pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
22,884,017 | Are tumor necrosis factor-alpha promoter polymorphisms associated with idiopathic primary ovarian insufficiency in Korean women? | {
"contexts": [
"To investigate the possible association between primary ovarian insufficiency (POI) and TNF-α gene polymorphisms in Korean women.",
"Case-control study.",
"An urban university-based hospital in South Korea.",
"A cohort of 135 Korean POI patients and 236 controls.",
"None.",
"W... | The TNF-α -1031C and -238A alleles had strong association with POI. The TNF-α -308A allele showed limited significance for POI risk with the presence of the -1031T allele. Our data suggest that the minor alleles of TNF-α promoter polymorphisms may increase POI risk in Korean women. | yes |
22,884,190 | Is abdominal muscle feedforward activation in patients with chronic low back pain largely unaffected by 8 weeks of core stability training? | {
"contexts": [
"Does timing of abdominal muscle activation in response to rapid shoulder flexion change after 8 weeks with low-load core stability exercises (CSE), high-load sling exercises (SE), or general exercises (GE) in chronic nonspecific low back pain (LBP) patients?",
"A randomised, controlled trial ... | Abdominal muscle onset was largely unaffected by 8 weeks of exercises in chronic LBP patients with changes in onset of less than 20 milliseconds between groups. | yes |
22,898,763 | Is the ratio of visceral to subcutaneous fat , a metric of body fat distribution , a unique correlate of cardiometabolic risk? | {
"contexts": [
"The anatomic location of excess body fat has an impact on associated cardiometabolic morbidity, and visceral adipose tissue (VAT) is more pathogenic than subcutaneous adipose tissue (SAT). However, VAT or SAT alone provides little information regarding the relative distribution of body fat. We hy... | VAT/SAT ratio is a correlate of cardiometabolic risk, above and beyond BMI and VAT. The propensity to store fat viscerally versus subcutaneously may be a unique risk factor independent of absolute fat volumes. | yes |
22,906,259 | Does wortmannin reduce metastasis and angiogenesis of human breast cancer cells via nuclear factor-κB-dependent matrix metalloproteinase-9 and interleukin-8 pathways? | {
"contexts": [
"To investigate whether inhibition of Akt phosphorylation by the phosphatidylinositol 3-kinase (PI3K) inhibitor, wortmannin, reduces metastasis and angiogenesis in a human breast cancer cell line via nuclear factor (NF)-κB-dependent matrix metalloproteinase (MMP)-9 and interleukin (IL)-8 pathways.... | The findings of the present study suggest that wortmannin inhibits metastasis and angiogenesis in breast cancer cells via PI3K/Akt/NF-κB-mediated MMP-9 and IL-8 signalling pathways. | yes |
22,906,251 | Do epidural analgesia and laparoscopic technique reduce incidence of prolonged ileus in elective colon resections? | {
"contexts": [
"This study evaluated the incidence and risk factors for prolonged ileus in patients undergoing elective colon resection.",
"Retrospective data were obtained in patients undergoing open colectomy with or without epidural analgesia and laparoscopic colectomy at a university-affiliated Veterans ... | The incidence of prolonged ileus was similar in the 3 groups studied. However, the epidural and laparoscopic groups experienced earlier return of bowel function and toleration of diet than the nonepidural group. | no |
22,898,243 | Do left cardiac chambers reverse remodeling after percutaneous mitral valve repair with the MitraClip system? | {
"contexts": [
"Successful mitral valve surgical repair, decreasing volume overload, has been shown to provide reverse left ventricular (LV) and/or left atrial remodeling in most patients. Percutaneous mitral valve repair with the MitraClip system (Abbott, Abbott Park, IL) has been associated with favorable clin... | The present study reports positive LV reshape effects after mitral valve repair with the MitraClip system, showing significant improvements in LV size and function. | yes |
22,887,850 | Do changes in estimated right ventricular systolic pressure predict mortality and pulmonary hypertension in a cohort of scleroderma patients? | {
"contexts": [
"Annual echocardiography screening is widely used in scleroderma, but the utility of longitudinal assessment is unknown. We evaluated whether change in right ventricular systolic pressure (RVSP) was a risk factor for mortality and development of pulmonary arterial hypertension (PAH) in a cohort of... | In a population of scleroderma patients, the rate of increase in RVSP is a risk factor for mortality and PAH even after adjustment for clinical characteristics and longitudinal PFT data. | yes |
22,889,324 | Does sHP-2 phosphatase promote cervical cancer cell proliferation through inhibiting interferon-β production? | {
"contexts": [
"The aim of this study was to explore the effect of Src-homology-2-domain-containing protein, tyrosine phosphatase 2 (SHP-2) on the proliferation of cervical cancer cells.",
"A total of 45 patients with cervical cancer (stage I-III), 32 with cervical intraepithelial neoplasia and 20 healthy su... | SHP-2 phosphatase promotes cervical cancer cell proliferation through inhibiting IFN-β production. | yes |
22,886,376 | Is periventricular nodular heterotopia related to severity of the hindbrain deformity in Chiari II malformation? | {
"contexts": [
"Knowledge of the occurrence of malformations of cortical development (MCDs) and its relationship to hindbrain deformity in Chiari II malformation (CIIM) is limited.",
"To assess malformations of cortical development and its relationship to hindbrain deformity regarding Chiari II malformation.... | Periventricular nodular heterotopia was seen in a relatively high proportion of children with Chiari II malformation, suggesting that it may be associated with severe hindbrain deformity. | yes |
22,906,651 | Is prostatic fibrosis associated with lower urinary tract symptoms? | {
"contexts": [
"Current therapies for male lower urinary tract symptoms secondary to prostate enlargement prevent hormonal effects on prostate growth and inhibit smooth muscle contraction to ease bladder neck and urethral pressure. However, lower urinary tract symptoms can be refractory to these therapies, sugge... | Findings show that extracellular matrix deposition and fibrosis characterize the periurethral prostate tissue of some men with lower urinary tract symptoms. They point to fibrosis as a factor contributing to lower urinary tract symptom etiology. | yes |
22,880,182 | Is routine barium enema prior to closure of defunctioning ileostomy necessary? | {
"contexts": [
"The use of barium enemas to confirm the anastomotic integrity prior to ileostomy closure is still controversial. The purpose of the study was to determine the utility of routine contrast enema prior to ileostomy closure and its impact on patient management in patients with a low pelvic anastomosi... | Routine barium enema evaluation of low pelvic anastomoses before loop ileostomy closure did not provide any additional information for postoperative colorectal anastomotic complication. | no |
22,898,137 | Is overexpression of BMI-1 associated with poor prognosis in cervical cancer? | {
"contexts": [
"It has been reported that BMI-1, a gene transcription promoter overexpressed in various human cancers, is associated with poor survival. We investigated whether BMI-1 is a marker for cervical cancer by detecting the expression of BMI-1 in cervical cancer.",
"An immunohistochemistry (IHC) stre... | The high expression of BMI-1 in cervical cancer is related to tumor progression, lymph node metastasis and HPV infection, suggesting that cervical cancer with excessive BMI-1 expression possesses high metastases potential and that BMI-1 may be a promising biomarker for predicting metastasis in cervical cancer. | yes |
22,903,204 | Is overexpression of metadherin/MTDH associated with an aggressive phenotype and a poor prognosis in invasive breast cancer? | {
"contexts": [
"Metadherin (MTDH) plays functional roles in the tumorigenesis and tumor progression of various cancers. This study investigated the associations between MTDH and the clinicopathological features in primary breast carcinomas to clarify the role of MTDH in the phenotypes and prognosis of breast can... | MTDH overexpression contributes to an aggressive phenotype, thus leading to a poor prognosis for primary invasive breast cancer. | yes |
22,906,283 | Does addition of adrenaline to chloroprocaine provide a moderate duration time for epidural anaesthesia in elective caesarean section? | {
"contexts": [
