Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial KATP | CONTEXT: Cardiovascular dysfunctions such as life-threatening arrhythmias are one of the main reasons of mortality and morbidity in diabetic patients Objective: We aimed to investigate the long-term effects of resveratrol, berberine and glibenclamide combinations on the ischemia/reperfusion (I/R) induced arrhythmias in... | ['Animals', 'Arrhythmias, Cardiac', 'Berberine', 'Diabetes Mellitus, Experimental', 'Dose-Response Relationship, Drug', 'Drug Interactions', 'Glyburide', 'Heart', 'Hemodynamics', 'Male', 'Myocardial Reperfusion Injury', 'Potassium Channels, Inwardly Rectifying', 'Rats', 'Rats, Sprague-Dawley', 'Resveratrol'] | 29,457,517 | [['B01.050'], ['C14.280.067', 'C23.550.073'], ['D03.132.098.057.100', 'D03.633.400.168.100'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.968'], ['D02.065.950.828.575', 'D02.886.590.795.575'], ['A07.541'], ['G09.330.380'], ['C14.280.238.615', 'C14.280... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hearing loss with cochlear modiolar defects and large vestibular aqueducts. | OBJECTIVE: Defects of the cochlear modiolus have been found to be associated with most cases of large vestibular aqueduct. The clinical significance of these modiolar defects has not been studied previously. The purpose of this article is to correlate clinical (functional) parameters, such as hearing outcomes, with the... | ['Adolescent', 'Adult', 'Auditory Threshold', 'Child', 'Child, Preschool', 'Cochlea', 'Cognition Disorders', 'Disease Progression', 'Female', 'Follow-Up Studies', 'Hearing Loss, Conductive', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Retrospective Studies', 'Speech Reception Threshold Test', 'Vestibular Aqueduct'] | 9,596,180 | [['M01.060.057'], ['M01.060.116'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['M01.060.406'], ['M01.060.406.448'], ['A09.246.300.246'], ['F03.615.250'], ['C23.550.291.656'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C09.218.458.341.562', 'C10.5... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Predicting Depression among Patients with Diabetes Using Longitudinal Data. A Multilevel Regression Model. | INTRODUCTION: This article is part of the Focus Theme of Methods of Information in Medicine on "Big Data and Analytics in Healthcare".BACKGROUND: Depression is a common and often undiagnosed condition for patients with diabetes. It is also a condition that significantly impacts healthcare outcomes, use, and cost as wel... | ['California', 'Causality', 'Computer Simulation', 'Decision Support Systems, Clinical', 'Depression', 'Diabetes Complications', 'Electronic Health Records', 'Humans', 'Longitudinal Studies', 'Machine Learning', 'Natural Language Processing', 'Prevalence', 'Prognosis', 'Proportional Hazards Models', 'Regression Analysi... | 26,577,265 | [['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['N05.715.350.200', 'N06.850.490.625'], ['L01.224.160'], ['L01.313.500.750.300.190'], ['F01.145.126.350'], ['C19.246.099'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['B01.050... | ['Geographicals [Z]', 'Health Care [N]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Further characterization of the interaction between L-selectin and its endothelial ligands. | L-Selectin is a lectin-like receptor on lymphocytes which mediates their attachment to high endothelial venules (HEV) within lymph nodes. Previous work has identified HEV-associated endothelial ligands for L-selectin as sialylated, fucosylated and sulphated glycoproteins of approximately 50 kDa and approximately 90 kDa... | ['Animals', 'Antibodies, Monoclonal', 'Binding Sites', 'Cell Adhesion Molecules', 'Chemical Precipitation', 'Clusterin', 'Endothelium, Vascular', 'Epidermal Growth Factor', 'Glycoproteins', 'L-Selectin', 'Lewis X Antigen', 'Mannans', 'Mice', 'Molecular Chaperones', 'N-Acetylneuraminic Acid', 'Neuraminidase', 'Newcastle... | 1,384,820 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.120'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['E05.196.150', 'G02.159'], ['D12.776.395.207', 'D12.776.580.215'], ['A07.015.700.500', 'A10.272.491.355'], ['D06.472.317.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Institutions of the European Union: medical perspective. | The way through the institutions of the European Union (EU) is very difficult. The difficulties will increase with the expansion of EU to 25 member states, and even more so in the area of medical societies. Following the agenda of the EU, an efficient public health service is a responsibility of every member country. T... | ['Europe', 'European Union', 'Humans', 'International Cooperation', 'Ophthalmology', 'Public Health Administration'] | 16,193,665 | [['Z01.542'], ['I01.615.500.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615.500'], ['H02.403.810.468'], ['N04.452.794']] | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
A Phase II trial of docetaxel and cisplatin in patients with recurrent or metastatic nasopharyngeal carcinoma. | UNLABELLED: A Phase II study was conducted to determine the efficacy and toxicity of the combination of docetaxel and cisplatin, in patients with recurrent or metastatic nasopharyngeal carcinoma (NPC). Nine patients (median age 39 years) with NPC were enrolled, none had prior chemotherapy for their recurrent or metasta... | ['Adult', 'Antineoplastic Combined Chemotherapy Protocols', 'Cisplatin', 'Docetaxel', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nasopharyngeal Neoplasms', 'Neoplasm Recurrence, Local', 'Neutropenia', 'Paclitaxel', 'Taxoids', 'Treatment Outcome'] | 12,167,421 | [['M01.060.116'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D02.455.426.392.368.242.888.389', 'D02.455.849.291.850.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.443.665.710.650', 'C07.550.350.650', 'C07.550.745.65... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Extravesical antirefluxplasty (author's transl)]. | The indications and the detailed technique of extravesical antirefluxplasty are presented. Realized on 409 ureters (247 cases), extravesical antirefluxplasty has been successful in 95% of these cases. The failures, i.e., obstructions (1,5%) and persistent reflux (3%), are analized. | ['Humans', 'Methods', 'Suture Techniques', 'Ureter', 'Vesico-Ureteral Reflux'] | 327,648 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['E04.987.775'], ['A05.810.776'], ['C12.777.829.920', 'C13.351.968.829.920']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ultrasound-Guided Diagnosis of Femoral Osteomyelitis and Abscess. | Skin and soft tissue infections are common disease presentations to the pediatric emergency department, and rapid and accurate identification of potentially serious skin and soft tissue infections is critical. In cases of atraumatic musculoskeletal pain with systemic complaints, a bacterial etiology must be ruled out. ... | ['Abscess', 'Adolescent', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Osteomyelitis', 'Point-of-Care Systems', 'Staphylococcus aureus', 'Ultrasonography, Interventional'] | 26,335,234 | [['C01.830.025', 'C23.550.470.756.100'], ['M01.060.057'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C01.160.495', 'C05.116.165.495'], ['N04.452.442.452.452.680', 'N04.452.515.360.652', 'N04.590.874'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100', 'B03.510.100.750.750.100',... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Prognostic evaluation of unfavorable coronary atherosclerosis]. | The aim of the study was optimization of the evaluation of questioning data for detection of prognostically unfavorable coronary atherosclerosis (PUCA). The subjects were 124 patients (96 men; 28 women) with chest pain and coronary atherosclerosis risk factors. The patients were questioned in detail; the character of p... | ['Adult', 'Aged', 'Angina Pectoris', 'Coronary Angiography', 'Coronary Artery Bypass', 'Coronary Artery Disease', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patient Selection', 'Prognosis', 'Risk Factors', 'Severity of Illness Index', 'Surveys and Questionnaires'] | 16,502,719 | [['M01.060.116'], ['M01.060.116.100'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['C14.280.647.250.260', 'C14.907.137.126.339'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Rooming-in care of low birth weight infants]. | Two groups were compared: 50 small infants were together with their mothers upon their wish, 50 were in traditional separated units, because mothers refused rooming-in care. More primiparas and non smoking women chose the rooming-in system. In this group all of them breast fed their babies at discharge from hospital. I... | ['Breast Feeding', 'Humans', 'Hungary', 'Infant Care', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Infant, Premature', 'Infant, Small for Gestational Age', 'Rooming-in Care'] | 2,345,646 | [['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.248.495'], ['N02.421.088.120'], ['M01.060.703.520.460'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['M01.060.703.520.460.560'], ['N02.421.088.120.240']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Increased Left Atrial Appendage Density on Computerized Tomography is Associated with Cardioembolic Stroke. | BACKGROUND AND PURPOSE: While studies have stratified cardioembolic (CE) stroke risk by qualitative left atrial appendage (LAA) morphology and biomarkers of atrial dysfunction, the quantitative properties that underlie these observations are not well established. Accordingly, we hypothesized that LAA volume and contras... | ['Aged', 'Aged, 80 and over', 'Atrial Appendage', 'Databases, Factual', 'Embolism', 'Female', 'Heart Diseases', 'Hemodynamics', 'Humans', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Prognosis', 'Prospective Studies', 'Risk Assessment', 'Risk Factors', 'Stroke', 'Tomography, X-Ray Computed'] | 31,932,211 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.541.358.100'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['C14.907.355.350'], ['C14.280'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ... | ['Named Groups [M]', 'Anatomy [A]', 'Information Science [L]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Home accidents to children under 15 years: survey of 910 cases. | Out of 910 accidents sustained by children under 15 seen at the casualty department of a local hospital 678 (74.5%) were to children under 5 years of age. Boys were more prone to accidents than girls, and in preschool children the highest incidence of accidents was among the 2-to 3-year-olds of both sexes. Social class... | ['Accident Prevention', 'Accidents, Home', 'Adolescent', 'Burns', 'Child', 'Child, Preschool', 'England', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Poisoning', 'Sex Factors', 'Social Environment', 'Wounds and Injuries'] | 4,852,285 | [['N06.850.135.060'], ['N06.850.135.217'], ['M01.060.057'], ['C26.200'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C25.723'], ['N05.715.350.675', 'N06.850.490.875'], ['I01.880.853.500'], ['C26']] | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Insulin stimulates glucose metabolism via the pentose phosphate pathway in Drosophila Kc cells. | Drosophila melanogaster has become a prominent and convenient model for analysis of insulin action. However, to date very little is known regarding the effect of insulin on glucose uptake and metabolism in Drosophila. Here we show that, in contrast to effects seen in mammals, insulin did not alter [(3)H]2-deoxyglucose ... | ['6-Aminonicotinamide', 'Animals', 'Carbon Dioxide', 'Carbon Radioisotopes', 'Cell Line', 'Deoxyglucose', 'Drosophila melanogaster', 'Glucose', 'Glycogen', 'Insulin', 'Lactic Acid', 'Pentose Phosphate Pathway', 'Tritium'] | 14,644,433 | [['D03.066.515.530.248', 'D03.383.725.547.530.248'], ['B01.050'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['A11.251.210'], ['D09.254.229'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['D09.947.875.359.448'], ['D05.750.078.562.388', 'D09... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Optimization of the intracavitary irradiation of patients with cancer of the endometrium]. | Twelve variants of uterine cavity structure were defined on analysis of 52 hysterocervicograms performed in patients with cancer of the uterine body. Using the method of linear programming, the most effective schemes for the location of radiation sources were proposed to ensure optimum dose distribution in intracavitar... | ['Brachytherapy', 'Female', 'Humans', 'Programming, Linear', 'Radiotherapy Dosage', 'Uterine Neoplasms', 'Uterus'] | 3,185,204 | [['E02.815.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.906.394.748'], ['E02.815.639'], ['C04.588.945.418.948', 'C13.351.500.852.762', 'C13.351.937.418.875'], ['A05.360.319.679']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Characterization of the bovine salivary gland transcriptome associated with Mycobacterium avium subsp. paratuberculosis experimental challenge. | BACKGROUND: Mycobacterium avium subsp. paratuberculosis (MAP), the etiologic agent of Johne's disease is spread between cattle via the fecal-oral route, yet the functional changes in the salivary gland associated with infection remain uncharacterized. In this study, we hypothesized that experimental challenge with MAP ... | ['Animals', 'Cattle', 'Gene Expression Profiling', 'Gene Ontology', 'Genomics', 'Mycobacterium avium subsp. paratuberculosis', 'Salivary Glands', 'Sequence Alignment', 'Sequence Analysis'] | 31,195,975 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.393.332'], ['H01.158.273.343.249.099', 'H01.770.644.145.350.124', 'L01.224.050.375.480.500.500', 'L01.313.500.750.300.550.500.500', 'L01.453.245.945.079.500'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B03.510.024.962.500.300.600', 'B03.510.460.400.41... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Sampling studies in ambulatory quality assurance -- using the example of colonoscopy]. | BACKGROUND: Sampling inspections are an approved instrument for assuring and promoting the quality of healthcare. Individual documentations of medical services are requested from physicians and randomly selected for quality rating by experienced peer reviewers. For example, sampling inspections are stipulated by law fo... | ['Ambulatory Care', 'Colonoscopy', 'Delivery of Health Care', 'False Negative Reactions', 'False Positive Reactions', 'Humans', 'Quality Assurance, Health Care', 'Sampling Studies'] | 19,554,891 | [['E02.760.106', 'N02.421.585.106'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.250.160', 'E04.210.240.250.160', 'E04.502.250.250.250.160'], ['N04.590.374', 'N05.300'], ['E01.354.340'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.700', 'N05.700'], ['E05.318.372.875', 'N05.715.360.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth. | Somatic missense mutations in the Ser/Thr protein phosphatase 2A (PP2A) Aá scaffold subunit gene PPP2R1A are among the few genomic alterations that occur frequently in serous endometrial carcinoma (EC) and carcinosarcoma, two clinically aggressive subtypes of uterine cancer with few therapeutic options. Previous studie... | ['Animals', 'Cell Line, Tumor', 'Cell Proliferation', 'Cystadenocarcinoma, Serous', 'Endometrial Neoplasms', 'Female', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Mice', 'Mutation, Missense', 'Protein Phosphatase 2', 'Ribosomal Protein S6 Kinases, 70-kDa', 'TOR Serine-Threonine Kinases'] | 27,485,451 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.557.470.200.025.480.240', 'C04.557.470.590.480.240'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Probing the substrate specificity for lipases. II. Kinetic and modeling studies on the molecular recognition of 2-arylpropionic esters by Candida rugosa and Rhizomucor miehei lipases. | Racemic arylpropionic esters 1-3, precursors of therapeutically important non-steroidal antiinflammatory drugs, were subjected to hydrolyses in the presence of either Candida rugosa or Rhizomucor miehei crude lipases. The hydrolyses of 1 and 2 proved to be highly enantioselective, whereas 3 was not transformed at all. ... | ['Binding Sites', 'Candida', 'Crystallography, X-Ray', 'Kinetics', 'Lipase', 'Models, Molecular', 'Molecular Structure', 'Mucorales', 'Propionates', 'Protein Conformation', 'Substrate Specificity'] | 9,048,908 | [['G02.111.570.120'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['E05.196.309.742.225'], ['G01.374.661', 'G02.111.490'], ['D08.811.277.352.100.400'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['B01.300.300.500'], ['D02.241.081.751', 'D10.251.400.706'], ['G02.111.570.820.709'], ['G02.111.835']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Tuberculosis: from compulsory admission to compulsory treatment]. | Tuberculosis is still considered to be a threat to public health in the Netherlands. The Dutch Public Health Act enables the mandatory isolation of contagious patients who are not willing to be treated. However, this act does not mean that patients can be treated against their will. Another act, the Dutch Medical Treat... | ['Aged', 'Hospitalization', 'Humans', 'Mandatory Programs', 'Mental Competency', 'Middle Aged', 'Netherlands', 'Tuberculosis'] | 30,182,637 | [['M01.060.116.100'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.622', 'N03.706.657', 'N04.452.521'], ['F01.590', 'F02.410', 'I01.880.604.583.530', 'N03.706.535.625'], ['M01.060.116.630'], ['Z01.542.651'], ['C01.150.252.410.040.552.846']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Pathogenesis of recurrences of acute gastroduodenal ulcerous bleedings]. | Based on analysis of morphologic data, oxygen regime and redox potential it is demonstrated that progressive ischemic necrosis in periulcerous zone is the basis of recurrence of gastroduodenal ulcerous bleedings. Systemic hemostatic therapy, antisecretion drugs, endoscopic methods of hemostasis don't guarantee absence ... | ['Acute Disease', 'Duodenum', 'Homeostasis', 'Humans', 'Ischemia', 'Multivariate Analysis', 'Necrosis', 'Oxidative Stress', 'Peptic Ulcer Hemorrhage', 'Prognosis', 'Recurrence', 'Stomach'] | 15,159,759 | [['C23.550.291.125'], ['A03.556.124.684.124', 'A03.556.875.249'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.513'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['C23.550.717'], ['G03.673', 'G07.775.750'], ['C06.405.227.700', 'C23.550.414.788.700'], ['E01.7... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Inter-individual differences in the experience of negative emotion predict variations in functional brain architecture. | Current evidence suggests that two spatially distinct neuroanatomical networks, the dorsal attention network (DAN) and the default mode network (DMN), support externally and internally oriented cognition, respectively, and are functionally regulated by a third, frontoparietal control network (FPC). Interactions among t... | ['Adult', 'Affect', 'Anger', 'Anxiety', 'Brain', 'Brain Mapping', 'Female', 'Humans', 'Individuality', 'Magnetic Resonance Imaging', 'Male', 'Neural Pathways', 'Young Adult'] | 26,302,674 | [['M01.060.116'], ['F01.470.047'], ['F01.470.093'], ['F01.470.132'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.488'], ['E01.370.350.825.500'], ['A08.612'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Identification of a gonadotropin-releasing hormone-responsive region in the glycoprotein hormone alpha-subunit promoter. | Transcriptional regulation of the glycoprotein hormone alpha-subunit gene has been studied extensively in placental cells, but much less is known about its regulation in the pituitary gland. In this study, transcriptional control of the human alpha-subunit gene by GnRH was analyzed using transient expression assays in ... | ['8-Bromo Cyclic Adenosine Monophosphate', 'Animals', 'Gene Expression Regulation', 'Glycoprotein Hormones, alpha Subunit', 'Gonadotropin-Releasing Hormone', 'Humans', 'Pituitary Gland, Anterior', 'Promoter Regions, Genetic', 'Rats', 'Recombinant Fusion Proteins', 'Regulatory Sequences, Nucleic Acid', 'Sequence Deletio... | 1,282,668 | [['D03.633.100.759.646.138.395.225', 'D13.695.462.200.225', 'D13.695.667.138.395.225', 'D13.695.827.068.395.225'], ['B01.050'], ['G05.308'], ['D06.472.699.322.326.562', 'D06.472.699.322.576.288.750', 'D06.472.699.322.576.463.249', 'D06.472.699.631.525.343.288.750', 'D06.472.699.631.525.343.463.249', 'D06.472.699.631.52... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A study on postoperative long-term continuous immuno-chemotherapy with PSK and 5-FUDS for advanced gastric and colo-rectal cancers]. | Since 1976, postoperative long term immunochemotherapy (PLIC) with PSK and 5-FU Dry Syrup (5-FUDS) was performed after tumor resection in gastric and colorectal cancer patients. Successful continuation over one year of the therapy was done in 40 cases at stages III and IV (+V) in the period between January 1976 and Apr... | ['Aged', 'Antibiotics, Antineoplastic', 'Colonic Neoplasms', 'Drug Therapy, Combination', 'Fluorouracil', 'Humans', 'Middle Aged', 'Mitomycin', 'Mitomycins', 'Postoperative Period', 'Proteoglycans', 'Rectal Neoplasms', 'Stomach Neoplasms'] | 6,411,000 | [['M01.060.116.100'], ['D27.505.954.248.106'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['E02.319.310'], ['D03.383.742.698.875.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D02.806.400.24... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Investigating the role of mitochondrial haplogroups in genetic predisposition to meningococcal disease. | BACKGROUND AND AIMS: Meningococcal disease remains one of the most important infectious causes of death in industrialized countries. The highly diverse clinical presentation and prognosis of Neisseria meningitidis infections are the result of complex host genetics and environmental interactions. We investigated whether... | ['Chi-Square Distribution', 'Child, Preschool', 'DNA, Mitochondrial', 'Demography', 'Female', 'Genetic Predisposition to Disease', 'Genetics, Population', 'Haplotypes', 'Humans', 'Male', 'Meningococcal Infections', 'Mitochondria', 'Phylogeny'] | 20,019,817 | [['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['M01.060.406.448'], ['D13.444.308.283.225'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['C23.550.291.687.500', 'G05.380.355'], ['H01.158.273.343.335'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anatomy [A]', 'In... | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
