pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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22,899,388 | Are blood pressure responses to acute and chronic exercise related in prehypertension? | {
"contexts": [
"Aerobic exercise is recommended as a way to prevent hypertension. However, about 25% of individuals receive minimal antihypertensive benefits associated with chronic exercise training. Thus, we attempt to identify those \"nonresponders\" to chronic exercise on the basis of their blood pressure (B... | The magnitude of the acute BP-lowering with exercise may predict the extent of BP lowering after chronic training interventions in prehypertensive individuals. | yes |
22,886,217 | Does [ Silencing of MST1 expression by siRNA diminish TNF-α- mediated human umbilical vein endothelial cell apoptosis ]? | {
"contexts": [
"To elucidate the effects of mammalian sterile 20-like kinase 1 (MST1) gene on tumor necrosis factor (TNF)-α-mediated human umbilical vein endothelial cell (HUVEC) apoptosis.",
"Cultured HUVECs were treated with either vehicle or TNF-α (1-100 ng/mL) for 24 hours. Cell apoptosis was measured by... | Silencing of MST1 expression by siRNA diminishes TNF-α-mediated human umbilical vein endothelial cell apoptosis by inhibiting the cascade effect of caspase-3. | yes |
22,905,137 | Is cholecystolithiasis associated with Clonorchis sinensis infection? | {
"contexts": [
"The objective of this study was to analyze gallbladder stones for direct evidence of a relationship between Clonorchis sinensis infection and gallbladder stones formation.",
"We investigated one hundred eighty-three gallbladder stones for the presence of Clonorchis sinensis eggs using microsc... | Clonorchis sinensis eggs were detected in the gallbladder stones which suggests an association between Clonorchis sinensis infection and gallbladder stones formation, especially pigment stones. | yes |
22,900,980 | Does human sulfatase-1 inhibit the migration and proliferation of SMMC-7721 hepatocellular carcinoma cells by downregulating the growth factor signaling? | {
"contexts": [
" The human sulfatase-1 (hSulf-1) gene regulates the sulfation of heparan sulfate proteoglycans (HSPG) and suppresses tumorigenesis and angiogenesis by inhibiting several growth factor signaling pathways. Because the serine-threonine protein kinase (AKT) and extracellular signal-regulated kinase ... | The expression of hSulf-1 mediated by adenovirus in HCC cells could downregulate the activity of AKT and ERK signaling pathways, and inhibit HCC cell migration and proliferation. The hSulf-1 gene may be considered as a candidate of antitumor factor for cancer gene therapy. | yes |
22,888,075 | Are prostate cancer treatments and their side effects associated with increased insomnia? | {
"contexts": [
"Between 25% and 40% of prostate cancer patients report insomnia symptoms. Although a possible role of androgen deprivation therapy (ADT) and radiation therapy (RTH) and some of their side effects have been postulated, this issue has rarely been investigated. This study aimed to (1) compare the ev... | Androgen deprivation therapy is associated with an increased risk for insomnia, and side effects of ADT and RTH appear to play a role in the development of insomnia in this population. | yes |
22,878,591 | Does advanced gestational age increase serum carbohydrate-deficient transferrin levels in abstinent pregnant women? | {
"contexts": [
"Carbohydrate-deficient transferrin (%CDT) is a well-established and highly specific biomarker for sustained heavy consumption of alcohol. However, in pregnant women, the specificity of this biomarker might be affected by advanced gestational age, even after accounting for increased transferrin co... | These results suggest that a conventional cutoff of 1.7% might be too low for pregnant women and would generate false-positive results. We propose that %CDT >2.0% be used as a cutoff concentration indicative of alcohol exposure in pregnant women. The sensitivity of %CDT at this cutoff for heavy drinking during pregnanc... | yes |
22,878,592 | Does the high angiogenic activity in very early breast cancer enable reliable imaging with VEGFR2-targeted microbubbles ( BR55 )? | {
"contexts": [
"Tumour xenografts of well-discernible sizes can be examined well by molecular ultrasound. Here, we investigated whether very early breast carcinomas express sufficient levels of VEGFR2 for reliable molecular ultrasound imaging with targeted microbubbles.",
"MCF-7 breast cancer xenografts were... | 3D molecular ultrasound using BR55 is very well suited to depicting the angiogenic activity in very small breast lesions, suggesting its potential for detecting and characterising these lesions. | yes |
22,882,326 | Are fOXE1 polymorphisms associated with familial and sporadic nonmedullary thyroid cancer susceptibility? | {
"contexts": [
"FOXE1 is a transcription factor required for thyroid differentiation and function. FOXE1 locus polymorphisms (chromosome 9q22.33) were recently associated with increased sporadic thyroid cancer risk. In this study, we aimed to investigate the association of FOXE1 variants with nonmedullary thyroi... | We found compelling evidence of association between FOXE1 variants and thyroid cancer risk in the Portuguese population. To our knowledge, this is the first study supporting the association of this locus with both sporadic and familial NMTC susceptibility. | yes |
22,908,098 | Does scatter spectroscopic imaging distinguish between breast pathologies in tissues relevant to surgical margin assessment? | {
"contexts": [
"A new approach to spectroscopic imaging was developed to detect and discriminate microscopic pathologies in resected breast tissues; diagnostic performance of the prototype system was tested in 27 tissues procured during breast conservative surgery.",
"A custom-built, scanning in situ spectro... | Localized scatter-imaging signatures detected by the scanning spectroscopy platform readily distinguished benign from malignant pathologies in surgical tissues and showed new spectral-spatial signatures of clinical breast pathologies. | yes |
22,883,053 | Does metabolic syndrome increase the risk of aggressive prostate cancer detection? | {
"contexts": [
"WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Metabolic syndrome can identify patients at high risk of cardiovascular disease. The prevalence of metabolic syndrome is increasing worldwide and is associated with increased age, obesity and hypogonadism. The association between metaboli... | MS seems not be associated with an increased risk of PC detection but it is associated with an increased risk of more aggressive tumours. | yes |
22,899,279 | Does mammalian target of rapamycin complex 2 regulate inflammatory response to stress? | {
"contexts": [
"To explore the role of mammalian target of rapamycin 2 (mTORC2) in the activation of inflammatory and oxidative responses in rodent models of acute injury and metabolic stress.",
"The impact of nephrilin, an inhibitor of mTORC2 complex, was assessed in three CD-1 mouse models of acute xenobio... | Taken together, our results suggest a role for mTORC2 in the inflammatory-oxidative responses to stress. | yes |
22,897,142 | Do extended interval dosing of gentamicin in premature neonates ≤ 28-week gestation? | {
"contexts": [
"To evaluate an extended interval dosing (EID) regimen of gentamicin in neonates ≤28-week gestation.",
"In 2008, an EID regimen for gentamicin was introduced for all neonates admitted to the NICU in Calgary. The dosing interval was based on a 22 h level after the first dose of 5mg/kg. We condu... | In neonates ≤ 28-week gestation, an EID regimen from day one of life, using a single level 22 h after the first dose for dosing interval, achieves therapeutic peak and trough levels and more optimum peak levels as compared to a TID regimen. | yes |
22,910,281 | Is novel nucleoside analogue FNC effective against both wild-type and lamivudine-resistant HBV clinical isolates? | {
"contexts": [
"HBV infection causes major public health problems worldwide. The clinical limitation of current antiviral drugs for HBV, such as lamivudine, is causing rapid emergence of drug-resistant viral strains during prolonged antiviral therapy. Therefore, new antiviral drugs are urgently needed to prevent... | FNC is a potential antiviral agent against both wild-type and lamivudine-resistant HBV clinical isolates, and therefore deserves further evaluation for the treatment of HBV infection. | yes |
22,904,292 | Does low injury rate strongly correlate with team success in Qatari professional football? | {
