Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Keratectasia After Presbyopia Treatment With INTRACOR. | PURPOSE: To report a case of keratectasis of a patient underwent INTRACOR presbyopic treatment 5 years ago.METHODS: Case Report.RESULTS: Fifty-eight-year-old gentleman had presented with deteriorating vision in his left eye. He reported undergoing INTRACOR presbyopic treatment in that eye 5 years ago. At presentation, ... | ['Corneal Diseases', 'Corneal Stroma', 'Corneal Topography', 'Humans', 'Keratomileusis, Laser In Situ', 'Male', 'Middle Aged', 'Postoperative Complications', 'Presbyopia', 'Refraction, Ocular', 'Visual Acuity'] | 27,755,289 | [['C11.204'], ['A09.371.060.217.228'], ['E01.370.380.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594.480.750', 'E04.014.520.480.750', 'E04.378.500.750', 'E04.540.825.437.374'], ['M01.060.116.630'], ['C23.550.767'], ['C11.744.786'], ['E01.370.380.850.700', 'G01.590.775', 'G14.760'], ['E01.370.380.850.9... | ['Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A novel phosphoserine motif in the LCMV matrix protein Z regulates the release of infectious virus and defective interfering particles. | We report that the lymphocytic choriomeningitis virus (LCMV) matrix protein, which drives viral budding, is phosphorylated at serine 41 (S41). A recombinant (r)LCMV bearing a phosphomimetic mutation (S41D) was impaired in infectious and defective interfering (DI) particle release, while a non-phosphorylatable mutant (S... | ['Amino Acid Motifs', 'Amino Acid Substitution', 'Defective Viruses', 'Lymphocytic choriomeningitis virus', 'Mutant Proteins', 'Phosphoserine', 'Viral Matrix Proteins', 'Virion'] | 27,421,645 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['E05.393.420.601.035', 'G05.558.109'], ['B04.265'], ['B04.820.480.500.070.100.550'], ['D12.776.602'], ['D12.125.154.800.968', 'D12.125.740.700'], ['D12.776.964.970.880.940'], ['A21.249']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Representation of Ion-Protein Interactions Using the Drude Polarizable Force-Field. | Small metal ions play critical roles in numerous biological processes. Of particular interest is how metalloenzymes are allosterically regulated by the binding of specific ions. Understanding how ion binding affects these biological processes requires atomic models that accurately treat the microscopic interactions wit... | ['Gases', 'Ions', 'Models, Chemical', 'Proteins', 'Solvents', 'Thermodynamics'] | 25,578,354 | [['D01.362'], ['D01.248.497'], ['E05.599.495'], ['D12.776'], ['D27.720.844'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Habitat type-based bioaccumulation and risk assessment of metal and As contamination in earthworms, beetles and woodlice. | The present study investigated the contribution of environmental factors to the accumulation of As, Cd, Cu, Pb and Zn in earthworms, beetles and woodlice, and framed within an exposure assessment of the European hedgehog. Soil and invertebrate samples were collected in three distinct habitat types. Results showed habit... | ['Animals', 'Arsenic', 'Coleoptera', 'Ecosystem', 'Environmental Monitoring', 'Isopoda', 'Metals, Heavy', 'Oligochaeta'] | 19,524,344 | [['B01.050'], ['D01.268.513.249'], ['B01.050.500.131.617.720.500.500.375'], ['G16.500.275.157', 'N06.230.124'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.500.131.365.400'], ['D01.268.556', 'D01.552.544'], ['B01.050.500.091.657']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Beta adrenergic receptor activation attenuates the generation of inositol phosphates in the pregnant rat myometrium. Correlation with inhibition of Ca++ influx, a cAMP-independent mechanism. | In the pregnant rat myometrium, an averaged 30% of inositol phosphate accumulation induced by carbachol and oxytocin was inhibited by oxodipine indicating that a part of receptor-mediated generation of inositol phosphates depended on Ca++ influx through voltage-gated Ca++ channels. In fura-2-loaded cells, carbachol and... | ['Acetylcholine', 'Adrenergic beta-Agonists', 'Animals', 'Calcium', 'Calcium Channel Blockers', 'Calcium Channels', 'Carbachol', 'Cyclic AMP', 'Dihydropyridines', 'Female', 'Inositol Phosphates', 'Ion Channel Gating', 'Isoproterenol', 'Myometrium', 'Oxytocin', 'Pertussis Toxin', 'Potassium Channels', 'Pregnancy', 'Preg... | 8,558,422 | [['D02.092.211.111'], ['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['D02.092.87... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma. | MYEOV and NEGR1 are novel candidate gene targets in neuroblastoma that were identified by chromosomal gain in 11q13 and loss in 1p31, respectively, through single nucleotide polymorphism array analysis. In the present study, to assess the involvement of MYEOV and NEGR1 in the pathogenesis of neuroblastoma, we analyzed ... | ['Cell Adhesion Molecules, Neuronal', 'Cell Line, Tumor', 'Child', 'Child, Preschool', 'Chromosome Aberrations', 'Chromosomes, Human, Pair 1', 'Chromosomes, Human, Pair 11', 'GPI-Linked Proteins', 'Gene Knockdown Techniques', 'Humans', 'Infant', 'Infant, Newborn', 'Neuroblastoma', 'Proto-Oncogene Proteins'] | 21,624,008 | [['D12.776.395.550.200.250', 'D12.776.543.550.200.250', 'D23.050.301.350.250'], ['A11.251.210.190', 'A11.251.860.180'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.210', 'G05.365.590.175'], ['A11.284.187.520.300.235.240', 'G05.360.162.520.300.235.240'], ['A11.284.187.520.300.325.355', 'G05.360.162.520.300.325.355']... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer's disease: a cross-sectional study. | BACKGROUND: Tests sensitive to presymptomatic changes in Alzheimer's disease could be valuable for clinical trials. Accelerated long-term forgetting-during which memory impairment becomes apparent over longer periods than usually assessed, despite normal performance on standard cognitive testing-has been identified in ... | ['Adult', 'Age of Onset', 'Alzheimer Disease', 'Chromosome Aberrations', 'Cohort Studies', 'Correlation of Data', 'Cross-Sectional Studies', 'DNA Mutational Analysis', 'Early Diagnosis', 'Female', 'Genes, Dominant', 'Genetic Carrier Screening', 'Genetic Testing', 'Humans', 'Male', 'Memory, Long-Term', 'Middle Aged', 'N... | 29,413,314 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['C23.550.210', 'G05.365.590.175'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['H01.548.832.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Pharmacokinetics of ivermectin after maternal or fetal intravenous administration in sheep. | In pregnant sheep at 120-130 days of gestational age, a study was undertaken in order to characterize the pharmacokinetics and transplacental exchange of Ivermectin after maternal or fetal intravenous administration. Eight pregnant Suffolk Down sheep of 73.2 +/- 3.7 kg body weight (bw) were surgically prepared in order... | ['Animals', 'Antiparasitic Agents', 'Area Under Curve', 'Chromatography, High Pressure Liquid', 'Female', 'Fetal Blood', 'Fetus', 'Half-Life', 'Injections, Intravenous', 'Ivermectin', 'Maternal-Fetal Exchange', 'Metabolic Clearance Rate', 'Pregnancy', 'Pregnancy, Animal', 'Sheep'] | 19,000,259 | [['B01.050'], ['D27.505.954.122.250'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['E05.196.181.400.300'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['A16.378'], ['G01.910.405'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['D02.540.576.500.997'], ['G08.686.784.769.455'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Naloxone inhibits sulpiride-induced hyperprolactinaemia in man. | In order to evaluate the interaction between the opiate-like peptidergic pathways and the dopaminergic system in modulating prolactin (PRL) secretion, ten normal volunteers were studied according to a double-blind, cross-over, randomized experimental design. A group of five subjects was given a fixed dose of sulpiride ... | ['Adolescent', 'Adult', 'Dose-Response Relationship, Drug', 'Humans', 'Male', 'Naloxone', 'Prolactin', 'Receptors, Dopamine', 'Sulpiride'] | 3,935,458 | [['M01.060.057'], ['M01.060.116'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.577.249.706', 'D03.605.497.750', 'D03.633.400.686.750', 'D04.615.723.795.706'], ['D06.472.699.322.576.773', 'D06.472.699.631.525.525', 'D12.644.548.691.525.525'], ['D12.776.543.750.670.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Randomized open-label [corrected] non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain. | BACKGROUND: Current worldwide clinical practice guidelines recommend acetaminophen as the first option for the treatment of acute low back pain. However, there is no concrete evidence regarding whether acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) is more effective for treating acute low back pain (LBP... | ['Acetaminophen', 'Acute Pain', 'Adult', 'Aged', 'Aged, 80 and over', 'Anti-Inflammatory Agents, Non-Steroidal', 'Equivalence Trials as Topic', 'Female', 'Humans', 'Japan', 'Low Back Pain', 'Male', 'Middle Aged', 'Pain Measurement', 'Phenylpropionates', 'Young Adult'] | 29,503,036 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['C23.888.592.612.081'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['E05.318.372.250.250.365.500.250', 'N05.715.360.330.250.250.365.500.250', 'N06.850.520.450.250.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Intention to relocate to the United States. | OBJECTIVES: To gain insight into family medicine residents' attitudes toward relocating to the United States and to examine factors influencing their decisions.DESIGN: Cross-sectional mailed survey.SETTING: University of Toronto family medicine program.PARTICIPANTS: First- and second-year residents in the academic year... | ['Adult', 'Attitude of Health Personnel', 'Cross-Sectional Studies', 'Decision Making', 'Emigration and Immigration', 'Female', 'Foreign Medical Graduates', 'Humans', 'Internship and Residency', 'Male', 'Motivation', 'Ontario', 'Physicians, Family', 'Surveys and Questionnaires', 'United States'] | 9,303,232 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F02.463.785.373'], ['I01.240.600.525.500', 'N01.224.625.525.500', 'N06.850.505.400.700.525.500'], ['M01.526.407.435', 'M01.526.485.810.390', 'N02.360.810.390'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Inorganic pyrophosphatase crystals from Thermococcus thioreducens for X-ray and neutron diffraction. | Inorganic pyrophosphatase (IPPase) from the archaeon Thermococcus thioreducens was cloned, overexpressed in Escherichia coli, purified and crystallized in restricted geometry, resulting in large crystal volumes exceeding 5 mm3. IPPase is thermally stable and is able to resist denaturation at temperatures above 348 K. O... | ['Archaeal Proteins', 'Crystallization', 'Crystallography, X-Ray', 'Inorganic Pyrophosphatase', 'Neutron Diffraction', 'Thermococcus', 'X-Ray Diffraction'] | 23,192,028 | [['D12.776.090'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D08.811.277.040.600.399', 'D12.776.157.530.450.250.875.487', 'D12.776.543.585.450.250.875.487'], ['E05.196.309.555', 'E05.196.822.650', 'G01.867.650', 'G02.551'], ['B02.200.825.800.800'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of a combined intravenous/intra-arterial approach in octogenarians. | BACKGROUND: Intravenous (IV) alteplase is not currently recommended in octogenarian patients, and the benefit/risk ratio of endovascular (intra-arterial, IA) therapy remains to be determined. The aim of this study was to determine the impact of a combined IV-IA approach in octogenarians.METHODS: