pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
22,890,131 | Do regulatory T cells inhibit CD8 ( + ) T-cell tissue invasion in human skin graft-versus-host reactions? | {
"contexts": [
"Regulatory T cells (Tregs) effectively ameliorate graft-versus-host disease (GVHD). The mechanisms underlying Treg therapeutic effect on GVHD are not fully elucidated. This study investigates whether Treg prevention of GVH tissue damage is associated with blocking CD8 effector T-cell tissue invas... | Preventing effector T-cell tissue invasion is a critical mechanistic event leading to Treg attenuation of GVH tissue damage. This therapeutic effect is associated with a failure of CD8 T cells to increase tissue homing receptors after allo-stimulation, together with a breakdown of interferon-γ-induced chemoattractant e... | yes |
22,878,375 | Is the TERT variant rs2736100 associated with colorectal cancer risk? | {
"contexts": [
"Polymorphic variation at the 5p15.33 (TERT-CLPTM1L) locus is associated with the risk of many cancers but a relationship with colorectal cancer (CRC) risk has yet to be defined.",
"We used data from six genome-wide association studies (GWAS) of CRC, linkage disequilibrium mapping and imputati... | The rs2736100 association demonstrates an influence of variation at 5p15.33 on CRC risk and further evidence that the 5p15.33 (TERT-CLPTM1L) locus has pleiotropic effects (reflecting generic or lineage-specific effects) on cancer risk. | yes |
22,889,314 | Is admission to day stay early parenting program associated with improvements in mental health and infant behaviour : A prospective cohort study? | {
"contexts": [
"Australia's Early Parenting Services support families and intervene early in mental health problems in parents. The Victorian Early Parenting Strategy, a platform for government policy recommended a stronger evidence base for early parenting services. Tweddle Child and Family Health Service (TCFH... | Tweddle DSPs appear to respond effectively to the needs of families presenting with substantial physical and emotional health morbidity and a range of vulnerabilities by treating parental mental health and infant behaviour problems together. DSPs offer important potential benefits for prevention of more serious family ... | yes |
22,885,415 | Does sodium pyruvate reduce hypoxic-ischemic injury to neonatal rat brain? | {
"contexts": [
"Neonatal hypoxia-ischemia (HI) remains a major cause of severe brain damage and is often associated with high mortality and lifelong disability. Immature brains are extremely sensitive to HI, shown as prolonged mitochondrial neuronal death. Sodium pyruvate (SP), a substrate of the tricarboxylic a... | SP protected neonatal brain from hypoxic-ischemic injury through maintaining cerebral metabolism and mitochondrial function. | yes |
22,882,193 | Is nuclear expression of thioredoxin-1 in the invasion front associated with outcome in patients with gallbladder carcinoma? | {
"contexts": [
"Multifunctional redox protein human thioredoxin (TRX-1) is reduced by thioredoxin reductase (TRX-R). The aim of the present study was to examine the distribution of TRX-1 and TRX-R expressions in gallbladder carcinoma (GBC) to clarify their usefulness as prognostic factors after surgical resectio... | TRX-1 nuclear expression in the GBC invasion front is a significant prognostic marker. Patients with both TRX-1 nuclear expression and TRX-R cytoplasmic expression in the tumour invasion front should be observed carefully even if after curative resection. | yes |
22,882,997 | Is population-based analyses of Giardia duodenalis consistent with the clonal assemblage structure? | {
"contexts": [
"Giardia duodenalis is a common protozoan parasite of humans and animals. Genetic characterization of single loci indicates the existence of eight groups called assemblages, which differ in their host distribution. Molecular analyses challenged the idea that G. duodenalis is a strictly clonal dipl... | We conclude that recombination between G. duodenalis assemblages is either very rare or absent. Recombination between genotypes from the same assemblage and genetic exchange between the nuclei of a single cyst needs further investigation. | yes |
22,898,590 | Are mealtime habits and meal provision associated with malnutrition among elderly patients admitted to hospital? | {
"contexts": [
"Large-scale studies performed in hospitals with the validated Mini Nutritional Assessment (MNA) tool are scarce. However, factors associated with malnutrition are important for identifying individuals at risk. The aims of the present study were to estimate the prevalence of malnutrition and to ex... | The risk of malnutrition was high among elderly patients admitted to hospital, whereas the proportion with fully developed malnutrition was lower than expected. A long overnight fast, few eating episodes, and not cooking independently were associated with an increased risk of malnutrition. Knowledge of these factors wh... | yes |
22,902,023 | Does urinary diversion result in marked decreases in proliferation and apoptosis in fetal bladder? | {
"contexts": [
"We sought to determine if bladder cycling is required for remodeling during fetal development.",
"For this study 5 fetal sheep bladders were harvested after 2 weeks of urinary diversion, initiated at approximately 90 days of gestation. Six unoperated sheep bladders of approximately 105 days o... | Cell mitotic activity and coordinated cell death appear to be involved in growth and remodeling, which are activated by the mechanical input that occurs during bladder cycling. Fetal urinary diversion results in a repression of mitotic and apoptotic activity, limiting normal bladder growth and remodeling. | yes |
22,897,944 | Does soluble KIT correlate with clinical outcome in patients with metastatic breast cancer treated with sunitinib? | {
"contexts": [
"Sunitinib inhibits vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors, and stem cell factor receptor (KIT). The ability of soluble (s)KIT, VEGF-A, sVEGFR-2, and sVEGFR-3 to predict clinical outcome was analyzed in 61 patients with previously treated me... | This exploratory analysis suggests that changes in sKIT and possibly VEGF-A early during sunitinib treatment may be predictive of clinical outcome in MBC. | yes |
22,905,134 | Does transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promote non-neurogenic inflammation? | {
"contexts": [
"The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for the role of neurogenic inf... | Our results demonstrate that, although either TRPV1 or TRPA1 activation causes airway neurogenic inflammation, solely TRPA1 activation orchestrates an additional inflammatory response which is not neurogenic. This finding suggests that non-neuronal TRPA1 in the airways is functional and potentially capable of contribut... | yes |
22,899,799 | Does nupr1-aurora kinase A pathway provide protection against metabolic stress-mediated autophagic-associated cell death? | {
"contexts": [
"The limited supply of oxygen and nutrients is thought to result in rigorous selection of cells that will eventually form the tumor.",
"Nupr1 expression pattern was analyzed in human tissue microarray (TMA) and correlated with survival time of the patient. Microarray analysis was conducted on ... | Our data reveal that Nupr1 is involved in a defense mechanism that promotes pancreatic cancer cell survival when exposed to metabolic stress. | yes |
22,884,695 | Does myocardin-A enhance expression of promyogenic genes without depressing telomerase activity in adipose tissue-derived mesenchymal stem cells? | {
"contexts": [
"The stromal compartment of adult adipose tissue consists of mesenchymal stem cells (MSCs) characterized by co-expression of myocardin-A (McA) and telomerase reverse transcriptase (TERT).",
"This study aims at testing the growth and myogenic regenerative properties of adipose tissue-derived MS... | McA and TERT may interplay in promoting promyogenic gene expression and maintaining growth capacity of MSCs. | yes |
22,889,526 | Does a review of physical activity correlate in patients with bipolar disorder? | {
"contexts": [
"Existing studies do suggest that physical activity interventions may be feasible and have a role in promoting mental and physical health in patients with bipolar disorder. The present review evaluates systematically quantitative studies of correlates of physical activity in patients with bipolar ... | The diversity of physical activity measures and subject samples prevented us to perform a meta-analysis. | yes |
22,880,026 | Is uSP22 useful as a novel molecular marker for predicting disease progression and patient prognosis of oral squamous cell carcinoma? | {
"contexts": [
"The significance of ubiquitin-specific protease 22 (USP22) as a potential marker has been growing in the field of oncology. The aim of this study was to investigate the role of USP22 and the association with its potential targets in oral squamous cell carcinoma (OSCC).",
"Immunohistochemistry... | To our knowledge, this is the first study that determines the relationship between USP22 expression and prognosis in OSCC. We found that increased expression of USP22 is associated with poor prognosis in OSCC. USP22 may represent a novel and useful prognostic marker for OSCC. | yes |
22,908,233 | Does estrogen repress hepatocellular carcinoma ( HCC ) growth via inhibiting alternative activation of tumor-associated macrophages ( TAMs )? | {
"contexts": [
"Hepatocarcinoma cancer (HCC) occurs more often in men than in women, and little is known about its underlying molecular mechanisms.",
"We identify that 17β-estradiol (E2) could suppress tumor growth via regulating the polarization of macrophages."
