Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Mitotic rate and subcutaneous involvement are prognostic factors for survival after recurrence in patients with only locoregional skin metastasis as the first site of recurrence from cutaneous melanoma. | BACKGROUND: Few reports on literature give detailed figures on prognostic factors of locoregional skin recurrence in cutaneous melanoma.OBJECTIVE: The aim of this study was to evaluate clinical and histological prognostic factors following development of locoregional cutaneous metastasis as the only progression site fr... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Male', 'Melanoma', 'Middle Aged', 'Mitosis', 'Neoplasm Recurrence, Local', 'Prognosis', 'Skin Neoplasms', 'Survival Rate'] | 22,303,982 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['M01.060.116.630'], ['G04.144.220.220.781', 'G05.113.220.781'], ['C04.697.655', 'C23.550.727.655'], ['E01.789'], ['C04.588.805', 'C... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Steady-state humic-acid-containing blanket in upflow suspended bed. | We investigated the effects of turbidity and concentration of humic acid on the steady-state behavior of the blanket, which was coagulated using polyaluminum chloride (PACl) as coagulant. The three-dimensional solid-flux plot was constructed. Based on fixed PACl dosage, the iso-humic-acid solid-flux surfaces stacked th... | ['Aluminum Chloride', 'Aluminum Compounds', 'Chlorides', 'Coagulants', 'Drinking', 'Flocculation', 'Humic Substances', 'Nephelometry and Turbidimetry', 'Waste Disposal, Fluid', 'Water Movements', 'Water Purification', 'Water Supply'] | 15,743,628 | [['D01.056.031', 'D01.210.450.150.025'], ['D01.056'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D27.505.954.502.270'], ['G07.203.650.283.249', 'G10.261.330.249'], ['E05.196.150.347', 'G02.159.347'], ['D02.241.444', 'D02.455.426.559.389.657.377', 'D20.721.500'], ['E05.196.712.650'], ['N06.850.780.200.800.800.890', '... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Effects of conditioned medium from different cultured cell types on aromatase expression in adipose stromal cells. | OBJECTIVE: To determine whether serum-free (SF) conditioned media (CM) from several human breast cancer cell lines and primary stromal cell cultures contain factor(s) that mimic the marked stimulatory effects of serum on aromatase activity and aromatase P450 (P450arom) gene expression in adipose stromal cells in cultur... | ['Adipose Tissue', 'Aromatase', 'Breast Neoplasms', 'Culture Media, Conditioned', 'Culture Media, Serum-Free', 'DNA Primers', 'Dexamethasone', 'Estradiol', 'Estrogen Antagonists', 'Female', 'Fulvestrant', 'Humans', 'Polymerase Chain Reaction', 'Stromal Cells', 'Tumor Cells, Cultured'] | 9,420,848 | [['A10.165.114'], ['D08.244.453.489.500', 'D08.244.453.915.099', 'D08.811.682.690.708.170.447.500', 'D08.811.682.690.708.170.915.099', 'D12.776.422.220.453.489.500', 'D12.776.422.220.453.915.099'], ['C04.588.180', 'C17.800.090.500'], ['D27.720.470.305.250', 'E07.206.250'], ['D27.720.470.305.255', 'E07.206.255'], ['D13.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical validation of dried blood spot sampling in therapeutic drug monitoring of ciclosporin A in allogeneic stem cell transplant recipients: direct comparison between capillary and venous sampling. | BACKGROUND: The immunosuppressive drug ciclosporin A has a narrow therapeutic window and a large inter- and intraindividual pharmacokinetic variability. Therapeutic drug monitoring of ciclosporin is usually performed in ethylenediaminetetraacetic acid blood, obtained by venous sampling. Dried blood spot sampling (DBS) ... | ['Adolescent', 'Capillaries', 'Cyclosporine', 'Dried Blood Spot Testing', 'Drug Monitoring', 'Edetic Acid', 'Fingers', 'Humans', 'Immunosuppressive Agents', 'Phlebotomy', 'Stem Cell Transplantation', 'Transplantation', 'Transplantation, Homologous', 'Veins'] | 23,296,096 | [['M01.060.057'], ['A07.015.461.165'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['E01.370.225.124.100.232', 'E05.200.124.100.232'], ['E01.370.520.200'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['A01.378.800.667.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E01.370... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania. | Antimonial-containing drugs are the first line of treatment against the parasite Leishmania. Resistance to antimonials has been correlated to its reduced accumulation. We used a dominant negative functional cloning strategy where a Leishmania mexicana expression cosmid bank was transfected in cells resistant to trivale... | ['Amino Acid Sequence', 'Animals', 'Antimony', 'Antiprotozoal Agents', 'Cells, Cultured', 'Drug Resistance', 'Gene Expression Regulation', 'Leishmania', 'Molecular Sequence Data', 'Parasitic Sensitivity Tests', 'Protozoan Proteins', 'Sequence Analysis, DNA'] | 16,135,234 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D01.268.513.124', 'D01.268.556.050', 'D01.552.544.050'], ['D27.505.954.122.250.100'], ['A11.251'], ['G07.690.773.984'], ['G05.308'], ['B01.268.475.868.488'], ['L01.453.245.667'], ['E01.370.225.940', 'E05.200.940', 'E05.337.550.700'], ['D12.776.820'], ['E05.393... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Urethral amyloidosis]. | Localized amyloidosis of the urethra is a rare pathological entity. Biopsy is required to make the appropriate diagnosis. Although localized therapy is available for obstructing, symptomatic lesions, asymptomatic lesions may be followed with conservative management and spontaneous regression has been reported. An appro... | ['Adult', 'Amyloidosis', 'Humans', 'Male', 'Urethral Diseases'] | 11,899,740 | [['M01.060.116'], ['C18.452.845.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.767', 'C13.351.968.767']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The recruitment of leukocytes and their interaction with the vessel wall: the role of interleukin-1 and tumor necrosis factor. | The vascular endothelium has long been considered to have very little or no active function in inflammatory reactions and hemostasis. However, it has been recently discovered that endothelial cells can dramatically change their functional competence in response to the mononuclear phagocyte products interleukin-1 (IL-1)... | ['Chemotaxis, Leukocyte', 'Endothelium, Vascular', 'Humans', 'Interleukin-1', 'Leukocytes', 'Leukocytes, Mononuclear', 'Tumor Necrosis Factor-alpha'] | 3,502,509 | [['G04.198.424.233'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.465.131', 'D23.529.374.500.400'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy. | UNLABELLED: The present study describes the development of a good manufacturing practice (GMP)-grade liposomal nanotherapy containing prednisolone phosphate for the treatment of inflammatory diseases. After formulation design, GMP production was commenced which yielded consistent, stable liposomes sized 100nm±10nm, wit... | ['Animals', 'Anti-Inflammatory Agents', 'Aorta', 'Atherosclerosis', 'Chemistry, Pharmaceutical', 'Glucocorticoids', 'Half-Life', 'Humans', 'Liposomes', 'Male', 'Prednisolone', 'Rabbits', 'Rats', 'Rats, Sprague-Dawley', 'Rats, Wistar'] | 25,791,805 | [['B01.050'], ['D27.505.954.158'], ['A07.015.114.056'], ['C14.907.137.126.307'], ['H01.158.703.007', 'H01.181.466'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['D04.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
CO 2 laser surgery in hemophilia treatment. | The use of CO 2 laser surgery between 1985 and 1991 in South Africa and Portugal for treatment of disorders in patients with mild to moderate cases of hemophilia A is discussed. Six cases of oral procedures and excision of skin tumors performed during this period are reported. In most of the cases of mild hemophilia ... | ['Adult', 'Carbon Dioxide', 'Gingival Hemorrhage', 'Hemangioma', 'Hemophilia A', 'Hemorrhoids', 'Hemostasis, Surgical', 'Humans', 'Infant', 'Keratoacanthoma', 'Laser Therapy', 'Male', 'Middle Aged', 'Mouth Neoplasms', 'Papilloma', 'Skin Neoplasms'] | 10,183,941 | [['M01.060.116'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['C07.465.625.446', 'C07.465.714.258.250', 'C23.550.414.922.500'], ['C04.557.645.375'], ['C15.378.100.100.500', 'C15.378.100.141.500', 'C15.378.463.500', 'C16.320.099.500'], ['C06.405.469.860.401', 'C14.907.449'], ['E02.520.490', 'E04.350'], ['B01.050... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Novel beta-lactam derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome. | A series of beta-lactam derivatives has been designed and synthesized to inhibit the chymotrypsin-like activity of the human 20S proteasome. The most potent compounds of this new structural class of beta-subunit selective 20S proteasome inhibitors exhibit IC50 values in the low-nanomolar range and show good selectivity... | ['Chymotrypsin', 'Crystallography, X-Ray', 'Drug Design', 'Humans', 'Models, Molecular', 'Peptides', 'Proteasome Inhibitors', 'Structure-Activity Relationship', 'Trypsin Inhibitors', 'beta-Lactams'] | 17,095,212 | [['D08.811.277.656.300.760.176', 'D08.811.277.656.959.350.176'], ['E05.196.309.742.225'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['D12.644'], ['D27.505.519.389.745.705'], ['G02.111.830', 'G07.690.773.997'], ['D27.505.519.389.7... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Spermatozoa with high mitochondrial membrane potential and low tyrosine phosphorylation preferentially bind to oviduct explants in the water buffalo (Bubalus bubalis). | Although it is understood that spermatozoa are subjected to selection processes to form a functional sperm reservoir in the oviduct, the mechanism remains obscure. With the aim to understand the sperm selection process in the oviduct, in the present in vitro study, we analyzed mitochondrial membrane potential and tyros... | ['Animals', 'Buffaloes', 'Female', 'Male', 'Membrane Potential, Mitochondrial', 'Oviducts', 'Phosphorylation', 'Spermatozoa', 'Tissue Culture Techniques', 'Tyrosine'] | 28,262,463 | [['B01.050'], ['B01.050.150.900.649.313.500.380.135'], ['G03.295.770.500', 'G04.580.550', 'G07.265.675.550'], ['A13.706'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['A05.360.490.890', 'A11.497.760'], ['E05.481.500.617'], ['D12.125.072.050.875']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Iron overload augments the development of atherosclerotic lesions in rabbits. | Iron, a major oxidant in vivo, could be involved in atherosclerosis through the induction of the formation of oxidized LDL, a major atherogenic factor. This study was designed to test this hypothesis experimentally. Four groups of New Zealand White rabbits were included: iron-overloaded/hypercholesterolemic (group A, n... | ['Animals', 'Aorta', 'Arteriosclerosis', 'Cholesterol', 'Dextrans', 'Diet, Atherogenic', 'Ferritins', 'Hematocrit', 'Iron', 'Lipid Peroxides', 'Male', 'Rabbits'] | 7,542,998 | [['B01.050'], ['A07.015.114.056'], ['C14.907.137.126'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D05.750.078.562.272', 'D09.698.365.272'], ['G07.203.650.240.242'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['E01.370.225.625.400', 'E05.200.625.400', 'G09.188.370.374'], ['D01.268... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The first and second cinchona rearrangement. Two fundamental transformations of alkaloid chemistry. | Stereochemistry, products, and driving forces of the "first and second Cinchona rearrangement" have been investigated and a unified theory is presented. The first cage expansion affords [3.2.2]azabicyclic alpha-amino ether and is formulated via a configurationally stable bridgehead iminium ion and quasiequatorial nucle... | ['Animals', 'Aza Compounds', 'Bridged Bicyclo Compounds, Heterocyclic', 'Cinchona', 'Cinchona Alkaloids', 'Hydrolysis', 'Molecular Structure', 'Quinine', 'Silver', 'Stereoisomerism', 'Tartrates', 'Trifluoroethanol'] | 15,104,435 | [['B01.050'], ['D02.145'], ['D03.605.084'], ['B01.650.940.800.575.912.250.456.937.250'], ['D03.132.206'], ['G02.380'], ['G02.111.570', 'G02.466'], ['D03.132.206.719', 'D03.605.687.762', 'D03.633.100.810.762'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812'], ['G02.607.445.682'], ['D02.241.081.337.864', 'D02.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A University of California State-supported AIDS research award program--a unique state and university partnership in AIDS research. | This article describes the State-supported University of California AIDS research award program and its major accomplishments. It shows how a partnership between a University and a State resulted in the formation of a successful, efficient, and cost-effective AIDS research award program. This program provides funds for... | ['Acquired Immunodeficiency Syndrome', 'Awards and Prizes', 'California', 'Research', 'Research Support as Topic', 'Universities'] | 2,056,014 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['K01.150'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['H01.770.644'], ['N03.219.483.645'], ['I02.783.830', 'J03.832.830']] | ['Diseases [C]', 'Humanities [K]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
