Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SCFAs strongly stimulate PYY production in human enteroendocrine cells. | Peptide-YY (PYY) and Glucagon-Like Peptide-1 (GLP-1) play important roles in the regulation of food intake and insulin secretion, and are of translational interest in the field of obesity and diabetes. PYY production is highest in enteroendocrine cells located in the distal intestine, mirroring the sites where high con... | ['Cell Line', 'Cells, Cultured', 'Enteroendocrine Cells', 'Fatty Acids, Volatile', 'Gene Expression', 'Glucagon-Like Peptide 1', 'Humans', 'Peptide YY'] | 29,311,617 | [['A11.251.210'], ['A11.251'], ['A06.390', 'A11.382.625', 'A11.436.294'], ['D10.251.400'], ['G05.297'], ['D06.472.317.680.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.317.662', 'D06.472.699.595', 'D12.644.548.595']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Brain aromatase (Cyp19A2) and estrogen receptors, in larvae and adult pejerrey fish Odontesthes bonariensis: Neuroanatomical and functional relations. | Although estrogens exert many functions on vertebrate brains, there is little information on the relationship between brain aromatase and estrogen receptors. Here, we report the cloning and characterization of two estrogen receptors, alpha and beta, in pejerrey. Both receptors' mRNAs largely overlap and were predominan... | ['Amino Acid Sequence', 'Animals', 'Aromatase', 'Base Sequence', 'Brain', 'Cloning, Molecular', 'Estradiol', 'Female', 'In Situ Hybridization', 'Male', 'Molecular Sequence Data', 'Perciformes', 'Phylogeny', 'RNA, Messenger', 'Receptors, Estrogen', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sequence Alignment'] | 18,691,594 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D08.244.453.489.500', 'D08.244.453.915.099', 'D08.811.682.690.708.170.447.500', 'D08.811.682.690.708.170.915.099', 'D12.776.422.220.453.489.500', 'D12.776.422.220.453.915.099'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A08.186.211'], ['E05.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Use of antidiabetic drugs in the U.S., 2003-2012. | OBJECTIVE: To describe market trends for antidiabetic drugs, focusing on newly approved drugs, concomitant use of antidiabetic drugs, and effects of safety concerns and access restrictions on thiazolidinedione use.RESEARCH DESIGN AND METHODS: Nationally projected data on antidiabetic prescriptions for adults dispensed ... | ['Adult', 'Diabetes Mellitus, Type 2', 'Dipeptidyl-Peptidase IV Inhibitors', 'Drug Prescriptions', 'Drug Therapy, Combination', 'Glucagon-Like Peptide 1', 'Humans', 'Hypoglycemic Agents', 'Marketing of Health Services', 'Metformin', 'Pharmacies', 'Prescription Drugs', 'Pyrazines', 'Rosiglitazone', 'Sitagliptin Phosphat... | 24,623,020 | [['M01.060.116'], ['C18.452.394.750.149', 'C19.246.300'], ['D27.505.519.389.745.335', 'D27.505.696.422.500'], ['E02.319.307', 'N02.421.668.778.500'], ['E02.319.310'], ['D06.472.317.680.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['J01.219.687.550', 'N03.219.463.548', 'N05.300.430.50... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Resurgent bacterial sexually transmitted disease among men who have sex with men--King County, Washington, 1997-1999. | During the late 1980s and early 1990s, King County, Washington (1998 population: 1.6 million), experienced a substantial epidemic of infectious syphilis (i.e., primary, secondary, and early latent). Subsequently, reported cases of infectious syphilis declined to six cases in 1995 and one in 1996; five of the 1995 cases... | ['Adult', 'Homosexuality, Male', 'Humans', 'Male', 'Middle Aged', 'Sexually Transmitted Diseases, Bacterial', 'Washington'] | 11,263,546 | [['M01.060.116'], ['F01.145.802.975.500.600', 'G08.686.867.500.600'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C01.150.252.734', 'C01.221.812.281', 'C01.778.281', 'C12.294.668.281', 'C13.351.500.711.281', 'C23.550.291.531.937.281'], ['Z01.107.567.875.560.900', 'Z01.107.567.875.580.900']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Elicited and pre-existing anti-Neu5Gc antibodies differentially affect human endothelial cells transcriptome. | Humans cannot synthesize N-glycolylneuraminic acid (Neu5Gc) but dietary Neu5Gc can be absorbed and deposited on endothelial cells (ECs) and diet-induced anti-Neu5Gc antibodies (Abs) develop early in human life. While the interaction of Neu5Gc and diet-induced anti-Neu5Gc Abs occurs in all normal individuals, endotheliu... | ['Animals', 'Antibodies', 'Endothelial Cells', 'Endothelium', 'Humans', 'Immunoglobulin G', 'Transcriptome', 'Transplantation, Heterologous'] | 31,293,002 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['A11.436.275'], ['A10.272.491'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['G02.111.873.750', 'G05.297.700.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A clinical trial of the effects of estrogen in acutely psychotic women. | This study was a preliminary open clinical trial aimed at exploring the hypothesis that estrogen may provide protection against schizophrenia in women. Eleven women with acute psychotic symptoms, as scored on the BPRS, SAPS and SANS, had 0.02 mg estradiol added to neuroleptic treatment for eight weeks. Their response w... | ['Acute Disease', 'Adult', 'Antipsychotic Agents', 'Drug Therapy, Combination', 'Ethinyl Estradiol', 'Female', 'Humans', 'Pilot Projects', 'Psychiatric Status Rating Scales', 'Schizophrenia', 'Schizophrenic Psychology', 'Treatment Outcome'] | 8,827,850 | [['C23.550.291.125'], ['M01.060.116'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['E02.319.310'], ['D04.210.500.668.651.568.291', 'D06.472.334.851.437.968.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Death certification in general practice: review of records. | The records of death that had been certified by general practitioners in one practice over 18 years were assessed in the light of the recent joint publications of the Royal College of Physicians and the Royal College of Pathologists. Over this period roughly 30% of the deaths in the practice population occurred outside... | ['Adult', 'Age Factors', 'Aged', 'Death Certificates', 'England', 'Family Practice', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Middle Aged', 'Sex Factors'] | 6,424,761 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E05.318.308.940.350', 'L01.399.250.900.350', 'N04.452.859.264', 'N05.715.360.300.715.315', 'N06.850.520.308.940.350'], ['Z01.542.363.300'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.70... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Life on the rocks: habitat use drives morphological and performance evolution in lizards. | As a group, lizards occupy a vast array of habitats worldwide, yet there remain relatively few cases where habitat use (ecology), morphology, and thus, performance, are clearly related. The best known examples include: increased limb length in response to increased arboreal perch diameter in anoles and increased limb l... | ['Adaptation, Physiological', 'Animals', 'Australia', 'Biological Evolution', 'Ecosystem', 'Extremities', 'Female', 'Lizards', 'Locomotion', 'Male', 'Selection, Genetic', 'Species Specificity'] | 19,137,951 | [['G07.025', 'G16.012.500'], ['B01.050'], ['Z01.639.100', 'Z01.678.100.373'], ['G05.045', 'G16.075'], ['G16.500.275.157', 'N06.230.124'], ['A01.378'], ['B01.050.150.900.833.393'], ['G07.568.500', 'G11.427.410.568'], ['G05.783'], ['G16.824']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[Endothelium protective effect of the high viscosity substances hyaluronic acid and methylcellulose in mechanical damage]. | We investigated the protective effect of the high-viscosity substances sodium hyaluronate (1%) and methylcellulose (2%) on corneal endothelium in the face of severe mechanical insult. An intraocular lens was drawn across the endothelium of porcine corneas with standardized conditions. We used different compression forc... | ['Animals', 'Cataract Extraction', 'Endothelium, Corneal', 'Hyaluronic Acid', 'Methylcellulose', 'Swine'] | 2,272,577 | [['B01.050'], ['E04.540.825.249'], ['A09.371.060.067.318', 'A09.371.060.217.318', 'A10.272.491.318'], ['D09.698.373.475'], ['D09.698.365.180.663'], ['B01.050.150.900.649.313.500.880']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
NFAT and CREB regulate Kaposi's sarcoma-associated herpesvirus-induced cyclooxygenase 2 (COX-2). | COX-2 has been implicated in Kaposi's sarcoma-associated herpesvirus (KSHV) latency and pathogenesis (A. George Paul, N. Sharma-Walia, N. Kerur, C. White, and B. Chandran, Cancer Res. 70:3697-3708, 2010; P. P. Naranatt, H. H. Krishnan, S. R. Svojanovsky, C. Bloomer, S. Mathur, and B. Chandran, Cancer Res. 64:72-84, 200... | ['Blotting, Western', 'Cell Nucleus', 'Cells, Cultured', 'Cyclic AMP Response Element-Binding Protein', 'Cyclic AMP-Dependent Protein Kinases', 'Cyclooxygenase 2', 'DNA, Viral', 'Dermis', 'Dinoprostone', 'Electrophoretic Mobility Shift Assay', 'Endothelium, Vascular', 'Enzyme-Linked Immunosorbent Assay', 'Fibroblasts',... | 20,943,963 | [['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.251'], ['D12.776.260.108.184', 'D12.776.930.127.184'], ['D08.811.913.696.620.682.700.150.125', 'D12.644.360.200.125', 'D12.776.476.200.125'], ['D08.811.600.720.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Maximum-Entropy Models of Sequenced Immune Repertoires Predict Antigen-Antibody Affinity. | The immune system has developed a number of distinct complex mechanisms to shape and control the antibody repertoire. One of these mechanisms, the affinity maturation process, works in an evolutionary-like fashion: after binding to a foreign molecule, the antibody-producing B-cells exhibit a high-frequency mutation rat... | ['Antibodies, Neutralizing', 'Antibody Affinity', 'Antigen-Antibody Reactions', 'B-Lymphocytes', 'Binding Sites, Antibody', 'Cluster Analysis', 'Computational Biology', 'Computer Simulation', 'Entropy', 'Evolution, Molecular', 'HIV Antibodies', 'HIV Infections', 'HIV-1', 'Humans', 'Models, Immunological', 'Models, Mole... | 27,074,145 | [['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['G12.040', 'G12.122.125'], ['G12.122'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.23... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[Clinical, psychological and psychosocial factors in spontaneous and recurrent or habitual abortion. Results of a pilot study]. | In a pilotstudy about medical, psychological and psychosocial factors in spontaneous and recurrent spontaneous abortions 47 women were investigated. 26 of them had one, 14 tow and 7 three or more recurrent spontaneous abortions. Etiologic factors were unknown in about 90% of the cases. Illnesses observed were allergies... | ['Abortion, Habitual', 'Abortion, Spontaneous', 'Adult', 'Affective Symptoms', 'Endocrine System Diseases', 'Female', 'Humans', 'Hypersensitivity', 'Personality Inventory', 'Pilot Projects', 'Pregnancy', 'Psychosocial Deprivation', 'Stress, Psychological'] | 3,223,117 | [['C13.703.039.089'], ['C13.703.039', 'G08.686.784.769.496.125'], ['M01.060.116'], ['F01.145.126.100'], ['C19'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543'], ['F04.711.647.513'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['G08.686.784.769'], ['F01.829.628', 'I01.