The International Decision Support Initiative Reference Case for Economic Evaluation: An Aid to Thought. | BACKGROUND: Policymakers in high-, low-, and middle-income countries alike face challenging choices about resource allocation in health. Economic evaluation can be useful in providing decision makers with the best evidence of the anticipated benefits of new investments, as well as their expected opportunity costs-the b... | ['Capacity Building', 'Cost of Illness', 'Cost-Benefit Analysis', 'Decision Making', 'Developing Countries', 'Global Health', 'Health Policy', 'Humans', 'Uncertainty'] | 27,987,641 | [['N02.138', 'N04.452.105'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['N03.219.151.125'], ['F02.463.785.373'], ['I01.615.500.300'], ['H02.403.371', 'N01.400.337'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.... | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Label-free colorimetric detection of Hg²⁺ based on Hg²⁺-triggered exonuclease III-assisted target recycling and DNAzyme amplification. | This work reported a label-free colorimetric assay for sensitive detection of Hg(2+) based on Hg(2+)-triggered hairpin DNA probe (H-DNA) termini-binding and exonuclease ? (Exo ?)-assisted target recycling, as well as hemin/G-quadruplex (DNAzyme) signal amplification. The specific binding of free Hg(2+) with the thymine... | ['Biosensing Techniques', 'Colorimetry', 'DNA Probes', 'Exodeoxyribonucleases', 'G-Quadruplexes', 'Hydrogen Peroxide', 'Limit of Detection', 'Mercury', 'Nucleic Acid Amplification Techniques'] | 25,590,972 | [['E05.601.043'], ['E05.196.922.250'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['D08.811.277.352.335.375', 'D08.811.277.352.365.290'], ['G02.111.570.820.486.550', 'G05.360.580.550'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['E0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Status of the genus Cyrnea (Nematoda: Spiruroidea) in wild turkeys from the southeastern United States. | Two species of Cyrnea are reported from 706 wild turkeys (Meleagris gallopavo) from 25 localities in 9 southeastern states. Cyrnea (Cyrnea) neeli sp. n. in birds from Alabama and Florida is differentiated primarily by distal processes of the left spicule and spicule lengths. Specimens from wild turkeys previously repor... | ['Animals', 'Female', 'Male', 'Spiruroidea', 'Turkeys', 'United States'] | 859,088 | [['B01.050'], ['B01.050.500.500.294.400.937.700.680'], ['B01.050.150.900.248.350.800', 'B01.050.150.900.248.690.800'], ['Z01.107.567.875']] | ['Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Inversion of chromosome 3 in a case of chronic myelogenous leukemia with abnormal thrombopoiesis. | A patient with chronic myelogenous leukemia (CML) associated with a remarkable increase of micromegakaryocytes in bone marrow was revealed to have an abnormality of a long arm of chromosome #3, i.e., inv(3)(q21q26), in addition to a complex Ph translocation: t(9;22;15)(q34;q11;q22). Although several cases of acute leuk... | ['Blood Platelets', 'Chromosome Inversion', 'Chromosomes, Human, 1-3', 'Hematopoiesis', 'Humans', 'Leukemia, Myeloid', 'Male', 'Megakaryocytes', 'Middle Aged', 'Philadelphia Chromosome', 'Platelet Count'] | 3,455,854 | [['A11.118.188', 'A15.145.229.188'], ['C23.550.210.190', 'G05.365.590.175.190', 'G05.365.590.770.500', 'G05.558.805.500'], ['A11.284.187.520.300.235', 'G05.360.162.520.300.235'], ['G04.152.825', 'G09.188.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539'], ['A11.148.479', 'A15.378.316.479'], ['M... | ['Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The SV40 late protein VP4 is a viroporin that forms pores to disrupt membranes for viral release. | Nonenveloped viruses are generally released by the timely lysis of the host cell by a poorly understood process. For the nonenveloped virus SV40, virions assemble in the nucleus and then must be released from the host cell without being encapsulated by cellular membranes. This process appears to involve the well-contro... | ['Cell Membrane', 'Fluorescent Antibody Technique', 'Glutathione Transferase', 'Liposomes', 'Phosphatidylethanolamines', 'Porins', 'Porosity', 'Recombinant Fusion Proteins', 'Sequence Deletion', 'Simian virus 40', 'Viral Structural Proteins', 'Virus Release'] | 21,738,474 | [['A11.284.149'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['D08.811.913.225.500'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['D10.570.755.375.760.400.840'], ['D12.776.157.530.400.500... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cloning, expression, purification and crystallization as well as X-ray fluorescence and preliminary X-ray diffraction analyses of human ADP-ribosylhydrolase 1. | Human ADP-ribosylhydrolase 1 (hARH1, ADPRH) cleaves the glycosidic bond of ADP-ribose attached to an Arg residue of a protein. hARH1 has been cloned, expressed heterologously in Escherichia coli, purified and crystallized in complex with K(+) and ADP. The orthorhombic crystals contained one monomer per asymmetric unit,... | ['Cloning, Molecular', 'Crystallization', 'Crystallography, X-Ray', 'Enzymes', 'Fluorescence', 'Gene Expression', 'N-Glycosyl Hydrolases', 'X-Rays'] | 19,407,395 | [['E05.393.220'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D08.811'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['G05.297'], ['D08.811.277.450.430'], ['G01.358.500.505.970', 'G01.750.250.970', 'G01.750.750.918']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects on varying intravenous lipid emulsions on the small bowel epithelium in a mouse model of parenteral nutrition. | BACKGROUND: Injectable fat emulsions (FEs) are a clinically dependable source of essential fatty acids (FA). ù-6 FA is associated with an inflammatory response. Medium-chain triglycerides (MCT, ù-3 FA), fish oil, and olive oil are reported to decrease the inflammatory response. However, the effect of these lipids on th... | ['Animals', 'Cytokines', 'Dietary Fats', 'Dietary Supplements', 'Epithelial Cells', 'Fat Emulsions, Intravenous', 'Fatty Acids', 'Fatty Acids, Omega-3', 'Fatty Acids, Omega-6', 'Fish Oils', 'Inflammation', 'Intestinal Diseases', 'Intestinal Mucosa', 'Intestine, Small', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Models, Ani... | 23,757,306 | [['B01.050'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['G07.203.300.456', 'J02.500.456'], ['A11.436'], ['D26.255.165.260.270', 'D26.776.708.733.500', 'D27.505.954.578.733.500', 'D27.720.752.733.500'], ['D10.251'], ['D10.212.302.380.410', 'D10.251.355.337... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Meditation matters. | Meditation is a healing discipline that can lead to the deepest awareness of the present moment through quieting the mind. And it can have positive physical and emotional effects. | ['Attitude of Health Personnel', 'Health Promotion', 'Humans', 'Meditation', 'Nurses', 'Self Care', 'Self Concept', 'Self Psychology', 'Spirituality'] | 17,569,370 | [['F01.100.050', 'N05.300.100'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.525.374', 'E02.190.901.455', 'F04.754.137.750.500'], ['M01.526.485.650', 'N02.360.650'], ['E02.900', 'I03.050.563', 'N02.421.784.680'], ['F01.752.747.792'], ['F02.739.794.837'], ['F02.... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Extent of the tetrodotoxin induced blockade examined by pupillary paralysis elicited by intracerebral injection of the drug. | Spatial extent and duration of the functional blockade elicited by intracerebral injection of tetrodotoxin (TTX) was examined in rats anesthetized with pentobarbital. Pupillary diameter was measured under dissecting microscope before and up to 24 h after injection of TTX (10 ng/l microliters saline) into or 1.0, 1.5 an... | ['Animals', 'Brain', 'Male', 'Microinjections', 'Mydriasis', 'Oculomotor Nerve', 'Pupil', 'Rats', 'Stereotaxic Techniques', 'Tetrodotoxin'] | 2,026,211 | [['B01.050'], ['A08.186.211'], ['E02.319.267.530.690', 'E05.591.570'], ['C11.710.570'], ['A08.800.050.050.650', 'A08.800.050.600.475', 'A08.800.800.060.650', 'A08.800.800.120.600'], ['A09.371.060.450.780', 'A09.371.894.513.780'], ['B01.050.150.900.649.313.992.635.505.700'], ['E04.525.800', 'E05.873'], ['D03.633.100.786... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Training surgically competent doctors for South African rural settings. | The training of surgically competent doctors for South African rural settings is governed by several factors and determinants which include population demographics, distribution of doctors, infrastructural development and socio-economic conditions of the communities. Demands will be influenced by the disease profile, a... | ['Education, Medical, Continuing', 'Education, Medical, Graduate', 'Education, Medical, Undergraduate', 'General Surgery', 'Humans', 'Internship and Residency', 'Physician Incentive Plans', 'Physicians, Family', 'Rural Population', 'South Africa'] | 9,429,336 | [['I02.358.212.350', 'I02.358.399.250'], ['I02.358.337.350', 'I02.358.399.350'], ['I02.358.399.450'], ['H02.403.810.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['N04.452.677.740'], ['M01.526.485.810.770', 'N02.360.810.770'], ['N01.600.725'], ['Z01.058.290.175.... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Research to Support the Development of a Campaign to Increase Physical Activity Among Low-Income, Urban, Diverse, Inactive Teens. | OBJECTIVE: To ascertain inactive teens' insights regarding the types of physical activities (PAs) they would be willing to do, and to inform a Supplemental Nutrition Assistance Program-Education PA social marketing campaign targeting this audience.DESIGN: Formative, qualitative research via focus groups.SETTING: Low-in... | ['Adolescent', 'African Americans', 'Exercise', 'Focus Groups', 'Health Promotion', 'Hispanic Americans', 'Humans', 'Poverty', 'Psychology, Adolescent', 'Qualitative Research', 'Sedentary Behavior'] | 30,910,316 | [['M01.060.057'], ['M01.686.508.100.100', 'M01.686.754.100'], ['G11.427.410.698.277', 'I03.350'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['I02.233.332.445', 'N02.421.726.407.579'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.735.634', 'I01.880.853.996.535'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Angiographic management of massive hemobilia due to iatrogenic trauma. | Ten patients with massive hemobilia in shock or preshock status were treated with angiography. The hemobilia had been induced by iatrogenic trauma: biliary drainage in seven patients, and surgery, liver biopsy, and angiography in one patient each. Angiography was performed on all patients. Embolization was performed in... | ['Aged', 'Angiography', 'Bile Ducts', 'Biliary Tract Surgical Procedures', 'Embolization, Therapeutic', 'Female', 'Hemobilia', 'Hepatic Artery', 'Humans', 'Iatrogenic Disease', 'Intraoperative Complications', 'Liver', 'Male', 'Middle Aged'] | 1,879,634 | [['M01.060.116.100'], ['E01.370.350.700.060', 'E01.370.370.050'], ['A03.159.183'], ['E04.210.120'], ['E02.520.360', 'E02.926.500'], ['C23.550.414.864'], ['A07.015.114.