pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
values |
|---|---|---|---|---|
22,904,330 | Is iCAM-1 K469E polymorphism a genetic determinant for the clinical risk factors of T2D subjects with retinopathy in Indians : a population-based case-control study? | {
"contexts": [
"Elevated levels of intercellular adhesion molecule-1 (ICAM-1) are demonstrated in diabetes complications. The current study aims to understand association of K469E (rs5498) in ICAM-1 gene, in type 2 diabetic (T2D) subjects with retinopathy.",
"Case-control study.",
"Sankara Nethralaya Dia... | This study shows that allele A of rs5498 in ICAM-1 is a putative risk predisposing allele for T2D retinopathy and its clinical covariates in Indian population. The folding rate of the protein decreases for the A allele implicating a potential effect on the structure and function of ICAM-1. | yes |
22,878,857 | Does pain adversely affect outcomes to a collaborative care intervention for anxiety in primary care? | {
"contexts": [
"Primary care patients with Panic Disorder (PD) and Generalized Anxiety Disorder (GAD) experience poorer than expected clinical outcomes, despite the availability of efficacious pharmacologic and non-pharmacologic treatments. A barrier to recovery from PD/GAD may be the co-occurrence of pain.",
... | Coexisting pain was common in a sample of primary care patients with severe PD/GAD, and appeared to negatively affect response to anxiety treatment. | yes |
22,884,586 | Does transvaginal Prolift ( ® ) mesh surgery due to advanced pelvic organ prolapse impair female sexual function : a prospective study? | {
"contexts": [
"To evaluate sexual function among women with advanced pelvic organ prolapse (POP) before and after Prolift(®) vaginal reconstructive mesh surgery.",
"Assessments were performed preoperatively and 12-18 months after the surgery, including physical examination using the Pelvic Organ Prolapse Qu... | Surgical treatment of advanced POP with the Prolift(®) system does not negatively influence sexual function, but patients should not expect a significant improvement after this type of operation. Additionally performed surgical restoration of perineal body does not reduce sexual function, either. | no |
22,902,396 | Is the nuclear factor-kB functional promoter polymorphism associated with endometriosis and infertility? | {
"contexts": [
"An aberrant immunologic mechanism has been suggested to be involved in the pathogenesis of endometriosis. Nuclear factor-kB (NF-kB) plays a key role in the immune and inflammatory response and modulates cell proliferation, apoptosis, adhesion, invasion, and angiogenesis in many cell types involve... | In the population sample studied, the -94 insertion/deletion ATTG polymorphism in the NFKB1 gene was positively associated both with moderate/severe endometriosis and idiopathic infertility. | yes |
22,890,154 | Does tacrolimus induce glomerular injury via endothelial dysfunction caused by reactive oxygen species and inflammatory change? | {
"contexts": [
"The immunosuppressive drug tacrolimus (FK506) is used clinically to reduce the rejection rate in patients with kidney transplantation; however, the resultant nephrotoxicity remains a serious problem. In the present study we attempted to elucidate the mechanisms of glomerular injury induced by FK5... | These findings suggest that glomerular injury resulting from FK506 is caused by oxidative stress mediated by activation of NAD(P)H oxidase and that telmisartan exerts a renoprotective effect via antioxidative activity. | yes |
22,898,764 | Is hLA class II a factor in cardiovascular morbidity and mortality rates in patients with type 1 diabetes? | {
"contexts": [
"Patients with type 1 diabetes and kidney disease have a higher risk of cardiovascular events. HLA class II genes are expressed on infiltrated inflammatory cells and smooth-muscle cells in atherosclerotic plaques. We hypothesised that HLA class II haplotypes or genotypes might influence the risk o... | The (DR1/10)-DQB1*05:01 haplotype and the (DR1/10)-DQB1*05:01/DRB1*04:01-DQB1*03:02 genotype are independently associated with cardiovascular events and death in Finnish type 1 diabetic patients. | yes |
22,883,668 | Are [ Invasive ductal carcinomas of breast showing partial reversed cell polarity associated with lymphatic tumor spread ]? | {
"contexts": [
"To investigate the relationship between partial reversed cell polarity (PRCP) and lymphatic tumor spread in invasive ductal carcinoma (IDC), not othervise specified (NOS).",
"Immunohistochemistry (EnVision method) was used to examine the expression of epithelial membrane antigen (EMA) and the... | IDC with PRCP, similar to IMPC, is more likely to show lymphovascular invasion and nodal metastasis. Complete or partial reversal of cell polarity may play a significant role in lymphatic tumor spread. | yes |
22,895,388 | Does leptin-mediated reactive oxygen species production significantly affect primary mouse hepatocyte functions in vitro? | {
"contexts": [
"Direct and indirect effects of leptin on hepatic stellate cells (HSCs) have been documented in the literature, whereas little is known about leptin's actions on hepatocytes. Leptin mediates its profibrogenic and proinflammatory effects on HSCs in part through the production of intracellular react... | Leptin induced higher ROS levels in primary hepatocytes than in LSECs and HSCs, depending on NADPH oxidase, MEK1 and JAK2 signalling but not on the long leptin receptor isoform. Furthermore, leptin exposure did not influence primary hepatocyte functionality negatively. | no |
22,897,520 | Does hippocampal sclerosis worsen autosomal dominant nocturnal frontal lobe epilepsy ( ADNFLE ) phenotype related to CHRNB2 mutation? | {
"contexts": [
"Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is a distinct epileptic syndrome with a broad range of severity even amongst affected members of the same pedigree, and the level of pharmacoresistance may reach 30%, close to that seen in sporadic focal epilepsies.",
"To investigate... | The results of this study illustrate that hippocampal sclerosis has offered a fertile substrate for intractable ADNFLE to develop. The present findings also highlight the importance of acquired factors that are directly relevant to the epilepsy phenotype and its severity even in monogenic epilepsies. | yes |
22,897,925 | Does combination of cilostazol and clopidogrel attenuate rat critical limb ischemia? | {
"contexts": [
"Procedural failure and untoward clinical outcomes after surgery remain problematic in critical limb ischemia (CLI) patients. This study tested a clopidogrel-cilostazol combination treatment compared with either treatment alone in attenuating CLI and improving CLI-region blood flow in rats.",
... | Combined cilostazol-clopidogrel therapy is superior to either agent alone in improving ischemia in rodent CLI. | yes |
22,909,048 | Does aPTT reagent with ellagic acid as activator show adequate lupus anticoagulant sensitivity in comparison to silica-based reagent? | {
"contexts": [
"Lupus anticoagulant (LA) is an antibody that interferes with phospholipid-dependent coagulation reactions. Activated partial thromboplastin time (APTT) is widely used as a test for LA screening. APTT reagents are composed of activators, such as silica or ellagic acid, and phospholipids, and APTT ... | Our results showed that the ellagic acid-based reagent was more sensitive to LA than silica-based reagents in a low phospholipid condition and had adequate sensitivity to detect LA. We concluded that the sensitivity of APTT reagents for LA is dependent on phospholipid concentration and not the activator. | yes |
22,897,390 | Are cytokine gene polymorphisms associated with irritable bowel syndrome : a systematic review and meta-analysis? | {
"contexts": [
"Low-grade inflammation has been increasingly implicated in the pathophysiology of irritable bowel syndrome (IBS). Imbalances of pro- and anti-inflammatory cytokines and polymorphisms in cytokine genes have been reported in IBS; however, these findings have not been consistently observed. This may... | This meta-analysis indicates a role for IL-10 polymorphisms in IBS in general and TNF in Asian populations. Whether or not gene polymorphisms are associated with alterations in cytokine levels leading to functional effects at the level of the gut needs further investigation. | yes |
22,897,451 | Is pre-treatment compensation use a stronger correlate of measures of activity limitations than cognitive impairment? | {
"contexts": [
