Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Fragment-based screening of the bromodomain of ATAD2. | Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of... | ['ATPases Associated with Diverse Cellular Activities', 'Adenosine Triphosphatases', 'Antineoplastic Agents', 'Binding Sites', 'Chemistry, Pharmaceutical', 'Crystallography, X-Ray', 'DNA-Binding Proteins', 'Humans', 'Kinetics', 'Ligands', 'Magnetic Resonance Spectroscopy', 'Molecular Conformation', 'Neoplasms', 'Protei... | 25,314,628 | [['D08.811.277.040.013.500', 'D08.811.277.040.025.024', 'D12.776.157.025.750'], ['D08.811.277.040.025'], ['D27.505.954.248'], ['G02.111.570.120'], ['H01.158.703.007', 'H01.181.466'], ['E05.196.309.742.225'], ['D12.776.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D27.720.470.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy. | It is assumed that anti-CTLA-4 antibodies cause tumor rejection by blocking negative signaling from B7-CTLA-4 interactions. Surprisingly, at concentrations considerably higher than plasma levels achieved by clinically effective dosing, the anti-CTLA-4 antibody Ipilimumab blocks neither B7 trans-endocytosis by CTLA-4 no... | ['Animals', 'Antibodies, Blocking', 'Antineoplastic Agents, Immunological', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'CTLA-4 Antigen', 'Female', 'Humans', 'Immunotherapy', 'Ipilimumab', 'Lymphocyte Activation', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Neoplasms', 'T-Lymphocytes, ... | 29,472,691 | [['B01.050'], ['D12.776.124.486.485.114.143', 'D12.776.124.790.651.114.143', 'D12.776.377.715.548.114.143'], ['D27.505.954.248.384'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Etiology of acute otitis media and phenotypic-molecular characterization of Streptococcus pneumoniae isolated from children in Liuzhou, China. | BACKGROUND: The etiology and epidemiology of acute otitis media (AOM) are poorly understood in China. This study aimed to describe the etiology of AOM and the phenotypic and molecular characteristics of AOM-causing Streptococcus pneumoniae (S.pneumoniae) recovered from Chinese children.METHODS: A retrospective study wa... | ['Adolescent', 'Anti-Bacterial Agents', 'Child', 'Child, Preschool', 'China', 'Drug Resistance, Bacterial', 'Female', 'Humans', 'Infant', 'Male', 'Microbial Sensitivity Tests', 'Otitis Media', 'Pneumococcal Infections', 'Pneumococcal Vaccines', 'Prevalence', 'Retrospective Studies', 'Serogroup', 'Streptococcus pneumoni... | 30,770,718 | [['M01.060.057'], ['D27.505.954.122.085'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.252.474.164'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['C09.218.705.663'], ['C01.150... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Proper formulation of viscous dissipation for nonlinear waves in solids. | To model nonlinear viscous dissipative motions in solids, acoustical physicists usually add terms linear in ?, the material time derivative of the Lagrangian strain tensor E, to the elastic stress tensor ó derived from the expansion to the third (sometimes fourth) order of the strain energy density E=E(tr E,tr E(2),tr ... | ['Acoustics', 'Elasticity', 'Motion', 'Nonlinear Dynamics', 'Sound', 'Stress, Mechanical', 'Time Factors', 'Viscosity'] | 23,463,998 | [['H01.671.031'], ['G01.374.590'], ['G01.482'], ['E05.599.850', 'H01.548.675'], ['G01.750.770.776'], ['G01.374.835'], ['G01.910.857'], ['G02.930']] | ['Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Sterilization by gamma radiation impairs the tensile fatigue life of cortical bone by two orders of magnitude. | Cortical bone grafts are utilized frequently for skeletal reconstruction, spinal fusion and tumor surgery. Due to its efficacy and convenience terminal sterilization by gamma radiation is often essential to minimize disease transmission and infection. However, the impairment in the material properties of bone tissue se... | ['Adult', 'Biomechanical Phenomena', 'Bone Transplantation', 'Bone and Bones', 'Fractures, Stress', 'Gamma Rays', 'Humans', 'Male', 'Sterilization'] | 16,140,190 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['A02.835.232', 'A10.165.265'], ['C26.404.437'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.780.200.450.850']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Impact of New-Onset Postoperative Depression on Readmission Outcomes After Surgical Coronary Revascularization. | BACKGROUND: Depression affects between 10% and 40% of cardiac surgery patients and is associated with significantly worse outcomes. The incidence and impact of new-onset depression beyond acute follow-up remain ill-defined. The present study aimed to evaluate the incidence, risk factors, and prognostic implication of d... | ['Aged', 'Coronary Artery Bypass', 'Coronary Artery Disease', 'Depression', 'Female', 'Follow-Up Studies', 'Hospital Mortality', 'Humans', 'Incidence', 'Male', 'Patient Readmission', 'Postoperative Complications', 'Quality of Life', 'Retrospective Studies', 'Risk Factors', 'Time Factors'] | 30,502,287 | [['M01.060.116.100'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['F01.145.126.350'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E05.318.308.985.550.400', 'N01.224.935.698... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Could yeast infections impair recovery from mental illness? A case study using micronutrients and olive leaf extract for the treatment of ADHD and depression. | Micronutrients are increasingly used to treat psychiatric disorders including attention-deficit/hyperactivity disorder (ADHD), mood disorders, stress, and anxiety. However, a number of factors influence optimal response and absorption of nutrients, including the health of the gut, particularly the presence of yeast inf... | ['Attention Deficit Disorder with Hyperactivity', 'Candidiasis, Vulvovaginal', 'Depression', 'Female', 'Humans', 'Micronutrients', 'Olea', 'Plant Extracts', 'Plant Leaves', 'Probiotics', 'Young Adult'] | 23,784,606 | [['F03.625.094.150'], ['C01.150.703.160.190', 'C13.351.500.894.906.820.500', 'C13.351.500.944.902.737.500'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.494', 'G07.203.300.681.500', 'J02.500.681.500'], ['B01.650.940.800.575.912.250.583.640.666'], ['D20.215.784.500', 'D26.667'], [... | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Three-dimensional visualization of nanostructured surfaces and bacterial attachment using Autodesk® Maya®. | There has been a growing interest in understanding the ways in which bacteria interact with nano-structured surfaces. As a result, there is a need for innovative approaches to enable researchers to visualize the biological processes taking place, despite the fact that it is not possible to directly observe these proces... | ['Bacteria', 'Bacterial Adhesion', 'Imaging, Three-Dimensional', 'Microscopy, Atomic Force', 'Nanostructures', 'Software', 'User-Computer Interface'] | 24,577,105 | [['B03'], ['G06.099.050'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['J01.637.512'], ['L01.224.900'], ['L01.224.900.910']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Axiological-Identitary Collective Action Model (AICAM): A new integrative perspective in the analysis of protest. | Current predictive models of collective action have devoted little attention to personal values, such as morals or ideology. The present research addresses this issue by incorporating a new axiological path in a novel predictive model of collective action, named AICAM. The axiological path is formed by two constructs: ... | ['Civil Disorders', 'Female', 'Humans', 'Male', 'Mass Behavior', 'Models, Psychological', 'Morals', 'Motivation', 'Social Identification', 'Surveys and Questionnaires'] | 31,188,881 | [['I01.880.735.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.813.527'], ['E05.599.695'], ['F01.829.500', 'K01.752.566'], ['F01.658', 'F01.752.543.500.750'], ['F01.145.813.708'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Occurrence and characterization of entomogenic galls in an area of Cerrado sensu stricto and Gallery forest of the state of Bahia, Brazil. | We surveyed insect galls in an area of Cerrado sensu stricto and Gallery forest in the municipality of Caetit? (BA) to contribute to current knowledge of the local flora and its associated gall-inducing insects. Monthly collections were made between February/2015 and January/2016, totaling 12 field campaigns (involving... | ['Animals', 'Brazil', 'Forests', 'Host-Parasite Interactions', 'Insecta', 'Plant Tumors', 'Plants'] | 30,304,224 | [['B01.050'], ['Z01.107.757.176'], ['G16.500.275.157.437', 'N06.230.124.343'], ['G16.527.200.400'], ['B01.050.500.131.617'], ['G15.610.700'], ['B01.650']] | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
For love and money? The impact of family structure on family income. | What do the half-century decline in U.S. marriage and the attendant rise in single parenthood mean for the economic well-being of children, especially children living in single-parent families? Adam Thomas and Isabel Sawhill show how differing living arrangements can be expected to affect families' economic well-being.... | ['Adult', 'Child', 'Family', 'Family Characteristics', 'Female', 'Humans', 'Income', 'Love', 'Male', 'Marriage', 'Poverty', 'United States'] | 16,158,730 | [['M01.060.116'], ['M01.060.406'], ['F01.829.263', 'I01.880.853.150'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['F01.470.734'], ['F01.829.263.315.500.500', 'I01.240.361.500.500', 'I0... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Understanding carers' fall concern and their management of fall risk among older people at home. | BACKGROUND: Many older people (care recipients) experience long-term psychological distress due to the fear of falling again. Falls can affect carers due to concerns about their care recipients falling. Understanding carers' fall concern is crucial to determine if carers are coping with the provision of care or have ad... | ['Accidental Falls', 'Adaptation, Psychological', 'Aged', 'Aged, 80 and over', 'Australia', 'Caregivers', 'Female', 'Humans', 'Independent Living', 'Male', 'Middle Aged', 'Qualitative Research', 'Risk Factors'] | 31,126,237 | [['N06.850.135.122'], ['F01.058'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.639.100', 'Z01.678.100.373'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.050.500', 'N01.224.791.550', 'N06.850.505.400.800.550'], ['M01.060.116.630'], ['H01.770.644.241.850']... | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Pseudo-rearrangement of the MLL gene at chromosome 11q23: a cautionary note on genotype analysis of leukaemia patients. | AIMS: The MLL gene on chromosome 11q23 is frequently disrupted by chromosomal translocations in association with haematological malignancies. Recently, a specific site within the 8.3 kb MLL break-point cluster region that is cleaved during the early stages of apoptosis has been identified. Because MLL gene rearrangemen... | ['Blotting, Southern', 'Bone Marrow', 'Child', 'Chromosomes, Human, Pair 11', 'Cryopreservation', 'Culture Techniques', 'DNA-Binding Proteins', 'Female', 'Gene Rearrangement', 'Histone-Lysine N-Methyltransferase', 'Humans', 'Infant', 'Leukemia', 'Male', 'Myeloid-Lymphoid Leukemia Protein', 'Neoplasm Proteins', 'Precurs... | 9,713,591 | [['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['A15.382.216'], ['M01.060.406'], ['A11.284.187.520.300.325.355', 'G05.360.162.520.300.325.355'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['E05.481.500'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Development of a locally sustainable functional food for people living with HIV in Sub-Saharan Africa: laboratory testing and sensory evaluation. | The use of Lactobacillus rhamnosus GR-1 and micronutrients has been associated with a preserved immune function among people living with HIV. However, use of these products in the developing world remains limited due to the lack of facilities for production. We describe the development of a yogurt with L. rhamnosus GR-... | ['Adolescent', 'Adult', 'Africa South of the Sahara', 'Female', 'Food Handling', 'Functional Food', 'HIV Infections', 'Humans', 'Lactobacillus rhamnosus', 'Male', 'Middle Aged', 'Moringa oleifera', 'Plant Leaves', 'Plant Preparations', 'Probiotics', 'Taste', 'Yogurt', 'Young Adult'] | 21,986,358 | [['M01.060.057'], ['M01.060.116'], ['Z01.058.290'], ['J01.576.423.200'], ['G07.203.300.572', 'J02.500.572'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.353.750.450.475.700', 'B03.510.4... | ['Named Groups [M]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 |