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Analysis of causes of death and YPLL on residents in the industrial pollution area in Chongqing from 1991 to 1998]. | OBJECTIVE: To investigate the causes of death in residents living in the area of industrial pollution in Chongqing.METHODS: Mortality rate, sequence of causes of death, years of potential life lost (YPLL) and the valued years of potential life lost (VYPLL) were used to analyze causes of death in 1991 - 1998. Community ... | ['Accidents', 'Cause of Death', 'Cerebrovascular Disorders', 'China', 'Environmental Pollution', 'Heart Diseases', 'Humans', 'Industry', 'Life Expectancy', 'Neoplasms', 'Residence Characteristics', 'Respiratory Tract Diseases'] | 11,860,846 | [['N06.850.135'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['C10.228.140.300', 'C14.907.253'], ['Z01.252.474.164'], ['N06.850.460'], ['C14.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.576'], ['E05.318.308.985.450', 'N01.224.935.46... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Exosomes derived from gastric cancer cells activate NF-êB pathway in macrophages to promote cancer progression. | Exosomes are nano-sized membrane vesicles secreted by both normal and cancer cells. Emerging evidence indicates that cancer cells derived exosomes contribute to cancer progression through the modulation of tumor microenvironment. However, the effects of exosomes derived from gastric cancer cells on macrophages are not ... | ['Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Disease Progression', 'Exosomes', 'Humans', 'Macrophages', 'NF-kappa B', 'Neoplasm Invasiveness', 'Signal Transduction', 'Stomach Neoplasms', 'Tumor Microenvironment'] | 27,220,495 | [['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C23.550.291.656'], ['A11.284.295.588.750', 'A11.284.430.214.190.875.190.880.495'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid and sensitive detection of Singapore grouper iridovirus by loop-mediated isothermal amplification. | AIMS: The aim of this paper was to develop a loop-mediated isothermal amplification (LAMP) method for rapid, sensitive and inexpensive detection of Singapore grouper iridovirus (SGIV) in grouper (GP), Epinephelus sp.METHODS AND RESULTS: A set of six specific primers was designed by targeting the SGIV ORF-014L. With Bst... | ['Animals', 'Base Sequence', 'DNA Primers', 'DNA, Viral', 'Fishes', 'Food Microbiology', 'Iridovirus', 'Molecular Sequence Data', 'Nucleic Acid Amplification Techniques', 'Polymerase Chain Reaction', 'Virology'] | 18,312,563 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.568'], ['B01.050.150.900.493'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300', 'N06.850.425.200', 'N06.850.460.400.300', 'N06.850.601.500.249.300'], ['B04.28... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders. | Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) path... | ['Adult', 'Aged', 'Biomarkers', 'Brain-Derived Neurotrophic Factor', 'Case-Control Studies', 'Female', 'Humans', 'Male', 'Membrane Glycoproteins', 'Mental Disorders', 'Middle Aged', 'Nerve Tissue Proteins', 'Plasminogen Activator Inhibitor 1', 'Receptor, trkB', 'Receptors, Nerve Growth Factor'] | 28,761,093 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550', 'D12.776.543.550'], ['F03'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The budding yeast polo-like kinase Cdc5 regulates the Ndt80 branch of the meiotic recombination checkpoint pathway. | Defects in chromosome synapsis and/or meiotic recombination activate a surveillance mechanism that blocks meiotic cell cycle progression to prevent anomalous chromosome segregation and formation of aberrant gametes. In the budding yeast zip1 mutant, which lacks a synaptonemal complex component, the meiotic recombinatio... | ['CDC28 Protein Kinase, S cerevisiae', 'Cell Cycle Proteins', 'DNA-Binding Proteins', 'Gene Expression', 'M Phase Cell Cycle Checkpoints', 'Meiosis', 'Nuclear Proteins', 'Protein Kinases', 'Protein-Serine-Threonine Kinases', 'Protein-Tyrosine Kinases', 'Recombination, Genetic', 'Saccharomyces cerevisiae', 'Saccharomyce... | 21,795,394 | [['D08.811.913.696.620.682.700.646.500.500.375', 'D12.644.360.250.067.500', 'D12.776.167.200.067.500', 'D12.776.354.750.124', 'D12.776.476.250.067.500'], ['D12.776.167'], ['D12.776.260'], ['G05.297'], ['G04.144.109.750', 'G04.144.220.220.781.337', 'G05.113.220.781.338'], ['G04.144.220.220.687', 'G05.113.220.687'], ['D1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators. | A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy. | ['Animals', 'Binding, Competitive', 'Crystallography, X-Ray', 'In Vitro Techniques', 'Indicators and Reagents', 'Ligands', 'Male', 'Models, Molecular', 'Muscle, Skeletal', 'Orchiectomy', 'Organ Size', 'Prostate', 'Pyrazoles', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Androgen', 'Structure-Activity Relationship', 'Tes... | 17,079,140 | [['B01.050'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['E05.196.309.742.225'], ['E05.481'], ['D27.720.470.410'], ['D27.720.470.480'], ['E05.599.595'], ['A02.633.567', 'A10.690.552.500'], ['E04.270.282.679', 'E04.950.165.679', 'E04.950.774.860.618'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An Efficient Exact Algorithm for the Motif Stem Search Problem over Large Alphabets. | In recent years, there has been an increasing interest in planted (l, d) motif search (PMS) with applications to discovering significant segments in biological sequences. However, there has been little discussion about PMS over large alphabets. This paper focuses on motif stem search (MSS), which is recently introduced... | ['Algorithms', 'Amino Acid Motifs', 'Computational Biology', 'Computer Simulation', 'Pattern Recognition, Automated', 'Proteins', 'Sequence Analysis, Protein'] | 26,357,225 | [['G17.035', 'L01.224.050'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['H01.158.273.180', 'L01.313.124'], ['L01.224.160'], ['L01.399.750'], ['D12.776'], ['E05.393.760.705']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Evaluation of Behavioral and Susceptibility Patterns in Premenopausal Women with Recurrent Urinary Tract Infections: A Case Control Study. | Recurrent urinary tract infections (UTI) are a major source of morbidity and healthcare costs. Risk factors associated with recurrence rates in premenopausal women can be attributed to patient lifestyle behavior. The aim of this study was to assess hygienic risk factors, determine pathogen distribution, and susceptibil... | ['Adolescent', 'Adult', 'Case-Control Studies', 'Disease Susceptibility', 'Female', 'Health Behavior', 'Humans', 'Hygiene', 'Middle Aged', 'Premenopause', 'Recurrence', 'Risk Factors', 'Urinary Tract Infections', 'Young Adult'] | 29,241,191 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.550.291.687', 'G07.100.250'], ['F01.145.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.547', 'N06.850.670'], ['M01.060.116.630'], ['G08.686.157.500.812', 'G08.686.841.249.500.812'], ['C... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Radiographic evidence of impaired pulmonary function in laterally recumbent anaesthetised horses. | Studies in conscious and anaesthetised ponies demonstrated that starvation, anaesthesia and changes in body position influence the radiographic appearance of the lungs in the lateral and dorsoventral views. Radiographic appearances could not be closely correlated with blood gas values, but they suggested that the volum... | ['Anesthesia', 'Anesthesia, Inhalation', 'Animals', 'Carbon Dioxide', 'Chloral Hydrate', 'Halothane', 'Horses', 'Lung', 'Oxygen', 'Posture', 'Radiography', 'Respiration', 'Starvation'] | 428,360 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
South-South cross-border patient travel to South Africa. | This paper explores intra-regional South-South cross-border patient travel within the context of Southern Africa. South Africa, in particular, has been widely touted as one of the emerging destinations of high-end patients from the Global North alongside other destinations such as Brazil, India, Costa Rica and Thailand... | ['Emigration and Immigration', 'Health Services Accessibility', 'Humans', 'Medical Tourism', 'South Africa'] | 29,235,417 | [['I01.240.600.525.500', 'N01.224.625.525.500', 'N06.850.505.400.700.525.500'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N05.300.515'], ['Z01.058.290.175.735']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Songs as an aid for language acquisition. | In previous research, Saffran and colleagues [Saffran, J. R., Aslin, R. N., & Newport, E. L. (1996). Statistical learning by 8-month-old infants. Science, 274, 1926-1928; Saffran, J. R., Newport, E. L., & Aslin, R. N. (1996). Word segmentation: The role of distributional cues. Journal of Memory and Language, 35, 606-62... | ['Adult', 'Female', 'Humans', 'Language', 'Learning', 'Male', 'Music'] | 17,475,231 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['F02.463.425', 'F02.784.629.529'], ['K01.602']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Effects of the menstrual cycle on sympathetic neural responses to mental stress in humans. | The influence of the menstrual cycle on resting muscle sympathetic nerve activity (MSNA) remains controversial, and the effect of the menstrual cycle on MSNA responses to mental stress is unknown. We examined MSNA, mean arterial pressure (MAP), and heart rate (HR) responses to mental stress (via mental arithmetic) in 1... | ['Adult', 'Blood Pressure', 'Estradiol', 'Female', 'Follicular Phase', 'Heart Rate', 'Humans', 'Luteal Phase', 'Progesterone', 'Stress, Psychological', 'Sympathetic Nervous System'] | 17,932,154 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['G08.686.605.310'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.605.410'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.623', 'D06.472.334... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sarm1/Myd88-5 Regulates Neuronal Intrinsic Immune Response to Traumatic Axonal Injuries. | Traumatic injuries can trigger inflammatory reactions, leading to profound neuropathological consequences. However, the immune capacity of neurons, distinct from that of immune cells or glial cells, in response to traumatic insults remains to be fully characterized. In this study, we demonstrate that neurons can detect... | ['Animals', 'Armadillo Domain Proteins', 'Axons', 'Chemokines', 'Cytokines', 'Cytoskeletal Proteins', 'JNK Mitogen-Activated Protein Kinases', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Myeloid Differentiation Factor 88', 'Neurons', 'RNA Interference', 'RNA, Small Interfering', 'Sciatic Nerve', 'Signal Transducti... | 29,669,278 | [['B01.050'], ['D12.776.091'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['D12.644.276.374.200', 'D12.776.467.374.200', 'D23.125.300', 'D23.469.200', 'D23.529.374.200'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D12.776.220'], ['D08.811.913.696.620.682.700.567.374', 'D12.