],
"labels": [
"BACKGROUND",
"RES... | Estrogen functions as a suppressor for macrophage alternative activation. | yes |
22,888,907 | Is corky , a gypsy-like retrotransposon differentially transcribed in Quercus suber tissues? | {
"contexts": [
"Transposable elements (TEs) make up a large part of eukaryotic genomes. Due to their repetitive nature and to the fact that they harbour regulatory signals, TEs can be responsible for chromosomal rearrangements, movement of gene sequences and evolution of gene regulation and function. Retrotransp... | These results document that Corky's transcription levels are not constant. Nevertheless, they depend upon the developmental stage, the tissue analysed and the potential occurring events during an individuals' life span. This modulation brought upon by different developmental and environmental influences suggests an inv... | yes |
22,888,908 | Is n-cadherin differentially expressed in histological subtypes of papillary renal cell carcinoma? | {
"contexts": [
"Papillary renal cell carcinoma (RCC) represents a rare tumor, which is divided, based on histological criteria, into two subtypes. In contrast to type I papillary RCC type II papillary RCC shows a worse prognosis. So far, reliable immunohistochemical markers for the distinction of these subtypes ... | Thus N-cadherin represents the first immunhistochemical marker for a clear cut differentiation between papillary RCC type I and type II and could be a target for therapy and diagnostic in the future. | yes |
22,883,636 | Does connexin43 gene transfer reduce ventricular tachycardia susceptibility after myocardial infarction? | {
"contexts": [
"The aim of this study was to evaluate the links between connexin43 (Cx43) expression, myocardial conduction velocity, and ventricular tachycardia in a model of healed myocardial infarction.",
"Post-infarction ventricular arrhythmias frequently cause sudden death. Impaired myocardial conductio... | These data mechanistically link Cx43 expression to slow conduction and arrhythmia susceptibility in the healed scar border zone. Targeted manipulation of Cx43 levels improved conduction velocity and reduced ventricular tachycardia susceptibility. Cx43 gene transfer represents a novel treatment strategy for post-infarct... | yes |
22,892,758 | Does nuclear factor κB activity correlate with the progression and prognosis of pancreatic cancer in a mouse model? | {
"contexts": [
"Constitutive NF-κB activation is considered to play a key role in the aggressive behavior of pancreatic cancer. Although NF-κB in tumors may contribute to aggressive characteristic features via transcription of angiogenesis and invasion-related factors, there is no definitive evidence showing a c... | These results suggested that NF-κB activity is related to expression of its downstream target genes, tumor progression and prognosis in experimental pancreatic cancer model. | yes |
22,889,632 | Does precision of usual food intake estimate according to the percentage of individuals with a second dietary measurement? | {
"contexts": [
"Statistical methods for estimating usual intake require at least two short-term dietary measurements in a subsample of the target population. However, the percentage of individuals with a second dietary measurement (replication rate) may influence the precision of estimates, such as percentiles a... | The precision of the usual intake estimates decreased when low replication rates were used. However, even with different sample sizes, replication rates >40% may not lead to an important loss of precision. | yes |
22,897,663 | Is 11β-hydroxysteroid dehydrogenase type 1 expressed in human sebaceous glands and regulates glucocorticoid-induced lipid synthesis and toll-like receptor 2 expression in SZ95 sebocytes? | {
"contexts": [
"Glucocorticoids (GCs) affect the pathophysiology of sebaceous glands, causing development or exacerbation of acne. The availability of GCs is regulated by isoenzymes of 11β-hydroxysteroid dehydrogenase (11βHSD) at tissue-specific levels. 11βHSD type 1 (HSD11β1) is a reductase, catalysing the conv... | Our results indicate that HSD11β1 plays a key role in the modulation of GC action on sebocytes, including sebum production and TLR2-mediated inflammation, thereby influencing the pathogenesis of acne. | yes |
22,901,763 | Does the Val66Met polymorphism of the BDNF gene influence trigeminal pain-related evoked responses? | {
"contexts": [
"Cortical pain processing is associated with large-scale changes in neuronal connectivity, resulting from neural plasticity phenomena of which brain-derived neurotrophic factor (BDNF) is a central driver. The common single nucleotide polymorphism Val66Met is associated with reduced BDNF activity. ... | BDNF Val66Met polymorphism affects the tPREP N2-P2 amplitude decrement and influences cortical pain processing through neurotrophin-induced neural plasticity, or through a direct BDNF neurotransmitter-like effect. Our findings suggest that upcoming BDNF central agonists might in the future play a role in pain managemen... | yes |
22,903,869 | Are emotion regulation difficulties relevant to persecutory ideation? | {
"contexts": [
"Persecutory delusions are preceded and accompanied by negative emotions, which may be prolonged or even amplified by difficulties in the ability to regulate negative emotions. This study aims to gain insight into emotion regulation difficulties in persecutory ideation.",
"A correlational appr... | Besides the general difficulties in regulating emotion that are common to many clinical disorders and were associated with overall psychopathology, subclinical psychotic symptoms seem to be specifically associated with certain aspects of emotion regulation. Emotion regulation difficulties are likely to contribute to sy... | yes |
22,885,065 | Does loss of Rb cooperate with Ras to drive oncogenic growth in mammalian cells? | {
"contexts": [
"The p53, Rb, and Ras/PI3K pathways are implicated in the development of the majority of human cancers. A number of studies have established that these pathways cooperate at the level of the cell cycle leading to loss of normal proliferative controls. Here we have investigated how these signals in... | We have identified a new role for the Rb family in cell biogenesis and show that, as for other processes associated with tumor development, oncogenic cell growth is dependent on cooperating oncogenes. | yes |
22,902,760 | Do many patients who undergo surgery for colorectal cancer receive surveillance colonoscopies earlier than recommended by guidelines? | {
"contexts": [
"Patients treated with surgery for colorectal cancer (CRC) should undergo colonoscopy examinations 1, 4, and 9 years later, to check for cancer recurrence. We investigated the use patterns of surveillance colonoscopies among Medicare patients.",
"We used the Surveillance, Epidemiology and End ... | Many Medicare enrollees who have undergone curative resection for colorectal cancer undergo surveillance colonoscopy more frequently than recommended by the guidelines. Reducing overuse could free limited resources for appropriate colonoscopy examinations of inadequately screened populations. | yes |
22,886,219 | Does [ Transplantation of autologous myoblasts transfected with VEGF165 improve heart function after myocardial infarction in rabbits ]? | {
"contexts": [
"To determine the improvements of post-infarction heart function after transplantation of autologous skeletal myoblasts transfected with VEGF165 in rabbits.",
"Myocardium infarction was induced in rabbits by left anterior descending coronary artery ligation. At 2 weeks, 1.75×10(7) autologous s... | Autologous skeletal myoblasts transfected with VEGF165 could ameliorate the blood supply in the MI region, and aid recovery of heart function more quickly in post-infarction hearts. This suggests an effective treatment for myocardium infarction. | yes |
22,905,766 | Does gOLPH3 overexpression correlate with tumor progression and poor prognosis in patients with clinically N0 oral tongue cancer? | {
"contexts": [
"Overexpression of GOLPH3 (Golgi phosphoprotein 3, 34 kDa) is associated with the progression of many solid tumor types leading to an unfavorable clinical outcome. We aimed to investigate the clinical significance of GOLPH3 expression in the development and progression of clinically N0 (cN0) oral ... | Our results suggest GOLPH3 overexpression is associated with poor prognosis for cN0 oral tongue cancer patients and may represent a novel and useful prognostic indicator for cN0 oral tongue cancer. | yes |