"Epidural anaesthesia using chloroprocaine with or without adrenaline and lidocaine with adrenaline were compared.",
"Sixty parturients undergoing elective caesarean section under epidural anaesthesia were randomized to receive 3% chloroprocaine (group C), 3% chloroprocaine with adrenaline (g... | Epidural anaesthesia using chloroprocaine with adrenaline has a quick onset and moderate duration and is an attractive alternative to lidocaine and adrenaline or chloroprocaine alone for caesarean section. | yes |
22,906,282 | Is extracellular matrix metalloproteinase inducer associated with severity of brain oedema following experimental subarachnoid haemorrhage in rats? | {
"contexts": [
"Brain oedema is a major cause of clinical deterioration and death following brain trauma; cellular mechanisms involved in its development remain elusive. This study investigated the role of extracellular matrix metalloproteinase inducer (EMMPRIN) in brain oedema.",
"The monofilament puncture ... | EMMPRIN upregulation may be important in the formation of brain oedema; inhibition of EMMPRIN activity may provide a potential approach to reduce oedema after subarachnoid haemorrhage. | yes |
22,905,635 | Is fruit drink consumption associated with overweight and obesity in Canadian women? | {
"contexts": [
"Overweight and obesity in Canada have significantly increased during the last three decades, paralleled by increased intake of fat and sugar, particularly sugary beverages. The Canadian Community Health Survey, Cycle 2.2, conducted in 2004 (CCHS 2.2), provides the opportunity to evaluate beverage... | Using a nationally representative dataset, there was an association between sugar-sweetened beverages and overweight and obesity in Canadian women. | yes |
22,882,409 | Do mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic rhinitis? | {
"contexts": [
"Human induced pluripotent stem cells (iPSCs) possess remarkable self-renewal capacity and the potential to differentiate into novel cell types, such as mesenchymal stem cells (MSCs). iPSC-MSCs have been shown to enhance tissue regeneration and attenuate tissue ischaemia; however, their contributi... | These data demonstrate that iPSC-MSCs are capable of modulating T-cell phenotypes towards Th2 suppression through inducing Treg expansion, suggesting that iPSC-MSCs can be used as an alternative candidate to adult MSCs to treat allergic airway diseases. | yes |
22,900,910 | Does use of porous trabecular metal augment with impaction bone grafting in management of acetabular bone loss? | {
"contexts": [
"The use of impaction grafting in revisions with larger acetabular bone defects has mixed outcomes and sometimes high failures rates.",
"This prospective, single-center study involved a consecutive series of 24 patients who underwent complex reconstruction of the acetabulum using a trabecular ... | This study shows that trabecular metal augments are effective in filling the bone defect and provide a stable foundation for impaction bone grafting. We found satisfactory clinical and radiographic results using this technique, with low failure rate at a median follow-up time of 5 years. | yes |
22,905,245 | Is obesity underestimated using body mass index and waist-hip ratio in long-term adult survivors of childhood cancer? | {
"contexts": [
"Obesity, represented by high body mass index (BMI), is a major complication after treatment for childhood cancer. However, it has been shown that high total fat percentage and low lean body mass are more reliable predictors of cardiovascular morbidity. In this study longitudinal changes of BMI an... | Sixteen years after treatment for childhood cancer, the increase in BMI and total fat percentage was significantly greater than expected, especially after CRT. This is important as we could show that obesity was grossly underestimated using BMI and waist-hip ratio. | yes |
22,898,620 | Does sulforaphane inhibit restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells? | {
"contexts": [
"Sulforaphane, a naturally occurring organosulfur compound in broccoli, has chemopreventive properties in cancer. However, the effects of sulforaphane in vascular diseases have not been examined. We therefore aimed to investigate the effects of sulforaphane on vascular smooth muscle cell (VSMC) pr... | Our results indicate that sulforaphane inhibits neointima formation via targeting of adhesion molecules through the suppression of NF-κB/GATA6. Furthermore, sulforaphane regulates migration and proliferation in VSMCs. Sulforaphane may be a potential therapeutic agent for preventing restenosis after vascular injury. | yes |
22,903,704 | Does receptor for activated C kinase 1 promote hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity? | {
"contexts": [
"c-Jun N-terminal protein kinase (JNK) is a member of the mitogen-activated protein kinase (MAPK) superfamily. The activation of JNK is mediated by sequential protein phosphorylation through a MAPK module, namely, MAPK kinase kinase (MAP3K or MEKK) → MAPK kinase (MAP2K or MKK) → MAPK. Elevated lev... | Overexpressed RACK1 augments JNK activity and thereby promotes HCC growth through directly binding to MKK7 and enhancing MKK7 activity. | yes |
22,900,495 | Is interstitial magnetic resonance lymphography an effective diagnostic tool for the detection of lymph node metastases in patients with cervical cancer? | {
"contexts": [
"The aim of the present study was to determine the feasibility of detecting sentinel lymph node (SLN) metastases using interstitial magnetic resonance (MR) lymphography in patients with cervical cancer. MR data were compared to pathological results from the lymph nodes excised during surgery.",
... | Interstitial MR lymphography can be used to determine the extent and shape of pelvic lymphatic vessel drainage and lymph node metastases in patients with cervical cancer. | yes |
22,889,197 | Is interleukin-6 the strongest predictor of 30-day mortality in patients with cardiogenic shock due to myocardial infarction? | {
"contexts": [
"Cardiogenic shock (CS) remains the leading cause of death in patients hospitalized for myocardial infarction (MI). Systemic inflammation with inappropriate vasodilatation is observed in many patients with CS and may contribute to an excess mortality rate. The purpose of this study was to determin... | In patients with MI complicated by CS, IL-6 represented a reliable independent early prognostic marker of 30-day mortality. PCT revealed a significant value at later points in time, whereas Nt-proBNP seemed to be of lower relevance. | yes |
22,882,719 | Do microstructural abnormalities of white matter differentiate pediatric and adult-onset bipolar disorder? | {
"contexts": [
"White-matter microstructure, known to undergo significant developmental transformation, is abnormal in bipolar disorder (BD). Available evidence suggests that white-matter deviation may be more pronounced in pediatric than adult-onset BD. The present study aimed to examine how white-matter micros... | The ALIC connects the frontal lobes with archistriatum, thalamus, and medial temporal regions, and alteration in these pathways may contribute to mood dysregulation in BD. Abnormalities in this pathway appear to be associated with an earlier onset of illness and thus may reflect a greater susceptibility to illness. | yes |
22,877,792 | Do haplotypes of susceptibility to chronic periodontitis in the Interleukin 8 gene influence protein level in the gingival crevicular fluid? | {
"contexts": [
"Previously, we identified that the ATC/TTC haplotype formed by polymorphisms in the Interleukin-(IL)8 gene conferred susceptibility to chronic periodontitis (CP). The aim of the study was to investigate whether the IL8 haplotype ATC/TTC was associated with the volume of gingival crevicular fluid ... | The IL8 haplotype of susceptibility to CP was neither associated with IL-8 cytokine levels nor with clinical periodontal parameters. Also, CP, IL8 haplotype and IL-8 concentration showed a positive association with the GCF volume levels in the studied patients. | no |
22,877,795 | Is cruciferous vegetables intake inversely associated with risk of breast cancer : a meta-analysis? | {
"contexts": [
"The objective of the study was to examine the associations of cruciferous vegetables intake with risk of breast cancer.",
"Studies were identified by searching PubMed databases and screening the references of retrieved articles and reviews. Summary odds ratios (ORs) for the highest versus low... | Findings from this meta-analysis suggest that cruciferous vegetables consumption may reduce the risk of breast cancer. Because of the limited number of studies, further prospective studies are needed to explore the protective effect of cruciferous vegetables on breast cancer. | yes |