"contexts": [
"Although the incidence of football injuries should relate to team success there is little empirical evidence.",
"We investigated the relationship between injury incidence and team success in Qatar first-division football clubs.",
"Using a prospective cohort study design, we captured expos... | Lower incidence rate was strongly correlated with team success. Prevention of injuries may contribute to team success. | yes |
22,882,940 | Does in vivo administration of Fms-like tyrosine kinase-3 ligand effectively stimulate lung dendritic cell expansion in mice? | {
"contexts": [
"Dendritic cells (DCs) are the most important professional antigen presenting cells that play a key role in initiating adaptive immune responses. The depletion and dysfunction of DCs contribute to the development of immunodeficiency or immunoparalysis in some lung diseases. In the present study, w... | Flt3L administration in vivo induces lung DCs expansion, favoring myeloid and plasmacytoid DC subsets, which are phenotypically more mature. Flt3L may be useful in the therapy to augment immune function of the lung. | yes |
22,879,451 | Do aggregate health burden and the risk of hospitalization in older persons post hip replacement surgery? | {
"contexts": [
"We sought to understand the association between aggregate health burden-chronic conditions, functionally limiting health problems and mental well-being-and the likelihood of hospitalization among older persons post hip replacement surgery.",
"Eight hundred and twenty-eight Medicare recipients... | Several health domains predict hospitalization, beyond and including medical comorbidity. Efforts aimed at delaying/minimizing hospitalizations in this population should consider an array of domains for potentially targeted intervention. These findings can serve as a baseline against which future research can assess th... | yes |
22,879,455 | Does facial appearance reflect human familial longevity and cardiovascular disease risk in healthy individuals? | {
"contexts": [
"As facial appearance can be readily quantified and skin tissue easily accessed, they could be valuable tools for determining how biological mechanisms influence tissue degeneration with age and, consequently, human health and lifespan. It is unknown, however, whether appearance reflects disease r... | Facial appearance and skin wrinkling at a sun-protected site reflect the propensity to reach an extreme old age, and facial appearance reflects the risk of succumbing to CVD independently of chronological age, smoking, photodamage, and BMI. | yes |
22,883,482 | Is dementia strongly associated with 90-day mortality in lobar cerebral amyloid angiopathy related intra-cerebral haemorrhage? | {
"contexts": [
"While evidence suggests that lobar intracerebral haemorrhage (ICH) is linked with dementia and cognitive impairment, the association between cognition and mortality risk from ICH is unclear.",
"To examine the association between dementia or cognitive impairment and short- and medium-term mort... | A history of dementia or cognitive impairment is more common in lobar CAA-related ICH and it is a medium-term mortality predictor in lobar ICH but not in deep non-lobar ICH. | yes |
22,883,484 | Are patients with Lynch syndrome mismatch repair gene mutations at higher risk for not only upper tract urothelial cancer but also bladder cancer? | {
"contexts": [
"Lynch syndrome (LS), or hereditary nonpolyposis colorectal cancer, is caused by mutations in mismatch repair (MMR) genes. An increased risk for upper tract urothelial carcinoma (UTUC) has been described in this population; however, data regarding the risk for bladder cancer (BCa) are sparse.",
... | Eleven of 177 patients with MSH2 mutations (6.21%, p<0.001 compared with the Canadian population) were found to have BCa, compared with 3 of 129 patients with MLH1 mutations (2.32%, p>0.05). Of these 11 tumors, 81.8% lacked expression of MSH2 on IHC, compared with the matched sporadic cases, which all displayed normal ... | yes |
22,910,327 | Does systematic evaluation of Axis-I DSM diagnose in delayed sleep phase disorder and evening-type circadian preference? | {
"contexts": [
"Alterations in circadian rhythms can have profound effects on mental health. High co-morbidity for psychiatric disorders has been observed in patients with circadian rhythm disorders, such as delayed sleep phase disorder (DSPD), and in those with an evening-type circadian preference. The aim of t... | These results highlight the important link between circadian rhythms and mental disorders. Specifically, an evening circadian chronotype regardless of DSPD status is associated with a risk for anxiety, depressive or substance-use disorders. | yes |
22,893,547 | Does high frequency electrical stimulation concurrently induce central sensitization and ipsilateral inhibitory pain modulation? | {
"contexts": [
"In healthy humans, analgesia to blunt pressure develops in the ipsilateral forehead during various forms of limb pain. The aim of the current study was to determine whether this analgesic response is induced by ultraviolet B radiation (UVB), which evokes signs of peripheral sensitization, or by h... | HFS conditioning induced signs of central sensitization in the forearm and analgesia both in the ipsilateral forehead and the HFS-treated site. This ipsilateral analgesia was not due to peripheral sensitization or other non-specific effects, as it failed to develop after UVB conditioning. Thus, the supra-spinal mechani... | yes |
22,889,511 | Does l-Arginine enhance glucose and lipid metabolism in rat L6 myotubes via the NO/ c-GMP pathway? | {
"contexts": [
"The amino acid Arginine (Arg) is the main biological precursor of nitric oxide (NO) and has been described to improve insulin sensitivity in diabetes and obesity. We investigated the molecular mechanisms involved in the long-term effects of Arg on glucose and lipid metabolism.",
"L6 myotubes ... | We provide evidence that Arg improves glucose and lipid metabolism in skeletal muscle, in parallel with increased phosphorylation of Akt and AMPK-α. These effects were mediated by the NO/c-GMP pathway. Thus, arginine treatment enhances signal transduction and has a beneficial effect of metabolism in skeletal muscle thr... | yes |
22,898,769 | Does acute exposure to resveratrol inhibit AMPK activity in human skeletal muscle cells? | {
"contexts": [
"Recent studies have suggested resveratrol (RSV) as a new natural therapeutic agent to treat type 2 diabetes and lipid-induced insulin resistance. Here, we investigated whether RSV could reverse palmitate-induced insulin resistance in human primary muscle cells.",
"Myotubes obtained from six h... | Acute exposure to RSV inhibits AMPK activity, fatty-acid oxidation and glucose metabolism in human myotubes. | yes |
22,908,206 | Are cardiovascular diseases largely underreported in Danish centenarians? | {
"contexts": [
"the substantial decline in oldest old mortality has led to more people surviving to very old age. As morbidity and disability generally increases with age epidemiological research in ageing has focused on the health of oldest olds. However, most studies are based on self-reported or physician-rep... | self-reported information largely underestimates the CVD life-time prevalence in Danish centenarians. Objective clinical examinations are necessary to evaluate true disease prevalence in oldest old. | yes |
22,878,869 | Does penehyclidine enhance the efficacy of tropisetron in prevention of PONV following gynecological laparoscopic surgery? | {
"contexts": [
"Postoperative nausea and vomiting (PONV) are common complications after gynecological laparoscopic surgery. Because monotherapy with antiemetics is insufficient, combinations of various antiemetics are often recommended by experts. In this study, our purpose was to find out whether penehyclidine ... | Penehyclidine showed less efficacy in preventing PONV than tropisetron; however, compared with tropisetron or penehyclidine monotherapy, prophylactic medication with tropisetron plus penehyclidine significantly reduced the incidence of vomiting and decreased the intensity of nausea in women undergoing gynecological lap... | yes |
22,878,868 | Does nicotine treatment improve Toll-like receptor 2 and Toll-like receptor 9 responsiveness in active pulmonary sarcoidosis? | {
"contexts": [
