pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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22,884,061 | Do white blood cells contribute to patient-specific warfarin dose for Han Chinese? | {
"contexts": [
"Warfarin is the most commonly prescribed anticoagulant worldwide. Factors which influence warfarin's inter-individual requirements including age, weight, and genetic factors explained about 50% of dose variance, and unidentified factors still remain. The aim of this study was to explore whether w... | White blood cell count has a small but significant contribution to warfarin dose requirements in Han Chinese. | yes |
22,884,065 | Does pentoxifylline attenuate cigarette smoke-induced overexpression of CXCR3 and IP-10 in mice? | {
"contexts": [
"Cigarette smoke-induced emphysema is associated with overexpression of the chemokine receptor CXCR3 and its ligands. Previously, we have demonstrated that pentoxifylline (PTX) alleviated cigarette smoke-induced emphysema. The aim of this study was to determine if the overexpression of CXCR3 and i... | PTX attenuates cigarette smoke-induced overexpression of chemokine receptor CXCR3 and its ligand IP-10, which is relevant to its inhibitory effect on pulmonary emphysema. | yes |
22,886,030 | Is galectin-3 an independent marker for ventricular remodeling and mortality in patients with chronic heart failure? | {
"contexts": [
"Galectin-3 (Gal-3) is a recently discovered marker for myocardial fibrosis and elevated levels are associated with an impaired outcome after short-term follow-up in heart failure (HF) patients. However, whether Gal-3 is related to cardiac remodeling and outcome after long-term follow-up is unknow... | Gal-3 is associated with left ventricular remodeling determined by serial echocardiography and predicts long-term mortality in patients with severe chronic HF. | yes |
22,902,710 | Does body mass index affect knee joint mechanics during gait differently with and without moderate knee osteoarthritis? | {
"contexts": [
"Obesity is a highly cited risk factor for knee osteoarthritis (OA), but its role in knee OA pathogenesis and progression is not as clear. Excess weight may contribute to an increased mechanical burden and altered dynamic movement and loading patterns at the knee. The objective of this study was t... | Our results suggest that increased BMI is associated with different changes in biomechanical patterns of the knee joint during gait depending on the presence of moderate knee OA. | yes |
22,882,842 | Do mitogen-activated protein kinase signal pathways play an important role in right ventricular hypertrophy of tetralogy of Fallot? | {
"contexts": [
"Tetralogy of Fallot (TOF) is the most common malformation of children with an incidence of approximately 10% of congenital heart disease patients. There can be a wide spectrum to the severity of the anatomic defects, which include ventricular septal defect, aortic override, right ventricular outf... | The upregulation of genes in the MAPK signal pathway may be the key events that contribute to right ventricular hypertrophy and stunted angiogenesis in patients with TOF. | yes |
22,886,281 | Is masked hypertension prevalent in children with sickle cell disease : a Midwest Pediatric Nephrology Consortium study? | {
"contexts": [
"The prevalence of hypertension and abnormal blood pressure (BP) patterns on 24-h ambulatory BP monitoring (ABPM) remains unknown in children with sickle cell disease (SCD).",
"Thirty-eight asymptomatic children with sickle cell disease (SCD) (12 HbSS receiving routine care, 13 HbSC, and 13 Hb... | Abnormalities in ABP measurements and patterns in children with SCD are prevalent and require more attention from heath care providers. ABPM is a valuable tool in identifying masked hypertension and abnormalities in circadian BP. | yes |
22,901,178 | Is triple negative status a poor prognostic indicator in Chinese women with breast cancer : a ten year review? | {
"contexts": [
"Ethnic variation in tumor characteristics and clinical presentation of breast cancer is increasingly being emphasized. We studied the tumor characteristics and factors which may influence the presentation and prognosis of triple negative breast cancers (TNC) in a cohort of Chinese women.",
"A... | Chinese women with triple negative breast cancer do not have less aggressive biological behavior compared to the West and presentation at a later stage results in worse prognosis compared with those with non triple negative breast cancer. | yes |
22,881,836 | Is genetic variation in dopaminergic activity associated with the risk for psychiatric side effects of levetiracetam? | {
"contexts": [
"Levetiracetam (LEV) is a highly effective antiepileptic agent. A clinically relevant psychiatric complication of LEV treatment, however, is the provocation of irritability and aggression. Recent behavioral research indicates that personality traits may predispose to these side effects. To assess ... | Confirming the suggestion from behavioral observations that patients might be predisposed to develop irritation and aggression under treatment with LEV, the findings provide first evidence of an association of genetic variation in dopaminergic activity and the risk for psychiatric complications of LEV treatment. Replic... | yes |
22,898,621 | Does hydrogen sulfide attenuate spatial memory impairment and hippocampal neuroinflammation in β-amyloid rat model of Alzheimer 's disease? | {
"contexts": [
"Endogenously produced hydrogen sulfide (H(2)S) may have multiple functions in brain. An increasing number of studies have demonstrated its anti-inflammatory effects. In the present study, we investigated the effect of sodium hydrosulfide (NaHS, a H(2)S donor) on cognitive impairment and neuroinfl... | These results indicate that NaHS could significantly ameliorate Aβ(1-40)-induced spatial learning and memory impairment, apoptosis, and neuroinflammation at least in part via the inhibition of p38 MAPK and p65 NF-κB activity, suggesting that administration of NaHS could provide a therapeutic approach for AD. | yes |
22,909,378 | Are broadly reactive antibodies specific for Plasmodium falciparum MSP-1 ( 19 ) associated with the protection of naturally exposed children against infection? | {
"contexts": [
"The 19 kDa C-terminal region of Plasmodium falciparum Merozoite Surface Protein-1 is a known target of naturally acquired humoral immunity and a malaria vaccine candidate. MSP-119 has four predominant haplotypes resulting in amino acid changes labelled EKNG, QKNG, QTSR and ETSR. IgG antibodies di... | Variant transcending IgG antibodies to MSP-119 are associated with protection from infection in children, but not adults. These data suggest that inclusion of more than one MSP-119 variant may not be required in a malaria blood stage vaccine. | yes |
22,883,964 | Does reclassification of tumour origin in resected periampullary adenocarcinomas reveal underestimation of distal bile duct cancer? | {
"contexts": [
"Primary adenocarcinomas removed by pancreatoduodenectomy originate from the duodenum (DC), ampulla (AC), distal bile duct (DBC), or pancreas (PC). Pathobiology, staging, survival, and adjuvant chemotherapy vary among these cancers. The proximity of the structures of possible origin renders it dif... | Specialist slide review resulted in reassignment of tumour origin in 27% of periampullary adenocarcinomas. Distal bile duct cancer was found to be most frequently misdiagnosed (53%). Correct diagnosis of tumour origin is crucial for data quality, appropriate adjuvant therapy, and patient inclusion in clinical trials. | yes |
22,892,911 | Is renal macrophage infiltration associated with a poor outcome in IgA nephropathy? | {
"contexts": [
"The objectives of our study were as follows: 1) to analyze the prognostic value of macrophage infiltration in primary IgA nephropathy (IgAN) and 2) to study the relationship between macrophages and other factors associated with the development of renal fibrosis, including mast cells, TGF-β1, α-SM... | An increased number of macrophages in the tubulointerstitial area may serve as a predictive factor for poor prognosis in patients with IgAN, and these cells were also associated with the expression of pro-fibrotic factors. | yes |
22,903,258 | Does overexpression of microRNA-223 in rheumatoid arthritis synovium control osteoclast differentiation? | {
"contexts": [
"MicroRNAs, a class of noncoding RNAs, play roles in human diseases. MicroRNA-223 (miR-223) is reported to play critical roles in osteoclastogenesis. The purpose of this study was to analyze the expression pattern of miR-223 in rheumatoid arthritis (RA) synovium and examine the suppression of oste... | MiR-223 is intensely expressed in RA synovium, and overexpression of miR-223 suppresses osteoclastogenesis in vitro. This study demonstrates the possibility of gene therapy with miR-223 to treat bone destruction in RA patients. | yes |
