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Due to ethical restrictions, data will be available upon request to Dr. Violet Naanyu (<vnaanyu@mu.ac.ke> or <vnaanyu@gmail.com>) pending ethical approval from the local institutional research board and the AMPATH program.
Introduction {#sec001}
============
High healthcare costs, a lack of adequate infrastructure, a... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Addressing stress during pregnancy and the postpartum period is important as these periods are physically, psychologically and socially distinct periods in a women\'s lifetime during which mothers experience concerns about the health of their child, their own health, changes in their bodies and t... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Dental caries, a multi-factors related disease, is a major factor of irreversible tooth decay and will in further lead to pulpitis, severe toothache, and chronic infections^[@CR1]^. The etiology and related risk factors of dental caries have been a hot topic for a long period of time.... | {
"pile_set_name": "PubMed Central"
} |
Plant--pollinator interactions are essential for both actors and are an important ecosystem service for natural and agricultural systems ([@bib59]; [@bib120]). However, climate change may put this critical interaction at risk ([@bib42]; [@bib101]). For example, the spring ephemeral *Corydalis* *ambigua* Cham. & Schltdl... | {
"pile_set_name": "PubMed Central"
} |
###### Strengths and limitations of this study
- We address a dearth of evidence on socioeconomic differences in terms of prescribed and over-the-counter (non-prescribed) medication usage (disaggregated by medicine type) using a large secondary data set.
- Our data are self-reported and may be subject to bias sug... | {
"pile_set_name": "PubMed Central"
} |
The antimetabolite pentyl pantothenamide **1** \[N5-Pan ([Scheme [1](#sch1){ref-type="scheme"}](#sch1){ref-type="scheme"}a)\] was first described in 1970.^[@ref1]^ Like other pantothenamides, it has broad spectrum antibiotic activity but, uniquely, shows an order of magnitude improvement against *Escherichia coli*, wit... | {
"pile_set_name": "PubMed Central"
} |
Related literature {#sec1}
==================
For related literature on the biological and non-linear optical properties of chalcone derivatives, see: Agrinskaya *et al.* (1999[@bb1]); Chopra *et al.* (2007[@bb5]); Patil *et al.* (2006[@bb8]); Patil, Ng *et al.* (2007[@bb7]); Patil, Fun *et al.* (2007[@bb6]). For bond... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
A central goal of genetics is the identification of genotype-phenotype associations. Traditional quantitative trait loci (QTL) mapping and genome-wide association studies (GWAS) are the primary tools for achieving such a goal. Thousands of genetic variants associated with traits of agro... | {
"pile_set_name": "PubMed Central"
} |
**Specifications Table**TableSubject area*Biology; Biomaterials*More specific subject area*An inducible three-dimensional in vitro culture system for recapitulating tumor satellite formation of cancer*Type of data*Figures and Charts*How data was acquired*An in vitro three-dimensional collagen culture system was establi... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Autophagy (from the Greek, *autos*, which means "self", and *phagein*, "to eat") is an evolutionarily conserved catabolic pathway, which delivers cytoplasmic constituents such as proteins and organelles to the lysosome for degradation and recycling \[[@CR1]--[@CR3]\]. Autophagy regula... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
In recent years, it has been observed that oncological treatment has become increasingly successful, which is reflected in the prolonged life expectancy of patients. The side effects of oncological therapies which appear during or after treatment seem not to be a problem that doctors ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
People who inject drugs (PWID) account for more than half of all people infected with HIV in Vietnam \[[@CR1], [@CR2]\]. The HIV prevalence among those who inject drugs is estimated to be 33% and ranges from 3 to 58% in different provinces \[[@CR3]\]. Methadone maintenance therapy (MMT) b... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#Sec1}
============
In the recent years, the adsorption of lipid drug formulations onto porous solid carriers has been the aim of several studies ([@CR1]--[@CR16]). It is known that in the case of insoluble drugs, an ideal solid carrier should have a high loading capacity, no toxicity, no negative impact... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Skeletal muscle has the remarkable ability to adapt to changes in cellular environmental influences during exercise \[[@B1]\]. Studies have shown that muscle stimulation can induce diverse metabolic and morphological adaptations, which are important mechanisms for controlling sk... | {
