflammation during PsA clinical trials. | yes |
21,884,675 | Is atrial-selective inhibition of sodium-channel current by Wenxin Keli effective in suppressing atrial fibrillation? | {
"contexts": [
"Wenxin Keli is a Chinese herb extract reported to be of benefit in the treatment of cardiac arrhythmias, cardiac inflammation, and heart failure.",
"We evaluated the electrophysiologic effects of Wenxin Keli in isolated canine arterially perfused right atrial preparations with a rim of right ... | Wenxin Keli produces atrial-selective depression of I(Na)-dependent parameters in canine isolated coronary-perfused preparations via a unique mechanism and is effective in suppressing AF and preventing its induction, with minimal effects on the ventricular electrophysiology. | yes |
21,883,135 | Does urinary placental growth factor differentiate the hypertensive disorders of pregnancy? | {
"contexts": [
" To evaluate the discriminating capacity of urinary placental growth factor (uPlGF) for different hypertensive diseases of pregnancy during the third trimester.",
" A prospective descriptive case-control study conducted in an urban tertiary referral hospital and district general hospital, S... | Urinary placental growth factor is a simple non-invasive test, which is discriminatory for pre-eclampsia in the third trimester of pregnancy. Results from this study indicate that it may be discriminatory for hypertension related to placental dysfunction (pre-eclampsia and gestational hypertension) when compared with... | yes |
21,896,322 | Does spasmolytic activity of Rosmarinus officinalis L. involve calcium channels in the guinea pig ileum? | {
"contexts": [
"Rosmarinus officinalis L. is a plant used around the world for its properties to cure pain in several conditions, such as arthritic and abdominal pain or as an antispasmodic; however, there are no scientific studies demonstrating its spasmolytic activity. Therefore, the aim of the present study w... | The present results reinforce the use of Rosmarinus officinalis as antispasmodic in folk medicine. Moreover, it is demonstrated the involvement of calcium channels in this activity, but not the participation of nicotinic receptors, prostaglandins or nitric oxide. | yes |
21,897,333 | Are genes linked to energy metabolism and immunoregulatory mechanisms associated with subcutaneous adipose tissue distribution in HIV-infected men? | {
"contexts": [
"Genetic studies may help explain abnormalities of fat distribution in HIV-infected patients treated with antiretroviral therapy (ARV).",
"Subcutaneous adipose tissue (SAT) volume measured by MRI in the leg, the lower trunk, the upper trunk, and the arm was examined in 192 HIV-infected White m... | Our results are limited by the small sample size and replication is needed; however, this genomic scan uncovered new genes associated with metabolism and inflammatory pathways that may affect SAT volume in ARV-treated HIV-infected patients. | yes |
21,875,287 | Does miR-138 suppress expression of hypoxia-inducible factor 1α ( HIF-1α ) in clear cell renal cell carcinoma 786-O cells? | {
"contexts": [
"Hypoxia-inducible factor-1alpha (HIF-1a) is widely considered to be one of the key regulators in cancer cells. Here, we investigated a microRNA regulating expression of HIF-1a and explored its functions in clear cell renal cell carcinoma (ccRCC) cells.",
"Western blot and reporter assays were... | miR-138 could inhibit the expression of HIF-1a and regulate the apoptosis and migration of ccRCC cells. | yes |
21,875,281 | Does ultrasound operators ' confidence influence diagnosis of ovarian tumors - a study in China? | {
"contexts": [
"To assess the effect of ultrasound operators' confidence in diagnosis of ovarian cancer, and the factors influencing diagnostic accuracy.",
"Ultrasound images of selected ovarian cancers and controls were evaluated by 8 sinologists who were instructed to diagnose and classify lesions into ben... | Our study showed that level of confidence is positively associated with diagnostic performance, and the accuracy is greatly influenced by working experience and confidence score. | yes |
21,889,243 | Does primary stability and strain distribution of cementless hip stem as a function of implant design? | {
"contexts": [