22,905,058 | Does subclinical haemorrhagic tendency exist in patients with β-thalassaemia major in early childhood? | {
"contexts": [
"Alterations of coagulation profile have been reported in patients with β-thalassaemia major (β-TM).",
"To investigate this in the paediatric population, we studied haemostatic parameters in pre-transfusion blood samples from 50 non-splenectomised transfusion-dependent children with β-TM (mean... | The findings from this study suggest that a subclinical haemorrhagic tendency exists in patients with β-TM at a very early age. The intrinsic pathway appears to be more affected than the extrinsic pathway. | yes |
22,890,813 | Does aVE3085 protect coronary endothelium from the impairment of asymmetric dimethylarginine by activation and recoupling of eNOS? | {
"contexts": [
"Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of eNOS and it is recognized as a risk factor for endothelial dysfunction in cardiovascular diseases. We investigated the effect of AVE3085, a newly developed transcription enhancer of eNOS, on ADMA-induced endothelial dysfunction in c... | AVE3085 prevents ADMA-induced endothelial dysfunction in coronary arteries. The protective effect of AVE3085 may be attributed to increased NO production resulting from enhanced eNOS activation, and decreased oxidative stress that involves inhibition of O (2) (.-) generation by eNOS recoupling. The present study sugges... | yes |
22,881,838 | Does the novel NOX inhibitor 2-acetylphenothiazine impair collagen-dependent thrombus formation in a GPVI-dependent manner? | {
"contexts": [
"NADPH oxidases (NOXs) contribute to platelet activation by a largely unknown mechanism. Here, we studied the effect of the novel NOX inhibitor 2-acetylphenothiazine (2-APT) on human platelet functional responses and intracellular signaling pathways.",
"The generation of superoxide ions was as... | Taken together, our results suggest that 2-APT attenuates GPVI-specific signalling and is a novel inhibitor of collagen-induced platelet responses. Therefore, NOXs could represent a novel target for the discovery of anti-thrombotic drugs. | yes |
22,888,794 | Does long-term oxytocin administration improve social behaviors in a girl with autistic disorder? | {
"contexts": [
"Patients with autism spectrum disorders (ASDs) exhibit core autistic symptoms including social impairments from early childhood and mostly show secondary disabilities such as irritability and aggressive behavior based on core symptoms. However, there are still no radical treatments of social impa... | This case is the first to illustrate long-term administration of oxytocin nasal spray in the targeted treatment of social impairments in a female with autistic disorder. This case suggests that long-term nasal oxytocin spray is promising and well-tolerated for treatment of social impairments of patients with ASDs. | yes |
22,906,101 | Are cartilage oligomeric matrix protein specific antibodies pathogenic? | {
"contexts": [
"Cartilage oligomeric matrix protein (COMP) is a major non-collagenous component of cartilage. Earlier, we developed a new mouse model for rheumatoid arthritis using COMP. This study was undertaken to investigate the epitope specificity and immunopathogenicity of COMP-specific monoclonal antibodie... | We have identified the specificities of mAbs to COMP and their contribution to the development of arthritis. These findings will further improve our understanding of the autoantibody mediated immunopathologies occurring widely in rheumatoid arthritis (RA), as well as in other autoimmune disorders. | yes |
22,898,711 | Is abnormal glucose metabolism associated with reduced left ventricular contractile reserve and exercise intolerance in patients with chronic heart failure? | {
"contexts": [
"To investigate the associations between glucose metabolism, left ventricular (LV) contractile reserve, and exercise capacity in patients with chronic systolic heart failure (HF).",
"From an outpatient HF clinic, 161 patients with systolic HF were included (mean age 70 ± 10 years, 69% male, 59... | Diabetes, known or newly detected by OGTT, is independently associated with reduced LV contractile reserve and exercise intolerance in outpatients with systolic HF. These findings may offer one explanation for the excess mortality related to diabetes in HF. | yes |
22,884,656 | Are expression of matrix macromolecules and functional properties of breast cancer cells modulated by the bisphosphonate zoledronic acid? | {
"contexts": [
"The extracellular matrix (ECM) components play key roles in the multistep process of cancer growth and progression. Preclinical and clinical data show that bisphosphonates (BPs) may exert direct or indirect antitumoral effects. Despite proven efficiency in cancer treatment, the mechanism by which... | The obtained results demonstrate that zoledronate is a critical modulator of ECM gene expression and powerful anticancer agent inhibiting growth, migration and the matrix-associated invasion of breast cancer cells. | yes |
22,892,032 | Does microbeam-irradiated tumour tissue possess a different infrared absorbance profile compared to broad beam and sham-irradiated tissue? | {
"contexts": [
"To investigate biochemical changes in mouse tumour tissue following Microbeam Radiation Therapy (MRT) and Broad Beam (BB) irradiation using synchrotron Fourier-Transform Infrared (FTIR) microspectroscopy.",
"Synchrotron FTIR microspectroscopy was carried out on mouse tumour sections previousl... | The lack of difference between MRT peak and valley irradiated areas suggests a holistic tissue response to MRT that occurs within 4 h, and might be the first evidence for a mechanism by which MRT kills the whole tumour despite only a small percentage receiving peak irradiation. | yes |
22,885,407 | Does digital music exposure reliably induce temporary threshold shift in normal-hearing human subjects? | {
"contexts": [
"One of the challenges for evaluating new otoprotective agents for potential benefit in human populations is the availability of an established clinical paradigm with real-world relevance. These studies were explicitly designed to develop a real-world digital music exposure that reliably induces t... | These data provide insight into the variability of TTS induced by music-player use in a healthy, normal-hearing, young adult population, with music playlist, level, and duration carefully controlled. These data confirm the likelihood of temporary changes in auditory function after digital music-player use. Such data ar... | yes |
22,882,180 | Are specific histological abnormalities more likely in biopsies of endoscopically normal large bowel after the age of 60 years? | {
"contexts": [
"Colonic and rectal biopsies, often taken from an endoscopically normal large bowel, form a significant proportion of the histopathology workload. The aim of this study was to determine diagnostic yield from mucosal biopsies in patients with normal colonoscopy or sigmoidoscopy, and whether or not ... | Biopsy of an endoscopically normal large bowel, and of the normal terminal ileum in isolation, yields little abnormal histology. Diarrhoea per se does not identify patients at higher risk of abnormal histology. Increased age, however, does, and mucosal biopsy in the endoscopically normal colon and rectum may be more co... | yes |
22,890,512 | Does long-term eculizumab improve clinical outcomes in atypical hemolytic uremic syndrome? | {
"contexts": [
"Atypical hemolytic uremic syndrome (aHUS) is a rare genetic disorder caused by chronic uncontrolled complement activation.",
"We present a 4-year-old girl with aHUS who had multiple severe clinical manifestations of thrombotic microangiopathy (TMA) including acute kidney injury, dilated cardi... | Chronic eculizumab treatment was associated with control of complement-mediated TMA and sustained long-term improvement in renal and cardiac function. | yes |
22,903,876 | Does the novel orally active guanylhydrazone CPSI-2364 prevent postoperative ileus in mice independently of anti-inflammatory vagus nerve signaling? | {
"contexts": [
"Postoperative ileus (POI) is an iatrogenic complication of abdominal surgery, mediated by a severe inflammation of the muscularis externa (ME). Previously, we demonstrated that intravenous application of the tetravalent guanylhydrazone semapimod (CNI-1493) prevents POI, but the underlying mode of... | Orally administered CPSI-2364 shows a near-exclusive dispersal in the gastrointestinal tract and effectively reduces POI independently of central vagus nerve stimulation. Its efficacy after single oral dosage affirms CPSI-2364 treatment as a promising strategy for prophylaxis of POI. | yes |