22,894,820 | Does dexamphetamine selectively increase 40 Hz auditory steady state response power to target and nontarget stimuli in healthy humans? | {
"contexts": [
"An emerging endophenotype of schizophrenia is the reduction of both power and phase locking of the 40 Hz auditory steady state response (ASSR), and there have been a number of reports linking increased γ activity with positive psychotic symptoms. Schizophrenia and, more specifically, positive psy... | Dexamphetamine releases both noradrenaline and DA with equal potency. Further research with selective dopaminergic and noradrenergic agents will better characterize the effects of monoamines on γ activity. | yes |
22,894,825 | Is whole grain consumption inversely associated with BMI Z-score in rural school-aged children? | {
"contexts": [
"To examine the relationship between intake of whole grains and BMI Z-score in rural children.",
"General linear models and logistic regression were used to examine the cross-sectional associations between whole grain intake and BMI Z-score, prevalence and odds ratios of overweight and obesity... | Increasing the intake of whole grains as part of an overall healthy lifestyle may be beneficial for children to achieve and maintain a healthy weight. | yes |
22,899,775 | Does parental electrocardiographic screening identify a high degree of inheritance for congenital and childhood nonimmune isolated atrioventricular block? | {
"contexts": [
"The origin of congenital or childhood nonimmune isolated atrioventricular (AV) block remains unknown. We hypothesized that this conduction abnormality in the young may be a heritable disease.",
"A multicenter retrospective study (13 French referral centers, from 1980-2009) included 141 childr... | ECG screening in parents of children affected by idiopathic AV block revealed a high prevalence of conduction abnormalities. These results support the hypothesis of an inheritable trait in congenital and childhood nonimmune isolated AV block. | yes |
22,899,776 | Do genome-wide DNA methylation analyses in the brain reveal four differentially methylated regions between humans and non-human primates? | {
"contexts": [
"The highly improved cognitive function is the most significant change in human evolutionary history. Recently, several large-scale studies reported the evolutionary roles of DNA methylation; however, the role of DNA methylation on brain evolution is largely unknown.",
"To test if DNA methylat... | Our study provides a new angle of studying human brain evolution and understanding the evolutionary role of DNA methylation in the central nervous system. The results suggest that the patterns of DNA methylation in the brain are in general similar between humans and non-human primates, and only a few DMRs were identifi... | yes |
22,886,594 | Is heat shock protein 27 expression inversely correlated with atrophic gastritis and intraepithelial neoplasia? | {
"contexts": [
"Intestinal-type gastric carcinomas progress through several sequential steps, including atrophic gastritis, intestinal metaplasia, dysplasia, and cancer.",
"We investigated heat shock protein 27 (HSP27) expression in gastric neoplasia and background gastric mucosa to assess its involvement in... | HSP27 expression in gastric mucosae is inversely correlated with intraepithelial neoplasia, a probable precursor to gastric cancer, and HSP27 expression in cancer is positively correlated with poor differentiation. | yes |
22,885,022 | Is gene expression of human beta defensins-1 and -2 significantly reduced in non-inflamed keratinized oral tissue of smokers? | {
"contexts": [
"The impact of smoking on the local innate immune response in the oral cavity, and, commonly, on oral health is actively discussed in the scientific literature. The aim of the present study was to evaluate possible effects of smoking on gene expression of human beta-defensin-1 and -2 in human ging... | The results presented here suggest that expression of human beta-defensins hBD-1 and -2, and, thus, the basal levels of innate immune defense reactions in the oral cavity are reduced by smoking. | yes |
22,902,831 | Are changes in circulating concentrations of soluble fms-like tyrosine kinase-1 and placental growth factor measured by automated electrochemiluminescence immunoassays methods predictors of preeclampsia? | {
"contexts": [
"Preeclampsia is characterized by an imbalance in angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF). We herein assessed whether these factors measured by a newly developed automated electrochemiluminescence immunoassay are associated with ris... | Changes in circulating concentrations of PlGF, sFlt-1, and in the sFlt-1/PlGF ratio precede the onset of preeclampsia. The risk profile of circulating angiogenic factors for developing preeclampsia distinctly evolves depending on whether this condition is manifested at preterm or term. | yes |
22,879,828 | Does seroprevalence of hepatitis e virus vary considerably among chinese provinces? | {
"contexts": [
"Hepatitis E is a common infection in China, but few studies have been carried out to compare regional and ethnic factors in its prevalence.",
"To characterize the seroprevalence of anti-HEV IgM and IgG in the general population of 11 Chinese provinces and in the people from different ethnic m... | HEV prevalence varies considerably among Chinese provinces. Thus, prevention and control programs including vaccination could be specifically targeted to people living in regions with relatively higher prevalences. | yes |
22,882,550 | Do attitudes of general dental practitioners towards implant dentistry in an environment with widespread provision of implant therapy? | {
"contexts": [
"To determine attitudes of general dental practitioners in a community where provision dental implants is a well-known treatment modality; and to identify variations in the attitudes with respect to dentists' factors, training factors and implant provision factors.",
"A questionnaire survey to... | In a community where provision of dental implants is widespread among its General Dental Practitioners (GDPs), their attitudes are not wholly in line with evidence-based knowledge. Variations in their attitudes existed with respect to dentist factors, training and experience issues. | yes |
22,901,243 | Does plasma YKL-40 predict 10-year cardiovascular and all-cause mortality in individuals with type 2 diabetes? | {
"contexts": [
"Elevated YKL-40 concentrations have been observed in both coronary heart disease (CHD) and diabetes. Thus, YKL-40 may play a role in pathogenesis of CHD in patients with diabetes. We evaluated whether plasma YKL-40 concentration can predict all-cause and cardiovascular mortality in individuals wi... | Plasma YKL-40 concentration is an independent predictor of 10-year all-cause and cardiovascular mortality in subjects with type 2 diabetes. Further investigations on the role of YKL-40 in the pathogenesis of CVD are required to elucidate the underlying mechanisms. | yes |
22,880,115 | Does cXC chemokine receptor 7 ( CXCR7 ) regulate CXCR4 protein expression and capillary tuft development in mouse kidney? | {
"contexts": [
"The CXCL12/CXCR4 axis is involved in kidney development by regulating formation of the glomerular tuft. Recently, a second CXCL12 receptor was identified and designated CXCR7. Although it is established that CXCR7 regulates heart and brain development in conjunction with CXCL12 and CXCR4, little ... | We established that there is a similar glomerular pathology in CXCR7 and CXCR4 null embryos. Based on the phenotype and the anatomical organization of the CXCL12/CXCR4/CXCR7 system in the forming glomerulus, we propose that CXCR7 fine-tunes CXCL12/CXCR4 mediated signalling between podocytes and glomerular capillaries. | yes |
22,910,157 | Does participation of surgical residents adversely affect the outcome of inguinal hernia repair in an integrated teaching program? | {
"contexts": [
"The Lichtenstein inguinal hernia repair is commonly performed and suitable for teaching basic surgical skills. The objective of this study is to evaluate the feasibility of this procedure for surgical training, particularly in regard to patient outcomes.",
"Retrospective case review after int... | The Lichtenstein inguinal hernia repair can be safely performed by residents and junior faculty with the appropriate supervision of senior faculty without any disadvantage to patients. This integrated teaching program for Lichtenstein inguinal hernia repair is effective and feasible for training residents and junior fa... | no |