"Short stem prostheses have been developed to preserve the femoral bone stock. The purpose of this study was to evaluate the stress-shielding effect in the proximal femur as well as the micromotion between bone and implant as a measure of primary stability for a new short stem in comparison to a c... | The new short stem prosthesis displayed reduced stress shielding and comparable primary stability to an established short stem and a conventional shaft design. Shortening the stem did not negatively influence primary stability. The clinical implications of these findings remain to be proven. | yes |
21,873,159 | Does oncogenic KRAS regulate miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells? | {
"contexts": [
"Oncogenic KRAS plays several key roles in a three-dimensional (3D) colonic-crypt model. However, miRNA expression regulated by oncogenic KRAS in this model is still elusive.",
"The differential expression of 105 cancer-related microRNAs was examined and compared in HCT116 cells and HKe3 cells... | Oncogenic KRAS regulates 3D-specific molecules, possibly being associated with colorectal tumor development in vivo. | yes |
21,900,022 | Does extracorporeal membrane oxygenation support improve survival of patients with Hantavirus cardiopulmonary syndrome refractory to medical treatment? | {
"contexts": [
"The aim of the study was to evaluate the outcome of extracorporeal membrane oxygenation (ECMO) support in Hantavirus cardiopulmonary syndrome (HCPS) patients with a predicted mortality of 100%, and the complications associated with this treatment modality and different cannulation techniques.",
... | Two-thirds of 51 HCPS patients with a predicted mortality of 100%, who were supported with ECMO, survived and recovered completely. Survival was significantly higher in the second half of the study. Complications associated with both types of femoral cannulation were associated with a trend toward decreased survival, w... | yes |
21,884,021 | Does atorvastatin inhibit homocysteine-induced endoplasmic reticulum stress through activation of AMP-activated protein kinase? | {
"contexts": [
"Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a fundamental role in the initiation and development of atherosclerosis. Atorvastatin is known to exert pleiotropic effects on cardiovascular system. This study was designed to examine the effect of atorvastatin on homocy... | Atorvastatin inhibits Hcy-induced ER stress both in vitro and in vivo. The protective effect of atorvastatin against Hcy-induced vascular injury is mediated by AMPK activation. | yes |
21,884,022 | Does estrogen receptor beta influence ischemic tolerance in the aged female rat heart? | {
"contexts": [
"Ischemic heart disease remains the leading cause of morbidity and mortality in aged women, with a 2- to 3-fold increase in incidence following menopause. Clinical trials have failed to demonstrate cardioprotective benefit from chronic estrogen (E(2)) replacement therapy, yet protective effects of... | Here, for the first time, our data suggest that acute ERβ activation does not impact ischemic tolerance in the adult or aged female Fischer 344 rat myocardium and this likely due to a lack of detectable ERβ. | no |
21,899,483 | Is yKL-40 protein a marker of asthma? | {
"contexts": [
"Gaining asthma control is still a challenge in a large number of patients. It could be facilitated by using biomarkers indicating the grade of inflammation and correlating with clinical picture. Chitinases and chitinase-like proteins play a role in Th2-type inflammation. Thus, they may be useful ... | YKL-40 seems to be a good marker of asthma. However, its level may not correlate with clinical outcome. | yes |
21,872,252 | Does overexpression of CREG attenuate atherosclerotic endothelium apoptosis via VEGF/PI3K/AKT pathway? | {
"contexts": [
"Cellular repressor of E1A-stimulated genes (CREG) is a homeostasis-modulating gene abundantly expressed in adult artery endothelium. Previous studies have demonstrated a protective effect of CREG against atherosclerosis through prevention of vascular smooth muscle cell apoptosis. However, the rol... | These data demonstrate that CREG plays a critical role in protecting the vascular endothelium from apoptosis, and the protective effort of CREG against ECs apoptosis is through the activation of the VEGF/PI3K/AKT signaling pathway. | yes |