[Fibromatosis of the breast]. | Fibromatosis of the breast is a rare benign mesenchymal transformation of the connective tissue, the origin of which is probably situated in the fascia of the pectoral muscle and the Cooper's ligaments. In the clinical and radiological examination, it is difficult to differentiate between a mammary carcinoma or other m... | ['Adult', 'Biomarkers, Tumor', 'Breast', 'Breast Neoplasms', 'Cell Division', 'Diagnosis, Differential', 'Female', 'Fibroma', 'Humans'] | 1,499,955 | [['M01.060.116'], ['D23.101.140'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E01.171'], ['C04.557.450.565.590.340'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Different stabilities to bile among feline calicivirus strains of respiratory and enteric origin. | Feline calicivirus (FCV) strains isolated from feces (E-FCV) were compared with FCV strains of respiratory origin (R-FCV). All strains were shown to be labile at pH 3.0. All strains except one strain of E-FCV were found to be sensitive to the action of trypsin. When exposed to bile salt (deoxycholic acid sodium salt), ... | ['Animals', 'Antigens, Viral', 'Bile', 'Caliciviridae', 'Cat Diseases', 'Cats', 'Complement Fixation Tests', 'Deoxycholic Acid', 'Diarrhea', 'Feces', 'Neutralization Tests', 'Respiratory System', 'Respiratory Tract Infections'] | 1,626,378 | [['B01.050'], ['D23.050.327'], ['A12.200.087'], ['B04.820.578.298'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E01.370.225.812.735.150', 'E05.200.812.735.150', 'E05.478.594.760.150'], ['D04.210.500.105.225.272', 'D04.210.500.221.430.342'], ['C23.888.821.214'], ['A12.459'], ['E01.370.225.812.735.55... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Short-term repeatability of parameters extracted from radial displacement of muscle belly. | The aim of this study is to analyse the short-term repeatability of the parameters extracted from radial muscle belly response on a stimulation pulse. The method uses a prefixed tension of a displacement sensor tip to the muscle and is being developed for noninvasive and selective evaluation of skeletal muscle contract... | ['Adult', 'Forearm', 'Humans', 'Male', 'Muscle Contraction', 'Muscle Fatigue', 'Muscle, Skeletal', 'Reproducibility of Results'] | 17,379,538 | [['M01.060.116'], ['A01.378.800.585'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494'], ['G11.427.550'], ['A02.633.567', 'A10.690.552.500'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Structure-activity relationship of lipopeptide Group A streptococcus (GAS) vaccine candidates on toll-like receptor 2. | Incorporation of lipoamino acids (LAAs) into peptide structures effectively imparts self-adjuvanting activity onto otherwise ineffective immunogens. Our fully synthetic lipopeptide vaccine candidates against group A streptococcus (GAS) were composed of J14 as a target GAS B-cell epitope alongside a universal helper T-c... | ['Antigens, Bacterial', 'Cell Line', 'Epitopes, B-Lymphocyte', 'Epitopes, T-Lymphocyte', 'Genes, Reporter', 'Humans', 'Lipopeptides', 'Luciferases', 'NF-kappa B', 'Recombinant Proteins', 'Streptococcal Vaccines', 'Streptococcus pyogenes', 'Structure-Activity Relationship', 'Toll-Like Receptor 2'] | 20,045,502 | [['D23.050.161'], ['A11.251.210'], ['D23.050.550.395'], ['D23.050.550.402'], ['G05.360.340.024.340.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.477', 'D12.644.365'], ['D08.811.682.517', 'D12.776.532.510'], ['D05.500.672', 'D12.776.260.600', 'D12.776.660.600', 'D12.776.930.600'], ['D12.776.828'], ['D20.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fetal alcohol exposure and temporal vulnerability: effects of binge-like alcohol exposure on the ventrolateral nucleus of the thalamus. | BACKGROUND: Prenatal alcohol exposure disrupts motor performance in affected offspring. The ventrolateral nucleus (VLN) of the thalamus functions to relay information between the cerebellum and motor cortex. Reductions in the size of the thalamus have been found in children with fetal alcohol syndrome, and therefore a ... | ['Animals', 'Central Nervous System Depressants', 'Ethanol', 'Female', 'Male', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Rats', 'Rats, Sprague-Dawley', 'Ventral Thalamic Nuclei'] | 11,371,727 | [['B01.050'], ['D27.505.696.277', 'D27.505.954.427.210'], ['D02.033.375'], ['G08.686.784.769'], ['C13.703.824.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['A08.186.211.200.317.826.701.900']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dilated intercellular space in the larynx and esophagus of a rabbit reflux model. | OBJECTIVE: In this study, we investigated histological and electron microscopic changes of the laryngeal and esophageal epithelium in an animal model of reflux to demonstrate: (1) the association between laryngopharyngeal reflux (LPR) and gastroesophageal reflux disease (GERD) and (2) the value of dilated intercellular... | ['Animals', 'Case-Control Studies', 'Dilatation, Pathologic', 'Disease Models, Animal', 'Esophagus', 'Extracellular Space', 'Gastroesophageal Reflux', 'Laryngeal Mucosa', 'Laryngopharyngeal Reflux', 'Larynx', 'Microscopy, Electron, Transmission', 'Mucous Membrane', 'Rabbits'] | 23,238,174 | [['B01.050'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.300.325'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A03.556.875.500'], ['A10.082.500', 'A11.284.295'], ['C06.405.117.119.500.484'], ['A04.329.597', 'A04.760.520', 'A10.615.550.760.520'], ['C06.405.117.119.500.484.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan. | Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard and a laboratory strain. The predominant QTL mapped to the rDNA, w... | ['Aging', 'Caloric Restriction', 'DNA Replication', 'DNA, Ribosomal', 'DNA-Binding Proteins', 'Gene Expression Regulation, Fungal', 'Longevity', 'Polymorphism, Genetic', 'Quantitative Trait Loci', 'Replication Origin', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Sirtuin 2'] | 23,505,383 | [['G07.345.124'], ['E02.642.249.200', 'G07.203.650.240.340.150'], ['G02.111.225', 'G05.226'], ['D13.444.308.475'], ['D12.776.260'], ['G05.308.330'], ['G07.345.124.519', 'G07.540'], ['G05.365.795'], ['G05.360.340.024.380.937'], ['G05.360.340.024.220.760', 'G05.360.340.024.745.725'], ['B01.300.107.795.785.800', 'B01.300.... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transcatheter embolization for treatment of diverticular hemorrhage. | Two patients underwent transcatheter embolization for control of massive diverticular hemorrhage after vasopressin infusion had failed to control the bleeding. The role of angiography in the management of diverticular bleeding is discussed. If surgery is being considered, angiography should be utilized to localize the ... | ['Aged', 'Catheterization', 'Diverticulum, Colon', 'Embolization, Therapeutic', 'Gastrointestinal Hemorrhage', 'Humans', 'Male', 'Mesenteric Arteries', 'Middle Aged', 'Radiography'] | 300,168 | [['M01.060.116.100'], ['E02.148', 'E05.157'], ['C06.405.205.282.750.500', 'C23.300.415.500'], ['E02.520.360', 'E02.926.500'], ['C06.405.227', 'C23.550.414.788'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.114.565'], ['M01.060.116.630'], ['E01.370.350.700']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Securing the future of drug discovery for central nervous system disorders. | Innovative partnerships among researchers, patients, regulators, payors and industry are needed to reinvigorate drug discovery for central nervous system disorders. Here, we summarize plans of the Collegium Internationale Neuro-Psychopharmacologicum (CINP) to achieve this goal. | ['Animals', 'British Columbia', 'Central Nervous System Agents', 'Central Nervous System Diseases', 'Drug Discovery', 'Forecasting', 'Humans'] | 25,435,203 | [['B01.050'], ['Z01.107.567.176.160'], ['D27.505.954.427'], ['C10.228'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['I01.320'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 |
Functional characterization of the 5'-regulatory region of the human thrombomodulin gene. | Thrombomodulin, a glycoprotein expressed in endothelial cells, has an important role in the blood coagulation system as a modulator. Functional characterization of the 5'-regulatory region of the human thrombomodulin gene was carried out to identify elements necessary for its expression. We used a series of dissected g... | ['Base Sequence', 'Cells, Cultured', 'Chloramphenicol O-Acetyltransferase', 'Endothelium, Vascular', 'Gene Expression Regulation', 'Humans', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Plasmids', 'Promoter Regions, Genetic', 'Receptors, Cell Surface', 'Receptors, Thrombin', 'Regulatory Sequences, Nucleic ... | 8,393,436 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251'], ['D08.811.913.050.134.170'], ['A07.015.700.500', 'A10.272.491.355'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['E05.393.420.601.575'], ['G05.360.600'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study. | BACKGROUND: Liangshan Yi Autonomous Prefecture is one of the areas that most severely affected by human immunodeficiency virus (HIV) in China, and virological failure on antiretroviral therapy (ART) is serious in this area. Analyses of prevalence and determinants of ART failure, the genetic diversity and drug resistanc... | ['Acquired Immunodeficiency Syndrome', 'Adolescent', 'Adult', 'Anti-HIV Agents', 'China', 'Drug Resistance, Viral', 'Female', 'Genes, pol', 'Genetic Variation', 'HIV-1', 'Humans', 'Infectious Disease Transmission, Vertical', 'Male', 'Minority Groups', 'Mutation', 'Prevalence', 'Reverse Transcriptase Inhibitors', 'Treat... | 32,576,136 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.057'], ['M01.060.116'], ['D27.505.954.122.388.077.088'], ['Z01.252.474.164'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['G05... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Profiling and analysis of multiple constituents in Baizhu Shaoyao San before and after processing by stir-frying using UHPLC/Q-TOF-MS/MS coupled with multivariate statistical analysis. | Baizhu Shaoyao San (BSS) is a famous traditional Chinese medicinal formula widely used for the treatment of painful diarrhea, intestinal inflammation, and diarrhea-predominant irritable bowel syndrome. According to clinical medication, three medicinal herbs (Atractylodis Macrocephalae Rhizoma, Paeoniae Radix Alba, and ... | ['Benzopyrans', 'Chromatography, High Pressure Liquid', 'Cooking', 'Drugs, Chinese Herbal', 'Flavonoids', 'Glycosides', 'Lactones', 'Multivariate Analysis', 'Tandem Mass Spectrometry', 'Terpenes'] | 29,529,536 | [['D03.383.663.283', 'D03.633.100.150'], ['E05.196.181.400.300'], ['J01.576.423.200.200'], ['D20.215.784.500.350', 'D26.335'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['D09.408'], ['D02.540'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['E05.196.566.880'], ['D02.455.8... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Imaging for suspected appendicitis: negative appendectomy and perforation rates. | PURPOSE: To determine which patients suspected of having acute appendicitis benefit from preoperative imaging.MATERIALS AND METHODS: The medical records of 462 consecutive patients who underwent appendectomy for clinically suspected acute appendicitis and underwent preoperative evaluation at our institution were retros... | ['Acute Disease', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Appendectomy', 'Appendicitis', 'Child', 'Child, Preschool', 'Contrast Media', 'False Negative Reactions', 'False Positive Reactions', 'Female', 'Humans', 'Intestinal Perforation', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Retrospective St... | 12,354,996 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.210.078'], ['C01.463.099', 'C06.405.205.099', 'C06.405.469.110.207'], ['M01.060.406'], ['M01.060.406.448'], ['D27.505.259.500', 'D27.720.259'], ['E01.354.340'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Variability in expression of Bothrops insularis snake venom proteases: an ontogenetic approach. | Bothrops insularis is a threatened snake endemic to Queimada Grande Island, southern coast of S?o Paulo, Brazil, and the occurrence of sexual abnormalities in males, females and intersexes (females with functional ovaries and rudimentary hemipenis) has been reported in this population. The aim of this study was to iden... | ['Age Factors', 'Animals', 'Bothrops', 'Crotalid Venoms', 'Factor X', 'Female', 'Male', 'Metalloproteases', 'Peptide Hydrolases'] | 17,398,162 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['B01.050.150.900.833.672.125.937.240.375'], ['D20.888.850.960.200', 'D23.946.833.850.960.200'], ['D08.622.471', 'D12.776.124.125.400', 'D12.776.811.243.471', 'D23.119.400'], ['D08.811.277.656.675'], ['D08.811.277.656']] | ['Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Long-term effects of enteral feeding on growth and mental health in adolescents with anorexia nervosa--results of a retrospective German cohort study. | BACKGROUND/OBJECTIVE: Anorexia nervosa (AN) is a severe eating disorder with a high mortality rate. Treatment regimes show regional and global variation and are sometimes supported by enteral feeding (EF) via nasogastric tube, although risks and benefits are still unclear. We aimed to find out whether EF improves growt... | ['Adolescent', 'Anorexia Nervosa', 'Body Mass Index', 'Cohort Studies', 'Comorbidity', 'Enteral Nutrition', 'Female', 'Germany', 'Hospitalization', 'Humans', 'Intubation, Gastrointestinal', 'Mental Disorders', 'Mental Health', 'Retrospective Studies', 'Risk Factors', 'Surveys and Questionnaires', 'Treatment Outcome', '... | 24,300,908 | [['M01.060.057'], ['F03.400.125'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N05.715.350.225', 'N06.850.490.687'], ['E02.421.360', 'E02.642.500.360'], ['Z01.542.315'], ['E02.760.400', 'N0... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[First-line exploration: fiberoptic gastroscopy or barium meal? A pragmatic evaluation (author's transl)]. | The influence of the initial upper GI tract exploration upon the accuracy and cost of diagnosis was evaluated in 103 in- and out-patients of a hepato-gastroenterology unit. The patients were divided at random into two groups of comparable number, age, sex and clinical findings. One group was first examined by fiberopti... | ['Adult', 'Aged', 'Duodenum', 'Endoscopy', 'Esophageal Diseases', 'Esophagus', 'Female', 'Fiber Optic Technology', 'Gastrointestinal Diseases', 'Humans', 'Male', 'Middle Aged', 'Radiography', 'Stomach', 'Time Factors'] | 7,312,606 | [['M01.060.116'], ['M01.060.116.100'], ['A03.556.124.684.124', 'A03.556.875.249'], ['E01.370.388.250', 'E04.502.250'], ['C06.405.117'], ['A03.556.875.500'], ['H01.671.617.249'], ['C06.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.700'], ['A03.556.875.875'], ['G01.910.857']] | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Mathematical modelling of thermal process to aquatic environment with different hydrometeorological conditions. | This paper presents the mathematical model of the thermal process from thermal power plant to aquatic environment of the reservoir-cooler, which is located in the Pavlodar region, 17 Km to the north-east of Ekibastuz town. The thermal process in reservoir-cooler with different hydrometeorological conditions is consider... | ['Computer Simulation', 'Hydrobiology', 'Models, Theoretical', 'Power Plants'] | 24,991,644 | [['L01.224.160'], ['H01.158.273.248.750', 'H01.277.249.750'], ['E05.599'], ['J01.780', 'J03.540.680']] | ['Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. | CONTEXT: Vitamin D receptors are present in many tissues. Hypovitaminosis D is considered to be a risk factor for atherosclerosis.OBJECTIVE: This study explores the effects of vitamin D replacement on insulin sensitivity, endothelial function, inflammation, oxidative stress, and leptin in vitamin D-deficient subjects.D... | ['Adult', 'Atherosclerosis', 'Biomarkers', 'Blood Flow Velocity', 'Blood Pressure', 'Brachial Artery', 'Endothelium, Vascular', 'Female', 'Humans', 'Insulin Resistance', 'Leptin', 'Linear Models', 'Lipid Peroxidation', 'Male', 'Oxidative Stress', 'Risk Factors', 'Treatment Outcome', 'Vitamin D', 'Vitamin D Deficiency',... | 19,584,181 | [['M01.060.116'], ['C14.907.137.126.307'], ['D23.101'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A07.015.114.139'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['D06.472.699.042.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enhanced cell-surface stability of rescued DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones. | Misfolded proteins destined for the cell surface are recognized and degraded by the ERAD [ER (endoplasmic reticulum) associated degradation] pathway. TS (temperature-sensitive) mutants at the permissive temperature escape ERAD and reach the cell surface. In this present paper, we examined a TS mutant of the CFTR [CF (c... | ['Animals', 'Blotting, Western', 'Cricetinae', 'Cystic Fibrosis Transmembrane Conductance Regulator', 'Endocytosis', 'Half-Life', 'HeLa Cells', 'Humans', 'Immunoprecipitation', 'Temperature'] | 18,052,931 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.992.635.075.250'], ['D12.776.157.530.100.304.500', 'D12.776.157.530.400.175.125', 'D12.776.157.530.450.074.500.500.500.500', 'D12.776.543.550.450.175.125', 'D12.776.543.585.100.30... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cytological diagnostic features of late breast implant seromas: From reactive to anaplastic large cell lymphoma. | Late breast implant seroma may be the presentation of a breast implant-associated anaplastic large cell lymphoma (BI-ALCL), which claims for a prompt recognition. However, BI-ALCL diagnosis on fine-needle aspiration (FNA) might be challenging for pathologists lacking experience with peri-implant breast effusions. Sixty... | ['Adult', 'Aged', 'Antigens, CD', 'Antigens, Differentiation, Myelomonocytic', 'Breast Implantation', 'Breast Neoplasms', 'CD3 Complex', 'Female', 'Gene Rearrangement', 'Humans', 'Ki-1 Antigen', 'Klebsiella oxytoca', 'Lymphocytes', 'Lymphoma, Large-Cell, Anaplastic', 'Macrophages', 'Middle Aged', 'Neutrophils', 'Pseudo... | 28,715,445 | [['M01.060.116'], ['M01.060.116.100'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.900', 'D23.101.100.900'], ['E02.218.565.210', 'E04.650.210', 'E04.680.500.210'], ['C04.588.180', 'C17.800.090.500'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['G05.344'], ['B01.050.150.900.649.313.988.400.112... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Static state hemodynamic variables estimation model for the moving-actuator type total artificial heart. Part. I--cardiac output estimation. | Cardiac output estimation is a very important study for the artificial heart. In this paper, we developed a cardiac output estimation model for the moving-actuator type total artificial heart (MA-TAH) that was developed at Seoul National University Hospital. The proposed model is simple and provides beat-by-beat mean c... | ['Cardiac Output', 'Heart, Artificial', 'Models, Cardiovascular', 'Models, Theoretical', 'Prosthesis Design'] | 10,098,581 | [['E01.370.370.380.150', 'G09.330.380.124'], ['E07.695.300', 'E07.858.082.374'], ['E05.599.395.161'], ['E05.599'], ['E05.320.550', 'E07.695.680']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genetic factors influencing the risk of multiple myeloma bone disease. | A major complication of multiple myeloma (MM) is the development of osteolytic lesions, fractures and bone pain. To identify genetic variants influencing the development of MM bone disease (MBD), we analyzed MM patients of European ancestry (totaling 3774), which had been radiologically surveyed for MBD. Each patient h... | ['Aged', 'Biomarkers, Tumor', 'Bone Diseases', 'Female', 'Genotype', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Neoplasm Staging', 'Osteoprotegerin', 'Polymorphism, Single Nucleotide', 'Prognosis', 'Risk Factors'] | 26,669,972 | [['M01.060.116.100'], ['D23.101.140'], ['C05.116'], ['G05.380'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.595.500', 'C14.907.454.460', 'C15.378.147.780.650', 'C15.378.463.515.460', 'C20.683.515.845', 'C20.683.780.650'], ['E01.789.625'], ['D12.776.543.750.705.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Phylogeography of Ascaris lumbricoides and A. suum from China. | In order to obtain further understanding of genetic structure and evolutionary relationship of Ascaris from humans and pigs, phylogeography study on 12 populations from six endemic regions in China was conducted using mitochondrial DNA markers (cytochrome c oxidase subunit 1 (COX1) and NAD1) and the software programs o... | ['Animals', 'Ascariasis', 'Ascaris lumbricoides', 'Ascaris suum', 'China', 'Cluster Analysis', 'DNA, Helminth', 'Electron Transport Complex I', 'Electron Transport Complex IV', 'Female', 'Genetic Variation', 'Humans', 'Male', 'Molecular Sequence Data', 'Phylogeography', 'Sequence Analysis, DNA', 'Swine', 'Swine Disease... | 21,301,872 | [['B01.050'], ['C01.610.335.508.700.100.070'], ['B01.050.500.500.294.400.500.100.108.425'], ['B01.050.500.500.294.400.500.100.108.700'], ['Z01.252.474.164'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['D13.444.308.315'], ['D05.500.562.249', 'D08.811.600.250.500.500', 'D08.811.682.608.504', 'D12... | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Multiple perineuriomatous melanocytic nevi. | Perineuriomatous differentiation in solitary cutaneous melanocytic nevi has been described. We present an unusual case of a patient with multiple such perineuriomatous nevi. This presentation raises the possibility that a germline mutation may be responsible for the pathogenesis of these unusual lesions. | ['Humans', 'Male', 'Middle Aged', 'Nerve Sheath Neoplasms', 'Nevus, Pigmented', 'Skin Neoplasms'] | 29,468,709 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.580.600', 'C10.551.775.500', 'C10.668.829.725.500'], ['C04.557.665.560.615'], ['C04.588.805', 'C17.800.882']] | ['Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