"This study examined the relationship between baseline compensation use, activity limitations and cognitive impairment in persons who sustained moderate-to-severe acquired brain injury.",
"Randomized controlled clinical trial.",
"A total of 22 individuals with medically documented brain in... | Results indicate that, after acquired brain injury, baseline compensation use is more strongly associated with measures of activity limitations than is cognitive impairment. | yes |
22,906,268 | Does ischaemic postconditioning rescue brain injury caused by focal ischaemia/reperfusion via attenuation of protein oxidization? | {
"contexts": [
"To investigate the effects of ischaemic postconditioning on brain injury and protein oxidization in focal ischaemia/reperfusion.",
"Adult male Wistar rats (n = 30) were randomly divided into sham-operated, ischaemia, and ischaemic postconditioning groups. Ischaemia was produced by middle cer... | Ischaemic postconditioning is an effective way of reducing the size and effects of brain infarction caused by focal ischaemia/reperfusion, possibly due to a decrease in oxidized protein levels. Decreasing protein oxidization may, therefore, be a useful target for preventing cerebral injury. | yes |
22,905,957 | Do why community members want to participate in the selection of students into medical school? | {
"contexts": [
"Medical schools around the world have established affirmative selection policies to support applicants from the populations they serve. Increasingly they are involving community members in selecting students into medical school. At Flinders University, South Australia, community involvement in th... | Given the opportunity, community members are willing participants in selecting students into medicine. Community members bring different skills and perspectives to the selection process from which they can influence the future medical workforce. | yes |
22,907,941 | Are retinol levels associated with magnetic resonance imaging outcomes in multiple sclerosis? | {
"contexts": [
"Vitamin A has immunomodulatory properties and may regulate the transcription of genes involved in remyelination.",
"To investigate the association between retinol and disease activity in multiple sclerosis (MS).",
"Cohort study of 88 relapsing-remitting MS patients, originally included in... | Serum retinol is inversely associated with simultaneous and subsequent MRI outcomes in RRMS. | yes |
22,907,940 | Are mS risk genes transcriptionally regulated in CSF leukocytes at relapse? | {
"contexts": [
"Infiltrating T-helper cells, cytotoxic T-cells, B-cells and monocytes are thought to mediate the damage to myelin, oligodendrocytes and axons in multiple sclerosis (MS), which results in progressive disability.",
"The objective of this paper is to explore gene expression profiles of leukocyte... | DNA microarray analysis is useful in identifying differently expressed genes in CSF leukocytes, which may be important in MS in vivo. Our findings suggest that many of the risk genes for MS are differently expressed in the disease-mediating leukocytes that penetrate the blood-brain barrier. | yes |
22,901,011 | Are jAK1 gene polymorphisms associated with the outcomes of hepatitis B virus infection , but not with α interferon therapy response in a Han Chinese population? | {
"contexts": [
"Janus kinase 1 (JAK1) is a key member in the interferon (IFN) signaling pathway. Recent studies suggested single-nucleotide polymorphisms (SNPs) in IFN pathway genes are associated with outcomes of hepatitis B virus (HBV) infection and response to IFNα therapy. The aim of the study is to investig... | SNPs rs4244165 and rs17127024 in JAK1 were associated with outcomes of HBV infection, but not with response to IFNα therapy. | yes |
22,895,644 | Does the index of microvascular resistance identify patients with periprocedural myocardial infarction in elective percutaneous coronary intervention? | {
"contexts": [
"This study was designed to assess whether measurement of the index of microvascular resistance (IMR) could help prospectively identify patients who develop periprocedural myocardial infarction (PPMI).",
"IMR was measured in 54 patients before and following percutaneous coronary intervention (... | Microvascular function prior to PCI is an important determinant of PPMI. Measuring IMR pre-PCI and rPIMR may allow prospective identification of patients at risk of periprocedural myocardial infarction. Future studies in a larger cohort are required to establish the predictive ability of IMR in PPMI. | yes |
22,902,735 | Is acute kidney injury associated with increased in-hospital mortality in mechanically ventilated children with trauma? | {
"contexts": [
"Acute kidney injury (AKI) is associated with significant morbidity and mortality in patients with critical illness; however, its impact on children with trauma is not fully unexplored. We hypothesized that AKI is associated with increased in-hospital mortality.",
"A retrospective review of co... | Development of AKI (injury or failure) is a significant risk factor associated with in-hospital mortality. Our study highlights the need to consider both urine output as well as creatinine-based components of the pRIFLE criteria to define AKI. | yes |
22,902,963 | Does γ-Aminobutyric acid receptor type A receptor potentiation reduce firing of neuronal assemblies in a computational cortical model? | {
"contexts": [
"The understanding of how general anesthetics act on individual cells and on global brain function has increased significantly during the last decade. What remains poorly understood is how anesthetics act at intermediate scales. Several major theories emphasize the importance of neuronal groups, s... | GABAA facilitation both directly and indirectly inhibits the ability of neurons to form groups spontaneously. A lack of group formation is consistent with some theories of anesthetic-induced loss of memory formation and consciousness. | yes |
22,901,197 | Do elevated circulating CD19+ lymphocytes predict survival advantage in patients with gastric cancer? | {
"contexts": [
"Circulating lymphocyte subsets reflect the immunological status and might therefore be a prognostic indicator in cancer patients. Our aim was to evaluate the clinical significance of circulating lymphocyte subset in gastric cancer (GC) cases.",
"A retrospective study on a prevalent cohort of ... | Circulating lymphocyte subsets in GC patients are significantly changed, and elevated CD19+ cells may predict a favorable survival. | yes |
22,901,194 | Do interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population? | {
"contexts": [
"Our objective was to evaluate the MTHFR C677T-A1298C polymorphisms in patients with breast cancer and in individuals with no history of cancer, to compare the levels of genetic damage and apoptosis under folic acid (FA) deficiency between patients and controls, and to assess associations with bre... | Associations between the combined MTHFR C677T-A1298C polymorphism and breast cancer are possible from this study. A dose of 120 nmol/L FA could enhance apoptosis in cases with MTHFR C677T-A1298C. Breast cancer individuals with the TTAC genotype may be more sensitive to the genotoxic effects of FA deficiency than contro... | yes |
22,884,447 | Does sunitinib reduce recurrent pelvic adhesions in a rabbit model? | {
"contexts": [
"Adhesions represent a major problem after abdominal and pelvic procedures. The purpose of the present study was to determine the effect of sunitinib (Sutent, SU11248), a Food and Drug Administration-approved receptor tyrosine kinase inhibitor, on recurrent pelvic adhesion formation after pelvic a... | Sunitinib treatment might be an efficacious strategy to reduce recurrent adhesion formation after pelvic procedures. | yes |
22,889,717 | Do mobile phone emissions modulate brain excitability in patients with focal epilepsy? | {
"contexts": [
"Electromagnetic fields (EMFs) emitted by mobile phones had been shown to increase cortical excitability in healthy subjects following 45 min of continuous exposure on the ipsilateral hemisphere.",
"Using Transcranial Magnetic Stimulation (TMS), the current study assessed the effects of acute ... | Present results suggest a significant interaction between the brain excitability changes induced by EMFs and the epileptic focus, which eliminated the excitability enhancing effects of EMFs evident only in the CH. | yes |
22,879,974 | Does laninamivir octanoate and artificial surfactant combination therapy significantly increase survival of mice infected with lethal influenza H1N1 Virus? | {