22,909,578 | Is dietary salt intake related to inflammation and albuminuria in primary hypertensive patients? | {
"contexts": [
"In this study, we hypothesized that dietary salt intake may be related with inflammation and albuminuria independently from blood pressure (BP) in non-diabetic hypertensive patients.",
"A total of 224 patients with primary hypertension were included in the study. Serum C-reactive protein (CRP... | These findings suggest that high salt intake is associated with enhanced inflammation and target organ damage reflected by increased albuminuria in treated hypertensive patients independent of any BP effect. | yes |
22,907,339 | Does increased electroencephalographic gamma activity reveal awakening from isoflurane anaesthesia in rats? | {
"contexts": [
"Animal studies often require reliable measures for anaesthetic drug effects. Lately, EEG-based depth of anaesthesia estimation has been widely applied to rat models. This study investigated the reliability of different EEG spectral properties in revealing awakening from isoflurane anaesthesia in ... | The increase in frontal relative gamma activity, especially in the 50-150 Hz frequency band, seems to be the most reliable EEG indicator for the awakening of a rat from isoflurane anaesthesia. A number of other spectral measures can also be used to detect this event. However, the role of gamma frequencies in the perfor... | yes |
22,907,649 | Does the prevalence and correlate of habitual snoring during pregnancy? | {
"contexts": [
"Mounting evidence implicate habitual snoring, a prominent symptom of sleep-disordered breathing, as an important risk factor for adverse pregnancy outcomes including preeclampsia and gestational diabetes. Little, however, is known about the determinants of habitual snoring among pregnant women. W... | Identification of risk factors for habitual snoring during pregnancy has important implications for developing strategies aimed at reducing the prevalence of sleep-disordered breathing, promoting improved sleep hygiene and improved pregnancy outcomes among reproductive-age women. | yes |
22,879,370 | Does targeting mannose-binding lectin confer long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia? | {
"contexts": [
"The involvement of the complement system in brain injury has been scarcely investigated. Here, we document the pivotal role of mannose-binding lectin (MBL), one of the recognition molecules of the lectin complement pathway, in brain ischemic injury.",
"Focal cerebral ischemia was induced in m... | Our data show an important role for MBL in the pathogenesis of brain ischemic injury and provide a strong support to the concept that MBL inhibition may be a relevant therapeutic target in humans, one with a wide therapeutic window of application. | yes |
22,902,014 | Is priapism associated with sleep hypoxemia in sickle cell disease? | {
"contexts": [
"We assessed penile rigidity during sleep and the relationship of sleep abnormalities with priapism in adults with sickle cell disease.",
"This was a case-control study of 18 patients with sickle cell disease and a history of priapism during the previous year, and 16 controls with sickle cell ... | Oxyhemoglobin desaturation during sleep was associated with priapism history. It may underlie the distribution pattern of penile rigidity events during sleep in these patients. | yes |
22,884,915 | Does curcumin 's pre-incubation temperature affect its inhibitory potency toward amyloid fibrillation and fibril-induced cytotoxicity of lysozyme? | {
"contexts": [
"More than twenty-seven human proteins can fold abnormally to form amyloid deposits associated with a number of degenerative diseases. The research reported here is aimed at exploring the connection between curcumin's thermostability and its inhibitory activity toward the amyloid fibrillation of h... | The addition of thermally pre-treated curcumin was found to attenuate the formation of HEWL fibrils and the observed fibrillation inhibition was dependent upon the pre-incubation temperature of curcumin. Our results also demonstrated that the cytotoxic effects of fibrillar HEWL species on PC 12 and SH-SY5Y cells were d... | yes |
22,903,766 | Does adenoviremia have limited clinical impact in the majority of patients following alemtuzumab-based allogeneic stem cell transplantation in adults? | {
"contexts": [
"Adenovirus infection is a potentially serious complication of allogeneic hematopoietic stem cell transplantation (HSCT) and has been reported to occur more frequently following T-cell-depleted reduced-intensity HSCT. However, the true incidence and clinical significance as well as the relationshi... | We detected adenoviremia at quantifiable levels in only 12.1% of HSCT patients. Attributable mortality was low (0.9% of the entire cohort, 7% of those with adenoviremia) because even infections associated with high viral titers responded to reduction in immunosuppression and treatment with cidofovir in the majority. Th... | yes |
22,878,701 | Is apolipoprotein B-48 to triglyceride ratio a novel and useful marker for detection of type III hyperlipidemia after antihyperlipidemic intervention? | {
"contexts": [
"Remnant lipoproteins are atherogenic and are accumulated in patients with type III hyperlipidemia (HL). Although type III HL is diagnosed by phenotyping apolipoprotein (apo) E, this procedure is time-consuming and inconvenient for routine clinical use. Clinical indices for screening type III HL i... | The apo B-48/TG ratio is a novel and useful marker for detecting type III HL even after the initiation of lipid-lowering interventions. | yes |
22,882,925 | Are gender differences associated with the clinical features of systemic lupus erythematosus? | {
"contexts": [
"Systemic lupus erythematosus (SLE) mostly occurred in young women. This study was undertaken to investigate the different clinical characteristics of SLE between male and female patients, and to identify the sex hormone levels and clinical outcomes of different gender in SLE patients.",
"Of t... | Early recognition of risk factors and appropriate intervention are essential, which might lead to high disease activity and serious systemic damage in male SLE patients. | yes |
22,882,926 | Does exome sequencing identify compound heterozygous PKHD1 mutations as a cause of autosomal recessive polycystic kidney disease? | {
"contexts": [
"Autosomal recessive polycystic kidney disease (ARPKD) is a rare inherited disease, which is a disorder with multiple organ involvement, mainly the kidney and liver. It is caused by mutations in the PKHD1 gene. Here, we reported the clinical characteristics of a case with ARPKD and analyze the gen... | We identified that the compound heterozygous PKHD1 gene mutations are the molecular basis of the patient with ARPKD. Targeted exome sequencing is suitable for genetic diagnosis of single-gene inherited diseases like ARPKD in which the pathogenic gene is a large. | yes |
22,885,532 | Does nonfluoroscopic mapping reduce radiation exposure in ablation of atrial fibrillation? | {
"contexts": [
"Radiofrequency catheter ablation (RFCA) of atrial fibrillation is an effective and definitive treatment. The methods used to guide RFCA have evolved over the years from a purely electrophysiological approach, in which anatomical lesions were guided solely by fluoroscopy and angiographic imaging o... | A fast nonfluoroscopic electroanatomical mapping system may reduce radiation exposure in RFCA of atrial fibrillation, with preserved success rates. | yes |
22,878,848 | Are asthma beliefs associated with medication adherence in older asthmatics? | {
"contexts": [
"Empirical research and health policies on asthma have focused on children and young adults, even though asthma morbidity and mortality are higher among older asthmatics.",
"To explore the relationship of asthma-related beliefs and self-reported controller medication adherence in older asthmat... | Illness and treatment beliefs have a strong influence on self-reported medication adherence in older asthmatics. Interventions to improve medication adherence in older asthmatics by modifying illness and treatment beliefs warrant study. | yes |
22,886,419 | Does yes-associated protein regulate the hepatic response after bile duct ligation? | {
"contexts": [