"New evidence links nicotine to the regulation of T cell-mediated inflammation via a 7 nicotinic cholinergic receptor activation, and chronic nicotine exposure (smoking) reduces the incidence of granulomatous diseases. We sought to determine whether nicotine treatment was well tolerated while effe... | Nicotine treatment in active pulmonary sarcoidosis was well tolerated and restored peripheral immune responsiveness to TLR2 and TLR9 agonists and expansion of FoxP3 1 Tregs, including a specific “preactivated” (CD25 2 ) phenotype. The immune phenotype of patients with symptomatic sarcoidosis treated with nicotine close... | yes |
22,907,263 | Does citrus limonin lack the antichemotherapeutic effect in human models of breast cancer? | {
"contexts": [
"Chemicals that interfere with reactive oxygen species metabolism can act as potential candidates for the treatment of cancer. Some of the glucosides of citrus limonin inhibit the endogenously generated reactive oxygen species. The aim is to study the interactions of limonin with chemotherapy.",
... | Both in vitro and in vivo results suggest that limonin could be beneficial for breast cancer patients undergoing chemotherapy. | yes |
22,909,062 | Is induction of interleukin-10 dependent on p38 mitogen-activated protein kinase pathway in macrophages infected with porcine reproductive and respiratory syndrome virus? | {
"contexts": [
"Porcine reproductive and respiratory syndrome virus (PRRSV) causes reproductive failure and respiratory illness in pigs and usually establishes a persistent infection. Previous studies suggested that interleukin-10 (IL-10) could play a critical role in PRRSV-induced immunosuppression. However, th... | PRRSV strain CH-1a could significantly up-regulate IL-10 production through p38 MAPK activation. | yes |
22,878,035 | Is [ Aortic valve stenosis associated with reduced myocardial perfusion as assessed by videodensitometry in coronary angiograms ]? | {
"contexts": [
"Aortic valve stenosis may be accompanied by angina despite coronary arteries free of significant stenosis due to microvascular abnormalities.",
"The aim of the current study was to test whether densitometry-derived myocardial perfusion on coronary angiogram is reduced in patients with aortic ... | Reduced Gmax/Tmax values indicative of myocardial perfusion abnormalities as measured by densitometry on coronary angiograms could be demonstrated in patients with aortic valve stenosis compared to controls. | yes |
22,889,605 | Is atenolol associated with lower day-of-surgery heart rate compared to long- and short-acting metoprolol? | {
"contexts": [
"The authors analyzed the association between outpatient β-blocker type and day-of-surgery (DOS) heart rate in ambulatory surgical patients. They further investigated whether differences in DOS heart rate between atenolol and metoprolol could be explained by once-daily versus twice-daily dosing re... | Atenolol is associated with a lower DOS heart rate versus metoprolol. The heart rate difference is specific to the day of surgery and is not explained by once-daily versus twice-daily dosing regimens. | yes |
22,888,823 | Is parental attention to their child 's pain modulated by threat-value of pain? | {
"contexts": [
"The present study investigated parental attention and sensitivity to their child's pain and the moderating role of child's facial pain expressiveness and induced threat.",
"Sixty-two parents (49 mothers; 13 fathers) of schoolchildren observed their child undergoing painful and nonpainful heat... | These findings attest to the importance of pain-related threat in understanding parent attention to child pain. Theoretical and clinical implications and future research directions are discussed. | yes |
22,906,692 | Does preinjury beta blocker usage affect the heart rate response to initial trauma resuscitation? | {
"contexts": [
"The effect of preinjury beta blockade on heart rate during initial trauma resuscitation is unclear. We hypothesized that preinjury beta blockade does not affect the heart rate response to initial trauma resuscitation.",
"A case-control study of patients admitted to a level I trauma center was... | Preinjury beta blockade is associated with a slower presenting heart rate, more bradycardia, less tachycardia, but no difference in mortality or ability to achieve a normal heart rate with resuscitation. | no |
22,897,373 | Does serum leptin level have a positive correlation with BMI and creatinine clearance in CAPD patients? | {
"contexts": [
"In a cross sectional study, 75 patients (42 males and 33 females) on continuous ambulatory peritoneal dialysis (CAPD) were enrolled from October 2007 to February 2008. Serum levels of leptin, albumin, triglyceride, dialysis adequacy (total KT/V), renal creatinine clearance (Cr Cl), mid arm circum... | To our knowledge, this is probably the first study to report that serum leptin level has a direct positive correlation with renal Cr Cl in CAPD patients. This may explain the increase in mortality in patients with lower serum leptin levels (Tab. 2, Fig. 2, Ref. 25). | yes |
22,885,239 | Does raman spectroscopy demonstrate Amifostine induced preservation of bone mineralization patterns in the irradiated murine mandible? | {
"contexts": [
"Adjuvant radiotherapy in the management of head and neck cancer remains severely debilitating. Fortunately, newly developed agents aimed at decreasing radiation-induced damage have shown great promise. Amifostine (AMF) is a compound, which confers radio-protection to the exposed normal tissues, s... | Our novel findings demonstrate that AMF prophylaxis maintains and protects bone mineral quality in the setting of radiation. Raman spectroscopy is an emerging and exceptionally attractive clinical translational technology to investigate and monitor both the destructive effects of radiation and the therapeutic remediati... | yes |
22,884,189 | Does interval training confer greater gains than continuous training in people with heart failure? | {
"contexts": [
"Is aerobic interval training (AIT) more effective than moderate continuous training (MCT) at enhancing aerobic fitness and myocardial remodelling in patients with stable heart failure?",
"Randomised controlled trial in which participants were allocated to AIT, MCT, or a control group.",
"... | In adults with stable heart failure, AIT conferred greater gains than MCT in improving aerobic capacity and measures reflecting left ventricular and endothelial function. [Mean difference and 95% CIs calculated by the CAP Editor]. | yes |
22,888,987 | Does towards biological characters of interactions between transcription factors and their DNA target in mammals? | {
"contexts": [
"In post-genomic era, the study of transcriptional regulation is pivotal to decode genetic information. Transcription factors (TFs) are central proteins for transcriptional regulation, and interactions between TFs and their DNA targets (TFBSs) are important for downstream genes' expression. Howeve... | Our work demonstrates that, to some extent, TFs and TFBSs have developed a coevolutionary relationship in order to keep their physical binding and maintain their regulatory functions. In summary, our work will help understand transcriptional regulation and interpret binding mechanism between proteins and DNAs. | yes |
22,906,244 | Does patient education level affect functionality and long term mortality after major lower extremity amputation? | {
"contexts": [
"The aim of this study was to examine the relationship between patient education level and 5-year mortality after major lower extremity amputation.",
"The records of all patients who underwent above-knee or below-knee amputation at the Nashville Veterans Affairs Medical Center by the vascular ... | Patients with less education have increased long-term mortality after lower extremity amputation. | yes |
22,898,271 | Does failure of delayed nonsynaptic neuronal plasticity underlie age-associated long-term associative memory impairment? | {
"contexts": [
"Cognitive impairment associated with subtle changes in neuron and neuronal network function rather than widespread neuron death is a feature of the normal aging process in humans and animals. Despite its broad evolutionary conservation, the etiology of this aging process is not well understood. H... | The results identify the CGCs as cellular loci of age-associated appetitive learning and memory impairment in Lymnaea and buttress the hypothesis that lipid peroxidation-dependent depression of intrinsic excitability is a hallmark of normal neuronal aging. The data implicate both lipid peroxidation-dependent non-synapt... | yes |
22,879,891 | Does osteopontin reduce biofilm formation in a multi-species model of dental biofilm? | {