"contexts": [
"Patients with influenza virus infection can develop severe pneumonia and acute respiratory distress syndrome (ARDS) which have a high mortality. Influenza virus infection is treated worldwide mainly by neuraminidase inhibitors (NAIs). However, monotherapy with NAIs is insufficient for severe pneu... | Combination therapy of laninamivir octanoate with artificial surfactant reduces lethality in mice infected with influenza virus, and eventually suppresses DAD formation and preserves lung function. This combination could be effective for prevention of severe pneumonia secondary to influenza virus infection in humans, w... | yes |
22,879,971 | Is sPARC a key regulator of proliferation , apoptosis and invasion in human ovarian cancer? | {
"contexts": [
"Secreted protein acidic and rich in cysteine (SPARC), a calcium-binding matricellular glycoprotein, is implicated in the progression of many cancers. In this study, we investigated the expression and function of SPARC in ovarian cancer.",
"cDNA microarray analysis was performed to compare gen... | SPARC is overexpressed in highly invasive subclone and ovarian cancer tissues and plays an important role in ovarian cancer growth, apoptosis and metastasis. | yes |
22,879,973 | Does characterization of a human 12/15-lipoxygenase promoter variant associated with atherosclerosis identify vimentin as a promoter binding protein? | {
"contexts": [
"Sequence variation in the human 12/15 lipoxygenase (ALOX15) has been associated with atherosclerotic disease. We functionally characterized an ALOX15 promoter polymorphism, rs2255888, previously associated with carotid plaque burden.",
"We demonstrate specific in vitro and in vivo binding of ... | This study suggests that vimentin binds the ALOX15 promoter and regulates its promoter activity and protein expression. Sequence variation that results in changes in DNA conformation and vimentin binding to the promoter may be relevant to ALOX15 gene regulation. | yes |
22,900,088 | Does mRI correlate of disability in African-Americans with multiple sclerosis? | {
"contexts": [
"Multiple sclerosis (MS) in African-Americans (AAs) is characterized by more rapid disease progression and poorer response to treatment than in Caucasian-Americans (CAs). MRI provides useful and non-invasive tools to investigate the pathological substrate of clinical progression. The aim of our st... | By studying a quite large sample of well demographically and clinically matched CA and AA patients with a homogeneous MRI protocol we showed that higher lesion accumulation, rather than pronounced brain volume decrease might explain the early progress to ambulatory assistance of AAs with MS. | yes |
22,882,807 | Is emotional loneliness associated with mortality among mentally intact nursing home residents with and without cancer : a five-year follow-up study? | {
"contexts": [
"Hypothesised that sociodemographic factors and illness variables would be associated with mortality and that emotional and social loneliness measured using the Social Provisions Scale would influence mortality among nursing homes residents with cancer.",
"Studies are lacking on how emotional ... | Independent of a cancer diagnosis or not, emotional loneliness, age, education and comorbidity influenced mortality among nursing homes residents without cognitive impairment. | yes |
22,902,423 | Is pRRT2 mutated in familial and non-familial benign infantile seizures? | {
"contexts": [
"Mutations of protein-rich transmembrane protein 2 (PRRT2) were recently associated to benign familial infantile seizures (BFIS) (MIM 605751) and paroxysmal kinesigenic dyskinesias (PKD) (MIM12800).",
"To report mutations of PRRT2 in BFIS, infantile convulsions and choreoathetosis (ICCA), and ... | Our findings emphasize that PRRT2 mutations might be responsible of both BFIS and ICCA, but might be causative also for sporadic cases of benign infantile seizures. The phenotypic spectrum comprises BFIS, ICCA, and PKD. | yes |
22,897,709 | Do maxillary sinus-floor elevation with nanoporous biphasic bone graft material for early implant placement? | {
"contexts": [
"Insufficient bone height in the posterior maxilla is caused by bone atrophy after tooth extraction and continued pneumatization of the maxillary sinus. To allow for implant placement in this area, external sinus-floor elevations are performed. For this indication, the application of various bone ... | After a mean observation time of 21.45 months, the biomaterial showed good osseointegration and bone stability radiographically. Adding to this the positive histological and immunohistochemical findings, we conclude that, after a relatively short 4-month healing period, the biomaterial showed predictable results. | yes |
22,900,949 | Does reduced soluble receptor for advanced glycation end-products ( sRAGE ) scavenger capacity precede pre-eclampsia in Type 1 diabetes? | {
"contexts": [
"Increased advanced glycation end-products (AGEs) and their soluble receptors (sRAGE) have been implicated in the pathogenesis of pre-eclampsia (PE). However, this association has not been elucidated in pregnancies complicated by diabetes. We aimed to investigate the serum levels of these factors ... | In the early stages of pregnancy, lower circulating sRAGE levels, and the ratio of sRAGE to AGEs, may be associated with the subsequent development of PE in women with T1DM. | yes |
22,905,230 | Does inositol hexakisphosphate inhibit osteoclastogenesis on RAW 264.7 cells and human primary osteoclasts? | {
"contexts": [
"Inoxitol hexakisphosphate (IP6) has been found to have an important role in biomineralization and a direct effect inhibiting mineralization of osteoblasts in vitro without impairing extracellular matrix production and expression of alkaline phosphatase. IP6 has been proposed to exhibit similar ef... | Our results demonstrate that IP6 inhibits osteoclastogenesis on human PBMNC and on the RAW264.7 cell line. Thus, IP6 may represent a novel type of selective inhibitor of osteoclasts and prove useful for the treatment of osteoporosis. | yes |
22,878,551 | Does the anabolic effect of perioperative nutrition depend on the patient 's catabolic state before surgery? | {
"contexts": [
"We tested the hypothesis that the anabolic effect of hypocaloric, isonitrogenous nutrition in patients undergoing colorectal surgery depends on the patient's preoperative catabolic state.",
"Although there is evidence to suggest that total parenteral nutrition more effectively spares protein ... | We demonstrate a significant association between the degree of preoperative catabolism, the patient's age, and the anabolic effect of hypocaloric nutrition (ClinicalTrials.gov registration ID: NCT01414946). | yes |
22,880,138 | Is administration of triclabendazole safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano? | {
"contexts": [
"The Bolivian northern Altiplano is characterized by a high prevalence of Fasciola hepatica infection. In order to assess the feasibility, safety and efficacy of large-scale administration of triclabendazole as an appropriate public health measure to control morbidity associated with fascioliasis,... | Administration of triclabendazole is a feasible, safe and efficacious public health intervention in an endemic community in the Bolivian Altiplano, suggesting that preventive chemotherapy can be applied to control of fascioliasis. Further investigations are needed to define the most appropriate frequency of treatment. | yes |
22,880,134 | Does systemic preconditioning by a prolyl hydroxylase inhibitor promote prevention of skin flap necrosis via HIF-1-induced bone marrow-derived cells? | {
"contexts": [
"Local skin flaps often present with flap necrosis caused by critical disruption of the blood supply. Although animal studies demonstrate enhanced angiogenesis in ischemic tissue, no strategy for clinical application of this phenomenon has yet been defined. Hypoxia-inducible factor 1 (HIF-1) plays... | We demonstrated that transient activation of the HIF signaling pathway by a single systemic DMOG treatment upregulates not only anti-apoptotic pathways but also enhances neovascularization with concomitant increase in the numbers of bone marrow-derived progenitor cells. | yes |
22,903,282 | Do postoperative alignment and ROM affect patient satisfaction after TKA? | {
"contexts": [
"Patient satisfaction has increasingly been recognized as an important measure after total knee arthroplasty (TKA). However, we do not know yet how and why the patients are satisfied or dissatisfied with TKA.",