22,898,150 | Is metadherin a novel prognostic marker for bladder cancer progression and overall patient survival? | {
"contexts": [
"Metadherin (MTDH) is a potential oncogene in tumor development and is highly expressed in various types of human cancers. However, there has been no report on the role of MTDH in bladder cancer. Our aim was to investigate the expression pattern of MTDH in bladder tissue at different clinic pathol... | Our results suggest that MTDH protein may be a valuable marker of bladder cancer progression. MTDH expression is associated with poor overall survival in patients with bladder cancer. | yes |
22,879,784 | Is higher Dietary Protein Intake Associated with Lower Body Fat in the Newfoundland Population? | {
"contexts": [
"Increased protein proportions in the diet combined with energy restriction has been shown to enhance weight loss during dietary intervention. It is not known if the beneficial effect of dietary protein exists in the general population under normal living conditions without a negative energy balan... | This study provides strong evidence that higher protein intake, even in the absence of energy restriction, is associated with a more favorable body composition in the general population. | yes |
22,909,162 | Do racial disparities in allergic outcomes in African Americans emerge as early as age 2 years? | {
"contexts": [
"Racial disparities in allergic disease outcomes have been reported with African Americans suffering disproportionately compared to White individuals.",
"To examine whether or not racial disparities are present as early as age 2 years in a racially diverse birth cohort in the Detroit metropoli... | With disparities emerging as early as age 2 years, investigations into sources of the disparities should include the prenatal period and early life. | yes |
22,885,227 | Does primary closure using Redon drain vs vacuum-assisted closure in post-sternotomy mediastinitis? | {
"contexts": [
"Vacuum-assisted closure (VAC) is a commonly used therapy for the treatment of post-sternotomy mediastinitis. Primary closure of the sternum with high vacuum suction using Redon drains is an alternative that may reduce hospital stay. The aim of this study was to describe for the first time, the re... | Primary closure using high vacuum suction drains is a safe and feasible treatment modality for post-sternotomy mediastinitis. It reduces hospital stay when compared with VAC therapy, without compromising mortality. | yes |
22,878,870 | Does cTA spot sign predict hematoma expansion in patients with delayed presentation after intracerebral hemorrhage? | {
"contexts": [
"Hematoma expansion after acute intracerebral hemorrhage occurs most frequently in patients presenting within 3 h of symptom onset. However, the majority of patients present outside this window or with an unknown onset time. We investigated the prevalence of hematoma expansion in these patients an... | A substantial number of patients destined to suffer from hematoma expansion present either late or with an unknown symptom onset time. The CTA spot sign accurately identifies patients destined to expand regardless of time from symptom onset, and may therefore open a path to offer clinical trials and novel therapies to ... | yes |
22,906,975 | Does depletion of SUMO ligase hMMS21 impair G1 to S transition in MCF-7 breast cancer cells? | {
"contexts": [
"hMMS21 is a human SUMO ligase required for DNA damage repair and mitotic progression in HeLa cervical cancer cells. Owing to the diversity of cancer, we further investigated the effect of hMMS21-depletion on MCF-7 breast cancer cells.",
"hMMS21-depletion was achieved by RNA interference. Cell... | This study demonstrates that hMMS21 is required for G1-S transition in breast cancer cells and implies that manipulation of hMMS21-mediated sumoylation may alter the growth rates of breast cancer cells. | yes |
22,905,102 | Do untrained chimpanzees ( Pan troglodytes schweinfurthii ) fail to imitate novel actions? | {
"contexts": [
"Social learning research in apes has focused on social learning in the technical (problem solving) domain - an approach that confounds action and physical information. Successful subjects in such studies may have been able to perform target actions not as a result of imitation learning but becaus... | Chimpanzees do not seem to copy novel actions, and only some ever copy familiar ones. Due to our having tested only non-enculturated and untrained chimpanzees, the performance of our test subjects speak more than most other studies of the general (dis-)ability of chimpanzees to copy actions, and especially novel action... | yes |
22,905,106 | Do eye movements reveal effects of visual content on eye guidance and lexical access during reading? | {
"contexts": [
"Normal reading requires eye guidance and activation of lexical representations so that words in text can be identified accurately. However, little is known about how the visual content of text supports eye guidance and lexical activation, and thereby enables normal reading to take place.",
"T... | These findings suggest that while the orchestration of multiple scales of visual content is required for normal eye-guidance during reading, a broad range of visual content can activate processes of word identification independently. Implications for understanding the role of visual content in reading are discussed. | yes |
22,903,407 | Is food insecurity associated with greater acute care utilization among HIV-infected homeless and marginally housed individuals in San Francisco? | {
"contexts": [
"Food insecurity, or the uncertain availability of nutritionally adequate, safe foods, has been associated with poor HIV outcomes. There are few data on the extent to which food insecurity impacts patterns of health-care utilization among HIV-infected individuals.",
"We examined whether food i... | Food insecurity is associated with increased health services utilization among homeless and marginally housed HIV-infected individuals in San Francisco. Increased ED visits and hospitalizations are not related to fewer ambulatory care visits among food-insecure individuals. Addressing food insecurity should be a critic... | yes |
22,906,152 | Does intravitreal injection of soluble erythropoietin receptor exacerbate photoreceptor cell apoptosis in a rat model of retinal detachment? | {
"contexts": [
"To evaluate the effects of intravitreal injection of soluble erythropoietin (EPO) receptor (sEPOR) on photoreceptor cell apoptosis in an animal model of retinal detachment (RD).",
"Various dosages of sEPOR (2, 20, or 200 ng) were injected into the vitreous cavities of normal rats. Three days ... | Intravitreal injection of sEPOR exacerbates photoreceptor cell apoptosis in RD models via activation of caspase-3. | yes |
22,878,469 | Does hSC-specific inhibition of Rho-kinase reduce portal pressure in cirrhotic rats without major systemic effects? | {
"contexts": [
"Rho-kinase activation mediates cell contraction and increases intrahepatic resistance and consequently portal pressure in liver cirrhosis. Systemic Rho-kinase inhibition decreases portal pressure in cirrhosis, but also arterial pressure. Thus, liver-specific Rho-kinase inhibition is needed. The d... | Activated hepatic stellate cells are crucially involved in portal hypertension in cirrhosis. Targeting of Rho-kinase in hepatic stellate cells not only decreased fibrosis, as previously shown, but also lowers portal pressure acutely without major systemic effects as demonstrated in this study. | yes |
22,904,173 | Does gH replacement improve quality of life and metabolic parameters in cured acromegalic patients with growth hormone deficiency? | {
"contexts": [
"Effects of GH replacement in patients with GH deficiency (GHD) after a cure for acromegaly so far have been poorly studied, although its prevalence among acromegalic patients may reach the 60%. The aim of the study was to evaluate whether metabolic parameters and quality of life are improved by G... | In GHD acromegalic patients, GH therapy improved body composition, lipid profile, and quality of life as in patients with GHD due to nonfunctioning pituitary adenoma, without negative effects on glucose metabolism. GH replacement therapy should be considered in these patients, as in patients with GHD from other causes. | yes |
22,904,175 | Are bone turnover and bone mineral density independently related to selenium status in healthy euthyroid postmenopausal women? | {
"contexts": [
"Selenium status may have direct effects on bone and indirect effects through changes in thyroid hormone sensitivity.",