"pile_set_name": "PubMed Central"
} |
Alcohol use and misuse have been part of human society for centuries. Early physicians recognized since the 1800s that alcohol produced not only impairment of the senses but also higher predisposition for tuberculosis. William Osler, the father of scientific medicine, reported in 1905 that patients who misused alcohol ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Health behavior change and illness management play a critical role in the treatment for patients with an acute coronary syndrome (ACS) \[[@ref1],[@ref2]\]. However, the short hospitalizations following an ACS leave little time for health professionals to provide tailored information and suppo... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
With over 10.0 million incident cases and more than 1.4 million death in 2018, tuberculosis (TB) remains a major threat to global public health \[[@CR1]\]*.* The burden of drug-resistance is of main interest and concern at global, regional and country levels; emergence of drug-resistance ... | {
"pile_set_name": "PubMed Central"
} |
A 69-year-old woman presented with a 2-year history of recurrent episodes of hemoptysis, one of which was severe, leading to admission to an intensive care unit. She had a history of pulmonary tuberculosis treated 20 years previously. A chest X-ray ([Figures 1](#f1){ref-type="fig"}A and 1B) and chest CT ([Figures 1](#f... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Methadone is a synthetic opioid which was first introduced in Germany between 1937 and 1939. A long half-life of 25 to 52 hours and high analgesic effects, makes methadone suitable for maintenance therapy in opium addicts and is currently used as the basis of withdrawal management as methadon... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijms-20-03560}
===============
Elastin-Like polypeptides (ELPs) are a class of stimuli-responsive biopolymers \[[@B1-ijms-20-03560],[@B2-ijms-20-03560]\], which show an inverse phase transition temperature (Tt) \[[@B3-ijms-20-03560],[@B4-ijms-20-03560],[@B5-ijms-20-03560]\]~.~ They have been use... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Abl interactor (Abi) family proteins are known to be involved in regulation of the actin cytoskeleton. Mammals possess three Abi proteins (Abi-1, Abi-2, and NESH/Abi-3). The Abi-1 and Abi-2 proteins were first identified on yeast two-hybrid screening for proteins that interact with a non-... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The term \"educational environment\" indicates all factors that affect the process of students\' learning, such as the physical location, teachers, colleagues, and culture. It is defined as everything that happens within the classroom, department, faculty or university that is essential in de... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1-1}
============
Lead poisoning is one of the compensable diseases in India since 1924.\[[@CIT1]\] However, reliable statistics and scientific data regarding occurrence of occupational lead poisoning are not available with the respective departments.
One hundred and ninety-five workers working in s... | {
"pile_set_name": "PubMed Central"
} |
For early detection and optimized management of thyroid dysfunction before and during pregnancy, we have to look at four levels of prevention: primordial, primary, secondary, and tertiary. There are new insights into this concept, which greatly enhance the health promotion of pregnant women
**Primordial and Primary Pr... | {
"pile_set_name": "PubMed Central"
} |
In August 2010 an iceberg four times the size of Manhattan broke off Greenland's northwestern coast and began drifting out to the sea. At nearly 100 square miles, this was the largest iceberg to appear in Arctic waters since 1962 and a fresh indicator that Greenland's frozen landscape is undergoing significant changes.... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Lung cancer has been the leading cause of cancer-associated mortality worldwide in males (24%) and females (23%) in 2019 ([@b1-ol-0-0-10302]). Non-small cell lung cancer (NSCLC) accounts for 85% of all types of lung cancer ([@b2-ol-0-0-10302]). Platinum-based chemotherapy is the standard trea... | {
"pile_set_name": "PubMed Central"
} |
[^1]: Academic Editor: Martin Goette
| {
"pile_set_name": "PubMed Central"
} |
Introduction {#S1}
============