"We asked: (1) After TKA, how satisfied are patients and which activities were they... | Most patients did not report symptoms, but they experienced difficulty with activities of daily living after TKA. Patient satisfaction is difficult to measure, but avoiding varus alignment and achieving better ROM appear to be important for increasing satisfaction and meeting expectations. | yes |
22,904,257 | Is pomalidomide effective for prevention and treatment of experimental skin fibrosis? | {
"contexts": [
"Tissue fibrosis is a major hallmark and a leading cause of death in systemic sclerosis (SSc). Here, we investigated the antifibrotic effects of pomalidomide, an analogue of thalidomide with potent immunomodulatory effects, in preclinical models of skin fibrosis.",
"We evaluated the antifibrot... | We demonstrate for the first time that pomalidomide exerts potent antifibrotic effects in different preclinical models of skin fibrosis. These findings lend preclinical support for the clinical studies of pomalidomide in SSc. | yes |
22,905,122 | Does tungstate reduce the expression of gluconeogenic enzymes in STZ rats? | {
"contexts": [
"Oral administration of sodium tungstate has shown hyperglycemia-reducing activity in several animal models of diabetes. We present new insights into the mechanism of action of tungstate.",
"We studied protein expression and phosphorylation in the liver of STZ rats, a type I diabetes model, tr... | Here we show that treatment with tungstate restores the phosphorylation state of various signaling proteins and changes the expression pattern of metabolic enzymes. | yes |
22,883,440 | Does bilberry ingestion improve disease activity in mild to moderate ulcerative colitis - an open pilot study? | {
"contexts": [
"A significant fraction of patients with ulcerative colitis (UC) is not sufficiently controlled with conventional therapy or suffers from therapy related side effects. Anthocyanins, highly abundant in bilberries (Vaccinium myrtillus), were shown to have antioxidative and anti-inflammatory effects.... | This is the first report on the promising therapeutic potential of a standardized anthocyanin-rich bilberry preparation in UC in humans. These results clearly indicate a therapeutic potential of bilberries in UC. Further studies on mechanisms and randomized clinical trials are warranted. | yes |
22,901,402 | Do trajectories of cigarette smoking in adulthood predict insomnia among women in late mid-life? | {
"contexts": [
"To examine the relationship between trajectories of cigarette smoking among a community sample of women (N=498) with insomnia in late mid-life.",
"Participants were administered structured interviews at four time waves in adulthood, spanning approximately 25 years (mean ages=40, 43, 48, and 6... | Smoking cessation programs and clinicians treating female patients in mid-life should be aware that chronic heavy smoking in adulthood is a significant risk factor for insomnia. | yes |
22,879,518 | Is epigenetic modification of liver mitochondrial DNA associated with histological severity of nonalcoholic fatty liver disease? | {
"contexts": [
"Nonalcoholic fatty liver disease (NAFLD) is a clinical condition that refers to progressive histological changes ranging from simple steatosis (SS) to nonalcoholic steatohepatitis (NASH). We evaluated the status of cytosine methylation (5mC) of liver mitochondrial DNA (mtDNA) in selected regions ... | Hepatic methylation and transcriptional activity of the MT-ND6 are associated with the histological severity of NAFLD. Epigenetic changes of mtDNA are potentially reversible by interventional programs, as physical activity could modulate the methylation status of MT-ND6. | yes |
22,879,519 | Is the NOD2insC polymorphism associated with worse outcome following ileal pouch-anal anastomosis for ulcerative colitis? | {
"contexts": [
"Inflammatory complications after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) are common.",
"To investigate whether genetic factors are associated with adverse pouch outcomes such as chronic pouchitis (CP) and a Crohn's disease-like (CDL) phenotype.",
"866 patients were... | Genetic polymorphisms, in particular, the NOD2insC risk allele, are associated with chronic inflammatory pouch outcomes among patients with UC and IPAA. | yes |
22,880,044 | Does thymosin beta 4 protect cardiomyocytes from oxidative stress by targeting anti-oxidative enzymes and anti-apoptotic genes? | {
"contexts": [
"Thymosin beta-4 (Tβ4) is a ubiquitous protein with many properties relating to cell proliferation and differentiation that promotes wound healing and modulates inflammatory mediators. The mechanism by which Tβ4 modulates cardiac protection under oxidative stress is not known. The purpose of this ... | This is the first report that demonstrates the effect of Tβ4 on cardiomyocytes and its capability to selectively upregulate anti-oxidative enzymes, anti-inflammatory genes, and antiapoptotic enzymes in the neonatal cardiomyocytes thus preventing cell death thereby protecting the myocardium. Tβ4 treatment resulted in de... | yes |
22,904,162 | Are microRNAs related to angiogenesis dysregulated in endometrioid endometrial cancer? | {
"contexts": [
"Which is the role of microRNAs (miRNAs) related to several angiogenesis regulators such as VEGF-A (Vascular endothelial growth factor-A) and TSP-1 (Thrombospondin-1) in endometrial cancer?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Adult",
"Aged",
"Endometrial Neoplasms",... | A dysregulated expression of miRNAs related to angiogenesis and an increase in the VEGF-A levels were observed in endometrial cancer in comparison with control. The different expression of miRNAs could modulate the expression of angiogenic and antiangiogenic factors, which may play an important role in the pathogenesis... | yes |
22,901,528 | Does blockade of adenosine A2A receptors prevent interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway? | {
"contexts": [
"Blockade of adenosine A(2A) receptors (A(2A)R) affords robust neuroprotection in a number of brain conditions, although the mechanisms are still unknown. A likely candidate mechanism for this neuroprotection is the control of neuroinflammation, which contributes to the amplification of neurodegen... | These results prompt the hypothesis that the neuroprotection afforded by A(2A)R blockade might result from this particular ability of A(2A)R to control IL-1β-induced exacerbation of excitotoxic neuronal damage, through the control of MAPK activation and late calcium deregulation. | yes |
22,909,194 | Is macrophage migration inhibitory factor gene polymorphism associated with pemphigus vulgaris in Iranian patients? | {
"contexts": [
"Promoter polymorphisms of the macrophage migration inhibitory factor gene are associated with increased production of macrophage migration inhibitory factor. Elevated levels of macrophage migration inhibitory factor have been observed in the sera of patients with pemphigus vulgaris. More than thi... | The result of this study using a large and well documented trial of patients showed that macrophage migration inhibitory factor -173G-C polymorphism is not associated with pemphigus vulgaris; but as the role of macrophage migration inhibitory factor in the inflammatory process has not been delineated in detail and the ... | no |
22,909,195 | Does direct integration of intensity-level data from Affymetrix and Illumina microarrays improve statistical power for robust reanalysis? | {
"contexts": [
"Affymetrix GeneChips and Illumina BeadArrays are the most widely used commercial single channel gene expression microarrays. Public data repositories are an extremely valuable resource, providing array-derived gene expression measurements from many thousands of experiments. Unfortunately many of ... | Normalised and batch-corrected intensity-level data from Affymetrix and Illumina microarrays can be directly combined to generate biologically meaningful results with improved statistical power for robust, integrated reanalysis. | yes |
22,878,279 | Is weight gain after lung reduction surgery related to improved lung function and ventilatory efficiency? | {
"contexts": [
"Lung volume reduction surgery (LVRS) is associated with weight gain in some patients, but the group that gains weight after LVRS and the mechanisms underlying this phenomenon have not been well characterized.",