Serum lectins from the scorpion Vaejovis spinigerus Wood bind sialic acids. | We have partially characterized the specificity of serum lectins from the scorpion Vaejovis spinigerus Wood. Agglutination, crossed-absorption and hemagglutination-inhibition patterns were similar but not identical to serum lectins from other members from the family Vaejovidae , and different from the Buthidae species ... | ['Animals', 'Hemagglutinins', 'Lectins', 'Scorpions', 'Sialoglycoproteins', 'Species Specificity', 'Structure-Activity Relationship'] | 6,723,914 | [['B01.050'], ['D27.505.696.477.136.377'], ['D12.776.503'], ['B01.050.500.131.166.661'], ['D12.644.233.800', 'D12.776.395.700'], ['G16.824'], ['G02.111.830', 'G07.690.773.997']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Deepwater horizon oil spill: mental health effects on residents in heavily affected areas. | BACKGROUND: Mental health issues are a significant concern after disasters such as the Deepwater Horizon oil spill in the Gulf of Mexico in 2010. This study was designed to assess the mental health effects on residents of areas of southeastern Louisiana affected by the oil spill.METHODS: Telephone and face-to-face inte... | ['Adaptation, Psychological', 'Adolescent', 'Adult', 'Anxiety', 'Community Mental Health Services', 'Depression', 'Disasters', 'Female', 'Gulf of Mexico', 'Humans', 'Interview, Psychological', 'Louisiana', 'Male', 'Mental Health', 'Multivariate Analysis', 'Petroleum', 'Petroleum Pollution', 'Psychometrics', 'Public Hea... | 22,146,666 | [['F01.058'], ['M01.060.057'], ['M01.060.116'], ['F01.470.132'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['F01.145.126.350'], ['N06.230.100'], ['Z01.756.092.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.669.599'], ['Z01.107.567.875.750.480'], ['F02.418', 'N01.400.500'], ['E05.318.740.150.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
[McArdle's disease in a 14-year-old girl with fatigability and raised muscle enzymes]. | INTRODUCTION: McArdle's disease is a disorder of muscle energy metabolism caused by a deficit of muscle phosphorylase. The typical form presents with fatigability muscle cramps and pains triggered by physical exercise. Some cases have few symptoms. We report the case of a 14 year old girl diagnosed on finding a signifi... | ['Adolescent', 'Creatine Kinase', 'Energy Metabolism', 'Exercise', 'Exercise Test', 'Fatigue', 'Female', 'Glycogen Storage Disease Type V', 'Humans', 'Lactic Acid', 'Muscle, Skeletal', 'Phosphorylases', 'Pyruvic Acid'] | 10,919,189 | [['M01.060.057'], ['D08.811.913.696.640.150'], ['G03.295'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['C23.888.369'], ['C16.320.565.202.449.560', 'C18.452.648.202.449.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.511.459.450'], ['A02.633.567'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Vitamin A deficiency leads to severe functional disturbance of the intestinal epithelium enzymes associated with diarrhoea and increased bacterial translocation in gnotobiotic rats. | A disturbance of the integrity of the intestinal epithelium with an increased risk for bacterial translocation is one of the suggested factors underlying the increased incidence of infections and septicaemia during vitamin A deficiency. In the present study the effects of vitamin A deficiency on the enzymic activity of... | ['Animals', 'Bacteremia', 'Bacterial Translocation', 'Diarrhea', 'Enterocytes', 'Escherichia coli', 'Germ-Free Life', 'Jejunum', 'Microvilli', 'Rats', 'Rats, Wistar', 'Vitamin A Deficiency'] | 12,737,996 | [['B01.050'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['G06.099.114'], ['C23.888.821.214'], ['A03.556.124.369.290', 'A10.615.550.444.290', 'A11.436.290'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G06.320'], ['A03.556.124.684.500', 'A03.556.249.750'], ['A11.284.180.565'], ['B01.05... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hepatoprotective effects of ethanolic extract of Cnidoscolus aconitifolius on paracetamol-induced hepatic damage in rats. | The study was designed to evaluate the possible hepatoprotective effect of Cnidoscolus aconitifolius on paracetamol poisoning in rats. Twenty five male Wistar rats were used in this study. They were divided into 5 groups of 5 rats. Groups I and II received normal saline (0.9% physiological saline). Animal in groups III... | ['Acetaminophen', 'Analgesics, Non-Narcotic', 'Animals', 'Ethanol', 'Euphorbiaceae', 'Liver', 'Liver Diseases', 'Male', 'Plant Extracts', 'Random Allocation', 'Rats', 'Rats, Wistar'] | 20,437,682 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['D27.505.696.663.850.014.040', 'D27.505.954.427.040.100'], ['B01.050'], ['D02.033.375'], ['B01.650.940.800.575.912.250.859.797.438'], ['A03.620'], ['C06.552'], ['D20.215.784.500', 'D26.667'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Primary cleft nasal repair: the composite V-Y flap with extended mucosal tab. | A method of primary cleft lip nasal repair utilizing a medially based composite alar flap with a mucosal tab extension is presented. The procedure modifies, with a 5- to 6-mm mucosal tab extension, a previously described chondromucosal flap technique. Most cases were done concurrent with a modified Tennison lip repair.... | ['Cleft Lip', 'Humans', 'Nasal Septum', 'Surgical Flaps', 'Suture Techniques'] | 15,269,575 | [['C07.465.409.225', 'C07.465.525.164', 'C07.650.525.164', 'C16.131.850.525.164'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.531.591'], ['A10.850.710', 'E07.862.710'], ['E04.987.775']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reducing Barriers to Patient-Reported Outcome Measures for People With Cognitive Impairments. | The field of rehabilitation has increasingly called for the use of patient-reported outcome measures (PROMs) in research and practice. Given that many rehabilitation patients present with conditions associated with cognitive impairments, it is imperative to reduce barriers to PROM use for this population. The purpose o... | ['Cognitive Dysfunction', 'Humans', 'Patient Outcome Assessment', 'Patient Reported Outcome Measures', 'Physical Therapy Modalities'] | 28,400,180 | [['F03.615.250.700'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.559.590.399', 'N05.715.360.575.575.399'], ['E05.318.308.980.344.500', 'N03.349.380.210.750', 'N04.761.559.590.399.875', 'N05.425.210.500', 'N05.715.360.300.800.344.500', 'N05.715.360.575.575.399.875', 'N06.850.520.308.980.344.500'], ['E02.... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Is drug-induced hepatitis related to the severity of tuberculous meningitis? | Background: Drug-induced hepatitis (DIH) occurs more commonly in tuberculous meningitis (TBM) than non-CNS tuberculosis. We evaluate DIH in TBM and its relationship with disease severity and surrogate markers of stress.Methods: Sixty-seven patients with TBM were included prospectively. The diagnosis of DIH was based on... | ['Adult', 'Aged', 'Alanine Transaminase', 'Antitubercular Agents', 'Bilirubin', 'Chemical and Drug Induced Liver Injury', 'Female', 'Hepatitis, Autoimmune', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Severity of Illness Index', 'Stress, Physiological', 'Tuberculosis, Meningeal', 'Young Adult'] | 29,438,557 | [['M01.060.116'], ['M01.060.116.100'], ['D08.811.913.477.700.100'], ['D27.505.954.122.085.255'], ['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['C06.552.380.350.300', 'C20.111.567'], ['B01.050.150.900.649.313.988.400.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The place of Homo floresiensis in human evolution. | Two main evolutionary scenarios have been proposed to explain the presence of the small-bodied and small-brained Homo floresiensis species on the remote Indonesian island of Flores in the Late Pleistocene. According to these two scenarios, H. floresiensis was a dwarfed descendent of H. erectus or a late-surviving remna... | ['Animals', 'Anthropology, Physical', 'Biological Evolution', 'Body Size', 'Hominidae'] | 26,829,572 | [['B01.050'], ['I01.076.368'], ['G05.045', 'G16.075'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['B01.050.150.900.649.313.988.400.112.400']] | ['Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Impact of a parenting program in a high-risk, multi-ethnic community: the PALS trial. | BACKGROUND: Parenting programs have been shown to work when delivered to motivated ethnic majority parents in demonstration projects, but comparatively little is known about their impact when delivered to high-risk, multi-ethnic populations by routine local services.METHODS: The Primary Age Learning Skills (PALS) trial... | ['Adult', 'Child', 'Child Behavior', 'Child Behavior Disorders', 'Child, Preschool', 'Ethnic Groups', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Outcome and Process Assessment, Health Care', 'Parent-Child Relations', 'Parenting', 'Parents', 'Psychometrics', 'Reading', 'Residence Characteristics', 'Social Environ... | 20,868,373 | [['M01.060.116'], ['M01.060.406'], ['F01.145.179'], ['F03.625.141'], ['M01.060.406.448'], ['M01.686.754', 'N01.224.317'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.559', 'N05.715.360.575'], ['F01.829.263.370.290'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