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Least squares acceleration filtering for the estimation of signal derivatives and sharpness at extrema. | A family of finite impulse-response (FIR) filters is derived which estimate the second derivative or "acceleration" of a digitized signal. The acceleration is obtained from parabolas that are continuously fit to the signal using a least squares optimization criterion. A closed-form solution for the filter coefficients ... | ['Algorithms', 'Artifacts', 'Electrocardiography', 'Electroencephalography', 'Epilepsy', 'Humans', 'Least-Squares Analysis', 'Signal Processing, Computer-Assisted'] | 10,431,462 | [['G17.035', 'L01.224.050'], ['E05.047'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['L01.224.800']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Immunoglobulin heavy-chain enhancer requires one or more tissue-specific factors. | Enhancer sequences are regulatory regions that greatly increase transcription of certain eukaryotic genes. An immunoglobulin heavy-chain variable gene segment is moved from a region lacking enhancer activity to a position adjacent to the known heavy-chain enhancer early in B-cell maturation. In lymphoid cells, the heav... | ['Animals', 'Antibody Formation', 'B-Lymphocytes', 'Base Sequence', 'Cell Line', 'Enhancer Elements, Genetic', 'Fibroblasts', 'Genes, Regulator', 'Humans', 'Immunoglobulin Constant Regions', 'Immunoglobulin Heavy Chains', 'Immunoglobulin Variable Region', 'Mice', 'Transcription, Genetic'] | 3,917,575 | [['B01.050'], ['G12.450.050.370.250'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.360.340.024.340.137.750.249'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Physicochemical characterization and release mechanism of a novel prednisone biodegradable microsphere formulation. | The aim of this work was the characterization of a new formulation of prednisone long-term controlled release biodegradable microspheres. Poly(DL-lactide-co-glycolide) (PLGA) polymers were used for MS preparation. A S/O/W solvent evaporation method was employed for prednisone entrapment. The system was characterized by... | ['Algorithms', 'Anti-Inflammatory Agents', 'Calorimetry, Differential Scanning', 'Chemical Phenomena', 'Chemistry, Pharmaceutical', 'Chemistry, Physical', 'Drug Compounding', 'Excipients', 'Lactic Acid', 'Microscopy, Electron, Scanning', 'Microspheres', 'Models, Chemical', 'Particle Size', 'Polyglycolic Acid', 'Polylac... | 17,721,943 | [['G17.035', 'L01.224.050'], ['D27.505.954.158'], ['E05.196.131.310', 'E05.196.370.310'], ['G02'], ['H01.158.703.007', 'H01.181.466'], ['H01.181.529'], ['E05.916.270'], ['D26.650.700.419', 'D27.720.744.770.419'], ['D02.241.511.459.450'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['E07.565'], ['E05.599.495'], ['G0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Tubularized incised plate hypospadias reoperation. | PURPOSE: We report our updated experience with tubularized incised plate hypospadias reoperations in a series of patients of whom the majority had undergone prior urethral plate incision.MATERIALS AND METHODS: Records of 31 consecutive patients undergoing tubularized incised plate reoperation were reviewed. The decisio... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Humans', 'Hypospadias', 'Infant', 'Male', 'Reoperation', 'Urethra', 'Urologic Surgical Procedures, Male'] | 15,126,861 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.494.400', 'C12.706.516', 'C13.351.875.466', 'C16.131.939.516'], ['M01.060.703'], ['E04.690'], ['A05.360.444.492.726', 'A05.810.876'], ['E04.950.774.860']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of gait after Syme and transtibial amputation in children: factors that may play a role in function. | BACKGROUND: Preservation of maximal limb length during amputation is often recommended to maximize the efficiency and symmetry of gait. The goals of this study were to determine (1) whether there are gait differences between children with a Syme (or Boyd) amputation and those with a transtibial-level amputation, and (2... | ['Adolescent', 'Age Factors', 'Amputation', 'Artificial Limbs', 'Biomechanical Phenomena', 'Child', 'Child, Preschool', 'Female', 'Gait', 'Humans', 'Male', 'Tibia', 'Young Adult'] | 25,274,789 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['E04.555.080'], ['E07.695.050', 'E07.858.082.050', 'E07.858.442.050'], ['G01.154.090', 'G01.374.089'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.043.650.8... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Binding of molecules to DNA and other semiflexible polymers. | A theory is presented for the binding of small molecules such as surfactants to semiflexible polymers. The persistence length is assumed to be large compared to the monomer size but much smaller than the total chain length. Such polymers (e.g., DNA) represent an intermediate case between flexible polymers and stiff, ro... | ['Chemical Phenomena', 'Chemistry, Physical', 'DNA', 'Kinetics', 'Mathematical Computing', 'Models, Chemical', 'Structure-Activity Relationship', 'Surface-Active Agents'] | 11,088,368 | [['G02'], ['H01.181.529'], ['D13.444.308'], ['G01.374.661', 'G02.111.490'], ['L01.224.680'], ['E05.599.495'], ['G02.111.830', 'G07.690.773.997'], ['D27.720.877']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75. | The small GTPase Rac1 has emerged as an important regulator of cell survival and apoptosis, but the mechanisms involved are not completely understood. In this report, constitutively active Rac1 is shown to stimulate the phosphorylation of the Bcl-2 family member Bad, thereby suppressing drug-induced caspase activation ... | ['Animals', 'Apoptosis', 'Carrier Proteins', 'Caspases', 'Cell Line, Tumor', 'Cell Survival', 'Cyclic AMP-Dependent Protein Kinases', 'Drug Resistance, Neoplasm', 'Enzyme Activation', 'Etoposide', 'Humans', 'Lymphoma', 'Mice', 'Nucleic Acid Synthesis Inhibitors', 'Phosphorylation', 'Protein-Serine-Threonine Kinases', '... | 15,226,424 | [['B01.050'], ['G04.146.954.035'], ['D12.776.157'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D08.811.913.696.620.682.700.150.125', 'D12.644.360.200.125', 'D12.776.476.200.125'], ['G07.690.773.984.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization and adsorption capacity of potassium permanganate used to modify activated carbon filter media for indoor formaldehyde removal. | This study examined the effect of potassium permanganate (KMnO4)-modified activated carbon for formaldehyde removal under different face velocities and different initial formaldehyde concentrations in building environment. We chose the coconut shell activated carbon due to their high density and purity. Moreover, they ... | ['Adsorption', 'Air Pollutants', 'Air Pollution, Indoor', 'Charcoal', 'Cocos', 'Diffusion', 'Formaldehyde', 'Kinetics', 'Microscopy, Electron, Scanning', 'Models, Chemical', 'Potassium Permanganate', 'Spectroscopy, Fourier Transform Infrared', 'Surface Properties'] | 30,091,073 | [['G01.030', 'G02.020'], ['D27.888.284.101'], ['N06.850.460.100.080'], ['D01.268.150.150'], ['B01.650.940.800.575.912.250.093.211'], ['G01.202', 'G02.196'], ['D02.047.407'], ['G01.374.661', 'G02.111.490'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['E05.599.495'], ['D01.530.700', 'D01.745.750'], ['E05.196.712.726... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hyperthyroidism and concurrent thyroid malignancies. | In a 17-year period 1848 patients with hyperthyroidism were operated on. Fourteen (0.76%) had a coexisting thyroid malignancy. Preoperative scintiscan and pathologic diagnoses were compared: 10 malignancies were in cold nodules, two were unidentifiable preoperatively due to small size, and two were in hot areas. Five p... | ['Adult', 'Aged', 'Biopsy, Needle', 'Female', 'Goiter, Endemic', 'Graves Disease', 'Humans', 'Hyperthyroidism', 'Male', 'Middle Aged', 'Thyroid Neoplasms'] | 2,740,989 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['C19.874.283.300'], ['C11.675.349.500', 'C19.874.283.605', 'C19.874.397.370', 'C20.111.555'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pigeons learn signal-food intervals independently in a multiple peak procedure. | Previous research has shown rapid learning of multiple temporal relations between signals and food by pigeons when these relations are changed unpredictably each session (Kyonka & Grace, 2007). The goal of the present study was to test whether contextual temporal cues-that is, an alternative signal-food delay that was ... | ['Analysis of Variance', 'Animals', 'Columbidae', 'Conditioning, Operant', 'Cues', 'Feeding Behavior', 'Female', 'Food', 'Male', 'Regression Analysis', 'Reinforcement Schedule'] | 24,364,669 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['B01.050.150.900.248.165.150'], ['F02.463.425.179.509'], ['F02.463.425.234'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['G07.203.300', 'J02.500'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['F02.463.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Focused microbiologic surveillance by specific hospital unit as a sensitive means of defining antimicrobial resistance problems. | An annual summary of susceptibility patterns for the predominant clinical isolates from hospitalized patients can be of considerable assistance in selecting antimicrobial agents for sepsis of unclear etiology, as well as for guiding empiric therapy for other serious infections. Yearly summaries of the susceptibility pa... | ['Adult', 'Aged', 'Anti-Bacterial Agents', 'Bacteria', 'Blood', 'Cross Infection', 'Drug Resistance, Microbial', 'Drug Utilization', 'Female', 'Hospital Units', 'Humans', 'Male', 'Microbial Sensitivity Tests', 'Prevalence', 'Sputum', 'Tennessee', 'Time Factors', 'Urine'] | 1,737,438 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['B03'], ['A12.207.152', 'A15.145'], ['C01.248', 'C23.550.291.875.500'], ['G06.225', 'G07.690.773.984.269'], ['N04.452.706.477'], ['N02.278.388'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats. | PURPOSE: The antineoplastic anthracycline doxorubicin can induce a dose-dependent cardiomyopathy that limits the total cumulative dose prescribed to cancer patients. In both preclinical and clinical studies, pretreatment with dexrazoxane, an intracellular iron chelator, partially protects against anthracycline-induced ... | ['Animals', 'Antibiotics, Antineoplastic', 'Antineoplastic Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Doxorubicin', 'GA-Binding Protein Transcription Factor', 'Gene Expression', 'Gene Expression Profiling', 'Heart Diseases', 'Male', 'Mitochondria, Heart', 'Myocardium', 'Oligonucleotide Array Sequence A... | 19,915,844 | [['B01.050'], ['D27.505.954.248.106'], ['D27.505.954.248'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D12.776.260.615.249', 'D12.776.930.618.249'], ['G05.297'], ['E05.393.332'], ['C14.280'], ['A11.284.430.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of colistin exposure on calcium homeostasis and mitochondria functions in chick cortex neurons. | The study investigated the effect of colistin exposure on calcium homeostasis and mitochondria functions in neurons. We used an in vitro drug model to induce neurotoxicity that closely mimic the in vivo condition by exposing primary cultures of chick cortex neurons to different concentrations of 0, 0.83, 4.15 and 8.3 ì... | ['Animals', 'Anti-Bacterial Agents', 'Calcium', 'Calmodulin', 'Cell Culture Techniques', 'Cell Survival', 'Cerebral Cortex', 'Chick Embryo', 'Colistin', 'Flow Cytometry', 'Homeostasis', 'Membrane Potential, Mitochondrial', 'Microscopy, Electron', 'Mitochondria', 'Neurons', 'Real-Time Polymerase Chain Reaction'] | 23,193,994 | [['B01.050'], ['D27.505.954.122.085'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.346'], ['A08.186.211.200.885.287.500'], ['A13.350.150', 'A16.331.20... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Optogenetic induction of aversive taste memory. | The Drosophila melanogaster gustatory system consists of several neuronal pathways representing diverse taste modalities. The two predominant modalities are a sweet-sensing pathway that mediates attraction, and a bitter-sensing pathway that mediates avoidance. A central question is how flies integrate stimuli from thes... | ['Animals', 'Association Learning', 'Avoidance Learning', 'Behavior, Animal', 'Drosophila', 'Drosophila Proteins', 'Female', 'Infrared Rays', 'Ion Channels', 'Memory', 'Neural Pathways', 'Quinine', 'TRPA1 Cation Channel', 'TRPC Cation Channels', 'Taste'] | 22,820,051 | [['B01.050'], ['F02.463.425.069.296'], ['F02.463.425.097', 'F02.463.785.373.173'], ['F01.145.113'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['G01.358.500.505.650.552', 'G01.590.540.552', 'G01.750.250.650.552', 'G01.750.770.578.552', 'G16.500.275.063.725.525.400', 'G16.500.750.775.525.4... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Platelet-activating factor mediates the ozone-induced increase in airway microvascular leakage in guinea pigs. | In the present study, we asked whether platelet-activating factor (PAF) mediates the ozone-induced increase in airway microvascular leakage. To answer this question, we examined the effect of a PAF receptor antagonist on the ozone-induced increase in airway microvascular leakage quantified by the extravasation of Evans... | ['Animals', 'Azepines', 'Bronchi', 'Capillary Permeability', 'Dose-Response Relationship, Drug', 'Guinea Pigs', 'In Vitro Techniques', 'Inflammation Mediators', 'Male', 'Ozone', 'Platelet Activating Factor', 'Platelet Membrane Glycoproteins', 'Receptors, Cell Surface', 'Receptors, G-Protein-Coupled', 'Respiratory Physi... | 7,796,863 | [['B01.050'], ['D03.383.066'], ['A04.411.125'], ['G03.143.330', 'G09.330.165'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.992.550'], ['E05.481'], ['D23.469'], ['D01.362.670.600'], ['D02.033.100.291.211.500', 'D02.092.063.291.211.500', 'D02.092.877.883.333.710', 'D02.675.276.232.710', 'D10.570.75... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lacrimation induced by thermal stress in patients with a facial nerve lesion. | I measured facial sweating, flushing, and lacrimation during body heating in 10 patients with a facial nerve lesion compromising parasympathetic outflow. During heating, moisture accumulated in the symptomatic eye of patients with facial nerve palsy, particularly in patients with a long-standing lesion. Sweating and fl... | ['Adult', 'Aged', 'Facial Paralysis', 'Female', 'Flushing', 'Hot Temperature', 'Humans', 'Lacrimal Apparatus', 'Male', 'Middle Aged', 'Parasympathetic Nervous System', 'Stress, Physiological', 'Sweating', 'Tears'] | 7,783,873 | [['M01.060.116'], ['M01.060.116.100'], ['C07.465.327', 'C10.597.622.214', 'C23.888.592.636.214'], ['C23.888.885.344'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.371.463',... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
One-stage reconstruction of war wounds with free osteocutaneous flaps. | Thirty-one patients with traumatic osteocutaneous defects of the extremities sustained during the war in Croatia and Bosnia and Herzegovina were treated at the Institute of Plastic-Reconstructive and Breast Surgery in Zagreb. Injuries were categorised using the Mangled Extremity Syndrome Index (MESI). The average lengt... | ['Adult', 'Arm Injuries', 'Blast Injuries', 'Bone Transplantation', 'Bosnia and Herzegovina', 'Croatia', 'Follow-Up Studies', 'Humans', 'Leg Injuries', 'Male', 'Middle Aged', 'Skin Transplantation', 'Surgical Flaps', 'Treatment Outcome', 'Warfare', 'Wounds and Injuries', 'Wounds, Penetrating'] | 9,135,423 | [['M01.060.116'], ['C26.088'], ['C26.120.126'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['Z01.542.248.160'], ['Z01.542.248.295'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.558'], ['M01.060.116.630'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Experimental electron density study of tetrakis-mu-(acetylsalicylate)dicopper(II): a polymeric structure with Cu...Cu short contacts. | The electron density, its topological features, and the electrostatic potential of tetrakis-mu-(acetylsalicylate)dicopper(II), Cu[C(9)H(7)O(4)](2), have been derived from an accurate high-resolution diffraction experiment at 100 K. This complex exhibits a polymeric structure involving one acetyl oxygen atom as a bridge... | ['Aspirin', 'Coordination Complexes', 'Copper', 'Ligands', 'Models, Molecular', 'Polymers', 'Quantum Theory'] | 20,565,050 | [['D02.455.426.559.389.657.410.595.176'], ['D01.234', 'D02.257'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D27.720.470.480'], ['E05.599.595'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['H01.671.579.800']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Macroscopic haemoglobinuria associated with Mycoplasma pneumoniae infection successfully treated by clarithromycin. | A 25-year-old man developed macroscopic haemoglobinuria after a persistent dry cough. Although chest radiograph findings were normal, since the serum antibody for Mycoplasma pneumoniae was significantly elevated, a diagnosis infection with this organism was made. Despite the absence of apparent anaemia, a marked increa... | ['Adult', 'Anti-Bacterial Agents', 'Biomarkers', 'Clarithromycin', 'Cryoglobulins', 'Hemoglobinuria', 'Humans', 'Immunosuppressive Agents', 'Male', 'Mycoplasma Infections', 'Mycoplasma pneumoniae', 'Treatment Outcome'] | 25,819,056 | [['M01.060.116'], ['D27.505.954.122.085'], ['D23.101'], ['D02.540.576.500.992.100'], ['D12.776.124.486.485.900.225', 'D12.776.124.790.651.900.225', 'D12.776.377.715.548.900.225'], ['C12.777.934.734.634', 'C13.351.968.934.734.634', 'C23.888.942.750.634'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.47... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A cohort study of mortality and cancer incidence in ethylene oxide production workers. | Ethylene oxide, important as an intermediate product in the chemical industry and for sterilising hospital equipment, is mutagenic in several organisms; carcinogenicity has been suspected although this had not been supported by clinical data. Ethylene oxide has been produced by a Swedish company since the beginning of ... | ['Chemical Industry', 'Environmental Exposure', 'Ethylene Chlorohydrin', 'Ethylene Dichlorides', 'Ethylene Oxide', 'Humans', 'Leukemia', 'Male', 'Mortality', 'Neoplasms', 'Occupational Diseases', 'Stomach Neoplasms', 'Sweden'] | 508,639 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ontogeny of floral organs in flax (Linum usitatissimum; Linaceae). | PREMISE OF THE STUDY: Flax (Linum usitatissimum) is an important crop worldwide; however, a detailed study on flower development of this species is lacking. Here we describe the pattern of initiation and a program of key developmental events in flax flower ontogeny. This study provides important fundamental information... | ['Flax', 'Flowers', 'Microscopy, Electron, Scanning', 'Organ Specificity'] | 21,730,334 | [['B01.650.940.800.575.912.250.859.797.620.500'], ['A18.024.249.500'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['G07.650']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic â-cells: protection by nifedipine. | Nuclear lamins form the lamina on the interior of the nuclear envelope, and are involved in the regulation of various cellular processes, including DNA replication and chromatin organization. Despite this evidence, little is known about potential alterations in nuclear metabolism, specifically lamin structure and integ... | ['Animals', 'Calcium Channel Blockers', 'Caspase 3', 'Cells, Cultured', 'Cytosol', 'Endoplasmic Reticulum Stress', 'Glucose', 'Humans', 'Insulin-Secreting Cells', 'Lamin Type B', 'Male', 'Nifedipine', 'Phenylbutyrates', 'Rats', 'Rats, Sprague-Dawley', 'Thapsigargin', 'Transcription Factor CHOP'] | 23,994,168 | [['B01.050'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A11.251'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['G04.434... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute kidney injury in older adults. | Aging kidneys undergo structural and functional changes that decrease autoregulatory capacity and increase susceptibility to acute injury. Acute kidney injury associates with duration and location of hospitalization, mortality risk, progression to chronic kidney disease, and functional status in daily living. Definitio... | ['Acute Kidney Injury', 'Aged', 'Aged, 80 and over', 'Aging', 'Biomarkers', 'Creatinine', 'Female', 'Humans', 'Kidney Failure, Chronic', 'Male', 'Risk Factors'] | 21,209,252 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['D23.101'], ['D03.383.129.308.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.7... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Factors influencing smoking behavior in Hong Kong primary schoolchildren: targets for prevention. | The uptake of smoking by children and factors influencing such behavior, although well documented in the West, have not been studied in the Asia-Pacific region. A cross-sectional survey was carried out on 3,521 children, aged 8-11 years living in two districts of Hong Kong. Knowledge, attitude and behavior related to s... | ['Child', 'Cross-Sectional Studies', 'Female', 'Health Knowledge, Attitudes, Practice', 'Hong Kong', 'Humans', 'Male', 'Prevalence', 'Risk Factors', 'Smoking', 'Smoking Prevention', 'Socioeconomic Factors', 'Students', 'Surveys and Questionnaires'] | 9,037,806 | [['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.100.150.500', 'N05.300.150.410'], ['Z01.252.474.164.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.75... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Rheumatic manifestations and dental foci: a review of the cases in 12 years of activity in a pediatrics division]. | By examining 8244 clinical records, in a period of 12 years of paediatric activity, the authors point out the connection between dental caries and rheumatic fever. They suggest fluoride supplementation since the early age, in countries where the fluoride is lack in drink able-water. | ['Adolescent', 'Child', 'Child, Preschool', 'Dental Caries', 'Fluoridation', 'Hospital Departments', 'Humans', 'Incidence', 'Italy', 'Pediatrics', 'Rheumatic Fever'] | 8,415,180 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C07.793.720.210'], ['E06.761.382', 'N06.890.235'], ['N02.278.216.500.968', 'N04.452.442.452.422'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Locating a site on the maize B chromosome that controls preferential fertilization. | In maize, the B chromosome can undergo nondisjunction at the second pollen mitosis, producing sperm with two B chromosomes and sperm with zero B chromosomes. Preferential fertilization is the ability of the sperm carrying two B chromosomes to transmit more frequently to the embryo of a kernel than the sperm lacking the... | ['Chromosomal Instability', 'Chromosome Mapping', 'Chromosomes, Plant', 'Fertilization', 'Genes, Recessive', 'Zea mays'] | 17,632,579 | [['C23.550.210.110', 'C23.550.362.180', 'G05.365.590.175.165', 'G05.370.180'], ['E05.393.183'], ['A11.284.187.560', 'A18.005', 'G05.360.162.560'], ['G08.686.784.277'], ['G05.360.340.024.340.415', 'G05.420.325'], ['B01.650.940.800.575.912.250.822.966']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The clinical pharmacokinetics of buflomedil in normal subjects after intravenous and oral administration. | A dose-ranging pharmacokinetic study of buflomedil was carried out in eight