Surgery combined with radiotherapy, chemotherapy or both is the gold standard treatment for head and neck cancers. Surgery aims to remove all disease. However, this often results in functional and aesthetic impairment, so immediate reconstruction using local, regional or free flaps, is ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-ijerph-14-00920}
===============
Ultraviolet radiation from the sun causes a considerable global disease burden, including acute and chronic health effects on the skin, the eyes and the immune system \[[@B1-ijerph-14-00920]\]. Negative effects of an increased UV exposure include, for example, er... | {
"pile_set_name": "PubMed Central"
} |
Epigenetic therapies have gained interest amongst the community of scientists and clinicians. Most notably, Histone deacetylase inhibitors (HDACi) and BET bromodomain protein inhibitors (BRD4i) are key players in this field, such as OTX015. Pan-HDACi, such as panobinostat or vorinostat, have received FDA-approval for c... | {
"pile_set_name": "PubMed Central"
} |
Correction to: Clin Sarcoma Res (2019) 9:4 10.1186/s13569-019-0114-5 {#Sec1}
====================================================================
The legends for Figs. 3 and 5 of the article \[[@CR1]\] incorrectly refer to an "all others group". The corrected legends should read:
**Fig.** **3** Exploratory analyses o... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Functional near-infrared spectroscopy (fNIRS), a promising noninvasive imaging technique, has become an increasingly popular neuroimaging technique for brain function research in recent years \[[@B1]--[@B4]\]. This technique holds several advantages relative to functional magnet... | {
"pile_set_name": "PubMed Central"
} |
{#F1}
{#F2}
**Helping all children who need spectacles means doing more than visiting schools and offering good refractive services. Partnerships with local government, hospitals and community groups are needed, alongside a thorough ... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
More than ten million children under five years die every year \[[@B1]\]. Most of these deaths are in developing countries and roughly two-thirds could be prevented by interventions that are already available. The leading causes of these deaths are malaria, pneumonia, respiratory infections and d... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Osteoporosis is the most common metabolic bone disease and affects more than 200 million individuals worldwide ([@B1]); in Spain alone it affects more than 3 million individuals. As a result, there has been a progressive increase in recent years in the prescription of drugs to combat the dise... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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{
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I[NTRODUCTION]{.smallcaps} {#sec1-1}
==========================
Postoperative pain delays discharge after operations and increase postoperative cost. Several methods were tried before to decrease this pain after arthroscopic knee surgery as opioids, nonopioid drugs, central, peripheral nerve blocks, and intra-articula... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-molecules-20-18219}
===============
The skin, the largest organ of the body, forms an effective barrier between the organism and the outer environment preventing pathogens invasion and fending off chemical and physical assaults \[[@B1-molecules-20-18219]\]. It is also the most easily accessible ... | {
"pile_set_name": "PubMed Central"
} |
Asian Citizen's Center for Environment and Health is an environmental non-governmental organization that specializes in the Environment and Public Health sector. On December 21, at the 2015 Citizen's Awards for Environment and Public Health, they awarded the Citizen's Award to 3 members of the UK overseas protest group... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1-1}
============
The renin angiotensin system (RAS) is one of the most studied physiological systems in humans. It is well known as major actor in the regulation of cardiovascular homeostasis, maintaining electrolyte balance, body fluid volume, and arterial pressure, through the production of aldost... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
The majority of terpenoid indole alkaloids (TIAs) are confined to the dicotyledons occurring most frequently in Apocynaceae and to a lesser extent in Loganiaceae and Rubiaceae families.^[@R1]^ *Catharanthus roseus* (L.), a member of Apocynaceae family, produces more than 130 monoterpeno... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
The essence of health insurance is to mobilise healthcare resources from citizens through a prepayment system and to protect individuals and households from catastrophic health expenditures, in order to enhance population coverage with quality health services.