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.291.875'], ['C23.550.505'], ['A03.620'], ['M01.060.116.630']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Histological evaluation of the effects of intraarterial chemotherapy for advanced breast cancer: a long-term followup study with respect to the survival rate. | To evaluate the effects of intraarterial infusion chemotherapy (IAIC) for advanced breast cancer, we examined the grade of histological responses of preoperative IAIC on tumors at the time of operation and estimated the patients' prognoses for 19 years. IAIC was done preoperatively using timely epochal anticancer drugs... | ['Adult', 'Antineoplastic Agents', 'Breast Neoplasms', 'Chemotherapy, Adjuvant', 'Female', 'Follow-Up Studies', 'Humans', 'Infusions, Intra-Arterial', 'Middle Aged', 'Neoplasm Staging', 'Prognosis', 'Survival Analysis'] | 9,607,903 | [['M01.060.116'], ['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['E02.186.170', 'E02.319.170'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510.520'], ['M01.060.116.630'], ['E01.789.625'], ['E01.789'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Radiosensitization by pemetrexed of human colon carcinoma cells in different cell cycle phases. | PURPOSE: The novel folate antimetabolite Alimta (pemetrexed disodium, LY231514) exhibits antitumor activity in a broad array of human malignancies and was recently found to enhance radiation-induced cell killing in vitro. In the present study, a possible cell cycle phase-specific radiosensitization by pemetrexed was as... | ['Apoptosis', 'Cell Cycle', 'Colonic Neoplasms', 'Dose-Response Relationship, Radiation', 'Glutamates', 'Guanine', 'Humans', 'Pemetrexed', 'Radiation Tolerance', 'Radiation-Sensitizing Agents', 'Tumor Cells, Cultured'] | 12,909,245 | [['G04.146.954.035'], ['G04.144'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['D12.125.067.625', 'D12.125.119.409'], ... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Free peroneal and its composite flap: a distant donor for head and neck reconstruction. | Free peroneal or its composite flap from the leg has been transferred in four patients for oro-mandibular and hypopharyngeal defects following surgery for malignancy. These flaps were successfully transplanted in all patients: two cases of free peroneal flap and two of free fibular graft with skin with no resulting pro... | ['Aged', 'Female', 'Fibula', 'Humans', 'Male', 'Mandible', 'Mandibular Neoplasms', 'Middle Aged', 'Pharyngeal Neoplasms', 'Pharynx', 'Surgical Flaps', 'Tomography, X-Ray Computed'] | 8,323,492 | [['M01.060.116.100'], ['A02.835.232.043.650.321'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['C04.588.149.721.450.583', 'C05.116.231.754.450.583', 'C05.500.499.583', 'C05.500.607.442', 'C07.320.515.583', 'C07.320.610.583'], ['M01.060.116.630'], ['C04.588.443.665.7... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effects of day-to-day variability of physiological data on operator functional state classification. | The application of pattern classification techniques to physiological data has undergone rapid expansion. Tasks as varied as the diagnosis of disease from magnetic resonance images, brain-computer interfaces for the disabled, and the decoding of brain functioning based on electrical activity have been accomplished quit... | ['Electroencephalography', 'Female', 'Humans', 'Male', 'Pattern Recognition, Automated', 'Signal Processing, Computer-Assisted', 'Task Performance and Analysis', 'User-Computer Interface', 'Workload', 'Young Adult'] | 21,840,403 | [['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.399.750'], ['L01.224.800'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600'], ['L01.224.900.910'], ['I03.946.225.500', 'N04.452.677.650.500'], ['M01.060.116.815']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Application of Calcium Silicate Materials After Acid Etching May Preserve Resin-Dentin Bonds. | INTRODUCTION: The aim of the present study was to evaluate the effect of the application of calcium silicate materials (CSMs), after acid etching, on the longevity of the hybrid layer and marginal adaptation of composite restorations.METHODS AND MATERIALS: Eighty human permanent molars received an intrapulpal pressure ... | ['Acid Etching, Dental', 'Calcium Compounds', 'Dental Bonding', 'Dental Marginal Adaptation', 'Dental Restoration, Permanent', 'Dentin', 'Humans', 'Microscopy, Electron, Scanning', 'Molar', 'Resins, Synthetic', 'Silicates'] | 29,953,337 | [['E06.931.475.111'], ['D01.146'], ['E06.095'], ['E06.323.764', 'E06.658.224', 'E06.780.620'], ['E06.323.428', 'E06.780.346.737', 'E07.695.190.190'], ['A14.549.167.900.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['A14.549.167.860.525'], ['D05.750.716.822', 'D2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cosmetic rehabilitation following successful treatment of aggressive periodontitis. | UNLABELLED: With advances in periodontal therapy, many sufferers from aggressive periodontitis are retaining their teeth after successful treatment. This presents the practitioner with aesthetic and restorative challenges in these relatively young patients. Lifelong motivation is essential to the supportive therapy for... | ['Adult', 'Aggressive Periodontitis', 'Crowns', 'Denture, Partial, Fixed', 'Esthetics, Dental', 'Female', 'Gingival Recession', 'Humans', 'Orthodontics, Corrective', 'Periodontal Prosthesis', 'Tooth Loss', 'Tooth Migration'] | 17,432,773 | [['M01.060.116'], ['C07.465.714.533.161'], ['E06.780.346.250', 'E07.695.190.088'], ['E06.780.346.760.943.271', 'E07.695.190.200.220.220'], ['E06.420'], ['C07.465.714.258.447', 'C07.465.714.354.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E06.658.578'], ['E06.721.721', 'E07.695.190.610'], ['C07.465.714.804'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of alpha 1-adrenergic blockade on pulsatile luteinizing hormone, follicle-stimulating hormone, and prolactin secretion in polycystic ovary syndrome. | Central noradrenergic mechanisms may participate in the regulation of pulsatile gonadotropin secretion in women with the polycystic ovary syndrome (PCO). To examine this possibility we measured serum LH, FSH, and PRL concentrations at 10-min intervals and total testosterone and 17 beta-estradiol at 60-min intervals for... | ['Adolescent', 'Adrenergic alpha-Antagonists', 'Adult', 'Female', 'Follicle Stimulating Hormone', 'Humans', 'Luteinizing Hormone', 'Moxisylyte', 'Polycystic Ovary Syndrome', 'Prolactin', 'Pulsatile Flow'] | 2,889,749 | [['M01.060.057'], ['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['M01.060.116'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.322.576.463', 'D06.472.699.631.525.343.463', 'D12.644.548.691.525.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The INHERIT Model: A Tool to Jointly Improve Health, Environmental Sustainability and Health Equity through Behavior and Lifestyle Change. | The need for analysis and action across the interrelated domains of human behaviors and lifestyles, environmental sustainability, health and inequality is increasingly apparent. Currently, these areas are often not considered in conjunction when developing policies or interventions, introducing the potential for subopt... | ['Conservation of Natural Resources', 'Delivery of Health Care', 'Europe', 'Health Behavior', 'Health Equity', 'Health Promotion', 'Health Status Disparities', 'Humans', 'Life Style', 'Public Health'] | 29,986,493 | [['J01.256', 'N06.230.080'], ['N04.590.374', 'N05.300'], ['Z01.542'], ['F01.145.488'], ['N04.590.374.350.500', 'N05.300.430.383'], ['I02.233.332.445', 'N02.421.726.407.579'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425.675'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458'], ['H02.403.72... | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
Altered expression of p53 and p27 proteins, alone or combined, as a predictor of metastatic potential in early invasive carcinoma of colon and rectum--a comparative clinicopathologic and molecular analysis. | To place the choice of therapy (endoscopic resection or radical surgery) in early invasive carcinoma (EIC) of colon and rectum on a more rational basis, this study sought to identify molecular predictors of metastasis. Several morphologic risk factors (histologic type, degree of tumor invasion, lymphatic and venous inv... | ['Adenocarcinoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Cell Cycle Proteins', 'Chi-Square Distribution', 'Colorectal Neoplasms', 'Cyclin-Dependent Kinase Inhibitor p27', 'Cyclin-Dependent Kinases', 'Enzyme Inhibitors', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genes, Tumor Suppressor',... | 11,059,565 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['D12.776.167'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.4... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction. | BACKGROUND: The genome of the Gram-positive, metal-reducing, dehalorespiring Desulfitobacterium hafniense DCB-2 was sequenced in order to gain insights into its metabolic capacities, adaptive physiology, and regulatory machineries, and to compare with that of Desulfitobacterium hafniense Y51, the phylogenetically close... | ['Carbon Dioxide', 'DNA, Bacterial', 'Desulfitobacterium', 'Genes, Bacterial', 'Genome, Bacterial', 'Halogens', 'Metabolic Networks and Pathways', 'Metals', 'Molecular Sequence Data', 'Nitrogen Fixation', 'Organic Chemicals', 'Oxidation-Reduction', 'Sequence Analysis, DNA'] | 22,316,246 | [['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D13.444.308.212'], ['B03.353.625.782.149', 'B03.900.174'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.360.340.358.207'], ['D01.268.380'], ['G03.493'], ['D01.552'], ['L01.453.245.667'], ['G02.111.071.630', 'G02.111.58... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Changes in prejunctional potency of B-HT 933 during aging in the rat vas deferens. | 1. Age-related changes in prejunctional alpha 2-adrenoceptors were examined in the rat vas deferens using pharmacological techniques. 2. B-HT 933 (1 x 10(-8) - 1 x 10(-6) mol/L) caused a concentration-dependent inhibition of isometric contractions (tetrodotoxin-sensitive) induced by stimulation with single field-stimul... | ['Aging', 'Animals', 'Azepines', 'Male', 'Muscle Contraction', 'Rats', 'Rats, Inbred Strains', 'Receptors, Adrenergic, alpha', 'Vas Deferens', 'Yohimbine'] | 2,170,068 | [['G07.345.124'], ['B01.050'], ['D03.383.066'], ['G11.427.494'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D12.776.543.750.670.300.300.300', 'D12.776.543.750.695.150.300.300', 'D12.776.543.750.720.330.300.300'], ['A05.360.444.930'], ['D03.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion. | The aim of this study was to define better the motor phenomena associated with the slowing of gastric emptying by a duodenal lipid infusion. Antral, pyloric and duodenal motility were recorded in 10 healthy subjects with a manometric assembly which incorporated multiple perfused side-holes and a sleeve sensor positione... | ['Adult', 'Duodenum', 'Fat Emulsions, Intravenous', 'Female', 'Food', 'Gastric Emptying', 'Gastrointestinal Motility', 'Humans', 'Hydrogen-Ion Concentration', 'Male', 'Manometry', 'Pylorus', 'Technetium Tc 99m Sulfur Colloid'] | 2,491,209 | [['M01.060.116'], ['A03.556.124.684.124', 'A03.556.875.249'], ['D26.255.165.260.270', 'D26.776.708.733.500', 'D27.505.954.578.733.500', 'D27.720.752.733.500'], ['G07.203.300', 'J02.500'], ['G10.261.360.400'], ['G10.261.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['E05.559'], ['A03.556.875.875.7... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