From a single-centre in... | ['Acute Disease', 'Adult', 'Age Factors', 'Aged, 80 and over', 'Brain Ischemia', 'Female', 'Fibrinolytic Agents', 'Humans', 'Injections, Intra-Arterial', 'Injections, Intravenous', 'Male', 'Middle Aged', 'Registries', 'Risk Factors', 'Stroke', 'Thrombolytic Therapy', 'Tissue Plasminogen Activator', 'Treatment Outcome'] | 21,487,220 | [['C23.550.291.125'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100.080'], ['C10.228.140.300.150', 'C14.907.253.092'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.370'], ['E02.319.267.082.750', 'E0... | ['Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Aerophagia due to noninvasive mechanical ventilation: a first manifestation of silent gastric carcinoma]. | Noninvasive mechanical ventilation (NIV) techniques have proven useful in treating patients with respiratory insufficiency of various etiologies. The problems most frequently associated with this ventilatory technique are the appearance of nasal and oropharyngeal dryness, pressure sores where the nasal mask touches the... | ['Aerophagy', 'Humans', 'Male', 'Middle Aged', 'Respiration, Artificial', 'Stomach Neoplasms'] | 12,846,962 | [['C23.888.821.061'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.041.625', 'E02.365.647.729', 'E02.880.820'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hydrophobic moments of protein structures: spatially profiling the distribution. | It is generally accepted that globular proteins fold with a hydrophobic core and a hydrophilic exterior. Might the spatial distribution of amino acid hydrophobicity exhibit common features? The hydrophobic profile detailing this distribution from the protein interior to exterior has been examined for 30 relatively dive... | ['Amino Acids', 'Computational Biology', 'Consensus Sequence', 'Databases as Topic', 'Models, Molecular', 'Protein Folding', 'Protein Structure, Tertiary', 'Protein Subunits', 'Proteins', 'Reproducibility of Results', 'Ribosomes', 'Static Electricity', 'Surface Properties'] | 11,309,489 | [['D12.125'], ['H01.158.273.180', 'L01.313.124'], ['G02.111.570.580.175'], ['L01.313.500.750.300.188', 'L01.470.750'], ['E05.599.595'], ['G01.154.651', 'G02.111.688'], ['G02.111.570.820.709.610'], ['D12.776.813'], ['D12.776'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['A11.284.4... | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Energy efficiency drives the global seasonal distribution of birds. | The uneven distribution of biodiversity on Earth is one of the most general and puzzling patterns in ecology. Many hypotheses have been proposed to explain it, based on evolutionary processes or on constraints related to geography and energy. However, previous studies investigating these hypotheses have been largely de... | ['Animal Distribution', 'Animals', 'Birds', 'Energy Intake', 'Energy Metabolism', 'Models, Biological', 'Seasons'] | 29,735,990 | [['F01.145.113.069', 'G16.049'], ['B01.050'], ['B01.050.150.900.248'], ['G07.203.650.240.340'], ['G03.295'], ['E05.599.395'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Can chronic exposure to imidacloprid, clothianidin, and thiamethoxam mixtures exert greater than additive toxicity in Chironomus dilutus? | Widespread agricultural use of neonicotinoid insecticides has resulted in frequent detection of mixtures of these compounds in global surface waters. Recent evidence suggests that neonicotinoid mixtures can elicit synergistic toxicity in aquatic insects under acute exposure conditions, however this has not been validat... | ['Animals', 'Chironomidae', 'Female', 'Guanidines', 'Insecticides', 'Male', 'Neonicotinoids', 'Nitro Compounds', 'Oxazines', 'Thiamethoxam', 'Thiazoles', 'Toxicity Tests, Chronic', 'Water Quality'] | 29,573,726 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.712.500.750'], ['D02.078.370'], ['D27.720.031.700.491', 'D27.888.723.491'], ['D03.383.464'], ['D02.640'], ['D03.383.533'], ['D02.640.910', 'D02.886.675.884', 'D03.383.129.708.884', 'D03.383.464.500', 'D03.383.533.820'], ['D02.886.675', 'D03.383.129.708'], ['E05.940.80... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Antibiotic Use in Cold and Flu Season and Prescribing Quality: A Retrospective Cohort Study. | BACKGROUND: Excessive antibiotic use in cold and flu season is costly and contributes to antibiotic resistance. The study objective was to develop an index of excessive antibiotic use in cold and flu season and determine its correlation with other indicators of prescribing quality.METHODS AND FINDINGS: We included Medi... | ['Adrenergic beta-Antagonists', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Drug Utilization', 'Female', 'Humans', 'Influenza, Human', 'Linear Models', 'Male', 'Medicare', 'Myocardial Infarction', "Practice Patterns, Physicians'", 'Retrospective Studies', 'Seasons', 'Sex Factors', 'Socioeconom... | 26,569,644 | [['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['N04.452.706.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.748.310', 'C01.925.782.620.365', 'C08.730.310'], ['E05.318.740.500.5... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Drosophila P transposons of the urochordata Ciona intestinalis. | P transposons belong to the eukaryotic DNA transposons, which are transposed by a cut and paste mechanism using a P-element-coded transposase. They have been detected in Drosophila, and reside as single copies and stable homologous sequences in many vertebrate species. We present the P elements Pcin1, Pcin2 and Pcin3 f... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Ciona intestinalis', 'Computational Biology', 'DNA Transposable Elements', 'Drosophila', 'Gene Library', 'Molecular Sequence Data', 'Sequence Homology, Amino Acid', 'Sequence Homology, Nucleic Acid'] | 19,424,726 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.150.200.727.150.500', 'B01.050.500.272.727.150.500'], ['H01.158.273.180', 'L01.313.124'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Relationships among body composition, muscle strength, and sarcopenia in esophageal squamous cell carcinoma patients. | PURPOSE: Relationships among body composition indices assessed by various modalities remain to be addressed in patients with esophageal squamous cell carcinoma (ESCC), in whom being underweight is more strikingly prevalent than in those with other malignancies. We investigated the relationships of body composition para... | ['Adult', 'Aged', 'Aged, 80 and over', 'Body Composition', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Muscle Strength', 'Prospective Studies', 'Quality of Life', 'Sarcopenia', 'Surveys and Questionnaires'] | 31,729,568 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['M01.060.116.630'], ['E01.370.600.425', 'G11.427.560'], ['E05.318.372.50... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Neurosteroid dehydroepiandrosterone improves active avoidance retrieval and induces antidepressant-like behavior in rats. | Various studies reported beneficial effects of dehydroepiandrosterone (DHEA) and its sulphate (DHEAS), the neurosteroids involved in various brain functions, on synaptic plasticity, neuronal survival, memory, learning and behavior. This study aimed to investigate the behavioral profile of acute DHEA treatment by using ... | ['Animals', 'Antidepressive Agents', 'Avoidance Learning', 'Behavior, Animal', 'Dehydroepiandrosterone', 'Depression', 'Male', 'Mental Recall', 'Motor Activity', 'Rats, Wistar', 'Retention, Psychology'] | 28,893,591 | [['B01.050'], ['D27.505.954.427.700.122'], ['F02.463.425.097', 'F02.463.785.373.173'], ['F01.145.113'], ['D04.210.500.054.079.429.625', 'D04.210.500.578.502.400', 'D06.472.040.502.400', 'D06.472.334.851.968.952'], ['F01.145.126.350'], ['F02.463.425.540.641'], ['F01.145.632', 'G11.427.410.698'], ['B01.050.150.900.649.31... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Unexpected inorganic elements in oral lesions: results of X-ray energy spectroscopy (XES) on particulate matter in paraffin sections. | X-ray energy spectroscopy (XES) of all particulate matter found by light microscopy in histological sections of 222 oral lesions revealed a much wider range of elements than expected from dental amalgam. Subsequent XES of a variety of endodontic materials, impression materials and toothpastes indicated possible sources... | ['Barium Sulfate', 'Cysts', 'Dental Amalgam', 'Dental Impression Materials', 'Dental Materials', 'Elements', 'Granuloma', 'Humans', 'Mouth Diseases', 'Spectrum Analysis', 'Toothpastes'] | 6,491,833 | [['D01.103.075', 'D01.875.800.800.850.075'], ['C04.182', 'C23.300.306'], ['D25.339.208.291', 'J01.637.051.339.208.291'], ['D25.339.334', 'J01.637.051.339.334'], ['D25.339', 'D27.720.102.339', 'J01.637.051.339'], ['D01.268'], ['C15.604.515.292', 'C23.550.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C07.465'... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effect of radiotherapy on activity and concentration of serum paraoxonase-1 in breast cancer patients. | Paraoxonase-1 (PON1) is an intra-cellular antioxidant enzyme found also in the circulation associated with high-density lipoproteins. The activity of this enzyme has been shown to be decreased in breast cancer (BC) patients. The aims of our study were to investigate the changes produced by radiotherapy (RT) on activity... | ['Adult', 'Aged', 'Aged, 80 and over', 'Aryldialkylphosphatase', 'Breast Neoplasms', 'Female', 'Gene Frequency', 'Genotype', 'Humans', 'Linear Models', 'Middle Aged', 'Neoplasm Metastasis', 'ROC Curve'] | 29,176,871 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D08.811.277.352.660.500'], ['C04.588.180', 'C17.800.090.500'], ['G05.330'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.46... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
How do antibodies and lectins recognize histo-blood group antigens? A 3D-QSAR study by comparative molecular field analysis (CoMFA). | The cross-reaction patterns of nine antibodies and three lectins against 12 H type 2 related oligosaccharides have been analysed by means of 3D-QSAR study. Three-dimensional descriptors of the molecular properties have been used in comparative molecular field analysis (CoMFA). Three different alignments were considered... | ['Antibodies', 'Antigen-Antibody Reactions', 'Antigens', 'Blood Group Antigens', 'Lectins', 'Static Electricity', 'Structure-Activity Relationship'] | 9,007,281 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['G12.122'], ['D23.050'], ['D23.050.301.290', 'D23.050.705.230'], ['D12.776.503'], ['G01.358.500.249.820'], ['G02.111.830', 'G07.690.773.997']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oxitropium bromide (Ba 253), an advance in the field of anticholinergic bronchodilating treatments. Preliminary results. | The changes in FEV1 and in specific conductance induced by 200 micrograms oxitropium bromide given as pressurized aerosol were measured at 8 time intervals during 7 hours after inhalation in a group of 19 patients with reversible broncho-obstruction. The working of the drug was compared to the functional values observe... | ['Adrenergic beta-Agonists', 'Adult', 'Asthma', 'Blood Pressure', 'Bronchitis', 'Bronchodilator Agents', 'Fenoterol', 'Forced Expiratory Volume', 'Humans', 'Ipratropium', 'Male', 'Placebos', 'Scopolamine Derivatives', 'Time Factors'] | 45,210 | [['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C01.748.099', 'C08.127.446', 'C08.381.495.146', 'C08.730.099'], ['D27.505.696.663.050.110', 'D27.505.954.796.050.100']... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Diversity of polyubiquitin chains. | Polyubiquitin chains linked through different lysines of ubiquitin may exert both proteasome-dependent and -independent functions. In a recent Cell issue, Xu et al. employ quantitative proteomics to profile polyubiquitin linkages in yeast. They find that linkages through all lysines of ubiquitin, except lysine-63, can ... | ['Lysine', 'Polyubiquitin', 'Proteasome Endopeptidase Complex', 'Protein Processing, Post-Translational', 'Saccharomyces cerevisiae', 'Ubiquitination'] | 19,386,255 | [['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['D12.776.947.500.500'], ['D05.500.562.500', 'D08.811.277.656.918', 'D08.811.600.730'], ['G02.111.660.871.790.600', 'G02.111.691.600', 'G03.734.871.790.600', 'G05.308.670.600'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['G02.111.660.871.790.600.925'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phenotypic variation of familial hypertrophic cardiomyopathy caused by the Phe(110)-->Ile mutation in cardiac troponin T. | Mutation of the cardiac troponin T (cTnT) gene is a genetic determinant of familial hypertrophic cardiomyopathy (HCM). A Japanese family of 14 individuals, including 6 with HCM, was subjected to genetic and clinical assessment. Five exons of the cTnT gene were sequenced in all family members. A heterozygous or homozygo... | ['Adolescent', 'Adult', 'Aged', 'Cardiomyopathy, Hypertrophic', 'Child', 'DNA', 'DNA Mutational Analysis', 'Female', 'Gene Dosage', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Myocardium', 'Pedigree', 'Point Mutation', 'Polymerase Chain Reaction', 'Troponin T'] | 10,965,086 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C14.280.238.100', 'C14.280.484.048.750.070.160'], ['M01.060.406'], ['D13.444.308'], ['E05.393.760.700.300'], ['G05.380.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['M01.060.116.630'], ['A02.633.580', 'A07.541.704',... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Classification of common functional loops of kinase super-families. | A structural classification of loops has been obtained from a set of 141 protein structures classified as kinases. A total of 1813 loops was classified into 133 subclasses (9 betabeta(links), 15 betabeta(hairpins), 31 alpha-alpha, 46 alpha-beta and 32 beta-alpha). Functional information and specific features relating s... | ['Amino Acid Motifs', 'Catalytic Domain', 'Databases, Protein', 'Models, Chemical', 'Phosphotransferases', 'Protein Kinases', 'Protein Structure, Secondary', 'Protein Structure, Tertiary', 'Structural Homology, Protein', 'Structure-Activity Relationship'] | 15,229,886 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['E05.599.495'], ['D08.811.913.696'], ['D08.811.913.696.620.6... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Immunohistochemical localization of type-II (AT2) angiotensin receptors with a polyclonal antibody against a peptide from the C-terminal tail. | A polyclonal antibody has been prepared against a synthetic peptide derived from the C-terminal tail of the cloned rat AT2 angiotensin receptor, corresponding to amino acid residue 341-351. The antibody was of high titer and displayed monospecific activity toward the synthetic peptide in the ELISA assay. Western blot a... | ['Adrenal Glands', 'Angiotensin II', 'Animals', 'Antibodies', 'Antibody Specificity', 'Enzyme-Linked Immunosorbent Assay', 'Immunohistochemistry', 'Peptide Fragments', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Angiotensin'] | 9,250,577 | [['A06.300.071'], ['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['G12.100'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevention of endemic goitre with iodized salt. | The paper describes a study, carried out over 16 years, of the use of iodized salt for the control of endemic goitre in a valley of the Himalayan foothills. From 1956, salt was fortified with either potassium iodide or potassium iodate to provide an estimated daily intake of 200 mug per head. There was a progressive an... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Food, Fortified', 'Goiter, Endemic', 'Humans', 'India', 'Infant', 'Iodates', 'Iodine', 'Male', 'Potassium', 'Potassium Iodide', 'Sodium Chloride'] | 4,546,523 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['G07.203.300.515', 'J02.500.515'], ['C19.874.283.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['M01.060.703'], ['D01.248.497.158.480', 'D01.475.400'], ['D01.268.380.400'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', '... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 |
Bilirubin inhibits calcium carbonate precipitation in gallbladder bile. | BACKGROUND: Previous studies have shown that human bile contains one or more factors that inhibit the precipitation of calcium carbonate from supersaturated solutions of calcium chloride and sodium bicarbonate. Lower concentrations of this factor have been observed in the gallbladder bile of patients with calcified gal... | ['Bile', 'Bilirubin', 'Calcium Carbonate', 'Chemical Precipitation', 'Cholelithiasis', 'Humans', 'Hydrogen-Ion Concentration'] | 7,652,689 | [['A12.200.087'], ['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['D01.146.275', 'D01.200.275.150.150', 'D01.578.200'], ['E05.196.150', 'G02.159'], ['C06.130.409'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The contribution of glucose cycling to the maintenance of steady-state levels of lactate by hepatocytes during glycolysis and gluconeogenesis. | When hepatocytes from fasted rats were incubated with 10 mM glucose, there was a linear accumulation of lactate and pyruvate for about 80 min after which steady-state concentrations of these metabolites became established. The rate of glycolysis, determined with [6-3H]glucose, was constant over the entire incubation pe... | ['Animals', 'Gluconeogenesis', 'Glucose', 'Glycolysis', 'Lactates', 'Lactic Acid', 'Liver', 'Male', 'Rats', 'Rats, Wistar'] | 7,851,408 | [['B01.050'], ['G02.111.158.500', 'G03.191.500'], ['D09.947.875.359.448'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['D02.241.511.459'], ['D02.241.511.459.450'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metal-Organic Synthetic Transporters (MOST): Efficient Chloride and Antibiotic Transmembrane Transporters. | We present the synthesis of two functionalized 2,4,7-triphenylbenzimidazole ligands and demonstrate the formation of their respective metal assemblies in phospholipid membranes. Anion transport experiments demonstrate the formation of metal-organic synthetic transporters (MOST) directly in phospholipid membranes. The f... | ['Anti-Bacterial Agents', 'Bacillus thuringiensis', 'Chlorides', 'Coordination Complexes', 'Drug Resistance, Bacterial', 'Liposomes', 'Metal-Organic Frameworks', 'Microbial Sensitivity Tests', 'Palladium', 'Phospholipids', 'Spectrophotometry', 'Tetracycline'] | 28,252,814 | [['D27.505.954.122.085'], ['B03.300.390.400.158.218.800', 'B03.353.500.100.218.800', 'B03.510.100.100.218.800', 'B03.510.415.400.158.218.800', 'B03.510.460.410.158.218.800'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D01.234', 'D02.257'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['D25.479.517', 'D... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Enhanced detection of bladder cancer using the epithelial surface marker epithelial membrane antigen: a preliminary report. | The flow cytometry (FCM) technique allows for the rapid quantitative analysis of the DNA content of individual cells. In a variety of genitourinary tumors, DNA ploidy has a significant impact upon prognosis and ultimate patient survival. In patients having transitional cell cancer (TCC) of the bladder, FCM of voided ur... | ['Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Antibodies, Monoclonal', 'Antigens, Neoplasm', 'Biomarkers, Tumor', 'Carcinoma, Transitional Cell', 'Cystoscopy', 'Diagnosis, Differential', 'Flow Cytometry', 'Humans', 'Membrane Glycoproteins', 'Middle Aged', 'Mucin-1', 'Multivariate Analysis', 'Urinary Bladder Ne... | 2,074,517 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.285'], ['D23.101.140'], ['C04.557.470.200.430'], ['E01.370.388.250.180', 'E01.370.390.175', 'E04.502.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[When is a tall child too tall?]. | 3 children presented with tall stature. A 14-year-old girl of 179.6 cm was found to be within her target height range and was treated with oestrogen. A 15.5-year-old boy of 199,5 cm was beyond his target height range and was found to have a 47,XYY karyo- type; growth was inhibited with epiphysiodesis. A 12-year-old gir... | ['Adolescent', 'Body Height', 'Bone Development', 'Child', 'Contraindications', 'Diagnosis, Differential', 'Female', 'Gonadal Steroid Hormones', 'Growth Disorders', 'Humans', 'Male', 'XYY Karyotype'] | 15,909,388 | [['M01.060.057'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['G07.345.500.325.377.625.050.500', 'G11.427.578.050.500'], ['M01.060.406'], ['E02.208'], ['E01.171'], ['D06.472.334.851'], ['C23.550.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity. | Angiogenesis is a tightly controlled process in which signaling by the receptors for vascular endothelial growth factor (VEGF) plays a key role. In order to define signaling pathways downstream of VEGF receptors (VEGFR), the kinase domain of VEGFR2 (Flk-1) was used as a bait to screen a human fetal heart library in the... | ['Animals', 'Aorta', 'Cells, Cultured', 'Endothelial Growth Factors', 'Humans', 'Lymphokines', 'Neovascularization, Physiologic', 'Phosphorylation', 'Protein Tyrosine Phosphatases', 'Rats', 'Receptor Protein-Tyrosine Kinases', 'Receptors, Growth Factor', 'Receptors, Vascular Endothelial Growth Factor', 'Recombinant Pro... | 10,608,891 | [['B01.050'], ['A07.015.114.056'], ['A11.251'], ['D12.644.276.390', 'D12.776.467.390', 'D23.529.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.480', 'D12.776.467.374.480', 'D23.529.374.480'], ['G09.330.630'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D08.811.277.352.650.775'], ['B01.050.15... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Primary epithelioid angiosarcoma of the adrenal gland. | Primary angiosarcomas of the adrenal gland are exceptionally rare vascular tumors. We report a case of a 63-year-old man with an epithelioid angiosarcoma of the left adrenal gland. Visualized on computed tomography as a nonhomogeneous round mass, the tumor measured 3 cm in diameter. Histology showed a vascular tumor co... | ['Adenoma', 'Adrenal Gland Neoplasms', 'Biomarkers, Tumor', 'Carcinoma', 'Diagnosis, Differential', 'Epithelioid Cells', 'Hemangiosarcoma', 'Humans', 'Male', 'Melanoma', 'Middle Aged', 'Pheochromocytoma', 'Tomography, X-Ray Computed'] | 11,598,858 | [['C04.557.470.035'], ['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['D23.101.140'], ['C04.557.470.200'], ['E01.171'], ['A11.329.372.300', 'A11.627.482.300', 'A11.733.397.300', 'A15.382.670.522.300', 'A15.382.680.397.300'], ['C04.557.450.795.390', 'C04.557.645.390'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors. | In the present study, the ability of 5-hydroxytryptamine(2C) (5-HT(2C)) receptors in the hippocampus to enhance locomotor activity in rats was investigated by local infusion. Intraperitoneal injection of the selective 5-HT(2C) antagonist SB 242084 (1 mg/kg) significantly increased rats motor activity, while the effects... | ['Aminopyridines', 'Animals', 'Circadian Rhythm', 'Drug Administration Routes', 'Hippocampus', 'Indoles', 'Injections, Intraperitoneal', 'Male', 'Motor Activity', 'Neural Pathways', 'Neurons', 'Piperazines', 'Rats', 'Rats, Wistar', 'Receptor, Serotonin, 5-HT2C', 'Receptors, Serotonin', 'Serotonin', 'Serotonin Antagonis... | 11,311,410 | [['D02.092.080', 'D03.383.725.050'], ['B01.050'], ['G07.180.562.190'], ['E02.319.267'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['D03.633.100.473'], ['E02.319.267.530.490'], ['F01.145.632', 'G11.427.410.698'], ['A08.612'], ['A08.675', 'A11.671'], ['D03.383.606'], ['B01.050.150.900.649.313.992.635.50... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Provocation of massive hepatic necrosis by endotoxin after partial hepatectomy in rats. | When rats received endotoxin 48 hours after two-thirds liver resection, 50% of them died within 12 hours with massive hepatic necrosis at a dose that did not affect sham-operated rats. In the hepatic sinusoids, fibrin deposition and endothelial cell destruction occurred 5 hours after endotoxin administration. When anti... | ['Animals', 'Endotoxins', 'Fibrin', 'Formazans', 'Hepatectomy', 'Kupffer Cells', 'Liver', 'Liver Function Tests', 'Male', 'Necrosis', 'Rats', 'Rats, Inbred Strains'] | 2,379,781 | [['B01.050'], ['D23.946.123.329'], ['D12.776.124.270'], ['D02.172.600'], ['E04.210.556'], ['A11.329.372.588', 'A11.627.482.588', 'A11.733.397.588', 'A15.382.670.522.588', 'A15.382.680.397.588'], ['A03.620'], ['E01.370.372.460'], ['C23.550.717'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Displaced granulosa cells in the fallopian tube mistaken for metastatic granulosa cell tumor. | A 44-yr-old woman underwent a total hysterectomy and bilateral salpingectomy secondary to uterine leiomyomas. Gross examination of the fallopian tubes revealed no masses or lesions; however, 2 small foci of granulosa cells were identified microscopically within one of the fallopian tubes. These foci were suspicious for... | ['Adult', 'Choristoma', 'Diagnostic Errors', 'Fallopian Tube Diseases', 'Female', 'Granulosa Cell Tumor', 'Granulosa Cells', 'Humans', 'Hysterectomy', 'Leiomyoma', 'Salpingectomy', 'Uterine Neoplasms'] | 23,202,782 | [['M01.060.116'], ['C23.300.250'], ['E01.354', 'N02.421.450.280'], ['C13.351.500.056.390'], ['C04.557.475.750.656', 'C04.588.322.455.398', 'C13.351.500.056.630.705.398', 'C13.351.937.418.685.398', 'C19.344.410.398', 'C19.391.630.705.398'], ['A05.360.319.114.630.535.200', 'A06.300.312.497.535.300', 'A11.382.812', 'A11.4... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Timing of radiation therapy, lymph node retrieval, and survival in rectal cancer. | BACKGROUND: Lymph node retrieval is an independent prognostic factor for survival in rectal cancer. Preoperative radiotherapy has been shown to impact the number of lymph nodes retrieved.OBJECTIVE: This study aimed to analyze colorectal cancer-specific mortality and overall mortality associated with the number of lymph... | ['Adolescent', 'Adult', 'Aged', 'California', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Infant, Newborn', 'Lymph Node Excision', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Prognosis', 'Rectal Neoplasms', 'Retrospective Studies', 'Survival Rate', 'Time Fact... | 21,471,752 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
MR imaging in the morphologic diagnosis of congenital heart disease. | The ability of magnetic resonance (MR) imaging to depict cardiovascular structures is especially useful in patients with congenital heart disease (CHD). While MR imaging techniques that focus on cardiac function or blood flow have not been used frequently in the evaluation of CHD, MR imaging has been useful in morpholo... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Heart Defects, Congenital', 'Humans', 'Infant', 'Infant, Newborn', 'Magnetic Resonance Imaging', 'Radionuclide Imaging'] | 9,084,081 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E01.370.350.825.500'], ['E01.370.350.710', 'E01.370.384.730']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Design, screening and antimicrobial activity of novel peptides against Streptococcus mutans | OBJECTIVE: To construct antimicrobial peptides with potent antimicrobial activity, low cytotoxicity and efficient killing rate of Streptococcus mutans for prevention and treatment of dental caries.METHODS: We exploited the existing design strategies to modify reutericin 6 or gassericin A produced by Lactobacillus speci... | ['Anti-Infective Agents', 'Dental Caries', 'Humans', 'Microbial Sensitivity Tests', 'Peptides', 'Streptococcus mutans'] | 31,340,916 | [['D27.505.954.122'], ['C07.793.720.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['D12.644'], ['B03.353.750.737.872.875.520', 'B03.510.400.800.872.875.520', 'B03.510.550.737.872.875.520']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension. | Calcium sensitization mediated by RhoA/Rho kinase pathway can be evaluated either in the absence (basal calcium sensitization) or in the presence of endogenous vasoconstrictor systems (activated calcium sensitization). Our aim was to compare basal and activated calcium sensitization in three forms of experimental hyper... | ['Animals', 'Animals, Genetically Modified', 'Calcium', 'Humans', 'Hypertension', 'Rats', 'Rats, Inbred Dahl', 'Rats, Inbred SHR', 'Signal Transduction', 'Sympathetic Nervous System', 'Vasoconstriction', 'rho-Associated Kinases'] | 28,197,417 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.165', 'B01.050.150.900.649.313.992.635.505.700.400.165'], ['B01.050.050.199.52... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[In vitro sensitivity of Plasmodium falciparum isolates from Gabon to chloroquine and cycloguanil]. | The in vitro susceptibility of 91 Plasmodium falciparum isolates obtained from malaria-infected children living near Libreville (Gabon) was evaluated against chloroquine and cycloguanil (biologically active metabolite of proguanil), using an isotopic micro-drug susceptibility test. In vitro resistance to chloroquine an... | ['Adolescent', 'Animals', 'Antimalarials', 'Child', 'Child, Preschool', 'Chloroquine', 'Drug Resistance', 'Gabon', 'Humans', 'Infant', 'Malaria, Falciparum', 'Plasmodium falciparum', 'Proguanil', 'Triazines'] | 10,399,596 | [['M01.060.057'], ['B01.050'], ['D27.505.954.122.250.100.085'], ['M01.060.406'], ['M01.060.406.448'], ['D03.633.100.810.050.180'], ['G07.690.773.984'], ['Z01.058.290.100.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C01.610.752.530.650', 'C01.920.875.650'], ['B01.043.075.380.611.561'], ['D0... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Gender disparities in screening for congenital hypothyroidism using thyroxine as a primary screen. | OBJECTIVE: Newborn screening for congenital hypothyroidism (CH) is based on testing for the markers thyroxine (T4) and/or thyroid-stimulating hormone (TSH). Diagnosis of CH is complicated because many factors affect the levels of these hormones including infant birth weight, prematurity and age at specimen collection. ... | ['Congenital Hypothyroidism', 'False Positive Reactions', 'Female', 'Humans', 'Infant, Newborn', 'Male', 'Neonatal Screening', 'Reference Values', 'Sex Characteristics', 'Thyrotropin', 'Thyroxine'] | 29,945,892 | [['C05.116.099.343.347', 'C05.116.132.256', 'C16.320.240.625', 'C19.297.155', 'C19.874.482.281'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E01.370.225.910', 'E01.370.500.580', 'E05.200.910', 'E05.318.308.980.438.580.580', 'N02.421.726.233.443.816', 'N05.715.360.300.800.43... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Multiple recurrent intrapulmonary and endobronchial mesenchymomas (hamartomas). | A patient is described with multiple, benign, chondromatous intrapulmonary and endobronchial mesenchymomas of the lung, which recurred after resection on two occasions over a period of 30 years. In such a patient presenting at a young age or with a history of previous recurrence, a wedge excision may be necessary to pr... | ['Adult', 'Age Factors', 'Bronchial Neoplasms', 'Female', 'Hamartoma Syndrome, Multiple', 'Humans', 'Lung', 'Lung Neoplasms', 'Neoplasm Recurrence, Local', 'Radiography'] | 8,322,250 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C04.588.894.797.520.109', 'C08.127.265', 'C08.785.520.100'], ['C04.445.435', 'C04.651.435', 'C04.700.435', 'C16.320.700.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.697.655', ... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Women's experiences and health care-seeking practices in relation to uterine prolapse in a hill district of Nepal. | BACKGROUND: Although uterine prolapse (UP) occurs commonly in Nepal, little is known about the physical health and care-seeking practices of women with UP. This study aimed to explore women's experiences of UP and its effect on daily life, its perceived causes, and health care-seeking practices.METHODS: Using a conveni... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Marriage', 'Middle Aged', 'Nepal', 'Patient Acceptance of Health Care', 'Personal Autonomy', 'Role', 'Sexual Dysfunction, Physiological', 'Shame', 'Social Stigma', 'Spouses', 'Urinary Incontinence', 'Uterine Prolapse', ... | 24,490,616 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.315.500.500', 'I01.240.361.500.500', 'I01.880.853.150.423.500.500', 'N01.224.361.500.500', 'N01.824.308.500.500'], ['M01.060.116.630'], ['Z01.252.245.674... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Humanities [K]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Enucleations: epidemiologic investigation in Morocco. presentation of 183 cases]. | INTRODUCTION: The authors report the results of an epidemiological study concerning 183 enucleated eyeballs.MATERIAL AND METHODS: [corrected] The study is realized over a 12-year period (1988-2000) in the department of Ophthalmology "B" (University Hospital--Rabat) on 183 enucleated eyes, only 90% having an histologica... | ['Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Eye Diseases', 'Eye Enucleation', 'Eye Injuries', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Morocco', 'Sex Distribution'] | 15,253,488 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C11'], ['E04.540.429'], ['C10.900.300.284.250', 'C11.297', 'C26.915.300.425.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Summary health statistics for the U.S. population: National Health Interview Survey, 2007. | OBJECTIVES: This report presents both age-adjusted and unadjusted health statistics from the 2007 National Health Interview Survey (NHIS) for the civilian noninstitutionalized population of the United States, classified by sex, age, race, Hispanic or Latino origin and race, education, family income, poverty status, hea... | ['Accidents', 'Activities of Daily Living', 'Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Education, Special', 'Female', 'Health Services Accessibility', 'Health Status', 'Health Surveys', 'Hospitalization', 'Humans', 'Infant', 'Infant, Newborn', 'Insurance Coverage', 'Interviews as Topic', 'Male', 'Midd... | 19,275,089 | [['N06.850.135'], ['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['I02.233.213'], ['N04.590.374.350', 'N05.300.430'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['E05.318.308.980.438', 'N0... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Naturalistic stress and cortisol response to awakening: adaptation to seafaring. | Study of the hypothalamic-pituitary adrenal (HPA) axis has been critical to advancing our understanding of human adaptation to stress. The cortisol response to awakening (CRA) is a potentially useful measure for understanding group and individual differences in HPA axis regulation. In this study, the CRA was examined i... | ['Adaptation, Physiological', 'Adolescent', 'Adult', 'Circadian Rhythm', 'Environment', 'Female', 'Humans', 'Hydrocortisone', 'Male', 'Naval Medicine', 'Oceans and Seas', 'Saliva', 'Ships', 'Stress, Physiological', 'Wakefulness'] | 18,657,911 | [['G07.025', 'G16.012.500'], ['M01.060.057'], ['M01.060.116'], ['G07.180.562.190'], ['G16.500.275', 'N06.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['H02.403.560'], ['G01.311.625', 'G16.500.275.725.500.650', 'Z01.756'], ... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 |