22,901,285 | Do protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites? | {
"contexts": [
"In ovarian cancer, massive intraperitoneal dissemination is due to exfoliated tumor cells in ascites. Tumor-initiating cells (TICs or cancer stem cells) and cells showing epithelial-mesenchymal-transition (EMT) are particularly implicated. Spontaneous spherical cell aggregates are sometimes obser... | In addition to demonstrating potentially high levels of TICs in ascites, the results suggest that the S-type population is the less tumorigenic one. Nanog(high)/EpCAM(high) samples represent a TIC subset which may be either M- or S-type, and which is separate from the CD44(high)/Oct-4A(high) subset observed only in M-t... | yes |
22,905,734 | Do resection of ictal high-frequency oscillations leads to favorable surgical outcome in pediatric epilepsy? | {
"contexts": [
"Intracranial electroencephalography (EEG) is performed as part of an epilepsy surgery evaluation when noninvasive tests are incongruent or the putative seizure-onset zone is near eloquent cortex. Determining the seizure-onset zone using intracranial EEG has been conventionally based on identifica... | Our study shows that ictal HFOs are commonly found with intracranial EEG in our population largely of children with cortical dysplasia, and have localizing value. The use of ictal HFOs may add more promising information compared to interictal HFOs because of the evidence of ictal propagation and followed by clinical as... | yes |
22,880,714 | Does systemic intermittent parathyroid hormone treatment improve osseointegration of press-fit inserted implants in cancellous bone? | {
"contexts": [
"Intermittent administration of parathyroid hormone (PTH) has an anabolic effect on bone, as confirmed in human osteoporosis studies, distraction osteogenesis, and fracture healing. PTH in rat models leads to improved fixation of implants in low-density bone or screw insertion transcortically.",
... | Intermittent treatment with PTH (1-34) improved histological osseointegration of a prosthesis inserted press-fit at surgery in cancellous bone, with no additional improvement of the initial mechanical fixation at this time point. | yes |
22,889,958 | Is asymmetric dimethylarginine strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis? | {
"contexts": [
"Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase that accumulates in liver disease and may contribute to hepatic encephalopathy (HE). We aimed at evaluating the association of ADMA with cognition and brain MR spectroscopy (MRS) in cirrhosis.",
"Cirrhotic patients wi... | A strong association of ADMA with cognition and prior HE was found independent of the MELD score in cirrhosis. | yes |
22,889,955 | Is raloxifene hydrochloride an adjuvant antiviral treatment of postmenopausal women with chronic hepatitis C : a randomized trial? | {
"contexts": [
"Early menopause in women with chronic hepatitis C virus (HCV) infection is associated with a low likelihood of a sustained virological response (SVR) in conjunction with their antiviral treatment. This is potentially related to their reduced estrogen secretion. The study was done to determine whe... | RLX improved the efficacy of SOC in the treatment of postmenopausal women with chronic hepatitis C. RLX shows promise as an adjuvant to the standard antiviral treatment of such patients. | yes |
22,882,382 | Are increased glutathione and mitogen-activated protein kinase phosphorylation involved in the induction of doxorubicin resistance in hepatocellular carcinoma cells? | {
"contexts": [
" The human hepatocellular carcinoma (HCC) cell line HepG2 can easily acquire resistance to doxorubicin. However, the mechanism of action is unclear.",
" In the present study, we used confocal microscopy, flow cytometry and other methods to reveal the mechanisms by which HepG2 cells acquire ... | These findings reveal that the drug resistance could be acquired through mitogen-activated protein kinase-dependent upregulation of P-gp. This mechanism protects R-HepG2 cells from the anticancer action of doxorubicin. | yes |
22,882,789 | Does low digit ratio predict early age at menarche in Colombian schoolgirls? | {
"contexts": [
"The ratio between the lengths of the second and fourth fingers (digit ratio: 2D : 4D), a purported negative correlate of prenatal androgen exposure, has been inversely related to age at menarche. However, a recent study found high digit ratios in carriers of a single variant in the LIN28B gene, w... | Digit ratio was positively associated with age at menarche in this longitudinal investigation, consistent with results from a recent gene-linkage study. | yes |
22,886,508 | Does angiotensin II type 1 receptor antagonist prevent hepatic carcinoma in rats with nonalcoholic steatohepatitis? | {
"contexts": [
"Angiotensin II type 1 receptor blockers (ARBs) have been reported to attenuate hepatic fibrosis in non-alcoholic steatohepatitis (NASH). However, it is uncertain whether ARBs prevent hepatocarcinogenesis in NASH even after hepatic fibrosis has developed.",
"Male Wistar rats were fed with a ch... | These data indicated that telmisartan may prevent hepatocarcinogenesis through the inhibition of hepatic angiogenesis even after liver cirrhosis has been established. | yes |
22,889,855 | Does bRCA1 R1699Q variant displaying ambiguous functional abrogation confer intermediate breast and ovarian cancer risk? | {
"contexts": [
"Clinical classification of rare sequence changes identified in the breast cancer susceptibility genes BRCA1 and BRCA2 is essential for appropriate genetic counselling of individuals carrying these variants. We previously showed that variant BRCA1 c.5096G>A p.Arg1699Gln in the BRCA1 transcriptiona... | Our results provide substantial evidence that the BRCA1 c.5096G>A p.Arg1699Gln (R1699Q) variant, demonstrating ambiguous functional deficiency across multiple assays, is associated with intermediate risk of breast and ovarian cancer, highlighting challenges for risk modelling and clinical management of patients of this... | yes |
22,906,193 | Does a map of human microRNA variation uncover unexpectedly high levels of variability? | {
"contexts": [
"MicroRNAs (miRNAs) are key components of the gene regulatory network in many species. During the past few years, these regulatory elements have been shown to be involved in an increasing number and range of diseases. Consequently, the compilation of a comprehensive map of natural variability in a... | Despite an expectation that miRNAs would be highly conserved genomic elements, our study reports a level of variability comparable to that observed for coding genes. | yes |
22,880,023 | Is the expression of tubulin cofactor A ( TBCA ) regulated by a noncoding antisense Tbca RNA during testis maturation? | {
"contexts": [
"Recently, long noncoding RNAs have emerged as pivotal molecules for the regulation of coding genes' expression. These molecules might result from antisense transcription of functional genes originating natural antisense transcripts (NATs) or from transcriptional active pseudogenes. TBCA interacts... | Our results demonstrate that Tbca13 mRNA levels are post-transcriptionally regulated by the sense and natural antisense Tbca16 mRNA levels. We propose that this regulatory mechanism operates during spermatogenesis, a process that involves microtubule rearrangements, the assembly of specific microtubule structures and r... | yes |
22,897,936 | Does gLUT4 content decrease along with insulin resistance and high levels of inflammatory markers in rats with metabolic syndrome? | {
"contexts": [
"Metabolic syndrome is characterized by insulin resistance, which is closely related to GLUT4 content in insulin-sensitive tissues. Thus, we evaluated the GLUT4 expression, insulin resistance and inflammation, characteristics of the metabolic syndrome, in an experimental model.",
"Spontaneousl... | MSG-treated SHR presented all metabolic syndrome characteristics, as well as reduced GLUT4 content, which must play a key role in the impaired glycemic homeostasis of the metabolic syndrome. | yes |
22,896,926 | Does gentamicin affect connexin 26 expression in the cochlear lateral wall? | {