21,880,793 | Does iron modify plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans? | {
"contexts": [
"In autosomal dominant hypophosphatemic rickets (ADHR), fibroblast growth factor 23 (FGF23) resists cleavage, causing increased plasma FGF23 levels. The clinical phenotype includes variable onset during childhood or adulthood and waxing/waning of hypophosphatemia. Delayed onset after puberty in fe... | Low serum iron is associated with elevated FGF23 in ADHR. However, in controls, low serum iron was also associated with elevated C-terminal FGF23, but not intact FGF23, suggesting cleavage maintains homeostasis despite increased FGF23 expression. | yes |
21,871,549 | Do khat ( Catha edulis ) and ethanol co-dependence modulate seizure expression in a pentylenetetrazol seizure model? | {
"contexts": [
"Khat is a plant with psychostimulant properties whose parts, mainly leaves and twigs, are chewed for its euphoriant effects. Khat use and ethanol abuse are increasingly becoming global health concerns especially among many disadvantaged social groups. The present studies were undertaken to invest... | These data suggest that combined moderate to high dose khat and ethanol co-dependence produce a greater deleterious CNS effect than either drug alone. Future studies will address neurochemical effects, in addition to neuroadaptations, resulting from coabuse of these drugs. | yes |
21,888,287 | Are human leukocyte antigens class II genes associated with cancer development in the autoimmune rheumatic diseases? | {
"contexts": [
"To determine the association between HLA class II alleles and the probability of developing cancer in patients with autoimmune rheumatic diseases. MATERIAL AND METHODS; A matched case control study was conducted in which patients with autoimmune rheumatic disease who later developed malignancy (s... | The results suggest an association between HLA class II alleles with the probability of developing a malignant neoplasm in patients suffering from an autoimmune rheumatic disease. | yes |
21,873,550 | Are obesity-associated hepatosteatosis and impairment of glucose homeostasis attenuated by haptoglobin deficiency? | {
"contexts": [
"Haptoglobin (Hp) is upregulated in both inflammation and obesity. The low chronic inflammatory state, caused by massive adipose tissue macrophage (ATM) infiltration found in obesity, and low adiponectin have been implicated in the development of insulin resistance and hepatosteatosis. The aim of ... | We demonstrated that in the absence of Hp, obesity-associated insulin resistance and hepatosteatosis are attenuated, which is associated with reduced ATM content, increased plasma adiponectin, and higher WAT insulin sensitivity. | yes |
21,883,860 | Does bilateral pudendal afferent stimulation improve bladder emptying in rats with urinary retention? | {
"contexts": [
"To determine whether bilateral electrical stimulation (BiES) of the transected pudendal sensory nerves could further enhance the voiding efficiency beyond that produced by unilateral electrical stimulation (UniES) of transected pudendal afferents in rats with urinary retention.",
"The efficie... | The results of the present study are consistent with an essential role for pudendal sensory feedback in efficient bladder emptying, and unilateral and bilateral electrical activation of pudendal nerve afferents are equally efficient in improving bladder emptying in an animal model of urinary retention. This could provi... | yes |
21,876,856 | Does the Model for End-stage Liver Disease accurately predict 90-day liver transplant wait-list mortality in Atlantic Canada? | {
"contexts": [
"To determine the generalizability of the predictions for 90-day mortality generated by Model for End-stage Liver Disease (MELD) and the serum sodium augmented MELD (MELDNa) to Atlantic Canadian adults with end-stage liver disease awaiting liver transplantation (LT).",
"The predictive accuracy... | Both the MELD and the MELDNa accurately predicted the occurrence of 90-day wait-list mortality in the study cohort and, therefore, are generalizable to Atlantic Canadians with end-stage liver disease awaiting LT. | yes |
21,900,188 | Is right ventricular failure in idiopathic pulmonary arterial hypertension associated with inefficient myocardial oxygen utilization? | {
"contexts": [