Although, health insurance ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-animals-10-00254}
===============
Recognition of the value of animal companionship for human health is growing \[[@B1-animals-10-00254],[@B2-animals-10-00254]\]. The numbers and roles of service dogs are expanding globally \[[@B3-animals-10-00254]\]. According to US legislation, a "service dog" ... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Nonlinear regression, like linear regression, assumes that the scatter of data around the ideal curve follows a Gaussian or normal distribution. This assumption leads to the familiar goal of regression: to minimize the sum of the squares of the vertical or Y-value distances between the points and... | {
"pile_set_name": "PubMed Central"
} |
**Conflicts of interest:** AGJvdZ, ES, and GBAW are inventors of patents related to the content of our study. ES is a member of the scientific advisory board of Roche, Hologic and QCMD, and received travel reimbursements from Roche, Abbott, Hologic Inc. and QCMD. GBAW is a member of the scientific advisory board of CC ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
The possible experimental realisation of a supersolid state of matter in bulk solid $\documentclass[12pt]{minimal}
\usepackage{amsmath}
\usepackage{wasysym}
\usepackage{amsfonts}
\usepackage{amssymb}
\u... | {
"pile_set_name": "PubMed Central"
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1. Introduction
===============
Epithelial ovarian cancer (EOC) is responsible for 4% of cancer-deaths in women and continues to be the leading cause of death from gynecologic malignancies in the United States \[[@B1-cancers-05-01163]\]. The incidence of ovarian cancer in postmenopausal women is 5--6 times greater, an... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-biology-09-00163}
===============
*Matthiola incana* (L.) R. Br. (Brassicaceae), usually called "stock flower", is widely cultivated for ornamental purposes in many regions around the world \[[@B1-biology-09-00163],[@B2-biology-09-00163]\].
This species is utilized in the traditional medicine o... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper.
Introduction {#sec005}
============
Alcoholic liver disease (ALD) affects more than 2.5 million people in U.S \[[@pone.0163342.ref001],[@pone.0163342.ref002]\]. The pathological changes of human ALD are characterized in three major categories: steatosis, hepatitis, and fibrosis... | {
"pile_set_name": "PubMed Central"
} |
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"pile_set_name": "PubMed Central"
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The US Food and Drug Administration (FDA) issued an indication for olanzapine in the treatment of adolescents, 13--17 years old, with schizophrenia or acute manic/mixed episodes in bipolar I disorder (BPI) in December 2009. However, the FDA also formally stated that clinicians may "consider prescribing other drugs firs... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Non-resolving persistent inflammation contributes to wound chronicity^[@CR1],[@CR2]^. Inflammation is required to set the process of wound healing in motion^[@CR3]^. However, it is important to resolve such inflammation in a timely manner to achieve healing^[@CR4]^. Wound inflammation... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Heat stress caused by high ambient temperature and relative humidity is one of the most severe issues in commercial poultry production due to its serious damage on performance, immunity and antioxidant status of broilers \[[@b1-ajas-19-0274]\], gene expression \[[@b2-ajas-19-0274]\], and body... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Recombination between two homologous chromosomes during meiosis generates novel gene combinations and creates genetic diversity among chromosomes. Furthermore, recombination is critical for proper segregation of homologous chromosomes, and is a major factor shaping linkage disequilibrium (LD) pat... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#s1}
===============
Recent advances in next-generation sequencing technologies have enabled the collection of sequence information from many genomes and exomes, with many large human and cancer genetic studies measuring mutations in all genes for a large number of patients of a specific disease (Canc... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION {#sec1}
============
Excitation-contraction coupling (ECC) in cardiac myocytes is initiated by the action potential, which activates sarcolemmal L-type Ca^2+^ channels (LTCCs), causing Ca^2+^ influx \[Ca^2+^ current (*I*~Ca~)\]. *I*~Ca~ triggers Ca^2+^ release from adjacent sarcoplasmic reticulum (SR) via... | {
"pile_set_name": "PubMed Central"
} |
Leerdoelen {#FPar1}
==========
Verwerven van kennis en inzicht in de effecten van maternale aandoeningen en infecties op de ontwikkeling van de foetus en het verloop van de zwangerschap.
Verwerven van kennis en inzicht in de effecten van zwangerschap op het verloop van maternale aandoeningen en infecties.