"contexts": [
"Aminoglycosides may decrease the expression of some proteins participating in ion-exchange in the cochlear lateral wall. Connexin 26 expression in the lateral wall may play a role in acquired hearing loss by maintaining the endocochlear potential and potassium concentration in the endolymph. We e... | Connexin 26 plays an important role in the acute effects of high-dose gentamicin and is probably involved in the pathogenesis of ototoxic deafness. | yes |
22,894,607 | Does human pancreatic adenocarcinoma contain a side population resistant to gemcitabine? | {
"contexts": [
"Therapy resistance remains one of the major challenges to improve the prognosis of patients with pancreatic cancer. Chemoresistant cells, which potentially also display cancer stem cell (CSC) characteristics, can be isolated using the side population (SP) technique. Our aim was to search for a SP... | We identified a SP in human PDAC and uncovered a chemoresistant and CSC-associated phenotype. This SP may represent a new therapeutic target in pancreatic cancer. | yes |
22,882,730 | Are sex hormone-binding globulin levels causally related to venous thrombosis risk in women not using hormonal contraceptives? | {
"contexts": [
"Oral contraceptive use increases the risk of venous thrombosis as well as sex hormone-binding globulin (SHBG) levels. Furthermore, increased SHBG levels are positively associated with activated protein C (APC) resistance and thrombotic risk in oral contraceptive users.",
"To determine whether... | Increased SHBG levels are not causally related to the risk of venous thrombosis. | no |
22,882,738 | Does evaluation of the osteoconductive potential of bone substitute embedded with schneiderian membrane- or maxillary bone marrow-derived osteoprogenitor cells? | {
"contexts": [
"Sinus augmentation procedures commonly employ osteoconductive scaffolding materials to stimulate and support bone formation. The aim of this study was to develop a simple screening methodology for the evaluation of the osteoconductive potential of various bone graft materials prior to clinical us... | The proposed osteoconductivity testing method proved simple, informative, and reliable for the purpose of screening candidate biomaterials for sinus lifting or sinus augmentation. | yes |
22,897,649 | Do unipolar and bipolar electrogram characteristics predict exit block during pulmonary vein antral isolation? | {
"contexts": [
" The usefulness of unipolar electrograms (EGMs) has been reported in assessing lesion transmurality and conduction block along ablation lines. It is unknown whether unipolar and bipolar EGM characteristics predict exit block during pulmonary vein isolation (PVI) procedures.",
" Twenty patient... | Specific unipolar and bipolar EGM characteristics are associated with left atrium capture after PV antral isolation. These parameters might be useful in predicting the need for further ablation to achieve exit block. | yes |
22,882,249 | Does insulin aspart have a shorter duration of action than human insulin over a wide dose-range? | {
"contexts": [
"Regular human insulin (RHI) at high doses shows prolongation of its duration of action potentially leading to late postprandial hypoglycaemia. This study compared late metabolic activity (4-12 and 6-12 h post-dosing) and duration of action (time to reach late half-maximal activity) over a range o... | IAsp showed a shorter duration of action and, particularly with doses of 12 and 24 (I)U, less late metabolic activity than RHI. These properties might contribute to the lower incidence of hypoglycaemia observed with IAsp versus RHI in clinical trials as lower late metabolic activity should decrease the risk of late pos... | yes |
22,883,388 | Are polymorphisms in the genes coding for iron binding and transporting proteins associated with disability , severity , and early progression in multiple sclerosis? | {
"contexts": [
"Iron involvement/imbalance is strongly suspected in multiple sclerosis (MS) etiopathogenesis, but its role is quite debated. Iron deposits encircle the veins in brain MS lesions, increasing local metal concentrations in brain parenchyma as documented by magnetic resonance imaging and histochemica... | Polymorphisms in the genes coding for iron binding and transporting proteins, in the presence of local iron overload, might be responsible for suboptimal iron handling. This might account for the significant variability peculiar to MS phenotypes, particularly affecting MS risk and progression paving the way for persona... | yes |
22,883,384 | Are monitor units predictive of neutron dose for high-energy IMRT? | {
"contexts": [
"Due to the substantial increase in beam-on time of high energy intensity-modulated radiotherapy (>10 MV) techniques to deliver the same target dose compared to conventional treatment techniques, an increased dose of scatter radiation, including neutrons, is delivered to the patient. As a conseque... | The predicted increase of second cancer induction rates from intensity-modulated treatment techniques can be overestimated when the neutron dose is simply scaled with monitor units. | no |
22,891,197 | Are pre-invasive ovarian mucinous tumors characterized by CDKN2A and RAS pathway aberrations? | {
"contexts": [
"Mucinous tumors are the second most common form of epithelial ovarian tumor, yet the cell of origin for this histologic subtype remains undetermined. Although these tumors are thought to arise through a stepwise progression from benign cystadenoma to borderline tumor to invasive carcinoma, few st... | This study is the largest and highest resolution analysis of mucinous benign and borderline tumors carried out to date and provides strong support for these lesions being precursors of primary ovarian mucinous adenocarcinoma. The high level of uniformity in the molecular events underlying the pathogenesis of mucinous o... | yes |
22,901,973 | Do fat mass and obesity-associated gene polymorphisms affect metabolic response to hormone therapy in healthy postmenopausal women? | {
"contexts": [
"To determine whether fat mass and obesity-associated gene polymorphisms rs9939609 T>A and rs8050136 A>C or their haplotypes influence anthropometric and metabolic variables in recently postmenopausal women receiving hormone therapy.",
"In this randomized crossover study carried out in a unive... | The presence of fat mass and obesity-associated gene risk variants in healthy early postmenopausal women does not adversely affect their response to hormone therapy. | no |
22,892,192 | Is high lactate dehydrogenase levels at admission for painful vaso-occlusive crisis associated with severe outcome in adult SCD patients? | {
"contexts": [
"The aim of this study is to assess biological prognostic factors at the onset of vaso-occlusive crisis (VOC) in adults with sickle cell disease (SCD).",
"A monocentric prospective study including all patients admitted for VOC in a reference center for SCD was utilized. We used multivariate lo... | Further studies should confirm the predictive value of LDH before its widespread use as a prognostic factor. If it is confirmed, the benefit of preemptive transfusion when LDH levels at admission are very high could be investigated. | yes |
22,892,197 | Is the long leg radiograph a reliable method of assessing alignment when compared to computer-assisted navigation and computer tomography? | {
"contexts": [
"The mechanical alignment of the knee is an important factor in planning for, and subsequently assessing the success of a knee replacement. It is most commonly measured using a long-leg anteroposterior radiograph (LLR) encompassing the hip, knee and ankle. Other modalities of measuring alignment i... | Given its availability and reduced radiation dose when compared to CT, LLRs should remain the mainstay of measuring the mechanical alignment of the lower limb, especially post-operatively. | yes |
22,878,968 | Does hip flexion deformity improve without psoas-lengthening after surgical correction of fixed knee flexion deformity in spastic diplegia? | {
"contexts": [
"It is unclear if psoas lengthening surgery is required in the treatment of patients with cerebral palsy (CP) with hip flexion deformity and previous studies show equivocal results with regard to functional outcome.",