"To describe the weight change profiles of LVRS patients enrolled in the National ... | LVRS leads to weight gain in nonobese patients, which is associated with improvement in lung function, exercise capacity, respiratory muscle strength, and ventilatory efficiency. These physiological changes may be partially responsible for weight gain in patients who undergo LVRS. | yes |
22,891,969 | Is hCRP1 expression status a significant prognostic marker in oral and oropharyngeal cancer? | {
"contexts": [
"The hepatocellular carcinoma-related protein 1 (HCRP1) is a key factor in the degradation of the epidermal growth factor receptor. In this study, we assessed the prognostic significance of HCRP1 expression in patients with oral and oropharyngeal squamous cell carcinoma (OOSCC).",
"HCRP1 expre... | Low HCRP1 expression was found to be of adverse prognostic significance in patients with OOSCC who received preoperative chemoradiotherapy. | yes |
22,887,770 | Does activation of natural killer T cells ameliorate postinfarct cardiac remodeling and failure in mice? | {
"contexts": [
"Chronic inflammation in the myocardium is involved in the development of left ventricular (LV) remodeling and failure after myocardial infarction (MI). Invariant natural killer T (iNKT) cells have been shown to produce inflammatory cytokines and orchestrate tissue inflammation. However, no previo... | iNKT cells play a protective role against post-MI LV remodeling and failure through the enhanced expression of cardioprotective cytokines such as IL-10. | yes |
22,877,691 | Is poor health-related quality of life associated with long-term mortality in young adults with cerebral infarction? | {
"contexts": [
"Our aim was to investigate the effect of health-related quality of life (HRQOL) on subsequent mortality in young ischemic stroke patients in a population-based study.",
"Young ischemic stroke patients were invited to a follow-up on average 6 years after their index stroke. HRQOL was measured ... | Poor HRQOL is associated with subsequent long-term mortality in young adults with ischemic stroke and this may pertain particularly to pain, sleep disturbances and low physical fitness. | yes |
22,904,655 | Do efficiency of caries risk assessment in young adults using Cariogram? | {
"contexts": [
"THE AIMS OF THIS STUDY WERE TO: (1) evaluate the caries risk in young adults using Cariogram and (2) compare the efficiency of Cariogram with the regression risk models created using the same variables in Cariogram by examining the actual caries progression over a 2-year period.",
"This study... | Cariogram is effective and can be used for caries risk assessment instead of single variables; however, it is possible to develop simplier models with regression analyses to determine caries risk. | yes |
22,879,386 | Do lAP+CD4+ T cells are suppressors accumulated in the tumor sites and associated with the progression of colorectal cancer? | {
"contexts": [
"Suppressor T cells are one of the determinants of colorectal cancer (CRC) clinical outcome. LAP(+)CD4(+) T cell is a recently identified subset of suppressor T cells. This study was designed to investigate their clinical relevance in patients with CRC.",
"Sixty patients with CRC and 24 health... | LAP(+)CD4(+) T cells as a suppressor subset could accumulate in the tumor microenvironment and circulated more in the peripheral blood with tumor progression in patients with CRC. | yes |
22,879,389 | Does counteracting autophagy overcome resistance to everolimus in mantle cell lymphoma? | {
"contexts": [
"Mantle cell lymphoma (MCL) is an aggressive B-lymphoid neoplasm with poor response to conventional chemotherapy and short survival. The phosphatidylinositol 3-kinase/Akt/mTOR survival pathway is constitutively activated in MCL cells, thereby making the mTOR inhibition an attractive therapeutic st... | These results suggest that autophagy induction protects MCL cells from Akt/mTOR targeting and counteracting autophagy may represent an attractive strategy for sensitizing MCL cells to everolimus-based therapy. | yes |
22,900,825 | Is early infarct FLAIR hyperintensity associated with increased hemorrhagic transformation after thrombolysis? | {
"contexts": [
"Absence of FLAIR hyperintensity within an acute infarct is associated with stroke onset <4.5 h. However, some patients rapidly develop FLAIR hyperintensity within this timeframe. We hypothesized that development of early infarct FLAIR hyperintensity would predict hemorrhagic transformation (HT) i... | Early development of FLAIR hyperintensity within the area of diffusion restriction is associated with increased risk of HT after thrombolysis in acute stroke patients. | yes |
22,883,539 | Are caregiver food behaviours associated with dietary intakes of children outside the child-care setting? | {
"contexts": [
"To evaluate whether food behaviours of parents are associated with children’s dietary intakes outside the child-care setting, and to compare children’s dietary intakes at home with foods and beverages consumed when they are at child-care centres.",
"In 2005–2006, a survey was completed by par... | Children’s dietary intakes at home need to be improved. Parents need to understand the importance of providing home environments that support healthful food behaviours in children. | yes |
22,910,319 | Is post-chemotherapy T-cell recovery a marker of improved survival in patients with advanced thoracic malignancies? | {
"contexts": [
"There is increasing interest in combining chemotherapy with immunotherapy. However, the effects of chemotherapy on the human immune system are largely unknown.",
"Longitudinal changes in peripheral T-cell subsets in 40 patients with malignant mesothelioma (MM) or advanced non-small cell lung ... | Chemotherapy potentially provides a favourable environment for the development of anti-tumour immunity through transient Treg depletion and regeneration of the T-cell pool. Change in CD8(+) T-cell proliferation after one cycle of chemotherapy may represent a useful prognostic indicator in patients with MM and NSCLC. | yes |
22,899,803 | Does oritavancin induce Clostridium difficile germination and toxin production in hamsters or a human gut model? | {
"contexts": [
"To evaluate the relative propensities of oritavancin and vancomycin to induce Clostridium difficile infection (CDI) in hamster and in vitro human gut models.",
"Hamsters received clindamycin (100 mg/kg orally or subcutaneously), oritavancin (50 mg/kg orally) or vancomycin (50 mg/kg orally). C... | Oritavancin exposure, unlike exposure to vancomycin or clindamycin, did not lead to CDI in hamsters. In both models, oritavancin reduced C. difficile total counts and spores to below detectable limits. The data indicate the potential of oritavancin for CDI treatment, since exposure did not induce C. difficile germinati... | no |
22,878,679 | Does lung microenvironment contribute to the resistance of alveolar macrophages to develop tolerance to endotoxin*? | {
"contexts": [
"Endotoxin tolerance corresponds to reprogramming of mononuclear phagocytes after iterative encounters with toll-like receptor agonists aimed to dampen the inflammatory response. We investigated why this phenomenon cannot be observed with murine alveolar macrophages.",
"Animal study.",
"Re... | Our results support the conclusion that at homeostasis in the lungs, constitutive expression of granulocyte-macrophage colony-stimulating factor, interleukin-18, interferon-γ and possibly interleukin-15, and a cross-talk between B lymphocytes and alveolar macrophages create a microenvironment specific to the lungs that... | yes |
22,885,567 | Do intracellular calcium oscillations in articular chondrocytes induced by basic calcium phosphate crystals lead to cartilage degradation? | {
"contexts": [
"Basic calcium phosphate (BCP) crystals, including octacalcium phosphate (OCP), carbonated-apatite (CA) and hydroxyapatite (HA) crystals are associated with destructive forms of osteoarthritis. Mechanisms of BCP-induced cartilage breakdown remain incompletely understood. We assessed the ability of... | BCP crystals can induce variation in iCa(2+) content and oscillations in articular chondrocytes. Furthermore, BCP crystal-induced changes in iCa(2+) content play a pivotal role in BCP catabolic effects on articular cartilage. | yes |
22,893,857 | Is swiss ball abdominal crunch with added elastic resistance an effective alternative to training machines? | {
"contexts": [