Definities... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Esophageal carcinoma, one of the most aggressive carcinomas of the gastrointestinal tract, is the eighth most common cause of cancer-related death worldwide [@pone.0063581-Kamangar1], [@pone.0063581-Parkin1]. The two main subtypes of esophageal carcinoma are adenocarcinoma and squamous ... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Traditionally, rhinitis is divided into two types according to its etiology; allergic rhinitis (AR) and nonallergic rhinitis (NAR). Nowadays, most epidemiologic studies of AR are based on mostly self-reported prevalence of symptoms and often lack objective measures. Moreover, epidemiologi... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Periodontitis is an inflammation of hard and soft tissues around the teeth that leads to progressive destruction of the alveolar bone and the fibrous apparatus \[[@CR1]\]. Microorganisms located in subgingival biofilm are generally accepted as the main etiologic factor for periodontitis \... | {
"pile_set_name": "PubMed Central"
} |
According to DSM IV (Diagnostic and Statistical Manual of Mental Disorders 4th edition -- text revision \[[@B1]\] Reactive Attachment Disorder (RAD) describes the clinical condition wherein children, as a consequence of pathogenic care, fail to seek proximity with a preferred caregiver and are unable to form an attachm... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1}
===============
Duodenal perforation in children is a rare surgical emergency often missed or not considered commonly in the differential diagnoses of acute abdomen \[[@B1], [@B2]\]. Peptic ulcer disease (PUD) in children is reported worldwide with an estimated frequency of 8.1% in Europe and 1... | {
"pile_set_name": "PubMed Central"
} |
Restriction--modification (RM) systems confer selective advantage to bacterial and archaeal cells, principally by protecting their hosts from infection by foreign DNA elements such as bacteriophages or plasmids. For the RM systems classified as Types I, II and III, the distinction between foreign and self occurs at the... | {
"pile_set_name": "PubMed Central"
} |
Cattle are infected by retroviruses from three genera: *deltaretrovirus*, *lentivirus*, and *bovispumavirus* \[[@r1], [@r14]\]. Bovine leukemia virus (BLV) is a *deltaretrovirus*, the pathogenesis and epidemiology of which has been well characterized \[[@r11], [@r20]\]. However, as with other retroviral infections amon... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Low back pain (LBP) is known to have a fluctuating course \[[@B1]\] at least in some groups of patients \[[@B2],[@B3]\]. People with LBP probably seek care when their symptoms are at a peak, and during the ensuing time some will improve, either because of or regardless of the treatment. In clinic... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Lung cancer has been one of the most common causes of cancer-related death in the world^[@CR1]^, and its incidence and mortality rates are also much higher than other cancer in China^[@CR2]^. It consists of two different histological types, non-small-cell lung carcinoma (NSCLC) and sm... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
In this penicillin era, *Streptococcus pneumoniae* is still the most frequent microbial agent of community acquired bacterial meningitis in adults with high mortality.[@B1] Also pneumococcal endocarditis (PE) responsible for less than 3% of all cases of endocarditis in native valve have aggre... | {
"pile_set_name": "PubMed Central"
} |
In type 1 diabetes, the immune system attacks and destroys β cells. At the clinical onset of type 1 diabetes, 15--40% of β cells are still able to produce insulin, thus blocking further autoimmune destruction even at this stage, holding great promise for arresting disease progression ([@B1]). Yet earlier intervention i... | {
"pile_set_name": "PubMed Central"
} |
Editor: Jean-Marc Rolain
1. Global epidemiology of coronavirus disease 2019 (COVID-19) {#sec0001}
=============================================================
Since the first reported case of COVID-19 in Wuhan, China, at the end of 2019, COVID-19 has rapidly spread throughout China and has also involved many other c... | {
"pile_set_name": "PubMed Central"
} |
The novel coronavirus disease (COVID-19) was declared a pandemic by the World Health Organization (WHO) on March 11, 2020 (World Health Organization, 2020b). Since its identification in a wet market in Wuhan, China, in December 2019 ([@bib0120]), to this date (May 14^th^, 2020), there has been a total of 4,248,389 conf... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
In the context of mate selection by female songbirds, male suitors seek to attract female mates through their song performances and other signals such as plumage or reproductive displays. Females detect those signals and use that sensory information to form a subjective evaluation of th... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
The field of DNA nanotechnology has enjoyed extraordinary success in constructing structures with ever increasing complexity, as defined by the number of addressable components^[@CR1]--[@CR4]^. Two methods have stood out: the scaffolded origami approach of folding a long scaffold with... | {
"pile_set_name": "PubMed Central"
} |
ERRATUM {#h0.0}
=======
Volume 5, no. 3, doi: 10.1128/mBio.01125-14, 2014.