"This study retrospectively assessed 12 patients with a diagnosis of spastic... | Our study demonstrates that the hip flexion deformities encountered in these patients will improve spontaneously when the distal fixed knee flexion deformity is surgically corrected. Therefore correction at the knee allows the ground reaction force to assume a more normal position resulting in correction at the hip ove... | yes |
22,878,616 | Is expression of the RET proto-oncogene regulated by TFAP2C in breast cancer independent of the estrogen receptor? | {
"contexts": [
"The RET proto-oncogene is expressed as part of the estrogen receptor (ER) cluster in breast cancer. We sought to determine if TFAP2C regulates Ret expression directly or indirectly through ER.",
"Chromatin immunoprecipitation sequencing (ChIP-Seq) and gel-shift assay were used to identify TFA... | TFAP2C regulates expression of the RET proto-oncogene through five AP-2 regulatory sites in the RET promoter. Regulation of Ret by TFAP2C occurs independently of ER expression in breast carcinoma. | yes |
22,898,989 | Do patients with prostate cancer treated by ADT have significantly higher fibrinogenemia than healthy control? | {
"contexts": [
"Androgen deprivation therapy (ADT) for prostate cancer (PCa) may increase peripheral insulin resistance, induce type 2 diabetes, change body composition, and alter lipoprotein profile. Some studies have reported an association between ADT and increased risk of cardiovascular events. It is known t... | This is the first study that demonstrates the significant increase in FB in PCa patients on ADT, while CRP as inflammatory marker did not increase. Elevation of SF may contribute to increased CVR in PCa patients. Further prospective studies are warranted to confirm this association. | yes |
22,884,115 | Is selective neck dissection effective in N1/N2 nodal stage oral cavity squamous cell carcinoma? | {
"contexts": [
"Although the efficacy of selective neck dissection (SND) in the management of a node-negative neck is established, its utility in the management of node-positive disease remains controversial. The objective of this study was to evaluate the oncologic safety of SND in the management of N1/N2 oral ... | SND may produce a satisfactory ipsilateral regional control rate in patients with early-stage node-positive oral squamous cell carcinoma. A prospective, randomized clinical trial comparing SND with modified radical neck dissection may be required for a categorical conclusion of these findings. | yes |
22,895,070 | Does autophagy limit the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells? | {
"contexts": [
"Mutations that activate the PI3K/AKT/mTOR pathway are relatively common in urothelial (bladder) cancers, but how these pathway mutations affect AKT dependency is not known. We characterized the relationship between AKT pathway mutational status and sensitivity to the effects of the selective AKT ... | The cytostatic effects of AZ7328 correlate with PIK3CA mutations and are greatly enhanced by dual pathway inhibition using an mTOR inhibitor. Furthermore, AZ7328 can interact with autophagy inhibitors to induce apoptosis in some cell lines. Overall, our results support the further evaluation of combinations of PI3K/AKT... | yes |
22,884,796 | Are racial/ethnic disparities in health-related quality of life and health in children largely mediated by family contextual differences? | {
"contexts": [
"To examine (1) racial/ethnic disparities in health-related quality of life (HRQOL), and overall health status among African-American, Hispanic, and white 5th graders in the general population and (2) the extent to which socioeconomic status (SES) and other family contextual variables mediate any ... | Racial/ethnic disparities in children's health status are substantial but may be mediated by corresponding disparities in SES and other family contextual variables. Race/ethnicity and family context are related to one another and should be considered jointly in efforts to reduce health disparities in children. | yes |
22,884,966 | Do risk factors for hypotension in urgently intubated burn patients? | {
"contexts": [
"When urgently intubating patient in the burn intensive care unit (BICU), various induction agents, including propofol, are utilized that may induce hemodynamic instability.",
"A retrospective review was performed of consecutive critically ill burn patients who underwent urgent endotracheal in... | In critically ill burn patients undergoing urgent endotracheal intubation, specific induction agents, including propofol, were not associated with clinically significant hypotension. Presumed sepsis and %TBSA were the most important risk factors. | yes |
22,895,403 | Does magnetoencephalographic imaging of resting-state functional connectivity predict postsurgical neurological outcome in brain gliomas? | {
"contexts": [
"The removal of brain tumors in perieloquent or eloquent cortex risks causing new neurological deficits in patients. The assessment of the functionality of perilesional tissue is essential to avoid postoperative neurological morbidity.",
"To evaluate preoperative magnetoencephalography-based f... | Magnetoencephalography connectivity analysis gives a valuable preoperative evaluation of the functionality of the tissue surrounding tumors in perieloquent and eloquent areas. These data may be used to optimize preoperative patient counseling and surgical strategy. | yes |
22,889,231 | Does carbamazepine directly inhibit adipocyte differentiation through activation of the ERK 1/2 pathway? | {
"contexts": [
"Carbamazepine (CBZ), known for its anti-epileptic, analgesic and mood-stabilizing properties, is also known to induce weight gain but the pathophysiology of this adverse effect is still largely unknown. We tested the hypothesis that CBZ could have a direct effect on adipocyte development and meta... | The effect of CBZ on adipogenesis involves activation of the ERK1/2 pathway. Our results show that CBZ acts directly on pre-adipocytes and adipocytes to alter adipose tissue development and metabolism. | yes |
22,892,126 | Does peroxisome proliferator-activated receptor-δ activation ameliorate albuminuria by preventing nephrin loss and restoring podocyte integrity in type 2 diabetes? | {
"contexts": [
"Peroxisome proliferator-activated receptor (PPAR)-δ is a ligand-activated transcription factor in regulating gene expression and is believed to play an important role in various kidney diseases including diabetic nephropathy. This study investigated the efficacy of GW610742, a highly specific ago... | PPAR-δ activation by GW610742 ameliorates albuminuria by preventing diabetes-induced nephrin loss and restoring podocyte integrity, implying that GW610742 may be a potential therapeutic agent for diabetic nephropathy. | yes |
22,904,014 | Does physician patient communication failure facilitate medication errors in older polymedicated patients with multiple comorbidities? | {
"contexts": [
"To analyse the frequency of mistakes in communication between the physician and the patient and their incidence in errors in self-administered drugs.",
"We undertook a descriptive, cross-sectional study based on interviews with a random sample of patients older than 65 years who were polymedi... | Mistakes by polymedicated patients with multiple comorbidities represent a real risk that should be addressed by the professionals. A review should be made of the routine control questions that the physician asks the patient to identify what other drugs the patient may be taking that have been indicated by another phys... | yes |
22,891,804 | Is atrial fibrillation associated with severe sleep-disordered breathing in patients with ischaemic stroke and transient ischaemic attack? | {
"contexts": [
"Sleep-disordered breathing (SDB) is a risk factor for cerebrovascular disease. We investigated the frequency of SDB in Japanese patients with acute ischaemic stroke and transient ischaemic attack (TIA), as well as factors associated with SDB severity.",
"Between April 2010 and March 2011, we ... | Most Japanese patients with acute ischaemic stroke and TIA had SDB, and AF was associated with SDB. | yes |
22,906,519 | Is altered brain-derived neurotrophic factor expression in the ventral tegmental area , but not in the hippocampus , essential for antidepressant-like effects of electroconvulsive therapy? | {