"In idiopathic pulmonary arterial hypertension (IPAH), increased right ventricular (RV) power is required to maintain cardiac output. For this, RV O2 consumption (MVO2) must increase by augmentation of O2 supply and/or improvement of mechanical efficiency-ratio of power output to MVO2. In IPAH wit... | RV failure in IPAH was associated with reduced mechanical efficiency that was partially explained by RV mechanical dysfunction but not by a metabolic shift. | yes |
21,871,098 | Does calcium spark in the intact gerbil spiral modiolar artery? | {
"contexts": [
"Calcium sparks are ryanodine receptor mediated transient calcium signals that have been shown to hyperpolarize the membrane potential by activating large conductance calcium activated potassium (BK) channels in vascular smooth muscle cells. Along with voltage-dependent calcium channels, they form... | This is the first characterization of calcium sparks in smooth muscle cells of the spiral modiolar artery. The results suggest that calcium sparks may regulate the diameter of the spiral modiolar artery and cochlear blood flow. | yes |
21,885,908 | Does pressure pain threshold testing demonstrate predictive ability in people with acute whiplash? | {
"contexts": [
"Longitudinal cohort study.",
"To determine whether pressure pain threshold (PPT), tested at 2 standardized sites, could provide additional prognostic ability to predict short-term outcomes in people with acute whiplash, after controlling for age, sex, and baseline pain intensity.",
"PPT m... | Sex, pain intensity, and PPT measured at a site distal to the injury were the most parsimonious set of predictors of short-term neck-related disability score, and represented promising additions to assessment of traumatic neck pain. Neither age nor PPT at the local site was able to explain significant variance beyond t... | yes |
21,897,868 | Does genotyping of Capreolus pygargus fossil DNA from Denisova cave reveal phylogenetic relationships between ancient and modern populations? | {
"contexts": [
"The extant roe deer (Capreolus Gray, 1821) includes two species: the European roe deer (C. capreolus) and the Siberian roe deer (C. pygargus) that are distinguished by morphological and karyotypical differences. The Siberian roe deer occupies a vast area of Asia and is considerably less studied t... | Analysis of mitochondrial DNA from both ancient and modern samples of Siberian roe deer shed new light on understanding the evolutionary history of roe deer. Our data indicate that during the last 50,000 years multiple replacements of populations of the Siberian roe deer took place in the Altai Mountains correlating wi... | yes |
21,897,861 | Is betacellulin-induced beta cell proliferation and regeneration mediated by activation of ErbB-1 and ErbB-2 receptors? | {
"contexts": [
"Betacellulin (BTC), a member of the epidermal growth factor family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells. Growth-promoting actions of BTC are mediated by epidermal growth factor receptors (ErbBs), namely ErbB-1, ErbB-2, ErbB-3 and Er... | These results suggest that BTC exerts proliferative activity on beta cells through the activation of ErbB-1 and ErbB-2 receptors, which may increase IRS-2 expression, contributing to the regeneration of beta cells. | yes |
21,875,346 | Is altered expression of the gap junction protein connexin43 associated with papillary thyroid carcinomas when compared with other noncancer pathologies of the thyroid? | {
"contexts": [
"Gap junctions are membrane structures composed of connexins (Cx) that allow diffusion of small molecules between cells. They are involved in tissue homeostasis, and various organ dysfunctions have been associated with gap junction defects. To verify their possible involvement in thyroid pathologi... | These results show that aberrations of Cx43 expression are associated with thyroid papillary carcinoma. | yes |
21,899,546 | Does kIOM-79 inhibit aldose reductase activity and cataractogenesis in Zucker diabetic fatty rats? | {
"contexts": [
"KIOM-79, a combination of four plant extracts, has a preventive effect on diabetic nephropathy and retinopathy in diabetic animal models. In this study, we have investigated the inhibitory effects of KIOM-79 on diabetic cataractogenesis.",
"We evaluated aldose reductase activity during catara... | These observations suggested that KIOM-79 was useful against the treatment of diabetic cataractogenesis. | yes |