On-line comprehensive two-dimensional separations of charged compounds using reversed-phase high performance liquid chromatography and hydrophilic interaction chromatography. Part I: orthogonality and practical peak capacity considerations. | Comprehensive on-line two-dimensional liquid chromatography is expected to generate impressive peak capacities, which makes it a method of choice for the analysis of complex samples such as pharmaceutical or biological ones. A comparative study of different sets of chromatographic conditions including stationary phase,... | ['Chromatography, High Pressure Liquid', 'Chromatography, Reverse-Phase', 'Hydrophobic and Hydrophilic Interactions', 'Models, Chemical', 'Peptides', 'Pharmaceutical Preparations'] | 23,022,239 | [['E05.196.181.400.300'], ['E05.196.181.400.495'], ['G02.409'], ['E05.599.495'], ['D12.644'], ['D26']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. | HIF (hypoxia-inducible factor) is the main transcription factor activated by low oxygen tensions. HIF-1alpha (and other alpha subunits) is tightly controlled mostly at the protein level, through the concerted action of a class of enzymes called PHDs (prolyl hydroxylases) 1, 2 and 3. Most of the knowledge of HIF derives... | ['Cell Line, Tumor', 'Cells, Cultured', 'Humans', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'NF-kappa B', 'RNA, Messenger', 'RNA, Small Interfering', 'Signal Transduction'] | 18,393,939 | [['A11.251.210.190', 'A11.251.860.180'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.260.103.625.750', 'D12.776.930.125.625.750'], ['D05.500.672', 'D12.776.260.600', 'D12.776.660.600', 'D12.776.930.600'], ['D13.444.735.544'], ['D13.150.650.700', 'D13.444.735.150.700', 'D13.444.735.790.552.87... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preparation of a hospital rehabilitation system for war and other disasters. | A large number of casualties caused by war are in need of medical rehabilitation. Rehabilitation facilities are unable to cope adequately with them without advance planning and preparedness. Guidelines are suggested for the planning and preparation of a hospital rehabilitation system for war, including the formulation ... | ['Disaster Planning', 'Disasters', 'Hospitals', 'Humans', 'Rehabilitation', 'United Kingdom', 'Warfare'] | 2,215,360 | [['N06.230.100.035'], ['N06.230.100'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.169.063.500', 'E02.831', 'H02.403.680.600', 'N02.421.784'], ['Z01.542.363'], ['I01.880.735.950.500']] | ['Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
A retrospective evaluation of vitamin K1 therapy to reverse the anticoagulant effect of warfarin. | STUDY OBJECTIVE: To assess compliance with the 2001 consensus guidelines of the American College of Chest Physicians (ACCP) regarding administration of vitamin K1 to reverse the anticoagulant effect of warfarin.DESIGN: Retrospective chart review.SETTING: University teaching hospital.PATIENTS: Fifty-five adult inpatient... | ['Anticoagulants', 'Antifibrinolytic Agents', 'Dose-Response Relationship, Drug', 'Drug Administration Routes', 'Drug Antagonism', 'Drug Utilization Review', 'Female', 'Hemorrhage', 'Humans', 'International Normalized Ratio', 'Male', 'Middle Aged', 'Retrospective Studies', 'Vitamin K 1', 'Warfarin'] | 14,594,342 | [['D27.505.954.502.119'], ['D27.505.519.421.500', 'D27.505.954.502.270.463.091'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.267'], ['G07.690.773.968.310'], ['N04.452.706.477.400', 'N04.761.879.300', 'N05.700.900.300'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.625.115.320',... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evaluation of temporomandibular joint noise in partially edentulous patients. | In order to evaluate the presence of TMD (temporomandibular disorder), dissatisfaction related to the use of removable partial dentures (RPD) and the effect of the treatment on temporomandibular joint noises, 13 female patients with Kennedy class I and II mandibular arch were selected. Another 13 young, asymptomatic, d... | ['Adult', 'Aged', 'Case-Control Studies', 'Dental Occlusion, Traumatic', 'Denture, Partial, Removable', 'Diagnosis, Computer-Assisted', 'Female', 'Humans', 'Jaw, Edentulous, Partially', 'Mandible', 'Middle Aged', 'Patient Satisfaction', 'Sound', 'Temporomandibular Joint Disorders', 'Vibration', 'Young Adult'] | 18,841,742 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C07.793.494.293'], ['E06.780.346.760.943.413', 'E07.695.190.200.220.230'], ['E01.158', 'L01.313.500.750.100.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.500.480.450', 'C07.320.550.450... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A network model to predict the risk of death in sickle cell disease. | Modeling the complexity of sickle cell disease pathophysiology and severity is difficult. Using data from 3380 patients accounting for all common genotypes of sickle cell disease, Bayesian network modeling of 25 clinical events and laboratory tests was used to estimate sickle cell disease severity, which was represente... | ['Adolescent', 'Adult', 'Anemia, Sickle Cell', 'Blood Platelets', 'Child', 'Child, Preschool', 'Humans', 'Leukocyte Count', 'Leukocytes', 'Models, Biological', 'Platelet Count', 'Risk Factors'] | 17,600,133 | [['M01.060.057'], ['M01.060.116'], ['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['A11.118.188', 'A15.145.229.188'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Utility of hepatic phosphorus-31 magnetic resonance spectroscopy in a rat model of acute liver failure. | The ability to document the extent of hepatic injury and predict the outcome of fulminant hepatic failure would be helpful in identifying those patients who might benefit from liver transplantation. The aim of the present study was to determine whether in vivo phosphorus-31 magnetic resonance spectroscopy (31P MRS) acc... | ['Animals', 'Humans', 'Liver', 'Liver Failure, Acute', 'Magnetic Resonance Spectroscopy', 'Male', 'Phosphorus', 'Prognosis', 'Rats', 'Rats, Sprague-Dawley'] | 12,580,320 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['C06.552.308.500.750'], ['E05.196.867.519'], ['D01.268.666'], ['E01.789'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Optimising palliative and end of life care in hospital. | The acute hospital setting is increasingly regarded as an important area for the delivery of palliative care. A significant number of patients with advanced, life-limiting illness have a range of palliative care needs, some of which can be met by ward staff, but others may require additional, specialist input. Several ... | ['Education, Nursing, Continuing', 'Hospitals', 'Humans', 'Palliative Care', 'Referral and Consultation', 'Terminal Care', 'United Kingdom'] | 22,848,956 | [['I02.358.212.450', 'I02.358.462.399'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.666', 'N02.421.585.666'], ['N04.452.758.849'], ['E02.760.905', 'N02.421.585.905'], ['Z01.542.363']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
[Morphology of pulmonary complications in AIDS--a study of 208 biopsy and 231 autopsy cases]. | In AIDS patients infectious pulmonary complications may very frequently be demonstrated by both biopsy and autopsy. Bacterial pneumonias occur much more frequently than classic opportunistic infections, e.g. P. carinii pneumonia. Usually, several complications are present concomitantly which impairs diagnosis as well a... | ['Acquired Immunodeficiency Syndrome', 'Autopsy', 'Bacterial Infections', 'Biopsy', 'Humans', 'Lung', 'Lung Diseases', 'Lung Neoplasms', 'Lymphoma', 'Mycoses', 'Opportunistic Infections', 'Retrospective Studies', 'Sarcoma, Kaposi'] | 1,724,820 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['C01.150.252'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E0... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Label-Free, Multiplexed, Single-Molecule Analysis of Protein-DNA Complexes with Nanopores. | Protein interactions with specific DNA sequences are crucial in the control of gene expression and the regulation of replication. Single-molecule methods offer excellent capabilities to unravel the mechanism and kinetics of these interactions. Here, we develop a nanopore approach where a target DNA sequence is containe... | ['Animals', 'Biosensing Techniques', 'DNA', 'DNA, Single-Stranded', 'Drug Evaluation, Preclinical', 'Escherichia coli', 'Escherichia coli Proteins', 'Models, Molecular', 'Nanopores', 'Nanotechnology', 'Nucleic Acid Conformation', 'Protein Binding', 'Rabbits', 'Transcription Factors'] | 28,530,800 | [['B01.050'], ['E05.601.043'], ['D13.444.308'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['E05.290.750', 'E05.337.550'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['E05.599.595'], ['J01.637.512.650'], ['H01.603', 'J01.897.520.600'], ['G02.111.570.820.486', 'G... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Organization of the cerebellum in the pigeon (Columba livia): II. Projections of the cerebellar nuclei. | The projections of the deep cerebellar nuclei in the pigeon have been delineated using autoradiographic and histochemical (WGA-HRP) tracing techniques. A medial (CbM) and lateral (CbL) cerebellar nucleus are recognized and CbM may be further partitioned into internal, intermediate, and intercalate divisions. As in mamm... | ['Animals', 'Axonal Transport', 'Cerebellar Nuclei', 'Cerebellum', 'Columbidae', 'Diencephalon', 'Efferent Pathways', 'Female', 'Horseradish Peroxidase', 'Male', 'Mesencephalon', 'Pons', 'Vestibular Nuclei', 'Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate', 'Wheat Germ Agglutinins'] | 1,711,054 | [['B01.050'], ['G03.143.355.040', 'G04.392.040', 'G11.561.050'], ['A08.186.211.132.810.428.200.337'], ['A08.186.211.132.810.428.200'], ['B01.050.150.900.248.165.150'], ['A08.186.211.200.317'], ['A08.612.380'], ['D08.811.682.732.512'], ['A08.186.211.132.659'], ['A08.186.211.132.810.428.600'], ['A08.186.211.132.810.428.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ocular reticulum cell sarcoma. | Three patients with ocular reticulum cell sarcoma underwent treatment with a combination of chemotherapy and irradiation. All three patients have survived an average of 36 months after treatment, significantly longer than would have been expected with radiation therapy alone. The chemotherapy appears to arrest the prog... | ['Adult', 'Eye Neoplasms', 'Humans', 'Lymphoma, Non-Hodgkin', 'Male', 'Middle Aged'] | 7,013,487 | [['M01.060.116'], ['C04.588.364', 'C11.