"contexts": [
"Impaired neuronal plasticity and, specifically, altered expression of brain-derived neurotrophic factor (BDNF) were shown to play a critical role in depressive behavior and the mechanism of various antidepressant treatments including electroconvulsive therapy (ECT). Interestingly, opposing roles ... | While neuroplastic alterations, as expressed by changes in BDNF expression within different brain regions, are induced by ECT, the antidepressant-like effect of ECT in an animal model depends on reduction of VTA BDNF expression but not on the elevation of hippocampal BDNF expression. | yes |
22,906,514 | Does chronic social instability induce anxiety and defective social interactions across generations? | {
"contexts": [
"Chronic social instability during adolescence and early adulthood is known to produce a variety of long-lasting effects that may contribute to future psychiatric disorders. However, its potential to affect future generations has not been tested.",
"Female and male mice were exposed to chronic... | These findings support the idea that individual risk for psychiatric disorders that involve enhanced anxiety and/or social dysfunction may be dependent not only on the specific alleles of genes that are inherited from one's parents and on one's own experiences, but also on the experiences of one's parents when they wer... | yes |
22,906,511 | Does preschoolers ' delay of gratification predict their body mass 30 years later? | {
"contexts": [
"To assess whether preschoolers' performance on a delay of gratification task would predict their body mass index (BMI) 30 years later.",
"In the late 1960s/early 1970s, 4-year-olds from a university-affiliated preschool completed the classic delay of gratification task. As part of a longitudi... | Longer delay of gratification at age 4 years was associated with a lower BMI 3 decades later. Because this study is correlational, it is not possible to make causal inferences regarding the relationship between delay duration and BMI. Identifying children with greater difficulty in delaying gratification could help det... | yes |
22,885,911 | Does gene expression profiling reveal the defining features of monocytes from septic patients with compensatory anti-inflammatory response syndrome? | {
"contexts": [
"To characterize the expression profiles of genes in purified monocytes from septic patients during systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS), and then to investigate the potential mechanism of monocyte deactivation.",
"Lipopolys... | Monocytes from CARS patients exhibited significant changes in mRNA expression of genes associated with phagocytosis, antigen presentation, inflammatory response, cell migration, and apoptosis, which might cause deactivation of monocytes during CARS. | yes |
22,877,648 | Is the high glucose-induced stimulation of B1R and B2R expression via CB ( 1 ) R activation involved in rat podocyte apoptosis? | {
"contexts": [
"We examined renal kallikrein-kinin system (KKS) apoptosis and its related signaling pathway in rat podocytes. In addition, we studied the relationship of cannabinoid receptor 1 (CB(1)R) with high glucose and BK receptors.",
"Cell viability was determined by an MTT assay and apoptosis by DNA f... | Our study suggests that hyperglycemia induces apoptosis via the stimulation of B1R and B2R expression through CB(1)R activation in rat podocytes in vitro, which is associated with the development of diabetic nephropathy. | yes |
22,892,745 | Is microbial biofilm proliferation within sealer-root dentin interfaces affected by sealer type and aging period? | {
"contexts": [
"Root canal fillings are intended to prevent microbial proliferation over time in the canal after treatment. The objective of this study was to assess biofilm proliferation within the sealer-dentin interfaces of 2 methacrylate resin-based systems, self-etch (SE) and total-etch (TE), and an epoxy r... | Within the test model used, the SE and EP sealers were more susceptible to interfacial biofilm proliferation than the TE restorative material. This susceptibility diminished after aging the materials' interfaces for 6 months. | yes |
22,885,643 | Do the correlation between human papillomavirus positivity and abnormal cervical cytology result differs by age among perimenopausal women? | {
"contexts": [
"We explored the age-stratified correlates and correlations between high-risk human papillomavirus (HR-HPV) infection and cervical abnormalities in perimenopausal women.",
"Human papillomavirus testing and Pap smear screening were performed at baseline on 841 routinely screened women age 35 to... | Although the relative proportion of low-grade and high-grade abnormalities did not change with age, we saw a loss of concordance between HR-HPV detection and cytological abnormalities with increasing age. Current guidelines for cervical cancer screening group together all women age 30 years and older. Our data raise im... | yes |
22,878,918 | Does probucol ameliorate the development of nonalcoholic steatohepatitis in rats fed high-fat diets? | {
"contexts": [
"We sought to evaluate the effects of probucol on steatohepatitis and associated molecular mechanisms in a rat model of nonalcoholic steatohepatitis (NASH) induced by high-fat diet (HFD).",
"Forty male rats weighing 100-120 g were randomly assigned to the following treatments (n = 10 for each ... | Probucol shows beneficial effects on HFD-induced steatohepatitis by improving insulin resistance and attenuating oxidative stress and systemic inflammation. | yes |
22,878,917 | Do not all side population cells contain cancer stem-like cells in human gastric cancer cell lines? | {
"contexts": [
"Side population (SP) cells may play a crucial role in tumorigenesis and the recurrence of cancer. Many kinds of cell lines and tissue have demonstrated presence of SP cells including different gastric cancer cell lines. However, is that true all SP cells contain cancer stem-like cells in gastric ... | SP cells from MKN-45 possess cancer stem cell properties and proved that they were gastric cancer stem-like cells. SP cells from BGC-823 didn't possess cancer stem cell properties and proved that not all SP cells contain cancer stem-like cells in gastric cancer cell lines. | yes |
22,901,381 | Does three-dimensional invasion of human glioblastoma cells remain unchanged by X-ray and carbon ion irradiation in vitro? | {
"contexts": [
"Cell invasion represents one of the major determinants that treatment has failed for patients suffering from glioblastoma. Contrary findings have been reported for cell migration upon exposure to ionizing radiation. Here, the migration and invasion capability of glioblastoma cells on and in colla... | These findings indicate that X-rays and carbon ion irradiation effectively reduce proliferation and clonogenic survival without modifying the migration and invasion ability of glioblastoma cells in a collagen type I environment. Addition of targeted agents against members of the MAPK and PI3K signaling axis to conventi... | yes |
22,907,476 | Do motion and pain relief remain 23 years after manipulation under anesthesia for frozen shoulder? | {
"contexts": [
"Manipulation under anesthesia (MUA) as treatment for idiopathic frozen shoulder increases motion, provides pain relief, and restores function, but it is unclear whether the improvements persist long term.",
"We therefore investigated whether (1) ROM was restored, (2) pain was relieved, and (3... | In this group of patients treatment of idiopathic frozen shoulder by MUA led to improvement in shoulder motion and function at a mean 23 years after the procedure. | yes |
22,902,791 | Is donor clara cell secretory protein polymorphism a risk factor for bronchiolitis obliterans syndrome after lung transplantation? | {
"contexts": [
"We hypothesized that a reduced potential for bronchiolar stem-cell (Clara cell)-related repair in the setting of an ever-present risk of small airway injury would increase the risk of bronchiolitis obliterans syndrome (BOS).",
"CCSP A38G gene polymorphism was assessed in both lung donors and ... | Donor CCSP A38G polymorphism is associated with decreased CCSP levels early after lung transplantation and poor long-term outcomes. | yes |
22,902,792 | Do tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival? | {
"contexts": [