Simultaneous quantitative determination of 20 active components in the traditional Chinese medicine formula Zhi-Zi-Da-Huang decoction by liquid chromatography coupled with mass spectrometry: application to study the chemical composition variations in different combinations. | Zhi-Zi-Da-Huang decoction (ZZDHD), a classical traditional Chinese medicine (TCM) prescription composed of four herbal medicines, has been widely used in treating various hepatobiliary disorders for a long time. The objective of this study was to develop a sensitive and efficient liquid chromatography coupled with mass... | ['Chromatography, High Pressure Liquid', 'Drugs, Chinese Herbal', 'Mass Spectrometry', 'Plants, Medicinal'] | 25,678,253 | [['E05.196.181.400.300'], ['D20.215.784.500.350', 'D26.335'], ['E05.196.566'], ['B01.650.560']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rheological properties and microstructure of Cheddar cheese made with different fat contents. | Reduced- and low-fat cheeses are desired based on composition but often fall short on overall quality. One of the major problems with fat reduction in cheese is the development of a firm texture that does not break down during mastication, unlike that observed in full-fat cheeses. The objective of this investigation wa... | ['Animals', 'Cheese', 'Chemical Phenomena', 'Dietary Fats', 'Food Handling', 'Rheology', 'Time Factors'] | 20,854,990 | [['B01.050'], ['G07.203.200.500.444', 'G07.203.300.350.300.444', 'J02.350.500.444', 'J02.500.350.300.444'], ['G02'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['J01.576.423.200'], ['E05.830', 'H01.671.808'], ['G01.910.857']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
A sensitive high-performance liquid chromatographic procedure with fluorometric detection for the analysis of decarboxylated S-adenosylmethionine and analogs in urine samples. | A highly sensitive HPLC method for the determination of decarboxylated S-adenosylmethionine (dc-SAM) by fluorometric detection was developed. The reaction of dc-SAM and its analogs with chloroacetaldehyde leads to the corresponding 1,N6-etheno derivatives. These highly fluorescent derivatives were fully characterized t... | ['Alkynes', 'Animals', 'Chemical Phenomena', 'Chemistry', 'Chromatography, High Pressure Liquid', 'Decarboxylation', 'Diamines', 'Humans', 'Male', 'Ornithine Decarboxylase Inhibitors', 'Rats', 'S-Adenosylmethionine', 'Spectrometry, Fluorescence', 'Spectrophotometry, Ultraviolet'] | 3,728,970 | [['D02.455.326.397'], ['B01.050'], ['G02'], ['H01.181'], ['E05.196.181.400.300'], ['G02.111.195', 'G02.607.188', 'G03.225'], ['D02.092.782.258'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.389.705'], ['B01.050.150.900.649.313.992.635.505.700'], ['D02.886.030.676.180', 'D03.633.100.759.590.138.264', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Transcriptome analysis of beta-lactamase genes in diarrheagenic Escherichia coli. | Beta (â)-lactamases are the most important agents that confer drug resistance among gram-negative bacteria. Continuous mutations in â-lactamases make them remarkably diverse. We carried out the transcriptome analysis of 10 â-lactamase genes of Extended-Spectrum â-lactamases (ESBL), Metallo â-lactamases (MBL), and AmpC ... | ['Anti-Bacterial Agents', 'Child, Preschool', 'Diarrhea', 'Drug Resistance, Microbial', 'Escherichia coli', 'Escherichia coli Infections', 'Gene Expression Profiling', 'Humans', 'Infant', 'Infant, Newborn', 'Transcriptome', 'beta-Lactamases'] | 30,842,518 | [['D27.505.954.122.085'], ['M01.060.406.448'], ['C23.888.821.214'], ['G06.225', 'G07.690.773.984.269'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['G02.111.873.750', 'G05.29... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Amino acid derivatives as bitter taste receptor (T2R) blockers. | In humans, the 25 bitter taste receptors (T2Rs) are activated by hundreds of structurally diverse bitter compounds. However, only five antagonists or bitter blockers are known. In this study, using molecular modeling guided site-directed mutagenesis, we elucidated the ligand-binding pocket of T2R4. We found seven amino... | ['Alanine', 'Amino Acids', 'Asparagine', 'Binding Sites', 'GABA Agents', 'HEK293 Cells', 'Humans', 'Lysine', 'Models, Molecular', 'Molecular Structure', 'Mutation', 'Protein Binding', 'Protein Structure, Tertiary', 'Quinine', 'Receptors, G-Protein-Coupled', 'Taste', 'Threonine', 'gamma-Aminobutyric Acid'] | 25,059,668 | [['D12.125.042'], ['D12.125'], ['D12.125.068.060', 'D12.125.095.165', 'D12.125.154.049'], ['G02.111.570.120'], ['D27.505.519.625.240', 'D27.505.696.577.240'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['E05.599.595... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Paediatric admissions to hospital on Niue Island, 1977-1982. | For the period 1977-1982, hospital records on Niue Island, western Polynesia, reveal that a total of 929 children aged 0 to 15 years were admitted. Just over half (57%) of these children were male. The majority (62%) were under six years of age; one-quarter (25%) were infants. Leading reasons for admission were respira... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Gastrointestinal Diseases', 'Hospitalization', 'Humans', 'Infant', 'Length of Stay', 'Male', 'Morbidity', 'Mortality', 'Polynesia', 'Respiratory Tract Diseases', 'Wounds and Injuries'] | 3,393,335 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C06.405'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E02.760.400.480', 'N02.421.585.400.480'], ['E05.318.308.985.525', 'N01.224.935.597', 'N06.850.505.400.975.525', 'N06.850.520.308.985.525'], ['E05.3... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Second cancer incidence, risk factor, and specific mortality in head and neck squamous cell carcinoma. | OBJECTIVE: Second primary malignancies (SPMs) are common in patients with head and neck squamous cell carcinoma (HNSCC) and have a negative impact on their survival. This study aimed to evaluate risk factors for SPM occurrence and cause-specific mortality in Asian HNSCC patients.STUDY DESIGN: A retrospective cohort stu... | ['Adult', 'Aged', 'Aged, 80 and over', 'Alcohol Drinking', 'Carcinoma, Squamous Cell', 'Female', 'Gastrointestinal Neoplasms', 'Head and Neck Neoplasms', 'Humans', 'Hypopharyngeal Neoplasms', 'Incidence', 'Lung Neoplasms', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasms, Multiple Prim... | 23,820,107 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.145.317.269'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C04.588.274.476', 'C06.301.371', 'C06.405.249'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.665.710.485', 'C07.550.745.436', 'C09.647.710.485', 'C09... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An alternative strategy treated giant congenital melanocytic nevi with epidermis and superficial dermis of the lesions. | Giant congenital melanocytic nevi (GCMN) are defined as rare pigmented lesions that are believed to form between weeks 9 and 20 of gestation. It is difficult to reconstruct large defects after the removal of the lesions and it has posed a great challenge to the plastic surgeon and dermatologist.Given all those difficul... | ['Adolescent', 'Child', 'Dermis', 'Epidermis', 'Feasibility Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Nevus, Pigmented', 'Skin Neoplasms', 'Treatment Outcome'] | 29,369,208 | [['M01.060.057'], ['M01.060.406'], ['A17.815.180'], ['A10.272.497', 'A17.815.250'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.665.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison of linear and nonlinear analysis in estimating the Thomas model parameters for methylene blue adsorption onto natural zeolite in fixed-bed column. | Comparison analysis of linear least square method and nonlinear least square method for estimating the kinetic parameters was made using the experimental column data of methylene blue (MB) adsorption onto zeolite at different flow rates and initial concentration. The data were fitted to Thomas model equations using lin... | ['Adsorption', 'Linear Models', 'Methylene Blue', 'Models, Theoretical', 'Nonlinear Dynamics', 'Water Pollutants, Chemical', 'Water Purification', 'Zeolites'] | 17,223,262 | [['G01.030', 'G02.020'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['D02.886.369.517', 'D03.633.300.783.517'], ['E05.599'], ['E05.599.850', 'H01.548.675'], ['D27.888.284.903.655'], ['N06.... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Multiple-dose pharmacokinetics of peginterferon alfa-2b in patients with renal insufficiency. | AIM: To evaluate the safety, tolerability and multiple-dose pharmacokinetics of pegylated interferon (PEG-IFN) alfa-2b in patients with moderate or severe renal insufficiency and in those with normal renal function.METHODS: In an open-label study, subjects with normal renal function (creatinine clearance >80 ml min(-1)... | ['Adolescent', 'Adult', 'Aged', 'Drug Administration Schedule', 'Female', 'Humans', 'Interferon alpha-2', 'Interferon-alpha', 'Male', 'Metabolic Clearance Rate', 'Middle Aged', 'Polyethylene Glycols', 'Recombinant Proteins', 'Renal Insufficiency'] | 17,555,463 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890.250.500', 'D12.776.467.374.440.890.250.500', 'D23.529.374.440.890.250.500'], ['D12.644.276.374.440.890.250', 'D12.776.467.374.440.890.250', 'D23.529.374.440.890.250'], ['E0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Pentastomid, Raillietiella mottae Almeida, Freire and Lopes, 2008, infecting lizards in an area of caatinga, northeast, Brazil. | Pentastomids can infect the respiratory tract of lizards, causing their death and as a result influencing the population size of hosts. Despite this, studies on rates of pulmonary infection of Brazilian lizards, including those living in Caatinga ecosystems of northeastern Brazil are scarce. Active collections of lizar... | ['Animals', 'Brazil', 'Crustacea', 'Host-Parasite Interactions', 'Lizards', 'Lung Diseases, Parasitic', 'Prevalence', 'Severity of Illness Index'] | 18,660,975 | [['B01.050'], ['Z01.107.757.176'], ['B01.050.500.131.365'], ['G16.527.200.400'], ['B01.050.150.900.833.393'], ['C01.610.582', 'C01.748.450', 'C08.381.517', 'C08.730.450'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['E05.318.308.980.438.475.456.500'... | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