[Study on changes in extravascular lung water during early postoperative periods in thoracic esophageal cancer--with special emphasis on their relation to postoperative renal function]. | Twenty-seven patients with esophageal cancer received an intrathoracic esophagectomy, lymphadenectomy and esophageal reconstruction performed in one stage. They were analyzed for respiratory and hemodynamic function parameters and also observed for the time course of extravascular lung water (EVLW), water balance, rena... | ['Aged', 'Esophageal Neoplasms', 'Extravascular Lung Water', 'Female', 'Humans', 'Kidney', 'Male', 'Middle Aged', 'Postoperative Period', 'Time Factors'] | 2,348,127 | [['M01.060.116.100'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['A12.207.270.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['M01.060.116.630'], ['E04.614.750', 'N02.421.585.753.750'], ['G01.910.857']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A proteasome inhibitor confers cardioprotection. | OBJECTIVE: In several cell types, proteasome inhibitors like carbobenzoxyl-leucinyl-leucinyl-leucinal (MG132) induce the 72 kDa heat shock protein (Hsp72) and exert cell protective effects. However, data in cardiomyocytes are currently lacking.METHODS AND RESULTS: We investigated the effects of MG132 in cultured neonat... | ['Animals', 'Benzoquinones', 'Blotting, Western', 'Cells, Cultured', 'Cysteine Proteinase Inhibitors', 'Dose-Response Relationship, Drug', 'Enzyme Inhibitors', 'Fever', 'HSP72 Heat-Shock Proteins', 'Heat-Shock Proteins', 'Heme Oxygenase (Decyclizing)', 'Heme Oxygenase-1', 'Imidazoles', 'In Vitro Techniques', 'Lactams, ... | 12,062,370 | [['B01.050'], ['D02.806.250'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251'], ['D27.505.519.389.745.325'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.519.389'], ['C23.888.119.344'], ['D12.776.580.216.375.202'], ['D12.776.580.216'], ['D08.811.682.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
"There are more important things to worry about": attitudes and behaviours towards leisure noise and use of hearing protection in young adults. | OBJECTIVE: Noise-induced hearing problems among young adults are increasing due to participation in loud activities. This study explored attitudes towards leisure noise, hearing protection, and perceived susceptibility to noise damage in young adults with no diagnosed hearing problems. Understanding attitudes and behav... | ['Adolescent', 'Adult', 'Attitude to Health', 'Ear Protective Devices', 'Female', 'Focus Groups', 'Hearing Loss, Noise-Induced', 'Humans', 'Leisure Activities', 'Male', 'Noise', 'Qualitative Research', 'Young Adult'] | 29,378,448 | [['M01.060.057'], ['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['E07.700.250', 'J01.637.215.600.199', 'J01.637.708.560.250'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['C09.218.458.341.887.460', 'C10.597.751.418.341.887.460', 'C23.888.592.763.393.341.887.460'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'D... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 |
Concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF) in patients with locally advanced squamous cell carcinoma of the head and neck. | OBJECTIVE: Compared with radiotherapy alone, concurrent chemoradiotherapy significantly improves survival rates for patients with squamous cell carcinoma of the head and neck. The aim of this study was to retrospectively evaluate the efficacy, toxicity and long-term prognosis of concurrent chemoradiotherapy with doceta... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma, Squamous Cell', 'Chemoradiotherapy', 'Cisplatin', 'Disease-Free Survival', 'Docetaxel', 'Drug Administration Schedule', 'Female', 'Fluorouracil', 'Head and Neck Neoplasms', 'Humans', 'Japan', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', ... | 24,688,084 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.186.079', 'E02.319.164', 'E02.815.160'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The analysis of incomplete data in the three-period two-treatment cross-over design for clinical trials. | The additional time to complete a three-period two-treatment (3P2T) cross-over trial may cause a greater number of patient dropouts than with a two-period trial. This paper develops maximum likelihood (ML), single imputation and multiple imputation missing data analysis methods for the 3P2T cross-over designs. We use a... | ['Analysis of Variance', 'Bias', 'Clinical Trials as Topic', 'Cross-Over Studies', 'Data Interpretation, Statistical', 'Effect Modifier, Epidemiologic', 'Humans', 'Likelihood Functions', 'Reproducibility of Results'] | 8,614,750 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['N05.715.350.150', 'N06.850.490.500'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
[Long-term results of the early endoscopic treatment of acquired tracheal-subglottic stenosis: 10 years of experience]. | INTRODUCTION: Acquired stenosis of the airway is a common complication after endotracheal intubation. Endoscopic dilation has been accepted as the treatment of choice in cases detected precociously. Our goal is to know the current status of the patients treated in our hospital with endoscopic dilation in the last 10 ye... | ['Bronchoscopy', 'Child', 'Child, Preschool', 'Cohort Studies', 'Dilatation', 'Endoscopy', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Intubation, Intratracheal', 'Laryngostenosis', 'Male', 'Retrospective Studies', 'Time Factors', 'Tracheal Stenosis', 'Treatment Outcome'] | 29,419,952 | [['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.284'], ['E01.370.388.250', 'E04.502.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children. | The incidence of type 1 diabetes is rising worldwide, particularly in young children. Since type 1 diabetes is preceded by autoimmunity to islet antigens, there must be a consequent increase in the incidence of islet autoimmunity in young children or a more rapid rate of progression to diabetes once islet autoimmunity ... | ['Autoantibodies', 'Autoimmunity', 'Child', 'Diabetes Mellitus, Type 1', 'Disease Progression', 'Genetic Predisposition to Disease', 'HLA-DQ Antigens', 'HLA-DR Antigens', 'Humans', 'Incidence', 'Islets of Langerhans'] | 21,376,535 | [['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['G12.450.192'], ['M01.060.406'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C23.550.291.656'], ['C23.550.291.687.500', 'G05.380.355'], ['D12.776.395.550.509.400.430', 'D12.776.543.550.440.400.430', 'D23.050.30... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An unambiguous structural elucidation of a 1,3-beta-D-glucan obtained from liquid-cultured Grifola frondosa by solution NMR experiments. | Grifolan LE (GRN-LE), a purified beta-D-glucan, which is obtained from liquid-cultured Grifola frondosa, exhibits various biological activities, including antitumor effects. Significant progress has been made in the study of these effects. However, an unambiguous structural characterization of GRN-LE using NMR spectros... | ['Cells, Cultured', 'Glucans', 'Grifola', 'Ligands', 'Magnetic Resonance Spectroscopy', 'Solutions', 'beta-Glucans'] | 19,084,824 | [['A11.251'], ['D05.750.078.562', 'D09.698.365'], ['B01.300.179.120.372'], ['D27.720.470.480'], ['E05.196.867.519'], ['D26.776'], ['D09.698.365.089']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genotyping the hemophilia inversion hotspot by use of inverse PCR. | BACKGROUND: Factor VIII intron 22 inversions (Inv22) cause 40%-45% of severe cases of hemophilia A in all human populations. Currently, Inv22 can be analyzed either by Southern blotting or by rapid long-distance-PCR-based approaches. We describe an alternative method using inverse-PCR (I-PCR).METHODS: I-PCR involved 3 ... | ['Blotting, Southern', 'Chromosome Inversion', 'Chromosomes, Human', 'Factor VIII', 'Female', 'Genotype', 'Hemophilia A', 'Heterozygote', 'Humans', 'Introns', 'Male', 'Polymerase Chain Reaction'] | 15,860,568 | [['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['C23.550.210.190', 'G05.365.590.175.190', 'G05.365.590.770.500', 'G05.558.805.500'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['D12.776.124.125.350', 'D12.776.811.286', 'D23.119.350'], ['G05.380'], ['C15.378.100.100.500', 'C15.378.100.141.500', 'C15.378.46... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Aggressive angiomyxoma of the vulva and perineum]. | Reported in this paper are two cases of aggressive perineovulvar angiomyxoma. Soft, painless tumours with gelatinous cut surface were detected in either patient, two women aged 32 and 46 years. Histological findings included fibromyxoid stroma with spindle-shaped and stellate cells as well as vascularization in strikin... | ['Adult', 'Female', 'Humans', 'Immunohistochemistry', 'Middle Aged', 'Myxoma', 'Perineum', 'Vimentin', 'Vulvar Neoplasms'] | 1,420,111 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['M01.060.116.630... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Follicular centre cell lymphoma with alpha heavy chain disease. A histopathological and immunohistological study. | The first recorded case of a small intestinal lymphoma with alpha heavy chain disease occurring in Hungary is reported. The clinical manifestation of the disease and the focal distribution of mucosal alterations do not fulfill the criteria to make a diagnosis of Mediterranean type lymphoma (MTL) but the lymphomatous se... | ['Heavy Chain Disease', 'Humans', 'Immunoglobulin alpha-Chains', 'Intestinal Neoplasms', 'Intestine, Small', 'Lymphoma', 'Male', 'Middle Aged', 'Plasma Cells'] | 6,801,847 | [['C15.378.147.780.490', 'C15.604.515.435', 'C20.683.780.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.026.515', 'D12.776.124.486.485.705.500.350', 'D12.776.124.790.651.114.619.026.515', 'D12.776.124.790.651.705.500.350', 'D12.776.377.715.548.114.619.026.515', 'D12.776.377.715.54... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relationships of foreign protein injections (hyposensitization) in atopic children to serum lipids and lipoproteins. | Foreign protein injections (hyposensitization) given for one year to human asymptomatic asthmatics did not increase their serum total lipids or lipoprotein levels, as they apparently did in rabbits fed a lipid-rich, cholesterol-poor diet. Serum total protein and immunoglobulin levels for IgA, IgM and IgG for the asthma... | ['Adolescent', 'Adult', 'Asthma', 'Blood Proteins', 'Child', 'Child, Preschool', 'Cholesterol', 'Desensitization, Immunologic', 'Female', 'Humans', 'Immunoglobulins', 'Lipids', 'Lipoproteins', 'Lipoproteins, HDL', 'Lipoproteins, LDL', 'Lipoproteins, VLDL', 'Male', 'Parents', 'Time Factors', 'Triglycerides'] | 174,460 | [['M01.060.057'], ['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['D12.776.124'], ['M01.060.406'], ['M01.060.406.448'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['E02.095.465.425.450.310', 'E05.478.610.310'], ['B01.050.150.900.649.313.988.400... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Botulinum alignment for congenital esotropia. | This is the first report of a group of patients with congenital esotropia examined for motor and sensory evidence of binocularity a minimum of 3 years after alignment by botulinum. Evidence for binocularity was clearly present in approximately one half of the patients. Lag time to satisfactory alignment was at least 1 ... | ['Botulinum Toxins', 'Child', 'Child, Preschool', 'Depth Perception', 'Esotropia', 'Female', 'Follow-Up Studies', 'Humans', 'Injections', 'Male', 'Oculomotor Muscles', 'Sympathectomy, Chemical', 'Vision Disparity', 'Vision, Binocular', 'Visual Acuity'] | 1,494,828 | [['D08.811.277.656.300.480.153', 'D08.811.277.656.675.374.153', 'D12.776.097.156', 'D23.946.123.179'], ['M01.060.406'], ['M01.060.406.448'], ['F02.463.593.200', 'F02.463.593.778.255'], ['C10.292.562.887.300', 'C11.590.810.