"Thymic-derived Foxp3(+)CD4(+) regulatory T cells (Tregs)-also called natural Tregs-are critical for the induction and maintenance of transplantation tolerance. Using an agonistic tumor necrosis factor-receptor super family (TNFRSF) 25 antibody, clone 4C12, we showed that TNFRSF25 is a powerful re... | TNFRSF25 agonists expand Tregs in vivo and delay allograft rejection. | yes |
22,902,807 | Is disialo-trisialo bridging of transferrin due to increased branching and fucosylation of the carbohydrate moiety? | {
"contexts": [
"Carbohydrate deficient transferrin (CDT) is used for detection of alcohol abuse and follow-up. High performance liquid chromatography (HPLC) of transferrin glycoforms is highly specific for identification of alcohol abuse, but unresolved disialo- and trisialotransferrin glycoforms sometimes makes... | The di-tri bridging phenomenon was associated with alterations in transferrin glycosylation in the majority of cases. Transferrin contained a higher extent of triantennary and often fucosylated N-linked oligosaccharides. These results may be important in future diagnostic approaches to liver diseases. | yes |
22,892,990 | Does the functional polymorphism Ala258Ser in the innate receptor gene ficolin-2 in the donor predict improved renal transplant outcome? | {
"contexts": [
"Innate immunity plays a role in controlling adaptive immune responses.",
"We investigated the clinical relevance of single nucleotide polymorphisms in 22 genes encoding innate, secreted, and signaling pattern recognition receptors in a total of 520 donor-recipient pairs of postmortem, human l... | Presence of the ficolin-2 Ala258Ser polymorphism in the donor independently predicts improved graft outcome. Based on mechanistic data, we propose that this functional polymorphism leads to more efficient handling of injured cells by phagocytozing cells, resulting in decreased intragraft exposure to danger signals and ... | yes |
22,892,992 | Do kidneys from older living donors provide excellent intermediate-term outcomes after transplantation? | {
"contexts": [
"Despite the increasing use of older living donors in kidney transplantation, intermediate-term donor and recipient outcomes are poorly characterized.",
"We retrospectively compared 143 recipients from donors older than 50 years (older) to 319 recipients from donors 50 years or younger (younge... | Older living donor kidneys can be transplanted with low perioperative risk without compromising recipient 5-year patient or graft survival or donor renal function. Younger donor kidneys have superior graft function 5 years after transplantation, highlighting the need for appropriate donor/recipient matching. | yes |
22,878,403 | Does combination evaluation of preoperative risk indices predict requirement of biventricular assist device? | {
"contexts": [
"Patients with biventricular assist device (BiVAD) placement have a poor prognosis, but preoperative risk factors for the necessity of BiVAD have not been fully elucidated.",
"Data from 79 patients who received left ventricular assist device (LVAD) between November 2002 and December 2011 were ... | The new scoring method, which includes CVP/PCWP ratio, is a novel risk stratification tool for BiVAD therapy. | yes |
22,902,522 | Does fish oil supplementation augment post-exercise immune function in young males? | {
"contexts": [
"Fish oils and related fatty acid components have anti-inflammatory properties, with beneficial effects against various disorders such as cardiovascular disease. A single bout of exercise can alter immune function. However, the effects of fish oil on immune function after a single bout of exercise... | The current study demonstrates that fish oil supplementation reduces increases PBMC IL-2 production and NK cell cytotoxic activity in the recovery period after exercise. | yes |
22,902,873 | Does submaximal suppression of parathyroid hormone ameliorate calcitriol-induced aortic calcification and remodeling and myocardial fibrosis in uremic rats? | {
"contexts": [
"In subtotally nephrectomized rats, we studied to what extent high-dose calcitriol-induced cardiovascular disease can be modulated by almost complete suppression of parathyroid hormone (PTH), mediated by either cinacalcet (CINA) or parathyroidectomy (PTX).",
"Five groups were studied: sham-ope... | Submaximal suppression of PTH by either CINA or PTX reduced vascular calcifications, arterial remodeling and myocardial fibrosis to a similar degree and independent of the serum calcium and phosphorus levels. These data do not indicate vasculotropic effects of calcimimetics independent of PTH suppression. | yes |
22,905,292 | Does lipopolysaccharide trigger nuclear import of Lpcat1 to regulate inducible gene expression in lung epithelia? | {
"contexts": [
"To report that Lpcat1 plays an important role in regulating lipopolysaccharide (LPS) inducible gene transcription.",
"Gene expression in Murine Lung Epithelial MLE-12 cells with LPS treatment or Haemophilus influenza and Escherichia coli infection was analyzed by employing quantitative Revers... | These observations suggest that Lpcat1 relocates into the nucleus in response to bacterial infection to differentially regulate gene transcriptional repression. | yes |
22,909,383 | Does characterization of bovine FUT7 further understanding of FUT7 evolution in mammals? | {
"contexts": [
"The Sialyl-Lewis X (Slex) is a well-known glycan structure involved in leukocyte homing and recruitment to inflammatory sites. SLex is well conserved among species and is mainly synthesized by FucT-VII in vertebrates. The enzyme responsible for its biosynthesis in cattle was not known.",
"We ... | The FUT7 sequence was highly conserved as well as the specific activity of the encoded protein FucT-VII. In addition, our in silico promoter analysis and the high rate of polymorphism suggested that its function is evolving toward a complex system related to the immune system. Furthermore, comparing bovine to human and... | yes |
22,882,749 | Is gNB3 C825T polymorphism associated with postural tachycardia syndrome in children? | {
"contexts": [
"Postural tachycardia syndrome (POTS) is one of the most frequent forms of chronic orthostatic intolerance in children and adolescents. The aim of the present study was to examine the influence of a genetic background on POTS.",
"A total of 96 children and adolescents with orthostatic dysregul... | The gene polymorphisms GNB3 C825T might be a risk factor for POTS through the enhanced vagal withdrawal of the heart in children and adolescents. | yes |
22,878,786 | Does tumor infiltration in the medial resection margin predict survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma? | {
"contexts": [
"Microscopic tumor involvement (R1) in different surgical resection margins after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC) has been debated.",
"Clinico-pathological data for 258 patients who underwent PD between 2001 and 2010 were retrieved from a prospective da... | The medial surgical resection margin is the most important after PD for PDAC, and an R1 resection here predicts poor survival. | yes |
22,890,118 | Do alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice? | {
"contexts": [
"Ischemia-reperfusion (I-R) injury is a sterile inflammatory process that is commonly associated with diverse clinical situations such as hemorrhage followed by resuscitation, transient embolic events, and organ transplantation. I-R injury can induce lung dysfunction whether the I-R occurs in the ... | The data reveal that alveolar macrophages and the pattern recognition receptor toll-like receptor-4 are involved in the generation of the early inflammatory response to lung I-R injury. | yes |
22,890,165 | Does bufalin induce the apoptosis of acute promyelocytic leukemia cells via the downregulation of survivin expression? | {
"contexts": [
"Bufalin is a cardiotonic steroid isolated from the Chinese toad venom preparation Chan'su and has been shown to induce leukemia cell differentiation and apoptosis under certain experimental conditions. However, the detailed mechanism by which bufalin induces the apoptosis of acute promyelocytic l... | Bufalin is a potential regimen to be used in combination with conventional chemotherapeutic drugs to improve acute promyelocytic leukemia therapy. | yes |