In situ buccal carcinoma in a teenager after hematopoietic stem cell transplantation: A case report. | RATIONALE: Hematopoietic stem cell transplantation (HSCT) is the most effective treatment for the majority of patients who have malignant haemolytic disease. Although the success rate of HSCT has increased, the increasing number of cases suffering from secondary solid malignancies after HSCT has attracted more interest... | ['Adolescent', 'Female', 'Graft vs Host Disease', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Leukemia, Myeloid, Acute', 'Mouth Neoplasms'] | 33,120,791 | [['M01.060.057'], ['C20.452'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275'], ['C04.588.443.591', 'C07.465.530']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Syndrome surveillance of fentanyl-laced heroin outbreaks: Utilization of EMS, Medical Examiner and Poison Center databases. | OBJECTIVE: Describe surveillance data from three existing surveillance systems during an unexpected fentanyl outbreak in a large metropolitan area.METHODS: We performed a retrospective analysis of three data sets: Chicago Fire Department EMS, Cook County Medical Examiner, and Illinois Poison Center. Each included data ... | ['Chicago', 'Coroners and Medical Examiners', 'Cross-Sectional Studies', 'Databases, Factual', 'Disease Outbreaks', 'Drug Contamination', 'Drug Overdose', 'Emergency Medical Services', 'Fentanyl', 'Heroin', 'Humans', 'Illinois', 'Naloxone', 'Narcotic Antagonists', 'Narcotics', 'Poison Control Centers', 'Retrospective S... | 28,506,507 | [['Z01.107.567.875.350.350.200', 'Z01.107.567.875.510.350.200', 'Z01.433.305'], ['M01.526.485.230', 'N02.360.230'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['N06.850.290'], ['N06.850.360'], ['C25.775.383', 'E02.319.306.500.500'],... | ['Geographicals [Z]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Charge-shift strategy for isolation of hemoglobin-carcinogen adducts formed at the beta 93 cysteine sulfhydryl groups. | Qualitative and quantitative analysis of human hemoglobin-carcinogen adducts has potential as a diagnostic tool for estimation of biologically effective levels of carcinogen exposure and for attaining a better understanding of individual susceptibility to chemical carcinogenesis. The purpose of this study was to devise... | ['Aminobiphenyl Compounds', 'Biphenyl Compounds', 'Carcinogens', 'Chromatography, Ion Exchange', 'Cysteine', 'Erythrocytes', 'Ethylmaleimide', 'Hemoglobins', 'Humans', 'Hydrolysis', 'In Vitro Techniques', 'Indicators and Reagents', 'Iodoacetamide', 'Nitroso Compounds', 'Salicylates', 'Spectrophotometry, Ultraviolet', '... | 2,519,727 | [['D02.455.426.559.389.185.060'], ['D02.455.426.559.389.185'], ['D27.888.569.100'], ['E05.196.181.400.383'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D02.241.081.337.502.524.418', 'D02.478.440.418', 'D03.383.129.578.399.418'], ['D... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Olfactory dysfunction in chronic stroke patients. | BACKGROUND: The aim of the study was to investigate odor identification performance in patients one year after hospital admittance due to stroke. Predictors for olfactory dysfunction were investigated as well as self-reported olfactory function and pleasantness of olfactory items.METHODS: A 1-year prospective study was... | ['Aged', 'Chronic Disease', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Olfaction Disorders', 'Stroke'] | 26,459,234 | [['M01.060.116.100'], ['C23.550.291.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.597.751.600', 'C23.888.592.763.550'], ['C10.228.140.300.775', 'C14.907.253.855']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Post hibernational anorexia in captive Mediterranean tortoises (Testudo graeca and Thermanni). | Post hibernational anorexia in captive Mediterranean tortoises is an increasingly recognised condition. It is associated with increased blood urea and low blood glucose concentrations and dehydration. A theory to explain its underlying physiology is presented, based on studies of the seasonal and cyclic variations in t... | ['Animals', 'Anorexia', 'Feeding and Eating Disorders', 'Female', 'Hibernation', 'Male', 'Turtles'] | 3,469,810 | [['B01.050'], ['C23.888.821.108'], ['F03.400'], ['G07.110.232.889.500', 'G07.410.421.889.500', 'G16.012.500.535.889.500'], ['B01.050.150.900.833.848']] | ['Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Serious hepatic complications of selective internal radiation therapy with yttrium-90 microsphere radioembolization for unresectable liver tumors. | AIM: Selective internal radiation therapy with yttrium-90 microsphere radioembolization has been used to treat unresectable liver tumors and its acute toxicity has been well described. Subacute and long-term hepatic complications related to radioembolization however may be underreported in the literature. This retrospe... | ['Adult', 'Embolization, Therapeutic', 'Female', 'Humans', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Radiopharmaceuticals', 'Retrospective Studies', 'Yttrium Radioisotopes'] | 25,135,200 | [['M01.060.116'], ['E02.520.360', 'E02.926.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['M01.060.116.630'], ['D27.505.259.843', 'D27.505.519.871', 'D27.720.470.410.650'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element. | Myofibroblasts are specialized contractile fibroblasts that are critical in wound closure and tissue contracture. Generation of contractile force is correlated with the expression of alpha-smooth muscle actin (alpha-SMA); however, little is known regarding molecular mechanisms that control activation of alpha-SMA in my... | ['Actins', 'Animals', 'Fibroblasts', 'Gene Expression Regulation', 'Genes, Regulator', 'Genes, Reporter', 'Granulation Tissue', 'Introns', 'Male', 'Mice', 'Mice, Transgenic', 'Muscle, Smooth', 'Mutation', 'Myocytes, Smooth Muscle', 'Promoter Regions, Genetic', 'Rats', 'Serum Response Factor', 'Transforming Growth Facto... | 15,855,636 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['A11.329.228'], ['G05.308'], ['G05.360.340.024.340.425'], ['G05.360.340.024.340.435'], ['A10.165.450'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sexuality in piroplasms as revealed by electron microscopy in Babesia microti. | Protozoa of the closely related genera Babesia and Theileria are intraerythrocytic parasites of vertebrates. They have a complex life cycle that includes development in an intermediate vector host, a tick. Whether sexual stages occur in the tick has been a subject of great controversy. The small size of the organism an... | ['Animals', 'Babesia', 'Cell Fusion', 'Cricetinae', 'Microscopy, Electron', 'Organoids', 'Reproduction', 'Ticks'] | 6,574,467 | [['B01.050'], ['B01.043.075.600.580.070'], ['E05.242.307', 'G04.155'], ['B01.050.150.900.649.313.992.635.075.250'], ['E01.370.350.515.402', 'E05.595.402'], ['A10.802'], ['G08.686.784'], ['B01.050.500.131.166.132.832']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nosocomial nontyphoidal salmonellosis after antineoplastic chemotherapy: reactivation of asymptomatic colonization? | An increased frequency of nontyphoidal salmonellosis is well established in cancer patients, but it is unclear whether this represents increased susceptibility to exogenous infection or opportunistic, endogenous reactivation of asymptomatic carriage. In a retrospective study, a simple case definition was used to identi... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Carrier State', 'Cross Infection', 'Disease Susceptibility', 'Female', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Neoplasms', 'Opportunistic Infections', 'Retrospective Studies', 'Salmonella', 'Salmonella Infections'] | 15,605,182 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['N06.850.520.169'], ['C01.248', 'C23.550.291.875.500'], ['C23.550.291.687', 'G07.100.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.116.630'], ['C04'], ['C01.597', 'C01.610.684', 'C01.925.597'], ['E05.318.372.500.500.500', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Testicular niche required for human spermatogonial stem cell expansion. | Prepubertal boys treated with high-dose chemotherapy do not have an established means of fertility preservation because no established in vitro technique exists to expand and mature purified spermatogonial stem cells (SSCs) to functional sperm in humans. In this study, we define and characterize the unique testicular c... | ['Adult', 'Adult Stem Cells', 'Cell Culture Techniques', 'Cell Differentiation', 'Cell Separation', 'Fertility Preservation', 'Flow Cytometry', 'Humans', 'Male', 'Mesenchymal Stem Cells', 'Microscopy, Confocal', 'Spermatogenesis', 'Spermatozoa', 'Stem Cell Niche', 'Testis'] | 25,038,247 | [['M01.060.116'], ['A11.872.040'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.152'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['E02.875.800.625', 'E04.936.537.562', 'E05.820.800.625'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Oscillations in plant membrane transport: model predictions, experimental validation, and physiological implications. | Although oscillations in membrane-transport activity are ubiquitous in plants, the ionic mechanisms of ultradian oscillations in plant cells remain largely unknown, despite much phenomenological data. The physiological role of such oscillations is also the subject of much speculation. Over the last decade, much experim... | ['Adaptation, Physiological', 'Cell Membrane', 'Cell Size', 'Feedback, Physiological', 'Ion Pumps', 'Ion Transport', 'Models, Biological', 'Oscillometry', 'Oxygen', 'Plant Physiological Phenomena', 'Potassium', 'Proton Pumps', 'Sodium Chloride', 'Temperature'] | 16,330,526 | [['G07.025', 'G16.012.500'], ['A11.284.149'], ['G04.325'], ['G07.410.732'], ['D12.776.157.530.450', 'D12.776.543.585.450'], ['G03.143.500'], ['E05.599.395'], ['E05.654'], ['D01.268.185.550', 'D01.362.670'], ['G15'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['D12.776.157.530.450.250.... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Endocervicoscopy and Biopsy to Detect Cervical Intraepithelial Squamous Neoplasia in Nonvisible Squamocolumnar Junction With Unsatisfactory Colposcopy: A Pilot Study. | The aim of this study was to investigate the practical utility of endocervicoscopy and targeted biopsy in high-risk human papilloma virus-positive women with abnormal squamous cells on cervical cytology and unsatisfactory colposcopy with nonvisible squamocolumnar junction. Seventy-seven high-risk human papilloma virus-... | ['Adult', 'Aged', 'Biopsy', 'Cervical Intraepithelial Neoplasia', 'Cervix Uteri', 'Colposcopy', 'Female', 'Humans', 'Immunohistochemistry', 'Middle Aged', 'Neoplasm Grading', 'Neoplasm Staging', 'Pilot Projects', 'Sensitivity and Specificity', 'Young Adult'] | 29,375,019 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C04.557.470.200.240.250'], ['A05.360.319.679.256'], ['E01.370.378.150', 'E01.370.388.250.150', 'E04.502.250.150', 'E04.520.150', 'E04.95... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Arterial remodeling in response to hypertension using a constituent-based model. | Hypertension-induced arterial remodeling has been previously modeled using stress-driven remodeling rate equations in terms of global geometrical adaptation (Rachev A, Stergiopulos N, Meister JJ. Theoretical study of dynamics of arterial wall remodeling in response to changes in blood pressure. J Biomech 29: 635-642, 1... | ['Adaptation, Physiological', 'Animals', 'Arteries', 'Blood Flow Velocity', 'Blood Pressure', 'Collagen', 'Computer Simulation', 'Humans', 'Hypertension', 'Mechanotransduction, Cellular', 'Models, Cardiovascular'] | 17,827,261 | [['G07.025', 'G16.012.500'], ['B01.050'], ['A07.015.114'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D05.750.078.280', 'D12.776.860.300.250'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['G01.154.090.500', 'G02.111.820.580', 'G04.83... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Sialogogic activity in the rat of peptides analogous to [Tyr8]-substance P in which substitutions have been made in the N-terminal amino acids. | In order to elucidate the regulatory roles for salivation of amino acids in positions 1-4 of the N-terminal region of [Tyr8]-substance P (SP), the structure-sialogogic activity correlations of various synthetic octa- to undecapeptides replaced in positions 1-4 of [Tyr8]-SP with each of 19 common amino acids, one by one... | ['Amino Acid Substitution', 'Animals', 'Male', 'Peptide Fragments', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Neurokinin-1', 'Salivary Proteins and Peptides', 'Salivation', 'Secretory Rate', 'Statistics, Nonparametric', 'Stimulation, Chemical', 'Substance P'] | 11,269,865 | [['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['D12.644.541'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['D12.776.543.750.695.862.500', 'D12.776.543.750.720.600.830.500', 'D12.776.543.750.750.555.830.500'], ['D12.644.848', 'D12.776.850'], ['G07.203.650.250.80... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