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Determination of toxic heavy metals in sea water by FAAS after preconcentration with a novel chelating resin. | A solid phase extraction procedure was developed for preconcentration of toxic heavy metals such as cadmium, cobalt, copper, manganese, lead and zinc in sea water samples. A microcolumn packed with 6-[(4-hydroxyphenyl)diazenyl]naphthalene-2,3-diol-formaldehyde (HPDN-F) resin acts as a sorbent to retain the analyte ions... | ['Chelating Agents', 'Hydrogen-Ion Concentration', 'Magnetic Resonance Spectroscopy', 'Metals, Heavy', 'Seawater', 'Spectrophotometry, Atomic', 'Water Pollutants, Chemical'] | 22,097,064 | [['D27.505.519.914.500', 'D27.720.832.500'], ['G02.300'], ['E05.196.867.519'], ['D01.268.556', 'D01.552.544'], ['G16.500.275.725.500'], ['E05.196.712.726.551', 'E05.196.867.826.551'], ['D27.888.284.903.655']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence of clinical rejection after surveillance biopsies in pediatric renal transplants: does early subclinical rejection predispose to subsequent rejection episodes? | We analyzed rates of both SCR and CR in children receiving SB at three months post-transplant to determine if SCR predisposed patients to acute CR. Acute rejection was defined according to Banff criteria to include borderline classification or higher. All cases of SCR and CR were treated with anti-rejection protocols. ... | ['Adolescent', 'Biopsy', 'Child', 'Child, Preschool', 'Complement C4b', 'Fibrosis', 'Follow-Up Studies', 'Graft Rejection', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Peptide Fragments', 'Prednisone', 'Tacrolimus', 'Transplantation, Homologous', 'Treatment Outcome'] | 19,515,080 | [['M01.060.057'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['M01.060.406'], ['M01.060.406.448'], ['D12.776.124.486.274.350.260'], ['C23.550.355'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A microRNA biogenesis-like pathway for producing phased small interfering RNA from a long non-coding RNA in rice. | Phased small interfering RNAs (phasiRNAs) are a class of non-coding RNAs that perform essential functions in plants. Unlike microRNA biogenesis from a hairpin structure, the production of phasiRNAs usually requires a phase initiator and an RNA-dependent RNA polymerase (RDR) to form double-strand RNAs. By using full-len... | ['MicroRNAs', 'Oryza', 'RNA, Long Noncoding', 'RNA, Plant', 'RNA, Small Interfering'] | 30,775,774 | [['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['B01.650.940.800.575.912.250.822.616'], ['D13.444.735.790.375'], ['D13.444.735.635'], ['D13.150.650.700', 'D13.444.735.150.700', 'D13.444.735.790.552.875']] | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Feasibility of a novel radiofrequency signal analysis for in-vivo plaque characterization in humans: comparison of plaque components between patients with and without acute coronary syndrome. | BACKGROUND: The iMAP™ is a novel intravascular ultrasound (IVUS)-based technology to classify coronary plaque into 4 components. The aim of this study was to evaluate the feasibility of iMAP™ technology by comparing plaque characteristics in patients with and without acute coronary syndrome (ACS and non-ACS).MATERIALS ... | ['Acute Coronary Syndrome', 'Aged', 'Aged, 80 and over', 'Coronary Artery Disease', 'Feasibility Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Percutaneous Coronary Intervention', 'Plaque, Atherosclerotic', 'Retrospective Studies', 'Ultrasonography, Interventional'] | 22,578,949 | [['C14.280.647.124', 'C14.907.585.124'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.100.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Computational modeling suggests dimerization of equine infectious anemia virus Rev is required for RNA binding. | BACKGROUND: The lentiviral Rev protein mediates nuclear export of intron-containing viral RNAs that encode structural proteins or serve as the viral genome. Following translation, HIV-1 Rev localizes to the nucleus and binds its cognate sequence, termed the Rev-responsive element (RRE), in incompletely spliced viral RN... | ['Gene Products, rev', 'Infectious Anemia Virus, Equine', 'Models, Molecular', 'Protein Binding', 'Protein Conformation', 'Protein Multimerization', 'RNA, Viral'] | 25,533,001 | [['D12.776.157.725.076', 'D12.776.664.962.186', 'D12.776.964.925.984.385'], ['B04.820.650.589.520.400'], ['E05.599.595'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709'], ['G02.111.694'], ['D13.444.735.828']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Definition, classification and epidemiology of disability]. | How can we define disability and handicap? What are their different forms? What are the figures for the persons concerned? This paper reviews the key conceptual advances and classification developments as well as new French nationwide surveys on disability. Any attempt at defining what is handicap gives rise to heated ... | ['Disability Evaluation', 'Disabled Persons', 'France', 'Humans', 'Prevalence', 'Terminology as Topic'] | 19,894,442 | [['E01.370.400'], ['M01.150'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['L01.559.598.400']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Serum vitamin D level and its relation to thyroid hormone, blood sugar and lipid profiles in Iranian sedentary work staff. | INTRODUCTION: the sedentary lifestyle is related to the incidence of various diseases and metabolic disorders. The aim of the current study was to understand the link between serum vitamin D levels, thyroid hormones and lipid profiles among Iranian sedentary staff.MATERIAL AND METHODS: in this cross-sectional study, 30... | ['Adolescent', 'Adult', 'Aged', 'Blood Glucose', 'Body Mass Index', 'Cross-Sectional Studies', 'Exercise', 'Female', 'Humans', 'Iran', 'Lipids', 'Male', 'Middle Aged', 'Nutritional Status', 'Sedentary Behavior', 'Thyroid Hormones', 'Vitamin D', 'Vitamin D Deficiency', 'Young Adult'] | 30,307,294 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D09.947.875.359.448.500'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Synthesis and biological studies of glycosyl dopamine derivatives as potential antiparkinsonian agents. | A new approach to deliver dopamine into the central nervous system, based on the use of D-glucose as transportable agent, has been studied. Glycosyl dopamine derivatives bearing the sugar moiety linked to either the amino group or the catechol ring of dopamine through amide, ester or glycosidic bonds were synthesised a... | ['Animals', 'Binding, Competitive', 'Biological Availability', 'Biological Transport', 'Blood-Brain Barrier', 'Dopamine', 'Dopamine Agents', 'Drug Stability', 'Glucose', 'Glycosides', 'Mice', 'Motor Activity', 'Parkinson Disease', 'Prodrugs', 'Rats', 'Receptors, Dopamine D2'] | 10,990,020 | [['B01.050'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['G03.787.151', 'G07.690.725.129'], ['G03.143'], ['A07.035', 'A08.186.211.035'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D27.505.519.625.150', 'D27.505.696.577.150'], ['E05.916.330'], ['D09.947.875.359.448'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anti diabetic effect of cherries in alloxan induced diabetic rats. | Diabetes mellitus (DM) is a metabolic disorder in the endocrine system resulting from a defect in insulin secretion, insulin action or both of them. Adverse side effects of chemical drugs for treatment of diabetes persuaded the using of medical plants. Cherry as a traditionally used plant for treatment of diabetes, is ... | ['Administration, Oral', 'Albuminuria', 'Alloxan', 'Animals', 'Biomarkers', 'Blood Glucose', 'Creatinine', 'Diabetes Mellitus, Experimental', 'Diabetic Nephropathies', 'Fruit', 'Hypoglycemic Agents', 'Male', 'Plant Extracts', 'Prunus', 'Rats', 'Rats, Wistar', 'Time Factors'] | 22,280,223 | [['E02.319.267.100'], ['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['D03.383.742.698.122'], ['B01.050'], ['D23.101'], ['D09.947.875.359.448.500'], ['D03.383.129.308.207'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Human T-cell leukemia virus type 1 tax dysregulates beta-catenin signaling. | Dysregulation of beta-catenin signaling has been implicated in the malignant transformation of cells. However, the role of beta-catenin in the human T-cell leukemia virus type 1 (HTLV-1)-induced transformation of T cells is unknown. Here we found that beta-catenin protein was overexpressed in the nucleus and that beta-... | ['Base Sequence', 'Cell Line', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'Cyclic AMP Response Element-Binding Protein', 'DNA', 'DNA, Viral', 'Gene Products, tax', 'Genes, pX', 'HeLa Cells', 'Human T-lymphotropic virus 1', 'Humans', 'Models, Biological', 'Phosphatidylinositol 3-Kinases', 'Proteasome Inhib... | 16,920,823 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['D12.776.260.108.184', 'D12.776.930.127.184'], ['D13.444.308'], ['D13.444.308.568'], ['D12.776.624.664.520.750.480', 'D12.776.964.700.750.480', 'D12.776.964.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Enhanced Fano resonance of organic material films deposited on arrays of asymmetric split-ring resonators (A-SRRs). | Depositing very thin organic films on the surface of arrays of asymmetric split-ring resonators (A-SRRs) produces a shift in their resonance spectra that can be utilized for sensitive analyte detection. Here we show that when poly-methyl-methacrylate (PMMA) is used as an organic probe (analyte) on top of the A-SRR arra... | ['Equipment Design', 'Equipment Failure Analysis', 'Metals', 'Polymethyl Methacrylate', 'Refractometry', 'Surface Plasmon Resonance'] | 23,609,645 | [['E05.320'], ['E05.325.192'], ['D01.552'], ['D02.241.081.069.800.550.500', 'D05.750.716.822.111.650.605.500', 'D25.720.716.822.111.650.605.500', 'J01.637.051.720.716.822.111.650.605.500'], ['E05.196.808', 'H01.671.617.755'], ['E05.196.890', 'E05.601.043.700']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Claudin-3-deficient C57BL/6J mice display intact brain barriers. | The tight junction protein claudin-3 has been identified as a transcriptional target of the Wnt/â-catenin signaling pathway regulating blood-brain barrier (BBB) maturation. In neurological disorders loss of claudin-3 immunostaining is observed at the compromised BBB and blood-cerebrospinal fluid barrier (BCSFB). Althou... | ['Animals', 'Biological Transport', 'Blood-Brain Barrier', 'Brain', 'Choroid Plexus', 'Claudin-3', 'Endothelial Cells', 'Female', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Tight Junction Proteins', 'Tight Junctions', 'Wnt Signaling Pathway'] | 30,659,216 | [['B01.050'], ['G03.143'], ['A07.035', 'A08.186.211.035'], ['A08.186.211'], ['A08.186.211.140.298'], ['D12.776.543.940.200.300'], ['A11.436.275'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['D12.776.543.940'], ['A11.284.149.165.420.8... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hydroxychloroquine in steroid dependent asthma. | A recent case report suggested that hydroxychloroquine had a steroid sparing effect in a patient with severe chronic asthma. We have studied the effect of hydroxychloroquine in a group of nine steroid dependent adult asthmatic patients using a randomised double blind crossover comparison of hydroxychloroquine and place... | ['Adult', 'Asthma', 'Beclomethasone', 'Double-Blind Method', 'Female', 'Humans', 'Hydroxychloroquine', 'Male', 'Middle Aged', 'Steroids'] | 2,980,288 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['D04.210.500.745.432.769.125', 'D04.210.500.883.154'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.810.050.180.350'], ['M0... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Distribution of [125I]nerve growth factor in the rat brain following a single intraventricular injection: correlation with the topographical distribution of trkA messenger RNA-expressing cells. | The present study determined the topographical distribution of [125I] nerve growth factor in rat brain at various time points following an intraventricular injection. In addition, we quantified the tissue content of nerve growth factor in various brain tissues following the injection. Autoradiographic analysis of the d... | ['Animals', 'Autoradiography', 'Brain', 'Cerebral Ventricles', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Gene Expression', 'In Situ Hybridization', 'Injections, Intraventricular', 'Iodine Radioisotopes', 'Kinetics', 'Nerve Growth Factors', 'Organ Specificity', 'Proto-Oncogene Proteins', 'RNA, Messenger', 'Rats', ... | 8,336,831 | [['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['A08.186.211'], ['A08.186.211.140'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G05.297'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antibody Fragments for On-Site Testing of Cannabinoids Generated via in Vitro Affinity Maturation. | Law enforcement against illicit use of cannabis and related substances requires rapid, feasible, and reliable tools for on-site testing of cannabinoids. Notably, methods based on cannabinoid-specific antibodies enable efficient screening of multiple specimens. Antibody engineering may accelerate development of modern a... | ['Amino Acid Sequence', 'Animals', 'Antibodies, Monoclonal', 'Antibody Affinity', 'Cannabinoids', 'Dose-Response Relationship, Drug', 'Female', 'Immunoglobulin Fragments', 'Mice', 'Mice, Inbred BALB C', 'Molecular Docking Simulation', 'Protein Structure, Secondary', 'Substance Abuse Detection'] | 28,154,257 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G12.040', 'G12.122.125'], ['D02.455.849.090'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.644.541.500', 'D12.776.124.486.485.680', 'D12.776.124.790.651.680', 'D12... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Academy of Nutrition and Dietetics: Revised 2012 Standards of Practice in Nutrition Care and Standards of Professional Performance for Dietetic Technicians, Registered. | DTRs face complex situations every day. Competently addressing the unique needs of each situation and applying standards appropriately is essential to providing safe, timely, person-centered quality care and service. All DTRs are advised to conduct their practice based on the most recent edition of the Academy's Code o... | ['Clinical Competence', 'Dietetics', 'Humans', 'Quality of Health Care', 'United States'] | 23,454,022 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['H02.533.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761', 'N05.715'], ['Z01.107.567.875']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Epithelial phosphatidylinositol-3-kinase signaling is required for â-catenin activation and host defense against Citrobacter rodentium infection. | Citrobacter rodentium infection of mice induces cell-mediated immune responses associated with crypt hyperplasia and epithelial â-catenin signaling. Recent data suggest that phosphatidylinositol-3-kinase (PI3K)/Akt signaling cooperates with Wnt to activate â-catenin in intestinal stem and progenitor cells through phosp... | ['Animals', 'Citrobacter rodentium', 'Colitis', 'Enterobacteriaceae Infections', 'Enzyme Activation', 'Enzyme Inhibitors', 'Enzyme-Linked Immunosorbent Assay', 'Epithelial Cells', 'Fluorescent Antibody Technique', 'Immunohistochemistry', 'Mice', 'Mice, Inbred C57BL', 'Phosphatidylinositol 3-Kinases', 'Proto-Oncogene Pr... | 21,343,355 | [['B01.050'], ['B03.440.450.425.200.737', 'B03.660.250.150.100.737'], ['C06.405.205.265', 'C06.405.469.158.188'], ['C01.150.252.400.310'], ['G02.111.263', 'G03.328'], ['D27.505.519.389'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A11.436'], ['... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Fiber-type effects of castration on the cholinergic receptor population in skeletal muscle. | The effects of castration on the extensor digitorum longus, soleus and levator ani muscles of the adult male rat were examined. After castration, no change was observed in the number of sites or the binding affinity of [125I]-monoiodo-alpha-bungarotoxin to the nicotinic cholinergic receptor population of the slow fiber... | ['Animals', 'Binding, Competitive', 'Bungarotoxins', 'Castration', 'Male', 'Muscles', 'Organ Specificity', 'Parasympathomimetics', 'Rats', 'Receptors, Cholinergic', 'Time Factors'] | 7,359,355 | [['B01.050'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D20.888.850.325.139', 'D23.946.833.850.325.139'], ['E04.270.282', 'E04.950.165'], ['A02.633', 'A10.690'], ['G07.650'], ['D27.505.696.663.050.675'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.543.750.720.360'], ['G01.910.857']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of critical thinking instruction on training complex decision making. | OBJECTIVE: Two field studies assessed the effects of critical thinking instruction on training and transfer of a complex decision-making skill.BACKGROUND: Critical thinking instruction is based on studies of how experienced decision makers approach complex problems.METHOD: Participants conducted scenario-based exercise... | ['Decision Making', 'Humans', 'Military Personnel', 'Netherlands', 'Policy Making', 'Task Performance and Analysis', 'Thinking'] | 21,141,245 | [['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.625'], ['Z01.542.651'], ['N03.706.742'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600'], ['F02.463.785']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Intrastriatal grafts from multiple donors do not result in a proportional increase in survival of dopamine neurons in nonhuman primates. | We examined the potential for "double grafts," i.e., grafts from two donors in each recipient, to enhance the total number of ventral mesencephalic dopamine neurons that survive grafting in adult African green monkeys. Because dopamine cell survival in grafts represents a small percentage of the total number of neurons... | ['Animals', 'Brain Tissue Transplantation', 'Cell Count', 'Cell Survival', 'Chlorocebus aethiops', 'Dopamine', 'Fetal Tissue Transplantation', 'Graft Rejection', 'Graft Survival', 'Humans', 'Neurons', 'Tissue Donors'] | 9,588,591 | [['B01.050'], ['E02.095.147.725.090', 'E04.525.090', 'E04.936.580.090'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.346'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['E02.095.147.725.300', ... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Patient-centred education: what do students think? | CONTEXT: Medical educators endeavour to foster patient-centred learning. Although studies of patient-educators report general increases in patient-centredness, no formal review of students' reflections on the role of patients in their education has yet been undertaken. Our research questions were: (i) What themes might... | ['Attitude of Health Personnel', 'Curriculum', 'Education, Medical', 'Female', 'Focus Groups', 'Humans', 'Male', 'Patient-Centered Care', 'Physician-Patient Relations', 'Qualitative Research', 'Role', 'Students, Medical', 'Teaching', 'Writing'] | 24,528,399 | [['F01.100.050', 'N05.300.100'], ['I02.158'], ['I02.358.399'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.727.407'], ['F01.829.401.650.675', 'N05.300.660.625'], ['H01.770.644.241.850'], ['F01.829.316.616'], ['M01.848.769.602'], ['I02... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
The influence of residents training level on their evaluation of clinical teaching faculty. | BACKGROUND: Evaluations by learners are the most common sources of information on teaching. There is some debate about the role of these assessments, but the overall evaluation of faculty by learners was found to be valid and reliable.PURPOSE: The purpose of this study was to examine the relationship between the level ... | ['Alberta', 'Cohort Studies', 'Data Collection', 'Emergency Medicine', 'Faculty', 'Internship and Residency'] | 15,691,813 | [['Z01.107.567.176.064'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['H02.403.250'], ['M01.526.702.250'], ['I02.358.337.350.500', 'I02.358.399.350.750']] | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Hepatic dysfunction following cardiac surgery: determinants and consequences. | BACKGROUND/AIMS: We prospectively studied the determinants, characteristics, and consequences of hepatic dysfunction in the early postoperative period following cardiac surgery.METHODOLOGY: We examined 3041 adult patients, mean age 60.6 (+/- 8.9), with normal pre-operative liver function who consecutively underwent ope... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Cardiac Surgical Procedures', 'Female', 'Humans', 'Jaundice', 'Liver Diseases', 'Liver Function Tests', 'Male', 'Middle Aged'] | 9,222,689 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.100.376', 'E04.928.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.429.500', 'C23.888.885.375'], ['C06.552'], ['E01.370.372.460'], ['M01.060.116.630']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
IL-6 and IL-1 beta in fever. Studies using cytokine-deficient (knockout) mice. | Previous data support the hypothesis that during inflammation, interleukin (IL)-1 beta and IL-6 are involved in fever, in activation of the hypothalamic-pituitary-adrenal (HPA) axis, and in the induction of eicosanoids. Most of the pathophysiologic effects of IL-1 beta and Il-6 are mediated by prostaglandins (PGs), mod... | ['Animals', 'Chimera', 'Dinoprostone', 'Escherichia coli', 'Female', 'Fever', 'Inflammation', 'Interleukin-1', 'Interleukin-6', 'Lipopolysaccharides', 'Male', 'Mice', 'Mice, Knockout', 'Time Factors', 'Tumor Necrosis Factor-alpha', 'Turpentine'] | 9,917,862 | [['B01.050'], ['B05.200'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C23.888.119.344'], ['C23.550.470'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.465.131', 'D2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Programs for the detection of gynecologic cancer]. | The author reviews the problem of the early detection of breast cancer in women. He tells about the etiopathogenic complex, and the risk factors in relation to breast cancer, and indicates the protocol followed for breast cancer early detection. The usefulness of the employed method is supported by the obtained results... | ['Breast Diseases', 'Breast Neoplasms', 'Diagnosis, Differential', 'Female', 'Humans', 'Mammography', 'Mass Screening', 'National Health Programs', 'Palpation', 'Risk', 'Spain', 'Thermography'] | 6,546,175 | [['C17.800.090'], ['C04.588.180', 'C17.800.090.500'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700.500'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['N03.349.550'], ['E01.370.600.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Therapeutic value of scapular and pelvic girdle disarticulations in sarcoma. | The authors have reviewed 22 cases of proximal disarticulations with the aim of assessing the therapeutic value, taking into account previous radio- and chemotherapy. The following criteria were especially examined: recurrences, survival, quality of life. There were 13/22 soft tissue sarcomas, 9/22 bone sarcomas. In 10... | ['Bone Neoplasms', 'Disarticulation', 'Evaluation Studies as Topic', 'Hemipelvectomy', 'Hip Joint', 'Humans', 'Sarcoma', 'Shoulder Joint', 'Soft Tissue Neoplasms'] | 3,595,886 | [['C04.588.149', 'C05.116.231'], ['E04.555.080.250'], ['E05.337', 'N05.715.360.335'], ['E04.555.080.380'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.795'], ['A02.835.583.748'], ['C04.588.839']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