21,899,547 | Does acteoside inhibit melanogenesis in B16F10 cells through ERK activation and tyrosinase down-regulation? | {
"contexts": [
"Acteoside is a phenylpropanoid glycoside extracted from the leaves of Rehmannia glutinosa that displays various biological activities. In this study, we tested the effects of acteoside on tyrosinase activity and melanin biosynthesis in B16F10 melanoma cells. We also explored molecular mechanisms ... | Acteoside decreased tyrosinase activity and melanin biosynthesis in B16F10 cells by activating ERK signalling, which down-regulated MITF, tyrosinase and TRP-1 production. | yes |
21,876,771 | Does h5N1 whole-virus vaccine induce neutralizing antibodies in humans which are protective in a mouse passive transfer model? | {
"contexts": [
"Vero cell culture-derived whole-virus H5N1 vaccines have been extensively tested in clinical trials and consistently demonstrated to be safe and immunogenic; however, clinical efficacy is difficult to evaluate in the absence of wide-spread human disease. A lethal mouse model has been utilized whi... | These data underpin the confidence that the Vero cell culture-derived, whole-virus H5N1 vaccine will be effective in a pandemic situation and support the use of neutralizing serum antibody titers as a correlate of protection for H5N1 vaccines. | yes |
21,876,773 | Is iQGAP1 a novel CXCR2-interacting protein and essential component of the `` chemosynapse ''? | {
"contexts": [
"Chemotaxis is essential for a number of physiological processes including leukocyte recruitment. Chemokines initiate intracellular signaling pathways necessary for chemotaxis through binding seven transmembrane G protein-couple receptors. Little is known about the proteins that interact with the ... | Our studies indicate that IQGAP1 is a novel essential component of the CXCR2 "chemosynapse". | yes |
21,893,345 | Are inexperienced nurses and doctors equally efficient in managing the airway in a manikin model? | {
"contexts": [
"The aim of the present study was to investigate whether minimally trained medical and nursing school graduates would be equally efficient in placing a laryngeal mask airway (LMA) and in intubating the trachea with the Macintosh blade or a videolaryngoscope in a manikin model. Airway management is... | Nurses are as efficient as physicians in managing the airway safely and adequately with the 3 different techniques in manikins. | yes |
21,887,116 | Is an eight-week yoga intervention associated with improvements in pain , psychological functioning and mindfulness , and changes in cortisol levels in women with fibromyalgia? | {
"contexts": [
"Fibromyalgia (FM) is a chronic condition characterized by widespread musculoskeletal pain, fatigue, depression, and hypocortisolism. To date, published studies have not investigated the effects of yoga on cortisol in FM. This pilot study used a time series design to evaluate pain, psychological v... | The results suggest that a yoga intervention may reduce pain and catastrophizing, increase acceptance and mindfulness, and alter total cortisol levels in women with FM. The changes in mindfulness and cortisol levels may provide preliminary evidence for mechanisms of a yoga program for women with FM. Future studies shou... | yes |
21,896,238 | Does dissociation mediate the relationship between childhood trauma and hallucination-proneness? | {
"contexts": [
"It has been proposed that the relationship between childhood trauma and hallucinations can be explained by dissociative processes. The present study examined whether the effect of childhood trauma on hallucination-proneness is mediated by dissociative tendencies. In addition, the influence of dis... | These results are consistent with dissociative accounts of the trauma-hallucinations link. Dissociation, however, does not affect reality discrimination. Future research should examine whether other cognitive processes associated with both dissociative states and hallucinations (e.g. deficits in cognitive inhibition) m... | yes |
21,892,584 | Is [ Blood glucose levels in the first 24 hours of admission a risk factor for mortality in critical care patients ]? | {
"contexts": [