"We hypothesized that variation in selenium status in healthy euthyroid postmenopausal women is associated with differences in bone turnover, bone mineral density (BMD) and f... | Selenium status is inversely related to bone turnover and positively correlated with BMD in healthy euthyroid postmenopausal women independent of thyroid status. | yes |
22,904,174 | Is inflammation in response to glucose ingestion independent of excess abdominal adiposity in normal-weight women with polycystic ovary syndrome? | {
"contexts": [
"Inflammation and excess abdominal adiposity (AA) are often present in normal-weight women with polycystic ovary syndrome (PCOS).",
"We determined the effects of hyperglycemia on nuclear factor-κB (NFκB) activation in mononuclear cells (MNC) of normal-weight women with PCOS with and without ex... | In normal-weight women with PCOS, the inflammatory response to glucose ingestion is independent of excess AA. Circulating MNC and excess AA are separate and unique sources of inflammation in this population. | yes |
22,878,464 | Is elevated D-dimer independently associated with endothelial dysfunction : a cross-sectional study in HIV-infected adults on antiretroviral therapy? | {
"contexts": [
"D-Dimer elevations have been associated with a striking increase in mortality in HIV-infected patients. However, D-Dimer has not been directly linked to endothelial dysfunction in HIV.",
"In this cross-sectional study, we used flow-mediated dilation (FMD) of the brachial artery to measure end... | We show for the first time an independent association between D-Dimer and endothelial dysfunction in virologically suppressed, HIV-infected adults on stable antiretroviral therapy, potentially explaining the link between D-Dimer and mortality in HIV. | yes |
22,880,065 | Does the colitis-associated transcriptional profile of commensal Bacteroides thetaiotaomicron enhance adaptive immune responses to a bacterial antigen? | {
"contexts": [
"Inflammatory bowel diseases (IBD) may be caused in part by aberrant immune responses to commensal intestinal microbes including the well-characterized anaerobic gut commensal Bacteroides thetaiotaomicron (B. theta). Healthy, germ-free HLA-B27 transgenic (Tg) rats develop chronic colitis when colo... | B. theta induces colitis in HLA-B27 Tg rats, which is associated with regulation of bacterial genes in metabolic and nutrient binding pathways that may affect host immune responses. These studies of the host-microbial dialogue may lead to the identification of novel microbial targets for IBD therapies. | yes |
22,887,595 | Does poloxamer synperonic F108 improve cellular transduction with lentiviral vectors? | {
"contexts": [
"Although lentiviral transduction methods are widely used, their broader application is dependent upon the optimization of lentiviral transduction efficiency for a broad range of cell types. In the present study, we focus on the evaluation of two chemical classes with respect to their ability to i... | The results obtained in the present study indicate that a contribution to efficiency is made by each adjuvant, with polybrene acting as a charge protector and poloxamer synperonic F108 as a membrane modulator. Therefore, poloxamer synperonic F108, either alone or in combination, can lead to the optimization of large-sc... | yes |
22,883,744 | Is apolipoprotein C-I an APOE genotype-dependent suppressor of glial activation? | {
"contexts": [
"Inheritance of the human ε4 allele of the apolipoprotein (apo) E gene (APOE) significantly increases the risk of developing Alzheimer's disease (AD), in addition to adversely influencing clinical outcomes of other neurologic diseases. While apoE isoforms differentially interact with amyloid β (Aβ... | ApoC-I is immunosuppressive. Our results illuminate a novel potential mechanism for APOE genotype risk for AD; one in which patients with an ε4 allele have decreased expression of apoC-I resulting in increased innate immune activity. | yes |
22,894,640 | Are omega-3 fatty acids protective against paclitaxel-induced peripheral neuropathy : a randomized double-blind placebo controlled trial? | {
"contexts": [
"Axonal sensory peripheral neuropathy is the major dose-limiting side effect of paclitaxel.Omega-3 fatty acids have beneficial effects on neurological disorders from their effects on neurons cells and inhibition of the formation of proinflammatory cytokines involved in peripheral neuropathy.",
... | Omega-3 fatty acids may be an efficient neuroprotective agent for prophylaxis against PIPN. Patients with breast cancer have a longer disease free survival rate with the aid of therapeutical agents. Finding a way to solve the disabling effects of PIPN would significantly improve the patients' quality of life. | yes |
22,890,011 | Does genome-wide association study indicate variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate? | {
"contexts": [
"A shift towards overall larger very low-density lipoprotein (VLDL), and smaller low-density lipoprotein and high-density lipoprotein (HDL) diameters occurs in insulin resistance (IR), which reflects shifts in the distribution of the subfraction concentrations. Fenofibrate, indicated for hypertrig... | We report novel associations between lipoprotein diameter responses to fenofibrate and the AHCYL2 and CD36 genes. Previous associations of these genes with IR emphasize the role of IR in mediating lipoprotein response to fenofibrate. | yes |
22,890,014 | Does vitamin E alter inflammatory gene expression in alcoholic chronic pancreatitis? | {
"contexts": [
"To evaluate the effect of vitamin E supplementation on pancreatic gene expression of inflammatory markers in rats with alcoholic chronic pancreatitis.",
"Wistar rats were divided into 3 groups: control (1), alcoholic chronic pancreatitis without (2) and with (3) vitamin E supplementation. Pan... | Vitamin E supplementation had anti-inflammatory and beneficial effects on the pancreatic gene expression of some inflammatory biomarkers in rats with alcoholic chronic pancreatitis, confirming its participation in the inflammatory response mechanisms in the pancreas. | yes |
22,891,764 | Do parents of children with congenital heart disease prefer more information than cardiologists provide? | {
"contexts": [
"To determine whether pediatric cardiologists and parents of older children with congenital heart disease (CHD) share similar expectations regarding the education and counseling that should be provided to parents of children with CHD in both the prenatal and neonatal period.",
"Consenting pare... | Parents of older children with CHD would prefer to receive more counseling and education in the prenatal and newborn period than cardiologists perceive is wanted. | yes |
22,878,408 | Are rates of coronary intervention due to de novo significant atherosclerosis and cardiac death very low in Korean patients with vasospastic angina : 36-month follow-up results of the Vasospastic Angina in the Catholic Medical Center ( VA-CMC ) registry? | {
"contexts": [
"The rate of percutaneous coronary intervention (PCI) due to the development of significant atherosclerosis and the cardiac mortality rate in Korean patients with vasospastic angina (VSA) was estimated.",
"A total of 831 patients with VSA from 8 centers were registered in the Vasospastic Angin... | Korean patients with VSA demonstrated low rates of development of significant atherosclerosis leading to PCI and cardiac mortality. However, cessation of medication, smoking, and high baseline hsCRP were the independent risk factors for unfavorable outcomes. | yes |
22,878,259 | Does epidural direct current stimulation over the left medial prefrontal cortex facilitate spatial working memory performance in rats? | {
"contexts": [
"Extensive evidence supports the notion that modulation of PFC excitability using low-intensity electrical stimulation is a promising modality for treating neuropsychiatric diseases and improving cognitive function.",
"This study examined the effects of epidural direct current stimulation (eDC... | Our results suggest that epidural direct current stimulation over the mPFC facilitates spatial working memory in rats, an effect that persisted over the long term. | yes |
22,889,236 | Does mild metabolic acidosis impair the β-adrenergic response in isolated human failing myocardium? | {
"contexts": [
"Pronounced extracellular acidosis reduces both cardiac contractility and the β-adrenergic response. In the past, this was shown in some studies using animal models. However, few data exist regarding how the human end-stage failing myocardium, in which compensatory mechanisms are exhausted, reacts... | Our data show that mild metabolic acidosis reduces cardiac contractility and significantly impairs the β-adrenergic force response in human failing myocardium. Thus, our results could contribute to the still-controversial discussion about the therapy regimen of acidosis in patients with critical heart failure. | yes |