"Human chronic cholestatic liver diseases are characterized by cholangiocyte proliferation, hepatocyte injury, and fibrosis. Yes-associated protein (YAP), the effector of the Hippo tumor-suppressor pathway, has been shown to play a critical role in promoting cholangiocyte and hepatocyte proliferat... | Our data suggest that YAP promotes cholangiocyte and hepatocyte proliferation and prevents parenchymal damage after cholestatic injury in mice and thus may mediate the response to cholestasis-induced human liver disease. | yes |
22,891,989 | Does evaluation of antitumor activity of Mimusops elengi leave on Ehrlich 's ascites carcinoma-treated mice? | {
"contexts": [
"Mimusops elengi (M. elengi) Linn. (Sapotaceae) has been used as a folk medicine in wound healing, and the treatment of pain, and inflammation in many parts of India.",
"The purpose of this investigation was to explore the antitumor activity of methanol extract of M. elengi (MEME) in Swiss alb... | MEME showed significant (p < .001) decrease in tumor volume, packed cell volume, and viable cell count, and increased the life span of EAC bearing mice. Hematological, biochemical profile, and in vivo antioxidant parameters were significantly restored toward normal levels in MEME-treated mice as compared to EAC control... | yes |
22,897,566 | Are sequence memory skills in Spastic Bilateral Cerebral Palsy age independent as in normally developing children? | {
"contexts": [
"To study the development of sequence memory skills in a group of participants with Spastic Bilateral Cerebral Palsy (CP) and their matched controls (TD). Sequence memory skills are defined as a blend of implicit and explicit competences that are crucial for the acquisition and consolidation of mo... | Sequence memory skills should be verified to plan therapeutic strategies. Therapeutic plans based on implicit learning (more resistant to disruption and stress) could be effective and highly advantageous for most but not for all CP children. Independently from age, many CP children could fix sequences more efficiently ... | yes |
22,906,531 | Is the Marburg I polymorphism of factor VII activating protease associated with low proteolytic and low pro-coagulant activity? | {
"contexts": [
"Factor VII activating protease (FSAP) is a plasma protease with FVII and pro-urokinase (pro-uPA) activating properties. A single nucleotide polymorphism (SNP) (Marburg I, MI) in the FSAP gene (HABP-2) leads to a low activity of the MI-FSAP towards pro-uPA, but supposedly not towards FVII and is d... | Most likely TFPI cleavage by WT-FSAP occurs in vivo and contributes to an elevated level of endogenous FVIIa. This may explain why MI-FSAP is not a clear indicator for deep vein thrombosis in population studies. The loss of the pro-fibrinolytic protective function of FSAP in carriers of the MI-SNP may account for the a... | yes |
22,902,169 | Are novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine d1 receptors? | {
"contexts": [
"Novel experiences activate the brain's reward system in a manner similar to drugs of abuse, and high levels of novelty-seeking and sensation-seeking behavior have been associated with increased susceptibility to alcohol and drug abuse. Here, we show that metabotropic glutamate receptor 5 (mGluR5)... | These data identify mGluR5 receptors on D1-expressing neurons as a common molecular substrate of novelty-seeking behaviors and behaviors associated with alcohol abuse. | yes |
22,897,840 | Is resistance to platinum-based chemotherapy associated with epithelial to mesenchymal transition in epithelial ovarian cancer? | {
"contexts": [
"The present study is aimed to identify genetic pathways correlated with chemoresistance in epithelial ovarian cancer (EOC).",
"We compared the molecular profiles of 23 tumour biopsies of stage III-IV (training set) at primary surgery, before chemotherapy, to the profile from the same patients... | Some genes involved in EMT were associated to overall or progression free survival, suggesting EMT as vital to the resistance mechanisms. | yes |
22,907,692 | Is body fat associated with increased and lean mass with decreased knee cartilage loss in older adults : a prospective cohort study? | {
"contexts": [
"To determine the associations between body composition at baseline and knee cartilage loss over 2.9 years in older adults.",
"A total of 395 randomly selected subjects (mean 62 years, range 51-81, 50% female) were studied at baseline and 2.9 years later. T1-weighted fat-suppressed magnetic re... | Body fat adversely affects tibial cartilage loss over time, whereas lean mass is protective. Strategies aimed at reducing body fat but increasing lean mass may reduce knee cartilage loss in older people. | yes |
22,907,691 | Does genetic variation in the vaspin gene affect circulating serum vaspin concentrations? | {
"contexts": [
"Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipokine potentially linking obesity, insulin resistance and type 2 diabetes. Here, we searched for genetic determinants that could explain the variability in serum vaspin concentrations.",
"First, we conducted a genome... | Our data show that the variability in serum vaspin concentrations might be explained by its genetic variants. | yes |
22,907,695 | Does quantitative analysis of light-phase restricted feeding reveal metabolic dyssynchrony in mice? | {
"contexts": [
"Considerable evidence suggests that the time of day at which calories are consumed markedly impacts body weight gain and adiposity. However, a precise quantification of energy balance parameters during controlled animal studies enforcing time-of-day-restricted feeding is currently lacking in the ... | Collectively, these data suggest that weight gain following light (sleep)-phase restricted feeding is associated with significant alterations in energy balance, as well as dyssynchrony between metabolically active organs. | yes |
22,901,124 | Does neurotrophic artemin promote motility and invasiveness of MIA PaCa-2 pancreatic cancer cells? | {
"contexts": [
"To analyze the capacity of neurotrophic artemin to promote the motility and invasiveness of MIA PaCa-2 pancreatic cancer cells.",
"MIA PaCa-2 was cultured in vitro and studied using transwell chambers for motility and invasiveness on treatment with different concentrations of aArtemin or its ... | Artemin and its receptor GFRα3 can promote pancreatic cancer cell motility and invasiveness and contribute to aggressive behavior. The mechanism may be related to increased expression of MMP-2 molecule and down-regulation of E-cadherin expression. | yes |
22,885,782 | Does torsional anomalous retinal correspondence effectively expand the visual field in hemianopia? | {
"contexts": [
"Exotropia in congenital homonymous hemianopia has been reported to provide field expansion that is more useful when accompanied with harmonious anomalous retinal correspondence (HARC). Torsional strabismus with HARC provides a similar functional advantage. In a subject with hemianopia demonstrati... | Torsional strabismus with anomalous retinal correspondence, when occurring with homonymous hemianopia provides useful field expansion in the lower and upper fields. Dichoptic perimetry permits documentation of ocular alignment (lateral, vertical, and torsional) and perceived visual direction under binocular and monocul... | yes |
22,885,130 | Are src and Syk targeted to an anti-inflammatory ethanol extract of Aralia continentalis? | {
"contexts": [
"Aralia continentalis Kitagawa (Araliaceae) is a representative ethnomedicinal herbal plant traditionally prescribed in Korea to relieve various inflammatory symptoms. However, the exact molecular mechanism of its anti-inflammatory activity has not been fully investigated.",
"The effect of the... | Ac-EE may be developed as a functional herbal remedy targeting Syk- and Src-mediated anti-inflammatory mechanisms. Future work using pre-clinical studies will be needed to investigate this possibility. | yes |
22,884,007 | Does postnatal depression mediate the relationship between infant and maternal sleep disruption and family dysfunction? | {
"contexts": [
"Previous research has linked family sleep disruption and dysfunction in children; however, the mechanism is unknown.",
"This study examined whether maternal sleep and postnatal depression (PND) mediate the relationship between infant sleep disruption and family dysfunction.",
"Mothers of ... | Results are consistent with the proposition that identification of both infant and maternal sleep problems during infancy can be relevant to reduction of PND and improved family functioning. | yes |
22,898,356 | Does inferring transcriptional gene regulation network of starch metabolism in Arabidopsis thaliana leave using graphical Gaussian model? | {
"contexts": [