"Glycemic alterations are known as a risk condition of death in several diseases, such as ischemic cardiovascular and neurological disorders. The fact that its tight control under narrow normality levels decreases mortality and morbidity have led to further studies seeking to confirm the results a... | A total of 2,165 of the 2,554 admitted patients during the study period were included (96.5%). Exclusion criteria were absence of plasma glucose determinations. In the bivariate analysis, first and mean glucose blood levels showed significant differences in mortality rates in absolute figures and also when data were cl... | no |
21,892,583 | Does mineral and/or milk supplementation of fruit beverages help in the prevention of H2O2-induced oxidative stress in Caco-2 cells? | {
"contexts": [
"Fruit beverages are commonly supplemented with milk, vitamins and/or minerals in order to improve their healthy effects by providing some bioactive components that can act additively or synergistically against oxidative stress.",
"To test whether iron, zinc, and milk added to fruit beverages ... | Fruit beverages prevented the deleterious effect of H2O2 on cell viability, with almost all samples reaching control basal levels. Only independent iron or zinc supplementation with/without milk exerted positive effects upon GSH-Rd activity. Both minerals with milk, afforded improved preservation of GSH-Px activity. Al... | yes |
21,872,847 | Does withdrawal from chronic nicotine exposure alter dopamine signaling dynamics in the nucleus accumbens? | {
"contexts": [
"Unaided attempts to quit smoking commonly fail during the first 2 weeks of the nicotine withdrawal syndrome. Alterations in dopamine (DA) signaling correlate with withdrawal from chronic nicotine exposure, but those changes have not been well-characterized.",
"Mice were administered nicotine ... | The relative increase in the sensitivity of DA release to phasic stimulation suggests an increase in the signal-to-noise relationship of DA signaling during the withdrawal period. Therefore, the DA signal produced by acute nicotine re-exposure produces a DA response that might reinforce relapse to drug use (i.e., smoki... | yes |
21,872,848 | Does early-life forebrain glucocorticoid receptor overexpression increase anxiety behavior and cocaine sensitization? | {
"contexts": [
"Genetic factors and early-life adversity are critical in the etiology of mood disorders and substance abuse. Because of their role in the transduction of stress responses, glucocorticoid hormones and their receptors could serve as both genetic factors and mediators of environmental influences. We... | Transient overexpression of GR early in life is both necessary and sufficient for inducing transcriptome-wide changes in the brain and producing a lifelong increase in vulnerability to anxiety and drugs of abuse. | yes |
21,880,315 | Is myeloperoxidase , but not oxidized LDL , associated with leisure-time physical activity : results from the MONICA/KORA Augsburg Studies 1984-1995? | {
"contexts": [
"Oxidative stress-induced cell damage contributes to several chronic conditions such as cardiovascular disease, but only very few population-based studies have examined the influence of regular physical activity (PA) on oxidative stress.",
"1820 men and women aged 35-74 years were randomly dra... | These data indicate that regular leisure-time PA may reduce MPO concentrations. | yes |
21,898,357 | Does prostaglandin D2 regulate joint inflammation and destruction in murine collagen-induced arthritis? | {
"contexts": [
"Prostaglandin D2 (PGD2) may exert proinflammatory or antiinflammatory effects in different biologic systems. Although this prostanoid and the enzymes responsible for its synthesis are up-regulated by interleukin-1β (IL-1β) in human chondrocytes in vitro, the role of PGD2 in arthritis remains uncl... | Our findings indicate that PGD2 is produced in articular tissue during the development of CIA and plays an antiinflammatory role, acting through the DP1 receptor. | yes |
21,892,586 | Does [ Consumption of the probiotic Lactobacillus planctarum CECT 7315/7316 improve general health in the elderly subjects ]? | {
"contexts": [
"Ageing induces changes in gut microbiota that may affect the quality of life. In this work we analyze the effect of Lactobacillus plantarum CECT 7315/7316 on the regulation of intestinal transit and on nutritional status.",