22,889,230 | Do virus-producing cells determine the host protein profiles of HIV-1 virion cores? | {
"contexts": [
"Upon HIV entry into target cells, viral cores are released and rearranged into reverse transcription complexes (RTCs), which support reverse transcription and also protect and transport viral cDNA to the site of integration. RTCs are composed of viral and cellular proteins that originate from bot... | Profiles of host proteins packaged in the cores of HIV-1 virions depend on the type of virus producing cell. The pool of proteins present in the cores of all virions is likely to contain factors important for viral functions. Incorporation ratio of certain RNA- and DNA-binding proteins suggests their more efficient, no... | yes |
22,909,235 | Do gene-gene interactions in IL23/Th17 pathway contribute to psoriasis susceptibility in Chinese Han population? | {
"contexts": [
"Psoriasis is a common chronic inflammatory skin disease. IL23/Th17 is a newly confirmed pathway in psoriasis.",
"To investigate the gene-gene interactions in IL23/Th17 pathway underlying psoriasis.",
"A total of 299 single-nucleotide polymorphisms from 11 genes in IL23/Th17 pathway were g... | Our results might be helpful for explaining the missing heritability of the psoriasis due to epistasis and provide a deep insight into the important role of the IL23/Th17 pathway in the pathogenesis of psoriasis. | yes |
22,885,873 | Is acquisition and reconditioning of ethanol-induced conditioned place preference in mice blocked by the H₂O₂ scavenger alpha lipoic acid? | {
"contexts": [
"Hydrogen peroxide (H2O2) is the co-substrate used by catalase to metabolize ethanol to acetaldehyde in the brain. This centrally formed acetaldehyde has been involved in several ethanol-related behaviors.",
"The present research evaluated the effect of the H2O2 scavenger, alpha lipoic acid (L... | These data suggest that a decline in H2O2 availability by LA might impede the formation of brain ethanol-derived acetaldehyde by catalase, which results in an impairment of the rewarding properties of ethanol. | yes |
22,892,392 | Does bCAR4 induce antioestrogen resistance but sensitises breast cancer to lapatinib? | {
"contexts": [
"High BCAR4 and ERBB2 mRNA levels in primary breast cancer associate with tamoxifen resistance and poor patient outcome. We determined whether BCAR4 expression sensitises breast cancer cells to lapatinib, and identifies a subgroup of patients who possibly may benefit from ERBB2-targeted therapies ... | This study shows that BCAR4 expression identifies a subgroup of ER-positive breast cancer patients without overexpression of ERBB2 who have a poor outcome and might benefit from combined ERBB2-targeted and antioestrogen therapy. | yes |
22,892,398 | Do asymmetric dimethylarginine concentrations decrease in patients with HIV infection under antiretroviral therapy? | {
"contexts": [
"In HIV-infected patients, elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor and cardiovascular risk factor asymmetric dimethylarginine (ADMA) are documented, and levels correlate with markers of immune activation, such as neopterin.",
"In this study, the effect ... | Successful ART, defined by HIV RNA levels below the limit of detection, leads to decreasing levels of methylated arginines and immune activation markers. Thus, it is unlikely that disturbances of dimethylarginine metabolism account for the increased risk of cardiovascular events of HIV-infected patients under ART. | yes |
22,882,772 | Does pyrosequencing-based analysis reveal a novel capsular gene cluster in a KPC-producing Klebsiella pneumoniae clinical isolate identified in Brazil? | {
"contexts": [
"An important virulence factor of Klebsiella pneumoniae is the production of capsular polysaccharide (CPS), a thick mucus layer that allows for evasion of the host's defense and creates a barrier against antibacterial peptides. CPS production is driven mostly by the expression of genes located in ... | We report the first description of a cps cluster from a Brazilian clinical isolate of a KPC-producing K. pneumoniae. The gathered data including K-serotyping support that Kp13's K-antigen belongs to a novel capsular serotype. The CPS of Kp13 probably includes L-rhamnose and D-galacturonate in its structure, among other... | yes |
22,904,342 | Is host cytokine storm associated with disease severity of severe fever with thrombocytopenia syndrome? | {
"contexts": [
"Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease in China, caused by SFTS virus (SFTSV). Severe SFTS patients can quickly proceed to multiorgan dysfunction and death; however, underlying pathogenic mechanisms remain unclear.",
"Serum samples from 15 fatal and 44... | The study demonstrates that SFTSV infection induces a cytokine storm with abnormally expressed cytokine profiles, which are associated with the disease severity. | yes |
22,906,272 | Is the synergistic therapeutic effect of temozolomide and hyperbaric oxygen on glioma U251 cell lines accompanied by alterations in vascular endothelial growth factor and multidrug resistance-associated protein-1 levels? | {
"contexts": [
"Temozolomide (TMZ) is an oral alkylating agent widely used in the treatment of refractory glioma. Its efficacy is limited, however, by poor cancer cell penetration and drug resistance. The present study, therefore, aimed to investigate whether hyperbaric oxygen (HBO) may facilitate drug delivery... | TMZ and HBO synergistically induced the apoptosis of glioma cells, possibly through reduced vascularization and inhibition of drug resistance. The combination of TMZ and HBO may be a powerful treatment for malignant glioma. | yes |
22,882,209 | Is high serum vascular endothelial growth factor level an adverse prognostic factor for high-risk diffuse large B-cell lymphoma patients treated with dose-dense chemoimmunotherapy? | {
"contexts": [
"To determine whether serum vascular endothelial growth factor (s-VEGF) levels and VEGF gene expression in tumor tissue predict survival of diffuse large B-cell lymphoma (DLBCL) patients treated with chemoimmunotherapy.",
"VEGF levels were measured in serum samples from 102 patients <65 yrs wi... | Pretreatment s-VEGF level is a predictor of PFS after chemoimmunotherapy and may help to further stratify high-risk DLBCL patients into low- and high-risk groups. | yes |
22,878,146 | Does nHE1 inhibition improve tissue perfusion and resuscitation outcome after severe hemorrhage? | {
"contexts": [
"This study tested the hypothesis that blockade of the pH-regulatory protein, Na+/H+ exchanger (NHE1) during prolonged hemorrhagic shock can protect against whole-body ischemia-reperfusion injury, resulting in improved neurological outcomes.",
"We used a total of 24 male pigs in this study. We... | In this study, NHE1 inhibition with BIIB513 improved vital organ blood flow, prevented the development of metabolic acidosis during prolonged hypovolemia, and facilitated the hemodynamic response to fluid resuscitation, resulting in increased survival and normal neurological outcomes. | yes |
22,883,929 | Do hemicelluloses negatively affect lignocellulose crystallinity for high biomass digestibility under NaOH and H2SO4 pretreatments in Miscanthus? | {
"contexts": [
"Lignocellulose is the most abundant biomass on earth. However, biomass recalcitrance has become a major factor affecting biofuel production. Although cellulose crystallinity significantly influences biomass saccharification, little is known about the impact of three major wall polymers on cellulo... | Using six pairs of Miscanthus samples with different cell wall compositions, hemicelluloses were revealed to be the dominant factor that positively determined biomass digestibility after pretreatments with NaOH or H2SO4 by negatively affecting cellulose crystallinity. The results suggested potential approaches to the g... | yes |
22,909,128 | Does cross-sectional assessment of prevalence and correlate of blood-borne and sexually-transmitted infections among Afghan National Army recruits? | {
"contexts": [
"Few data are available in Afghanistan to shape national military force health practices, particularly with regard to sexually-transmitted infections (STIs). We measured prevalence and correlates of HIV, syphilis, herpes simplex 2 virus (HSV-2), and hepatitis C virus (HCV) among Afghan National Ar... | Though prevalence of HIV, HCV, syphilis, and HSV-2 was low, sexual risk behaviors and intoxicant use were present among a substantial minority, indicating need for prevention programming. Formative work is needed to determine a culturally appropriate approach for prevention programming to reduce STI risk among Afghan N... | yes |