"Starch serves as a temporal storage of carbohydrates in plant leaves during day/night cycles. To study transcriptional regulatory modules of this dynamic metabolic process, we conducted gene regulation network analysis based on small-sample inference of graphical Gaussian model (GGM).",
"Time... | In this study, we utilized a systematic approach of microarray analysis to discover the transcriptional regulatory network of starch metabolism in Arabidopsis leaves. With this inference method, the starch regulatory network of Arabidopsis was found to be strongly associated with clock genes and TFs, of which AtIDD5 an... | yes |
22,895,234 | Are aspects of culturally competent care associated with less emotional burden among patients with diabetes? | {
"contexts": [
"Diabetes distress is associated with poor diabetes self-management and worse clinical outcomes. Whether there is an association between patient experience of health care and degree of emotional burden (EB) of diabetes distress is not known.",
"To investigate whether aspects of culturally comp... | Patient report of better doctor communication behavior and higher trust in physician are inversely associated with high EB among patients with diabetes. Further research should determine whether interventions improving patient physician communication and trust can lower the EB of diabetes. | yes |
22,898,251 | Does history of weight cycling impede future weight loss or metabolic improvements in postmenopausal women? | {
"contexts": [
"Given that the repetitive loss and regain of body weight, termed weight cycling, is a prevalent phenomenon that has been associated with negative physiological and psychological outcomes, the purpose of this study was to investigate weight change and physiological outcomes in women with a lifetim... | A history of weight cycling does not impede successful participation in lifestyle interventions or alter the benefits of diet and/or exercise on body composition and metabolic outcomes. | no |
22,898,252 | Do acute hyperinsulinemia and reduced plasma free fatty acid levels decrease intramuscular triglyceride synthesis? | {
"contexts": [
"To investigate the effect of acute hyperinsulinemia and the resulting decrease in plasma free fatty acid (FFA) concentrations on intramuscular TG synthesis.",
"U-(13)C(16)-palmitate was infused for 3 h in anesthetized rabbits after overnight food deprivation. Arterial blood and leg muscle wer... | Fatty acid availability is a determinant of intramuscular TG synthesis. Insulin infusion decreases plasma and intramuscular fatty acid availability and thereby decreases TG synthesis. | yes |
22,895,372 | Are sustained and shorter bouts of physical activity related to cardiovascular health? | {
"contexts": [
"Whereas greater physical activity (PA) is known to prevent cardiovascular disease (CVD), the relative importance of performing PA in sustained bouts of activity versus shorter bouts of activity on CVD risk is not known. The objective of this study was to investigate the relationship between moder... | Our cross-sectional observations on a large middle-age community-based sample confirm a positive association of MVPA with a healthier CVD risk factor profile and indicate that accruing PA in bouts <10 min may favorably influence cardiometabolic risk. Additional investigations are warranted to confirm our findings. | yes |
22,895,376 | Is 25 ( OH ) vitamin D associated with greater muscle strength in healthy men and women? | {
"contexts": [
"The purpose of the study was to examine the relation between serum 25-hydroxy vitamin D (25(OH)D) levels and muscle strength in 419 healthy men and women over a broad age range (20-76 yr).",
"Isometric and isokinetic strength of the arms and legs was measured using computerized dynamometry, a... | These data suggest that there may be a differential effect of vitamin D on upper and lower body strength. The mechanism for this difference remains unclear but could be related to differences in androgenic effects or to differences in vitamin D receptor expression. Our study supports a direct relation between vitamin D... | yes |
22,882,558 | Is lipid profile associated with the incidence of cognitive dysfunction in viral cirrhotic patients : A data-mining analysis? | {
"contexts": [
" Cognitive dysfunction (CD) is frequently observed in cirrhotic patients. However, the biochemical profiles associated with CD remain unclear. We investigated the biochemical profiles associated with the incidence of CD in cirrhotic patients by using multivariate analyses, including a decision-t... | The levels of total bilirubin, FFA and triglycerides are independently associated with the incidence of CD in cirrhotic patients. In addition, a decision-tree algorithm revealed that FFA of more than 514 mEq/L or triglycerides of less than 106 mg/dL is a profile associated with the incidence of CD. Thus, this lipid p... | yes |
22,885,091 | Does indoxyl sulfate predict cardiovascular disease and renal function deterioration in advanced chronic kidney disease? | {
"contexts": [
"Indoxyl sulfate, a protein-bound uremic toxin, was found to be accumulated in kidney tissues with a reduction in renal function. This, in turn, not only leads to kidney fibrosis and endothelial dysfunction but also to adverse clinical effects. We investigated the adverse effects of indoxyl sulfat... | Our results suggest that serum indoxyl sulfate level was a valuable marker in predicting cardiovascular disease and renal function decline in patients with advanced chronic kidney disease. | yes |
22,901,054 | Is a corpus of full-text journal articles a robust evaluation tool for revealing differences in performance of biomedical natural language processing tools? | {
"contexts": [
"We introduce the linguistic annotation of a corpus of 97 full-text biomedical publications, known as the Colorado Richly Annotated Full Text (CRAFT) corpus. We further assess the performance of existing tools for performing sentence splitting, tokenization, syntactic parsing, and named entity rec... | The finding that some systems were able to train high-performing models based on this corpus is additional evidence, beyond high inter-annotator agreement, that the quality of the CRAFT corpus is high. The overall poor performance of various systems indicates that considerable work needs to be done to enable natural la... | yes |
22,883,963 | Does pET-CT accurately predict the pre-operative characteristics of colorectal hepatic metastases? | {
"contexts": [
"Since 2002, Positron Emission Tomography (PET-CT) has been considered to be an essential pre-operative investigation in the management of colorectal liver metastases (CRLM) in our institution. This study aimed to compare characteristics of hepatic metastases on PET-CT with post-operative histolog... | PET-CT scanning accurately detected the number of lesions and their maximum diameter, with radiological evidence of poorer differentiation. Further studies of non-surgical patients are required to assess its overall accuracy. | yes |
22,879,934 | Do relationship between swim bladder morphology and hearing abilities -- a case study on Asian and African cichlids? | {
"contexts": [
"Several teleost species have evolved anterior extensions of the swim bladder which come close to or directly contact the inner ears. A few comparative studies have shown that these morphological specializations may enhance hearing abilities. This study investigates the diversity of swim bladder m... | Our results indicate that anterior swim bladder extensions seem to improve mean absolute auditory sensitivities by 21-42 dB (SPLs) and 21-36 dB (PALs) between 0.5 and 1 kHz. Besides anterior extensions, the size of the swim bladder appears to be an important factor for extending the detectable frequency range (up to 3 ... | yes |
22,900,836 | Do influence of prophylaxis paste treatment on the abrasive wear of surface sealants? | {
"contexts": [
"To investigate the abrasive wear of surface sealants (Seal&Protect and K-0184 (experimental sealant)) and the influence of pre-treatment with mineral deposit forming prophylaxis pastes (NUPRO Sensodyne and NUPRO) on this wear.",
"One hundred and eight bovine dentine samples were randomly allo... | Stability and wear resistance of surface sealants are not affected by pre-treatment of dentine with NUPRO Sensodyne. The surface sealants tested provide a stable protective surface layer on dentine, which lasts for at least 12 000 brushing strokes. | yes |
22,879,777 | Does overexpression of human SOD1 improve survival of mice susceptible to endotoxic shock? | {
"contexts": [