In the Results and Discussion section (PDF page 3, line 11), TCA should have been introduced as an abbreviation for tricarboxylic acid, not trichloroacetic acid.
In the Supplemental Material, for Table S1B (Fisher Exact Test in Stationary Pha... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
The current standard of care for neovascular age-related macular degeneration (nAMD) involves repeated intravitreal injections of an anti-VEGF drug. Both ranibizumab[@b1-opth-12-593],[@b2-opth-12-593] and aflibercept[@b3-opth-12-593] have shown good efficacy in the improvement of visual acuit... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Takotsubo cardiomyopathy is characterized by transient left ventricular (LV) regional wall motion abnormalities and usually involves apical segments in the absence of significant coronary artery stenosis. In the recent years, several cases on atypical forms of transient LV ballooning syndrome... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#s1}
============
Human-based computer modelling and simulation are a fundamental asset of biomedical research. They augment experimental and clinical research through enabling detailed mechanistic and systematic investigations. Owing to a large body of research across biomedicine, their credibility has ... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Currently, it is possible to observe the activity (over-, under- expression, presence or absence of mutations) of almost all molecules of a given type (mRNA, miRNA, DNA) in a single screen using high-density chips \[[@B1]\], or sequencing related techniques \[[@B2],[@B3]\]. Lately, the number of ... | {
"pile_set_name": "PubMed Central"
} |
Introduction
============
Lipid nanocapsules (LNCs) are nanometric vectors that can be used to dissolve lipophilic drugs without the need of organic solvents or excipients known to have a recognized effect.[@b1-ijn-12-8159] They are versatile nano-sized drug carriers able to solubilize highly lipophilic drugs and to g... | {
"pile_set_name": "PubMed Central"
} |
**A**n 85-year-old man was referred to the Otolaryngology-Head and Neck Surgery clinic in February 2013 for left ear pain associated with a small lesion with intermittent bleeding. He had no other systemic or neurologic symptoms. This was believed to be chondrodermatitis nodularis chronica helicis. One year later, the ... | {
"pile_set_name": "PubMed Central"
} |
Background
==========
Young men in Australia have poorer mental health than their female counterparts including higher rates of completed suicide, antisocial behaviour, and alcohol and substance misuse problems \[[@B1]\]. Although gender differences in help-seeking vary according to type of problem and source of help ... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Bacteria engage in altruistic cooperation by secreting a variety of costly molecules which modify the environment to the benefit of the bacterial community. Such public goods molecules include enzymes, toxins, antibiotics, and surfactants \[[@CR1]--[@CR3]\]. Public goods secretion is ... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Endoscopic retrograde cholangiopancreaticography (ERCP) allows for visualization of pancreatic duct (PD) and bile duct. It is the confirmative tool for diagnosis and treatment of disorders of PD and bile duct, even though magnetic resonance cholangiopancreaticography has emerged as an alterna... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#Sec1}
============
Low birth weight (LBW, \<2500 g) is a most important factor of neonatal mortality and a major determinant of postnatal infant mortality, as well as morbidity in infancy and in older childhood^[@CR1]^. Studies have shown that LBW infants die 40 times as much as normal weight infants, a... | {
"pile_set_name": "PubMed Central"
} |
Treatment of hyperglycemia in patients with type 2 diabetes remains a challenge, particularly in those who require insulin as the disease progresses ([@B1],[@B2]). Various combinations of insulin with oral antidiabetic agents (OADs) have been investigated ([@B2][@B3][@B4][@B5][@B6][@B7]--[@B8]). Often, these combinatio... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-sensors-17-01881}
===============
Wireless sensor networks are composed of a large number of sensor nodes distributed randomly in a particular area, which can be used for sensing data, information transmission, event monitoring and so on. However, most nodes in the network are powered by batteri... | {
"pile_set_name": "PubMed Central"
} |
Emerging evidence indicates that the tumour microenvironment plays a vital role in the initiation and progression of many cancers[@b1]. In breast cancer, cancer-associated fibroblasts and tumour-associated macrophages promote breast cancer progression and metastasis by secreting growth factors and chemokines[@b2][@b3][... | {
"pile_set_name": "PubMed Central"
} |
Introduction {#sec1}
============
Pyoderma gangrenosum (PG) is an idiopathic, ulcerating neutrophilic dermatosis.[@bib1] We present a patient with 12 years of peristomal PG recalcitrant to numerous steroids and immunosuppressants who attained complete remission after iron sucrose infusion.