22,886,117 | Does clinical aspects and frequency of scorpion sting in the Riyadh region of Saudi Arabia? | {
"contexts": [
"To study the clinical aspects and frequency of scorpion stings in Riyadh region of Saudi Arabia.",
"Clinical aspects and frequency of scorpion sting cases reporting to 2 referral hospitals in the Riyadh region of Saudi Arabia were analyzed during May 2006 to April 2008. Data on demographic st... | The high prevalence of scorpion stings largely with mild signs/symptoms and without any mortality suggests the predominance of weak venomous scorpion species in the Riyadh region. Therefore, the protocol of managing scorpion-sting patients with anti-venom irrespective of the intensity of manifestations warrants a detai... | yes |
22,878,280 | Does class A scavenger receptor deficiency exacerbate lung tumorigenesis by cultivating a procarcinogenic microenvironment in humans and mice? | {
"contexts": [
"Genetic alterations on 8p22 have been implicated in multiple cancers, including lung cancer. In this region, genetic variants of the class A scavenger receptor (SR-A) gene have been associated with prostate cancer risk and have been highlighted as a potential susceptibility gene of cancer.",
... | Evidence from the population study and mouse model strongly indicates that SR-A may function as a tumor modulator to inhibit lung cancer growth through affecting the tumor microenvironment. | yes |
22,906,872 | Does simultaneous placement of multiple central lines increase central line-associated bloodstream infection rates? | {
"contexts": [
"Surveillance for central line (CL)-associated bloodstream infections (CLABSIs) is generally advocated. However, the standard definition of this surveillance does not take into account the number of CLs in place and thus the possibility of increased infection risk with multiple CLs in place simult... | Our data show that the number of CLs in place had a strong influence on CLABSI rates. Thus, we advocate stratifying patients by the number of CLs in place to take this increased risk of infection into account during surveillance. | yes |
22,898,544 | Are neuroexcitatory effects of morphine-3-glucuronide dependent on Toll-like receptor 4 signaling? | {
"contexts": [
"Multiple adverse events are associated with the use of morphine for the treatment of chronic non-cancer pain, including opioid-induced hyperalgesia (OIH). Mechanisms of OIH are independent of opioid tolerance and may involve the morphine metabolite morphine-3-glucuronide (M3G). M3G exhibits limit... | These outcomes provide evidence that M3G may play a role in OIH via the TLR4/MD-2 heterodimer complex and biophysical properties of tetrodotoxin-sensitive and tetrodotoxin-resistant NaV currents. | yes |
22,901,009 | Do patients undergoing subacute rehabilitation have accurate expectations of their health-related quality of life at discharge? | {
"contexts": [
"Expectations held by patients and health professionals may affect treatment choices and participation (by both patients and health professionals) in therapeutic interventions in contemporary patient-centered healthcare environments. If patients in rehabilitation settings overestimate their discha... | Patients admitted for subacute in-hospital rehabilitation were able to anticipate their discharge health-related quality of life on the EQ-5D instrument with a moderate level of accuracy. This finding adds to the foundational empirical work supporting joint treatment decision making and patient-centered models of care ... | yes |
22,884,488 | Are serum levels of pigment epithelium-derived factor ( PEDF ) independently associated with procollagen III N-terminal peptide levels in patients with nonalcoholic fatty liver disease? | {
"contexts": [
"Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors with complex anti-oxidative, anti-fibrotic, and anti-inflammatory properties, thus being involved in cardiometabolic disorders. Nonalcoholic fatty liver disease (NAFLD) is a he... | The present study reveals that serum levels of PEDF are independently associated with P-III-P levels, suggesting that PEDF level is a novel biomarker of liver fibrosis in patients with NAFLD. | yes |
22,897,914 | Does next-generation sequencing of cervical DNA detect human papillomavirus types not detected by commercial kits? | {
"contexts": [
"Human papillomavirus (HPV) is the aetiological agent for cervical cancer and genital warts. Concurrent HPV and HIV infection in the South African population is high. HIV positive (+) women are often infected with multiple, rare and undetermined HPV types. Data on HPV incidence and genotype distri... | Our results indicate that there are HPV types, with substantial prevalence, in HIV positive women not being detected in molecular epidemiology studies using commercial kits. The significance of these types in relation to cervical disease remains to be investigated. | yes |
22,893,469 | Does a common variant in the precursor miR-146a sequence predispose to cholangiocarcinoma in a large European cohort? | {
"contexts": [
"Micro-RNAs (miRNAs) are small, non-coding RNA species considered to fine-tune basic cellular functions by modulating target gene translation and/or mRNA stability. A common G/C polymorphism (rs2910164) in the precursor (pre-) miR-146a gene engaged in NF-κB signaling and apoptosis pathways has bee... | Our data do not support a prominent contribution of the pre-miR-146a sequence variant in the genetic predisposition to CCA. However, current studies functionally characterizing rs2910164 have proposed that distinct repertoires of target genes are addressed by genotype-specific mature miR-146a species. Given the detecte... | no |
22,908,327 | Do low 25-hydroxyvitamin D serum levels correlate with the presence of extra-hepatic manifestations in chronic hepatitis C virus infection? | {
"contexts": [
"Chronic HCV infection is associated with extra-hepatic manifestations. Recent studies have suggested an immunomodulatory role for vitamin D during HCV infection. We investigated the association between serum vitamin D status and the presence of HCV extra-hepatic manifestations.",
"25(OH)D ser... | In chronic HCV infection, low 25(OH)D levels correlate with the presence of mixed cryoglobulinaemia and systemic vasculitis in chronic HCV infection. These findings suggest the potential multifaceted benefits of vitamin D supplementation in HCV-infected patients with extra-hepatic manifestations, but interventional stu... | yes |
22,889,597 | Does aging differentially affect human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise? | {
"contexts": [
"Amino acid transporters have been proposed as regulators of protein synthesis. The primary aim of this study was to determine whether amino acid transporter expression is increased in human muscle following resistance exercise (RE) coupled with essential amino acid (EAA) ingestion, and whether a ... | RE increases muscle amino acid transporter expression in young and older adults, however, post exercise EAA ingestion enhances amino acid transporter expression only in young indicating that aging may influence the function of specific amino acid transporters. | yes |
22,882,234 | Does loss of CD26 protease activity in recipient mice during hematopoietic stem cell transplantation result in improved transplant efficiency? | {
"contexts": [
"A firm understanding of the biology of hematopoietic stem and progenitor cell (HSC/HPC) trafficking is critical to improve transplant efficiency and immune reconstitution during hematopoietic stem cell transplantation (HSCT). Our earlier findings suggested that suppression of CD26 (dipeptidyl pep... | These results provide preclinical evidence of CD26, in the HSCT recipient, as a major regulator of HSC/HPC engraftment with minor effects on HSC/HPC homing and suggest the potential use of CD26 inhibitors in HSCT patients to improve transplant efficiency. | yes |
22,898,209 | Are high glycemic load diet , milk and ice cream consumption related to acne vulgaris in Malaysian young adults : a case control study? | {
"contexts": [
"The role of dietary factors in the pathophysiology of acne vulgaris is highly controversial. Hence, the aim of this study was to determine the association between dietary factors and acne vulgaris among Malaysian young adults.",
"A case-control study was conducted among 44 acne vulgaris patie... | Glycemic load diet and frequencies of milk and ice cream intake were positively associated with acne vulgaris. | yes |
22,882,874 | Does infection with street strain rabies virus induce modulation of the microRNA profile of the mouse brain? | {
"contexts": [