"Swiss ball training is recommended as a low intensity modality to improve joint position, posture, balance, and neural feedback. However, proper training intensity is difficult to obtain during Swiss ball exercises whereas strengthening exercises on machines usually are performed to induce high l... | Crunches on a Swiss ball with added elastic resistance induces high rectus abdominis activity accompanied by low hip flexor activity which could be beneficial for individuals with low back pain. In opposition, the lower rectus abdominis activity and higher rectus femoris activity observed in machine warrant caution for... | yes |
22,884,140 | Are tumor-infiltrating regulatory T cells positively correlated with angiogenic status in renal cell carcinoma? | {
"contexts": [
"Immune cells within a tumor microenvironment have shown modulatory effects on tumor angiogenic activity. Renal cell carcinoma (RCC) is a hypervascular tumor that reportedly increases the frequency of regulatory T cells (Tregs) in tumor tissues. This study investigated the correlation between Treg... | These observations suggest that the high pro-angiogenic status of RCC may be associated with the accumulation of Tregs in the local microenvironment. Angiogenesis networks may be connected with immune tolerance units and cooperate with each other to facilitate tumor growth and progression. | yes |
22,893,673 | Is neuron-specific enolase elevated in asymptomatic carriers of Leber 's hereditary optic neuropathy? | {
"contexts": [
"Neuron-specific enolase (NSE) is a biomarker for neuronal stress. Leber's hereditary optic neuropathy (LHON) is a mitochondrial disease affecting retinal ganglion cells (RGC). These RGCs and their axons in the retinal nerve fiber layer (RNFL) and optic nerve head may show subclinical pathology in... | Serum NSE levels are higher in LHON carriers compared with affected and off-pedigree individuals. A subgroup of mostly male carriers had significantly elevated serum NSE levels. Thus, male carriers are at higher risk for LHON-related neuronal stress. | yes |
22,890,596 | Does silencing of TLR4 increase tumor progression and lung metastasis in a murine model of breast cancer? | {
"contexts": [
"Toll-like receptor 4 (TLR4) is a member of a family of pattern recognition receptors that are involved in the host defense against microbial infection. Little research has investigated the link between TLR4 and cancer. We thus addressed the effect of TLR4 in both the host immune system and cancer... | TLR4 exerts both a defensive role at the host level and a negative role at the cancer cell level in this murine metastatic breast tumor model. Further evaluation of the role of TLR4 in breast cancer is warranted. | yes |
22,904,094 | Are mitofusins 1 and 2 essential for postnatal metabolic remodeling in heart? | {
"contexts": [
"At birth, there is a switch from placental to pulmonary circulation and the heart commences its aerobic metabolism. In cardiac myocytes, this transition is marked by increased mitochondrial biogenesis and remodeling of the intracellular architecture. The mechanisms governing the formation of new ... | Our findings establish that Mfn-1 and Mfn-2 are essential in mediating mitochondrial remodeling during postnatal cardiac development, a time of dramatic transitions in the bioenergetics and growth of the heart. | yes |
22,884,268 | Does laparoscopic appendectomy for complicated acute appendicitis result in increased surgical complications? | {
"contexts": [
"Septic postoperative complications are debated in patients with complicated acute appendicitis treated with laparoscopic appendectomy (LA). The aim of this study was to investigate the results of LA in both complicated and uncomplicated cases of acute appendicitis.",
"From January to December... | This study demonstrated no increase in surgical complications after LA in patients with complicated acute appendicitis when compared with those who had uncomplicated disease. Therefore, LA may be considered the first-choice treatment option for both uncomplicated and complicated acute appendicitis. | no |
22,896,586 | Does upregulation of TRPM7 channels by angiotensin II trigger phenotypic switching of vascular smooth muscle cells of ascending aorta? | {
"contexts": [
"Angiotensin II (Ang II) has pleiotropic effects on vascular smooth muscle cells (VSMCs). It has been demonstrated to promote the proliferative phenotype of VSMCs in mouse ascending aorta, but the underlying mechanisms remain incompletely understood.",
"The present study was designed to explor... | Our data establish that upregulation of TRPM7 channels by Ang II contributes to the development of the proliferative phenotype of ascending aortic VSMCs, and TRPM7 channel suppresses VSMC gene expression via Ca(2+) influx-mediated activation of Pyk2-ERK1/2-Elk-1 pathway. | yes |
22,884,863 | Is hypercholesterolemia associated with a lower risk of cerebral ischemic small vessel disease detected on brain checkups? | {
"contexts": [
"Several studies have reported an association between low cholesterol levels and cerebral small vessel disease (SVD). In this study, we examined whether serum total cholesterol was associated with SVD, including lacunar infarctions and white matter hyperintensity, detected by magnetic resonance im... | Hypercholesterolemia was significantly associated with a lower risk of SVD, detected by MRI, in participants undergoing a brain checkup, after adjusting for potential confounding factors, such as age and hypertension. | yes |
22,891,862 | Do lipoplexes carrying mRNA encoding Gag protein modulate dendritic cells to stimulate HIV-specific immune responses? | {
"contexts": [
"Cationic lipids (Lipofectamine™ [Invitrogen, Merelbeke, Belgium] and 1,2-dioleoyl-3-trimethylammonium-propane/1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) and polymers (jetPEI™ and in vivo-jetPEI™ [Polyplus-transfection, Illkirch, France]) were evaluated for their potential to deliver mRNA to m... | Cationic lipid-mediated mRNA delivery may be a useful tool for therapeutic vaccination against HIV-1. This approach can be applied to develop vaccination strategies for other infectious diseases and cancer. | yes |
22,891,866 | Does a nano-sized PARACEST-fluorescence imaging contrast agent facilitate and validates in vivo CEST MRI detection of glioma? | {
"contexts": [
"The authors have investigated the usefulness of in vivo chemical exchange saturation transfer MRI for detecting gliomas using a dual-modality imaging contrast agent.",
"A paramagnetic chemical exchange saturation transfer MRI contrast agent, Eu-1,4,7,10-tetraazacclododecane-1,4,7,10-tetraacet... | This study demonstrated the merits of using a nano-sized imaging contrast agent for detecting gliomas and using a dual-modality agent for detecting gliomas at different spatial scales. | yes |
22,897,442 | Is apolipoprotein B a new target of the GDNF/RET and ET-3/EDNRB signalling pathways? | {
"contexts": [
"GDNF/RET and Endothelin-3 (ET-3)/EDNRB regulate survival, differentiation, migration, and proliferation of neural crest-derived cells. Although several RET and EDNRB signalling mediators have been characterized, most of the genes targeted by these two pathways are still largely unknown. We focuse... | Apob is a novel downstream target of the RET/EDNRB pathways with a role in neuronal survival and maintenance, as indicated by its effect on HuD expression. Our data provide a conceptual framework to investigate and establish the role of APOB gene in severe gut dysmotility. | yes |
22,886,496 | Does knee laxity after staircase exercise predict radiographic disease progression in medial compartment knee osteoarthritis? | {
"contexts": [
"To evaluate whether increased laxity of the knee during daily physical activities such as stair climbing is associated with progression of knee joint osteoarthritis (OA).",
"During the years 2001-2003, 136 patients with bilateral primary medial compartment knee joint OA were enrolled in this ... | Our results indicate that patients with OA progression have significantly greater changes in knee joint laxity during physical activities and a higher BMI than patients without OA progression. These findings suggest that larger changes in knee laxity during repetitive physical activities and a higher BMI play significa... | yes |
22,886,493 | Is hepatic encephalopathy associated with decreased cerebral oxygen metabolism and blood flow , not increased ammonia uptake? | {
"contexts": [
"Studies have shown decreased cerebral oxygen metabolism (CMRO(2)) and blood flow (CBF) in patients with cirrhosis with hepatic encephalopathy (HE). It remains unclear, however, whether these disturbances are associated with HE or with cirrhosis itself and how they may relate to arterial blood amm... | The low values of CMRO(2) and CBF observed during HE increased after recovery from HE and were thus associated with HE rather than the liver disease as such. The changes in CMRO(2) and CBF could not be linked to blood ammonia concentration or CMRA. | yes |