[Gerasimov effect of an alternating magnetic field on clinical characteristics of peripheral blood from women suffering tuboperitoneal infertility of inflammatory origin]. | The influence of an alternating magnetic field (AMF) on the number of erythrocytes, hemoglobin level, erythrocyte sedimentation rate, differential blood cell count, and pH values in peripheral blood was studied in 15 woman volunteers suffering tuboperitoneal infertility (TPI) of inflammatory origin. They were found to ... | ['Adult', 'Blood Sedimentation', 'Erythrocyte Count', 'Female', 'Humans', 'Hydrogen-Ion Concentration', 'Infertility, Female', 'Inflammation', 'Leukocyte Count', 'Magnetic Field Therapy'] | 20,017,383 | [['M01.060.116'], ['E01.370.225.625.125', 'E05.200.625.125'], ['E01.370.225.500.195.107.330', 'E01.370.225.625.107.330', 'E05.200.500.195.107.330', 'E05.200.625.107.330', 'E05.242.195.107.330', 'G04.140.107.330', 'G09.188.105.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['C13.351.500.365.700'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Considerations and results of the use of paramomycin in the prevention of infectious complications in colorectal surgery]. | The efficacy of short term prophylaxis in the prevention of infection has been tested in 72 patients who underwent surgical treatment for colorectal pathology. General tolerance to the antibiotics was good. The Authors took this remark as a starting point for reviewing the literature and making comments. | ['Adenocarcinoma', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Colonic Neoplasms', 'Colonic Polyps', 'Colorectal Surgery', 'Diverticulitis', 'Female', 'Humans', 'Male', 'Middle Aged', 'Paromomycin', 'Postoperative Complications', 'Rectal Neoplasms', 'Sigmoid Neoplasms', 'Surgical Wound Infection', 'Urinary T... | 12,164,005 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['C23.300.825.411.235'], ['H02.403.810.208'], ['C06.405.205.282.500'], ['B01.050.1... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Socioeconomic status, access to health care, and outcomes after acute myocardial infarction in Canada's universal health care system. | BACKGROUND: There is a debate as to whether universal drug coverage confers similar access to care at all socioeconomic status (SES) levels. Experiences in Canada may bring light to questions raised regarding access.OBJECTIVE: To assess associations between SES and access to cardiac care and outcomes in Canada's univer... | ['Aged', 'Bayes Theorem', 'British Columbia', 'Cardiovascular Agents', 'Female', 'Health Services Accessibility', 'Humans', 'Insurance Coverage', 'Insurance, Pharmaceutical Services', 'Male', 'Myocardial Infarction', 'National Health Programs', 'Ontario', 'Patient Readmission', 'Quebec', 'Socioeconomic Factors', 'Treat... | 17,571,012 | [['M01.060.116.100'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['Z01.107.567.176.160'], ['D27.505.954.411'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.265'], ['N03.219.521.576.343.575'], ['C14.280.647.500', 'C14.907.585.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Breed differences in fetal and placental development and feto-maternal amino acid status following nutrient restriction during early and mid pregnancy in Scottish Blackface and Suffolk sheep. | This study assessed the effect of feeding 0.75 energy requirements between Days 1 and 90 of pregnancy on placental development and feto-placental amino acid status on Day 125 of pregnancy in Scottish Blackface and Suffolk ewes carrying a single fetus. Such moderate nutrient restriction did not affect placental size, pl... | ['Amino Acids', 'Animal Nutritional Physiological Phenomena', 'Animals', 'Body Weight', 'Breeding', 'Energy Metabolism', 'Female', 'Fetal Development', 'Fetus', 'Hydrocortisone', 'Maternal-Fetal Exchange', 'Organ Size', 'Placenta', 'Placentation', 'Pregnancy', 'Pregnancy, Animal', 'Prenatal Nutritional Physiological Ph... | 22,127,007 | [['D12.125'], ['G07.203.650.161'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E05.820.150', 'G05.090'], ['G03.295'], ['G07.345.500.325.235', 'G08.686.784.170.157'], ['A16.378'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Understanding learning transfer of veterans in baccalaureate nursing programs: Their experience as student nurses. | With the continued growth of the numbers of veterans in nursing programs, faculty need to be aware of how to best facilitate their learning and build on their diverse experiences and expertise. Understanding how veterans transfer learning from the military context to an academic context is crucial for nursing education... | ['Adult', 'Clinical Competence', 'Education, Nursing, Baccalaureate', 'Faculty, Nursing', 'Female', 'Humans', 'Male', 'Problem-Based Learning', 'Qualitative Research', 'Students, Nursing', 'Veterans'] | 31,449,991 | [['M01.060.116'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.358.462.316'], ['M01.526.485.390', 'M01.526.702.250.473', 'N02.360.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.720', 'I02.158.660', 'I02.903.565'], ['H01.770.644.241.850'], ['M01.848.769.685'], ['M01.930']] | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Allergens in bee venom. III. Identification of allergen B of bee venom as an acid phosphatase. | Allergen B previously isolated from honeybee venom and shown to be a mildly acidic protein consisting of polymers of a chain of 49,000 d is shown to have acid phosphatase activity. Allergen B is homogeneous by several criteria. No acid phosphatase, alkaline phosphatase, or esterase activity was found in any other aller... | ['Acid Phosphatase', 'Allergens', 'Bees', 'Hyaluronoglucosaminidase', 'Hymenoptera', 'Melitten', 'Phospholipases', 'Venoms'] | 853,176 | [['D08.811.277.352.650.025'], ['D23.050.063'], ['B01.050.500.131.617.720.500.500.875.387'], ['D08.811.277.450.529', 'D08.811.520.241.700.675'], ['B01.050.500.131.617.720.500.500.875'], ['D12.644.050.550', 'D12.776.543.695.054.550', 'D20.888.065.115.580', 'D23.946.833.065.115.580'], ['D08.811.277.352.100.680', 'D08.811.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibitor and substrate binding by New Delhi metallo-beta-lactamase-1: a molecular dynamics studies. | The control of beta-lactam antibiotics released through the inhibition of the New Delhi metallo-beta-lactamase 1 (NDM-1) has been identified as a potential target for the treatment of the muti-drugs resistance (MDR) bacteria disease. We have employed molecular dynamics (MD), alanine-scanning mutagenesis and molecular d... | ['Anti-Bacterial Agents', 'Drug Resistance, Multiple, Bacterial', 'Humans', 'Molecular Docking Simulation', 'Molecular Dynamics Simulation', 'beta-Lactamase Inhibitors', 'beta-Lactamases', 'beta-Lactams'] | 25,479,381 | [['D27.505.954.122.085'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595.249', 'L01.224.160.249'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['D27.505.519.389.400', 'D27.505.954.122.085.516... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Retinoid metabolism in spontaneously transformed mouse fibroblasts (Balb/c 3T12-3 cells): enzymatic conversion of retinol to anhydroretinol. | Spontaneously transformed mouse fibroblasts (Balb/c 3T12-3 cells) displayed an increased adhesion when cultured in the presence of 10(-6) M all-trans retinol and acquired morphological characteristics of the normal phenotype. Thus it was of interest to investigate the metabolism of [15-(14)C]retinol in this system. Wit... | ['Animals', 'Animals, Newborn', 'Cell Adhesion', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Fibroblasts', 'Intestinal Mucosa', 'Mice', 'Mice, Inbred BALB C', 'Microsomes', 'Models, Biological', 'Skin', 'Tretinoin', 'Vitamin A'] | 448,240 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Different on the inside: extreme swimbladder sexual dimorphism in the South Asian torrent minnows. | The swimbladder plays an important role in buoyancy regulation but is typically reduced or even absent in benthic freshwater fishes that inhabit fast flowing water. Here, we document, for the first time, a remarkable example of swimbladder sexual dimorphism in the highly rheophilic South Asian torrent minnows (Psilorhy... | ['Air Sacs', 'Animals', 'Cyprinidae', 'Female', 'Male', 'Phylogeny', 'Rivers', 'Sex Characteristics'] | 25,009,242 | [['A13.048'], ['B01.050'], ['B01.050.150.900.493.200.244'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['G08.686.815']] | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Involvement of the heparanase procoagulant domain in bleeding and wound healing. | Essentials Heparanase forms a complex with tissue factor and enhances the generation of factor Xa. The present study was aimed to identify the procoagulant domain of heparanase. Procoagulant peptides significantly shortened bleeding time and enhanced wound healing. Tissue factor pathway inhibitor (TFPI)-2 derived pepti... | ['Animals', 'Blood Coagulation', 'Coagulants', 'Factor Xa', 'Fibrin Fibrinogen Degradation Products', 'Fibrinogen', 'Glucuronidase', 'Glycoproteins', 'Hematologic Agents', 'Hemorrhage', 'Humans', 'Inflammation', 'Male', 'Mice', 'Neoplasm Metastasis', 'Neovascularization, Pathologic', 'Partial Thromboplastin Time', 'Pep... | 28,439,967 | [['B01.050'], ['G09.188.390.150'], ['D27.505.954.502.270'], ['D08.811.277.656.300.760.315', 'D08.811.277.656.959.350.315', 'D12.776.124.125.400.315', 'D23.119.400.315'], ['D12.776.124.270.300', 'D12.776.811.300.290'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['D08.811.277.450.42... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hypoplastic acute leukemia: review of 70 cases with multivariate regression analysis. | Between 1971 and 1984, 22 of 190 adult patients (11.6 per cent) with acute leukemia seen at the University of Arizona had hypocellular acute leukemia (HAL), defined as lymphoblasts or myeloblasts (plus atypical promyelocytes) of greater than or equal to 30 per cent, but marrow cellularity of the core biopsy or clot sec... | ['Acute Disease', 'Adult', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Female', 'Humans', 'Leukemia', 'Male', 'Middle Aged', 'Prognosis', 'Retrospective Studies'] | 3,557,323 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337'], ['M01.060.116.630'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The meaning of attempted suicide to young parasuicides: a repertory grid study. | In an attempt to clarify the intentional aspect of parasuicide, constructs in response to a supposed crisis were elicited from a group of overdose patients, using the standard method of contrasting elements. In this case the elements were presented as a list of 11 alternative behaviours (including overdose and suicide)... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Poisoning', 'Suicide, Attempted'] | 7,326,540 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['C25.723'], ['F01.145.126.980.875.600', 'I01.880.735.856.600']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Multiple antibiotic resistance genes distribution in ten large-scale membrane bioreactors for municipal wastewater treatment. | Wastewater treatment plants are thought to be potential reservoirs of antibiotic resistance genes. In this study, GeoChip was used for analyzing multiple antibiotic resistance genes, including four multidrug efflux system gene groups and three â-lactamase genes in ten large-scale membrane bioreactors (MBRs) for municip... | ['Actinobacteria', 'Anti-Bacterial Agents', 'Bioreactors', 'China', 'Drug Resistance, Microbial', 'Membranes, Artificial', 'Proteobacteria', 'Waste Disposal, Fluid', 'Waste Water', 'beta-Lactamases'] | 27,716,561 | [['B03.510.024', 'B03.510.460.400.400.049'], ['D27.505.954.122.085'], ['E07.115', 'J01.897.120.115'], ['Z01.252.474.164'], ['G06.225', 'G07.690.773.984.269'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['B03.660'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['D20.944.932', 'N06.850.460.710.