"We carried out a double-blind, randomized and controlled by placebo ... | Consumption of functional foods containing L. plantarum CECT 7315/7316 improves the quality of life in elderly subjects. | yes |
21,900,721 | Does abacavir coadministration interfere with the suppressive activity of ribavirin in an HCV replicon system? | {
"contexts": [
"HCV is a major cause of morbidity and mortality in HIV-coinfected patients. Several observational studies have suggested that HCV response to pegylated interferon and ribavirin is lower in HIV-coinfected patients treated with abacavir. It has been postulated that abacavir could compete with ribav... | In a subgenomic HCV RNA replicon system, the antiviral effect of ribavirin was not modified by the addition of abacavir, tenofovir or lamivudine. | no |
21,884,594 | Does retrotransposon-centered analysis of piRNA targeting show a shift from active to passive retrotransposon transcription in developing mouse testes? | {
"contexts": [
"Piwi-associated RNAs (piRNAs) bind transcripts from retrotransposable elements (RTE) in mouse germline cells and seemingly act as guides for genomic methylation, thereby repressing the activity of RTEs. It is currently unknown if and how Piwi proteins distinguish RTE transcripts from other cellul... | Reanalyzing published piRNA sequences and taking into account the features of individual RTE loci provide novel insight into the activity of RTEs during development. The obtained results are consistent with some degree of proportionality between what transcripts become substrates for Piwi protein complexes and the leve... | yes |
21,900,086 | Does therapeutic inhibition of miR-208a improve cardiac function and survival during heart failure? | {
"contexts": [
"Diastolic dysfunction in response to hypertrophy is a major clinical syndrome with few therapeutic options. MicroRNAs act as negative regulators of gene expression by inhibiting translation or promoting degradation of target mRNAs. Previously, we reported that genetic deletion of the cardiac-spec... | These studies indicate the potential of oligonucleotide-based therapies for modulating cardiac miRNAs and validate miR-208 as a potent therapeutic target for the modulation of cardiac function and remodeling during heart disease progression. | yes |
21,882,048 | Is iD4 frequently downregulated and partially hypermethylated in prostate cancer? | {
"contexts": [
"The candidate tumor suppressor ID4 is downregulated in various cancers by DNA hypermethylation. We have performed the first systematic analysis of ID4 expression and methylation in prostate cancer.",
"ID4 mRNA expression was analyzed by quantitative RT-PCR in 47 carcinoma and 13 benign prosta... | ID4 downregulation may contribute to prostate cancer pathogenesis and is often accompanied by DNA hypermethylation. The case of ID4 illustrates exemplarily the limits and pitfalls of techniques for the detection of methylation changes in prostate cancer tissues. | yes |
21,895,809 | Does evaluation of two detection methods of microorganisms in platelet concentrate? | {
"contexts": [
"The performance of a bacterial 16S ribosomal DNA real-time polymerase chain reaction (PCR) assay was evaluated and validated with an automated culture system to determine its use for screening of platelet concentrates (PCs).",
"PCs were spiked with suspensions of Escherichia coli, Serratia ma... | The BacT/ALERT method is more sensitive and should continue to be the gold standard for identifying bacterial contaminations in blood samples. The real-time PCR approach can be used for the screening of PCs for microbial detection before they are released from blood centres or shortly before they are used in blood tran... | yes |
21,873,660 | Is literacy an independent risk factor for vision impairment and poor visual functioning? | {
"contexts": [
"People with limited literacy are at increased risks of chronic systemic conditions. The authors therefore investigated the independent contribution of limited literacy on visual impairment and visual function in a large eye survey in Singapore.",
"The authors undertook a population-based, cro... | Inadequate literacy is independently associated with visual impairment and poorer visual functioning. Interventions that address literacy may help to reduce socioeconomic disparities in visual impairment. | yes |
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