22,906,270 | Are levels of components of the urokinase-type plasminogen activator system related to chronic obstructive pulmonary disease parenchymal destruction and airway remodelling? | {
"contexts": [
"Retrospective study to investigate levels of components of the urokinase-type plasminogen activator (uPA) system in patients with chronic obstructive pulmonary disease (COPD).",
"Peripheral lung tissue was obtained from patients who underwent surgical resection for benign lung diseases: 16 pa... | Correlations between components of the uPA system and lung function, small airway fibrosis and emphysema indicate a role for the uPA system in COPD. | yes |
22,884,253 | Is glutathione S-transferase PI ( GST-PI ) mRNA expression and DNA methylation involved in the pathogenesis and prognosis of NSCLC? | {
"contexts": [
"The aim of this study was to investigate the relevance of mRNA expression and DNA methylation of GST-PI in tumor and non-tumor lung tissue from NSCLC patients in terms of prognostic and pathogenetic value of this biomarker.",
"Quantitative real-time PCR was used to measure mRNA expression and... | GST-PI mRNA expression seems to be involved in the pathogenesis of NSCLC. High levels of GST-PI DNA methylation in tumor tissue of NSCLC patients have a potential as a biomarker identifying subpopulations with a more aggressive tumor biology. Quantitation of GST-PI DNA methylation may be a useful method to identify pat... | yes |
22,898,263 | Does next-generation sequencing identify a novel compound heterozygous mutation in MYO7A in a Chinese patient with Usher Syndrome 1B? | {
"contexts": [
"Targeted enrichment and next-generation sequencing (NGS) have been employed for detection of genetic diseases. The purpose of this study was to validate the accuracy and sensitivity of our method for comprehensive mutation detection of hereditary hearing loss, and identify inherited mutations inv... | The compound heterozygosity identified in gene MYO7A causes Usher Syndrome 1B with severe phenotypes. The results support that the combination of enrichment of targeted genes and next-generation sequencing is a valuable molecular diagnostic tool for hereditary deafness and suitable for clinical application. | yes |
22,907,951 | Are growth arrest-specific gene 6 ( Gas6 ) levels elevated in patients with chronic renal failure? | {
"contexts": [
"The TAM receptors (tyro3, axl and mer) and their ligands (vitamin K-dependent proteins-Gas6 and Protein S) are crucial modulators of inflammation, which may be relevant in chronic kidney disease (CKD). Gas6 and axl have multiple roles in mediating vascular atherosclerosis and injury, thrombosis a... | Dysregulation of circulating Gas6 is associated with renal disease and inversely proportional to renal function. Low albumin and higher IV iron administration were associated with higher Gas6 levels, suggesting a possible connection between inflammation and oxidative stress mediated by iron. Protein S levels were also ... | yes |
22,902,724 | Do plasma factors during chronic HIV-1 infection impair IL-12 secretion by myeloid dendritic cells via a virus-independent pathway? | {
"contexts": [
"Myeloid dendritic cell (mDC) dysfunction during HIV infection may hinder the formation of both innate and adaptive immune responses and contribute to pathogenesis. Our objective was to determine whether circulating factors during chronic HIV infection impair mDC function with respect to secretion... | Plasma factors during chronic HIV infection impair mDC function in a manner that likely impacts the formation of immune responses to HIV, opportunistic pathogens, and vaccines. Despite partial alleviation by cART, this suppression was not directly mediated by HIV. | yes |
22,889,704 | Does upregulation of microRNA-1 and microRNA-133 contribute to arsenic-induced cardiac electrical remodeling? | {
"contexts": [
"A large body of evidence showed that arsenic trioxide (As2O3), a front-line drug for the treatment of acute promyelocytic leukemia, induced abnormal cardiac QT prolongation, which hampers its clinical use. The molecular mechanisms for this cardiotoxicity remained unclear. This study aimed to eluc... | Deregulation of miR-133 and miR-1 underlies As2O3-induced cardiac electrical disorders and these miRs may serve as potential therapeutic targets for the handling of As2O3 cardiotoxicity. | yes |
22,905,720 | Do distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner? | {
"contexts": [
"There is strong but mostly circumstantial evidence that genetic factors modulate the severity of influenza infection in humans. Using genetically diverse but fully inbred strains of mice it has been shown that host sequence variants have a strong influence on the severity of influenza A disease p... | We have mapped influenza susceptibility loci to chromosomes 2, 5, 16, 17, and 19. Body weight and survival loci have a time-dependent profile that presumably reflects the temporal dynamic of the response to infection. We highlight candidate genes in the respective intervals and review their possible biological function... | yes |
22,897,503 | Does mSQoL-54 predict change in fatigue after inpatient rehabilitation for people with multiple sclerosis? | {
"contexts": [
"The aim of our study was to investigate the impact of a short-term inpatient rehabilitation program on fatigue in patients with multiple sclerosis (MS) and to assess whether the scales of Multiple Sclerosis Quality of Life 54 (MSQoL-54) could predict change in fatigue after rehabilitation.",
... | Inpatient rehabilitation decreased MS patients' fatigue. Change in fatigue was predicted with certain domains of QoL at baseline. | yes |
22,895,020 | Does angiotensin II type 2 receptor mediate sex differences in mice renal interlobar arteries response to angiotensin II? | {
"contexts": [
"Functional sex differences are described in several vascular beds. In the case of renal vessels, sex differences could influence processes like regulation of blood pressure and ion balance. Angiotensin II and nitric oxide are important regulators of renal vascular tone. Females have higher nitric... | A sex-specific, nitric oxide-mediated effect via angiotensin II type 2 receptors underlies the sex differences in the response of interlobar arteries to angiotensin II. Our findings may help understanding sex differences in renal hemodynamics and blood pressure control. | yes |
22,900,095 | Does genome-wide screening reveal an EMT molecular network mediated by Sonic hedgehog-Gli1 signaling in pancreatic cancer cells? | {
"contexts": [
"The role of sonic hedgehog (SHH) in epithelial mesenchymal transition (EMT) of pancreatic cancer (PC) is known, however, its mechanism is unclear. Because SHH promotes tumor development predominantly through Gli1, we sought to understand its mechanism by identifying Gli1 targets in pancreatic can... | Our results suggest that targeting the molecular connections established between SHH-Gli1 signaling and EMT could provide effective therapies for PC. | yes |
22,901,367 | Does propofol induce proliferation and invasion of gallbladder cancer cells through activation of Nrf2? | {
"contexts": [
"Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but the effect of propofol on gallbladder cancer is not clear. NF-E2-related factor 2 (Nrf2) is abundantly expressed in cancer cells and relates to proliferation, invasion, and chemoresistanc... | Propofol induces proliferation and promotes invasion of GC cells through activation of Nrf2. | yes |
22,892,920 | Is renal oxygen content increased in healthy subjects after angiotensin-converting enzyme inhibition? | {
"contexts": [
"The association between renal hypoxia and the development of renal injury is well established. However, no adequate method currently exists to non-invasively measure functional changes in renal oxygenation in normal and injured patients.",
"R2* quantification was performed using renal blood o... | This result suggests that the technique efficiently measured alterations in renal blood oxygenation after angiotensin II-converting enzyme inhibition and that it may provide a new strategy for identifying the early stages of renal disease and perhaps new therapeutic targets. | yes |
22,892,928 | Does exercise training prevent diastolic dysfunction induced by metabolic syndrome in rats? | {
"contexts": [