"contexts": [
"Combating dental biofilm formation is the most effective means for the prevention of caries, one of the most widespread human diseases. Among the chemical supplements to mechanical tooth cleaning procedures, non-bactericidal adjuncts that target the mechanisms of bacterial biofilm formation have ... | OPN strongly reduces the amount of biofilm formed in a well-defined laboratory model of acidogenic dental biofilm. If a similar effect can be observed in vivo, OPN might serve as a valuable adjunct to mechanical tooth cleaning procedures. | yes |
22,879,899 | Does maternal nutritional status predict adverse birth outcomes among HIV-infected rural Ugandan women receiving combination antiretroviral therapy? | {
"contexts": [
"Maternal nutritional status is an important predictor of birth outcomes, yet little is known about the nutritional status of HIV-infected pregnant women treated with combination antiretroviral therapy (cART). We therefore examined the relationship between maternal BMI at study enrollment, gestati... | In our cohort of HIV-infected women initiating cART during pregnancy, grossly inadequate GWG was common. Infants whose mothers gained <0.1 kg/week were at increased risk for LBW, preterm delivery, and composite adverse birth outcomes. cART by itself may not be sufficient for decreasing the burden of adverse birth outco... | yes |
22,884,916 | Is liver fat content associated with increased carotid atherosclerosis in a Chinese middle-aged and elderly population : the Shanghai Changfeng study? | {
"contexts": [
"Nonalcoholic fatty liver disease is closely associated with metabolic syndrome and cardiovascular disease (CVD). We investigated whether the liver fat content (LFC) is independently associated with carotid artery intima-media thickness (CIMT) and evaluated the contribution of the LFC to the incre... | These results suggest that the LFC is independently associated with carotid atherosclerosis in the Chinese population, and that the risk of atherosclerosis is proportional to the degree of hepatic steatosis. | yes |
22,908,954 | Do metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model? | {
"contexts": [
"Duchenne muscular dystrophy is a genetic disease involving a severe muscle wasting that is characterized by cycles of muscle degeneration/regeneration and culminates in early death in affected boys. Mitochondria are presumed to be involved in the regulation of myoblast proliferation/differentiati... | The three treatments produced significant improvements in disease phenotype, including an increase in overall behavioral activity and significant gains in forelimb and hind limb strength. Our findings suggest that triggering mitochondrial activity with exercise mimetics improves muscle function in dystrophin-deficient ... | yes |
22,900,789 | Are common stressful life events and difficulties associated with mental health symptoms and substance use in young adolescents? | {
"contexts": [
"Stressful life events are associated with mood disorders in adults in clinical settings. Less described in the literature is the association between common life stressors and a wide range of psychopathology in young adolescents. This study uses a large non-clinical sample of young adolescents to ... | Young adolescents may benefit from learning positive coping skills to manage worry or stress about common stressors and in particular, worry or stress related to romantic breakups. Appropriate management of mental health symptoms and substance use related to common stressful life events and difficulties may help reduce... | yes |
22,878,964 | Is p.R4810K , a polymorphism of RNF213 , the susceptibility gene for moyamoya disease , associated with blood pressure? | {
"contexts": [
"Moyamoya disease-an idiopathic vascular disorder of intracranial arteries-is often accompanied by hypertension. RNF213 has been identified as a susceptibility gene for moyamoya disease. In the present study, the association of p.R4810K (G>A) with blood pressure (BP) was investigated in a Japanese... | Our study suggests that p.R4810K of RNF213 is associated strongly with systolic BP. | yes |
22,897,479 | Is hypoalbuminaemia an independent predictor for hemophagocytic lymphohistiocytosis in childhood Epstein-Barr virus-associated infectious mononucleosis? | {
"contexts": [
"Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal condition in children with Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). This study aimed to identify commonly available clinical and laboratory predictors that might help clinicians decide to perform the bone ma... | Hypoalbuminaemia is a unique characteristic and potentially a valuable predictor for HLH in paediatric EBV-associated IM. | yes |
22,897,492 | Is achievement of client-centred goals by persons with acquired brain injury in comprehensive day treatment associated with improved functional outcomes? | {
"contexts": [
"To study the relationship between goal achievement and vocational and independent living at discharge and 1-year follow-up in persons with acquired brain injury (ABI) participating in a Comprehensive Day Treatment (CDT) programme.",
"A retrospective review of longitudinal data.",
"One hun... | The results demonstrate that achievement of individualized CDT graduation goals is associated with greater levels of vocational and residential independence following acquired brain injury. | yes |
22,898,068 | Does sequence variation confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria? | {
"contexts": [
"Plasmodium falciparum histidine-rich protein PFHRP2 measurement is used widely for diagnosis, and more recently for severity assessment in falciparum malaria. The Pfhrp2 gene is highly polymorphic, with deletion of the entire gene reported in both laboratory and field isolates. These issues poten... | These findings indicate that sequence polymorphism is not a significant cause of variation in PFHRP2 concentration in plasma samples from African children. This justifies the further development of plasma PFHRP2 concentration as a method for assessing African children who may have severe falciparum malaria. The data al... | no |
22,890,276 | Are long-range inhibitory mechanisms in the visual system impaired in migraine sufferers? | {
"contexts": [
"After viewing dynamic noise surrounding a homogeneous grey patch (artificial scotoma), observers perceive a prolonged twinkling-noise after-image within the unstimulated area. It has been suggested that noise-stimulated neurons induce a long-range inhibition in neurons within the artificial scoto... | Enhanced excitation of noise-activated neurons in migraineurs would produce stronger rebound activity and longer after-image durations, while weakened inhibitory mechanisms would diminish the rebound activity and shorten the after-image durations compared to control subjects. The results suggest that cortical inhibitor... | yes |
22,889,980 | Is creatinine clearance associated with toxicity from molecularly targeted agents in phase I trials? | {
"contexts": [
"This study aimed to evaluate any correlations between baseline creatinine clearance and the development of grade 3/4 toxicities during treatment within oncology phase I trials of molecularly targeted agents where entry criteria mandate a serum creatinine of ≤ 1.5 × the upper limit of normal.",
... | Creatinine clearance (even when within normal limits) should be studied as a potential factor influencing late toxicities in the clinical trials of molecularly targeted anti-cancer drugs. | yes |
22,889,981 | Does apigenin inhibit NNK-induced focal adhesion kinase activation in pancreatic cancer cells? | {
"contexts": [
"Tobacco-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) activates β-adrenergic receptor (β-AR) signaling through Src/focal adhesion kinases (FAKs)/mitogen-activated protein kinase to modulate proliferation, migration, and survival. Apigenin (4', 5, 7-trihydroxyflavone) is ... | Apigenin suppressed the effects of NNK on pancreatic cancer cell proliferation and migration that are mediated through the β-AR and its downstream signals FAK and ERK activation. These findings suggest a therapeutic role for this natural phytochemical in attenuating the procarcinogenic effects of NNK on pancreatic canc... | yes |
22,903,392 | Does chronic cannabinoid exposure reduce phencyclidine-induced schizophrenia-like positive symptoms in adult rats? | {
"contexts": [