"Rabies virus (RABV) causes a fatal infection of the central nervous systems (CNS) of warm-blooded animals. Once the clinical symptoms develop, rabies is almost invariably fatal. The mechanism of RABV pathogenesis remains poorly understood. Recent studies have shown that microRNA (miRNA) plays an ... | RABV causes significant changes in the miRNA expression profiles of infected mouse brains. Predicted target genes of the differentially expression miRNAs are associated with host immune response, which may provide important information for investigation of RABV pathogenesis and therapeutic method. | yes |
22,884,451 | Does angiotensin II inhibit interleukin-6 mRNA expression of LPS-stimulated macrophages through down-regulating calcium signaling? | {
"contexts": [
"The renin-angiotensin system plays a key role in the regulation of blood pressure following hemorrhage and shock. Recent studies also suggest renin-angiotensin system regulates inflammatory mediator production although the amechanism is largely unknown. This purpose of the study was to examine th... | Our data show that calcium signaling is closely related to IL-6 mRNA expression. Angiotensin II inhibits IL-6 mRNA expression of LPS-stimulated MØ. The inhibitory effects of angiotensin II appear, at least in part, to be mediated through down regulating calcium dependent pathways. | yes |
22,898,488 | Does the I148M PNPLA3 polymorphism influence serum adiponectin in patients with fatty liver and healthy controls? | {
"contexts": [
"Reduced adiponectin is implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), and the I148M Patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism predisposes to NAFLD and liver damage progression in NASH and chronic hepatitis C (CHC) ... | The I148M PNPLA3 variant is associated with adiponectin levels in patients with NAFLD and in healthy subjects, but in the presence of adiponectin resistance not in CHC patients. The I148M PNPLA3 genotype may represent a genetic determinant of serum adiponectin levels. Modulation of serum adiponectin might be involved i... | yes |
22,879,962 | Are metabolic parameters and emotionality little affected in G-protein coupled receptor 12 ( Gpr12 ) mutant mice? | {
"contexts": [
"G-protein coupled receptors (GPR) bear the potential to serve as yet unidentified drug targets for psychiatric and metabolic disorders. GPR12 is of major interest given its putative role in metabolic function and its unique brain distribution, which suggests a role in emotionality and affect. We ... | Studying metabolic and emotionality parameters in Gpr12 mutant mice did not reveal a major phenotypic impact of the gene mutation. Compared to previous results showing a metabolic phenotype in Gpr12 mice with a mixed 129 and C57Bl6 background, we suggest that a more pure C57Bl/6 background due to further backcrossing m... | yes |
22,889,687 | Is failure to increase insulin secretory capacity during pregnancy-induced insulin resistance associated with ethnicity and gestational diabetes? | {
"contexts": [
"To assess changes in insulin resistance and β-cell function in a multiethnic cohort of women in Oslo, Norway, from early to 28 weeks' gestation and 3 months post partum and relate the findings to gestational diabetes mellitus (GDM).",
"Population-based cohort study of 695 healthy pregnant wom... | Pregnant women from East Asia and South Asia were more insulin resistant and showed poorer HOMA-β-cell function than Western Europeans. | yes |
22,905,179 | Does caloric restriction induce changes in insulin and body weight measurements that are inversely associated with subsequent weight regain? | {
"contexts": [
"Successful weight maintenance following weight loss is challenging for many people. Identifying predictors of longer-term success will help target clinical resources more effectively. To date, focus has been predominantly on the identification of predictors of weight loss. The goal of the current... | LCD-induced changes in BMI, fasting insulin, and HOMA-IR are inversely associated with weight regain in the 6-month period following weight loss. | yes |
22,890,622 | Is lower health literacy associated with poorer health status and outcomes in chronic obstructive pulmonary disease? | {
"contexts": [
"Limited health literacy is associated with poor outcomes in many chronic diseases, but little is known about health literacy in chronic obstructive pulmonary disease (COPD).",
"To examine the associations between health literacy and both outcomes and health status in COPD. PARTICIPANTS, DESIG... | Independent of socioeconomic status, poor health literacy is associated with greater COPD severity, greater COPD helplessness, worse respiratory-specific HRQoL, and higher odds of COPD-related emergency health-care utilization. These results underscore that COPD patients with poor health literacy may be at particular r... | yes |
22,896,024 | Are vertebral fractures in ankylosing spondylitis associated with lower bone mineral density in both central and peripheral skeleton? | {
"contexts": [
"To study the prevalence and risk factors for vertebral fractures (VF) in ankylosing spondylitis (AS) and the relation between VF, measures of disease activity, and bone mineral density (BMD) in different measurement sites.",
"Patients with AS (modified New York criteria) underwent examination... | VF in AS are common but are often not diagnosed. VF are associated with advanced age, longstanding disease, impaired back mobility, syndesmophyte formation, and lower BMD in both the central and peripheral skeleton. BMD in the femoral neck, total hip, and estimated vBMD showed the strongest association with VF. | yes |
22,905,833 | Does platelet recovery rate during plasma exchange predict early and late responses in patients with thrombotic thrombocytopenic purpura? | {
"contexts": [
"Therapeutic plasma exchange (TPE) is the first-line therapy for patients with thrombotic thrombocytopenic purpura (TTP). However, therapeutic response to TPE and late prognosis vary among different patients, and predictors of these outcomes may help customize treatments to individual patients.",
... | PRR3 with a cutoff of 5 × 10(9) /L per 24 hours provides a practical approach to risk stratify TTP patients receiving TPE early in their treatment and may guide the decision making both at initial encounters and during the long-term follow-up. | yes |
22,890,388 | Is transcriptional repression of RUNX2 associated with aggressive clinicopathological outcomes , whereas nuclear location of the protein is related to metastasis in prostate cancer? | {
"contexts": [
"Runt-related transcription factor 2 (RUNX2) is a transcription factor that is closely related to bone formation, and prostate cancer (CaP) is the most common cancer to metastasize to bone. The present study investigated the expression levels of RUNX2 in human prostate tissue, and the correlation ... | RUNX2 mRNA expression was negatively correlated with CaP aggressiveness. Moreover, the nuclear location of RUNX2 may be a prognostic marker of metastasis in CaP. | yes |
22,894,833 | Is monosodium glutamate associated with overweight in Vietnamese adults? | {
"contexts": [
"To determine the prevalence of and associated factors for overweight, especially to determine the relationship between the intake of monosodium glutamate (MSG) as a seasoning and overweight in Vietnam.",
"A cross-sectional survey was conducted of Vietnamese adults aged ≥20 years in 2008. Diet... | The study demonstrated that overweight was not associated with MSG intake in Vietnamese adults. Further longitudinal studies should be done in different populations to determine the relationship between MSG and overweight. | no |
22,888,272 | Are variants of the gentamicin and tobramycin resistance plasmid pRAY widely distributed in Acinetobacter? | {
"contexts": [
"To determine the cause of resistance to the aminoglycosides gentamicin and tobramycin in Acinetobacter isolates and the location of the resistance genes.",
"Australian Acinetobacter baumannii isolates were screened for resistance to aminoglycosides. PCR followed by restriction digestion of am... | The plasmid pRAY* and variants are widely distributed in Acinetobacter spp. and are the most common cause of resistance to gentamicin and tobramycin. Mobilization genes should assist in the dissemination of pRAY* and its variants. | yes |
22,893,672 | Does a novel Schlemm 's Canal scaffold increase outflow facility in a human anterior segment perfusion model? | {
"contexts": [
"An intracanalicular scaffold (Hydrus microstent) designed to reduce intraocular pressure as a glaucoma treatment was tested in human anterior segments to determine changes in outflow facility (C).",
"Human eyes with no history of ocular disease or surgeries were perfused within 49 hours of de... | The Hydrus Microstent provided an effective way to increase outflow facility in human eyes ex vivo. | yes |