subjects to determine the pharmacokinetic parameters of the drug after oral and intravenous administration. Based on AUC infinity analyses, the pharmacokinetics of buflomedil were found to be linear within the dose ranges studied (50 to 200 mg ... | ['Administration, Oral', 'Adult', 'Butyrophenones', 'Humans', 'Injections, Intravenous', 'Kinetics', 'Male', 'Pyrrolidines', 'Vasodilator Agents'] | 7,286,057 | [['E02.319.267.100'], ['M01.060.116'], ['D02.522.352'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['G01.374.661', 'G02.111.490'], ['D03.383.773'], ['D27.505.954.411.918']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Time trends in type 2 diabetes patients' disease management and outcomes: evidence from two KORA surveys in Germany. | To explore time trends in diabetes management and intermediate health outcomes of people with type 2 diabetes, data from two population-based survey studies were compared. The surveys were conducted in the Augsburg region of Southern Germany in 1997/98 and in 2004/05, and included physical examinations, interviews, sel... | ['Adult', 'Aged', 'Aged, 80 and over', 'Diabetes Mellitus, Type 2', 'Female', 'Germany', 'Health Surveys', 'Humans', 'Male', 'Middle Aged', 'Time Factors', 'Treatment Outcome'] | 18,726,868 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C18.452.394.750.149', 'C19.246.300'], ['Z01.542.315'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G01.910.857'], ['E01.789.800', 'N04.761.559.590.... | ['Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Establishment of a highly differentiated immortalized human cholangiocyte cell line with SV40T and hTERT. | BACKGROUND: Cholangiocytes perform an essential role in important pathophysiologic functions in the liver. Establishment of a human cholangiocyte line facilitates advances in cholangiocyte research and clinical applications for cell therapies. Here, we describe the immortalization of human cholangiocytes using serial t... | ['Animals', 'Antigens, Polyomavirus Transforming', 'Biocompatible Materials', 'Biomarkers', 'Cell Differentiation', 'Cell Line, Transformed', 'Cell Transplantation', 'Collagen', 'DNA-Binding Proteins', 'Drug Combinations', 'Humans', 'Interleukin-6', 'Laminin', 'Lipopolysaccharides', 'Liver', 'Mice', 'Mice, SCID', 'Micr... | 14,966,424 | [['B01.050'], ['D12.776.624.664.520.090', 'D12.776.964.700.090', 'D23.050.285.062.090', 'D23.050.327.062.090'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D23.101'], ['G04.152'], ['A11.251.210.172'], ['E02.095.147.500', 'E04.936.225'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D12.776.260'], ['D26.310'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Large Salt Dust Storms Follow a 30-Year Rainfall Cycle in the Mar Chiquita Lake (C?rdoba, Argentina). | Starting in 2006, a new source of intense salt dust storms developed in Mar Chiquita (C?rdoba, Argentina), the largest saline lake in South America. Storms originate from vast mudflats left by a 30-year expansion-retreat cycle of the lake due to changes in the regional rainfall regime. The annual frequency of salt dust... | ['Argentina', 'Computer Simulation', 'Dust', 'Environmental Monitoring', 'Lakes', 'Rain', 'Seasons', 'Sodium Chloride', 'Temperature'] | 27,258,088 | [['Z01.107.757.077'], ['L01.224.160'], ['D20.633.222'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G01.311.580', 'G16.500.275.280.500', 'N06.230.232.500'], ['G16.500.175.859', 'G16.500.275.063.725.395', 'G16.500.750.775.450', 'N06.230.300.100.725.450', 'N06.230.520'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.... | ['Geographicals [Z]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
[Investigation of short-term therapy results for radiofrequency ablation by positron emission tomography]. | OBJECTIVE: To explore the possibility of evaluating the short-term therapeulic effect of radiofrequency ablation (RFA) in cancer treatment by positron emission tomography.METHODS: The radioactivity intensity of the tumor was detected by PET before and after RFA.RESULTS: Radioactivity blank was observed in all 33 cases ... | ['Adult', 'Aged', 'Catheter Ablation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Tomography, Emission-Computed', 'Treatment Outcome'] | 12,390,754 | [['M01.060.116'], ['M01.060.116.100'], ['E02.808.750.500', 'E04.014.760.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04'], ['E01.370.350.350.800', 'E01.370.350.600.350.800', 'E01.370.350.710.800', 'E01.370.350.825.800', 'E01.370.384.730.800'], ['E01.789.800', 'N04.761.559.590.800', 'N... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Specificity studies of the GDP-[L]-fucose: 2-acetamido-2-deoxy-beta-[D]-glucoside (Fuc-->Asn-linked GlcNAc) 6-alpha-[L]-fucosyltransferase from rat-liver Golgi membranes. | The specificity of Golgi-membrane glycoprotein 6-alpha-[L]-fucosyltransferase [GDP-[L]-fucose: 2-acetamido-2-deoxy- beta-[D]-glucoside (Fuc-->Asn-linked GlcNAc) 6-alpha-[L]-fucosyltransferase; EC 2.4.1.68] has been assessed with regard to substrate covalent structures and the effect of a protein matrix on the conformat... | ['Animals', 'Asparagine', 'Bacterial Proteins', 'Biotin', 'Carbohydrate Sequence', 'Fucosyltransferases', 'Golgi Apparatus', 'Liver', 'Mannose', 'Models, Molecular', 'Molecular Sequence Data', 'Oligosaccharides', 'Protein Binding', 'Rats', 'Spectrometry, Mass, Fast Atom Bombardment', 'Streptavidin', 'Substrate Specific... | 8,149,370 | [['B01.050'], ['D12.125.068.060', 'D12.125.095.165', 'D12.125.154.049'], ['D12.776.097'], ['D03.383.129.308.080', 'D08.211.096'], ['G02.111.570.160', 'L01.453.245.667.160'], ['D08.811.913.400.450.300'], ['A11.284.430.214.190.875.336'], ['A03.620'], ['D09.947.875.359.588'], ['E05.599.595'], ['L01.453.245.667'], ['D09.69... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Identification of novel substrates and structure-activity relationship of cellular uptake mediated by human organic cation transporters 1 and 2. | Recently the clinical importance of human organic cation transporters 1 (hOCT1/SLC22A1) and 2 (hOCT2/SLC22A2) in drug disposition, for example, clearance, toxicity, and drug-drug interactions, have been highlighted [Annu. Rev. Pharmacol. Toxicol. 2012, 52, 249-273; Nat. Rev. Drug Discovery 2010, 9 (3), 215-236]. Conseq... | ['Biological Transport', 'Chemical Phenomena', 'Drug Evaluation, Preclinical', 'HEK293 Cells', 'Humans', 'Organic Cation Transport Proteins', 'Organic Cation Transporter 1', 'Organic Cation Transporter 2', 'Pharmaceutical Preparations', 'Reproducibility of Results', 'Structure-Activity Relationship', 'Substrate Specifi... | 23,984,907 | [['G03.143'], ['G02'], ['E05.290.750', 'E05.337.550'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.450.250.812', 'D12.776.157.530.937.612', 'D12.776.543.585.450.250.812', 'D12.776.543.585.937.701'], ['D12.776.157.530.450.250.812.500', 'D12.776.157.530.937.6... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
HCOP: a searchable database of human orthology predictions. | The HUGO Gene Nomenclature Committee (HGNC) Comparison of Orthology Predictions (HCOP) search tool combines the human, mouse, rat and chicken orthology assertions made by PhIGs, HomoloGene, Ensembl, Inparanoid, Mouse Genome Informatics (MGI) and HGNC, enabling users to identify predicted ortholog pairs for a specified ... | ['Databases, Genetic', 'Evolution, Molecular', 'Genes', 'Genomics', 'Humans', 'Sequence Homology, Nucleic Acid', 'Terminology as Topic'] | 16,951,416 | [['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.024.340'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.810.550', 'G05.810.550'], ['L01.559.598.400']] | ['Information Science [L]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Vitamin D-dependent rickets: a resurgence of the rachitic lung in the 21st century. | Respiratory complications of rickets may be life-threatening particularly in developing countries. A 7-month-old boy presented with recurrent infections, seizures, failure to thrive, wheezing and respiratory distress progressing to global respiratory failure. Several antimicrobial regimens, bronchodilators and corticos... | ['Calcifediol', 'Calcitriol', 'Calcium', 'Delayed Diagnosis', 'Familial Hypophosphatemic Rickets', 'Humans', 'Infant', 'Male', 'Portugal', 'Radiography, Thoracic', 'Tomography, X-Ray Computed', 'Vitamin D Deficiency'] | 26,483,391 | [['D04.210.500.247.222.159.478.250', 'D04.210.500.247.808.146.478.250', 'D04.210.500.812.768.196.478.250', 'D10.570.938.146.478.250'], ['D04.210.500.247.222.159.478.387.300', 'D04.210.500.247.808.146.478.387.300', 'D04.210.500.812.768.196.478.387.300', 'D10.570.938.146.478.387.300'], ['D01.268.552.100', 'D01.552.539.28... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Psychosis following acute alteration of thyroid status. | OBJECTIVE: Mania with psychotic features presenting following abrupt normalisation of thyroid function from severe Graves's disease is reported.CLINICAL PICTURE: A 33-year-old man with severe, untreated Graves's disease was treated aggressively, with rapid restoration of normal serum thyroid hormone levels. Symptoms of... | ['Adult', 'Antithyroid Agents', 'Bipolar Disorder', 'Combined Modality Therapy', 'Diagnosis, Differential', 'Graves Disease', 'Haloperidol', 'Humans', 'Male', 'Neurocognitive Disorders', 'Thyroid Function Tests'] | 9,400,884 | [['M01.060.116'], ['D06.347.100', 'D27.505.696.399.450.100'], ['F03.084.500'], ['E02.186'], ['E01.171'], ['C11.675.349.500', 'C19.874.283.605', 'C19.874.397.370', 'C20.111.555'], ['D02.522.352.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.615'], ['E01.370.374.750']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Fiber type changes in denervated soleus muscles of the hyperthyroid rat. | The thyroid status of rats is known to influence the histochemical and biochemical myosin adenosine triphosphatase (M-ATPase) activity of the soleus muscle. In the hypothyroid state, denervated soleus muscles are not subject to that influence. Our experiments indicated that in the hyperthyroid state fibers of the dener... | ['Adenosine Triphosphatases', 'Animals', 'Female', 'Hyperthyroidism', 'Muscle Contraction', 'Muscle Denervation', 'Muscles', 'Rats', 'Rats, Inbred Strains', 'Triiodothyronine'] | 6,219,891 | [['D08.811.277.040.025'], ['B01.050'], ['C19.874.397'], ['G11.427.494'], ['E04.525.210.500', 'E04.525.210.560.500'], ['A02.633', 'A10.690'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D06.472.931.740.385', 'D12.125.072.050.767.741.894']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A). | A 7 alpha-hydroxylation is necessary for conversion of both cholesterol and 27-hydroxycholesterol into bile acids. According to current theories, cholesterol 7 alpha-hydroxylase (CYP7A) is responsible for the former and oxysterol 7 alpha-hydroxylase (CYP7B) for the latter reaction. CYP7A is believed to have a very high... | ['Animals', 'COS Cells', 'Catalysis', 'Cholesterol 7-alpha-Hydroxylase', 'Cytochrome P-450 Enzyme System', 'Cytochrome P450 Family 7', 'Humans', 'Kidney', 'Liver', 'Male', 'Rats', 'Recombinant Proteins', 'Steroid Hydroxylases', 'Sterols', 'Swine'] | 10,882,719 | [['B01.050'], ['A11.251.210.172.500', 'A11.329.228.220'], ['G02.130'], ['D08.244.453.890.500', 'D08.244.453.915.200', 'D08.811.682.690.708.170.890.500', 'D08.811.682.690.708.170.915.200', 'D12.776.422.220.453.890.500', 'D12.776.422.220.453.915.200'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Progestin represses human connexin43 gene expression similarly in primary cultures of myometrial and uterine leiomyoma cells. | The mechanism by which progestin represses the expression of the human connexin43 (cx43) gene was analyzed in primary cultures of human myometrial cells, and for comparison, in primary cultures of uterine leiomyoma cells. Within 24 h, the levels of connexin43 (Cx43) protein in primary cells treated with progestin were ... | ['Cells, Cultured', 'Connexin 43', 'Female', 'Gene Expression', 'Humans', 'Leiomyoma', 'Muscle, Smooth', 'Myometrium', 'Progestins', 'RNA, Messenger', 'Receptors, Progesterone', 'Transcription, Genetic', 'Uterine Neoplasms'] | 8,835,382 | [['A11.251'], ['D12.776.543.585.250.200'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.590.450'], ['A02.633.570', 'A10.690.467'], ['A02.633.570.500', 'A05.360.319.679.690', 'A10.690.467.500'], ['D27.505.696.399.472.858'], ['D13.444.735.544'], ['D12.776.826.750.765'], ['G02.111.873', 'G05... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantitative proteomics reveals myosin and actin as promising saliva biomarkers for distinguishing pre-malignant and malignant oral lesions. | BACKGROUND: Oral cancer survival rates increase significantly when it is detected and treated early. Unfortunately, clinicians now lack tests which easily and reliably distinguish pre-malignant oral lesions from those already transitioned to malignancy. A test for proteins, ones found in non-invasively-collected whole ... | ['Actins', 'Biomarkers', 'Chromatography, High Pressure Liquid', 'Humans', 'Mouth Neoplasms', 'Myosins', 'Precancerous Conditions', 'Proteomics', 'Sensitivity and Specificity', 'Tandem Mass Spectrometry'] | 20,567,502 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['D23.101'], ['E05.196.181.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.591', 'C07.465.530'], ['D05.750.078.730.475', 'D08.811.277.040.025.193.750', 'D12.776.210.500.600', 'D12.776.220.525.475'], ['C04.834'], ['H01.158.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Detection of herpesvirus infection of the CNS: the experience of hospital Geral de Santo Ant?nio. | BACKGROUND: PCR detection of CSF Herpes virus DNA is an important tool in the diagnosis of CNS infections. Use of this test has been shown to have an impact on patient management as measured by shortened patient stays, specific therapeutic intervention, reduction of empirical expensive therapy administration, all of wh... | ['Central Nervous System Viral Diseases', 'DNA, Viral', 'Herpesviridae', 'Herpesviridae Infections', 'Hospitals', 'Humans', 'Polymerase Chain Reaction', 'Portugal', 'Sensitivity and Specificity'] | 12,091,082 | [['C01.207.245', 'C01.925.182', 'C10.228.228.245'], ['D13.444.308.568'], ['B04.280.382'], ['C01.925.256.466'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.620.500'], ['Z01.542.727'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The AT-rich tract of the SV40 ori core: negative synergism and specific recognition by single stranded and duplex DNA binding proteins. | The SV40 origin of replication comprises a run of thymine and adenine residues. Integrity of this AT-rich sequence is known to be essential for replication. We set out to study whether or not these elements can work synergistically to sustain replication. Quite surprisingly, additional copies of the AT stretch linked t... | ['Base Sequence', 'Binding Sites', 'DNA Replication', 'DNA, Single-Stranded', 'DNA, Viral', 'DNA-Binding Proteins', 'Molecular Sequence Data', 'Oligodeoxyribonucleotides', 'Plasmids', 'Simian virus 40', 'Viral Proteins'] | 1,321,411 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['G02.111.225', 'G05.226'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['D13.444.308.568'], ['D12.776.260'], ['L01.453.245.667'], ['D13.695.578.424.450'], ['G05.360.600'], ['B04.280.210.700.615.700', 'B04.613.204.67... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Role of caveolin-1 in atrial fibrillation as an anti-fibrotic signaling molecule in human atrial fibroblasts. | Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the general population; yet, the precise mechanisms resulting in AF are not fully understood. Caveolin-1 (Cav-1), the principal structural component of caveolae organelles in cardiac fibroblasts, is involved in several cardiovascular conditions... | ['Adult', 'Aged', 'Atrial Fibrillation', 'Atrial Remodeling', 'Caveolin 1', 'Collagen', 'Down-Regulation', 'Female', 'Fibroblasts', 'Gene Knockdown Techniques', 'Heart Atria', 'Humans', 'Male', 'Middle Aged', 'Peptide Fragments', 'Protein Structure, Tertiary', 'RNA, Small Interfering', 'Signal Transduction', 'Smad Prot... | 24,454,806 | [['M01.060.116'], ['M01.060.116.100'], ['C14.280.067.198', 'C23.550.073.198'], ['C23.300.052', 'C23.550.113', 'G09.330.040.800'], ['D12.644.360.024.264', 'D12.776.157.057.010', 'D12.776.476.024.280', 'D12.776.543.990.100.500', 'D12.776.744.287'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G02.111.240', 'G05.308.200'... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. | The molecular mechanisms underlying the formation of carriers trafficking from the Golgi complex to the cell surface are still ill-defined; nevertheless, the involvement of a lipid-based machinery is well established. This includes phosphatidylinositol 4-phosphate (PtdIns(4)P), the precursor for phosphatidylinositol 4,... | ['ADP-Ribosylation Factors', 'Adaptor Proteins, Signal Transducing', 'Animals', 'Biological Transport', 'COS Cells', 'Carrier Proteins', 'Cell Membrane', 'Fungal Proteins', 'Golgi Apparatus', 'Humans', 'Molecular Sequence Data', 'Phosphatidylinositol Phosphates', 'Protein Structure, Tertiary', 'RNA, Small Interfering',... | 15,107,860 | [['D08.811.277.040.330.300.400.100', 'D12.644.360.525.100', 'D12.776.157.325.515.100', 'D12.776.476.525.100'], ['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['G03.143'], ['A11.251.210.172.500', 'A11.329.228.220'], ['D12.776.157'], ['A11.284.149'], ['D12.776.354'], ['A11.284.430.214.190.875.336... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[X-linked mental retardation: variations in the fragile X mutations and genetic counseling]. | The fragile X syndrome is one of the most common forms of genetic mental retardation and is caused by elongation of a small target DNA fragment containing a repeat of the trinucleotide CGG located in a 5' exon of the FMR-1 gene on the X chromosome. The genetic mutations were classified as two main types, premutation an... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Chromosome Aberrations', 'Chromosome Disorders', 'Female', 'Fragile X Syndrome', 'Genetic Counseling', 'Humans', 'Intellectual Disability', 'Male', 'Middle Aged'] | 8,219,287 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.210', 'G05.365.590.175'], ['C16.131.260', 'C16.320.180'], ['C10.597.606.360.455.500', 'C16.131.260.830.300', 'C16.320.180.830.300', 'C16.320.322.500.500', 'C16.320.400.525.500'], ['H01.158.273.343.385.500.384', 'N02.421.308.400'], ['B01.... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Mortality In Patients With Respiratory And Nonrespiratory Carbapenem Resistant-Multidrug Resistant Acinetobacter Infections. | BACKGROUND: Mortality from carbapenem-multi-drug resistant Acinetobacter infections may vary according to site of infection. The objective of this study was to compare mortality in respiratory vs. non-respiratory infection with Carbapenem-Multi-drug Resistant Acinetobacter (C-MRAB).METHODS: We conducted a prospective c... | ['Acinetobacter Infections', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Carbapenems', 'Cohort Studies', 'Drug Resistance, Multiple, Bacterial', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pakistan', 'Respiratory Tract Infections', 'Young Adult'] | 29,076,697 | [['C01.150.252.400.560.022'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['D02.065.589.099.124', 'D03.633.100.300.124'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.26... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Association of donor-specific blood transfusion enhancement of rat renal allografts with accelerated development of antiidiotypic antibodies and reduced alloantibody responses. | Pretransplant donor-specific blood transfusion (DSBT) has been shown to enhance renal allograft survival in man and indefinitely prolong renal transplants among various MHC-disparate rat strains. Using PVG (RT1c) recipients and ACI (RT1a) donor-strain rats, DSBT alone was found to elicit complement-dependent cytotoxic ... | ['Animals', 'Antibodies, Anti-Idiotypic', 'Antibody Specificity', 'Blood Transfusion', 'Immunoglobulin M', 'Isoantibodies', 'Kidney Transplantation', 'Male', 'Rats', 'Rats, Inbred Strains', 'Transplantation, Homologous'] | 2,301,006 | [['B01.050'], ['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['G12.100'], ['E02.095.135'], ['D12.776.124.486.485.114.619.574', 'D12.776.124.790.651.114.619.574', 'D12.776.377.715.548.114.619.574'], ['D12.776.124.486.485.114.664', 'D12.776.124.790.651.114.664', 'D12.776.37... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Programmed environment management of confined microsocieties. | A programmed environment is described that assists the implementation and management of schedules governing access to all resources and information potentially available to members of a confined microsociety. Living and work schedules are presented that were designed to build individual and group performance repertoire... | ['Behavior', 'Ecological Systems, Closed', 'Humans', 'Social Environment', 'Space Flight', 'Task Performance and Analysis'] | 2,903,733 | [['F01.145'], ['G16.500.275.157.240', 'N06.230.124.240', 'N06.230.150.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.853.500'], ['J01.937.285.850'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
High frequency oscillations and high frequency functional network characteristics in the intraoperative electrocorticogram in epilepsy. | OBJECTIVE: High frequency oscillations (HFOs; > 80 Hz), especially fast ripples (FRs, 250-500 Hz), are novel biomarkers for epileptogenic tissue. The pathophysiology suggests enhanced functional connectivity within FR generating tissue. Our aim was to determine the relation between brain areas showing FRs and 'baseline... | ['Adolescent', 'Adult', 'Brain Waves', 'Child', 'Child, Preschool', 'Electrocorticography', 'Epilepsy', 'Female', 'Gamma Rhythm', 'Humans', 'Male', 'Middle Aged', 'Nerve Net', 'Young Adult'] | 27,882,298 | [['M01.060.057'], ['M01.060.116'], ['E01.370.376.300.150', 'E01.370.405.245.287', 'G07.265.087', 'G11.561.127'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.376.300.294', 'E01.370.405.245.431'], ['C10.228.140.490'], ['E01.370.376.300.150.906', 'E01.370.405.245.287.906', 'G07.265.087.906', 'G11.561.127.906'], ['B01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Vertical eye movement-related type II neurons with downward on-directions in the vestibular nucleus in alert cats. | The vestibular nuclei and the interstitial nucleus of Cajal (INC) have been regarded as key elements of the velocity-to-position integrator for vertical eye movements. This paper reports a class of type II vestibular neurons that receives input from the INC and carries vertical eye movement signals that appear to repre... | ['Action Potentials', 'Afferent Pathways', 'Animals', 'Cats', 'Eye Movements', 'Mesencephalon', 'Neurons', 'Reaction Time', 'Reflex, Vestibulo-Ocular', 'Saccades', 'Semicircular Canals', 'Vestibular Nuclei', 'Wakefulness'] | 14,722,700 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['A08.612.220'], ['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['G11.427.410.140', 'G14.350'], ['A08.186.211.132.659'], ['A08.675', 'A11.671'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['G07.888.937', 'G11.561.731.795'], ['G14.... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel linear epitope crossing Group 1 and Group 2 influenza A viruses located in the helix A of HA2 derived from H7N9. | In this research, four monoclonal antibodies (mAbs) were first generated as an immunogen by using the GST fusion protein that carries the fusion peptide and helix A derived from H7N9 influenza A virus (IAV). These mAbs could react with HA of H7N9, H3N2, and H9N2 with neutralizing activity. A novel linear epitope recogn... | ['Animals', 'Antibodies, Monoclonal', 'Antibodies, Viral', 'Cross Reactions', 'Enzyme-Linked Immunosorbent Assay', 'Epitope Mapping', 'Epitopes, B-Lymphocyte', 'Hemagglutinins, Viral', 'Humans', 'Influenza A Virus, H3N2 Subtype', 'Influenza A Virus, H7N9 Subtype', 'Influenza A Virus, H9N2 Subtype', 'Influenza, Human', ... | 30,593,378 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['G12.122.281'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