"Chronic cannabis use can induce psychotic states that resemble schizophrenia. Yet, schizophrenic patients often smoke cannabis as a form of self-medication to counter the aversive symptoms of schizophrenia. We recently demonstrated an ameliorating effect of cannabinoid self-administration (SA) on... | Our results indicate that cannabis may exert protective effects on positive schizotypic symptoms in adult animals such as hypermotility and anxiety state. | yes |
22,886,447 | Are changes in novel biomarkers of disease activity in juvenile and adult dermatomyositis sensitive biomarkers of disease course? | {
"contexts": [
"Muscle enzyme levels are insensitive markers of disease activity in juvenile and adult dermatomyositis (DM), especially during the active treatment phase. To improve our ability to monitor DM disease activity longitudinally, especially in the presence of immunomodulating agents, we prospectively ... | Our findings suggest that changes in type I IFN gene and chemokine scores as well as in levels of IL-6, IL-8, and TNFα may serve as sensitive and responsive longitudinal biomarkers of change in disease activity in juvenile and adult DM, even in the presence of immunomodulating agents. | yes |
22,891,033 | Does multiparametric MRI correlate of sensorimotor function in the spinal cord in multiple sclerosis? | {
"contexts": [
"Spinal cord (SC) pathology is a major contributor to clinical disability in multiple sclerosis (MS). Conventional magnetic resonance imaging (MRI), specifically SC-MRI lesion load measures that include lesion count and volume, demonstrate only a modest relationship with the clinical status of MS ... | In a large, heterogeneous MS sample, quantitative SC-MRI indices demonstrated independent associations with system-specific and global clinical dysfunction. Our findings suggest that the indices studied may provide important information about microstructural SC changes and the substrates of limb disability in MS. The i... | yes |
22,889,864 | Does aromatase gene polymorphism influence clinical phenotype and response to oral contraceptive pills in polycystic ovary syndrome women? | {
"contexts": [
"To assess whether a single nucleotide polymorphism (SNP50) of the aromatase gene (CYP19) is associated with polycystic ovary syndrome (PCOS) phenotypes and to investigate the influence of this polymorphism on the response of PCOS to treatment with oral contraceptive pills (OCP).",
"162 hirsut... | The differences between c-PCOS and ov-PCOS cannot be explained by the genetic variation at SNP50 in the CYP19 gene. | no |
22,898,004 | Is laminin-5 a biomarker of invasiveness in cervical adenocarcinoma? | {
"contexts": [
"Glandular lesions are often problematic for diagnostic cervical pathology. The survival of patients with adenocarcinoma is significantly poorer than that of patient with squamous cell carcinoma. One reason for this increased risk is the aggressive invasiveness of adenocarcinoma. Therefore additio... | We conclude that Lam-5 is a useful biomarker in the evaluation of invasiveness in cervical adenocarcinoma. | yes |
22,902,870 | Does hepatic vascular endothelial growth factor regulate recruitment of rat liver sinusoidal endothelial cell progenitor cells? | {
"contexts": [
"After liver injury, bone marrow-derived liver sinusoidal endothelial cell progenitor cells (BM SPCs) repopulate the sinusoid as liver sinusoidal endothelial cells (LSECs). After partial hepatectomy, BM SPCs provide hepatocyte growth factor, promote hepatocyte proliferation, and are necessary for ... | BM SPC recruitment is a repair response to dimethylnitrosamine liver injury in rats. Hepatic VEGF regulates recruitment of BM SPCs to liver and reduces this form of liver injury. | yes |
22,902,871 | Is impaired formation of vasodilators in peripheral tissue in essential hypertension normalized by exercise training : role of adenosine and prostacyclin? | {
"contexts": [
"This study examined vascular function and the adenosine system in skeletal muscle of patients diagnosed with essential hypertension (n = 10) and of normotensive (n = 11) patients, before and after aerobic training.",
": Before and after 8 weeks of aerobic training, the patients completed expe... | The present data suggest that essential hypertension is associated with a reduced capacity to form adenosine and PGI2 at the skeletal muscle microcirculatory level, which is likely to contribute to the increased peripheral vascular resistance related to the disease. This impairment in vasodilator formation can be norma... | yes |
22,877,896 | Are low serum free triiodothyronine levels associated with the presence and severity of coronary artery disease in the euthyroid patients : an observational study? | {
"contexts": [
"The aim of this study is to investigate the relationship between serum thyroid hormone levels that are within the normal range and the presence and severity of coronary artery disease (CAD) in patients referred for coronary angiography.",
"In this observational study, we enrolled 119 consecut... | FT3 levels within the normal range were inversely correlated with the presence and severity of CAD. Moreover, lower FT3 concentrations were correlated with the Gensini score and independently predicted the presence and severity of CAD. Thus, the FT3 levels may be used as the indicator of increased risk for CAD. | yes |
22,879,581 | Does nanoparticle-mediated delivery of pioglitazone enhance therapeutic neovascularization in a murine model of hindlimb ischemia? | {
"contexts": [
"Critical limb ischemia is a severe form of peripheral artery disease (PAD) for which neither surgical revascularization nor endovascular therapy nor current medicinal therapy has sufficient therapeutic effects. Peroxisome proliferator activated receptor-γ agonists present angiogenic activity in v... | NP-mediated drug delivery is a novel modality that may enhance the effectiveness of therapeutic neovascularization, surpassing the effectiveness of current treatments for peripheral artery disease with critical limb ischemia. | yes |
22,879,582 | Do adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus-related endothelial dysfunction in humans? | {
"contexts": [
"Mitochondrial dysfunction plays a key pathophysiological role in type 2 diabetes mellitus (T2DM). Data delineating relationships between mitochondrial and endothelial dysfunction in humans with T2DM are lacking.",
"In 122 human subjects (60 with T2DM, 62 without T2DM), we measured endothelial... | Mitochondrial dysfunction may play a central role in the impairment of endothelial dysfunction in T2DM. | yes |
22,882,023 | Does oNO-2506 inhibit spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation? | {
"contexts": [
"Anticonvulsants have been developed according to the traditional neurotransmission imbalance hypothesis. However, the anticonvulsive pharmacotherapy currently available remains unsatisfactory. To develop new antiepileptic drugs with novel antiepileptic mechanisms, we have tested the antiepileptic... | ONO-2506 did not affect traditional convulsive tests but markedly inhibited epileptic phenomena in the genetic epilepsy mouse model. ONO-2506 enhanced release of inhibitory neuro- and gliotransmitters during the resting stage and inhibited tripartite transmission during the hyperactive stage. The results suggest that O... | yes |
22,902,186 | Is a better diet quality associated with a reduced likelihood of CKD in older adults? | {
"contexts": [
"Studies of diet in relation to chronic kidney disease (CKD) have focused on individual nutrients. The relationship between overall patterns of food intake and renal function has not been well explored. We aimed to investigate the associations between diet quality with the prevalence, incidence an... | Older adults with better diet quality had a reduced likelihood of having eGFR <60 mL min⁻¹·1.73 m⁻². Adherence to dietary guidelines were not prospectively associated with CKD incidence or progression. Further studies with adequate power are warranted to assess the longitudinal association between diet quality and CKD. | yes |
22,880,806 | Does peripheral arterial disease predict overall and cardiovascular mortality in peritoneal dialysis patients? | {
"contexts": [
"Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis and is common among dialysis patients. Cardiovascular disease (CVD) accounts for the leading cause of mortality in dialysis patients, and PAD has been found as a predictor for cardiovascular as well as ove... | PAD is very common in aged peritoneal dialysis patients and independently associated with both cardiovascular and overall mortality. | yes |