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480', 'C15.604.515.569.480', 'C20.683.515.761.480'], ['M01.060.116.630']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Stroke volume and left ventricular output in preterm infants with patent ductus arteriosus. | To assess the effect of patent ductus arteriosus (PDA) on left ventricular output (LVO) we studied stroke volume (SV), LVO, and heart rate (HR) in 21 very low birth wt preterm neonates with clinically symptomatic PDA before and after surgical ligation. Six additional infants were also studied before PDA with left-to-ri... | ['Cardiac Output', 'Ductus Arteriosus, Patent', 'Echocardiography, Doppler', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Respiratory Distress Syndrome, Newborn', 'Stroke Volume'] | 2,320,395 | [['E01.370.370.380.150', 'G09.330.380.124'], ['C14.240.400.340', 'C14.280.400.340', 'C16.131.240.400.340'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['C08.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Histological transformation of low malignancy lymphoproliferative syndromes. Clinical and developmental study of 32 cases]. | Fourteen out of 283 patients with chronic lymphoid leukaemia, 2 out of 47 with Waldenstr?m's disease and 16 out of 136 with low malignancy lymphoma (follicular with predominant small cleaved cells, mixed follicular with small and large cells, or diffuse lymphocytic) underwent histological transformation of their diseas... | ['Antineoplastic Combined Chemotherapy Protocols', 'Cell Transformation, Neoplastic', 'Follow-Up Studies', 'Humans', 'Lymphatic Diseases', 'Lymphoma', 'Lymphoproliferative Disorders', 'Retrospective Studies', 'Time Factors'] | 3,160,019 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.697.098.500', 'C23.550.727.098.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.604'], ['C04.557.386', 'C15.604.515.569', 'C20.683.515.761'], ['C15.60... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The continuum of care protocol: a strategic response to Joint Commission change. | Changing mandates of the Joint Commission on Accreditation of Healthcare Organizations, including the 11 functional standards, the nine dimensions of performance, and the interdisciplinary approach, are reviewed. One hospital, City Hospital, strategically managed this change by marrying the principles of strategic mana... | ['Clinical Protocols', 'Continuity of Patient Care', 'Joint Commission on Accreditation of Healthcare Organizations', 'Patient-Centered Care', 'Total Quality Management', 'United States'] | 10,154,923 | [['E02.183', 'N05.715.360.330.125'], ['E02.760.169', 'N02.421.585.169', 'N04.590.233.727.210'], ['N03.706.110.070.410', 'N05.700.200.100.420'], ['N04.590.233.727.407'], ['N04.452.955', 'N04.761.700.675', 'N05.700.792'], ['Z01.107.567.875']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Discrimination of natural scenes in central and peripheral vision. | We conducted suprathreshold discrimination experiments to compare how natural-scene information is processed in central and peripheral vision (16° eccentricity). Observers' ratings of the perceived magnitude of changes in naturalistic scenes were lower for peripheral than for foveal viewing, and peripheral orientation ... | ['Color Perception', 'Contrast Sensitivity', 'Discrimination, Psychological', 'Fixation, Ocular', 'Humans', 'Orientation', 'Sensory Thresholds', 'Space Perception', 'Vision, Ocular', 'Visual Fields', 'Visual Perception'] | 21,640,747 | [['F02.463.593.932.217'], ['E01.370.380.850.950.500', 'F02.463.593.778.435.110', 'F02.463.593.932.281', 'F02.463.593.932.901.500', 'G14.940.500'], ['F02.463.593.257'], ['G14.350.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.058.577', 'F02.830.606'], ['F02.463.593.710'], ['F02.463.593.778'], ['F02.830.81... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. | Caspases mediate essential key proteolytic events in inflammatory cascades and the apoptotic cell death pathway. Human caspases functionally segregate into two distinct subfamilies: those involved in cytokine maturation (caspase-1, -4 and -5) and those involved in cellular apoptosis (caspase-2, -3, -6, -7, -8, -9 and -... | ['Africa', 'African Americans', 'Alzheimer Disease', 'Animals', 'Apoptosis', 'Base Sequence', 'Case-Control Studies', 'Caspase 12', 'Caspases', 'Concanavalin A', 'Cytokines', 'Endoplasmic Reticulum', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Inflammation', 'Lipopolysaccharides', 'NF-... | 15,129,283 | [['Z01.058'], ['M01.686.508.100.100', 'M01.686.754.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['B01.050'], ['G04.146.954.035'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D08.811.277.656.262.500.1... | ['Geographicals [Z]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Nonsustained reentry following successive stimulation of cardiac tissue through a unipolar electrode. | INTRODUCTION: Using numerical simulations, we predict that nonsustained reentry occurs following a strong, premature stimulus through a unipolar electrode.METHODS AND RESULTS: Our simulations were based on the bidomain model of cardiac tissue, and the active membrane properties were represented by the Beeler-Reuter mod... | ['Computer Simulation', 'Electric Conductivity', 'Electric Stimulation', 'Electrodes', 'Evoked Potentials', 'Heart', 'Humans', 'Membrane Potentials', 'Models, Cardiovascular'] | 9,255,684 | [['L01.224.160'], ['G01.358.500.249.277'], ['E05.723.402'], ['E07.305.250'], ['G07.265.216.500', 'G11.561.200.500'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.599.395.161']] | ['Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Evidence for the asymmetrical binding of p-chloromercuriphenyl sulphonate to the human erythrocyte nucleoside transporter. | Nucleosides cross the human erythrocyte membrane by a facilitated-diffusion process which is selectively inhibited by nanomolar concentrations of nitrobenzylthioinosine (NBMPR). The chemical asymmetry of the transporter was investigated by studying the effects of p-chloromercuriphenyl sulphonate (PCMBS) on uridine tran... | ['4-Chloromercuribenzenesulfonate', 'Biological Transport, Active', 'Blood Proteins', 'Dithiothreitol', 'Erythrocyte Membrane', 'Guanosine', 'Humans', 'Membrane Proteins', 'Nucleoside Transport Proteins', 'Phenylmercury Compounds', 'Structure-Activity Relationship', 'Thioinosine', 'Thionucleosides', 'Uridine'] | 2,994,728 | [['D02.455.426.559.389.097.150', 'D02.691.750.740.220', 'D02.886.645.600.080.050.100.100'], ['G03.143.310'], ['D12.776.124'], ['D02.033.800.196', 'D02.886.740.224', 'D09.853.196'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['D03.633.100.759.590.454', 'D13.570.583.454', 'D13.570.800.453'], ['B01.050... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Category Cued Recall test in very mild Alzheimer's disease: discriminative validity and correlation with semantic memory functions. | Episodic memory tests that measure cued recall may be particularly effective in the diagnosis of early Alzheimer's disease (AD) because they examine both episodic and semantic memory functions. The Category Cued Recall (CCR) test provides superordinate semantic cues at encoding and retrieval, and high discriminative va... | ['Aged', 'Alzheimer Disease', 'Cues', 'Discrimination, Psychological', 'Female', 'Humans', 'Male', 'Memory', 'Mental Recall', 'Neuropsychological Tests', 'Predictive Value of Tests', 'Semantics'] | 17,222,122 | [['M01.060.116.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['F02.463.425.234'], ['F02.463.593.257'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540'], ['F02.463.425.540.641'], ['F04.711.513'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Safety of Simultaneous Coronary Artery Bypass Grafting and Carotid Endarterectomy Versus Isolated Coronary Artery Bypass Grafting: A Randomized Clinical Trial. | BACKGROUND AND PURPOSE: The optimal operative strategy in patients with severe carotid artery disease undergoing coronary artery bypass grafting (CABG) is unknown. We sought to investigate the safety and efficacy of synchronous combined carotid endarterectomy and CABG as compared with isolated CABG.METHODS: Patients wi... | ['Aged', 'Carotid Stenosis', 'Coronary Artery Bypass', 'Endarterectomy, Carotid', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Patient Safety', 'Treatment Outcome'] | 28,916,664 | [['M01.060.116.100'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['E04.100.814.456.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.40... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hematoporphyrin derivative (Photofrin II) photosensitization of isolated mitochondria: impairment of anion translocation. | Isolated mitochondria have been incubated in the presence of 6 micrograms/ml hematoporphyrin derivative (Photofrin II), and irradiated at lambda = 365 nm. After 2 min irradiation (30 W/m2), a congruent to 50% inhibition of citric cycle intermediates transport is observed with a rather similar photosensitivity for the s... | ['Animals', 'Anions', 'Biological Transport', 'Carboxylic Acids', 'Dihematoporphyrin Ether', 'Hematoporphyrins', 'In Vitro Techniques', 'Intracellular Membranes', 'Mitochondria, Liver', 'Mitochondrial Swelling', 'Permeability', 'Rats'] | 2,948,508 | [['B01.050'], ['D01.248.497.158'], ['G03.143'], ['D02.241'], ['D03.383.129.578.840.500.462.400.200', 'D03.633.400.909.500.462.400.200', 'D04.345.783.500.462.400.200', 'D23.767.727.462.400.200'], ['D03.383.129.578.840.500.462', 'D03.633.400.909.500.462', 'D04.345.783.500.462', 'D23.767.727.462'], ['E05.481'], ['A11.284.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[2 fatal cases of reaction due to the combination of MAO inhibitors and tricyclic antidepressants. Medico-legal aspects]. | The authors describe two patients who died during hyperthermic reaction following the administration of MAO inhibitors and tricyclic antidepressants in therapeutic doses. In both cases, there was a high increase of temperature, rigidity of skeletal muscles and impairment consciousness with some analog with the syndrome... | ['Adult', 'Antidepressive Agents, Tricyclic', 'Drug Synergism', 'Drug Therapy, Combination', 'Female', 'Humans', 'Jurisprudence', 'Middle Aged', 'Monoamine Oxidase Inhibitors'] | 7,170,585 | [['M01.060.116'], ['D27.505.954.427.700.122.055'], ['G07.690.773.968.477'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.583', 'N03.706.535'], ['M01.060.116.630'], ['D27.505.519.389.616']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Active and passive fatigue in simulated driving: discriminating styles of workload regulation and their safety impacts. | Despite the known dangers of driver fatigue, it is a difficult construct to study empirically. Different forms of task-induced fatigue may differ in their effects on driver performance and safety. Desmond and Hancock (2001) defined active and passive fatigue states that reflect different styles of workload regulation. ... | ['Adolescent', 'Adult', 'Automobile Driving', 'Fatigue', 'Female', 'Humans', 'Male', 'Safety', 'Stress, Psychological', 'Time Factors', 'Workload', 'Young Adult'] | 24,041,288 | [['M01.060.057'], ['M01.060.116'], ['I03.125'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.135.060.075'], ['F01.145.126.990', 'F02.830.900'], ['G01.910.857'], ['I03.946.225.500', 'N04.452.677.650.500'], ['M01.060.116.815']] | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization. | During yeast cell polarization localization of the small GTPase, cell division control protein 42 homologue (Cdc42) is clustered to ensure the formation of a single bud. Here we show that the disease-associated flippase ATPase class I type 8b member 1 (ATP8B1) enables Cdc42 clustering during enterocyte polarization. Lo... | ['Adenosine Triphosphatases', 'Animals', 'Cell Line', 'Cell Polarity', 'Enterocytes', 'Humans', 'Membrane Lipids', 'Mice', 'Phospholipid Transfer Proteins', 'Signal Transduction', 'cdc42 GTP-Binding Protein'] | 26,416,959 | [['D08.811.277.040.025'], ['B01.050'], ['A11.251.210'], ['G04.250'], ['A03.556.124.369.290', 'A10.615.550.444.290', 'A11.436.