An Application-based programme to reinforce and maintain lower salt intake (AppSalt) in schoolchildren and their families in China. | INTRODUCTION: Salt intake is very high in China, with ?80% being added by the consumers. It is difficult to reduce salt in such settings. Our previous study (School-based Education programme to reduce Salt(School-EduSalt)) demonstrated that educating schoolchildren, who then instructed their families to reduce the amou... | ['Adult', 'Cardiovascular Diseases', 'Child', 'China', 'Diet', 'Family', 'Female', 'Health Education', 'Humans', 'Male', 'Program Evaluation', 'Randomized Controlled Trials as Topic', 'Risk Factors', 'School Health Services', 'Schools', 'Sodium Chloride, Dietary', 'Sodium, Dietary'] | 31,272,977 | [['M01.060.116'], ['C14'], ['M01.060.406'], ['Z01.252.474.164'], ['G07.203.650.240'], ['F01.829.263', 'I01.880.853.150'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.5... | ['Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity. | The combination of the dehydroabietic acid scaffold with different amino acids resulted in the discovery of a new class of hybrid compounds that targets both planktonic and biofilms bacteria in Staphylococcus aureus strains and are far more potent anti-biofilm agents than conventional antibiotics. Unlike dehydroabietic... | ['Abietanes', 'Anti-Bacterial Agents', 'Biofilms', 'Cell Membrane', 'Dose-Response Relationship, Drug', 'Microbial Sensitivity Tests', 'Plankton', 'Staphylococcus aureus', 'Structure-Activity Relationship'] | 26,241,878 | [['D02.455.426.559.847.723.040', 'D02.455.849.291.040', 'D04.615.723.040'], ['D27.505.954.122.085'], ['A20.593', 'G06.120'], ['A11.284.149'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['B05.080.500'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100',... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The development of a "reduced logMAR" visual acuity chart for use in routine clinical practice. | BACKGROUND/AIMS: The advantages of logMAR acuity data over the Snellen fraction are well known, and yet existing logMAR charts have not been adopted into routine ophthalmic clinical use. As this may be due in part to the time required for a logMAR measurement, this study was performed to determine whether an abbreviate... | ['Aged', 'Aged, 80 and over', 'Benchmarking', 'Equipment Design', 'Female', 'Humans', 'Male', 'Middle Aged', 'Normal Distribution', 'Predictive Value of Tests', 'Reproducibility of Results', 'Time Factors', 'Vision Tests', 'Visual Acuity'] | 11,264,133 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.994.500', 'G17.820.500', 'N05.715.360.750.750.565', 'N06.850.520.830.994.500'],... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Misregulated RNA Pol II C-terminal domain phosphorylation results in apoptosis. | Misregulation of the level of RNA polymerase II carboxyl-terminal domain (CTD) phosphatase, Fcp1, in Drosophila results in high level of caspase-mediated apoptosis. Apoptosis induction by Fcp1 misregulation requires the presence of Drosophila melanogaster (Dm)p53, but occurs without the transcriptional activation of Dm... | ['Animals', 'Animals, Genetically Modified', 'Apoptosis', 'Caspases', 'Chromosomes', 'Drosophila Proteins', 'Drosophila melanogaster', 'Female', 'Humans', 'Male', 'Phosphoprotein Phosphatases', 'Phosphorylation', 'Protein Structure, Tertiary', 'RNA Polymerase II', 'Transgenes', 'Tumor Suppressor Protein p53'] | 19,153,663 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Naturally occurring genetic variation affects Drosophila photoreceptor determination. | The signal transduction pathway controlling determination of the identity of the R7 photoreceptor in the Drosophila eye is shown to harbor high levels of naturally occurring genetic variation. The number of ectopic R7 cells induced by the dosage-sensitive SevS11.1 transgene that encodes a mildly activated form of the S... | ['Animals', 'Animals, Genetically Modified', 'Crosses, Genetic', 'Drosophila', 'Drosophila Proteins', 'ErbB Receptors', 'Eye Proteins', 'Female', 'Genetic Variation', 'Male', 'Membrane Glycoproteins', 'Phenotype', 'Photoreceptor Cells, Invertebrate', 'Protein Kinases', 'Receptor Protein-Tyrosine Kinases', 'Receptors, I... | 9,510,541 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['E05.393.281'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['D12.776.306'], ['G05.365'], ['D12.776.395.550', 'D12.776.543.550'], ['G05.695'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of physician and patient characteristics on adherence to breast cancer screening recommendations. | Identifying physician and patient characteristics is important in implementing effective, targeted strategies to improve breast cancer detection rates through increased screening recommendations and uptake. The purpose of this study was to determine whether Ontario physicians recommend breast screening using mammograph... | ['Adult', 'Aged', 'Breast Neoplasms', 'Female', 'Guideline Adherence', 'Humans', 'Mammography', 'Mass Screening', 'Middle Aged', 'Patient Compliance', 'Physician-Patient Relations', 'Practice Guidelines as Topic', "Practice Patterns, Physicians'", 'Surveys and Questionnaires'] | 18,090,910 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['N04.761.337', 'N05.715.360.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700.500'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.85... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
KPC presence in Pseudomonas aeruginosa has minimal impact on the in vivo efficacy of carbapenem therapy. | While reports of Klebsiella pneumoniae carbapenemase (KPC) production among Pseudomonas aeruginosa strains have emerged from a number of countries worldwide, outcome data are lacking. This is the first report evaluating how KPC production in P. aeruginosa impacts the efficacy of carbapenems by using the murine thigh in... | ['Animals', 'Anti-Bacterial Agents', 'Bacterial Proteins', 'Carbapenems', 'Doripenem', 'Ertapenem', 'Mice', 'Microbial Sensitivity Tests', 'Pseudomonas Infections', 'Pseudomonas aeruginosa', 'beta-Lactam Resistance', 'beta-Lactamases', 'beta-Lactams'] | 23,254,422 | [['B01.050'], ['D27.505.954.122.085'], ['D12.776.097'], ['D02.065.589.099.124', 'D03.633.100.300.124'], ['D02.065.589.099.124.150', 'D03.633.100.300.124.150'], ['D02.065.589.099.124.225', 'D03.633.100.300.124.225'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Elevated intracellular Na+ | Over 25 years ago it was first reported that intracellular chloride levels (Cl-in ) were higher in developing neurons than in maturity. This finding has had significant implications for understanding the excitability of developing networks and recognizing the underlying causes of hyperexcitability associated with disea... | ['Animals', 'Benzofurans', 'Chick Embryo', 'Chickens', 'Chlorides', 'Embryonic Development', 'Ethers, Cyclic', 'Interneurons', 'Intracellular Space', 'Motor Neurons', 'Neurons', 'Patch-Clamp Techniques', 'Sodium', 'Sodium-Potassium-Exchanging ATPase', 'Spinal Cord'] | 28,027,400 | [['B01.050'], ['D03.633.100.127'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D01.210.450.150', 'D01.248.497.158.215'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['D02.355.291', 'D04.345.241'], ['A08.675.358', 'A11.671.358'], ['A10.082.750', 'A11.284.430'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The patient-provider relationship as experienced by a diverse sample of highly adherent HIV-infected people. | Qualitative interviews with 23 HIV-infected people who self-reported high-level adherence to antiretroviral therapy were used to examine the process by which they came to accept their HIV infection and engage in high-level adherence behaviors. A major theme that emerged during data analysis was the importance of the pa... | ['Adult', 'Anti-HIV Agents', 'Antiretroviral Therapy, Highly Active', 'Attitude of Health Personnel', 'Communication', 'Female', 'HIV Infections', 'Humans', 'Interviews as Topic', 'Male', 'Middle Aged', 'Patient Compliance', 'Professional-Patient Relations', 'Qualitative Research', 'Retrospective Studies', 'Self Report... | 23,809,659 | [['M01.060.116'], ['D27.505.954.122.388.077.088'], ['E02.319.310.075'], ['F01.100.050', 'N05.300.100'], ['F01.145.209', 'L01.143'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Pheno... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Bullying and suicidal ideation and behaviors: a meta-analysis. | BACKGROUND AND OBJECTIVES: Over the last decade there has been increased attention to the association between bullying involvement (as a victim, perpetrator, or bully-victim) and suicidal ideation/behaviors. We conducted a meta-analysis to estimate the association between bullying involvement and suicidal ideation and ... | ['Adolescent', 'Bullying', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Precipitating Factors', 'Suicidal Ideation', 'Suicide', 'Suicide, Attempted'] | 25,560,447 | [['M01.060.057'], ['F01.145.126.125.550', 'F01.145.813.213.500', 'I01.880.735.070'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N05.715.350.200.650', 'N06.850.490.625.500'], ['F01.145.126.980.875.149', 'I01.880.735.856.149'], ['F01.145.126.980.875', 'I01.880.735.856'], ['F0... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Echocardiographic Assessment of Mitral Stenosis Orifice Area: A Comparison of a Novel Three-Dimensional Method Versus Conventional Techniques. | BACKGROUND: A comprehensive evaluation of mitral stenosis (MS) severity commonly utilizes two-dimensional (2D) echocardiography techniques. However, the complex three-dimensional (3D) structure of the mitral valve (MV) poses challenges to accurate measurements of its orifice area by 2D imaging modalities. We aimed to a... | ['Adult', 'Echocardiography, Three-Dimensional', 'Echocardiography, Transesophageal', 'Female', 'Humans', 'Image Interpretation, Computer-Assisted', 'Male', 'Mitral Valve Stenosis'] | 28,678,069 | [['M01.060.116'], ['E01.370.350.130.750.230', 'E01.370.350.400.200', 'E01.370.350.850.220.230', 'E01.370.370.380.220.230'], ['E01.370.350.130.750.235', 'E01.370.350.850.220.235', 'E01.370.370.380.220.235'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Direct competitive chemiluminescence immunoassays based on gold-coated magnetic particles for detection of chloramphenicol. | Direct competitive chemiluminescence immunoassays (CLIA) based on gold-coated magnetic nanospheres (Au-MNPs) were developed for rapid analysis of chloramphenicol (CAP). The Au-MNPs were modified with carboxyl groups and amino groups by 11-mercaptoundecanoic acid (MUA) and cysteamine respectively, and then were respecti... | ['Chloramphenicol', 'Gold', 'Immunoassay', 'Luminescence', 'Magnetite Nanoparticles'] | 26,031,849 | [['D02.033.455.706.300', 'D02.455.426.559.389.565.175', 'D02.640.529.175'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['E05.478.566', 'E05.601.470'], ['G01.358.500.505.650.665', 'G01.590.540.665', 'G01.750.250.650.665', 'G01.750.770.578.665'], ['J01.637.512.600.500.144.500']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Investigation of antinuclear antibodies in chronic hepatitis B patients]. | Antinuclear antibodies (ANA) facilitate the diagnosis and evaluation of patients in many systemic autoimmune conditions. Besides, ANA may also be detected in chronic infectious diseases. Although a number of investigations associated with autoantibody positivity in patients with chronic hepatitis C were reported, autoa... | ['Adult', 'Antibodies, Antinuclear', 'Autoantibodies', 'Female', 'Hepatitis B, Chronic', 'Humans', 'Male'] | 30,522,427 | [['M01.060.116'], ['D12.776.124.486.485.114.323.204', 'D12.776.124.790.651.114.323.204', 'D12.776.377.715.548.114.323.204'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440.435.100', 'C06.552.380.350.100', 'C0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