22,880,801 | Is platelet glycoprotein IIb HPA-3 a/b polymorphism associated with native arteriovenous fistula thrombosis in chronic hemodialysis patients? | {
"contexts": [
"The aim of this study was to investigate the association of Glycoprotein IIb (GPIIb) human platelet antigen-3 (HPA-3) a/b polymorphism with end-stage renal disease (ESRD) on hemodialysis (HD) and native Arteriovenous fistula (AVF) thrombosis.",
"The polymorphism in the GPIIb subunit of the re... | These findings suggest an association between AVF thrombosis and the HPA-3b allele, and it is likely that HPA-3 a/b polymorphisms could be useful markers for potential risk of native AVF thrombosis in HD patients. | yes |
22,880,808 | Does chronic renal failure impact the expression of ghrelin and its receptor in hypothalamus and hippocampus? | {
"contexts": [
"Ghrelin plays a central role in the regulation of gastrointestinal (GI) motility. This study aimed to investigate the expression of ghrelin and growth hormone secretagogue receptor (GHSR) in the central nervous system of rats with chronic renal failure (CRF).",
"Sprague-Dawley rats (male, 180... | CRF was found to impact the expression of ghrelin and GHSR in hypothalamus and hippocampus. This might be associated with the CRF-induced GI motility dysfunction. | yes |
22,890,015 | Does inflammation-based prognostic score predict survival in patients with advanced gastric cancer receiving biweekly docetaxel and s-1 combination chemotherapy? | {
"contexts": [
"This study was conducted to determine the prognostic value of the Glasgow Prognostic Score (GPS), an inflammation-based prognostic score composed of C-reactive protein and albumin, for patients with advanced cancer.",
"A total of 83 advanced gastric cancer patients receiving biweekly docetaxe... | In the low GPS group, it may be possible to obtain favorable outcomes by chemotherapy in advanced gastric cancer patients. However, a well-designed prospective trial in a large patient cohort is required to corroborate the prognostic value of the GPS. | yes |
22,902,986 | Does bovine lactoferrin improve bone mass and microstructure in ovariectomized rats via OPG/RANKL/RANK pathway? | {
"contexts": [
"Lactoferrin (LF), an 80-kDa iron-binding glycoprotein, is a pleiotropic factor found in colostrum, milk, saliva and epithelial cells of the exocrine glands. The aim of this study was to evaluate the effects of LF on the bones in ovariectomized (Ovx) rats and to identify the pathways that mediate ... | Oral administration of LF preserves the bone mass and improves the bone microarchitecture. LF enhances bone formation, reduces bone resorption, and decreases bone mass loss, possibly through the regulation of OPG/RANKL/RANK pathway. | yes |
22,882,270 | Is a subset of human uterine endometrial macrophages alternatively activated? | {
"contexts": [
"Human uterine macrophages must maintain an environment hospitable to implantation and pregnancy and simultaneously provide protection against pathogens. Although macrophages comprise a significant portion of leukocytes within the uterine endometrium, the activation profile and functional response... | A major population of human uterine macrophages is alternatively activated. These cells secrete factors in response to LPS that are involved in the activation of immune responses and tissue homeostasis. | yes |
22,887,988 | Do impacts of infancy rapid weight gain on 5-year childhood overweight development vary by age and sex in China? | {
"contexts": [
"To investigate the critical period for overweight development during early childhood by examining growth trajectory and related sex differences.",
"Using piecewise linear mixed models and logistic regression, we examined the effect of growth trajectory at different periods on overweight at ag... | Overweight risk develops during the first 3 months of life. Boys have an earlier peak in growth than girls, which may help explain why overweight is more prevalent in boys in China. | yes |
22,904,274 | Does monocyte chemoattractant protein-1/CCR2 axis promotes vein graft neointimal hyperplasia through its signaling in graft-extrinsic cell populations? | {
"contexts": [
"To evaluate direct versus indirect monocyte chemoattractant protein (MCP)-1/CCR2 signaling and to identify the cellular producers and effectors for MCP-1 during neointimal hyperplasia (NIH) development in vein grafts.",
"Genomic analysis revealed an overrepresentation of 13 inflammatory pathw... | MCP-1/CCR2 axis accelerates NIH via its signaling in graft-extrinsic cells, particularly circulating inflammatory cells, with cells both intrinsic and extrinsic to the graft wall being critical MCP-1 producers. These findings underscore the importance of systemic treatment for anti-MCP-1/CCR2 therapies. | yes |
22,904,275 | Does elevated CETP activity improve plasma cholesterol efflux capacity from human macrophages in women? | {
"contexts": [
"We aim to identify the impact of endogenous cholesteryl ester transfer protein (CETP) activity on plasma capacity to mediate free cholesterol efflux from human macrophages.",
"Endogenous plasma CETP activity was measured in a population of 348 women. We defined a low CETP group corresponding ... | CETP leading to the improvement of plasma efflux capacity, as a result of efficient pre-β-high-density lipoprotein formation and ATP-binding cassette transporter A1 efflux, should be preserved to prevent lipid accumulation in human macrophages. | yes |
22,904,271 | Does a disintegrin and metalloproteinase 15 contribute to atherosclerosis by mediating endothelial barrier dysfunction via Src family kinase activity? | {
"contexts": [
"Endothelium dysfunction is an initiating factor in atherosclerosis. A disintegrin and metalloproteinase 15 (ADAM 15) is a multidomain metalloprotease recently identified as a regulator of endothelial permeability. However, whether and how ADAM15 contributes to atherosclerosis remains unknown.",
... | These results suggest that endothelial cell-derived ADAM15, signaling through c-Src and c-Yes, contributes to atherosclerotic lesion development by disrupting adherens junction integrity and promoting monocyte transmigration. | yes |
22,904,273 | Does endogenous renovascular hypertension combined with low shear stress induce plaque rupture in apolipoprotein E-deficient mice? | {
"contexts": [
"The development of a murine model of spontaneous atherosclerotic plaque rupture with luminal thrombus.",
"Combined partial ligation of the left renal artery and left common carotid artery in 8-week-old apolipoprotein E-deficient mice induced endogenous renovascular hypertension and local low ... | We demonstrate a murine model of spontaneous plaque rupture with a high incidence of luminal thrombus. The model not only nicely recapitulates the pathophysiological processes of human plaque rupture but it is also simple, fast, and highly efficient to generate. | yes |
22,902,319 | Is injury risk different in team and individual youth sport? | {
"contexts": [
"This study compared sports injury incidence in young high-level athletes from various team and individual sports and investigated if sport participation patterns are linked to injuries.",
"Prospective cohort follow-up.",
"Pupils from a public sports school (12-19 years) were recruited ove... | Team sports participation entailed a higher injury risk, whatever the injury category. Further research should elucidate the role of characteristics related to sport participation in injury causation. | yes |
22,888,065 | Does health-related quality of life differ between short-term , long-term and very long-term cancer survivors in the Swedish general population? | {
"contexts": [
"Time since cancer diagnosis is rarely accounted for in population-based studies of health-related quality of life (HRQL) among cancer survivors. Therefore, this study aimed to assess the relationship between time since cancer diagnosis and impairments in HRQL among short-term, long-term and very ... | Although HRQL was similar between short-term, long-term and very long-term survivors, when compared with the background population, findings suggest that some functional impairments and symptoms are present even at 5-10 YSD. | no |
22,884,659 | Is the expression of estrogen receptors as well as GREB1 , c-MYC , and cyclin D1 , estrogen-regulated genes implicated in proliferation , increased in peritoneal endometriosis? | {
"contexts": [
"To analyze the expression of estrogen receptors α and β as well as their target genes implicated in proliferation, c-myc, cyclin D1, and GREB1, in the endometrium of women with or without endometriosis.",