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.570'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.157.674', 'D12.776.543.693'], ['G02.111.820', 'G04.835'], ['D08.811.277... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of porcine p53 and its regulation by porcine Mdm2. | Pigs have been increasingly recognized as a relevant model for studying many human diseases. However, functions and regulations of numerous critical molecules involved in human diseases are not well characterized in pigs, including the prominent tumor suppressor p53, a transcription factor involved in various anti-prol... | ['Animals', 'Cell Line', 'Gene Expression Regulation', 'Genes, p53', 'Humans', 'Mice', 'Proto-Oncogene Proteins c-mdm2', 'Swine'] | 32,334,023 | [['B01.050'], ['A11.251.210'], ['G05.308'], ['G05.360.340.024.340.375.249.385', 'G05.360.340.024.340.415.400.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['D08.811.464.938.750.562', 'D12.776.624.664.700.185', 'D12.776.660.764'], ['B01.050.150.900.649.313.500.880']... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Noninvasive testing of cerebral perfusion reserve prior to coronary artery bypass graft surgery. | Cerebral perfusion reserve testing using fluorine-18-fluoromethane and positron emission tomographic brain scanning to define cerebral blood flow abnormalities was performed in 5 patients being considered for combined coronary and carotid reconstructive surgery. Blood flow testing during normocapnia and following hyper... | ['Brain', 'Carbon Dioxide', 'Carotid Artery Diseases', 'Carotid Artery, External', 'Cerebral Angiography', 'Cerebrovascular Circulation', 'Coronary Artery Bypass', 'Coronary Disease', 'Fluorine Radioisotopes', 'Humans', 'Hydrocarbons, Fluorinated', 'Preoperative Care', 'Tomography, Emission-Computed'] | 3,132,064 | [['A08.186.211'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['C10.228.140.300.200', 'C14.907.253.123'], ['A07.015.114.186.200.210'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750.180', 'E05.629.937.180'], ['G09.330.100.159'], ['E04... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Microbiological quality of raw and processed wild and cultured edible snails. | BACKGROUND: An increasing interest in snail farming in Greece and other European countries has been observed. Despite the fact that edible snails have been involved with problems of Salmonella spp. contamination, there are to our knowledge only limited studies regarding microbiological safety and hygiene of such produc... | ['Animals', 'Animals, Wild', 'Aquaculture', 'Bacterial Load', 'Bacterial Typing Techniques', 'Conus Snail', 'Cooking', 'Enterobacteriaceae', 'Enterococcus', 'Escherichia coli', 'Food Handling', 'Greece', 'Helix, Snails', 'Intestines', 'Mediterranean Islands', 'Microbial Viability', 'Salmonella', 'Shellfish'] | 24,122,749 | [['B01.050'], ['B01.050.050.300'], ['J01.040.168'], ['E01.370.225.875.150.115', 'E01.370.225.875.220.115', 'E05.200.875.150.115', 'E05.200.875.220.115', 'G06.099.100'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['B01.050.500.644.400.275'], ['J01.576.423.200.200'], ['B03.440.450.425', 'B03.660.250.150'], ['B03... | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
CXCR2-modified CAR-T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma. | Unlike hematological malignancies, solid tumors have proved to be less susceptible to chimeric antigen receptor (CAR)-T cell therapy, which is partially caused by reduced accumulation of therapeutic T cells in tumor site. Since efficient trafficking is the precondition and pivotal step for infused CAR-T cells to exhibi... | ['Animals', 'Carcinoma, Hepatocellular', 'Cell Line, Tumor', 'Cell Movement', 'Chemokine CCL2', 'Chemokine CXCL5', 'Cytotoxicity, Immunologic', 'Gene Expression', 'Humans', 'Immunotherapy, Adoptive', 'Interleukin-8', 'Liver Neoplasms', 'Mice', 'Receptors, Chimeric Antigen', 'Receptors, Interleukin-8B', 'T-Lymphocytes, ... | 31,981,231 | [['B01.050'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['D12.644.276.374.200.110.990.600', 'D12.776.467.374.200.110.990.600', 'D23.125.300.110.990.600', 'D23.469.200.110.990.600', 'D23.529.374.200.11... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Case report on premature hair graying treated with Melitane 5% and oral hair supplements. | With chronological aging, hair turns gray. Untimely premature hair graying (PHG) may tremendously influence on cosmesis, self-credibility, and social life of the affected individuals. Consequently, early treatment is required to improve cosmetic appearance. To the best of our knowledge, until today, only one case of PH... | ['Administration, Topical', 'Adolescent', 'Dietary Supplements', 'Female', 'Hair Color', 'Humans', 'Treatment Outcome', 'alpha-MSH'] | 31,831,925 | [['E02.319.267.120'], ['M01.060.057'], ['G07.203.300.456', 'J02.500.456'], ['G13.500', 'G16.690.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['D06.472.699.327.935.179', 'D06.472.699.327.935.531.750.050', 'D06.472.699.631.525.600.179', 'D06.47... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Classifying single-trial EEG during motor imagery by iterative spatio-spectral patterns learning (ISSPL). | In most current motor-imagery-based brain-computer interfaces (BCIs), machine learning is carried out in two consecutive stages: feature extraction and feature classification. Feature extraction has focused on automatic learning of spatial filters, with little or no attention being paid to optimization of parameters fo... | ['Algorithms', 'Artificial Intelligence', 'Brain', 'Brain Mapping', 'Electroencephalography', 'Evoked Potentials, Motor', 'Humans', 'Imagination', 'Movement', 'Pattern Recognition, Automated'] | 18,714,838 | [['G17.035', 'L01.224.050'], ['G17.035.250', 'L01.224.050.375'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500.385', 'G11.561.200.500.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.188.634'], ['G07... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of cadmium on physiological parameters of cereal and millet plants-A comparative study. | Metal load is an abiotic stress that becomes stronger by continual industrial production, wastage, and long-range transport of contaminants. It deteriorates the conditions of agricultural soil that leads to lower growth of cereals as well as decreasing nutritional value of harvested grains. Cadmium (Cd) entry by food c... | ['Biodegradation, Environmental', 'Cadmium', 'Paspalum', 'Soil Pollutants', 'Species Specificity', 'Stress, Physiological', 'Triticum'] | 27,420,113 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['B01.650.940.800.575.912.250.822.744'], ['D27.888.284.756'], ['G16.824'], ['G07.775'], ['B01.650.940.800.575.912.250.822.918']] | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
In vitro studies on interaction of 4-hydroperoxyifosfamide and 2-mercaptoethanesulphonate in malignant gliomas. | Drug interference of ifosfamide and sodium 2-mercaptoethanesulphonate (MESNA) was studied in three malignant glioma cell cultures (HTZ-17, HTZ-209B, and HTZ-243) by a recently developed in vitro method for evaluation of multimodal treatment interactions. Glioma cell cultures were treated in monolayer 96-well tissue-cul... | ['Antineoplastic Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Combined Modality Therapy', 'Drug Interactions', 'Drug Screening Assays, Antitumor', 'Glioma', 'Humans', 'Ifosfamide', 'Mesna', 'Models, Biological', 'Tumor Cells, Cultured'] | 8,408,185 | [['D27.505.954.248'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E02.186'], ['G07.690.773.968'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vivo blood metal ion levels in patients after total shoulder arthroplasty. | BACKGROUND: Products from metal wear have been identified as a potential cause of adverse local tissue reactions and implant failure in total hip arthroplasty. However, the role of metal ion exposure in patients after total shoulder replacement is unclear. The objective of the present study was to determine in vivo blo... | ['Aged', 'Aged, 80 and over', 'Arthroplasty, Replacement, Shoulder', 'Case-Control Studies', 'Chromium', 'Cobalt', 'Cross-Sectional Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Ions', 'Male', 'Middle Aged', 'Prosthesis Design', 'Retrospective Studies', 'Shoulder Prosthesis', 'Titanium'] | 30,518,478 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.110.110.299', 'E04.650.110.299', 'E04.680.101.110.299'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D01.268.556.175', 'D01.268.956.124', 'D01.552.544.175'], ['D01.268.556.185', 'D01.268.956.155', 'D01.552.544.185'], ['E05.318... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Therapeutic effects of Lamivudine in combination with Thymopentin on chronic hepatitis B]. | OBJECTIVE: To explore the efficacy of anti-viral drug in combination with immunoregulatory agent in treatment of chronic hepatitis B.METHODS: Totally 98 patients with chronic hepatitis B were divided at random into 3 groups. In groups A (42 cases) lamivudine was used in combination with thymopentin to treat chronic hep... | ['Adjuvants, Immunologic', 'Adult', 'Antiviral Agents', 'Drug Therapy, Combination', 'Female', 'Hepatitis B virus', 'Hepatitis B, Chronic', 'Humans', 'Lamivudine', 'Male', 'Middle Aged', 'Thymopentin', 'Treatment Outcome'] | 12,665,914 | [['D27.505.696.477.067'], ['M01.060.116'], ['D27.505.954.122.388'], ['E02.319.310'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440.435.100', 'C06.552.380.350.100', 'C06.552.380.705.437.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.742... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Time-Resolved Spectroscopic Study of the Defluorination and Cyclization Reactions of Lomefloxacin in Water. | The mechanism of the defluorination reaction(s) of lomefloxacin (LF) upon light illumination was investigated by using ultrafast laser flash photolysis combined with transient resonance Raman spectroscopy in near neutral water solution. The zwitterionic configuration of LF was determined to be the main species present ... | ['Cyclization', 'Fluoroquinolones', 'Halogenation', 'Lasers', 'Photolysis', 'Spectrum Analysis, Raman', 'Time Factors', 'Water'] | 28,332,403 | [['G02.111.180', 'G02.607.133', 'G03.208'], ['D03.633.100.810.835.322'], ['G02.111.323', 'G03.360'], ['E07.632.490', 'E07.710.520'], ['G02.740.685'], ['E05.196.822.860', 'E05.196.867.890'], ['G01.910.857'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Delivery of perioperative chemotherapy for bladder cancer in routine clinical practice. | BACKGROUND: Few articles have documented regimens and timing of perioperative chemotherapy for bladder cancer in routine practice. Here, we describe practice patterns in the general population of Ontario, Canada.METHODS: In this retrospective cohort study, treatment and physician billing records were linked to the Onta... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Combined Chemotherapy Protocols', 'Canada', 'Carboplatin', 'Chemotherapy, Adjuvant', 'Cisplatin', 'Cohort Studies', 'Cystectomy', 'Deoxycytidine', 'Doxorubicin', 'Female', 'Humans', 'Male', 'Methotrexate', 'Middle Aged', 'Neoadjuvant Therapy', 'Retrospective Studie... | 24,915,872 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['Z01.107.567.176'], ['D02.257.125'], ['E02.186.170', 'E02.319.170'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Monte Carlo calculations applied to the parametrical studies in a whole body counter. | The use of a Monte Carlo code for the analysis and interpretation of whole body counting measurements is described. The sources of error are analysed and commented to show how a counting geometry can be improved by improving accuracy and precision in a measurement. The effects of body size, contamination distribution a... | ['Humans', 'Monte Carlo Method', 'Phantoms, Imaging', 'Scattering, Radiation', 'Whole-Body Counting'] | 17,526,910 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['E07.671'], ['E05.196.822', 'G01.867'], ['E05.799.950']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Rapid detection of trace bacteria in biofluids using porous monoliths in microchannels. | We present advancements in microfluidic technology for rapid detection of as few as 10 rickettsial organisms in complex biological samples. An immuno-reactive filter, macroporous polyacrylamide monolith (PAM), fabricated within a microfluidic channel enhances solid-phase immuno-capture, staining and detection of target... | ['Acrylic Resins', 'Biosensing Techniques', 'Equipment Design', 'Humans', 'Microfluidic Analytical Techniques', 'Porosity', 'Rickettsia typhi', 'Sensitivity and Specificity', 'Typhus, Endemic Flea-Borne'] | 24,316,449 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['E05.601.043'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.588.465'], ['G01.374.710'], ['B03.660.050.783.875.650.650.810'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Brain Connectivity and Cognitive Flexibility in Nonirradiated Adult Survivors of Childhood Leukemia. | Background: This study aimed to assess functional and structural brain connectivity in adult childhood leukemia survivors and the link with cognitive functioning and previously identified risk factors such as intrathecal methotrexate dose and age at start of therapy.Methods: Thirty-one nonirradiated adult childhood leu... | ['Adolescent', 'Adult', 'Age of Onset', 'Brain', 'Cancer Survivors', 'Case-Control Studies', 'Child', 'Cognition', 'Female', 'Humans', 'Injections, Spinal', 'Leukemia', 'Magnetic Resonance Imaging', 'Male', 'Methotrexate', 'Nerve Net', 'Neuronal Plasticity', 'White Matter', 'Young Adult'] | 29,514,304 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['A08.186.211'], ['M01.860.350'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['F02.463.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.580'], ['C04.557.337'],... | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Weekly Taxol (Paclitaxel) administration in the second-line treatment of breast cancer]. | Based on phase II and III trials Taxol administered in the form of three times/week 1 or 3 hr infusion as mono-or combined chemotherapy of breast cancer is an effective treatment option. These studies proved that this form of drug delivery is effective and well tolerated and the overall response rate is around 50%. The... | ['Antineoplastic Agents, Phytogenic', 'Breast Neoplasms', 'Drug Administration Schedule', 'Female', 'Humans', 'Paclitaxel'] | 12,202,898 | [['D27.505.954.248.179'], ['C04.588.180', 'C17.800.090.500'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.426.392.368.242.888.777', 'D02.455.849.291.850.777']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of ovarian membrane receptor for 17,20beta-dihydroxy-4-pregnen-3-one, a maturation-inducing hormone in yellowtail, Seriola quinqueradiata. | In our previous studies, we tentatively identified 17,20 beta-dihydroxy-4-pregnen-3-one (17,20 beta-P) as a maturation-inducing hormone (MIH) in yellowtail (Seriola quinqueradiata) through in vivo and in vitro experiments. In this study, we investigated the binding sites for radioactive 17,20 beta-P and characterized t... | ['Animals', 'Binding Sites', 'Binding, Competitive', 'Cell Membrane', 'Chorionic Gonadotropin', 'Female', 'Hydrogen-Ion Concentration', 'Hydroxyprogesterones', 'Male', 'Oocytes', 'Ovary', 'Perciformes', 'Receptors, Cell Surface', 'Tritium'] | 12,161,204 | [['B01.050'], ['G02.111.570.120'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['A11.284.149'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['G02.300'], ['D04.210.500.745.745.654.829.395', 'D06.472.334.851.687.750.478'], ['A05.360.490.690.680', 'A11.497.497.600']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cystic fibrosis in a child with situs inversus, a distinctively unusual association. | Cystic fibrosis is the most frequently witnessed potentially lethal autosomal recessive, genetic disease but its incidence is extremely low in South-Asian population. We report a case Cystic Fibrosis in a patient with Situs inversus, a condition not witnessed in medical literature of Pakistan or more captivatingly even... | ['Child, Preschool', 'Cystic Fibrosis', 'Humans', 'Male', 'Situs Inversus'] | 20,361,688 | [['M01.060.406.448'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C16.131.810']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Chronic L-NAME hypertension in rats and autoregulation of juxtamedullary preglomerular vessels. | The impact of chronic NG-nitro-L-arginine methyl ester (L-NAME)-induced hypertension (20 mg.kg-1.day-1 po, for 25 days) on pressure responsiveness was assessed in vessels ranging from arcuate arteries (ArcA) to juxtaglomerular afferent arterioles (JAA), using videomicroscopy and blood-perfused juxtamedullary nephron (J... | ['Actins', 'Animals', 'Arginine', 'Blood Pressure', 'Blood Vessels', 'Chronic Disease', 'Hemodynamics', 'Homeostasis', 'Hypertension', 'Juxtaglomerular Apparatus', 'Male', 'Muscle, Smooth, Vascular', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Rats', 'Rats, Wistar', 'Renal Circulation'] | 7,653,592 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A07.015'], ['C23.550.291.500'], ['G09.330.380'], ['G07.410'], ['C14.907.489'], ['A05.810.453.324.359.520', 'A05.810.453.736.520.52... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Outcomes after surgical treatment of missed Monteggia fractures in children. | BACKGROUND: Chronic dislocation of the radial head treatment in Monteggia fracture dislocation is still controversial. We present a large series of patients treated in our Institution.MATERIALS AND METHODS: The outcome of 22 children treated surgically between 1988 and 2011 for post-traumatic chronic radial head disloc... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', "Monteggia's Fracture", 'Radiography', 'Treatment Outcome'] | 25,957,548 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.518.336.750', 'C26.289.336.750', 'C26.404.937.547'], ['E01.370.350.700'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice. | In this study, we used GM2/GD2 synthase knockout (GM2/GD2?/?) mice to examine the influence of deficiency in ganglioside “a-pathway” and “b-pathway” on cognitive performances and hippocampal synaptic plasticity. Eight-week-old GM2/GD2?/? male mice showed a longer escape-latency in Morris water maze test and a shorter l... | ['Animals', 'Avoidance Learning', 'CA1 Region, Hippocampal', 'Calcium', 'Cognition Disorders', 'Electric Stimulation', 'Excitatory Postsynaptic Potentials', 'G(M1) Ganglioside', 'In Vitro Techniques', 'Long-Term Potentiation', 'Male', 'Maze Learning', 'Memory Disorders', 'Mice', 'Mice, Knockout', 'N-Acetylgalactosaminy... | 24,765,676 | [['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['A08.186.211.180.405.099', 'A08.186.211.200.885.287.500.345.099'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['F03.615.250'], ['E05.723.402'], ['G04.580.887.249', 'G07.265.675.887.249', 'G07.265.880.750.199', 'G11.561.570.918.249', 'G11.561.830.750... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of concentration of oesophageal and gastric cardia cancer surgery on long-term population-based survival. | BACKGROUND: The objective was to evaluate the impact of concentration of surgery for oesophageal and gastric cardia cancer on long-term survival in the population-based Eindhoven Cancer Registry area. In contrast to most previous studies, this study aimed to evaluate both surgically and non-surgically treated patients,... | ['Aged', 'Cardia', 'Esophageal Neoplasms', 'Female', 'Humans', 'Male', 'Middle Aged', 'Netherlands', 'Proportional Hazards Models', 'Registries', 'Retrospective Studies', 'Stomach Neoplasms', 'Survival Analysis'] | 21,509,748 | [['M01.060.116.100'], ['A03.556.875.875.163'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.542.651'], ['E05.318.740.500.700', 'E05.318.740.600.700', 'E05.318.740.750.725', 'E05.318.740.99... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Coping with loneliness: evaluation of a group course for elderly widows]. | The present study was designed to evaluate a group course of 11 sessions, aimed at reducing loneliness in elderly widows. Twenty widows participated (mean age: 67 yrs), who were all reasonably or very satisfied with the experience of participation as well as with the format and leadership of the course. At the beginnin... | ['Adaptation, Psychological', 'Aged', 'Depression', 'Female', 'Group Processes', 'Humans', 'Loneliness', 'Middle Aged', 'Program Evaluation', 'Single Person', 'Surveys and Questionnaires'] | 7,809,918 | [['F01.058'], ['M01.060.116.100'], ['F01.145.126.350'], ['F01.829.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.470.713', 'I01.880.853.748.435'], ['M01.060.116.630'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['F01.829.263.315.500.725', 'I01.240.361.500.725', 'I01.880.853.150.423.500.725', 'M01... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with clear cell endometrial cancer. | A 65-year-old Caucasian woman with a known history of clear cell endometrial cancer presented with hypercalcemia. Further evaluation demonstrated that the patient had primary hyperparathyroidism due to a parathyroid adenoma, as well as an increased parathyroid hormone-related peptide secondary to her malignancy. To the... | ['Adenocarcinoma, Clear Cell', 'Adenoma', 'Aged', 'Calcium', 'Disease Progression', 'Endometrial Neoplasms', 'Female', 'Humans', 'Hypercalcemia', 'Hyperparathyroidism, Primary', 'Neoplasms, Multiple Primary', 'Parathyroid Hormone-Related Protein', 'Parathyroid Neoplasms', 'Parathyroidectomy', 'Postoperative Complicatio... | 19,005,452 | [['C04.557.470.200.025.045'], ['C04.557.470.035'], ['M01.060.116.100'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['C23.550.291.656'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.174.451', 'C18.452.950.340'], ... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Assessment of telomere length, phenotype, and DNA content. | Telomere sequences at the end of chromosomes control somatic cell division; therefore, telomere length in a given cell population provides information about its replication potential. This unit describes a method for flow cytometric measurement of telomere length in subpopulations using fluorescence in situ hybridizati... | ['Animals', 'DNA', 'Flow Cytometry', 'Humans', 'In Situ Hybridization, Fluorescence', 'Phenotype', 'Ploidies', 'Resting Phase, Cell Cycle', 'Telomere'] | 18,770,803 | [['B01.050'], ['D13.444.308'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325.350'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of cranberry juice and cranberry proanthocyanidins on the infectivity of human enteric viral surrogates. | The effect of cranberry juice (CJ) and cranberry proanthocyanidins (PAC) on the infectivity of human enteric virus surrogates, murine norovirus (MNV-1), feline calicivirus (FCV-F9), MS2(ssRNA) bacteriophage, and phiX-174(ssDNA) bacteriophage was studied. Viruses at high (approximately 7 log(10) PFU/ml) or low (approxim... | ['Antiviral Agents', 'Bacteriophages', 'Beverages', 'Calicivirus, Feline', 'Consumer Product Safety', 'Dose-Response Relationship, Drug', 'Foodborne Diseases', 'Humans', 'Norovirus', 'Proanthocyanidins', 'Vaccinium macrocarpon', 'Viral Load', 'Virulence'] | 20,417,404 | [['D27.505.954.122.388'], ['B04.123'], ['G07.203.100', 'J02.200'], ['B04.820.578.298.887.150'], ['N06.850.210'], ['G07.690.773.875', 'G07.690.936.500'], ['C25.723.415'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B04.820.578.298.550'], ['D03.383.663.283.266.450.700', 'D03.633.100.150.266.450.700', 'D05.750.078.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options. | Cardio-facio-cutaneous (CFC) syndrome is a sporadic developmental disorder characterized by distinctive craniofacial features, heart defects, mental retardation and ectodermal abnormalities. We recently reported missense germline mutations in the genes MEK1 and MEK2 in patients with CFC. These mutations, including F53S... | ['Animals', 'Binding Sites', 'COS Cells', 'Cell Line', 'Chlorocebus aethiops', 'Craniofacial Abnormalities', 'Germ-Line Mutation', 'Heart Defects, Congenital', 'Humans', 'Imidazoles', 'MAP Kinase Kinase 1', 'MAP Kinase Kinase 2', 'MAP Kinase Signaling System', 'Phosphorylation', 'Protein Kinase Inhibitors', 'Rats', 'Re... | 17,981,815 | [['B01.050'], ['G02.111.570.120'], ['A11.251.210.172.500', 'A11.329.228.220'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['C05.660.207', 'C16.131.621.207'], ['G05.365.590.350'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of the major polypeptides of the erythrocyte nuclear envelope. | The three most abundant nonhistone polypeptides (molecular weights 75,000, 71,000 and 61,000) of the avian erythrocyte nucleus have previously been isolated in the nuclear envelope fraction. They have been separated by sodium dodecylsulfate-polyacrylamide gel electrophoresis and peptide-mapped after limited enzymatic d... | ['Amino Acids', 'Animals', 'Chickens', 'Erythrocytes', 'Membrane Proteins', 'Molecular Weight', 'Nuclear Envelope', 'Nucleoproteins', 'Peptide Fragments', 'Peptides'] | 513,770 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Safety of transtympanic application of probiotics in a chinchilla animal model. | BACKGROUND: Chronic suppurative otitis media can be recalcitrant and difficult to treat, particularly with the increasing occurrence of antibiotic resistance. Lactobacillus plantarum is a probiotic that has been shown to decrease S. aureus and P. aeruginosa growth in wounds, making it a good candidate for the treatment... | ['Administration, Topical', 'Animals', 'Chinchilla', 'Chronic Disease', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Drug Administration Schedule', 'Female', 'Follow-Up Studies', 'Hearing Tests', 'Otitis Media, Suppurative', 'Probiotics', 'Random Allocation', 'Reference Values', 'Risk Assessment', 'Tr... | 29,166,927 | [['E02.319.267.120'], ['B01.050'], ['B01.050.150.900.649.313.992.328'], ['C23.550.291.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.283'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E01.370.382.375'], ['C01.830.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Involvement of the spinal posterior horn in Gerstmann-Str?ussler-Scheinker disease (PrP P102L). | OBJECTIVE: The authors studied the pathomechanisms of the characteristics associated with Gerstmann-Str?ussler-Scheinker disease (GSS).BACKGROUND: GSS, associated with a missense mutation at codon 102 of the prion protein (PrP) gene (GSS102), is a hereditary disorder that presents with progressive ataxia and dementia, ... | ['Adult', 'Codon', 'Female', 'Gerstmann-Straussler-Scheinker Disease', 'Humans', 'Immunohistochemistry', 'Mutation, Missense', 'Prions', 'Spinal Cord'] | 9,932,941 | [['M01.060.116'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['C01.207.800.350', 'C10.228.228.800.350', 'C10.574.500.425', 'C10.574.843.400', 'C16.320.400.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Morton's neuroma: a microscopic evaluation. | Microscopic evaluation of the interdigital neuroma is described in 24 nerves which were evaluated at six cross-section areas for size of the nerve and width of the perineural along with the fascicle diameter and the size and number of blood vessels inside each fascicle. A relationship was noted between the level of the... | ['Female', 'Foot', 'Foot Diseases', 'Humans', 'Male', 'Neuroma', 'Tarsal Joints'] | 6,519,606 | [['A01.378.610.250'], ['C05.360', 'C17.800.321'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.580.600.610'], ['A02.835.583.378.831']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An in vitro approach to potential methadone metabolic-inhibition interactions. | OBJECTIVE: The aim of this study was to assess the drug interaction potential of psychotropic medication on methadone N-demethylation using cDNA-expressed cytochrome P450 CYP enzymes.METHODS: Methadone was incubated with various drugs (n = 10) and cDNA-expressed CYP3A4, CYP2D6, CYP2B6, CYP2C19 and CYP1A2 enzymes to scr... | ['Algorithms', 'Amitriptyline', 'Analgesics, Opioid', 'Atomoxetine Hydrochloride', 'Chromatography, Liquid', 'Citalopram', 'Clozapine', 'Cytochrome P-450 Enzyme Inhibitors', 'Cytochrome P-450 Enzyme System', 'Dose-Response Relationship, Drug', 'Drug Interactions', 'Isoenzymes', 'Kinetics', 'Methadone', 'Methylation', '... | 17,598,095 | [['G17.035', 'L01.224.050'], ['D02.455.426.559.847.181.384.100', 'D04.615.181.384.100'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['D02.092.831.085'], ['E05.196.181.400'], ['D02.092.831.170', 'D02.626.320', 'D03.633.100.127.187'], ['D0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Psychological Factors that Lessen the Impact of COVID-19 on the Self-Employment Intention of Business Administration and Economics' Students from Latin America. | BACKGROUND: The 2019 coronavirus disease epidemic (Covid-19) is a public health emergency of international concern and poses a challenge to the labor market. The pandemic has a devastating and disproportionate effect on young workers, their interest in entrepreneurship, and their mental health. Research is needed to de... | ['Adaptation, Psychological', 'Adolescent', 'Adult', 'Betacoronavirus', 'COVID-19', 'Coronavirus Infections', 'Economics', 'Employment', 'Female', 'Humans', 'Intention', 'Latin America', 'Male', 'Mental Health', 'Pandemics', 'Pneumonia, Viral', 'SARS-CoV-2', 'Students', 'Surveys and Questionnaires', 'Young Adult'] | 32,708,034 | [['F01.058'], ['M01.060.057'], ['M01.060.116'], ['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['C01.925.782.600.550.200'], ['I01.261', 'N03.219'], ['N01.824.245'], ['B01.050.150.900.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Cause od death statistics and death certificate documentation. 1. Historical development of cause of death statistics of fetal death, infants and children and current regulations in the GDR]. | After having described the beginnings of documentation and statistics of causes of death of newborns and children the development of this branch of medical statistics in the GDR and the introduction of a special death certificate in 1961 is dealt with. To help obstetricians, perinatologists and pediatrists to tackle th... | ['Cause of Death', 'Child', 'Child, Preschool', 'Death Certificates', 'Female', 'Fetal Death', 'Germany, East', 'Humans', 'Infant', 'Infant Mortality', 'Infant, Newborn', 'Mortality', 'Pregnancy', 'Vital Statistics'] | 2,796,126 | [['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.308.940.350', 'L01.399.250.900.350', 'N04.452.859.264', 'N05.715.360.300.715.315', 'N06.850.520.308.940.350'], ['C13.703.223', 'C23.550.260.585'], ['Z01.586.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Information Science [L]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Serum thyroxine concentrations following fixed-dose radioactive iodine treatment in hyperthyroid cats: 62 cases (1986-1989). | The medical records of 62 hyperthyroid cats treated with a fixed dose of 4 mCi of radioactive iodine (131I) were reviewed. In 60 cats, serum thyroxine concentrations were determined after treatment, allowing evaluation of treatment success. Eighty-four percent of the cats had normal serum thyroxine concentrations after... | ['Animals', 'Cat Diseases', 'Cats', 'Female', 'Hyperthyroidism', 'Iodine Radioisotopes', 'Male', 'Retrospective Studies', 'Thyroxine'] | 2,211,313 | [['B01.050'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['C19.874.397'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Successful snakebite treatment in three juvenile African wild dogs (Lycaon pictus) with polyvalent antivenom: a Namibian case report. | This article reports the first documented treatment of venomous snakebite with a polyvalent snake antivenom from the South African Institute for Medical Research in endangered African wild dogs (Lycaon pictus). Three juvenile male animals (6.5 months of age) showed clinical signs after being bitten by an unidentified v... | ['Anesthesia, General', 'Animals', 'Antivenins', 'Behavior, Animal', 'Canidae', 'Fluid Therapy', 'Male', 'Namibia', 'Snake Bites', 'Social Behavior'] | 23,718,740 | [['E03.155.197'], ['B01.050'], ['D12.776.124.486.485.114.573.601.138', 'D12.776.124.790.651.114.573.601.138', 'D12.776.377.715.548.114.573.601.138', 'D20.215.401.601.163'], ['F01.145.113'], ['B01.050.150.900.649.313.750.250.216'], ['E02.319.360'], ['Z01.058.290.175.580'], ['C25.723.127.442', 'C26.176.724'], ['F01.145.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
An efficient and reproducible protocol for the production of salt tolerant transgenic wheat plants expressing the Arabidopsis AtNHX1 gene. | We present an efficient method for the production of transgenic salt tolerant hexaploid wheat plants expressing the Arabidopsis AtNHX1 gene. Wheat mature zygotic embryos were isolated from two hexaploid bread wheat (Triticum aestivum) cultivars (namely: Gemmeiza 9 and Gemmeiza 10) and were transformed with the A. tumef... | ['Arabidopsis', 'Arabidopsis Proteins', 'Breeding', 'Cation Transport Proteins', 'Gene Transfer Techniques', 'Genome, Plant', 'Plants, Genetically Modified', 'Salt-Tolerant Plants', 'Sodium-Hydrogen Exchangers', 'Transformation, Genetic', 'Triticum'] | 25,007,249 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['E05.820.150', 'G05.090'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['E05.393.350'], ['G05.360.340.365'], ['B01.650.520', 'B05.620.600'], ['B01.650.723'], ['D12.776.157.530.450.162.775', 'D12.776.157.530.937.703', 'D12.776.543.550.190.775', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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