HIV Haplotype Inference Using a Propagating Dirichlet Process Mixture Model. | This paper presents a new computational technique for the identification of HIV haplotypes. HIV tends to generate many potentially drug-resistant mutants within the HIV-infected patient and being able to identify these different mutants is important for efficient drug administration. With the view of identifying the mu... | ['Computational Biology', 'HIV Infections', 'HIV-1', 'Haplotypes', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Sequence Analysis, DNA'] | 26,355,517 | [['H01.158.273.180', 'L01.313.124'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['G05.380.360'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.760.700']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
The histological nature of epulides in dogs. | The histological characteristics of a series of 154 oral tumours with the clinical appearance of epulides in 129 dogs were reviewed. Diagnoses were based on current criteria in human oral pathology and compared with the original diagnoses. The histological findings suggested that the majority of epulides in the dog can... | ['Ameloblastoma', 'Animals', 'Biopsy', 'Calcinosis', 'Carcinoma, Squamous Cell', 'Diagnosis, Differential', 'Dog Diseases', 'Dogs', 'Fibrosis', 'Gingiva', 'Gingival Neoplasms', 'Granuloma, Giant Cell', 'Hyperplasia', 'Odontogenic Tumors', 'Retrospective Studies', 'Sarcoma'] | 1,597,534 | [['C04.557.695.065'], ['B01.050'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C18.452.174.130'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E01.171'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Reflex connections from forearm and hand afferents to shoulder girdle muscles in humans. | Using surface electromyographic recordings from the trapezius and serratus anterior muscles and percutaneous electrical stimulation of the median, ulnar and radial nerves, the reflex connections from forearm and hand afferents to these shoulder girdle muscles have been investigated in normal human subjects. Stimulation... | ['Adult', 'Elbow', 'Electric Stimulation', 'Electromyography', 'Evoked Potentials', 'Female', 'Forearm', 'Hand', 'Humans', 'Male', 'Median Nerve', 'Middle Aged', 'Muscle, Skeletal', 'Radial Nerve', 'Reaction Time', 'Reflex', 'Shoulder', 'Ulnar Nerve', 'Wrist'] | 12,541,138 | [['M01.060.116'], ['A01.378.800.420'], ['E05.723.402'], ['E01.370.405.255', 'E01.370.530.255'], ['G07.265.216.500', 'G11.561.200.500'], ['A01.378.800.585'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.800.720.050.500'], ['M01.060.116.630'], ['A02.633.567', 'A10.690.552.500'], ['A08.8... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lambert-Eaton myasthenic syndrome associated with Sj?gren's syndrome and discoid lupus erythematosus. | A 65-year-old woman with facial erythema and hypergammaglobulinemia developed excessive fatigability. A diagnosis of Lambert-Eaton myasthenic syndrome (LEMS) was made from electrophysiological studies. She had symptoms and laboratory data compatible with probable Sj?gren's syndrome. Skin biopsy revealed the histologica... | ['Aged', 'Biopsy', 'Electrodiagnosis', 'Female', 'Humans', 'Lambert-Eaton Myasthenic Syndrome', 'Lupus Erythematosus, Discoid', 'Sialography', "Sjogren's Syndrome", 'Skin'] | 8,266,032 | [['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.370.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.614.550.500.225', 'C04.730.856.490.225', 'C10.114.656.150', 'C10.574.781.588.22... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Computed tomographic evaluation of maximal diaphragmatic crural thickness. | The purpose of this study is to determine the range of maximal diaphragmatic crural thickness during different phases of respiration and to correlate crural thickness with age and gender. Prospective evaluation of computed tomographic (CT) scans of 200 patients without juxtacrural abnormalities was performed. Maximal s... | ['Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'Diaphragm', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Respiration', 'Sex Factors', 'Tomography, X-Ray Computed'] | 8,045,119 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['A02.633.567.900.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['G09.772.705'], ['N05.715.350.675', 'N06.850.490.875... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Immune factors involved in the cervical immune response in the HIV/HPV co-infection. | AIMS: Immune factors influencing the progression of cervical intraepithelial neoplasia (CIN) to cancer remain poorly defined. This study investigates the expression of RANTES, MIP1alpha, COX1, COX2, STAT3, TGFbetaRI, IL10R, TNFalphaRII and TLR4 in the cervical immune response in HIV/HPV (human papillomavirus) co-infect... | ['Adolescent', 'Adult', 'Antiretroviral Therapy, Highly Active', 'Cervical Intraepithelial Neoplasia', 'Chemokine CCL5', 'Cyclooxygenase 1', 'Disease Progression', 'Female', 'HIV Infections', 'HIV-1', 'Humans', 'Immunoenzyme Techniques', 'Middle Aged', 'Neoplasm Proteins', 'Papillomavirus Infections', 'Uterine Cervical... | 17,483,251 | [['M01.060.057'], ['M01.060.116'], ['E02.319.310.075'], ['C04.557.470.200.240.250'], ['D12.644.276.374.200.110.250', 'D12.776.467.374.200.110.250', 'D23.125.300.110.250', 'D23.469.200.110.250', 'D23.529.374.200.110.250'], ['D08.811.600.720.500'], ['C23.550.291.656'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Mechanism of case processing in the brain: an fMRI study. | In sentence comprehension research, the case system, which is one of the subsystems of the language processing system, has been assumed to play a crucial role in signifying relationships in sentences between noun phrases (NPs) and other elements, such as verbs, prepositions, nouns, and tense. However, so far, less atte... | ['Adult', 'Analysis of Variance', 'Behavior', 'Brain', 'Brain Mapping', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Photic Stimulation', 'Semantics', 'Young Adult'] | 22,808,169 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F01.145'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E05.723.729'], ['L01.559.598.745'], ['M01.060.116.815'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1â production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis. | OBJECTIVE: The concept that intraarticular crystals of uric acid by themselves trigger episodes of painful gouty arthritis is inconsistent with the clinical reality. Patients with large deposits of monosodium urate monohydrate (MSU) crystals (tophi) do not necessarily experience gouty attacks. In fact, it is the excess... | ['Animals', 'Apoptosis Regulatory Proteins', 'Arthritis, Gouty', 'CARD Signaling Adaptor Proteins', 'Caspase 1', 'Cells, Cultured', 'Cytoskeletal Proteins', 'Enzyme-Linked Immunosorbent Assay', 'Fatty Acids', 'Humans', 'Inflammation', 'Interleukin-1beta', 'Knee Joint', 'Leukocytes, Mononuclear', 'Macrophages', 'Male', ... | 20,662,061 | [['B01.050'], ['D12.644.360.075', 'D12.776.476.075'], ['C05.550.114.423.410', 'C05.550.354.500.500', 'C05.799.414.410', 'C16.320.565.798.368.410', 'C18.452.648.798.368.410'], ['D12.644.360.024.131', 'D12.644.360.075.358', 'D12.776.157.057.006', 'D12.776.476.024.139', 'D12.776.476.075.358'], ['D08.811.277.656.262.500.12... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Developing EPIC markers for chalcidoid Hymenoptera from EST and genomic data. | Increasing numbers of phylogeographic studies make comparative inferences about the histories of co-distributed species. Although the aims of such studies are best achieved by jointly analysing sequences from multiple loci in a model-based framework, such data currently exist for few nonmodel systems. We used existing ... | ['Animals', 'DNA', 'DNA Primers', 'Expressed Sequence Tags', 'Ficus', 'Genetics, Population', 'Hymenoptera', 'Introns', 'Molecular Sequence Data', 'Phylogeography', 'Quercus', 'Sequence Analysis, DNA'] | 21,481,210 | [['B01.050'], ['D13.444.308'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.360.340.024.340.137.275'], ['B01.650.940.800.575.912.250.859.937.406.500'], ['H01.158.273.343.335'], ['B01.050.500.131.617.720.500.500.875'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'], ['L01.453.245.667'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Surface plasmon resonance biosensor for direct detection of antibody against Epstein-Barr virus. | This paper describes the direct label-free detection of antibodies against the Epstein-Barr virus (anti-EBNA) using a surface plasmon resonance (SPR) biosensor. The antibody detection was performed using the immunoreaction between anti-EBNA and a respective synthetic peptide (EBNA-1), which was conjugated with bovine s... | ['Antibodies', 'Biosensing Techniques', 'Epstein-Barr Virus Nuclear Antigens', 'Equipment Design', 'Equipment Failure Analysis', 'Herpesvirus 4, Human', 'Immunoassay'] | 16,797,175 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['E05.601.043'], ['D23.050.290.249', 'D23.050.327.300'], ['E05.320'], ['E05.325.192'], ['B04.280.210.400.500.450', 'B04.280.382.400.500.400', 'B04.613.204.500.500.400'], ['E05.478.566', 'E05.601.470']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Selection of a novel DNA aptamer for assay of intracellular interferon-gamma. | Interferon-gamma (IFN-ã) is a glycoprotein generated by lymphocytes that possesses anti-tumor, antiviral and immunomodulatory functions. IFN-ã assays are broadly employed in immunological research and clinical diagnostic tests. Intracellular IFN-ã staining, in particular, is an important immune assay that allows simult... | ['Albumins', 'Aptamers, Nucleotide', 'DNA, Single-Stranded', 'Flow Cytometry', 'Humans', 'Interferon-gamma', 'Leukocytes, Mononuclear', 'Lymphocyte Activation', 'Phenotype', 'Protein Binding', 'T-Lymphocytes'] | 24,849,390 | [['D12.776.034'], ['D13.695.578.424.224'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.4... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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