"Expression analysis in human tissue.",
"University hospitals and a clinic.",
"N... | This constitutes the first report of increased expression of GREB1, as well as cyclin D1 and c-myc, in peritoneal endometriotic lesions, implicating these proteins in estrogen-dependent growth in this context. | yes |
22,889,273 | Do single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1? | {
"contexts": [
"The mechanism by which HIV-1 induces AIDS is still unknown. Previously, synthetic peptides corresponding to the conserved immunosuppressive (isu) domain in gp41 of HIV-1 had been shown to inhibit proliferation and to modulate cytokine expression of immune cells. The question is, whether the viral... | These findings indicate that the isu domain of gp41 modulates cytokine expression in vitro and suppresses antibody response in vivo and therefore may contribute to the virus induced immunodeficiency. | yes |
22,907,286 | Do clinical and molecular effects on mature burn scars after treatment with a fractional CO ( 2 ) laser? | {
"contexts": [
"There have been several case reports of improvement in the appearance of mature burn scars following treatment with fractional CO(2) lasers. However, the biochemical mechanisms responsible for these improvements have not been elucidated.",
"Ten patients with mature, full-thickness, hypertroph... | Our study indicated that fractional CO(2) resulted in clinical improvement of mature burn scar. Alteration of types I and III procollagen, MMP-1, TGF-β2, -β3, bFGF, as well as miRNAs miR-18a and miR-19a expression may be responsible for the clinical improvement after treatment. Our finding may have implications for nov... | yes |
22,887,906 | Does uV-C-irradiation sublethal stress alter antibiotic susceptibility of the viridans group streptococci to β-lactam , macrolide , and fluoroquinolone antibiotic agents? | {
"contexts": [
"Previous work has indicated that environmental stresses on bacteria might lead to an upregulation of stress response. LED curing lights (315-400 nm) and other UV lights used in tooth whitening cosmetic procedures might act as stresses. We examined the effect of UV-C light, as a high-energy surrog... | Exposure to UV-C light will not result in altered antibiotic susceptibility patterns on viridans group streptococci. Given that UV-C is more toxic and mutagenic than UV-A light, it is unlikely than UV-A light would yield any difference in response to such exposure. | no |
22,892,410 | Does prevalence of invalid computerized baseline neurocognitive test result in high school and collegiate athletes? | {
"contexts": [
"Limited data are available regarding the prevalence and nature of invalid computerized baseline neurocognitive test data.",
"To identify the prevalence of invalid baselines on the desktop and online versions of ImPACT and to document the utility of correcting for left-right (L-R) confusion o... | The online ImPACT version appeared to yield fewer invalid baseline results than did the desktop version. Identification of L-R confusion reduces the prevalence of invalid baselines (desktop only) and the potency of Impulse Control as a validity indicator. We advise test administrators to be vigilant in identifying inv... | yes |
22,885,837 | Is downregulation of microRNA-124 an independent prognostic factor in patients with colorectal cancer? | {
"contexts": [
"Recently, microRNA-124 (miR-124) has been demonstrated as a potential tumor suppressor in several types of cancers. However, the role of miR-124 in colorectal cancer remains unclear. This study was aimed at investigating the clinicopathological significance of miR-124 expression in colorectal can... | MiR-124 may play a certain role in the development of colorectal cancer. The downregulation expression of miR-124 is an independent prognostic factor in patients with colorectal cancer. | yes |
22,897,151 | Does expression of Eps8 correlate with poor survival in oral squamous cell carcinoma? | {
"contexts": [
"Epidermal growth factor receptor pathway substrate 8 (Eps8) is a signaling protein implicated in the development of many human cancers including oral squamous cell carcinoma (OSCC). This study examined the expression of Eps8 and assessed its significance in patients with OSCC.",
"Immunohistoc... | Eps8 is frequently expressed in OSCC. The aberrant expression of Eps8 closely correlated with poor survival in patients with OSCC. | yes |
22,895,141 | Is folylpoly-glutamate synthetase expression associated with tumor response and outcome from pemetrexed-based chemotherapy in malignant pleural mesothelioma? | {
"contexts": [
"Pemetrexed-based chemotherapy represents the standard of care in first-line treatment of advanced malignant pleural mesothelioma (MPM). However, there are no established predictors of clinical benefit. Pemetrexed inhibits multiple enzymes involved in pyrimidine and purine synthesis, but the main ... | FPGS and TS expressions were associated with clinical response and outcome to pemetrexed-based first-line chemotherapy in MPM. Prospective evaluation of FPGS and TS expressions and their prognostic/predictive power in MPM patients is warranted. | yes |
22,890,649 | Do systemic interleukin-6 levels reflect illness course and prognosis of patients with spontaneous nonaneurysmal subarachnoid hemorrhage? | {
"contexts": [
"Patients with nonaneurysmal -subarachnoid hemorrhage (SAH) show either perimesencephal (pm)SAH or nonperimesencephalic (non-pm)SAH, with hemorrhage extending into adjacent cisterns. Patients with non-pmSAH have higher risk for a complicated clinical course with cerebral vasospasm (CVS) and worse ... | Higher IL-6 levels in patients with non-pmSAH supports the common observation of more complicated illness course with higher incidence of CVS compared to patients with pmSAH. | yes |
22,882,958 | Do myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients? | {
"contexts": [
"Various human cardiovascular pathophysiological conditions associate aberrant expression of microRNAs (miRNAs) and circulating miRNAs are emerging as promising biomarkers. In mice, myocardial miR-21 overexpression is related to cardiac fibrosis elicited by pressure overload. This study was design... | Our results support the role of miR-21 as a regulator of the fibrotic process that occurs in response to pressure overload in AS patients and underscore the value of circulating miR-21 as a biomarker for myocardial fibrosis. | yes |
22,910,287 | Does dose sparing intradermal trivalent influenza ( 2010/2011 ) vaccination overcome reduced immunogenicity of the 2009 H1N1 strain? | {
"contexts": [
"We hypothesized that low dose intradermal vaccination of the trivalent influenza vaccine (TIV) delivered by the MicronJet600™ (NanoPass Technologies, Israel) would be non-inferior to the full dose intramuscular and mid dose Intanza(®) vaccination in the elderly and the chronically ill adults.",
... | Dose-sparing ID TIV can overcome reduced immunogenicity of the H1N1 strain, and according to some measures, for the H3N2 strain. At risk subjects indicated for the TIV should be considered for intradermal immunization to compensate for reduced immunogenicity. | yes |
22,883,599 | Do extracellular polysaccharides produced by Ganoderma formosanum stimulate macrophage activation via multiple pattern-recognition receptors? | {
"contexts": [
"The fungus of Ganoderma is a traditional medicine in Asia with a variety of pharmacological functions including anti-cancer activities. We have purified an extracellular heteropolysaccharide fraction, PS-F2, from the submerged mycelia culture of G. formosanum and shown that PS-F2 exhibits immunos... | Our results indicate that the extracellular polysaccharides produced by G. formosanum stimulate macrophages via the engagement of multiple pattern-recognition receptors including Dectin-1, CR3 and TLR4, resulting in the activation of Syk, JNK, p38, ERK, and NK-κB and the production of TNF-α. | yes |
22,889,420 | Are for patients with breast cancer , geographic and social disparities independent determinants of access to specialized surgeons . A eleven-year population-based multilevel analysis? | {
"contexts": [
"It has been shown in several studies that survival in cancer patients who were operated on by a high-volume surgeon was better. Why then do all patients not benefit from treatment by these experienced surgeons? The aim of our work was to study the hypothesis that in breast cancer, geographical is... | A disadvantageous socio-economic environment, a rural lifestyle and living far from large specialized treatment centres were significant independent predictors of not gaining access to surgeons specialized in breast cancer. Not being treated by a specialist surgeon implies a less favourable outcome in terms of survival... | yes |