MicroRNA loci support conspecificity of Gyrodactylus salaris and Gyrodactylus thymalli (Platyhelminthes: Monogenea). | The monogenean flatworm Gyrodactylus salaris is a serious threat to wild and farmed Atlantic salmon stocks in Norway. Morphologically, the closely related but harmless Gyrodactylus thymalli on grayling can hardly be distinguished from G. salaris. Until now, molecular approaches could not resolve unambiguously whether G... | ['Animal Distribution', 'Animals', 'Genetic Variation', 'MicroRNAs', 'Molecular Sequence Data', 'Phylogeny', 'Polymerase Chain Reaction', 'RNA, Helminth', 'Species Specificity', 'Trematoda'] | 24,998,346 | [['F01.145.113.069', 'G16.049'], ['B01.050'], ['G05.365'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.620.500'], ['D13.444.735.520'], ['G16.824'], ['B01.050.500.500.736.715']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Soil organic carbon and total nitrogen stocks in alpine ecosystems of Altun Mountain National Nature Reserve in dry China. | The Altun Mountain National Nature Reserve (AMNNR), characterized by complex topography, is located on the northern edge of the Qinghai-Tibetan Plateau. The stocks of soil organic carbon (SOC) and total nitrogen (TN) are critically important for carbon and nitrogen sequestration in dry alpine ecosystems of the AMNNR, w... | ['Carbon', 'China', 'Conservation of Natural Resources', 'Ecosystem', 'Environmental Monitoring', 'Nitrogen', 'Plants', 'Soil'] | 30,593,592 | [['D01.268.150'], ['Z01.252.474.164'], ['J01.256', 'N06.230.080'], ['G16.500.275.157', 'N06.230.124'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D01.268.604', 'D01.362.625'], ['B01.650'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600']] | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Identification of novel immunogenic proteins of Helicobacter pylori by proteome technology. | Cell surface proteins of the human gastric pathogen Helicobacter pylori, reference strain CCUG 17874, were extracted with acid glycine and fractionated by heparin affinity chromatography. The extracts were subsequently analysed using high-resolution two-dimensional gel electrophoresis (2-DE) and immunoblotting. Four pr... | ['Antigens, Bacterial', 'Bacterial Outer Membrane Proteins', 'Cross Reactions', 'Electrophoresis, Gel, Two-Dimensional', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Immunoblotting', 'Proteome', 'Serologic Tests'] | 11,730,836 | [['D23.050.161'], ['D12.776.097.120', 'D12.776.543.100'], ['G12.122.281'], ['E05.196.401.250', 'E05.301.300.230'], ['C01.150.252.400.466'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320'], ['D12.776.817'], ['E01.370.225.812.735'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Intraabdominal metastasis of cerebellar medulloblastoma through ventriculoperitoneal shunt]. | We present a 6-year-old girl with cerebellar medulloblastoma causing obstructive hydrocephalus that was treated by ventriculoperitoneal shunting. The patient subsequently underwent surgical excision of the tumor followed by adjuvant craniospinal radiotherapy. Nine months after shunting, multiple intraabdominal metastat... | ['Abdominal Neoplasms', 'Cerebellar Neoplasms', 'Child', 'Female', 'Humans', 'Medulloblastoma', 'Neoplasm Seeding', 'Ventriculoperitoneal Shunt'] | 11,181,202 | [['C04.588.033'], ['C04.588.614.250.195.411.211', 'C10.228.140.211.500.200', 'C10.228.140.252.200', 'C10.551.240.250.400.300'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.600.380.515', 'C04.557.465.625.600.590.500', 'C04.557.470.670.380.515', 'C04.557.470.670.590.500', 'C04.557.... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21. | The discs-large family is a collection of proteins that have a common structural organization and are thought to be involved in signal transduction and mediating protein-protein interactions at the cytoplasmic surface of the cell membrane. The defining member of this group of proteins is the gene product of the Drosoph... | ['Amino Acid Sequence', 'Base Sequence', 'Chromosomes, Human, Pair 17', 'DNA, Complementary', 'Genome, Human', 'Humans', 'Insect Proteins', 'Molecular Sequence Data', 'Sequence Homology, Amino Acid', 'Tissue Distribution'] | 8,824,795 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.284.187.520.300.415.425', 'G05.360.162.520.300.415.425'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model. | BACKGROUND AND PURPOSE: Female, compared with male, animals are protected from cerebral ischemic injury. Physiological concentrations of 17beta-estradiol (E2) reduce damage in experimental stroke. E2 augments angiogenesis in reproductive organs and noncerebral vascular beds. We hypothesized that E2 protects brain in st... | ['Angiopoietin-1', 'Animals', 'Brain', 'Capillaries', 'Disease Models, Animal', 'Estradiol', 'Estrogen Receptor alpha', 'Female', 'Gene Expression Regulation', 'Infarction, Middle Cerebral Artery', 'Mice', 'Mice, Knockout', 'Neovascularization, Pathologic', 'Placebos', 'Platelet Endothelial Cell Adhesion Molecule-1', '... | 15,637,314 | [['D12.644.276.100.100.100', 'D12.776.467.100.100.100', 'D23.529.100.100.100'], ['B01.050'], ['A08.186.211'], ['A07.015.461.165'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D12.776.826.750.350.174'], ['G05.308'], ['C10.228.140.300.150.477.200.450', 'C10.228... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A phase transition in energy-filtered RNA secondary structures. | In this article we study the effect of energy parameters on minimum free energy (mfe) RNA secondary structures. Employing a simplified combinatorial energy model that is only dependent on the diagram representation and is not sequence-specific, we prove the following dichotomy result. Mfe structures derived via the Tur... | ['Nucleic Acid Conformation', 'RNA', 'Sequence Analysis, RNA'] | 23,057,821 | [['G02.111.570.820.486', 'G05.360.580'], ['D13.444.735'], ['E05.393.760.710']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
From plan to action. | A strategic plan is your organizational touchstone Given the rapid rate of change in health care, your practice's capacity to succeed is based on its ability to adapt quickly; this, in turn, relies on the level of detail in the operational plan. A well-devised and detailed plan will enable your practice to navigate the... | ['Organizational Objectives', 'Planning Techniques', 'Practice Management, Medical', 'United States'] | 16,900,904 | [['N04.452.615'], ['N04.452.718'], ['N04.452.758.708.450'], ['Z01.107.567.875']] | ['Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Determination of myeloperoxidase-induced apoAI-apoAII heterodimers in high-density lipoprotein. | Myeloperoxidase secreted by macrophages and neutrophils in atherosclerotic lesions generates a tyrosyl radical in apolipoprotein (apo) AI, a major protein component of high-density lipoprotein (HDL), thus inducing the formation of apoAI-apoAII heterodimers. It can also cause nitration and chlorination of tyrosine resid... | ['Apolipoprotein A-I', 'Apolipoprotein A-II', 'Atherosclerosis', 'Chromatography, High Pressure Liquid', 'Dimerization', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Immunoblotting', 'Lipoproteins, HDL', 'Myocardial Infarction', 'Peroxidase'] | 23,090,734 | [['D10.532.091.200.100', 'D12.776.070.400.200.100', 'D12.776.521.120.200.100'], ['D10.532.091.200.150', 'D12.776.070.400.200.150', 'D12.776.521.120.200.150'], ['C14.907.137.126.307'], ['E05.196.181.400.300'], ['G02.206', 'G03.230'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines. | The canonical Wnt signalling pathway acts by slowing the rate of ubiquitin-mediated beta-catenin degradation. This results in the accumulation and subsequent nuclear translocation of beta-catenin, which induces the expression of a number of genes involved in growth, differentiation and metabolism. The mechanisms regula... | ['Animals', 'Axin Protein', 'Carcinoma, Hepatocellular', 'Cell Line, Tumor', 'Cyclin D1', 'Cytoskeletal Proteins', 'DNA Primers', 'Gene Expression Regulation, Neoplastic', 'Glucose', 'Homeostasis', 'Humans', 'Liver Neoplasms', 'Macrophages', 'Mice', 'RNA', 'Wnt Proteins', 'beta Catenin'] | 18,823,284 | [['B01.050'], ['D05.500.117.500', 'D12.776.476.081.500'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.664.700.100'], ['D12.776.220'], ['D13... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of augmented sensory feedback to achieve symmetrical standing. | Ambulatory patients with hemiparesis were given auditory feedback of weight bearing on the involved leg in order to achieve symmetrical standing. A device for augmented sensory feedback, the Limb Load Monitor, was used for the training. Patients who could correct their limb loading pattern during the first treatment se... | ['Adult', 'Aged', 'Biofeedback, Psychology', 'Female', 'Follow-Up Studies', 'Hemiplegia', 'Humans', 'Male', 'Middle Aged', 'Posture', 'Sound'] | 643,934 | [['M01.060.116'], ['M01.060.116.100'], ['E02.190.525.123', 'F02.830.131', 'F04.754.137.301', 'F04.754.308.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C10.597.622.295', 'C23.888.592.636.312'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Residue-level prediction of DNA-binding sites and its application on DNA-binding protein predictions. | Protein-DNA interactions are crucial to many cellular activities such as expression-control and DNA-repair. These interactions between amino acids and nucleotides are highly specific and any aberrance at the binding site can render the interaction completely incompetent. In this study, we have three aims focusing on DN... | ['Amino Acids', 'Artificial Intelligence', 'Binding Sites', 'DNA', 'DNA-Binding Proteins', 'Macromolecular Substances', 'Models, Biological', 'Models, Molecular', 'Protein Binding'] | 17,316,627 | [['D12.125'], ['G17.035.250', 'L01.224.050.375'], ['G02.111.570.120'], ['D13.444.308'], ['D12.776.260'], ['D05'], ['E05.599.395'], ['E05.599.595'], ['G02.111.679', 'G03.808']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42. | We previously reported that Gbetagamma signaling regulates cell spreading or cell shape change through activation of a Rho family small GTPase, suggesting the existence of a Gbetagamma-regulated Rho guanine-nucleotide exchange factor (RhoGEF). In this study we examined various RhoGEF clones, found FLJ00018 to beaGbetag... | ['Animals', 'Carbachol', 'Cell Shape', 'Cholinergic Agonists', 'Enzyme Activation', 'Gene Expression', 'Guanine Nucleotide Exchange Factors', 'Heterotrimeric GTP-Binding Proteins', 'Humans', 'Lysophospholipids', 'Mice', 'NIH 3T3 Cells', 'Neuropeptides', 'Pertussis Toxin', 'Receptor, Muscarinic M2', 'Serum Response Elem... | 18,045,877 | [['B01.050'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['G04.320'], ['D27.505.519.625.120.140', 'D27.505.696.577.120.140'], ['G02.111.263', 'G03.328'], ['G05.297'], ['D12.644.360.325.300', 'D12.776.476.325.300'], ['D08.811.277.040.330.300.200', 'D12.644.360.360', 'D12.776.157.325.332', 'D12.776.476.375', 'D1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.