"Protective effects of the antioxidant enzyme Cu-Zn superoxide dismutase (SOD1) against endotoxic shock have not been demonstrated in animal models. We used a murine model to investigate whether overexpression of SOD1 protects against endotoxic shock, and whether the genetic background of SOD1 aff... | Aberrant decrease of endogenous SOD1 activities may have overshadowed the effect of overexpression of SOD1 in tg mice (tg-JAX). Mice with C57BL/6J background (tg-TX) are more susceptible to lipopolysaccharide-induced endotoxic shock than those with mixed genetic background (tg-JAX). Overexpression of SOD1 is protective... | yes |
22,894,886 | Does bromelain limit airway inflammation in an ovalbumin-induced murine model of established asthma? | {
"contexts": [
"Allergic asthma continues to increase despite new pharmacological advances for both acute treatment and chronic-disease management. Asthma is a multifactorial disease process with genetic, allergic, infectious, environmental, and dietary origins. Researchers are investigating the benefits of life... | The results suggest that bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms. | yes |
22,898,080 | Does overexpression of WW domain-containing oxidoreductase WOX1 preferentially induce apoptosis in human glioblastoma cells harboring mutant p53? | {
"contexts": [
"Human WWOX gene encoding WW domain-containing oxidoreductase, named WWOX, FOR, or WOX1, has been studied in various types of cancer cells and shown to be a tumor suppressor with pro-apoptotic properties. Mutation or gain-of-function of p53 in glioma cells is associated with resistance to radiatio... | Overexpression of WOX1 preferentially inhibited viability and induced apoptosis in human glioblastoma cells expressing mutant p53 via a mechanism independent of the intrinsic apoptotic pathway. Conceivably, the survival of human glioblastoma cells depends upon interactions between the gain-of-function of p53 and WOX1. ... | yes |
22,890,250 | Does mild hypothermia decrease arrhythmia susceptibility in a canine model of global myocardial ischemia*? | {
"contexts": [
"Although the majority of sudden cardiac arrests occur in patients with ischemic heart disease, the effect of therapeutic hypothermia on arrhythmia susceptibility during acute global ischemia is not well understood. While both ischemia and severe hypothermia are arrhythmogenic, patients undergoing... | Mild hypothermia attenuated ischemia-induced increase in dispersion of repolarization, conduction slowing, and block, which are known mechanisms of arrhythmogenesis in ischemia. These data suggest that therapeutic hypothermia may decrease arrhythmogenesis during myocardial ischemia. | yes |
22,890,257 | Does ventilation with `` clinically relevant '' high tidal volumes promote stretch-induced injury in the lungs of healthy mice? | {
"contexts": [
"Ventilator-induced lung injury is a crucial determinant of the outcome of mechanically ventilated patients. Increasing numbers of mouse studies have identified numerous pathways and mediators that are modulated by ventilation, but it is conceptually difficult to reconcile these into a single para... | Tidal volumes up to 20 mL/kg are unlikely to induce substantial lung overstretch in models using healthy, young mice. Signs of injury/inflammation using such models are likely to result from other factors, particularly alveolar derecruitment and atelectasis. The results of such studies may need to be reevaluated before... | no |
22,902,918 | Are variants in DENND1A and LHCGR associated with endometrioid adenocarcinoma? | {
"contexts": [
"The aim of this study was to explore the polycystic ovary syndrome (PCOS) related single nucleotide polymorphisms (SNPs) rs13405728 (in gene LHCGR), rs13429458 (in gene THADA) and rs2479106 (in gene DENND1A) in women with endometrial carcinoma.",
"We conducted a case-control study comprising ... | Our results suggest that SNPs rs2479106 in gene DENND1A and rs13405728 in gene LHCGR are associated with endometrioid adenocarcinoma. | yes |
22,907,160 | Does chikungunya virus induce a more moderate cytopathic effect in mosquito cells than in mammalian cells? | {
"contexts": [
"Chikungunya virus (CHIKV) is an alphavirus belonging to the Togaviridae family. Alphaviruses cause a chronic non-cytopathic infection in mosquito cells, while they develop a highly cytopathic infection in cells originating from various vertebrates. In this study, we compared the cytopathic effect... | The reason CHIKV induced strong CPE is that this virus triggers strong apoptosis in Vero cells compared with C6/36 cells. CHIKV established a persistent infection in C6/36 cells after being passaged 20 times. CHIKV infection in mosquito cells was distinct from that in Vero cells. The cell and species specificity of CHI... | yes |
22,907,167 | Are amino acid substitutions in the hepatitis C Virus core region and lipid metabolism associated with hepatocarcinogenesis in nonresponders to interferon plus ribavirin combination therapy? | {
"contexts": [
"Substitution of amino acid 70 and/or 91 in the core region of hepatitis C virus (HCV) genotype 1b (HCV-1b) is an important predictor of hepatocellular carcinoma (HCC), but its impact on HCC in nonresponders to interferon (IFN) and ribavirin (RIB) combination therapy is not clear.",
"A total o... | Amino acid substitution in the core region of HCV-1b and low serum levels of high-density lipoprotein cholesterol are significant and independent predictors of HCC in nonresponders to IFN+RIB combination therapy. These results emphasize the importance of viral and lipid metabolic factors in the development of HCC after... | yes |
22,900,908 | Are peptic ulcer disease and heart disease associated with periprosthetic fractures after total hip replacement? | {
"contexts": [
"There have been no published studies assessing the possible association of medical comorbidities with periprosthetic fracture risk. We therefore assessed whether medical comorbidity is associated with risk of periprosthetic fractures after total hip replacement (THR).",
"We used prospectively... | Peptic ulcer disease and heart disease in primary THR patients and peptic ulcer disease in revision THR patients were associated with higher postoperative periprosthetic fracture risk. Further studies are needed to understand whether disease severity or specific medications used for treatment, or both, are responsible ... | yes |
22,904,101 | Does the blocking of CXCR3 and CCR5 suppress the infiltration of T lymphocytes in rat renal ischemia reperfusion? | {
"contexts": [
"Recent studies have identified T cells and natural killer T (NKT) cells as important mediators in renal ischemia-reperfusion (I/R) injury. The recruitment of these cells is induced by chemotaxis factors. We investigated the effects of blocking CXCR3 and CCR5 by an antagonist (TAK) using a rat ren... | These findings suggest that the blocking of CXCR3 and CCR5 suppress the infiltration of T cells and NKT cells and have a protective effect on kidneys that are injured by I/R. | yes |
22,904,105 | Does intracerebral CpG immunotherapy with carbon nanotubes abrogate growth of subcutaneous melanomas in mice? | {
"contexts": [
"Recently, we showed that intratumoral delivery of low-dose, immunostimulatory CpG oligodeoxynucleotides conjugated with carbon nanotubes (CNT-CpG) was more effective than free CpG and not only eradicated intracranial (i.c.) gliomas but also induced antitumor immunity that protected mice from subs... | These findings suggest that intracerebral CNT-CpG immunotherapy is more effective than systemic therapy in generating antitumor responses that target both brain and systemic melanomas. | yes |
22,906,665 | Does pudendal nerve stretch reduce external urethral sphincter activity in rats? | {
"contexts": [
"Most animal models of stress urinary incontinence simulate maternal injuries of childbirth since delivery is a major risk factor but they do not reproduce the nerve stretch known to occur during human childbirth. We hypothesized that pudendal nerve stretch produces reversible dysfunction of the e... | Acute pudendal nerve stretch produces reversible electrophysiological dysfunction but without leak point pressure impairment. Pudendal nerve stretch shows promise in modeling injury. It should be tested as part of a multi-injury, chronic, physiological model of human childbirth injury. | yes |
22,906,664 | Does targeting androgen receptor lead to suppression of prostate cancer via induction of autophagy? | {
"contexts": [
"Androgen receptor has a critical role in prostate cancer development and progression. Cell death via autophagy may also contribute to prostate cancer progression. We determined the role and regulatory effects of androgen receptor on the autophagy process of prostate cancer cells.",