22,909,169 | Are the major royal jelly proteins 8 and 9 ( Api m 11 ) glycosylated components of Apis mellifera venom with allergenic potential beyond carbohydrate-based reactivity? | {
"contexts": [
"As hymenoptera venoms are one of the allergen sources causing the highest incidence of anaphylaxis and sometimes fatal consequences, the detailed characterization of all venom allergens is imperative for design of component-resolved diagnostic approaches and improved intervention strategies.",
... | The glycosylated MRJP8 and MRJP9 of HBV have IgE-sensitizing potential in HBV-allergic patients beyond CCD reactivity and have to be considered as allergens, which might be potentially important for a fraction of venom allergic patients. They are valuable tools to elucidate individual component-resolved reactivity prof... | yes |
22,909,166 | Does iL-17 eliminate therapeutic effects of oral tolerance in murine airway allergic inflammation? | {
"contexts": [
"Oral tolerance is a classically used strategy for antigen-specific systemic immunotherapy. However, the roles of IL-17 in modification of oral tolerance are not yet understood.",
"To define the effects of IL-17 on the modification of oral tolerance, the effects of transfer of Th17 cells, admi... | These data suggest that IL-17 may inhibit the induction of tolerance to antigen through, at least in part augmenting IL-6 production, thereby suppressing the expansion of Treg cells. | yes |
22,886,152 | Are aBCB1 polymorphisms associated with cyclosporine-induced nephrotoxicity and gingival hyperplasia in renal transplant recipients? | {
"contexts": [
"There is a great deal of controversy regarding the clinical impact of genetic variants in patients receiving cyclosporine (CsA) as immunosuppressant therapy. We have investigated the effect of polymorphisms in the CYP3A and ABCB1 genes on CsA pharmacokinetics, acute rejection incidence and drug-r... | ABCB1 polymorphisms may be helpful in predicting certain CsA-related side effects in renal transplant recipients. Our results also suggest that the mechanisms underlying these genetic associations are most likely independent of the drug's trough blood concentrations. | yes |
22,883,657 | Do deep inspiration breath hold technique reduces heart dose from radiotherapy for left-sided breast cancer? | {
"contexts": [
"Adjuvant left breast radiotherapy (ALBR) for breast cancer can result in significant radiation dose to the heart. Current evidence suggests a dose-response relationship between the risk of cardiac morbidity and radiation dose to cardiac volumes. This study explores the potential benefit of utilis... | DIBH resulted in a significant reduction in radiation dose to the heart and LAD compared with an FB technique for ALBR. Ongoing research is required to determine optimal cardiac dose constraints and methods of predicting which patients will derive the most benefit from a DIBH technique. | yes |
22,879,454 | Does the severity of urinary incontinence decrease health-related quality of life among community-dwelling elderly? | {
"contexts": [
"Urinary incontinence (UI) is an important geriatric syndrome that has been associated with a wide range of health-related outcomes. However, UI severity has rarely been examined in the context of a comprehensive geriatric assessment. Therefore, the aim of this study is to examine the association ... | UI severity is associated with lower QoL scores in both its components. This association appears to be more important as severity increases. UI severity must be evaluated thoroughly in the elderly because of its potential adverse effects on physical and mental health. | yes |
22,898,900 | Is promotion of liver regeneration by natural killer cells in a murine model dependent on extracellular adenosine triphosphate phosphohydrolysis? | {
"contexts": [
"Nucleotides, such as adenosine triphosphate (ATP), are released by cellular injury, bind to purinergic receptors expressed on hepatic parenchymal and nonparenchymal cells, and modulate cellular crosstalk. Liver resection and resulting cellular stress initiate such purinergic signaling responses b... | We propose that hepatic NK cells are activated and cytotoxic post-PH and support hepatocellular proliferation. NK cell cytotoxicity is, however, attenuated by hepatic release of extracellular ATP by way of the activation of specific P2 receptors. Clearance of extracellular ATP elevates NK cell cytotoxicity and boosts l... | yes |
22,898,909 | Is homoharringtonine an effective therapy for patients with polycythemia vera or essential thrombocythemia who have failed or were intolerant to hydroxycarbamide or interferon-α therapy? | {
"contexts": [
"At present, the treatment of polycythemia vera (PV) and essential thrombocythemia (ET) is still largely supportive and symptomatic. Homoharringtonine (HHT), a valid drug for treating chronic myelogenous leukemia, has shown some effect on leukemic stem cells. The aim of this study was to observe t... | Low-dose HHT alone has considerable short-term efficacy for high-risk PV/ET and may used as a second-line drug for PV/ET treatment in patients who have failed or were intolerant to hydroxycarbamide or interferon-α therapy. | yes |
22,900,609 | Does transcriptome-based exon capture enable highly cost-effective comparative genomic data collection at moderate evolutionary scales? | {
"contexts": [
"To date, exon capture has largely been restricted to species with fully sequenced genomes, which has precluded its application to lineages that lack high quality genomic resources. We developed a novel strategy for designing array-based exon capture in chipmunks (Tamias) based on de novo transcri... | Our study demonstrates the potential of a transcriptome-enabled, multiplexed, exon capture method to create thousands of informative markers for population genomic and phylogenetic studies in non-model species across the tree of life. | yes |
22,907,597 | Is a dose-escalation regimen of trimethoprim-sulfamethoxazole tolerable for prophylaxis against Pneumocystis jiroveci pneumonia in rheumatic diseases? | {
"contexts": [
"To investigate the safety and efficacy of a dose-escalation regimen of trimethoprim-sulfamethoxazole (TMP/SMX) for prophylaxis against Pneumocystis jiroveci pneumonia (PCP) in rheumatic diseases.",
"Data from 41 patients, who received glucocorticoids with or without immunosuppressive agents a... | In rheumatic diseases, a dose-escalation regimen of TMP/SMX resulted in a higher retention rate and was safer than the routine regimen. | yes |
22,903,146 | Is 17β Hydroxysteroid dehydrogenase type 12 ( HSD17B12 ) a marker of poor prognosis in ovarian carcinoma? | {
"contexts": [
"17β-hydroxysteroid dehydrogenase isoform 12 (HSD17B12) overexpression is associated with poor clinical outcome in invasive ductal carcinoma of the breast. Here, we evaluated HSD17B12 overexpression and its activity in ovarian carcinoma (OvCa) to determine its role in the growth and progression of... | HSD17B12 overexpression is shown to be a marker of poor survival in patients with OvCa. Expression in the tumor and function of this enzyme facilitates OvCa progression. | yes |
22,903,136 | Does acute severe exercise facilitate neutrophil extracellular trap formation in sedentary but not active subjects? | {
"contexts": [
"Neutrophil extracellular trap (NET), a newly revealed antimicrobial strategy, is usually evoked by reactive oxygen species (ROS) and nicotinamide adenine denucleotide phosphate (NADPH) oxidase activation. In addition, the acute severe exercise (ASE)-induced oxidative stress in neutrophils depends... | ASE in sedentary but not active subjects facilitated NET formation via elevating the NADPH oxidase-generated ROS and suppressing the ΔΨm. | yes |
22,908,361 | Does a replication study of a GWAS finding in migraine identify association in a Spanish case-control sample? | {
"contexts": [
"Migraine is a prevalent neurological disorder with a complex genetic background characterized by recurrent episodes of headache. The disease is subclassified into migraine with aura (MA) and migraine without aura (MO). Many association studies have been performed to date to identify genetic risk ... | No association was found between the assayed SNP and any of the clinical groups considered. | no |
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