22,884,669 | Are elevated serum levels of high mobility group box 1 ( HMGB1 ) protein in dengue-infected patients associated with disease symptoms and secondary infection? | {
"contexts": [
"Dengue virus (DENV) is described as the most prevalent arbovirus, infecting at least 50 million people worldwide. During infection, an intricate network of cytokines, a group of substances closely related to disease severity, is released. Recently, it was observed that both DENV-infected epitheli... | We hypothesize that HMGB1 levels correlate with disease pathogenesis, specifically with the clinical symptoms and secondary infection, implicating a pro-inflammatory cytokine role for HMGB1 in DENV infection. This is the first report assessing the circulating levels of HMGB1 during DENV infection. | yes |
22,892,062 | Is basal Ki67 expression measured by digital image analysis optimal for prognostication in oral squamous cell carcinoma? | {
"contexts": [
"The prognostic significance of Ki67 expression in cancers, including oral squamous cell carcinoma (OSCC), is unclear. This may be partly attributed to the lack of consensus surrounding the optimal approach for measuring tumour Ki67 expression. The aim of this study was to evaluate the association... | Our study provides a framework for reaching a consensus on the optimal approach for measuring Ki67 expression in cancers. Our results suggest that rigorous comparisons of measurement approaches should be applied in a tumour-type and treatment-specific manner to enhance the clinical application of Ki67 assessment. | yes |
22,880,267 | Is [ Quality of life an important factor in the indication in patients with advanced pancreatic carcinoma -- a prospective multicentric study ]? | {
"contexts": [
"The aim of this report is to present results of prospective multicentric study on quality of life (QoL) in advanced ductal pancreatic adenocarcinoma patients.",
"In 426 patients with advanced ductal pancreatic adenocarcinoma, the following parameters were studied: type of treatment, complicat... | Based on the results of the multicentric prospective study in patients with locally advanced stage III and IV ductal pancreatic adenocarcinoma, the following conclusions can be presented: (1) median and 1, 2 and 3-year survival rates in stage III patients were significantly higher in the RR group compared to the paliat... | yes |
22,883,108 | Is ghWRKY15 , a member of the WRKY transcription factor family identified from cotton ( Gossypium hirsutum L. ) , involved in disease resistance and plant development? | {
"contexts": [
"As a large family of regulatory proteins, WRKY transcription factors play essential roles in the processes of adaptation to diverse environmental stresses and plant growth and development. Although several studies have investigated the role of WRKY transcription factors during these processes, th... | Overall, our data suggest that overexpression of GhWRKY15 may contribute to the alteration of defence resistance to both viral and fungal infections, probably through regulating the ROS system via multiple signalling pathways in tobacco. It is intriguing that GhWRKY15 overexpression in tobacco affects plant growth and ... | yes |
22,906,847 | Does olmesartan improve coronary flow reserve of hypertensive patients using coronary magnetic resonance imaging compared with amlodipine? | {
"contexts": [
"Hypertension impairs coronary endothelial cell function, coronary microvascular function and the coronary flow (CF) reserve (CFR). Angiotensin II receptor blockers (ARBs) have been reported to possibly improve coronary endothelial function and coronary microvascular function. The purpose of this ... | Olmesartan, but not amlodipine, improves CFR in hypertensive patients. | yes |
22,887,048 | Is end tidal carbon dioxide as reliable as transcutaneous monitoring in ventilated postsurgical neonates? | {
"contexts": [
"To compare the agreement, precision and repeatability of end tidal carbon dioxide (EtCO2 ) and transcutaneous carbon dioxide (TcCO2 ) with partial pressure of arterial CO(2) ( PaCO2) in postoperative neonates.",
"Fifty mechanically ventilated neonates without lung disease, and with no contrai... | In postoperative neonates, EtCO2 and TcCO2 demonstrated a clinically acceptable agreement with PaCO2. | yes |
22,907,617 | Does appropriate antibiotic therapy improve Ureaplasma sepsis outcome in the neonatal mouse? | {
"contexts": [
"Ureaplasma causes sepsis in human neonates. Although erythromycin has been the standard treatment, it is not always effective. No published reports have evaluated Ureaplasma sepsis in a neonatal model. We hypothesized that appropriate antibiotic treatment improves Ureaplasma sepsis in a neonatal ... | We have established a neonatal model of Ureaplasma sepsis and observed that treatment outcome is related to infecting strain and antibiotic treatment. We speculate that appropriate antibiotic selection and dosing are required for effective treatment of Ureaplasma sepsis in neonates, and this model could be used to furt... | yes |
22,878,099 | Does high expression of ADAM8 correlate with poor prognosis in hepatocellular carcinoma? | {
"contexts": [
"To evaluate the association between ADAM8 tissue expression and patient prognosis in hepatocellular carcinoma (HCC).",
"ADAM8 expression was analyzed using immunohistochemical staining methods on tissue samples from a consecutive series of 105 HCC patients who underwent resections between 200... | These findings provide evidence that a high expression level of ADAM8 serves as a biomarker for poor prognosis for HCC. Thus, we speculate that ADAM8 may be a potential target of antiangiogenic therapy for HCC. | yes |
22,882,281 | Does exenatide at therapeutic and supratherapeutic concentrations prolong the QTc interval in healthy subjects? | {
"contexts": [
"Exenatide has been demonstrated to improve glycaemic control in patients with type 2 diabetes, with no effect on heart rate corrected QT (QTc ) at therapeutic concentrations. This randomized, placebo- and positive-controlled, crossover, thorough QT study evaluated the effects of therapeutic and s... | These results demonstrated that exenatide, at supratherapeutic concentrations, does not prolong QTc and provide an example of methodology for QT assessment of drugs with an inherent heart rate effect. | no |
22,897,969 | Does sigE facilitate the adaptation of Bordetella bronchiseptica to stress conditions and lethal infection in immunocompromised mice? | {
"contexts": [
"The cell envelope of a bacterial pathogen can be damaged by harsh conditions in the environment outside a host and by immune factors during infection. Cell envelope stress responses preserve the integrity of this essential compartment and are often required for virulence. Bordetella species are i... | Much of the work on transcriptional regulation during infection in B. bronchiseptica has focused on the BvgAS two-component system. This study reveals that the SigE regulon also mediates a discrete subset of functions associated with virulence. SigE is the first cell envelope stress-sensing system to be described in th... | yes |
22,907,795 | Is comorbidities remission after Roux-en-Y Gastric Bypass for morbid obesity sustained in a long-term follow-up and correlates with weight regain? | {
"contexts": [
"Obesity-related comorbidities are treated by Roux-en-Y gastric bypass (RYGB) due to weight loss and intestinal hormone changes. Few studies report the evolution of these comorbidities in a long-term follow-up, especially if weight regain is present. This study aims to analyze: (1) the resolution ... | Our results show that comorbidities remission after RYGB is sustained in a long-term follow-up. Weight regain is linked to worse results for all comorbidities except infertility. | yes |
22,878,758 | Is early oral feeding following intestinal anastomoses in children safe? | {
"contexts": [
"Oral feeding following intestinal anastomoses is frequently delayed. In settings with limited utilisation of parenteral nutrition, this policy is problematic. This report evaluates the safety of early oral feeding following intestinal anastomoses in children.",
"A prospective study including ... | Early oral feeding following intestinal anastomoses in children is safe, particularly in the setting of limited availability of parenteral nutrition. | yes |
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