"Using a s... | Findings provide evidence that the androgen receptor might promote prostate cancer cell growth via autophagy down-regulation. Targeting the androgen receptor via ASC-J9 might lead to tumor suppression via the induction of autophagy. This may represent a new, potential therapeutic approach and mechanism for prostate can... | yes |
22,894,638 | Does adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protect cortical neurons against excitotoxicity? | {
"contexts": [
"Neuroprotective and neurotrophic properties of leukemia inhibitory factor (LIF) have been widely reported. In the central nervous system (CNS), astrocytes are the major source for LIF, expression of which is enhanced following disturbances leading to neuronal damage. How astrocytic LIF expression... | Adenosine from glutamate-stressed neurons induces rapid LIF release in astrocytes. This rapid release of LIF promotes the survival of cortical neurons against excitotoxicity. | yes |
22,898,637 | Is the actin binding protein destrin associated with growth and perineural invasion of pancreatic cancer? | {
"contexts": [
"The small actin-binding protein destrin is one of the key regulators involved in remodeling of the actin cytoskeleton, a process crucial for cytokinesis, cell migration and polarized cell growth as well as for cancer cell migration and invasion.",
"A novel ex vivo nerve invasion model mirrori... | Destrin is upregulated in nerve-invasive pancreatic cancer cells and its expression might be related to perineural invasiveness. | yes |
22,895,826 | Is invasive pulmonary aspergillosis a frequent complication of critically ill H1N1 patients : a retrospective study? | {
"contexts": [
"Despite their controversial role, corticosteroids (CS) are frequently administered to patients with H1N1 virus infection with severe respiratory failure secondary to viral pneumonia. We hypothesized that invasive pulmonary aspergillosis (IPA) is a frequent complication in critically ill patients ... | IPA was diagnosed in 23 % of critically ill patients with H1N1 virus infection after a median of 3 days after ICU admission. Our data suggest that use of CS 7 days before ICU admission is an independent risk factor for fungal superinfection. These findings may have consequences for clinical practice as they point out t... | yes |
22,884,187 | Does functional progressive resistance training improve muscle strength but not walking ability in children with cerebral palsy? | {
"contexts": [
"Does functional progressive resistance exercise (PRE) improve walking ability and participation in school-aged children with cerebral palsy (CP)?",
"Randomised, controlled trial with concealed allocation and blinded outcome assessment.",
"Three special schools for children with physical d... | A 12-week functional PRE program improved muscle strength, but did not improve functional walking activity in school-aged ambulatory children with CP. | yes |
22,892,362 | Is the mean apparent diffusion coefficient value ( ADCmean ) on primary cervical cancer a predictive marker for disease recurrence? | {
"contexts": [
"The purpose of this study is to investigate the correlation of the max, mean and minimal apparent diffusion coefficient values (ADCmax, ADCmean, and ADCmin) on diffusion weighted imaging findings with prognostic factors in cervical cancer.",
"A cohort of 80 cervical cancer patients underwent ... | The ADCmean of primary cervical cancer calculated by MRI could be an important factor for identifying patients with a risk of disease recurrence. | yes |
22,882,727 | Does cYP7A1 polymorphism influence the LDL cholesterol-lowering response to atorvastatin? | {
"contexts": [
"Response to the lipid-lowering effect of the statins is known to show significant inter-individual variability. Our aim was to investigate whether genetic variants of the CYP3A5 gene, CYP7A1 gene and ABCG8 gene influence the lipid-lowering response to atorvastatin.",
"One hundred and seven un... | CYP7A1 gene polymorphism influences the LDL-lowering effects of atorvastatin in Chinese Hans. If replicated by others, identification of the tagged functional variant would be needed. | yes |
22,882,725 | Is utilization of intravenous thrombolysis increasing in the United States? | {
"contexts": [
"Evaluating recombinant tissue plasminogen activator utilization rates is important, as many studies have demonstrated that administration of recombinant tissue plasminogen activator to qualified patients significantly improves prognosis.",
"We investigated recent trends in the utilization and... | Intravenous recombinant tissue plasminogen activator utilization rates increased between 2001 and 2008. Advanced age and atrial fibrillation were significantly associated with increased morbidity and mortality among patients treated with intravenous recombinant tissue plasminogen activator. | yes |
22,884,185 | Are re-sprains during the first 3 months after initial ankle sprain related to incomplete recovery : an observational study? | {
"contexts": [
"What are prognostic factors for incomplete recovery, instability, re-sprains and pain intensity 12 months after patients consult primary care practitioners for acute ankle sprains?",
"Observational study.",
"One hundred and two patients who consulted their general practitioner or an emerg... | A physical examination at 3 months follow-up for the non-recovered ankle sprain patient seems to have no additional value for predicting outcome at 12 months. However, for the non-recovered patients at 3 months follow-up, self-reported pain at rest and re-sprains during the first 3 months of follow-up seem to have a pr... | yes |
22,884,184 | Do dynamic splints reduce contracture following distal radial fracture : a randomised controlled trial? | {
"contexts": [
"Do dynamic splints reduce contracture following distal radial fracture?",
"Assessor-blinded, randomised controlled trial.",
"Forty outpatients with contracture following distal radial fracture.",
"The control group received routine care consisting of exercises and advice for 8 weeks. ... | It is unclear whether dynamic splints following distal radial fracture have therapeutic effects on passive wrist extension or PRHWE, but they clearly do not have any therapeutic effects on active wrist extension, flexion, radial or ulnar deviation, or on the performance or satisfaction items of the COPM. The ongoing us... | no |
22,884,188 | Does a 12-week exercise program performed during the second trimester prevent gestational diabetes in healthy pregnant women? | {
"contexts": [
"Does a 12-week exercise program prevent gestational diabetes and improve insulin resistance in healthy pregnant women with normal body mass index (BMI)?",
"Randomised, controlled trial with concealed allocation and blinded outcome assessment.",
"Two University hospitals in Norway.",
"... | A 12-week exercise program undertaken during the second trimester of pregnancy did not reduce the prevalence of gestational diabetes in pregnant women with BMI in the normal range. | no |
22,884,949 | Do blood drug concentrations of benzodiazepines correlate poorly with actual driving impairment? | {
"contexts": [
"The use of benzodiazepine receptor agonists can significantly impair driving performance. The aim of this review was to determine if there is a relation between blood concentrations of these drugs and the degree of driving impairment.",
"A literature search was conducted to identify driving s... | While group mean average ΔSDLP and blood drug concentration sometimes correlate, individual differences in blood drug concentrations of benzodiazepine receptor agonists correlate poorly with driving impairment. From the currently available data, it must be concluded that there are no significant relationships between i... | yes |
22,890,824 | Does interleukin-15 play an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse? | {
"contexts": [
"IL-15, induced by innate immune stimuli, promotes rheumatoid arthritis and inflammatory bowel disease. However, its role in autoimmune type 1 diabetes is unclear. Our aim is to define the role of IL-15 in the pathogenesis of diabetes in the NOD mouse model.",
"We generated NOD.Il15(-/-) mice ... | Our results show that IL-15 is needed for the initial activation of diabetogenic CD8(+) T cells as well as for sustaining the diabetogenic potential of antigen-stimulated cells, acting on both CD8(+) T cells and on APCs. Our findings demonstrate a critical role for IL-15 in the pathogenesis of autoimmune diabetes and s... | yes |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.