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Deficient phagocytic function in Papillon-Lef?vre syndrome. | The function of microphages has been studied in vitro in a 5 year-old girl with Papillon-Lef?vre syndrome. The results showed a weakness in chemotatic activity, a defect of intracellular killing of Staphylococcus aureus, and an almost normal phagocytosis but decreased intracellular killing of Candida albicans by the mi... | ['Chemotaxis, Leukocyte', 'Child, Preschool', 'Female', 'Humans', 'Keratoderma, Palmoplantar', 'Papillon-Lefevre Disease', 'Phagocytosis'] | 146,625 | [['G04.198.424.233'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C16.320.850.475', 'C17.800.428.435', 'C17.800.827.475'], ['C16.320.850.475.600', 'C17.800.428.435.600', 'C17.800.827.475.600'], ['G04.417.350', 'G09.188.665', 'G12.450.564.809', 'G12.688']] | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Diet and risk of lymphoid neoplasms and soft tissue sarcomas. | The relationship between frequency of intake of selected indicator foods, lymphoid neoplasms, and soft tissue sarcomas was investigated in an updated case-control study conducted in Northern Italy between 1983 and 1992 on 158 incident, histologically confirmed cases of Hodgkin's disease (HD), 429 cases of non-Hodgkin's... | ['Adolescent', 'Adult', 'Aged', 'Animals', 'Case-Control Studies', 'Daucus carota', 'Diet', 'Dietary Fats', 'Edible Grain', 'Female', 'Fishes', 'Hodgkin Disease', 'Humans', 'Lymphoma, Non-Hodgkin', 'Male', 'Multiple Myeloma', 'Odds Ratio', 'Risk Factors', 'Sarcoma', 'Vegetables'] | 9,101,555 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.650.940.800.575.912.250.075.278'], ['G07.203.650.240'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['A18.024.500.750.500', 'B01.650.160.250', 'B01.650.510.250... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Ophthalmologic abnormalities among students with cognitive impairment in eastern Taiwan: The special group with undetected visual impairment. | PURPOSE: Students with cognitive impairment are at increased risk of suffering from visual impairment due to refractive errors and ocular disease, which can adversely influence learning and daily activities. The purpose of this study was to evaluate the ocular and visual status among students at the special education s... | ['Adolescent', 'Child', 'Cognitive Dysfunction', 'Disabled Children', 'Education, Special', 'Eye Diseases', 'Eyeglasses', 'Female', 'Humans', 'Male', 'Prevalence', 'Refractive Errors', 'Risk Factors', 'Taiwan', 'Vision Disorders', 'Visual Acuity'] | 27,742,159 | [['M01.060.057'], ['M01.060.406'], ['F03.615.250.700'], ['M01.150.200'], ['I02.233.213'], ['C11'], ['E07.632.500.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['C11.744'], ['E05.318.740.600.800.72... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Extracorporeal shock wave therapy does not improve hypertensive nephropathy. | Low-energy extracorporeal shock wave therapy (SWT) has been shown to improve myocardial dysfunction, hind limb ischemia, erectile function, and to facilitate cell therapy and healing process. These therapeutic effects were mainly due to promoting angiogenesis. Since chronic kidney diseases are characterized by renal fi... | ['Animals', 'Disease Models, Animal', 'Hypertension, Renal', 'Kidney', 'Lithotripsy', 'Male', 'NG-Nitroarginine Methyl Ester', 'Nephritis', 'Rats', 'Treatment Outcome'] | 27,255,359 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C12.777.419.331', 'C13.351.968.419.331', 'C14.907.489.631'], ['A05.810.453'], ['E02.600', 'E04.943.500'], ['D12.125.068.050.525', 'D12.125.095.104.525'], ['C12.777.419.570', 'C13.351.968.419.570'], ['B01.050.150.900.649.313.992.635.505.700'], ['E01.789.800'... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ixodes eldaricus Djaparidze, 1950 (Ixodidae) on migrating birds--reported first time in Poland. | During the ornithological "Operation Baltic" on the Hel Peninsula (the Baltic Sea coast in Poland) the first case of transfer to Poland of ticks of the species Ixodes eldaricus Djaparidze, 1950, on Prunella modularis (one female tick) and Erithacus rubecula (two males and one female tick). P. modularis and E. rubecula ... | ['Animal Migration', 'Animals', 'Bird Diseases', 'Brief Psychiatric Rating Scale', 'Female', 'Ixodes', 'Male', 'Mite Infestations', 'Passeriformes', 'Poland'] | 22,142,944 | [['F01.145.113.069.500'], ['B01.050'], ['C22.131'], ['F04.711.513.653.083'], ['B01.050.500.131.166.132.832.400.425'], ['C01.610.858.211.480'], ['B01.050.150.900.248.620'], ['Z01.542.248.679']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Stimulation-dependent release of adenosine triphosphate from hippocampal slices. | Schaffer collaterals of rat and mouse hippocampal slices were stimulated with bursts of pulses (300 Hz for 50 ms, 2-s intervals) for 30-s which caused a stable increase in the size of the population spike known as long-term potentiation. The release of adenosine triphosphate (ATP) was measured with a luciferase-lucifer... | ['Action Potentials', 'Adenosine Triphosphate', 'Animals', 'Electric Stimulation', 'Glutamates', 'Glutamic Acid', 'Hippocampus', 'In Vitro Techniques', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Rats', 'Rats, Inbred Strains'] | 2,566,360 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['E05.723.402'], ['D12.125.067.625', 'D12.125.119.409'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['A08.186.211.180.405', 'A08.186.211.200.885.287... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Granulomatous tonsillitis. A rare extraintestinal manifestation of Crohn's disease. | Oral lesions, varying in nature and location, appear to be one of the common extraintestinal manifestation of Crohn's disease. In particular, oral involvement preceding intestinal disease may lead to the diagnosis of Crohn's disease. The present case report of a 17-year-old male patient describes a very rare nonintesti... | ['Adolescent', 'Crohn Disease', 'Granuloma, Giant Cell', 'Humans', 'Male', 'Palatine Tonsil', 'Tonsillitis'] | 1,618,062 | [['M01.060.057'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['C05.500.368', 'C07.320.391', 'C07.465.714.258.557', 'C23.550.382.468'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.623.603.925', 'A10.549.580', 'A14.724.603.925', 'A15.382.520.604.580'], ['C01.748.561.750', 'C07.550.781.750', 'C08.730.561.7... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Dose delivered to the patient by megavoltage cone beam computed tomography imaging]. | PURPOSE: To study the dose delivered by a megavoltage cone beam computed tomography imaging system (MVCBCT) installed on a Oncor Impression linac (Siemens).MATERIALS AND METHODS: The acquisition of MVCBCT images was modelled in a treatment planning system by 67 photon beams (6 MV). A study was conducted to: compare the... | ['Cone-Beam Computed Tomography', 'Femur Head', 'Humans', 'Male', 'Particle Accelerators', 'Pelvis', 'Phantoms, Imaging', 'Prostatic Neoplasms', 'Radiation Dosage', 'Radiotherapy, Conformal', 'Rectum', 'Urinary Bladder'] | 19,640,758 | [['E01.370.350.700.810.810.490', 'E01.370.350.825.810.810.399'], ['A02.835.232.043.150.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.710.680'], ['A01.923.600'], ['E07.671'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Bacterial reduction of alcohol-based liquid and gel products on hands soiled with blood. | The antibacterial efficacy of three alcohol-based products (liquid and gel) were tested on the hands with blood and contaminated with Serratia marcescens (ATCC 14756), using EN 1500 procedures in 14 healthy volunteers. The alcohol-based products tested, either gel or liquid-based, reached bacterial reduction levels hig... | ['Adolescent', 'Adult', 'Alcohols', 'Bacterial Load', 'Blood', 'Disinfectants', 'Female', 'Hand', 'Hand Disinfection', 'Humans', 'Male', 'Middle Aged', 'Serratia marcescens', 'Young Adult'] | 21,705,110 | [['M01.060.057'], ['M01.060.116'], ['D02.033'], ['E01.370.225.875.150.115', 'E01.370.225.875.220.115', 'E05.200.875.150.115', 'E05.200.875.220.115', 'G06.099.100'], ['A12.207.152', 'A15.145'], ['D27.505.954.122.425', 'D27.720.274'], ['A01.378.800.667'], ['N06.850.670.150.500'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Immunohistochemical study of the pancreatic endocrine cells in the BALB/c mice: an unique distributional pattern of glucagon. | The regional distribution and relative frequency of insulin-, glucagon-, somatostatin- and pancreatic polypeptide (PP)-producing endocrine cells in the pancreas of BALB/c mouse were investigated by immunohistochemical method. The pancreas of mice was divided into two portions; pancreatic islets and exocrine portions, a... | ['Animals', 'Female', 'Glucagon', 'Immunohistochemistry', 'Insulin', 'Islets of Langerhans', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Pancreatic Polypeptide', 'Somatostatin'] | 12,514,327 | [['B01.050'], ['D06.472.699.587.730.500', 'D12.644.548.586.730.500'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['D06.472.699.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The relative affinity of transferrin and albumin for zinc. | The relative affinity of transferrin and albumin for zinc has been measured by competitive dialysis at a low zinc concentration in 0.15 M NaCl, 50 mM HEPES, 0.1 mM trisodium citrate (pH 7.2). There were small differences between albumins and larger ones between transferrin preparations, but all albumins bound zinc more... | ['Humans', 'Osmolar Concentration', 'Protein Binding', 'Serum Albumin', 'Transferrin', 'Zinc'] | 518,914 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reduction in excess daytime sleepiness by modafinil in patients with myotonic dystrophy. | Patients with myotonic dystrophy frequently suffer from excess daytime sleepiness, which can be a significant cause of disability. Previous studies have indicated that this excess daytime sleepiness is only occasionally due to obstructive sleep apnoea and may be principally of central nervous system origin. Modafinil h... | ['Adult', 'Aged', 'Benzhydryl Compounds', 'Central Nervous System Stimulants', 'Cross-Over Studies', 'Disorders of Excessive Somnolence', 'Double-Blind Method', 'Female', 'Humans', 'Male', 'Middle Aged', 'Modafinil', 'Myotonic Dystrophy', 'Neuropsychological Tests', 'Polysomnography', 'Surveys and Questionnaires', 'Tre... | 12,798,791 | [['M01.060.116'], ['M01.060.116.100'], ['D02.455.426.559.389.115'], ['D27.505.696.282', 'D27.505.954.427.220'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['C10.886.425.800.200', 'F03.870.400.800.200'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries. | Quantum dots (QD) have unique electronic and optical properties promoting biotechnological advances. However, our understanding of the toxicological structure-activity relationships remains limited. This study aimed to determine the biological impact of varying nanomaterial surface chemistry by assessing the interactio... | ['Cadmium', 'Cell Line', 'DNA Damage', 'Humans', 'Lymphocytes', 'Mutagenicity Tests', 'Mutagens', 'Oxidative Stress', 'Quantum Dots', 'Selenium', 'Semiconductors', 'Structure-Activity Relationship', 'Surface Properties'] | 26,275,419 | [['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['A11.251.210'], ['G05.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['E05.393.560', 'E05.940.560'], ['D27.888.569.468'], ['G03.673', 'G07.775.750'], ['E07.705', 'J01.637.512.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Molecular pathways: microsatellite instability in colorectal cancer: prognostic, predictive, and therapeutic implications. | Microsatellite instability (MSI) is the molecular fingerprint of the deficient mismatch repair (MMR) system, which characterizes ?15% of colorectal cancers. MSI develops as a result of germline mutations in MMR genes or, more commonly, from epigenetic silencing of MLH1 in sporadic tumors occurring in a background of me... | ['Adaptor Proteins, Signal Transducing', 'Colorectal Neoplasms', 'CpG Islands', 'DNA Methylation', 'DNA Mismatch Repair', 'Genetic Heterogeneity', 'Humans', 'MicroRNAs', 'Microsatellite Instability', 'MutL Protein Homolog 1', 'Mutation', 'Nuclear Proteins', 'Predictive Value of Tests', 'Prognosis', 'Promoter Regions, G... | 22,302,899 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['G02.111.570.080.380.160', 'G05.360.080.380.160', 'G05.360.340.024.159'], ['G02.111.035.538.161', 'G02.111.218', 'G... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Physical and functional interaction of the Arabidopsis K(+) channel AKT2 and phosphatase AtPP2CA. | The AKT2 K(+) channel is endowed with unique functional properties, being the only weak inward rectifier characterized to date in Arabidopsis. The gene is expressed widely, mainly in the phloem but also at lower levels in leaf epiderm, mesophyll, and guard cells. The AKT2 mRNA level is upregulated by abscisic acid. By ... | ['Abscisic Acid', 'Animals', 'Arabidopsis', 'Arabidopsis Proteins', 'COS Cells', 'DNA, Complementary', 'Gene Expression Regulation, Enzymologic', 'Gene Expression Regulation, Plant', 'Oocytes', 'Phosphoprotein Phosphatases', 'Plant Epidermis', 'Plant Proteins', 'Plant Roots', 'Plant Shoots', 'Potassium Channels', 'Prot... | 12,034,902 | [['D02.241.223.268.034', 'D02.455.326.271.665.202.061', 'D02.455.426.392.368.367.379.249.024', 'D02.455.849.131.061', 'D02.455.849.765.521.500'], ['B01.050'], ['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['A11.251.210.172.500', 'A11.329.228.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Detection of early retinal changes in diabetes by vitreous fluorophotometry. | A series of 77 patients with overt diabetes and with apparently normal fundi on ophthalmoscopy and fluorescein angiography was examined by vitreous fluorophotometry. Breakdown of the blood-retinal barrier, which appears to be the earliest clinically detectable change in the retina in diabetes, was a constant finding. Q... | ['Diabetic Retinopathy', 'Female', 'Fluorometry', 'Humans', 'Male', 'Retina', 'Time Factors', 'Vitreous Body'] | 759,246 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transplant vasculopathy: viral anti-inflammatory serpin regulation of atherogenesis. | BACKGROUND: Surgical and ischemic injury to the artery wall initiates vascular wound-healing responses that stimulate atherosclerotic plaque growth. The plasminogen activators have cellular chemotactic, adhesion, and proteolytic activity. Serp-1 is a secreted myxoma virus glycoprotein serpin that binds and inhibits pla... | ['Angioplasty, Balloon', 'Animals', 'Aorta', 'Arteriosclerosis', 'Chickens', 'Coronary Artery Disease', 'Female', 'Heart Transplantation', 'Humans', 'Male', 'Plasminogen Activators', 'Postoperative Complications', 'Rabbits', 'Rats', 'Rats, Sprague-Dawley', 'Serpins', 'Swine', 'Swine, Miniature', 'Tunica Intima', 'Tunic... | 11,077,219 | [['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['B01.050'], ['A07.015.114.056'], ['C14.907.137.126'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['E04.100.376.475', 'E04.928.220.390', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of water-soluble low-molecular-weight beta-1, 3-D-glucan (branch beta-1, 6) isolated from Aureobasidium pullulans 1A1 strain black yeast on restraint stress in mice. | It is well known that different stress paradigms are able to rapidly induce corticosterone production and immune function through the activation of the hypothalamic-pituitary-adrenal axis. It has been reported that glucocorticoids suppress natural killer (NK) activity and interleukin (IL)-1 production and, on the other... | ['Animals', 'Ascomycota', 'Corticosterone', 'Dose-Response Relationship, Drug', 'Glucans', 'Interleukin-12', 'Interleukin-6', 'Killer Cells, Natural', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Organ Size', 'Restraint, Physical', 'Spleen', 'Stress, Psychological'] | 17,725,857 | [['B01.050'], ['B01.300.107'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['G07.690.773.875', 'G07.690.936.500'], ['D05.750.078.562', 'D09.698.365'], ['D12.644.276.374.465.512', 'D12.776.467.374.465.512', 'D23.529.374.465.512'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.465.22... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cost-effective but clinically inappropriate: new NICE intervention thresholds in osteoporosis (Technology Appraisal 464). | PURPOSE: To comment on the latest technology appraisal of the National Institute for Clinical Excellence (NICE) in osteoporosis.METHODS: Review of NICE Technology Appraisal (TA464) on bisphosphonate use in osteoporosis.RESULTS: The NICE appraisal on bisphosphonate use in osteoporosis indicates that treatment with oral ... | ['Bone Density', 'Bone Density Conservation Agents', 'Cost-Benefit Analysis', 'Decision Support Techniques', 'Diphosphonates', 'Evidence-Based Medicine', 'Humans', 'Osteoporosis', 'Osteoporotic Fractures', 'Risk Assessment', 'United Kingdom'] | 29,947,864 | [['G11.427.100'], ['D27.505.696.242'], ['N03.219.151.125'], ['E05.245', 'L01.313.500.750.190'], ['D02.705.429.500'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.198.579', 'C18.452.104.579'], ['C26.404.545'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.7... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Ratio of urinary potassium to urinary sodium and the potassium and edema status in nephrotic syndrome. | OBJECTIVE: This study aimed to evaluate the relevance of ratios of urinary potassium to urinary sodium + potassium (U(K)/U(Na + K)) to edema status in minimal-change nephrotic syndrome (MCNS).METHODS: We retrospectively studied 26 adults with newly diagnosed MCNS with significant pitting edema. On the basis of mean val... | ['Adult', 'Biomarkers', 'Edema', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nephrotic Syndrome', 'Patient Admission', 'Potassium', 'Retrospective Studies', 'Sodium'] | 21,422,677 | [['M01.060.116'], ['D23.101'], ['C23.888.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C12.777.419.630.643', 'C13.351.968.419.630.643'], ['E02.760.400.600', 'N02.421.585.400.600'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['E05.318.372.500.500.500', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The PVT gene frequently amplifies with MYC in tumor cells. | The line of human colon carcinoma cells known as COLO320-DM contains an amplified and abnormal allele of the proto-oncogene MYC (DMMYC). Exon 1 and most of intron 1 of MYC have been displaced from DMMYC by a rearrangement of DNA. The RNA transcribed from DMMYC is a chimera that begins with an ectopic sequence of 176 nu... | ['Alleles', 'Animals', 'Base Sequence', 'Chimera', 'Cloning, Molecular', 'Colonic Neoplasms', 'DNA', 'Exons', 'Gene Amplification', 'Humans', 'Introns', 'Mice', 'Molecular Sequence Data', 'Oncogenes', 'RNA, Neoplasm', 'Transcription, Genetic', 'Tumor Cells, Cultured'] | 2,725,491 | [['G05.360.340.024.340.030'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B05.200'], ['E05.393.220'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D13.444.308'], ['G05.360.340.024.340.137.232'... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bonnevillamides, Linear Heptapeptides Isolated from a Great Salt Lake-Derived Streptomyces sp. | Streptomyces sp. GSL-6B was isolated from sediment collected from the Great Salt Lake and investigation of its organic extract led to the isolation of three new linear heptapeptides, bonnevillamides A (1), B (2), and C (3). The bonnevillamides represent a new class of linear peptides featuring unprecedented non-protein... | ['Animals', 'Dose-Response Relationship, Drug', 'Embryo, Nonmammalian', 'Lakes', 'Larva', 'Models, Molecular', 'Molecular Structure', 'Peptides', 'Streptomyces', 'Utah', 'Zebrafish'] | 28,672,784 | [['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['A13.350', 'A16.331'], ['G01.311.580', 'G16.500.275.280.500', 'N06.230.232.500'], ['B05.500.500', 'G07.345.500.550.500.500'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['D12.644'], ['B03.300.390.400.810.768', 'B03.510.024.997.775', 'B03.510.415.400.810.768', 'B0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Preparation of human epidermal keratinocyte cultures. | Cultured keratinocytes have been used by a number of investigators in studies investigating wound repair and carcinogenesis, and they have also proven useful as a model for differentiation. This unit describes a protocol for establishing human keratinocytes in tissue culture. Human newborn foreskins are proteolytically... | ['Cell Culture Techniques', 'Cell Separation', 'Culture Media', 'Epidermal Cells', 'Foreskin', 'Humans', 'Infant, Newborn', 'Keratinocytes', 'Male', 'Trypsin'] | 18,228,450 | [['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['D27.720.470.305', 'E07.206'], ['A11.409'], ['A05.360.444.492.362'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['A11.409.500', 'A11.436.397'], ['D08.811.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Identification and antimicrobial susceptibility of porcine bacteria that inhibit the growth of Brachyspira hyodysenteriae in vitro. | AIMS: To identify bacilli, lactic acid bacteria and bifidobacteria that inhibit the growth of Brachyspira hyodysenteriae.METHODS AND RESULTS: A total of 80 isolates were obtained from various porcine intestinal compartments using selective conditions and grouped into 15 similarity clusters based on whole-cell protein p... | ['Animals', 'Anti-Bacterial Agents', 'Bacteria', 'Brachyspira hyodysenteriae', 'DNA, Ribosomal', 'Gastrointestinal Tract', 'Gram-Negative Bacterial Infections', 'Microbial Interactions', 'Microbial Sensitivity Tests', 'Phylogeny', 'Probiotics', 'Swine', 'Swine Diseases'] | 19,778,354 | [['B01.050'], ['D27.505.954.122.085'], ['B03'], ['B03.440.097.100', 'B03.440.425.410.220.100'], ['D13.444.308.475'], ['A03.556'], ['C01.150.252.400'], ['G06.550'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G07.203.300.456.500', 'J02.500.456.500'], ['B01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Development of language in Rett syndrome. | Ninety-nine cases of Rett syndrome (RTT) diagnosed clinically (age range 3 years 6 months to 29 years 9 months) were evaluated for the ability of language. The presence of meaningful words, vocabularies, and ages at the start and disappearance of speech were assessed. Phenotype/genotype correlation was evaluated in 22 ... | ['Adolescent', 'Adult', 'Aging', 'Child', 'Child, Preschool', 'Chromosomal Proteins, Non-Histone', 'DNA Mutational Analysis', 'DNA-Binding Proteins', 'Female', 'Humans', 'Language Development Disorders', 'Methyl-CpG-Binding Protein 2', 'Middle Aged', 'Repressor Proteins', 'Rett Syndrome', 'Speech'] | 11,738,880 | [['M01.060.057'], ['M01.060.116'], ['G07.345.124'], ['M01.060.406'], ['M01.060.406.448'], ['D12.776.660.235', 'D12.776.664.235'], ['E05.393.760.700.300'], ['D12.776.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.150.500.550', 'C23.888.592.604.150.500.550'], ['D12.776.260.536', 'D12.776.660.235.55... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Right and left perisylvian cortex and left inferior frontal cortex mediate sentence-level rhyme detection in spoken language as revealed by sparse fMRI. | In this study, we used functional magnetic resonance imaging to investigate the neural basis of auditory rhyme processing at the sentence level in healthy adults. In an explicit rhyme detection task, participants were required to decide whether the ending syllable of a metrically spoken pseudosentence rhymed or not. Pa... | ['Adult', 'Auditory Perception', 'Brain Mapping', 'Cerebral Cortex', 'Female', 'Functional Laterality', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Oxygen', 'Semantics', 'Signal Detection, Psychological', 'Surveys and Questionnaires', 'Young Adult'] | 22,711,328 | [['M01.060.116'], ['F02.463.593.071', 'G07.888.125'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['D01.268.185.550', 'D01.36... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Preparing for retirement. Aspects of didactic adult education]. | The beginning of the post-professional lifetime is one of the most significant transition points in human biography. Adult education is a central institution which prepares people for important changes of their living conditions after retirement. This article gives a description of motivations for an institutional prep... | ['Adaptation, Psychological', 'Aged', 'Education, Continuing', 'Humans', 'Job Satisfaction', 'Life Change Events', 'Middle Aged', 'Motivation', 'Retirement'] | 2,763,620 | [['F01.058'], ['M01.060.116.100'], ['I02.358.212'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.784.692.425'], ['F01.829.458.410'], ['M01.060.116.630'], ['F01.658', 'F01.752.543.500.750'], ['I03.702']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Vimentin participates in microglia activation and neurotoxicity in cerebral ischemia. | Microglia are the 'immune cells' of the brain and their activation plays a vital role in the pathogenesis of many neurodegenerative diseases. Activated microglia produce high levels of pro-inflammatory factors, such as TNFá, causing neurotoxicity. Here we show that vimentin played a key role in controlling microglia ac... | ['Animals', 'Blotting, Western', 'Brain', 'Brain Ischemia', 'Cell Separation', 'Fluorescent Antibody Technique, Indirect', 'Image Processing, Computer-Assisted', 'In Situ Nick-End Labeling', 'Infarction, Middle Cerebral Artery', 'Ischemic Attack, Transient', 'Lipopolysaccharides', 'Macrophage Activation', 'Mice', 'Mice... | 22,681,613 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A08.186.211'], ['C10.228.140.300.150', 'C14.907.253.092'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['E01.370.225.500.607.512.240.310', 'E01.370.225.750.551.512.240.310', 'E05.200.500.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cotton fiber annexins: a potential role in the regulation of callose synthase. | Cotton fibers contain a characteristic set of proteins which interact with plasma membranes in a Ca(2+)-dependent manner. The association of these proteins with the membrane is correlated with a reduced level of UDP-glucose: (1-->3)-beta-glucan (callose) synthase activity. Analysis of the proteins released from membran... | ['Amino Acid Sequence', 'Annexins', 'Calcium', 'Cations, Divalent', 'Cell Membrane', 'Edetic Acid', 'Egtazic Acid', 'Glucosyltransferases', 'Gossypium', 'Membrane Proteins', 'Molecular Sequence Data', 'Plant Proteins', 'Protein Kinases', 'Schizosaccharomyces pombe Proteins'] | 8,401,609 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.157.125.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D01.248.497.300.333'], ['A11.284.149'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['D02.092.782.258.368.257', 'D02.241.081.018.269'], ['D08.811.913.400.450.460'], ['B01.650.940.800.57... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
"Alpha chain disease" protein def: internal deletion of a human immunoglobulin A1 heavy chain. | Protein Def is a human alpha chain disease protein related to alpha1 immunoglobulin heavy chain. The molecular weight of the polypeptide portion of the monomeric molecule is 29,300, which is a little greater than half of a normal alpha1 chain. The NH(2)-terminal of the polypeptide is heterogenous and, after a short seg... | ['Amino Acid Sequence', 'Chromatography, Gel', 'Electrophoresis, Paper', 'Heavy Chain Disease', 'Humans', 'Hydrolysis', 'Immunoglobulin Fragments', 'Molecular Weight', 'Pepsin A', 'Peptides', 'Subtilisins', 'Trypsin'] | 4,595,579 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.181.400.250'], ['E05.196.401.319', 'E05.301.300.236'], ['C15.378.147.780.490', 'C15.604.515.435', 'C20.683.780.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.380'], ['D12.644.541.500', 'D12.776.124.486.485.680', 'D12.776.124.790.651.680', 'D12.776.37... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas. | BACKGROUND: Intraoperative radiation therapy (IORT) is one of the methods used to deliver a large single dose to the tumor tissue while reducing the exposure of normal surrounding tissue. However, the usefulness of intraoperative electron therapy for malignant gliomas has not been established.METHODS: During the period... | ['Adult', 'Aged', 'Astrocytoma', 'Beta Particles', 'Brain Neoplasms', 'Central Nervous System Neoplasms', 'Female', 'Frontal Lobe', 'Glioblastoma', 'Glioma', 'Humans', 'Intraoperative Period', 'Male', 'Middle Aged', 'Occipital Lobe', 'Parietal Lobe', 'Postoperative Care', 'Radiotherapy Dosage', 'Survival Rate', 'Tempor... | 11,818,027 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.465.625.600.380.080', 'C04.557.470.670.380.080', 'C04.557.580.625.600.380.080'], ['G01.750.750.125'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.588.614.250', 'C10.551.240'], ['A08.186.211.200.885.287.500.270'], ['C04.557.465.625.600.380.080.335... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hormonal and Physiological Adaptations to High-Intensity Interval Training in Professional Male Canoe Polo Athletes. | This study compared the effects of 2 different high-intensity interval training (HIIT) programs in professional male canoe polo athletes. Responses of peak oxygen uptake (VO2peak), ventilatory threshold (VT), peak and mean anaerobic power output (PPO and MPO), blood volume, and hormonal adaptations to HIIT were examine... | ['Adaptation, Physiological', 'Adult', 'Anaerobic Threshold', 'Blood Volume', 'Heart Rate', 'Hemoglobins', 'Humans', 'Hydrocortisone', 'Male', 'Physical Conditioning, Human', 'Physical Exertion', 'Random Allocation', 'Ships', 'Sports', 'Testosterone', 'Young Adult'] | 26,349,044 | [['G07.025', 'G16.012.500'], ['M01.060.116'], ['G03.680.110', 'G11.427.680.134'], ['G09.188.130', 'G09.330.380.092'], ['E01.370.600.875.500', 'G09.330.380.500'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.4... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial load. | Opsonization enhances Streptococcus pneumoniae-induced human monocyte-derived macrophage (MDM) apoptosis. Both depletion of complement and immunoglobulin from opsonizing serum and blockade of the macrophages CR1, CR3, FcgammaRII, and FcgammaRIII partially decreased MDM apoptosis after S. pneumoniae phagocytosis, and th... | ['Apoptosis', 'Flow Cytometry', 'Humans', 'Macrophage Activation', 'Macrophages', 'Microscopy, Fluorescence', 'Monocytes', 'Opsonin Proteins', 'Phagocytosis', 'Pneumonia, Pneumococcal', 'Receptors, Complement', 'Receptors, IgG', 'Streptococcus pneumoniae'] | 14,551,881 | [['G04.146.954.035'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.287.500'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.52... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessment of metal pollution in Onsan Bay, Korea using Asian periwinkle Littorina brevicula as a biomonitor. | Cadmium (Cd), lead (Pb), copper (Cu) and zinc (Zn) concentrations in the marine gastropod, Littorina brevicula Philippi, were determined to assess the metal pollution in Onsan Bay, Korea. Samples of L. brevicula employed as a biomonitor and seawater were collected from 12 to 20 stations of Onsan Bay in November 1997, r... | ['Animals', 'Body Burden', 'Cadmium', 'Copper', 'Environmental Monitoring', 'Fresh Water', 'Korea', 'Lead', 'Metals, Heavy', 'Mollusca', 'Seawater', 'Water Pollutants, Chemical', 'Zinc'] | 10,507,153 | [['B01.050'], ['E05.799.638.231', 'N06.850.460.200'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G16.500.275.280', 'N06.230.232'], ['Z01.252.474.557', 'Z01.586.407'], ['D01.268.556.435', 'D01.552.544... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones. | Chymase possesses a wide variety of actions, including promotion of angiotensin II production and histamine release from mast cells. However, due to a lack of effective inhibitors featuring both high inhibitory activity and high metabolic stability, the pathophysiological role of chymase has not been fully elucidated. ... | ['Animals', 'Biological Availability', 'Cattle', 'Chymases', 'Combinatorial Chemistry Techniques', 'Humans', 'Ketones', 'Kinetics', 'Pyrimidines', 'Rats', 'Serine Endopeptidases', 'Serine Proteinase Inhibitors', 'Structure-Activity Relationship'] | 11,249,123 | [['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['B01.050.150.900.649.313.500.380.271'], ['D08.811.277.656.300.760.103', 'D08.811.277.656.959.350.103'], ['E05.197.312', 'J01.897.836.249.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.522'], ['G01.374.661', 'G02.111.490'], ['D03.383.742'], ['B01.050.150.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Sex differences in small-magnitude heart-rate responses to sexual and infant-related stimuli: a psychophysiological approach. | Small-magnitude (2-3 beats per minute) heart-rate responses can show sex differences if assessed with a psychophysiological approach in which temporally fine-grained methods are used to determine topographical differences. Such differences emerged when 15 males and 37 females were shown videosegments depicting emotiona... | ['Adult', 'Erotica', 'Female', 'Heart Rate', 'Humans', 'Infant', 'Male', 'Photic Stimulation', 'Psychophysiology', 'Sex Factors'] | 2,629,003 | [['M01.060.116'], ['K01.517.414', 'L01.178.682.441'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.723.729'], ['E02.190.525.812', 'F02.830', 'F04.096.795', 'H01.158.782.795'], ['N05.715.350.675', 'N06.850.490.875']] | ['Named Groups [M]', 'Humanities [K]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Surface electrocardiographic characteristics of right and left atrial flutter. | BACKGROUND: There is little information about the surface expression of non-cavotricuspid isthmus (CTI)-dependent right atrial (RA) or left atrial (LA) flutter circuits.METHODS AND RESULTS: We retrospectively evaluated 32 episodes (in 26 patients) of atypical RA and 22 episodes (in 21 patients) of LA flutter. The surfa... | ['Aged', 'Atrial Flutter', 'Body Surface Potential Mapping', 'Catheter Ablation', 'Electrocardiography', 'Electrophysiologic Techniques, Cardiac', 'Female', 'Heart Atria', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Sensitivity and Specificity'] | 12,835,225 | [['M01.060.116.100'], ['C14.280.067.248', 'C23.550.073.248'], ['E01.370.370.380.240.850.100', 'E01.370.405.240.850.100'], ['E02.808.750.500', 'E04.014.760.500'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E01.370.370.380.245', 'E01.370.405.267'], ['A07.541.358'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A simple and cost effective method for the quantification of 8-hydroxy-2'-deoxyguanosine from urine using liquid chromatography tandem mass spectrometry. | A rapid and high-throughput method for the determination of urinary levels of the oxidative stress biomarker, 8-hydroxy-2'-deoxyguanosine (8-OH-dG), has been developed and validated using liquid chromatography combined with electrospray ionization tandem mass spectrometry (LC-MS/MS). The assay features a cheap and read... | ["8-Hydroxy-2'-Deoxyguanosine", 'Chromatography, Liquid', 'Deoxyguanosine', 'Humans', 'Molecular Structure', 'Reproducibility of Results', 'Tandem Mass Spectrometry'] | 18,004,745 | [['D03.633.100.759.590.454.240.500', 'D13.570.230.360.500', 'D13.570.583.454.240.500'], ['E05.196.181.400'], ['D03.633.100.759.590.454.240', 'D13.570.230.360', 'D13.570.583.454.