Case report {#sec2}
=======... | {
"pile_set_name": "PubMed Central"
} |
The eukaryotic translation initiation factor 4E (eIF4E) has key roles in carcinogenesis ([De Benedetti and Graff, 2004](#bib9){ref-type="other"}). eIF4E is often overexpressed in carcinoma cells as compared to equivalent normal epithelium in many tumour types including breast ([Kerekatte *et al*, 1995](#bib17){ref-type... | {
"pile_set_name": "PubMed Central"
} |
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Background {#Sec1}
==========
Health workforce has a crucial position in healthcare as it serves as a vehicle for change to ensure quality health services. Accounting for more than 60% of the cost of providing inpatient care \[[@CR1]\], the health workforce is also crucial for the sustainability of any healthcare syst... | {
"pile_set_name": "PubMed Central"
} |
All relevant data are within the paper and its Supporting Information files.
Introduction {#sec001}
============
Site-specific recombinases constitute a distinctive class of enzymes that possess the unique ability to both cleave and reseal DNA. Some of these recombinases function without cofactors and lead to precise... | {
"pile_set_name": "PubMed Central"
} |
INTRODUCTION
============
Hepatocellular carcinoma (HCC) is a serious health problem and has a poor prognosis. HCC accounts for 5.6% of all human cancers with more than 1 million deaths annually and the incidence of HCC is increasing.[@B1],[@B2] Despite the implementation of surveillance programs for early HCC, most t... | {
"pile_set_name": "PubMed Central"
} |
The affiliation for the fourth author is incorrect. Ruoling Chen is not affiliated with \#3 but with \#4 Centre for Health and Social Care Improvement (CHSCI), University of Wolverhampton, Wolverhampton, United Kingdom.
| {
"pile_set_name": "PubMed Central"
} |
Background
==========
COPD is a chronic and debilitating disease and a leading cause of morbidity and mortality worldwide \[[@B1]\]. According to the latest estimates of the World Health Organization (WHO), 210 million people have COPD and 3 million people died of COPD in 2005 \[[@B2]\]. Improving patients\' health st... | {
"pile_set_name": "PubMed Central"
} |
In addition to metallic graphene and semiconducting transition metal dichalcogenides, hexagonal boron nitride (h-BN) is an insulating two-dimensional (2D) material, in which all these materials serve as primary components for soft electronics with high flexibility and transmittance[@b1][@b2]. Since all the atoms in 2D ... | {
"pile_set_name": "PubMed Central"
} |
1. Introduction {#sec1-polymers-11-00969}
===============
Water pollution by toxic heavy metal ions (HMs) is a cause of great global concern, because of their toxicity, non-biodegradability, and possible carcinogenicity \[[@B1-polymers-11-00969],[@B2-polymers-11-00969]\]. Thus strict regulations and guidelines for the... | {
"pile_set_name": "PubMed Central"
} |
Background {#Sec1}
==========
Evidence based clinical practice guidelines (CPG) are an efficient strategy to optimize health care through the implementation of valid recommendations for specific conditions. They guide health professionals and decision makers in areas of clinical uncertainty \[[@CR1]--[@CR4]\] through ... | {
"pile_set_name": "PubMed Central"
} |
Key PointsCognitive impairments such as reading disability and speech sound disorder are recognized in both children with BECTS and their siblingsThe BECTS group had decreased functional connectivity relative to controls within key constituents of the language networkA similar decrease was observed for siblings, but th... | {
"pile_set_name": "PubMed Central"
} |
1.. Introduction
================
The DOA (Direction of Arrival) estimation problem arises in many engineering applications, such as smart antennas, mobile communications, radio astronomy, sonar and navigation. There have been many high resolution DOA estimation algorithms; see \[[@b1-sensors-13-11167]\] and the refer... | {
"pile_set_name": "PubMed Central"
} |
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