X-ray analyses of hybrid duplexes between antisense oligonucleotides containing 5-(N-aminohexyl)carbamoyl-2'-O-methyluridine and their target RNAs. | Incorporation of 5-(N-aminohexyl)carbamoyl-2'-O-methyluridine ((N)Um) into oligonucleotides increases antisense properties such as RNA binding affinity, nuclease resistance and RNase H activity. The present X-ray studies on hybrid duplexes formed between antisense oligonucleotides containing (N)Um and their target RNAs... | ['Crystallography, X-Ray', 'Models, Molecular', 'Nucleic Acid Conformation', 'Oligodeoxyribonucleotides, Antisense', 'RNA', 'Uridine'] | 17,150,635 | [['E05.196.309.742.225'], ['E05.599.595'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.150.200.640', 'D13.150.480.640', 'D13.444.308.150.640', 'D13.444.600.150.200.640', 'D13.444.600.150.640.640', 'D13.695.578.424.480.640', 'D27.720.470.530.600.150.200.640', 'D27.720.470.530.600.150.640.640'], ['D13.444.735'], ['D03.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tissue culture study on neuronal migration in the rat cerebral cortex: effects of low dose radiation. | In order to elucidate the molecular mechanisms underlying neuronal migration in the developing rat cerebral cortex, a novel primary tissue culture system in which neuronal migration can be evaluated was developed. Using this culture system, through autoradiographic studies we demonstrated the migration of [3H]thymidine... | ['Animals', 'Autoradiography', 'Cell Adhesion Molecules', 'Cell Movement', 'Cerebral Cortex', 'Culture Techniques', 'Cytoskeleton', 'Immunohistochemistry', 'Neurons', 'Rats', 'Rats, Wistar', 'Thymidine'] | 9,408,590 | [['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['G04.198', 'G07.568.500.180'], ['A08.186.211.200.885.287.500'], ['E05.481.500'], ['A11.284.430.214.190.750'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Total nitrogen vs. amino-acid profile as indicator of protein content of beef. | In most cited food composition studies and tables, the proximate system measures protein as total nitrogen (N) (determined by Kjeldahl or Dumas method) multiplied by a specific factor. A factor of 6.25 is used for determining total protein from total N (Jones, Munsey, & Walker, 1942). Although more expensive, it is con... | ['Amino Acids', 'Animals', 'Cattle', 'Fatty Acids', 'Meat', 'Muscle, Skeletal', 'Nitrogen', 'Nutritive Value'] | 23,601,414 | [['D12.125'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D10.251'], ['G07.203.300.600', 'J02.500.600'], ['A02.633.567', 'A10.690.552.500'], ['D01.268.604', 'D01.362.625'], ['G07.203.650.660', 'J01.576.423.850.730.750', 'N06.850.601.750']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Reaction of oxygen with the respiratory chain in cells and tissues. | This paper considers the way in which the oxygen reaction described by Dr. Nicholls and the ADP control reactions described by Dr. Racker could cooperate to establish a purposeful metabolic control phenomenon in vivo. This has required an examination of the kinetic properties of the respiratory chain with particular re... | ['Adenine Nucleotides', 'Animals', 'Cytochromes', 'Electron Transport Complex IV', 'Fluorometry', 'In Vitro Techniques', 'Kinetics', 'Mitochondria', 'Oxidoreductases', 'Oxygen', 'Polarography', 'Rats', 'Succinate Dehydrogenase'] | 4,285,727 | [['D03.633.100.759.646.138', 'D13.695.667.138', 'D13.695.827.068'], ['B01.050'], ['D08.244', 'D12.776.422.220'], ['D05.500.562.374', 'D08.811.600.250.687', 'D08.811.682.285', 'D12.776.157.530.450.250.875.304', 'D12.776.543.277.687', 'D12.776.543.585.450.250.875.484'], ['E05.196.712.516.600'], ['E05.481'], ['G01.374.661... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prothrombin deficiency results in embryonic and neonatal lethality in mice. | The conversion of prothrombin (FII) to the serine protease, thrombin (FIIa), is a key step in the coagulation cascade because FIIa triggers platelet activation, converts fibrinogen to fibrin, and activates regulatory pathways that both promote and ultimately suppress coagulation. However, several observations suggest t... | ['Alleles', 'Animals', 'Fetal Death', 'Gene Targeting', 'Hemorrhage', 'Hypoprothrombinemias', 'Mice', 'Mice, Knockout', 'Prothrombin', 'Prothrombin Time'] | 9,636,195 | [['G05.360.340.024.340.030'], ['B01.050'], ['C13.703.223', 'C23.550.260.585'], ['E05.393.335'], ['C23.550.414'], ['C15.378.100.100.550', 'C15.378.100.141.550', 'C15.378.463.550', 'C16.320.099.550'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.550.455... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The financial performance of rural hospitals and implications for elimination of the Critical Access Hospital program. | PURPOSE: To compare the financial performance of rural hospitals with Medicare payment provisions to those paid under prospective payment and to estimate the financial consequences of elimination of the Critical Access Hospital (CAH) program.METHODS: Financial data for 2004-2010 were collected from the Healthcare Cost ... | ['Computer Simulation', 'Financial Management, Hospital', 'Health Services Accessibility', 'Hospitals, Rural', 'Humans', 'Medicare', 'Models, Economic', 'Prospective Payment System', 'Time Factors', 'United States'] | 23,551,644 | [['L01.224.160'], ['N02.278.216.500.875', 'N03.219.463.280', 'N04.452.442.452.180'], ['N04.590.374.350', 'N05.300.430'], ['N02.278.421.518'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.346.506.564.663', 'N03.219.521.576.343.840', 'N03.706.615.696'], ['E05.318.740.500.600', 'E05.599.835.890', 'N05.71... | ['Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Preparing Educators to Implement Flipped Classrooms as a Teaching Strategy. | Educators are not able to change teaching strategies unless they have experience with a new strategy. A 4-hour course was developed to support educators to teach differently. | ['Curriculum', 'Education, Nursing, Continuing', 'Faculty, Nursing', 'Humans', 'Learning', 'Teaching'] | 26,247,655 | [['I02.158'], ['I02.358.212.450', 'I02.358.462.399'], ['M01.526.485.390', 'M01.526.702.250.473', 'N02.360.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['I02.903']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Third order nonlinear optical property of Bi₂Se₃. | The third order nonlinear optical property of Bi₂Se₃, a kind of topological insulator (TI), has been investigated under femto-second laser excitation. The open and closed aperture Z-scan measurements were used to unambiguously distinguish the real and imaginary part of the third order optical nonlinearity of the TI. Wh... | ['Bismuth', 'Lasers', 'Materials Testing', 'Nonlinear Dynamics', 'Scattering, Radiation', 'Selenium'] | 23,389,188 | [['D01.268.271.245', 'D01.268.556.100', 'D01.496.749.305.245', 'D01.552.544.100'], ['E07.632.490', 'E07.710.520'], ['E05.570'], ['E05.599.850', 'H01.548.675'], ['E05.196.822', 'G01.867'], ['D01.268.185.850', 'D01.578.700']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Mathematical foundations of the dendritic growth models. | At present two growth models describe successfully the distribution of size and topological complexity in populations of dendritic trees with considerable accuracy and simplicity, the BE model (Van Pelt et al. in J. Comp. Neurol. 387:325-340, 1997) and the S model (Van Pelt and Verwer in Bull. Math. Biol. 48:197-211, 1... | ['Algorithms', 'Animals', 'Dendrites', 'Humans', 'Likelihood Functions', 'Mathematics', 'Models, Neurological', 'Models, Statistical', 'Neurons', 'Stochastic Processes'] | 17,646,989 | [['G17.035', 'L01.224.050'], ['B01.050'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.520.830.600.400'], ['H... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver. | We have identified in rabbits two hepatic forms of T669 peptide kinases that are very strongly activated after systemic injection with the inflammatory cytokine interleukin 1 (IL-1). The T669 peptide contains a major phosphorylation site of the epidermal growth factor receptor, threonine 699 and is a substrate for mito... | ['Amino Acid Sequence', 'Animals', 'Calcium-Calmodulin-Dependent Protein Kinases', 'Chromatography, Affinity', 'Chromatography, Gel', 'Chromatography, Ion Exchange', 'Electrophoresis, Polyacrylamide Gel', 'Enzyme Activation', 'ErbB Receptors', 'Humans', 'Interleukin-1', 'Isoenzymes', 'Kinetics', 'Liver', 'Molecular Seq... | 7,964,479 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D08.811.913.696.620.682.700.125', 'D12.644.360.100', 'D12.776.476.100'], ['E05.196.181.400.170'], ['E05.196.181.400.250'], ['E05.196.181.400.383'], ['E05.196.401.402', 'E05.301.300.319'], ['G02.111.263', 'G03.328'], ['D08.811.913.696.620.682.725.400.009', 'D12... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Correlation of diameters of secretory granules in clinically non-functioning chromophobe adenomas of the pituitary with those of normal thyrotrophs. | Diameters of secretory granules in thyrotrophs in gonadotrophs were measured in electron micrographs of operation specimens of 4 pituitary glands and of the secretory granules in operation specimens of 10 clinically non-functioning chromophobe adenomas. The mean diameter of the thyrotroph granules was 137 plus or minus... | ['Adenoma, Chromophobe', 'Cytoplasmic Granules', 'Humans', 'Pituitary Neoplasms', 'Thyrotropin'] | 1,173,499 | [['C04.557.465.625.650.095', 'C04.557.470.035.095', 'C04.557.580.625.650.095'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.322.609', 'C04.588.614.250.195.885.500.600', 'C10.228.140.211.885.500.600', 'C10.228.140.617.477.600', 'C10.228.140.6... | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The Leksell gamma knife--a radiosurgery instrument]. | Radiosurgery means delivery of a single dose of precisely directed ionizing radiation to a small volume of intracranial tissue without opening of the skull after the stereotactic localisation of the preselected target. Leksell gamma knife is a device enabling to deliver focused radiation toward the intracranial volume ... | ['Brain', 'Humans', 'Neurosurgery', 'Radiosurgery'] | 7,553,754 | [['A08.186.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.810.425'], ['E02.815.530', 'E04.525.800.650', 'E05.873.500']] | ['Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The therapeutic effects of cholecystokinin octapeptide on rat liver and kidney microcirculation disorder in endotoxic shock. | OBJECTIVES: Our previous studies demonstrated that pretreatment with cholecystokinin octapeptide (CCK-8) could alleviate endothelial cell injury and reverse abnormal vascular reactivity as well as reduce LPS-induced inflammation cascades, which suggested that CCK-8 plays a potential role in anti-endotoxic shock. The pr... | ['Animals', 'Chemical and Drug Induced Liver Injury', 'Cholecystokinin', 'Kidney', 'Kidney Diseases', 'Lipopolysaccharides', 'Liver', 'Male', 'Microcirculation', 'Oligopeptides', 'Rats', 'Rats, Sprague-Dawley', 'Shock, Septic', 'Sincalide'] | 27,875,906 | [['B01.050'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['D06.472.317.152', 'D12.644.120'], ['A05.810.453'], ['C12.777.419', 'C13.351.968.419'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['A03.620'], ['G09.330.100.645'], ['D12.644.456'], ['B01.050.150.900.649.313.... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