"High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations.",
"Wistar rats receiving fructose overl... | The role of exercise training in the prevention of metabolic and hemodynamic parameter alterations is of great importance in decreasing the cardiac morbidity and mortality related to metabolic syndrome. | yes |
22,885,018 | Are arterial cord blood lutein levels in preterm and term healthy newborns sex and gestational age dependent? | {
"contexts": [
"Lutein is an antioxidant carotenoid exerting a key role in eye health, but no reference curve in the perinatal period is available.",
"We conducted a prospective study on the distribution of lutein and its metabolite 3'-oxolutein in arterial cord blood of preterm (n=40) and term (n=76) newbor... | Since macula densa and retina are sites of lutein accumulation, the present findings open-up a new cue on the potential role of lutein in the prevention of the retinopathy of prematurity. | yes |
22,895,686 | Does rotator cuff integrity correlate with clinical and functional results at a minimum 16 years after open repair? | {
"contexts": [
"Recurrent or persistent defects in the rotator cuff after its repair are common. Short- and medium-term surveys have revealed, after open repair, patients with an intact rotator cuff have increased function and ROM. However, no long-term studies have verified cuff integrity on MR arthrography or ... | Rotator cuff integrity was lost in 94% of patients after a minimum followup of 16 years. Cuff integrity correlates well with clinical and functional results even several years postoperatively. A large retear seems to be the most important factor in deteriorating long-term clinical and functional results after open rota... | yes |
22,901,988 | Does water immersion simplify cecal intubation in patients with redundant colons and previous incomplete colonoscopies? | {
"contexts": [
"Interest in effective ways to complete colon examinations in patients who had previously undergone failed colonoscopies has increased recently.",
"To determine whether water immersion decreased the need for ancillary equipment to achieve cecal intubation in patients who had previously undergo... | Retrospective review; single-center, single-endoscopist study. | yes |
22,889,954 | Does met act through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver? | {
"contexts": [
"Genetic studies indicate that distinct signaling modulators are each necessary but not individually sufficient for embryonic hepatocyte survival in vivo. Nevertheless, how signaling players are interconnected into functional circuits and how they coordinate the balance of cell survival and death ... | A signaling circuit involving Abl and p38MAPK is required downstream of Met for the survival of embryonic hepatocytes, via qualitative regulation of the p53 transcriptional response, by switching its proapoptotic into survival properties. | yes |
22,897,637 | Does red blood cell endothelial nitric oxide synthase modulate red blood cell storage hemolysis? | {
"contexts": [
"The red blood cell (RBC) endothelial nitric oxide synthase (eNOS) has been shown to regulate intrinsic RBC rheologic properties, such as membrane deformability, suggesting that a functional eNOS could be important in RBC viability and function during storage. This study examines the correlation b... | These studies suggest that RBC eNOS does not modulate susceptibility to hemolysis in response to selected stress conditions or prolonged hypothermic storage. Other strategies to increase nitric oxide (NO) bioactivity after prolonged storage utilizing NOS-independent pathways such as the nitrate-nitrite-NO pathway may p... | no |
22,905,222 | Is cerebral oxygenation highly sensitive to blood pressure variability in sick preterm infants? | {
"contexts": [
"The significance of blood pressure variability (BPV) for cerebral oxygenation in extremely preterm infants has not been explored, though BPV may well be associated with end organ injury. We hypothesized that increased BPV in sick preterm infants, by exceeding the cerebral autoregulatory capacity,... | Fluctuation in cerebral oxygenation is closely associated with increased BPV in preterm infants undergoing intensive care. Moreover, in the critically sick preterm infant, blood pressure-dependent variations in cerebral oxygenation occur even with relatively lower BPV, suggesting they have severely impaired autoregulat... | yes |
22,879,632 | Is pancreatic volume reduced in adult patients with recently diagnosed type 1 diabetes? | {
"contexts": [
"Pancreatic atrophy is common in longstanding type 1 diabetes, but there are limited data concerning pancreas size at diagnosis.",
"Our objective was to determine whether pancreatic size was reduced in patients with recently diagnosed type 1 diabetes and assess whether pancreatic volume was re... | Pancreatic volume is reduced by 26% in patients with type 1 diabetes within months of diagnosis, suggesting that atrophy begins years before the onset of clinical disease. Pancreatic atrophy within individuals is therefore a potential clinical marker of disease progression. | yes |
22,879,630 | Does atorvastatin reduce malondialdehyde concentrations in patients with polycystic ovary syndrome? | {
"contexts": [
"It has been shown that there is an increase in oxidative stress in polycystic ovary syndrome (PCOS). Statins are considered to have a pleiotropic effect other than their lipid-lowering effect. These effects may be mediated in part by reducing oxidative stress.",
"This randomized, double-blind... | Twelve weeks of atorvastatin led to a significant reduction in oxidative stress as determined by MDA concentrations among patients with polycystic ovary syndrome that was independently predicted by changes in testosterone, 25OHD, and high-sensitivity C-reactive protein. | yes |
22,895,812 | Do 18F-FDG PET/CT metabolic tumor volume and total lesion glycolysis predict outcome in oropharyngeal squamous cell carcinoma? | {
"contexts": [
"Treatment of oropharyngeal squamous cell carcinoma with chemoradiotherapy can now accomplish excellent locoregional disease control, but patient overall survival (OS) remains limited by development of distant metastases (DM). We investigated the prognostic value of staging (18)F-FDG PET/CT, beyon... | Parameters capturing the volume of (18)F-FDG-positive disease (MTV or TLG) provide important prognostic information in oropharyngeal squamous cell carcinoma treated with chemoradiotherapy and should be considered for risk stratification in this disease. | yes |
22,893,765 | Does exercise training improve selected aspects of daytime functioning in adults with obstructive sleep apnea? | {
"contexts": [
"To explore the utility of exercise training for improving daytime functioning in adults with obstructive sleep apnea (OSA).",
"Forty-three sedentary and overweight/obese adults aged 18-55 years with at least moderate-severity untreated OSA (apnea-hypopnea index ≥ 15) were randomized to 12 wee... | These data provide preliminary evidence that exercise training may be helpful for improving aspects of daytime functioning of adults with OSA. Larger trials are needed to further verify the observed improvements. | yes |
22,909,379 | Does high preoperative blood levels of HE4 predict poor prognosis in patients with ovarian cancer? | {
"contexts": [
"The aim of this study was to assess the clinical value of preoperative blood levels of HE4 as a predictor of overall survival in patients with ovarian cancer and to validate previous data of HE4 and the ROMA algorithm including HE4 and CA125 in discriminating benign and malignant ovarian tumors."... | High concentration of plasma HE4 is an independent preoperative marker of poor prognosis in patients with ovarian cancer. The algorithm ROMA discriminates in postmenopausal women between malignant and benign tumors with an AUC of 0.94. | yes |
22,877,989 | Does over-expression of AQP7 contribute to improve insulin resistance in adipocytes? | {
"contexts": [
"Aquaglyceroporin 7 (AQP7) is required for efflux of glycerol from adipocytes. In this study, we aimed to analyze expression profiles of AQP7 in the different differentiation phases of adipocytes and to investigate the role of AQP7 in the insulin resistance of adipocytes.",
"3T3-L1 pre-adipocy... | AQP7 is down-regulated in adipocytes with insulin resistance. The over-expression of AQP7 contributes to improve insulin resistance in adipocytes, which is potentially correlated with the increased phosphorylation of PKB. | yes |
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