22,889,061 | Does combination of renal biomarkers predict acute kidney injury in critically ill adults? | {
"contexts": [
"Most studies so far have focused on the performance of individual biomarkers to detect early acute kidney injury (AKI) in the adult intensive care unit (ICU) patients; however, they have not determined the predictive ability of their combinations. The aim of this study was to compare the predicti... | The biomarker combinations had better predictive characteristics compared with those of each biomarker alone. | yes |
22,883,210 | Does selective loss of noradrenaline exacerbate early cognitive dysfunction and synaptic deficits in APP/PS1 mice? | {
"contexts": [
"Degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in the brain, occurs early and is ubiquitous in Alzheimer's disease (AD). Experimental lesions to the LC exacerbate AD-like neuropathology and cognitive deficits in several transgenic mouse models of AD. Because the LC cont... | These results indicate that early LC degeneration and subsequent NA deficiency in AD may contribute to cognitive deficits via altered levels of calcium/calmodulin-dependent protein kinase II and N-methyl-D-aspartate receptors and suggest that NA supplementation could be beneficial in early AD. | yes |
22,883,212 | Does community influence on adolescents ' use of home-brewed alcohol in rural South Africa? | {
"contexts": [
"Alcohol represents a major public health challenge in South Africa, however little is known about the correlates of alcohol use among rural adolescents. This article examines community influences on adolescents' use of home-brewed alcohol in a rural region of South Africa.",
"A total of 1600 ... | Findings highlight community influences on alcohol use among rural adolescents in South Africa. Feeling affirmed and valued by the broader community appears to protect adolescents against early alcohol use. In contrast, perceptions of high levels of adult anti-social behavior and crime and violence in the community are... | yes |
22,901,274 | Is genetic variation in the TNF receptor-associated factor 6 gene associated with susceptibility to sepsis-induced acute lung injury? | {
"contexts": [
"Recent studies showed that overwhelming inflammatory response mediated by the toll-like receptor (TLR)-related pathway was important in the development of acute lung injury (ALI). The aim of this study was to determine whether common genetic variation in four genes of the TLR signaling pathway we... | Our findings indicated that common genetic variants in TRAF6 were significantly associated with susceptibility to sepsis-induced ALI in Chinese Han population. This was the first genetic evidence supporting a role for TRAF6 in ALI. | yes |
22,903,907 | Does prevalence and correlate of anomalous experiences in a large non-clinical sample? | {
"contexts": [
"Anomalous experiences occur in many psychiatric conditions, but are also reported by non-patients. Given the continuum account of psychiatric symptoms and reports of dissociation between delusions and anomalous experiences, we predicted that anomalous experiences in a large non-clinical sample wo... | This large scale study demonstrated significant association between anomalous experiences and anomalous beliefs in the general population. The relationship was not, however present in all cases similar to cases reported in the clinical literature. | yes |
22,903,908 | Are adult attachment insecurities associated with obsessive compulsive disorder? | {
"contexts": [
"Obsessive compulsive disorder (OCD) is one of the most disabling and highly prevalent anxiety disorders (ADs). Current cognitive models of OCD implicate views about the self and world in the maintenance of the disorder. However, little research has focused on issues that may lead to vulnerability... | Addressing attachment anxiety in individuals presenting with OCD may be important for enhancing therapeutic outcomes. However, findings are based on cross-sectional data that preclude conclusions relating to causal influence. | yes |
22,901,915 | Does interleukin 8 correlate with intestinal involvement in surgically treated infants with necrotizing enterocolitis? | {
"contexts": [
"The aim of this study was to test the predictive value of interleukin (IL) 8 in the assessment of intestinal involvement in necrotizing enterocolitis (NEC).",
"Forty infants with surgically treated NEC were classified into 3 groups based on intestinal involvement during laparotomy: focal (n =... | To our knowledge, this is the first study to demonstrate a significant correlation of IL-8 with intestinal involvement in advanced NEC in a large patient population. Our results indicate that IL-8 may be a promising biomarker for assessing intestinal involvement in infants with advanced NEC. | yes |
22,907,189 | Does matrix metalloproteinase inhibitor COL-3 prevent the development of paclitaxel-induced hyperalgesia in mice? | {
"contexts": [
"To study the potential of chemically modified tetracycline-3 (COL-3), a potent matrix metalloproteinase (MMP) inhibitor, to protect against the development of paclitaxel-induced painful neuropathy and its immunomodulatory effects.",
"The reaction latency to thermal stimuli (hot plate test) of... | Our results indicate that the MMP inhibitor COL-3 protected against paclitaxel-induced thermal hyperalgesia and, thus, could be useful in the prevention of chemotherapy-induced painful neuropathy. | yes |
22,891,631 | Does baicalein attenuate impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation? | {
"contexts": [
"Whole-brain irradiation (WBI) therapy produces learning and memory deficits in patients with brain tumours. Although the pathological cascade of cognitive deficits remains unknown, it may involve reduced neurogenesis within the hippocampus. Baicalein is a flavonoid derived from the roots of Huang... | Our findings suggest that baicalein can be viewed as a potential therapeutic agent that protects against the impaired neurogenesis induced by WBI, and its neurocognitive consequences. | yes |
22,894,656 | Does the LCMV gp33-specific memory T cell repertoire narrow with age? | {
"contexts": [
"The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV disease. In contrast to studies focused on the number and surface phenotype of the memory c... | These data show that following LCMV infection the CD8+ gp33-specific CD8 T cell response becomes highly restricted with enormous narrowing of the diversity. This narrowing of the repertoire could contribute to the progressively ineffective immune response seen in aging. | yes |
22,885,840 | Does treatment of deep articular talus lesions by matrix associated autologous chondrocyte implantation -- result at five years? | {
"contexts": [
"Treatment of focal full-thickness chondral or osteochondral defects of the talus remains a challenge. The aim of this study was to evaluate the postoperative success and the long-term efficacy of matrix associated autologous chondrocyte implantation in these defects.",
"Matrix associated auto... | Matrix associated autologous chondrocyte implantation is capable of significant and stable long-term improvement of pain and functional impairment caused by focal full-thickness chondral and osteochondral talus lesions. | yes |
22,892,389 | Does the fatty acid synthase inhibitor orlistat reduce experimental metastases and angiogenesis in B16-F10 melanomas? | {
"contexts": [
"Fatty acid synthase (FASN) is overexpressed and associated with poor prognosis in several human cancers. Here, we investigate the effect of FASN inhibitors on the metastatic spread and angiogenesis in experimental melanomas and cultured melanoma cells.",
"The lung colonisation assay and cutan... | FASN inhibitors reduce metastasis and tumour-induced angiogenesis in experimental melanomas, and differentially modulate VEGFA expression in B16-F10 cells. | yes |
22,904,331 | Do a randomised cross-over cohort study of exposure to emissions from a road tunnel ventilation stack? | {
"contexts": [
"Road tunnels are increasingly important components of urban infrastructure. However, knowledge of their health impact on surrounding communities is limited. Our objective was to estimate the short-term respiratory health effects of exposure to emissions from a road tunnel ventilation stack.",
... | There was no consistent evidence of adverse respiratory effects from short-term exposures downwind of the tunnel ventilation stack, except for dry nose symptoms. However, the findings of increased airway inflammation and symptoms in subjects after only 2 h exposure at the heavily trafficked location, are suggestive of ... | yes |
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