How confident are general dental practitioners in their decision to administer antibiotic prophylaxis? A questionnaire study. | BACKGROUND: Common dental procedures induce bacteremia. To prevent infectious complications from bacteremia in patients with specific medical conditions, antibiotic prophylaxis is considered. Recommendations are often unclear and ambiguous. In a previous study we reported wide variations in general dental practitioners... | ['Adult', 'Antibiotic Prophylaxis', 'Attitude of Health Personnel', 'Bacteremia', 'Chi-Square Distribution', 'Decision Making', 'Dental Care for Chronically Ill', 'Female', 'General Practice, Dental', 'Humans', 'Interviews as Topic', 'Male', 'Middle Aged', "Practice Patterns, Dentists'", 'Surveys and Questionnaires'] | 19,061,525 | [['M01.060.116'], ['E02.319.162.150', 'E02.319.703.150'], ['F01.100.050', 'N05.300.100'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['F02.463.785.373'], ['E06.170.205', 'N02.421.240.190.220'], ['H02.163.34... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Cytosolic mercaptopyruvate sulfurtransferase is evolutionarily related to mitochondrial rhodanese. Striking similarity in active site amino acid sequence and the increase in the mercaptopyruvate sulfurtransferase activity of rhodanese by site-directed mutagenesis. | Rat liver mercaptopyruvate sulfurtransferase (MST) was purified to homogeneity. MST is very similar to rhodanese in physicochemical properties. Further, rhodanese cross-reacts with anti-MST antibody. Both purified authentic MST and expressed rhodanese possess MST and rhodanese activities, although the ratio of rhodanes... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Binding Sites', 'Biological Evolution', 'Blotting, Western', 'Cysteine', 'Cytosol', 'Liver', 'Male', 'Mitochondria', 'Molecular Sequence Data', 'Mutagenesis', 'Rats', 'Rats, Wistar', 'Recombinant Proteins', 'Sequence Analysis', 'Sequence Homology, Amino Acid', 'Speci... | 7,608,189 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['G05.045', 'G16.075'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299',... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Mechanisms regulating skeletal muscle glucose metabolism in sepsis. | Carbohydrate dyshomeostasis is a characteristic feature of sepsis. Sepsis elevates glucose uptake and cellular lactate levels in muscle. The mechanisms responsible for these alterations are unknown. We examined the effects of a chronic, intra-abdominal septic abscess upon glucose uptake, the expression of the insulin r... | ['Animals', 'Glucose', 'Glucose Transporter Type 1', 'Glucose Transporter Type 4', 'Glycogen', 'Male', 'Monosaccharide Transport Proteins', 'Muscle Proteins', 'Muscle, Skeletal', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Receptor, Insulin', 'Sepsis'] | 7,656,063 | [['B01.050'], ['D09.947.875.359.448'], ['D12.776.157.530.500.500.500', 'D12.776.157.530.937.563.500', 'D12.776.543.585.500.500.500', 'D12.776.543.585.937.625.500'], ['D12.776.157.530.500.500.937', 'D12.776.157.530.937.563.937', 'D12.776.543.585.500.500.937', 'D12.776.543.585.937.625.937'], ['D05.750.078.562.388', 'D09.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolation of cerebellar granule cells from neonatal rats. | Cerebellar Granule Cells in Neurotoxicology (Jan Oberdoerster, Aventis Corporation, Research Triangle Park, North Carolina). Cultured neurons allow the researcher to investigate mechanisms of toxicity on a relatively uniform population of cells. Primary cultures of cerebellar granule cells are post-mitotic neurons that... | ['Animals', 'Animals, Newborn', 'Cell Separation', 'Cells, Cultured', 'Cerebellum', 'Cytoplasmic Granules', 'Rats', 'Rats, Sprague-Dawley'] | 23,045,036 | [['B01.050'], ['B01.050.050.282'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251'], ['A08.186.211.132.810.428.200'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tighter precision target required for lactate testing in patients with lactic acidosis. | BACKGROUND: Allowable analytic errors are generally based on biologic variation in normal, healthy subjects. Some analytes like blood lactate have low concentrations in healthy individuals and resultant allowable variation is large when expressed as a coefficient of variation (CV). In Ric?s' compendium of biologic vari... | ['Acidosis, Lactic', 'Blood Chemical Analysis', 'Humans', 'Intensive Care Units', 'Lactic Acid', 'Reference Values'] | 24,399,677 | [['C18.452.076.176.180'], ['E01.370.225.124.100', 'E05.200.124.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['D02.241.511.459.450'], ['E05.978.810']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Alleviating constipation in the elderly improves lower urinary tract symptoms. | BACKGROUND: Constipation and lower urinary tract symptoms (LUTS) very frequently occur in the elderly, and several reports have suggested that dysfunction in either one of these systems may affect the other. Most studies correlating rectal and bladder dysfunction, however, have been carried out in children or young wom... | ['Aged', 'Aged, 80 and over', 'Chronic Disease', 'Constipation', 'Female', 'Humans', 'Male', 'Prospective Studies', 'Surveys and Questionnaires', 'Ultrasonography', 'Urinary Tract', 'Urologic Diseases'] | 11,287,730 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.291.500'], ['C23.888.821.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['E01.370.350.850'], ['A... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Screening mammography and Pap tests among older American women 1996-2000: results from the Health and Retirement Study (HRS) and Asset and Health Dynamics Among the Oldest Old (AHEAD). | BACKGROUND: We wanted to determine the frequency of self-reported receipt of screening mammography and Papanicolaou (Pap) tests in older women and investigate important predictors of utilization, based on 2 national longitudinal surveys.METHODS: This cohort study includes participants from 4 waves (1994-2000) of the He... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Cost-Benefit Analysis', 'Female', 'Health Services for the Aged', 'Humans', 'Longitudinal Studies', 'Mammography', 'Middle Aged', 'Multivariate Analysis', 'Papanicolaou Test', 'Patient Acceptance of Health Care', 'Risk', 'United States', 'Uterine Cervica... | 15,055,410 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['N03.219.151.125'], ['N02.421.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['E01.370.350.700.5... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Immunopathologic features of Staphylococcus epidermidis-induced endophthalmitis in the rat. | PURPOSE: To investigate the clinical, histopathologic and immunologic responses to Staphylococcus epidermidis endophthalmitis in a rat model.METHODS: Experimental rats received an intravitreal injection of viable S. epidermidis (7000 organisms), while control rats received sterile saline. The clinical scores, cellular ... | ['Animals', 'Anterior Eye Segment', 'Antibodies, Bacterial', 'B-Lymphocytes', 'Colony Count, Microbial', 'Endophthalmitis', 'Enzyme-Linked Immunosorbent Assay', 'Epitopes', 'Eye Infections, Bacterial', 'Female', 'Flow Cytometry', 'Rats', 'Rats, Inbred Lew', 'Staphylococcal Infections', 'Staphylococcus epidermidis', 'Te... | 9,330,856 | [['B01.050'], ['A09.371.060'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['E01.370.225.875.220', 'E05.200.875.220'], ['C01.375.265', 'C11.294.265'... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A computational model of stem cell molecular mechanism to maintain tissue homeostasis. | Stem cells, with their capacity to self-renew and to differentiate to more specialized cell types, play a key role to maintain homeostasis in adult tissues. To investigate how, in the dynamic stochastic environment of a tissue, non-genetic diversity and the precise balance between proliferation and differentiation are ... | ['Animals', 'Cell Differentiation', 'Cell Self Renewal', 'Humans', 'Models, Biological', 'Stem Cells'] | 32,730,297 | [['B01.050'], ['G04.152'], ['G04.144.220.235', 'G04.161.750.500.375', 'G05.113.415', 'G07.345.249.410.750.500.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['A11.872']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hearing from parents: the impact of receiving the diagnosis of Williams syndrome in their child. | Healthcare providers often share difficult or life-altering news with their patients yet this challenging and delicate process is frequently met with dissatisfaction by those receiving this news. Articles and guidelines exist to aid providers in sharing diagnoses such as Down syndrome, but relatively few have focused o... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Disabled Children', 'Expressed Emotion', 'Genetic Counseling', 'Health Care Surveys', 'Humans', 'Infant', 'Infant, Newborn', 'Middle Aged', 'Parents', 'Patient Preference', 'Perception', 'Professional-Patient Relations', 'Truth Disclosure', 'United States', 'William... | 23,401,422 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['M01.150.200'], ['F01.829.197'], ['H01.158.273.343.385.500.384', 'N02.421.308.400'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Changes in Transcranial Ultrasound Velocities in Children with Sickle Cell Disease Undergoing Adenotonsillectomy. | Objectives (1) To assess for changes in cerebral blood flow velocity in children with sickle cell disease and obstructive sleep apnea (OSA) following adenotonsillectomy. (2) To determine if clinical factors such as OSA severity affect cerebral blood flow velocity values. Study Design Case series with chart review over ... | ['Adenoidectomy', 'Adolescent', 'Anemia, Sickle Cell', 'Blood Flow Velocity', 'Cerebrovascular Circulation', 'Child', 'Child, Preschool', 'Cohort Studies', 'Female', 'Humans', 'Male', 'Pilot Projects', 'Sleep Apnea, Obstructive', 'Tonsillectomy', 'Ultrasonography, Doppler, Transcranial'] | 29,405,840 | [['E04.580.068'], ['M01.060.057'], ['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['E01.370.370.130', 'G09.330.380.630.080'], ['G09.330.100.159'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.