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570', 'G02.466'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', '... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Dietary vitamin E supplement does not inhibit changes in lung pressure-volume characteristics produced by bleomycin in hamsters. | We tested the hypothesis that a dietary supplement of vitamin E (VE) may lessen changes in pulmonary pressure-volume characteristics induced by intratracheal instillation of bleomycin. Ninety-nine male hamsters were separated into a control group (C), a VE supplement group (E), a control plus bleomycin group (CB) and a... | ['Animals', 'Bleomycin', 'Cricetinae', 'Diet', 'Lung Compliance', 'Lung Volume Measurements', 'Male', 'Mesocricetus', 'Pulmonary Fibrosis', 'Vitamin E'] | 2,458,962 | [['B01.050'], ['D09.400.420.110', 'D12.644.233.110'], ['B01.050.150.900.649.313.992.635.075.250'], ['G07.203.650.240'], ['E01.370.386.700.475', 'G09.772.540'], ['E01.370.386.700.485'], ['B01.050.150.900.649.313.992.635.075.250.500'], ['C08.381.765'], ['D03.383.663.283.909', 'D03.633.100.150.909']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Viscosity-dependent fluid dynamics of eyedrops on the ocular surface. | PURPOSE: To determine whether the viscosity of eyedrops affects the distribution of the precorneal tear film.METHODS: Using a differential pachymetry map, we obtained tear film thickness in healthy volunteers before and after the instillation of nonviscous, aqueous artificial tears and a 0.3% sodium hyaluronate solutio... | ['Cornea', 'Corneal Topography', 'Humans', 'Hyaluronic Acid', 'Ophthalmic Solutions', 'Tears', 'Viscosity'] | 9,512,158 | [['A09.371.060.217'], ['E01.370.380.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.698.373.475'], ['D26.776.708.645', 'D27.505.954.578.645', 'D27.720.752.608'], ['A12.200.882'], ['G02.930']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dehydration propensity of order-disorder intermediate regions in soluble proteins. | Soluble folded proteins maintain their structural integrity by properly shielding most backbone amides and carbonyls from full hydration. This structure "wrapping" entails a proper packing of the intramolecular hydrogen bonds. Thus, a poorly wrapped hydrogen bond constitutes an identifiable packing defect. Such defects... | ['Animals', 'Cell Line, Tumor', 'Cytoskeleton', 'Electrochemistry', 'Humans', 'Hydrogen Bonding', 'Protein Conformation', 'Protein Folding', 'Proteins', 'Proteomics', 'Signal Transduction', 'Solubility', 'Solvents', 'Tumor Suppressor Protein p53', 'Water'] | 17,672,484 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.214.190.750'], ['H01.181.529.307'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.282'], ['G02.111.570.820.709'], ['G01.154.651', 'G02.111.688'], ['D12.776'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.1... | ['Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Ventricular arrhythmias in patients with myocardial infarction and ischaemia. Relationship to serum potassium and magnesium. | Alterations in serum electrolytes may frequently accompany ischaemic heart disease. Many of these patients are hypertensive and receive diuretic therapy which results in chronic lowering of serum potassium and magnesium. In addition, acute catecholamine-induced shifts of potassium into cells may also occur in the setti... | ['Acute Disease', 'Angina Pectoris', 'Arrhythmias, Cardiac', 'Coronary Disease', 'Digitalis Glycosides', 'Humans', 'Magnesium', 'Myocardial Infarction', 'Potassium'] | 6,499,704 | [['C23.550.291.125'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['C14.280.067', 'C23.550.073'], ['C14.280.647.250', 'C14.907.585.250'], ['D04.210.500.155.580.130.500', 'D09.408.180.261'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'],... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biomass smoke COPD has less tomographic abnormalities but worse hypoxemia compared with tobacco COPD. | Special attention has emerged towards biomass smoke-induced chronic obstructive pulmonary disease (COPD), providing new knowledge for prevention and therapeutic approach of non-smoker COPD patients. However, the understanding of biomass smoke COPD is still limited and somewhat controversial. The aim of the present stud... | ['Aged', 'Biomass', 'Cross-Sectional Studies', 'Environmental Exposure', 'Female', 'Humans', 'Hypoxia', 'Male', 'Middle Aged', 'Pulmonary Disease, Chronic Obstructive', 'Respiratory Function Tests', 'Smoke', 'Spirometry', 'Sputum', 'Tobacco', 'Tomography, X-Ray Computed'] | 31,038,579 | [['M01.060.116.100'], ['G16.500.275.157.100', 'N06.230.124.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079'], ['M01.060.116.630'], ['C08.381.495.389'], ['E01.370.386.700'], ['D20.633.937'], ['E0... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Knowledge of correct condom use and consistency of use among adolescents in four countries in sub-Saharan Africa. | Using data from the 2004 National Adolescent Surveys, this paper undertook a detail analysis of knowledge of correct condom use and consistency of use, as well as their covariates, among adolescents in Burkina Faso, Ghana, Malawi and Uganda. The strongest predictor of knowledge of correct condom use among both male and... | ['Adolescent', 'Adolescent Behavior', 'Africa South of the Sahara', 'Condoms', 'Contraceptive Devices, Male', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Sex Education', 'Sexual Behavior', 'Young Adult'] | 18,458,741 | [['M01.060.057'], ['F01.145.022'], ['Z01.058.290'], ['E07.190.270.150'], ['E07.190.270'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.096.837.500', 'I02.233.332.749'], ['F01.145.802'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Chest pain in acute myocardial infarction among diabetic and non-diabetic patients]. | Considering that diabetic patients suffering from Acute Myocardial Infarction (AMI) may or may not have chest pain, this study aimed to compare the presence and intensity of chest pain in AMI between diabetic and non-diabetic patients. We conducted a cross-sectional study that included patients with AMI, aged ? 18 year... | ['Chest Pain', 'Cross-Sectional Studies', 'Diabetic Angiopathies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Prospective Studies', 'Severity of Illness Index'] | 22,751,712 | [['C23.888.592.612.233'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C14.907.320', 'C19.246.099.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['E05.318.372.500.750.6... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Chemical doping and electron-hole conduction asymmetry in graphene devices. | We investigate poly(ethylene imine) and diazonium salts as stable, complementary dopants on graphene. Transport in graphene devices doped with these molecules exhibits asymmetry in electron and hole conductance. The conductance of one carrier is preserved, while the conductance of the other carrier decreases. Simulatio... | ['Computer Simulation', 'Crystallization', 'Electric Conductivity', 'Electron Transport', 'Graphite', 'Macromolecular Substances', 'Materials Testing', 'Models, Chemical', 'Molecular Conformation', 'Nanostructures', 'Nanotechnology', 'Particle Size', 'Surface Properties'] | 19,102,701 | [['L01.224.160'], ['E05.196.300', 'G02.171'], ['G01.358.500.249.277'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['D01.268.150.300', 'D01.578.300'], ['D05'], ['E05.570'], ['E05.599.495'], ['G02.111.570.820'], ['J01.637.512'], ['H01.603', 'J01.897.520.600'], ['G02.712'], ['G02.860']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Accuracy of levelling intraventricular collection drainage systems. | In neuroscience critical care units, patients may have ventricular drains placed to aid management of acutely elevated intracranial pressure from a variety of causes. Correct placement of the ventricular drainage collection system, a nursing responsibility, is key to the process, and has the potential to influence pati... | ['Catheters, Indwelling', 'Critical Care', 'Drainage', 'Gravitation', 'Humans', 'Intracranial Hypertension', 'Monitoring, Physiologic', 'Ventricular Pressure', 'Ventriculostomy'] | 9,307,930 | [['E07.132.500'], ['E02.760.190', 'N02.421.585.190'], ['E02.309', 'E04.237'], ['G01.060.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.631'], ['E01.370.520'], ['G09.330.380.937', 'G09.330.955.950'], ['E04.035.188.957', 'E04.525.170.860']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Temporal dynamics of sequential motor activation in a dual-prime paradigm: Insights from conditional accuracy and hazard functions. | In response priming experiments, a participant has to respond as quickly and as accurately as possible to a target stimulus preceded by a prime. The prime and the target can either be mapped to the same response (consistent trial) or to different responses (inconsistent trial). Here, we investigate the effects of two s... | ['Humans', 'Motor Activity', 'Perceptual Masking', 'Problem Solving', 'Reaction Time'] | 32,166,642 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698'], ['F02.463.593.071.594', 'F02.463.593.932.733', 'G07.888.125.594'], ['F02.463.425.725', 'F02.463.785.810'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment of distal radius fractures with a low-profile dorsal plating system: an outcomes assessment. | PURPOSE: To evaluate objective functional and radiographic outcomes after internal fixation of acute, displaced, and unstable fractures of the distal aspect of the radius in adults by using a low-profile dorsal plating system. Our hypothesis was that the low-profile dorsal plating system would allow for a reduction of ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Bone Plates', 'Cohort Studies', 'Disability Evaluation', 'Female', 'Follow-Up Studies', 'Fracture Fixation, Internal', 'Hand Strength', 'Humans', 'Joint Instability', 'Male', 'Middle Aged', 'Pronation', 'Prosthesis Design', 'Radiography', 'Radius Fractures', 'Range of Motion, Art... | 16,516,731 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.695.370.374', 'E07.858.442.660.460.374', 'E07.858.690.725.460.374'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Predictive factors of the duration of a first-attack acute urticaria in children. | PURPOSES: This study's aim was to determine the predictive factors of the duration of first-attack acute urticaria in children.BASIC PROCEDURES: The sample included 1075 children admitted to the emergency department with first-attack acute urticaria. Variables comprising the clinical features and past histories of chil... | ['Acute Disease', 'Adolescent', 'Age Factors', 'Analysis of Variance', 'Chi-Square Distribution', 'Child', 'Child, Preschool', 'Dermatitis, Atopic', 'Emergency Service, Hospital', 'Female', 'Humans', 'Hypersensitivity', 'Infant', 'Male', 'Time Factors', 'Urticaria'] | 20,627,220 | [['C23.550.291.125'], ['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['M01.060.406'], ['M01.060.406.448'], ['C16.320.850.210', 'C17.800.174.193', 'C1... | ['Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Doctor's order: an early modern doctor's alchemical notebooks. | This is a case study on a series of at least thirty-four sixteenth-century notebooks from the Sloane collection, which reconsiders early modern notetaking techniques and the organisation of knowledge. These notebooks were written by an anonymous compiler, a physician who read widely in the alchemical and medical litera... | ['Alchemy', 'History, 16th Century', 'Manuscripts, Medical as Topic'] | 18,548,902 | [['K01.672.148'], ['K01.400.475.750'], ['L01.178.682.608.526']] | ['Humanities [K]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Column selection and method development for the determination of the enantiomeric purity of investigational non-nucleoside reverse transcriptase inhibitors. | DPC 961 and DPC 083 are investigational non-nucleoside reversed transcriptase inhibitors (NNRTI) being evaluated for the treatment of HIV infections (Corbett et al., Antimicrob Agents Chemother 1999;43:2893-2897). Both compounds are chiral and are synthesized as single enantiomers by an asymmetric synthetic pathway (Ma... | ['Anti-HIV Agents', 'Chromatography, High Pressure Liquid', 'HIV Infections', 'Humans', 'Quinazolines', 'Quinazolinones', 'Reproducibility of Results', 'Reverse Transcriptase Inhibitors', 'Stereoisomerism'] | 11,284,024 | [['D27.505.954.122.388.077.088'], ['E05.196.181.400.300'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.786'], ['D03.633.100.786.830'], ['E05.318.370.725', 'E05.337.851', 'N05.71... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Developmentally regulated rat brain mRNAs: molecular and anatomical characterization. | In order to identify markers for developing neural cell populations and gain molecular insights into the processes of neural development and differentiation, we have selected cDNA clones of rat brain mRNAs that are expressed in brain at embryonic day 16 (E16) with at least 10-fold greater abundance than they are in adu... | ['Animals', 'Brain', 'DNA', 'Electrophoresis, Agar Gel', 'Immunologic Techniques', 'Nucleic Acid Hybridization', 'Poly A', 'RNA', 'RNA, Messenger', 'Rats', 'Rats, Inbred Strains'] | 2,441,010 | [['B01.050'], ['A08.186.211'], ['D13.444.308'], ['E05.196.401.153', 'E05.301.300.100'], ['E05.478'], ['E05.393.661', 'G02.111.611'], ['D13.695.578.550.500'], ['D13.444.735'], ['D13.444.735.544'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-term follow-up after exertional heat illness during recruit training. | PURPOSE: To evaluate long-term susceptibility to subsequent serious exertional heat illness (EHI) in military recruits who suffered exertional heat illness during basic training.METHODS: We identified Marine Corps members who completed at least 6 months of military service and suffered EHI treated as outpatients (N = 8... | ['Adult', 'Case-Control Studies', 'Exercise', 'Female', 'Follow-Up Studies', 'Heat Stress Disorders', 'Hospitalization', 'Humans', 'Male', 'Military Personnel', 'Risk Factors'] | 11,528,330 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G11.427.410.698.277', 'I03.350'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C26.522'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Long-term economic outcomes associated with intensive versus moderate lipid-lowering therapy in coronary artery disease: results from the Treating to New Targets (TNT) Trial. | BACKGROUND: In 10,001 patients with stable coronary artery disease (CAD) enrolled in the Treating to New Targets (TNT) trial, 80 mg/d of atorvastatin (high-dose regimen) reduced the composite primary end point of death from CAD, nonfatal myocardial infarction, resuscitation from cardiac arrest, or stroke by 22% relativ... | ['Aged', 'Atorvastatin', 'Coronary Artery Disease', 'Female', 'Heptanoic Acids', 'Hospital Costs', 'Hospitalization', 'Humans', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Male', 'Medicare', 'Middle Aged', 'Myocardial Revascularization', 'Outcome Assessment, Health Care', 'Prospective Studies', 'Pyrroles', 'Unit... | 18,926,150 | [['M01.060.116.100'], ['D03.383.129.578.075', 'D10.251.450.200'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['D10.251.450'], ['N03.219.151.400.687', 'N03.219.262.500', 'N05.300.375.500'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.186.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Neuronal calcium activates a Rap1 and B-Raf signaling pathway via the cyclic adenosine monophosphate-dependent protein kinase. | Activity-dependent regulation of neuronal events such as cell survival and synaptic plasticity is controlled by increases in neuronal calcium levels. These actions often involve stimulation of intracellular kinase signaling pathways. For example, the mitogen-activated protein kinase, or extracellular signal-regulated k... | ['Animals', 'Calcium', 'MAP Kinase Signaling System', 'Membrane Potentials', 'Neurons', 'PC12 Cells', 'Proto-Oncogene Proteins c-raf', 'Rats', 'Signal Transduction', 'rap1 GTP-Binding Proteins'] | 10,652,372 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G02.111.820.560', 'G03.493.560', 'G04.835.560'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['A08.675', 'A11.671'], ['A11.251.210.190.750', 'A11.251.860.180.750', 'A11.299.500'], ['D08.811.913.696.620.682.700.559.842.500', 'D12.644.36... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Suicidal Behavior in Adolescents: A Latent Class Analysis. | : The main goal of the present study was to identify and validate latent classes of suicidal behavior in a representative sample of adolescents. The sample comprised a total of 1506 students, including 667 males (44.3%), selected through a sample stratified by clusters. The mean age was 16.15 years (SD = 1.36). The ins... | ['Adolescent', 'Adolescent Behavior', 'Emotions', 'Humans', 'Latent Class Analysis', 'Male', 'Risk Factors', 'Suicidal Ideation', 'Suicide', 'Suicide, Attempted'] | 32,325,865 | [['M01.060.057'], ['F01.145.022'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.250.338', 'G17.035.625', 'L01.224.050.687', 'N05.715.360.750.200.375', 'N06.850.520.830.250.338'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats. | The objective of the present study was to assess changes in cellular energy metabolism in focal and perifocal areas of a stroke lesion and to explore how these changes are modulated by preischemic hyperglycemia. A model for reversible occlusion of the middle cerebral artery (MCA) in rats was used to study changes in en... | ['Adenine Nucleotides', 'Animals', 'Arterial Occlusive Diseases', 'Blood Pressure', 'Body Temperature', 'Brain', 'Diabetes Mellitus, Experimental', 'Energy Metabolism', 'Glucose', 'Hyperglycemia', 'Lactates', 'Lactic Acid', 'Male', 'Rats', 'Rats, Inbred Strains'] | 1,727,140 | [['D03.633.100.759.646.138', 'D13.695.667.138', 'D13.695.827.068'], ['B01.050'], ['C14.907.137'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.875.374', 'G07.110'], ['A08.186.211'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['G03.295'], ['D09.947.875.359.448'], ['C18.452.394.952'], ['D02.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of multiple forms of carbonyl reductase from chicken liver. | Three enzyme forms (CR1, CR2 and CR3) of carbonyl reductase were purified from chicken liver with using 4-benzoylpyridine as a substrate. CR1 was a dimeric enzyme composed of two identical 25-kD subunits. CR2 and CR3 were monomeric enzymes whose molecular weights were both 32 kD. CR1 exhibited 17 beta-hydroxysteroid de... | ['17-Hydroxysteroid Dehydrogenases', 'Alcohol Oxidoreductases', 'Animals', 'Blotting, Western', 'Chickens', 'Chromatography, Affinity', 'Chromatography, Gel', 'Cytosol', 'Electrophoresis, Polyacrylamide Gel', 'Isoenzymes', 'Kinetics', 'Liver', 'Molecular Weight', 'Substrate Specificity'] | 1,338,044 | [['D08.811.682.047.436.375'], ['D08.811.682.047'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E05.196.181.400.170'], ['E05.196.181.400.250'], ['A11.284.430.214.200', 'A11.284.430.429.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Emergence of integron borne PER-1 mediated extended spectrum cephalosporin resistance among nosocomial isolates of Gram-negative bacilli. | BACKGROUND & OBJECTIVES: Pseudomonas extended resistant (PER) enzymes are rare type of extended-spectrum beta lactamases (ESBLs) that confer third generation cephalosporin resistance. These are often integron borne and laterally transmitted. The aim of the present study was to investigate the emergence of integron born... | ['Adolescent', 'Adult', 'Aged', 'Bacterial Proteins', 'Cephalosporins', 'Child', 'Child, Preschool', 'Drug Resistance, Bacterial', 'Escherichia coli', 'Female', 'Humans', 'India', 'Infant', 'Integrons', 'Male', 'Middle Aged', 'Plasmids', 'Pseudomonas aeruginosa', 'beta-Lactamases'] | 26,205,025 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.097'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['M01.060.406'], ['M01.060.406.448'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.9... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Defective signal transduction in CD4-CD8- T cells of lpr mice. | Mice homozygous for the lpr gene develop a lymphoproliferative disorder due to expansion of a subset of CD4-CD8- T cells. Triggering of the T-cell receptor in these lpr T cells does not lead to translocation of protein kinase C or phosphorylation of CD3, interleukin-2 production, or proliferation, whereas a combination... | ['Animals', 'Antigens, Differentiation', 'Calcium', 'Concanavalin A', 'Dose-Response Relationship, Drug', 'Inositol Phosphates', 'Lupus Erythematosus, Systemic', 'Lymph Nodes', 'Lymphocyte Activation', 'Mice', 'Mice, Mutant Strains', 'Phosphatidylinositols', 'T-Lymphocytes'] | 2,551,509 | [['B01.050'], ['D23.050.301.264', 'D23.101.100'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.503.499.500', 'D12.776.765.678.500'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.033.800.519.400', 'D09.853.519.400', 'D09.894.480'], ['C17.300.480', 'C20.111.590'], ['A10.549.400', 'A15.382.520.604.412... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MT3-MMP (MMP-16) is downregulated by in vitro cytokine stimulation of cartilage, but unaltered in naturally occurring equine osteoarthritis and osteochondrosis. | Matrix degradation by metalloproteinases is considered a key feature in the loss of articular cartilage seen in many joint diseases. Membrane-type matrix metalloproteinase-3 (MT3-MMP) expression is elevated in human cartilage in end-stage osteoarthritis. We investigated whether MT3-MMP is similarly regulated in cartila... | ['Animals', 'Cartilage, Articular', 'Cells, Cultured', 'Cytokines', 'Down-Regulation', 'Extracellular Matrix', 'Gene Expression Regulation', 'Horse Diseases', 'Horses', 'Interleukin-1beta', 'Matrix Metalloproteinase 16', 'Oncostatin M', 'Osteoarthritis', 'Osteochondritis', 'RNA, Messenger', 'Tumor Necrosis Factor-alpha... | 18,382,891 | [['B01.050'], ['A02.165.407.150', 'A02.835.583.192'], ['A11.251'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A11.284.295.310'], ['G05.308'], ['C22.488'], ['B01.050.150.900.649.313.984.235.472'], ['D12.644.276.374.465.010.600', 'D12.644.276.374.500.400.60... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of terfenadine on unilateral nasal challenge with allergen. | To investigate the role of H1 receptor-mediated effects in allergic rhinitis, we challenged 12 allergic volunteers with allergen 2 hours after administration of either placebo or 60 mg of terfenadine. Filter paper discs were used for the unilateral administration of allergen and the collection of nasal secretions. Secr... | ['Adult', 'Airway Resistance', 'Allergens', 'Double-Blind Method', 'Female', 'Histamine Release', 'Humans', 'Hypersensitivity', 'Male', 'Nasal Cavity', 'Nasal Mucosa', 'Nasal Provocation Tests', 'Sneezing', 'Terfenadine'] | 7,512,101 | [['M01.060.116'], ['E01.370.386.700.050', 'G09.772.060'], ['D23.050.063'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['G12.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543'], ['A04.531.449'], ['A04.531.520', 'A04.760.600', 'A10.615.550.760.600'], ['E01.370.38... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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